Aging and Senescence

     Geroprotectors
Name Name> of organism Mean LS% Mddian LS% Max LS% Reference
Amoxapine Caenorhabiditis elegans 33     24134630
Amperozide Hydrochloride Caenorhabiditis elegans 38     24134630
Ascorbic Acid Caenorhabiditis elegans 66.67     19580823
Aspirin Caenorhabiditis elegans 23     22866967
Aspirin Mice   8   18631321
Bacitracin Caenorhabiditis elegans     74 22114686
Baicalein Caenorhabiditis elegans 45 57 24 23339711
2-Deoxy-D-Glucose Caenorhabiditis elegans 17   25 17908557
2-Deoxy-D-Glucose Rat     -10  
2-Mercaptoethanol Mice 13.2   12 6334792
2,4-Dinitrophenol Mice 7 7   18505478
3,3-Diethyl-2-Pyrrolidinone Caenorhabiditis elegans 31   49 15653505
3,4-Dichloroisocoumarin Caenorhabiditis elegans 13     24134630
Caffeic Acid Caenorhabiditis elegans 11     21503726
Caffeine Schizosaccharomyces pombe       23551936
Caffeine Saccharomyces cerevisiae       18513215
Caffeine Saccharomyces cerevisiae       24039592
Caffeine Caenorhabditis elegans   29.4 52 22114686
Carbenicillin Caenorhabditis elegans 23.67     23540700
Carbonyl Cyanide M-Chlorophenyl Hydrazone Caenorhabditis elegans   60   19442682
Carbonylcyanide-P-Trifluoromethoxyphenylhydrazone Caenorhabditis elegans 38.46     18221415
Chromium Picolinate Rat     36 Evans GW, Meyers IK (1994) Life span is increased in rats supplemented with chromium -pyridine 2-carboxylate complex. Adv In Sci Res 1, 19-23
Ciclopirox Olamine Caenorhabditis elegans     52 22114686
Cinnarizine Caenorhabditis elegans 15     24134630
Cis-(Z)-Flupenthixol Dihydrochloride Caenorhabditis elegans 30     24134630
Clofibrate Caenorhabditis elegans 16.2     23603800
Cortexolone Maleate Caenorhabditis elegans 11     24134630
Creatine Mice   9   17416441
Baicalein Caenorhabiditis elegans     52 22114686
Beauveriolide I Saccharomyces cerevisiae       22790951
Berberine Drosophila melanogaster 27 57 78 DOI:10.4236/ajps.2012.327123
Beta-Estradiol Caenorhabiditis elegans 7     24134630
Bezafibrate Caenorhabiditis elegans 12.96     23603800
Brl 15572 Caenorhabiditis elegans 10     24134630
Brl 50481 Caenorhabiditis elegans 18     24134630
BTCP Hydrochloride Caenorhabiditis elegans 14     24134630
Buformin Caenorhabiditis elegans   23.5 26.1 Bakaev VV (2002. Effect of 1-butylbiguanide hydrochloride on the longevity in the nematoda Caenorhabditis elegans. Biogerontology 3 (Suppl 1): 23–24
Buformin Rat 7.3   5.5 14618027
Butein Saccharomyces cerevisiae       12939617
Butylated Hydroxytoluene Mice 19   23 448040
CaEDTA Caenorhabiditis elegans   23.39 12.49 25554795
4-Phenyl-3-Furoxancarbonitrile Caenorhabiditis elegans 30     24134630
4-Phenylbutyrate Drosophila melanogaster 36 40 41 11792861
4′-O-Methyl Epicatechin Caenorhabiditis elegans 13 11 10 http://www.sciencedirect.com/science/article/pii/S0963996911005904
7-Cyclopentyl-5-(4-Phenoxy)Phenyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamine Caenorhabiditis elegans 11     24134630
Acarbose Mice   22 11 24245565
Acetaminophen Caenorhabiditis elegans     66 22114686
Amn082 Caenorhabiditis elegans 8     24134630
Carnosine Drosophila melanogaster 20     20681748
Catechin Caenorhabditis elegans 9 13   19501612 21805983
Celecoxib Caenorhabditis elegans 20     21348927
Chicoric Acid Caenorhabditis elegans 20.6     24244361
Chloramphenicol Caenorhabditis elegans   17   23698443
Chlorprothixene Hydrochloride Caenorhabditis elegans 33     24134630
10-Hydroxy-2-Decenoic Acid Caenorhabiditis elegans 11     25789174
1400W Drosophila melanogaster     13 24096697
1400W Drosophila melanogaster 7     24096697
17-A-Estradiol Mice   12 0 24245565
2-(2-Aminophenyl)-1H-Benzimidazole Caenorhabiditis elegans   35   21451522
2-(2-Hydroxyphenyl) Benzothiazole (Hbt) Caenorhabiditis elegans   23   21451522
2-(2-Hydroxyphenyl)-Benzoxazole Caenorhabiditis elegans   40   21451522
(R,R)-Cis-Diethyl Tetrahydro-2,8-Chrysenediol Caenorhabiditis elegans 7     24134630
1,2,3,4,6-Penta-O-Galloyl-B-D-Glucose Caenorhabiditis elegans 15.7     24404334
7-Amino-1,2,4-Triazolo- [1,5-A]Pyridine-6,8-Dicarbonitriles Caenorhabiditis elegans 19     22509764
Doxycycline Caenorhabditis elegans 18 17   23698443 24134630
Eliprodil Caenorhabditis elegans 16     24134630
Ellagic Acid Caenorhabditis elegans 10     21805983
Enalapril Rat       19549507
Epigallocatechin Gallate Caenorhabiditis elegans 10.1     19085685
Epigallocatechin Gallate Rat   13.5   23834676
Erbstatin Analogue Drosophila melanogaster 18     22363408
Ethidium Bromide Caenorhabiditis elegans   70   23698443
Trametinib Drosophila melanogaster   12   26119340 http://www.cell.com/cell/abstract/S0092-8674(15)00707-2
Curcumin Caenorhabditis elegans 45     21451522
Curcumin Drosophila melanogaster 19     20645870
Cyclosporin A Caenorhabditis elegans 15     24134630
Cyproterone Acetate Caenorhabditis elegans 23     24134630
Cysteamine Mice 45     11341102
D-Chiro-Inositol Drosophila melanogaster   16.7   22843669
Ethosuximide Caenorhabiditis elegans 17     16606760 18949032
Ethylene-Diamine-Tetra-Acetic Acid Rat 50   25 Komarov, L.V., and Bakaev, V.V. Means of the Life Prolongation, Rejuvenation, 1983, XI: 2-3, 46-51
Euk-134 Caenorhabiditis elegans 38   46 10968795
Euk-8 Caenorhabiditis elegans 52   36 10968795
Everolimus Drosophila melanogaster 16.6     22363408
Fasudil Drosophila melanogaster 14.5     22363408
Fenofibrate Caenorhabiditis elegans 18.52   16.7 23603800
Ferulsinaic Acid Caenorhabiditis elegans 19.6     21749391
Genistein Caenorhabditis elegans 14     25593647
Ggti-298 Drosophila Melanogaster   22   22737247
Glaucarubinone Caenorhabditis elegans 9.5   8.4 21264793
Glutathione Caenorhabditis elegans 73.33     19580823
Glycerol Brachionus manjavacas (Rotifera) 50     24835191
Guanabenz Acetate Caenorhabditis elegans 12     24134630
Guanfacine Hydrochloride Caenorhabditis elegans 15     24134630
Demeclocycline Caenorhabditis elegans 16     24134630
Deprenyl Rat 15     8423709
DHhP-6 Caenorhabditis elegans 21.7     23410029
DHhP-6 Caenorhabditis elegans 21.7   28 20528576
Diazaborine Saccharomyces cerevisiae       18423200
Dibromoacetic Acid Caenorhabiditis elegans 14.6     25556763
Dichloroacetate Caenorhabiditis elegans 19   16 21153705
Didanosine Drosophila melanogaster 5     7518199
D-Glucosamine Caenorhabditis elegans 8   8 24714520
D-Glucosamine Mice       24714520
D-Glucosamine Human       22828954
D-Pinitol Drosophila melanogaster 13     22843669
Dafadine-A Caenorhabditis elegans 29     22057127
Danazol Caenorhabditis elegans 13     24134630
DAPH Caenorhabditis elegans 15     24134630
Dihydroergotamine Methanesulfonate Caenorhabditis elegans 34     24134630
Dihydroergotamine Methanesulfonate Caenorhabditis elegans 24     24134630
Dimebolin Mice 2.5   3.7 21598635
Dimethyl Formamide Caenorhabditis elegans 30     23313473
Dimethyl Sulfoxide Caenorhabditis elegans 24.4     20828537
Doxazosin Mesylate Caenorhabditis elegans 15     24134630
Fisetin Saccharomyces cerevisiae       12939617
Fisetin Caenorhabiditis elegans 5.6     17551714
Fisetin Drosophila melanogaster 23     15254550
Fullerene C60 Rat 90     22498298
Fumarate Caenorhabditis elegans 16     23472183
Gallic Acid Caenorhabditis elegans 10     21805983
Ha-1004 Drosophila melanogaster 18     22363408
Hexahydro-Sila-Difenidol Hydrochloride Caenorhabditis elegans 15     24134630
Ibuprofen Saccharomyces cerevisiae       25521617
Ibuprofen Caenorhabditis elegans   10   25521617
Ibuprofen Drosophila melanogaster   10 0 25521617
Ibuprofen Drosophila melanogaster   10   25521617
Magnesium Human       24259558
Malate Caenorhabditis elegans 14     23472183
Maltose Caenorhabditis elegans 8.18     20477758
Melatonin Mice 18 18   8290600
Metergoline Caenorhabditis elegans 23     24134630
Metformin Caenorhabditis elegans 40   26.1 23540700
Metformin Drosophila melanogaster 0     23077661
Indirubin Drosophila melanogaster 8.2     22363408
Juglone Caenorhabditis elegans 29 62.5   19597959
Kaempferol Caenorhabditis elegans       17551714
Kanamycin Caenorhabditis elegans 24.69   27 18248662
Kenpaullone Caenorhabditis elegans 27     24134630
Ketanserin Tartrate Caenorhabditis elegans 13     24134630
Kinetin Zaprionus paravittiger 20     7488181
Metformin Mice 6     23900241
Methionine Sulfoximine Saccharomyces cerevisiae       16418483
Methiothepin Caenorhabiditis elegans 25     18033297
Methylergonovine Maleate Caenorhabiditis elegans 28     24134630
Metoprolol Mice 10 6.4   23314750
Mianserin Caenorhabiditis elegans 32     18033297 24134630
Minocycline Caenorhabiditis elegans 29     24134630
Kn-93 Drosophila melanogaster 20     22363408
L-Theanine Caenorhabditis elegans 3.1   4.4 22422488
L-744,832 Caenorhabditis elegans   22   22737247
Lamotrigine Drosophila melanogaster 17.2   17.6 19430925
Lfm-A13 Caenorhabditis elegans 27     24134630
Lithium Chloride Caenorhabditis elegans 10     24398558
Lithium Chloride Human       21301855
Naphthazarin Caenorhabditis elegans 13     21765926
Nebivolol Mice 10 6.4   23314750
Nicardipine Hydrochloride Caenorhabditis elegans 23     24134630
Nicotinamide Adenine Dinucleotide Caenorhabditis elegans 15     19370397
Nicotinamide Riboside Saccharomyces cerevisiae       17482543
Nitrendipine Caenorhabditis elegans 25     24134630
Nitroflurbiprofen Mice   12   18631321
Lithocholic Acid Saccharomyces cerevisiae       20622262
Lonidamine Caenorhabditis elegans 8   8 21932172
Loratadine Caenorhabditis elegans 18     24134630
Loxapine Succinate Caenorhabditis elegans 43     24134630
Ly-367,265 Caenorhabditis elegans 34     24134630
Ly294002 Caenorhabditis elegans 10     10638524
Ly294002 Drosophila melanogaster 11.8 14.3 22.5 20017609
Oxatomide Caenorhabditis elegans 25     24134630
Oxoline Caenorhabditis elegans 13   0.1 21765926
Papp Caenorhabditis elegans 33     24134630
Paraquat Caenorhabditis elegans 57.61     21151885
Pd-98059 Drosophila melanogaster 27     22363408
Pergolide Methanesulfonate Caenorhabditis elegans 37     24134630
Minocycline Drosophila melanogaster     46 22330257
Morphine Drosophila melanogaster 15.5     21061062
Myricetin Caenorhabditis elegans 32.9     23736695
Myxothiazol Caenorhabditis elegans 34.62     18221415
N-(2-[4-(4-Chlorophenyl)Piperazin-1-Yl]Ethyl)-3-Methoxybenzamide Caenorhabditis elegans 35     24134630
N-Nitrosodimethylamine Caenorhabditis elegans 5.5     25556763
Naftopidil Dihydrochloride Caenorhabditis elegans 14     24134630
Nordihydroguaiaretic Acid Drosophila melanogaster   23   25380600
Nordihydroguaiaretic Acid Mice   12   18631321
Nortriptyline Hydrochloride Caenorhabditis elegans 21     24134630
Octoclothepin Maleate Caenorhabditis elegans 38     24134630
Oleoylethanolamide Caenorhabditis elegans 15     http://www.sciencemag.org/content/347/6217/83.abstract
Oxaloacetic Acid Caenorhabditis elegans   25 13 19793063
Trehalose Caenorhabiditis elegans 32     20477758
Trequinsin Hydrochloride Caenorhabiditis elegans 27     24134630
Trichostatin A Drosophila melanogaster 27.3   37.9 15346199
Trimethadione Caenorhabiditis elegans 45   58 16606760 18248662 15653505
Tyrosol Caenorhabiditis elegans 19   10.8 22824366
Tyrphostin 1 Drosophila melanogaster 19     22363408
Tyrphostin 9 Drosophila melanogaster 17.3     22363408
Tyrphostin Ag 1295 Drosophila melanogaster 22.5     22363408
Propionylpromazine Hydrochloride Caenorhabditis elegans 20     24134630
Psora-4 Caenorhabditis elegans 42     24134630
Pyrrolidine Dithiocarbamate Drosophila melanogaster   20 14 21483034
Quercetin Caenorhabiditis elegans   21   19043800
Quercetin Dihydrate Drosophila melanogaster 23     22363408
Quercetin-3-O-Glucoside Caenorhabiditis elegans 23     23856528
Quinidine Sulfate Caenorhabiditis elegans 12     24134630
Tyrphostin Ag 1478 Drosophila melanogaster 19.5     22363408 24134630
Tyrphostin Ag 490 Drosophila melanogaster 17.5     22363408
Ursolic Acid Caenorhabiditis elegans 39     http://udini.proquest.com/view/characterization-of-the-antiaging-pqid:1895087761/
Valproic Acid Caenorhabiditis elegans 35   43 18248662
Valpromide Caenorhabiditis elegans 21   35 18248662
Vincristine Sulfate Caenorhabiditis elegans 12     24134630
Vinpocetine Caenorhabiditis elegans 15     24134630
Rosmarinic Acid Caenorhabiditis elegans 10     21503726
Royalactin Caenorhabiditis elegans 33.9     25456847
Royalactin Drosophila melanogaster 18     21516106
Santokvin Mice 20     4927196
Santokvin Mice 32.1     http://link.springer.com/article/10.1007%2FBF02431730
SB203580 Drosophila melanogaster 30.3     22363408
Simvastatin Drosophila melanogaster 25     22737247
Phenformin Mice 23   26 7390164
Phenformin Rat     10 21084729
Phosphonoformic Acid Drosophila melanogaster 5     7518199
Pioglitazone Drosophila melanogaster 3.7     17628757
Polydatin Caenorhabditis elegans 30.7     24305800
Pp2 Drosophila melanogaster 22.8     22363408
Promethazine Hydrochloride Caenorhabditis elegans 32     24134630
Sodium Butyrate Drosophila melanogaster     19 24003736
Sp600125 Drosophila melanogaster 23.5     22363408
Spermidine Saccharomyces cerevisiae       19801973
Spermidine Caenorhabiditis elegans 15     19801973
Spermidine Drosophila melanogaster 30     19801973
Srt1720 Mice 8.8     24582957
Rapamycin Drosophila melanogaster 7   33 20017609
Rapamycin Mice   26 14 24341993
Rapamycin Mice 9     19587680
Rapamycin Mice 13     19587680
Rapamycin Mice 7 11 8 24409289
Rapamycin Mice 14 16 19 24409289
Resveratrol Saccharomyces cerevisiae       12939617
Resveratrol Caenorhabiditis elegans   17.8   16256736
Resveratrol Caenorhabiditis elegans   10   15254550
Resveratrol Drosophila melanogaster 29 13 18 15328413
Resveratrol Drosophila melanogaster 29     15254550
Resveratrol Nothobranchius furzeri   56 59 16461283
Rifampicin Parasarcophaga similis   30   http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ199405019.htm
Rifampicin Caenorhabiditis elegans 45     21451522
Rifampicin Caenorhabiditis elegans 59     25720500
Staurosporine Drosophila melanogaster 34.8     22363408
Su 4312 Caenorhabiditis elegans 5     24134630
Tannic Acid Caenorhabiditis elegans 18   59 21805983 22114686
Thioflavin T Caenorhabiditis elegans   60 78 21451522
Thioridazine Hydrochloride Caenorhabiditis elegans 31     24134630
Vitamin B3 Caenorhabditis elegans 6     24077178
Vitamin B5 Mice 18     13614445
Vitamin D3 Caenorhabiditis elegans 39     24304198
Wortmannin Drosophila melanogaster 4 5 39 20017609
Α-Ketoglutarate Caenorhabditis elegans 50     24828042
Α-Lipoic Acid Drosophila melanogaster 12 15 6 15328413
N-acetyl-L-cysteine Mice     40 20819793
Source: Geroprotectors
Reference: Moskalev, A., Chernyagina, E., de Magalhães, J.P., Barardo, D., Thoppil, H., Shaposhnikov, M., Budovsky, A., Fraifeld, V.E., Garazha, A., Tsvetkov, V. and Bronovitsky, E., 2015. Geroprotectors. org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY), 7(9), p.616.