|
Entrez Id |
Gene Symbol |
Method |
Senescence Type |
Effect on senescence |
Cell Types |
Cell Lines |
Cancer Line |
|
3400 |
Overexpression |
Stress-induced |
Induction |
Prostate cancer |
DU145 |
Yes |
|
|
5824 |
Overexpression |
Stress-induced |
Induction |
Osteosarcoma |
U2OS |
Yes |
|
|
8553 |
Overexpression |
Replicative, Stress-induced |
Induction |
Breast cancer, Esophageal cancer |
EC9706, MCF-7 |
Yes |
|
|
7157 |
Overexpression |
Replicative, Stress-induced |
Induction |
Bladder cancer |
EJ |
Yes |
|
|
80019 |
Overexpression |
Replicative, Stress-induced |
Induction |
Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer |
AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16 |
Yes |
|
|
51225 |
Overexpression |
Replicative |
Induction |
Colon cancer, Thyroid cancer |
ARO, WRO |
Yes |
|
|
203054 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
247 |
Overexpression |
Replicative |
Induction |
Prostate epithelial |
Primary cell |
No |
|
|
10095 |
Overexpression |
Replicative |
Induction |
Osteosarcoma |
SaOs-2 |
Yes |
|
|
558 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
640 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
595 |
Overexpression |
Replicative |
Induction |
Fibroblast |
Hs68, WI-38 |
No |
|
|
5129 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
1027 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
TIG-3 |
No |
|
|
1028 |
Overexpression |
Replicative |
Induction |
Liver cancer |
HepG2, SNU-398 |
Yes |
|
|
1029 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
TIG-3 |
No |
|
|
55602 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
MRC-5, TIG-1 |
No |
|
|
1030 |
Overexpression |
Replicative |
Induction |
Glioblastoma |
T98G, U-251MG, U-373MG |
Yes |
|
|
1152 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
3576 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90, WI-38 |
No |
|
|
3491 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90 |
No |
|
|
1869 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
26298 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
54206 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
10922 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
79791 |
Overexpression |
Replicative |
Induction |
Breast cancer |
MCF-7 |
Yes |
|
|
56287 |
Overexpression |
Replicative |
Induction |
Gastric cancer |
AGS, MKN1 |
Yes |
|
|
2870 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
3065 |
Overexpression |
Replicative |
Induction |
Cervical cancer |
HeLa |
Yes |
|
|
220296 |
Overexpression |
Replicative |
Induction |
Breast cancer |
MCF-7 |
Yes |
|
|
3101 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
3458 |
Overexpression |
Replicative |
Induction |
Umbilical vein endothelial |
Primary cell |
No |
|
|
3484 |
Overexpression |
Replicative |
Induction |
Breast cancer |
MCF-7 |
Yes |
|
|
3621 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast |
Hs68 |
No |
|
|
3661 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
3663 |
Overexpression |
Replicative |
Induction |
Li Fraumeni syndrome fibroblast |
MDAH041 |
Yes |
|
|
3665 |
Overexpression |
Replicative |
Induction |
Li Fraumeni syndrome fibroblast |
MDAH041 |
Yes |
|
|
3705 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
3707 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
3984 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
5604 |
Overexpression |
Replicative |
Induction |
Intestinal epithelial |
HIEC-6 |
No |
|
|
5608 |
Overexpression |
Replicative |
Induction |
Osteosarcoma |
U2OS |
Yes |
|
|
5609 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
9064 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
6885 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
6300 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
22983 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
4145 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
10445 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast, Mammary epithelial |
H184B5F5/M10, Hs68, IMR-90 |
No |
|
|
126308 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
23515 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
10934 |
Overexpression |
Replicative |
Induction |
Fibrosarcoma |
A9, HT1080 |
Yes |
|
|
4598 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
10608 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
65220 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
4814 |
Overexpression |
Replicative |
Induction |
Hepatoma |
Huh7 |
Yes |
|
|
5015 |
Overexpression |
Replicative |
Induction |
Medulloblastoma |
D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2 |
Yes |
|
|
10298 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
149420 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
5170 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
23037 |
Overexpression |
Replicative |
Induction |
Breast cancer, Liver cancer, Prostate cancer |
DU145 |
Yes |
|
|
51588 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
23533 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
5315 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
10654 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
87178 |
Overexpression |
Replicative |
Induction |
Melanoma |
FO-1, HO-1, MeWo |
Yes |
|
|
5460 |
Overexpression |
Replicative |
Induction |
Mesenchymal stromal |
Primary cell |
No |
|
|
5629 |
Overexpression |
Replicative |
Induction |
Liver cancer |
Hep3B, HepG2, Mahlavu, SK-HEP1 |
Yes |
|
|
9232 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90, WI-38 |
No |
|
|
861 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast |
Hs68 |
No |
|
|
150094 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
64849 |
Overexpression |
Replicative |
Induction |
Lung fibroblast, Renal tubular |
MRC-5, WI-38 |
No |
|
|
6598 |
Overexpression |
Replicative |
Induction |
Malignant rhabdoid tumor |
G-401 |
Yes |
|
|
64750 |
Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast, Skin fibroblast |
BJ, WI-38, WS1 |
No |
|
|
8470 |
Overexpression |
Replicative |
Induction |
Fibroblast, Keratinocyte |
Primary cell |
No |
|
|
6657 |
Overexpression |
Replicative |
Induction |
Colon cancer, Embryonic kidney |
HCT116, HEK293T, WiDr |
Yes |
|
|
6667 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
2BS |
No |
|
|
10927 |
Overexpression |
Replicative |
Induction |
Cervical cancer |
HeLa |
Yes |
|
|
6720 |
Overexpression |
Replicative |
Induction |
Fibroblast |
Primary cell |
No |
|
|
6777 |
Overexpression |
Replicative |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
282974 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
83931 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
6850 |
Overexpression |
Replicative |
Induction |
Melanoma |
501-mel, A375, SK-MEL-28 |
Yes |
|
|
7023 |
Overexpression |
Replicative |
Induction |
Breast cancer, Retinal pigment epithelial |
hTERT-RPE, MCF-7 |
Yes |
|
|
7098 |
Overexpression |
Replicative |
Induction |
Fibroblast, Keratinocyte |
Primary cell |
No |
|
|
7297 |
Overexpression |
Replicative |
Induction |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|
|
7538 |
Overexpression |
Replicative |
Induction |
Cervical cancer |
HeLa |
Yes |
|
|
207 |
Overexpression |
Oncogene-induced |
Induction |
Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial |
Primary cell |
No |
|
|
673 |
Overexpression |
Oncogene-induced |
Induction |
Foreskin fibroblast, Melanocyte |
BJ, Primary cell |
No |
|
|
2919 |
Overexpression |
Oncogene-induced |
Induction |
Ovarian fibroblast |
Gro-1 |
No |
|
|
2113 |
Overexpression |
Oncogene-induced |
Induction |
Foreskin fibroblast, Lung fibroblast |
Hs68, TIG-3 |
No |
|
|
2114 |
Overexpression |
Oncogene-induced |
Induction |
Foreskin fibroblast, Lung fibroblast |
Hs68, TIG-3 |
No |
|
|
3265 |
Overexpression |
Oncogene-induced |
Induction |
Lung fibroblast |
IMR-90, WI-38 |
No |
|
|
5605 |
Overexpression |
Oncogene-induced |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
5371 |
Overexpression |
Oncogene-induced |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
5894 |
Overexpression |
Oncogene-induced |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
2810 |
Overexpression |
Oncogene-induced |
Induction |
Melanoma |
SK-MEL-147, SK-MEL-19, SK-MEL-29 |
Yes |
|
|
6660 |
Overexpression |
Oncogene-induced |
Induction |
Glioma |
U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa |
Yes |
|
|
6426 |
Overexpression |
Oncogene-induced |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
1718 |
Mutation |
Oncogene-induced |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
183 |
Knockout, Overexpression |
Replicative |
Induction |
Vascular smooth muscle |
Primary cell |
No |
|
|
25842 |
Knockout, Overexpression |
Oncogene-induced, Replicative |
Induction |
Lung fibroblast |
Primary cell |
No |
|
|
64506 |
Knockout, Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
Primary cell, WI-38 |
No |
|
|
2791 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
TIG-7 |
No |
|
|
3488 |
Knockout, Overexpression |
Replicative |
Induction |
Umbilical vein endothelial |
Primary cell |
No |
|
|
3622 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
MRC-5 |
No |
|
|
9891 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
7703 |
Knockout, Overexpression |
Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
BJ, MRC-5, WI-38 |
No |
|
|
22925 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
IMR-90, WI-38 |
No |
|
|
6041 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
26156 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
2BS |
No |
|
|
23309 |
Knockout, Overexpression |
Replicative |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
7041 |
Knockout, Overexpression |
Replicative |
Induction |
Fibroblast |
KMST-6, SUSM-1 |
No |
|
|
9966 |
Knockout, Overexpression |
Replicative |
Induction |
Endothelial progenitor |
Primary cell |
No |
|
|
10628 |
Knockout, Overexpression |
Oncogene-induced, Replicative |
Induction |
Lung fibroblast |
2BS |
No |
|
|
1026 |
Knockout |
Replicative |
Induction |
Fibroblast |
LF1 |
No |
|
|
1111 |
Knockout |
Stress-induced |
Induction |
Colon cancer |
HCT116 |
Yes |
|
|
1643 |
Knockout |
Oncogene-induced |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
2130 |
Knockout |
Replicative |
Induction |
Hematopoietic stem |
Primary cell |
No |
|
|
3552 |
Knockout |
Replicative |
Induction |
Umbilical vein endothelial |
Primary cell |
No |
|
|
1432 |
Knockout |
Replicative, Stress-induced |
Induction |
Lung fibroblast |
MRC-5, WI-38 |
No |
|
|
8550 |
Knockout |
Oncogene-induced |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
11235 |
Knockout |
Oncogene-induced, Replicative |
Induction |
Coronary artery endothelial, Lung fibroblast |
IMR-90, Primary cell |
No |
|
|
7150 |
Knockout |
Replicative |
Induction |
Lung fibroblast |
IMR-90, WI-38 |
No |
|
|
8626 |
Knockout |
Replicative |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
10155 |
Knockout |
Oncogene-induced |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
367 |
Knockdown, Overexpression |
Replicative |
Induction |
Hair follicular keratinocyte |
Primary cell |
No |
|
|
284119 |
Knockdown, Overexpression |
Replicative |
Induction |
Cervical cancer, Lung fibroblast |
HeLa, IMR-90, WI-38 |
No |
|
|
1051 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Prostate cancer |
LNCaP |
Yes |
|
|
2626 |
Knockdown, Overexpression |
Replicative, Stress-induced |
Induction |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90 |
No |
|
|
50618 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Foreskin fibroblast, Lung fibroblast |
Hs68, WI-38 |
No |
|
|
50507 |
Knockdown, Overexpression |
Replicative |
Induction |
Breast epithelial, Lung fibroblast |
MCF-12A, TIG-3 |
No |
|
|
5037 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Colon cancer, Gastric cancer, Lung cancer, Prostate cancer |
A549, HCT116, MKN45, PC-3 |
Yes |
|
|
5292 |
Knockdown, Overexpression |
Oncogene-induced, Replicative |
Induction |
Foreskin fibroblast, Lung fibroblast |
2BS, BJ, WI-38 |
No |
|
|
5580 |
Knockdown, Overexpression |
Replicative |
Induction |
Lung fibroblast |
TIG-1 |
No |
|
|
5583 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Breast cancer |
MCF-7 |
Yes |
|
|
27330 |
Knockdown, Overexpression |
Replicative |
Induction |
Colon cancer, Lung fibroblast |
IMR-90 |
No |
|
|
8651 |
Knockdown, Overexpression |
Oncogene-induced, Replicative |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
8405 |
Knockdown, Overexpression |
Replicative |
Induction |
Lung fibroblast |
IMR-90 |
No |
|
|
27287 |
Knockdown, Overexpression |
Replicative |
Induction |
Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma |
HEK293T, HeLa, IMR-90, Nalm16, U2OS |
Yes |
|
|
54739 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Dermal microvascular endothelial cells |
Primary cell |
No |
|
|
83719 |
Knockdown, Overexpression |
Stress-induced |
Induction |
Breast cancer |
MCF-7 |
Yes |
|
|
29117 |
Knockdown |
Replicative |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
857 |
Knockdown |
Replicative |
Induction |
Fibroblast |
Primary cell |
No |
|
|
3486 |
Knockdown |
Stress-induced |
Induction |
Lung fibroblast |
WI-38 |
No |
|
|
3691 |
Knockdown |
Replicative |
Induction |
Umbilical vein endothelial |
Primary cell |
No |
|
|
10397 |
Knockdown |
Replicative |
Induction |
Liver cancer |
Hep3B, HepG2, Huh7, PLC/PRF/5 |
Yes |
|
|
6787 |
Knockdown |
Replicative, Stress-induced |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
4854 |
Knockdown |
Stress-induced |
Induction |
Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma |
A375P, BJ, LF1, MDA-MB-231, T98G, WS1 |
Yes |
|
|
55193 |
Knockdown |
Replicative |
Induction |
Foreskin fibroblast |
BJ |
No |
|
|
5925 |
Knockdown |
Stress-induced |
Induction |
Osteoblast |
Primary cell |
No |
|
|
5054 |
Knockdown |
Replicative |
Induction |
Foreskin fibroblast |
BJ, Primary cell |
No |
|
|
51384 |
Knockdown |
Replicative |
Induction |
Lung fibroblast |
MRC-5 |
No |
|
| Reference: HAGR |