SIRT1 Gene Targets


Gene/Reference


14-3-3ξ146

Ac-CoA synthase151

AKT149

APE1159

AR135

ATG530

ATG730

ATG830

BCL6186

BMAL138

CBP22

CIITA200

c-JUN65

c-MYC83

Cortactin31

CREB160

DNMT1163

eNOS167

ERRα172

FOXO1176

FOXO3A181

FOXO4187

FOXP3191

FXR195

HIC1201

HIF1α147

HIF2α152

Histone H1155

Histone H34

Histone H44

HMGSC1168

hMOF25

HNF4α177

HSF1182

IRS2117,188

Ku70126,192

LKB1196

LXR202

MeCP2148

MEF2D153

MMP2156

MYST222

NBS1164

NF-κB (p65)169

NHLH2173

NID178

Nrf2183

p30023,181

p5326,27

p73197

PAX3203

PDK1149

PER237

PGAM1157

PGC1α47,161

PGC1β165

PIP5Kγ170

PPARγ174

PTEN179

RARβ184

RB189

RFX5206

SATB1193

SMAD7198

SREBP1c204

STAT3150

SUV39H1154

SV40 Tag158

TAT (HIV)162

Tau166

TIP5 (NCoR)171

TIP6025,175

TORC1180

WRN185

XBP190

XPA194

YAP199

Zyxin205

β-catenin144

Note: Those proteins labeled in bold are normally cytoplasmic, while those that are not in bold are at least partially nuclear.

 

Source: McBurney, M.W., Clark-Knowles, K.V., Caron, A.Z. and Gray, D.A., 2013. SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress. Genes & cancer4(3-4), pp.125-134.