RGomics (Rejuvenation-Geroinduction). This site catalogues the list of factors that have the potential to rejuvenate (rejuvenin) or to induce aging (geriatrin), evident at the cellular and clinical levels. According to the cell centric hypotheses, the deficits that drive aging occur within cells by age dependent progressive damage to organelles, telomeres, biologic signaling pathways, bioinformational molecules, and by exhaustion of stem cells. We are amending these hypotheses and propose an eco-centric model for the geroplasticity. According to this model, youth and aging are plastic and require constant maintenance, and, respectively, engage a host of endogenous rejuvenating (rejuvenins) and gero-inducing (geriatrin) factors. Aging in this model, is akin to atrophy that occurs as a result of damage or withdrawal of trophic factors. Rejuvenins maintain and geriatrins adversely impact cellular homeostasis, cell fitness, and proliferation, stem cell pools, damage response and repair. Rejuvenins reduce and geriatrins increase the age related disorders, inflammatory signaling, and senescence and reset the epigenetic clock. When viewed through this perspective, aging can be successfully reversed by supplementation with rejuvenins and by reducing the levels of geriatrins.
This platform is dedicated to the creation of databases of rejuvenation (rejuvenins; rejuvenomics) and age inducing (geriatrins; geriatromics) factors. Rejuvenins are all small factors that reverse aging and age related disorders and are capable to reset the epigenetic clock either partially or completely. On the other hand, geriatrins refer to factors that have reverse effects that promote aging. The levels of rejuvenins decline with age whereas geriatrins increase with age. In contrast to all cell-centric hypotheses of aging, the eco-centric hypothesis of aging posits that aging results from an imbalance in the ratios of rejuvenins to geriatrins. NAD+, carnosine, alpha keto-glutrarate (AKG), melatonin and spermidine represent rejuvenins whereas radical oxygen species (ROS) and homocysteine are prototypical geriatrins.
As shown by examples in this platform, the rejuvenins and geriatrins might create interacting networks, akin to the cellular molecular repertories. We hope that once the identity of all rejuvenins and geriatrins are revealed, the ensemble supplementation of lost rejuvenins alone or, with strategies that suppress geriatrins, can lead to effective treatment of aging.
You can use the public dashboard and view rejuvenin and geriatrin databases. You can use your private dashboard to add rejuvenins and geriatrins of your own interest to this platform. To acccess your private dashboard, please register and if you have registered, login to gain access. We encourage all scientists to participate in extending this database that has the promise in allowing us to reset the aging clock and reverse aging.