| Entrez ID | Symbol | Method Used To Cause Senescence | Cell type | Cell line | Cancer Line | ||
| 47 | ACLY | Knockout | Dermal fibroblast | Primary cell | No | ||
| 444 | ASPH | Knockdown | Liver cancer | FOCUS, HepG2, Huh7 | Yes | ||
| 472 | ATM | Knockout | Foreskin fibroblast, Lung fibroblast | BJ, MRC-5, WI-38 | No | ||
| 6790 | AURKA | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 9531 | BAG3 | Knockdown | Glioma, Laryngeal cancer | A172, HEp2 | Yes | ||
| 604 | BCL6 | Overexpression | B-cell | Primary cell | No | ||
| 648 | BMI1 | Knockout, Overexpression | Foreskin fibroblast, Lung fibroblast, Skin fibroblast | 82-6, BJ, WI-38 | No | ||
| 10950 | BTG3 | Knockdown | Lung fibroblast | IMR-90, WI-38 | No | ||
| 23492 | CBX7 | Knockdown, Overexpression | Keratinocyte, Lung fibroblast | Primary cell, WI-38 | No | ||
| 57332 | CBX8 | Overexpression | Fibroblast | TIG-3 | No | ||
| 983 | CDK1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 8099 | CDK2AP1 | Knockdown | Dermal fibroblast | Primary cell | No | ||
| 1019 | CDK4 | Overexpression | Foreskin fibroblast | BJ | No | ||
| 1021 | CDK6 | Overexpression | Foreskin fibroblast | BJ | No | ||
| 1058 | CENPA | Knockdown | Lung fibroblast | TIG-3 | No | ||
| 1452 | CSNK1A1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 1457 | CSNK2A1 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 8727 | CTNNAL1 | Knockdown | Lung cancer, Squamous carcinoma | A549, OC2 | Yes | ||
| 7913 | DEK | Overexpression | Foreskin keratinocyte | Primary cell | No | ||
| 54487 | DGCR8 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 1660 | DHX9 | Knockdown | Lung fibroblast | MRC-5 | No | ||
| 1746 | DLX2 | Overexpression | Foreskin fibroblast, Lung fibroblast | BJ, IMR-90 | No | ||
| 84661 | DPY30 | Knockout | Lung fibroblast | IMR-90 | No | ||
| 80824 | DUSP16 | Knockdown | Embryonic kidney, Liver cancer | HEK293FT, HepG2, PLC/PRF/5 | Yes | ||
| 1845 | DUSP3 | Knockdown | Cervical cancer | HeLa | Yes | ||
| 2021 | ENDOG | Knockdown | Endothelial | Primary cell | No | ||
| 2042 | EPHA3 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 2353 | FOS | Overexpression | Lung fibroblast | WI-38 | No | ||
| 2305 | FOXM1 | Knockdown | Gallbladder cancer | GBC-SD | Yes | ||
| 2309 | FOXO3 | Knockdown | Dermal fibroblast | Primary cell | No | ||
| 8087 | FXR1 | Knockdown, Overexpression | Laryngeal cancer, Tongue cancer | CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B | Yes | ||
| 2539 | G6PD | Knockout | Foreskin fibroblast | Primary cell | No | ||
| 2597 | GAPDH | Knockdown | Lung cancer | A549 | Yes | ||
| 2720 | GLB1 | Knockdown | Foreskin fibroblast | Primary cell | No | ||
| 9759 | HDAC4 | Knockout, Overexpression | Lung fibroblast | 2BS | No | ||
| 3096 | HIVEP1 | Knockdown | Foreskin fibroblast | Primary cell | No | ||
| 55355 | HJURP | Knockdown, Overexpression | Dermal fibroblast, Umbilical vein endothelial | Primary cell | No | ||
| 3146 | HMGB1 | Knockdown | Lung cancer, Melanoma | A375, G361, NCI-H1299, SK-MEL-28 | Yes | ||
| 3397 | ID1 | Overexpression | Dermal endothelial, Umbilical vein endothelial | Primary cell | No | ||
| 3489 | IGFBP6 | Knockdown, Overexpression | Fibroblast | Primary cell | No | ||
| 10765 | KDM5B | Knockdown | Colon cancer | Colo201, DLD1, HCT116 | Yes | ||
| 57650 | KIAA1524 | Knockdown | Gastric cancer | AGS, BGC-823, HGC-27, KATO-III | Yes | ||
| 9365 | KL | Knockdown | Lung fibroblast | MRC-5, WI-38 | No | ||
| 9113 | LATS1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 3958 | LGALS3 | Knockdown | Gastric cancer | AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2 | Yes | ||
| 4085 | MAD2L1 | Knockdown | Breast epithelial, Lung fibroblast | IMR-90, MCF-10A | No | ||
| 5606 | MAP2K3 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 11184 | MAP4K1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 54708 | MARCH5 | Knockdown | Cervical cancer | HeLa | Yes | ||
| 4190 | MDH1 | Knockdown | Dermal fibroblast, Lung fibroblast | IMR-90, Primary cell | No | ||
| 4204 | MECP2 | Knockdown | Mesenchymal stem | Primary cell | No | ||
| 4318 | MMP9 | Knockdown | Medulloblastoma | DAOY | Yes | ||
| 4638 | MYLK | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 79923 | NANOG | Overexpression | Dermal fibroblast, Fibroblast | NIH3T3, Oct4-GiP | Yes | ||
| 4750 | NEK1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 10783 | NEK6 | Overexpression | Bladder cancer, Lung cancer | EJ, NCI-H1299 | Yes | ||
| 4780 | NFE2L2 | Knockout | Lung fibroblast | HFL-1 | No | ||
| 23598 | PATZ1 | Knockdown, Overexpression | Umbilical vein endothelial | Primary cell | No | ||
| 25913 | POT1 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 5495 | PPM1B | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 8493 | PPM1D | Overexpression | Mesenchymal stem | Primary cell | No | ||
| 55170 | PRMT6 | Knockdown | Breast cancer, Breast epithelial | MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3 | Yes | ||
| 27339 | PRPF19 | Overexpression | Dermal fibroblast, Umbilical vein endothelial | Primary cell | No | ||
| 5693 | PSMB5 | Overexpression | Multipotent bone marrow stromal | Primary cell | No | ||
| 10213 | PSMD14 | Knockdown | Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer | A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75 | Yes | ||
| 5885 | RAD21 | Knockdown | Breast cancer | MDA-MB-231 | No | ||
| 5948 | RBP2 | Knockout | Cervical cancer, Gastric cancer | AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa | Yes | ||
| 9978 | RBX1 | Knockdown | Glioblastoma, Lung cancer | U87 | Yes | ||
| 26156 | RSL1D1 | Knockout, Overexpression | Lung fibroblast | 2BS | No | ||
| 10856 | RUVBL2 | Knockdown | Kidney cancer | A498, KRC/Y | Yes | ||
| 280636 | SELENOH | Knockdown | Lung fibroblast | MRC-5 | No | ||
| 29843 | SENP1 | Knockdown | Foreskin fibroblast | Primary cell | No | ||
| 59343 | SENP2 | Knockdown | Foreskin fibroblast | Primary cell | No | ||
| 57337 | SENP7 | Knockdown | Foreskin fibroblast | Primary cell | No | ||
| 6446 | SGK1 | Overexpression | Umbilical vein endothelial | Primary cell | No | ||
| 23411 | SIRT1 | Overexpression | Lung fibroblast | 2BS | No | ||
| 51548 | SIRT6 | Knockdown | Chondrocyte | NHAC-kn | No | ||
| 6495 | SIX1 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 9194 | SLC16A7 | Knockdown | Colon cancer, Gastric cancer | DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480 | Yes | ||
| 6597 | SMARCA4 | Knockdown | Mesenchymal stem | Primary cell | No | ||
| 23049 | SMG1 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 6615 | SNAI1 | Knockdown | Prostate cancer | LNCaP, PC-3 | Yes | ||
| 6647 | SOD1 | Knockdown | Lung fibroblast | WI-38, WI38-SV40 | No | ||
| 6909 | TBX2 | Knockdown | Melanoma | B16 | Yes | ||
| 7012 | TERC | Knockdown | Cervical cancer | HeLa | Yes | ||
| 7014 | TERF2 | Knockout | Neuroblastoma | SH-SY5Y | Yes | ||
| 7015 | TERT | Overexpression | Foreskin fibroblast, Retinal pigment epithelial | BJ, RPE-340 | No | ||
| 7027 | TFDP1 | Knockdown | Cervical cancer, Lung cancer, Lung fibroblast | A549, HeLa, WI-38 | Yes | ||
| 7114 | TMSB4X | Overexpression | Nucleus pulposus | Primary cell | No | ||
| 8741 | TNFSF13 | Knockdown | Colon cancer | SW480 | Yes | ||
| 7175 | TPR | Knockdown | Cervical cancer, Melanoma, Osteosarcoma | A375, HeLa, U2OS | Yes | ||
| 79054 | TRPM8 | Knockdown | Pancreatic cancer | BxPC-3, PANC-1 | Yes | ||
| 7295 | TXN | Knockdown | Foreskin fibroblast | BJ, BJE-LT | No | ||
| 7422 | VEGFA | Overexpression | Dermal endothelial | Primary cell | No | ||
| 7472 | WNT2 | Knockdown | Lung fibroblast | WI-38 | No | ||
| 11059 | WWP1 | Knockdown, Overexpression | Lung fibroblast | 2BS, WI-38 | No | ||
| 10413 | YAP1 | Knockdown | Foreskin fibroblast, Lung fibroblast | BJ, IMR-90, WI-38 | No | ||
| 64393 | ZMAT3 | Knockdown | Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma | HEK293T, MCF-7, U2OS | Yes | ||
| 7707 | ZNF148 | Knockout | Lung cancer | NCI-H460 | Yes | ||
| 51474 | LIMA1 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 4116 | MAGOH | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 55110 | MAGOHB | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 64175 | P3H1 | Knockdown | Lung fibroblast | IMR-90 | No | ||
| 9682 | KDM4A | Knockdown | Lung cancer | A549 | Yes | ||
| 283455 | KSR2 | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| 123169 | LEO1 | Overexpression | Lung fibroblast | 2BS | No | ||
| 5286 | PIK3C2A | Knockdown | Embryonic kidney, Retinal pigment epithelial | HEK293T, hTERT-RPE1 | Yes | ||
| Reference: HAGR | |||||||