| Name of Formulation | Dose |
Avg/Med Lifespan Change (%) -96267.9 |
Max Lifespan Change (%) -94.993 |
Strain | Significance (Yes: Y, No: N) | Reference |
| Indolepropionamide | 30 µM | >267.9 | odiosa | Y | 20421998 | |
| Indolepropionamide | 20 µM | >229.7 | odiosa | Y | 20421998 | |
| Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate | 1.25 µM | >157.3 | Y | 25190068 | ||
| Indolepropionamide | 10 µM | >137.8 | odiosa | Y | 20421998 | |
| Aspirin | 5.65x10^5 g aspirin/g food | >134 | Y | 25833406 | ||
| Aspirin | 2.263x10^4 g aspirin/g food | >111 | Y | 25833406 | ||
| SkQ1 | 0.55 nM | >100 | Y | 19120018 | ||
| Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate | 2.5 µM | >98.6 | Y | 25190068 | ||
| Kinetin | 25 ppm | >80 | >19.7 | Y | 7488181 | |
| Metformin | 1.78x10^3 g metformin/g diet | >79 | Y | 25833406 | ||
| Aspirin | 2.263x10^4 g aspirin/g food | >77 | Y | 25833406 | ||
| EGTA | 0.25% on alternate days | >75.9 | ND | 804507 | ||
| Aspirin | 5.65x10^5 g aspirin/g food | >67 | Y | 25833406 | ||
| Nordihydroguaiaretic acid | 0.005% (w/v) | >64.3 | Y | 3749035 | ||
| Resveratrol | 600 µg/g food | >56 | >59 | Gonarezhou | Y | 16461283 |
| Aspirin | 5.65x10^5 g aspirin/g food | >52 | Y | 25833406 | ||
| Citrate | 0.25% on alternate days | >51.7 | ND | 804507 | ||
| Glycerol | 274 mM | >51 | Y | 24835191 | ||
| SkQ1 | 100 nM | >50 | Y | 19120018 | ||
| Edetate Calcium Disodium | 0.25% on alternate days | >49.4 | ND | 804507 | ||
| Aspirin | 2.263x10^4 g aspirin/g food | >49 | Y | 25833406 | ||
| EUK-134 | 3.1 µM | >48.8 | Y | 25190068 | ||
| Tartrate | 0.25% on alternate days | >43.7 | ND | 804507 | ||
| Oregano and Cranberry extracts | 0.02 | >43 | Loew | Y | 21455602 | |
| Resveratrol | 12 µg | >42.9 | >17 | Y | 23220248 | |
| Nordihydroguaiaretic acid | 0.001% (w/v) | >42.7 | Y | 3749035 | ||
| Metformin | 1.78x10^3 g metformin/g diet | >39 | Y | 25833406 | ||
| Resveratrol | 30 µM | >38 | Y | 22868943 | ||
| Curare | 0.00% | >34 | Y | 3833547 | ||
| N-Acetyl Cysteine | 10 nM | >32.4 | >8.6 | Y | 30243020 | |
| Curare | 0.00% | >32 | Y | 3833547 | ||
| N-Acetyl Cysteine | 100 nM | >31 | >8.69 | Y | 30243020 | |
| N-Acetyl Cysteine | 1 µM | >31 | >7.6 | Y | 30243020 | |
| N-Acetyl Cysteine | 100 µM | >31 | >7.6 | Y | 30243020 | |
| N-Acetyl Cysteine | 1 mM | >31 | >2.9 | Y | 30243020 | |
| N-Acetyl Cysteine | 10 µM | >29.6 | >7.6 | Y | 30243020 | |
| Sodium hypophosphite | 1 mM | >28.5 | >34.3 | Y | 3721207 | |
| Sodium hypophosphite | 1 mM | >28.1 | >27 | Y | 3721207 | |
| Butylated hydroxyanisole | 10 mM | >27 | >17.6 | Y | 9207858 | |
| EUK-134 | 1.6 µM | >26.4 | Y | 25190068 | ||
| Butylated hydroxytoluene | 1000 µM | >26.1 | Y | 6656301 | ||
| Curare | 0.00% | >26 | Y | 3833547 | ||
| N-Acetyl Cysteine | 100 µM | >26 | >9.8 | Y | 30243020 | |
| Sodium hypophosphite | 5 mM | >25.4 | >19.7 | Y | 3721207 | |
| Sodium hypophosphite | 100 µM | >24.9 | >22.9 | Y | 3721207 | |
| Vitamin E | 3 mM | >24.5 | clone 4B61 | Y | 15374519 | |
| N-Acetyl Cysteine | 1 mM | >24 | >8.8 | Y | 30243020 | |
| Sodium hypophosphite | 5 mM | >23.6 | >21.9 | Y | 3721207 | |
| Resveratrol | 100 µL | >23 | >32 | TZ 97-2 | Y | 22960591 |
| Kinetin | 125 ppm | >22.9 | >15.8 | Y | 7488181 | |
| Melatonin | 10 mg/L | >22.8 | >20.9 | Y | 9406982 | |
| N-Acetyl Cysteine | 10 µM | >22.7 | >6.9 | Y | 30243020 | |
| N-Acetyl Cysteine | 10 nM | >22.6 | >6.9 | Y | 30243020 | |
| Vitamin E | 25 µg/mL | >21 | Y | 6479253 | ||
| Cortisone | 100 µM | >20.8 | >0 | clone 4B61 | Y | 2782995 |
| Melatonin | 10 mg/L | >20.8 | >14.8 | Y | 9406982 | |
| Butylated hydroxyanisole | 25 mM | >20.5 | >2.2 | Y | 9207858 | |
| EUK-134 | 12.5 µM | >20.2 | Y | 25190068 | ||
| Cortisone | 200 µM | >19.3 | >0 | clone 4B61 | Y | 2782995 |
| Butylated hydroxytoluene | 1000 µM | >19 | Y | 6656301 | ||
| Resveratrol | 200 µg/g | >19 | TZ 97-2 | Y | 25569124 | |
| N-Acetyl Cysteine | 100 nM | >18.7 | >4.9 | Y | 30243020 | |
| Butylated hydroxyanisole | 5 mM | >18.4 | >6.6 | Y | 9207858 | |
| Sodium hypophosphite | 100 µM | >18 | >21 | Y | 3721207 | |
| Vitamin E | 3 mM | >16.4 | >6.7 | clone 4B61 | Y | 15374519 |
| 3,3'-thiodipropionic acid | 2 mM | >16.4 | clone 4B61 | Y | 15374519 | |
| N-Acetyl Cysteine | 100 µM | >16 | >13.9 | Y | 30243020 | |
| N-Acetyl Cysteine | 1 mM | >16 | >13.9 | Y | 30243020 | |
| N-Acetyl Cysteine | 1 µM | >16 | >11.1 | Y | 30243020 | |
| N-Acetyl Cysteine | 10 µM | >16 | >0 | Y | 30243020 | |
| N-Acetyl Cysteine | 1 µM | >16 | >6.9 | Y | 30243020 | |
| Resveratrol | 100 µM | >15.6 | >22.5 | Y | 19264118 | |
| Butylated hydroxyanisole | 10 mM | >15.1 | >27 | Y | 9207858 | |
| Propyl gallate | 25 µg/ml | >15.1 | >12.2 | Y | 8950031 | |
| Butylated hydroxytoluene | 100 µM | >14.3 | Y | 6656301 | ||
| Kinetin | 25 ppm | >14.2 | >12.9 | Y | 7488181 | |
| Acanthophora spicifera extract | 5 µg/ml | >14 | Y | 24120568 | ||
| Resveratrol | 200 µg/g | >14 | TZ 97-2 | Y | 25569124 | |
| Naproxen | 1 µM | >13.93 | >5.56 | Y | 27484416 | |
| Nordihydroguaiaretic acid | 0.01% (w/v) | >13.6 | N | 3749035 | ||
| Sodium hypophosphite | 10 µM | >13.2 | >12.4 | Y | 3721207 | |
| Butylated hydroxyanisole | 25 mM | >13.1 | >4.4 | Y | 9207858 | |
| Sodium hypophosphite | 10 µM | >13 | >13.3 | Y | 3721207 | |
| Butylated hydroxytoluene | 100 µM | >13 | Y | 6656301 | ||
| Resveratrol | 100 µL | >13 | >23 | TZ 97-2 | Y | 22960591 |
| Ascorbic acid | 50 mg/L | >12.1 | >6.7 | ND | 9406982 | |
| N-Acetyl Cysteine | 100 nM | >12 | >8.3 | Y | 30243020 | |
| Nordihydroguaiaretic acid | 0.001% (w/v) | >11.9 | N | 3749035 | ||
| Vitamin E | 25 mg/L | >11.7 | >17.1 | ND | 9406982 | |
| Resveratrol | 100 µM | >11.2 | >-1.4 | N | 19264118 | |
| Melatonin | 10 mg/L | >10.8 | >5.1 | ND | 9406982 | |
| 3,3'-thiodipropionic acid | 2 mM | >10 | >0 | clone 4B61 | Y | 15374519 |
| Vitamin E | concentration of 10^ -4 | >9.2 | >0 | N | 7428854 | |
| Jania acutilobum extract | 5 µg/ml | >9.1 | Y | 24120568 | ||
| Hydralazine | 1 µM | >9.01 | >0 | Y | 27484416 | |
| Propyl gallate | 25 µg/ml | >8.7 | >15.3 | Y | 8950031 | |
| Recombinant GDF11 | 0.2 mg/kg | >8.51 | >7.69 | Y | 30519861 | |
| Peyssonnelia sp. extract | 2 µg/ml | >8.5 | Y | 24120568 | ||
| Rotenone | 15 pM | >8.1 | MZM-0410 | Y | 27135165 | |
| Resveratrol | 100 µM | >8 | >36.3 | N | 19264118 | |
| N-Acetyl Cysteine | 10 nM | >8 | >19.4 | Y | 30243020 | |
| Butylated hydroxyanisole | 5 mM | >7.9 | >6.9 | Y | 9207858 | |
| Nordihydroguaiaretic acid | 0.005% (w/v) | >6.7 | N | 3749035 | ||
| Resveratrol | 100 µM | >6.2 | >7.3 | N | 19264118 | |
| Sodium hypophosphite | 1 µM | >5.3 | >5.7 | Y | 3721207 | |
| N-Acetyl Cysteine | 10 nM | >5.1 | >0 | Y | 30243020 | |
| N-Acetyl Cysteine | 100 nM | >5.1 | >-2 | Y | 30243020 | |
| Butylated hydroxytoluene | 10 µM | >4.8 | Y | 6656301 | ||
| Butylated hydroxytoluene | 10 µM | >4.3 | Y | 6656301 | ||
| Butylated hydroxyanisole | 1 mM | >4 | >1.3 | N | 9207858 | |
| Resveratrol | 100 µM | >3.8 | >5.7 | N | 19264118 | |
| Rhodiola rosea | >2.7 | >2.7 | N4 | Y | 26497336 | |
| Resveratrol | 100 µM | >2.6 | >17.5 | N | 19264118 | |
| Resveratrol | 100 µM | >2.6 | >13.9 | N | 19264118 | |
| Resveratrol | 100 µM | >2.5 | >-7.7 | N | 19264118 | |
| Resveratrol | 100 µM | >2.3 | >5 | N | 19264118 | |
| Cortisone | 50 µM | >2.2 | >0 | clone 4B61 | N | 2782995 |
| Butylated hydroxyanisole | 1 mM | >1.7 | >0.8 | N | 9207858 | |
| Resveratrol | 100 µM | >1.5 | >10 | N | 19264118 | |
| Rhodiola rosea | >1.5 | >1.6 | N4 | Y | 26497336 | |
| Resveratrol | 100 µM | >1.3 | >16.6 | N | 19264118 | |
| Sodium hypophosphite | 1 µM | >1 | >6 | Y | 3721207 | |
| Cortisone | 10 µM | >0.7 | >0 | clone 4B61 | N | 2782995 |
| Resveratrol | 100 µM | >0 | >-3.4 | N | 19264118 | |
| Resveratrol | 3 µM | >0 | N | 24133070 | ||
| Resveratrol | 0.3 µM | >0 | N | 24133070 | ||
| Resveratrol | 100 µM | >-0.5 | >3.7 | N | 19264118 | |
| Resveratrol | 100 µM | >-1.4 | >-12 | N | 19264118 | |
| Resveratrol | 100 µM | >-2.3 | >26.5 | N | 19264118 | |
| Resveratrol | 100 µM | >-2.3 | >16.7 | N | 19264118 | |
| Resveratrol | 100 µM | >-2.8 | >-4.8 | N | 19264118 | |
| Kinetin | 125 ppm | >-2.9 | >17.1 | Y | 7488181 | |
| Kinetin | 625 ppm | >-2.9 | >-13.2 | Y | 7488181 | |
| Cortisone | 400 µM | >-3.2 | >0 | clone 4B61 | N | 2782995 |
| Resveratrol | 100 µM | >-3.3 | >-12.1 | N | 19264118 | |
| Sodium hypophosphite | 10 mM | >-4.1 | >-1.4 | N | 3721207 | |
| Resveratrol | 100 µM | >-4.6 | >-12.4 | N | 19264118 | |
| Resveratrol | 100 µM | >-4.9 | >5.4 | N | 19264118 | |
| Resveratrol | 100 µM | >-5.6 | >10.2 | N | 19264118 | |
| Resveratrol | 100 µM | >-5.8 | >-7.3 | N | 19264118 | |
| Cortisone | 800 µM | >-6.3 | >0 | clone 4B61 | N | 2782995 |
| Resveratrol | 0.3 µM | >-6.5 | N | 24133070 | ||
|
Sodium
hypophosphite |
10 mM |
>-8.3 |
>-1.7 |
Y |
3721207 |
|
|
Resveratrol |
100 µM |
>-14.5 |
>-14.4 |
N |
19264118 |
|
|
Galactose |
20 mg/ml |
>-19.8 |
>-21.9 |
Y |
15547319 |
|
|
Kinetin |
625 ppm |
>-20 |
>0 |
N |
7488181 |
|
|
Rotenone |
150 pM |
>-20.09 |
MZM-0410 |
Y |
27190265 |
|
|
Curare |
0.00% |
>-24 |
Y |
3833547 |
||
|
2-Oxothiazolidine-4-carboxylate |
3 mM |
>-24 |
Y |
2866912 |
||
|
Sodium hypophosphite |
60 mM |
>-24.2 |
>-8.1 |
Y |
3721207 |
|
|
Sodium
hypophosphite |
60 mM |
>-24.4 |
>-11.2 |
Y |
3721207 |
|
|
Resveratrol |
100 µM |
>-25.3 |
>-9.5 |
Y |
19264118 |
|
|
Galactose |
20 mg/ml |
>-27.1 |
>-27.1 |
Y |
15547319 |
|
|
Buthionine
Sulfoximine |
3 mM |
>-30 |
Y |
2866912 |
||
|
Butylated
hydroxyanisole |
50 mM |
>-31.7 |
>-46.3 |
Y |
9207858 |
|
|
Resveratrol |
3 µM |
>-32.3 |
Y |
24133070 |
||
|
Butylated
hydroxyanisole |
50 mM |
>-45.9 |
>-40.7 |
Y |
9207858 |
|
|
Sodium hypophosphite |
100 mM |
>-46.9 |
>-47.2 |
Y |
3721207 |
|
|
Butylated
hydroxyanisole |
100 mM |
>-57.2 |
>-55.2 |
Y |
9207858 |
|
|
Sodium
hypophosphite |
100 mM |
>-58.8 |
>-54.8 |
Y |
3721207 |
|
|
Butylated
hydroxyanisole |
100 mM |
>-63.8 |
>-53.7 |
Y |
9207858 |
|
|
Kinetin |
3125 ppm |
>-65.7 |
>-55.2 |
Y |
7488181 |
|
|
Kinetin |
3125 ppm |
>-71 |
>-47.1 |
Y |
7488181 |
|
|
Sodium
hypophosphite |
500 mM |
>-84.1 |
>-78.1 |
Y |
3721207 |
|
|
Sodium hypophosphite |
500 mM |
>-85.3 |
>-78.6 |
Y |
3721207 |
|
|
Sodium
hypophosphite |
1 mM |
>-88.5 |
>-91.4 |
Y |
3721207 |
|
|
Sodium
hypophosphite |
1 mM |
>-89.8 |
>-94.9 |
Y |
3721207 |
|
|
Powdered
Broccoli Lyophilisate |
1% |
San
Bernardino |
Y |
23321956 |
||
|
L-deprenyl |
1 mg/kg |
Beagles |
ND |
9307048 |
||
|
L-deprenyl |
0.05
mg/kg/day |
>16.4 |
Y |
9258898 |
||
|
Melatonin |
10 mg/L |
>17.9 |
N |
9406982 |
||
| Reference: HAGR |