Age induced gene changes; homosapiens -3
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Gene Symbol (Name) Description Change gender Age change starts Age change ends Tissues Percentage change P value References
HOXC6 (homeobox C6) Using a linear mixed model, differential expression with age was identified in HOXC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HOXC8 (homeobox C8) Using a linear mixed model, differential expression with age was identified in HOXC8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HOXD12 (homeobox D12) Using a linear mixed model, differential expression with age was identified in HOXD12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HPCAL1 (hippocalcin-like 1) Using a linear mixed model, differential expression with age was identified in HPCAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HPN (hepsin)   Male and Female 22 73 Skeletal Muscle 4.0   2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
HPS4 (Hermansky-Pudlak syndrome 4) Using a linear mixed model, differential expression with age was identified in HPS4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HS3ST2 (heparan sulfate (glucosamine) 3-O-sulfotransferase 2) Using a linear mixed model, differential expression with age was identified in HS3ST2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hsbp1 (heat shock factor binding protein 1)   Male and Female 8 24 Muscle -2.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1) Using a linear mixed model, differential expression with age was identified in HSD11B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10) Using a linear mixed model, differential expression with age was identified in HSD17B10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10) Using a linear mixed model, differential expression with age was identified in HSD17B10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD17B13 (hydroxysteroid (17-beta) dehydrogenase 13) Using a linear mixed model, differential expression with age was identified in HSD17B13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD17B2 (hydroxysteroid (17-beta) dehydrogenase 2) Using a linear mixed model, differential expression with age was identified in HSD17B2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7)   Male and Female 8 24 Muscle 4.0   2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) Using a linear mixed model, differential expression with age was identified in HSD3B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7) Using a linear mixed model, differential expression with age was identified in HSD3B7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of HSD3B7 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
HSF1 (heat shock transcription factor 1)   Male and Female 20 75 Skeletal Muscle -5.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HSF4 (heat shock transcription factor 4) Using a linear mixed model, differential expression with age was identified in HSF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Hsfy2 (heat shock transcription factor, Y linked 2)   Male and Female 5 22 Brain -81.0   2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1)   Male and Female 5 30 Anatomical System -1.0   2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
HSP90AB1 (heat shock protein 90kDa alpha (cytosolic), class B member 1)   Male and Female 26 106 Brain -5.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
HSPA12A (heat shock 70kDa protein 12A) Using a linear mixed model, differential expression with age was identified in HSPA12A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HSPA1A (heat shock 70kDa protein 1A)   Male and Female 20 75 Skeletal Muscle 4.0   2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
HSPA2 (heat shock 70kDa protein 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of HSPA2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
HSPA8 (heat shock 70kDa protein 8)   Male and Female 26 106 Brain -7.0   2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1) Using a linear mixed model, differential expression with age was identified in HSPBAP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HTATSF1 (HIV-1 Tat specific factor 1) Using a linear mixed model, differential expression with age was identified in HTATSF1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled) Using a linear mixed model, differential expression with age was identified in HTR2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of HTR7 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
HTRA1 (HtrA serine peptidase 1) Using a linear mixed model, differential expression with age was identified in HTRA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85
Reference: Source: AmiGo 2