Aging and Senescence

      Aging cell
Gene/product Gene/product name Annotation qualifier GO class (direct) Annotation extension Contributor Organism Evidence Evidence with PANTHER family Type Isoform Reference Date
Q32KM8 Augurin   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
c21h2orf40 Uncharacterized protein   cellular senescence   GO_Central Oryzias latipes IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
W5MQP3 Uncharacterized protein   cellular senescence   GO_Central Lepisosteus oculatus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS Uncharacterized protein   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C11H2orf40 Uncharacterized protein   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
C2orf40 Chromosome 2 open reading frame 40   cellular senescence   GO_Central Anolis carolinensis IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
Aspfo1_0209226     replicative senescence   AspGD NCBITaxon:1137211 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AFUB_060320     replicative senescence   AspGD Aspergillus fumigatus A1163 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspgl1_0177235     replicative senescence   AspGD NCBITaxon:1160497 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
budA     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus niger CBS 513.88 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
An07g07660     regulation of cell aging   AspGD Aspergillus niger CBS 513.88 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Afu2g03210     regulation of cell aging   AspGD Aspergillus fumigatus IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
ATET_02002     replicative senescence   AspGD Aspergillus terreus NIH2624 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspsy1_0143497     replicative senescence   AspGD NCBITaxon:75750 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
budA     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
AN11910     regulation of cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Afu1g09640     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus fumigatus IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
ACLA_015700     replicative senescence   AspGD Aspergillus clavatus NRRL 1 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090701001210     regulation of cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Acar5010_174030     replicative senescence   AspGD NCBITaxon:602072 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090012000904     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspve1_0212464     replicative senescence   AspGD NCBITaxon:46472 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspwe1_0058885     replicative senescence   AspGD NCBITaxon:1073089 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
tp53 tumor protein p53   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 cellular tumor antigen p53 pthr11447 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
tp53 tumor protein p53   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 cellular tumor antigen p53 pthr11447 protein_coding_gene   PMID:24967584 2E+07
ing2 inhibitor of growth family, member 2   regulation of cellular senescence   ZFIN Danio rerio IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein_coding_gene   ZFIN:ZDB-PUB-020724-1 2E+07
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-MRPHLNO-081229-2 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IMP ZFIN:ZDB-MRPHLNO-081229-2 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
romo1 reactive oxygen species modulator 1   replicative senescence   UniProt Danio rerio ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
becn1 beclin 1, autophagy related   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 beclin 1 pthr12768 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
becn1 beclin 1, autophagy related   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-MRPHLNO-081229-2 beclin 1 pthr12768 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
grnb granulin b   negative regulation of cell aging   ZFIN Danio rerio IGI ZFIN:ZDB-GENE-030131-7393 granulin pthr12274 protein_coding_gene   PMID:32028681 2E+07
march5l membrane-associated ring finger (C3HC4) 5, like   negative regulation of cell aging   UniProt Danio rerio ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
lmna lamin A   regulation of cell aging   ZFIN Danio rerio IMP ZFIN:ZDB-GENO-110523-6 lamin dm0-related pthr45721 protein_coding_gene   PMID:21479207 2E+07
ybx1 Y box binding protein 1   negative regulation of cellular senescence   UniProt Danio rerio ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
Map3k3 mitogen activated protein kinase kinase kinase 3   negative regulation of cellular senescence occurs inbone marrow cell RGD Rattus norvegicus ISO UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 gene   RGD:1624291 2E+07
ecrg4b ECRG4 augurin precursor b   cellular senescence   GO_Central Danio rerio IBA PANTHER:PTN002835855 augurin pthr31613 protein_coding_gene   PMID:21873635 2E+07
MGI:MGI:1926146
ecrg4a ECRG4 augurin precursor a   cellular senescence   GO_Central Danio rerio IBA PANTHER:PTN002835855 augurin pthr31613 protein_coding_gene   PMID:21873635 2E+07
MGI:MGI:1926146
Cdkn1a cyclin-dependent kinase inhibitor 1A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 gene   RGD:1624291 2E+07
Cdkn1a cyclin-dependent kinase inhibitor 1A   replicative senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 gene   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559 RGD:1600115
Morc3 MORC family CW-type zinc finger 3   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 gene   RGD:1624291 2E+07
Vash1 vasohibin 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 gene   RGD:1624291 2E+07
Npm1 nucleophosmin 1   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P06748 nucleoplasmin pthr22747 gene   GO_REF:0000024 2E+07
RGD:1600115
Npm1 nucleophosmin 1   cell aging   RGD Rattus norvegicus ISO UniProtKB:P06748 nucleoplasmin pthr22747 gene   RGD:1624291 2E+07
Bmpr1a bone morphogenetic protein receptor type 1A   regulation of cellular senescence regulates→occurs induct epithelial cell RGD Rattus norvegicus ISO MGI:1338938 transforming growth factor-beta receptor type i and ii pthr23255 gene   RGD:1624291 2E+07
Mir128-2 microRNA 128-2   cell aging   RGD Rattus norvegicus ISO MGI:3618709   gene   RGD:1624291 2E+07
Pml PML nuclear body scaffold   cell aging   RGD Rattus norvegicus ISO MGI:104662 bonus, isoform c-related pthr25462 gene   RGD:1624291 2E+07
Pml PML nuclear body scaffold   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P29590 bonus, isoform c-related pthr25462 gene   RGD:1624291 2E+07
Prelp proline and arginine rich end leucine rich repeat protein   cell aging   RGD Rattus norvegicus ISO MGI:2151110 agap008170-pa pthr45712 gene   RGD:1624291 2E+07
Mme membrane metallo-endopeptidase   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 gene   GO_REF:0000024 2E+07
RGD:1600115
Mme membrane metallo-endopeptidase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 gene   RGD:1624291 2E+07
Met MET proto-oncogene, receptor tyrosine kinase   cell aging   RGD Rattus norvegicus IEP   tyrosine-protein kinase receptor pthr24416 gene   PMID:18202313 2E+07
RGD:2317463
Mir15b microRNA 15b   cell aging   RGD Rattus norvegicus ISO MGI:2676842   gene   RGD:1624291 2E+07
Pawr pro-apoptotic WT1 regulator   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 gene UniProtKB:G3V6S1 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951 RGD:1600115
Pawr pro-apoptotic WT1 regulator   positive regulation of cellular senescence occurs infibroblast of cardiac tissue RGD Rattus norvegicus ISO MGI:2149961 prostate apoptosis response protein par-4 pthr15093 gene   RGD:1624291 2E+07
Mir125b1 microRNA 125b-1   cell aging   RGD Rattus norvegicus ISO MGI:2676810   gene   RGD:1624291 2E+07
Mir19b1 microRNA 19b-1   cell aging   RGD Rattus norvegicus ISO MGI:3629917   gene   RGD:1624291 2E+07
Mir34b microRNA 34b   cell aging   RGD Rattus norvegicus ISO MGI:3619364   gene   RGD:1624291 2E+07
Mir134 microRNA 134   cell aging   RGD Rattus norvegicus ISO MGI:2676819   gene   RGD:1624291 2E+07
Mir20a microRNA 20a   cell aging   RGD Rattus norvegicus ISO MGI:2676872   gene   RGD:1624291 2E+07
Tp63 tumor protein p63   cell aging occurs inEMAPA:17528 RGD Rattus norvegicus ISO MGI:1330810 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
occurs inkeratinocyte
Tp63 tumor protein p63   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9H3D4 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
UniProtKB:Q9H3D4-2
Bcl6 BCL6, transcription repressor   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:107187 zinc finger and btb domain-containing pthr24399 gene   RGD:1624291 2E+07
Mir23a microRNA 23a   cell aging   RGD Rattus norvegicus ISO MGI:2676897   gene   RGD:1624291 2E+07
Mir31 microRNA 31   cell aging   RGD Rattus norvegicus ISO MGI:3619330   gene   RGD:1624291 2E+07
Mir125a microRNA 125a   cell aging   RGD Rattus norvegicus ISO MGI:2676809   gene   RGD:1624291 2E+07
Mir130a microRNA 130a   cell aging   RGD Rattus norvegicus ISO MGI:2676816   gene   RGD:1624291 2E+07
Mir199a2 microRNA 199a-2   cell aging   RGD Rattus norvegicus ISO MGI:3618742   gene   RGD:1624291 2E+07
Mir370 microRNA 370   cell aging   RGD Rattus norvegicus ISO MGI:3619375   gene   RGD:1624291 2E+07
Mir140 microRNA 140   cell aging   RGD Rattus norvegicus ISO MGI:2676825   gene   RGD:1624291 2E+07
Mir24-2 microRNA 24-2   cell aging   RGD Rattus norvegicus ISO MGI:3618755   gene   RGD:1624291 2E+07
Mir296 microRNA 296   cell aging   RGD Rattus norvegicus ISO MGI:3619269   gene   RGD:1624291 2E+07
Nox4 NADPH oxidase 4   cell aging   UniProt Rattus norvegicus ISS UniProtKB:Q9JHI8 nadph oxidase pthr11972 gene   GO_REF:0000024 2E+07
RGD:1600115
Nox4 NADPH oxidase 4   cell aging   RGD Rattus norvegicus ISO MGI:1354184 nadph oxidase pthr11972 gene   RGD:1624291 2E+07
LOC100912427 nuclease-sensitive element-binding protein 1-like   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:99146   gene   RGD:1624291 2E+07
Serpine1 serpin family E member 1   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene   GO_REF:0000024 2E+07
RGD:1600115
Serpine1 serpin family E member 1   replicative senescence   Ensembl Rattus norvegicus IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene UniProtKB:F1LM16 GO_REF:0000107 2E+07
ensembl:ENSP00000223095 RGD:1600115
Serpine1 serpin family E member 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene   RGD:1624291 2E+07
Cdk6 cyclin-dependent kinase 6   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q00534 cell division protein kinase pthr24056 gene   RGD:1624291 2E+07
Mif macrophage migration inhibitory factor   cell aging   RGD Rattus norvegicus ISO MGI:96982 d-dopachrome decarboxylase pthr11954 gene   RGD:1624291 2E+07
Mif macrophage migration inhibitory factor   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 gene   RGD:1624291 2E+07
Wrn WRN RecQ like helicase   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q14191 dna helicase recq family member pthr13710 gene   RGD:1624291 2E+07
Wrn WRN RecQ like helicase   replicative senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:109635 dna helicase recq family member pthr13710 gene   RGD:1624291 2E+07
Mir27a microRNA 27a   cell aging   RGD Rattus norvegicus ISO MGI:2676902   gene   RGD:1624291 2E+07
Mir19b2 microRNA 19b-2   cell aging   RGD Rattus norvegicus ISO MGI:2676868   gene   RGD:1624291 2E+07
Plk2 polo-like kinase 2   negative regulation of cellular senescence occurs inadult endothelial progenitor cell RGD Rattus norvegicus ISO MGI:1099790 serine/threonine-protein kinase plk pthr24345 gene   RGD:1624291 2E+07
grna granulin a   negative regulation of cell aging   ZFIN Danio rerio IGI ZFIN:ZDB-GENE-030131-7393 granulin pthr12274 protein_coding_gene   PMID:32028681 2E+07
NAC6 NAC domain containing protein 6   stress-induced premature senescence   UniProt Arabidopsis thaliana IMP   protein cup-shaped cotyledon 2-related pthr31744 protein TAIR:locus:2164895 TAIR:Publication:501750682 2E+07
PMID:22930749
TFL1 TERMINAL FLOWER 1   negative regulation of cell aging   TAIR Arabidopsis thaliana IMP   phosphatidylethanolamine-binding protein pthr11362 protein TAIR:locus:2150595 TAIR:Publication:501732666 2E+07
PMID:18713382
ATB' GAMMA AT4G15415   regulation of cell aging   TAIR Arabidopsis thaliana IMP   serine/threonine protein phosphatase 2a pp2a regulatory subunit b pthr10257 protein TAIR:locus:505006470 TAIR:Publication:501742604 2E+07
PMID:21571669
GBF1 G-box binding factor 1   regulation of cell aging   TAIR Arabidopsis thaliana IMP   g-box-binding factor 3-related pthr45967 protein TAIR:locus:2115250 TAIR:Publication:501737893 2E+07
PMID:20484024
Abi3bp ABI family member 3 binding protein   positive regulation of cellular senescence part ofdefense response to tumor cell ARUK-UCL Rattus norvegicus ISS UniProtKB:Q9P2A4 tarsh-related fibronectin domain-containing pthr23197 gene   GO_REF:0000024 2E+07
RGD:1600115
MTOR Serine/threonine-protein kinase mTOR   cell aging   Ensembl Homo sapiens IEA UniProtKB:P42346 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000014167
ECRG4 Augurin   cellular senescence   GO_Central Homo sapiens IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
SLC30A10 Zinc transporter 10   negative regulation of cellular senescence   UniProt Homo sapiens IDA   fi23527p1 pthr45820 protein   PMID:22427991 2E+07
MAPK14 Mitogen-activated protein kinase 14   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
MAPK14 Mitogen-activated protein kinase 14   stress-induced premature senescence   BHF-UCL Homo sapiens IMP   mitogen-activated protein kinase pthr24055 protein   PMID:20160708 2E+07
CDKN2B Cyclin-dependent kinase 4 inhibitor B   cellular senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:17553787 2E+07
Cyclin-dependent kinase inhibitor 2A   cellular senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:16243918 2E+07  
CDKN2A Cyclin-dependent kinase inhibitor 2A   replicative senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:14720514 2E+07
CDKN2A Cyclin-dependent kinase inhibitor 2A   positive regulation of cellular senescence   UniProt Homo sapiens IMP   family not named pthr24201 protein   PMID:16901784 2E+07
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Homo sapiens IMP   uncharacterized pthr21330 protein   PMID:17589526 2E+07
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
OPA1 Dynamin-like 120 kDa protein, mitochondrial   cellular senescence   UniProt Homo sapiens IDA   dynamin pthr11566 protein   PMID:17545159 2E+07
FOXM1 Forkhead box protein M1   negative regulation of cell aging   UniProt Homo sapiens IMP   forkhead box protein m1 pthr46878 protein   PMID:19696738 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Homo sapiens IMP   superoxide dismutase cu-zn -related pthr10003 protein   PMID:12871978 2E+07
DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99M87 dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053842
FZR1 Fizzy-related protein homolog   negative regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
PRMT6 Protein arginine N-methyltransferase 6   cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000140836
ICAM1 Intercellular adhesion molecule 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q00238 intercellular adhesion molecule pthr13771 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000028066
NUAK1 NUAK family SNF1-like kinase 1   regulation of cellular senescence   UniProt Homo sapiens IDA   serine/threonine kinase pthr24343 protein   PMID:19927127 2E+07
SPI1 Transcription factor PU.1   oncogene-induced cell senescence occurs infibroblast ARUK-UCL Homo sapiens ISS UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000024 2E+07
occurs inhematopoietic stem cellmore...
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Homo sapiens IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
ZMPSTE24 CAAX prenyl protease 1 homolog   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   cell aging   BHF-UCL Homo sapiens TAS   histone deacetylase sir2 family member pthr11085 protein   PMID:11672523 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   stress-induced premature senescence   CACAO Homo sapiens IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:17916362 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   negative regulation of cellular senescence   UniProt Homo sapiens IDA   histone deacetylase sir2 family member pthr11085 protein   PMID:20203304 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:20424141 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   positive regulation of cellular senescence   UniProt Homo sapiens IDA   histone deacetylase sir2 family member pthr11085 protein   PMID:18687677 2E+07
EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1   positive regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA   eukaryotic translation elongation factor 1 epsilon-1 pthr44490 protein   PMID:25465621 2E+07
ATM Serine-protein kinase ATM   cellular senescence   Reactome Homo sapiens TAS   ataxia telangiectasia mutated atm -related pthr11139 protein   Reactome:R-HSA-2559583 2E+07
ATM Serine-protein kinase ATM   replicative senescence   BHF-UCL Homo sapiens IMP   ataxia telangiectasia mutated atm -related pthr11139 protein   PMID:15149599 2E+07
NUP62 Nuclear pore glycoprotein p62   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
TP63 Tumor protein 63   cell aging   Ensembl Homo sapiens IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
ZMIZ1 Zinc finger MIZ domain-containing protein 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
ABI3 ABI gene family member 3   positive regulation of cellular senescence part ofdefense response to tumor cell ARUK-UCL Homo sapiens IMP   abl interactor family member pthr10460 protein   PMID:21223585 2E+07
HMGA2 High mobility group protein HMGI-C   oncogene-induced cell senescence   UniProt Homo sapiens IDA   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
HMGA2 High mobility group protein HMGI-C   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens ISS UniProtKB:P52927 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA2 High mobility group protein HMGI-C   positive regulation of cellular senescence   UniProt Homo sapiens IMP   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
CALR Calreticulin   cellular senescence   BHF-UCL Homo sapiens IGI ENSEMBL_GeneID:ENSG00000124762 calreticulin and calnexin pthr11073 protein   PMID:14726956 2E+07
ING2 Inhibitor of growth protein 2   regulation of cellular senescence   BHF-UCL Homo sapiens NAS   inhibitor of growth protein pthr10333 protein   PMID:21124965 2E+07
PAWR PRKC apoptosis WT1 regulator protein   positive regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Homo sapiens IMP   mannose, phospholipase, lectin receptor related pthr22803 protein   PMID:19197340 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Homo sapiens IMP   mannose, phospholipase, lectin receptor related pthr22803 protein   PMID:19197340 2E+07
ABL1 Tyrosine-protein kinase ABL1   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
SMC6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Homo sapiens IMP   structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   PMID:17589526 2E+07
TBX2 T-box transcription factor TBX2   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11748239 2E+07
TBX2 T-box transcription factor TBX2   cellular senescence   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:22002537 2E+07
ULK3 Serine/threonine-protein kinase ULK3   cellular senescence   UniProt Homo sapiens TAS   serine/threonine-protein kinase unc-51-related pthr24348 protein   PMID:19279323 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Homo sapiens IMP   serine protease inhibitor, serpin pthr11461 protein   PMID:16862142 2E+07
  Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:22002537 2E+07
PML Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:22117195 2E+07
PML Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:23431171 2E+07
WNT16 Protein Wnt-16   replicative senescence   BHF-UCL Homo sapiens IMP   wnt related pthr12027 protein   PMID:19951988 2E+07
WNT16 Protein Wnt-16   oxidative stress-induced premature senescence   BHF-UCL Homo sapiens IMP   wnt related pthr12027 protein   PMID:19951988 2E+07
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9Y243   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MME Atriopeptidase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P08473   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence occurs inaortic endothelial cell AgBase Sus scrofa IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:20203304 2E+07
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
PRELP LRRNT domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
MIF Macrophage migration inhibitory factor   cell aging   Ensembl Sus scrofa IEA UniProtKB:P34884 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000041149
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000215754
LMNA Lamin isoform A   positive regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P02545   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
P14ARF ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
P14ARF ANK_REP_REGION domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
P14ARF ANK_REP_REGION domain-containing protein   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase dsor1-like protein pthr47448 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Sus scrofa IEA UniProtKB:O88898   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   Ensembl Sus scrofa IEA UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
MNT BHLH domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q8IW41   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
CDKN2B ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42772 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000276925
MARCHF5 Membrane associated ring-CH-type finger 5   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P51957   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
BCL2L12 BCL2 like 12   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9D3J3 family not named pthr14965 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003290
CALR Calreticulin   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
WRN DNA helicase   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q14191 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000298139
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Sus scrofa ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
FBXO5 F-box domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
CDKN1A CDI domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000244741
CDKN1A CDI domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
RSL1D1 Ribosomal L1 domain containing 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O76021   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
STK11 Non-specific serine/threonine protein kinase   positive regulation of cellular senescence occurs inaortic endothelial cell AgBase Sus scrofa IMP   family not named pthr43895 protein   PMID:20203304 2E+07
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P60602   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
TERF2 HTH myb-type domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
SPI1 ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Sus scrofa IEA UniProtKB:P17433   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000002180
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q08050   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P28749   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
BCL6 B-cell CLL/lymphoma 6   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
PAWR Pro-apoptotic WT1 regulator   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
TP53 Cellular tumor antigen p53   cell aging   UniProt Sus scrofa ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
PRMT6 Methyltransf_25 domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000140836
Inhibitor of growth protein   regulation of cellular senescence   InterPro Sus scrofa IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07  
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:E9Q6D6   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q53EL6   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
SERPINE1 SERPIN domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000223095
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q13018   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q13018   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
NUP62 Nsp1_C domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
PRKCD Protein kinase C   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q05655   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O60313   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
YPEL3 Protein yippee-like   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P61236   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
WNT16 Protein Wnt   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
PML PML nuclear body scaffold   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
NPM1 Nucleophosmin   cell aging   Ensembl Sus scrofa IEA UniProtKB:P06748   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000296930
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P78540 arginase pthr43782 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
HLA-G HLA class I histocompatibility antigen, alpha chain G   positive regulation of cellular senescence   UniProt Homo sapiens IDA   mhc class i-related pthr16675 protein   PMID:23184984 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Homo sapiens IDA   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Homo sapiens IMP   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
URS000075AC88_9823 Sus scrofa (pig) microRNA ssc-mir-342 precursor   cell aging   RNAcentral Sus scrofa IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000A95B56_9823 Sus scrofa (pig) microRNA ssc-mir-370 precursor   cell aging   RNAcentral Sus scrofa IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Sus scrofa ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000024 2E+07
MAPK14 Mitogen-activated protein kinase 14   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q16539   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229794
URS000071B780_9606 Homo sapiens (human) microRNA hsa-mir-342 precursor   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000EFD26A_9606 Homo sapiens (human) Hsa-Mir-342 stem-loop   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000039ED8D_9606 Homo sapiens (human) hsa-miR-21-5p   positive regulation of replicative senescence regulates→occurs inendothelial cell BHF-UCL Homo sapiens IDA     miRNA   PMID:23496142 2E+07
URS0000272039_9606 Homo sapiens (human) hsa-miR-590-3p   negative regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25465621 2E+07
URS00007281EA_9606 Homo sapiens microRNA mir-370   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS000030BD69_9606 Homo sapiens (human) hsa-miR-34a-5p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IDA     miRNA   PMID:20424141 2E+07
URS000019F055_9606 Homo sapiens (human) hsa-miR-543   negative regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25465621 2E+07
URS000041E210_9606 Homo sapiens (human) hsa-miR-217-5p   positive regulation of cellular senescence occurs inblood vessel endothelial cell BHF-UCL Homo sapiens IMP     miRNA   PMID:19786632 2E+07
URS000075B235_9606 Homo sapiens (human) microRNA hsa-mir-370 precursor   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS00004416C5_9606 Homo sapiens (human) telomerase RNA component   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     telomerase_RNA   PMID:11313459 2E+07
URS00002B3783_9606 Homo sapiens (human) hsa-miR-20b-5p   positive regulation of cellular senescence occurs inmicrovascular endothelial cell BHF-UCL Homo sapiens IMP     miRNA   PMID:28595801 2E+07
URS000050B527_9606 Homo sapiens (human) hsa-miR-146a-5p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens ISS RNAcentral:URS000050B527_10090   miRNA   GO_REF:0000024 2E+07
URS0000EFE467_9606 Homo sapiens (human) Hsa-Mir-370 stem-loop   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS0000083D87_9606 Homo sapiens (human) hsa-miR-188-5p   positive regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens IDA     miRNA   PMID:28640956 2E+07
tert-terc_human Telomerase catalytic core complex   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     protein_complex   PMID:11313459 2E+07
abeta-42-oligomer_human Amyloid-beta protein 42 oligomeric complex   positive regulation of cellular senescence regulates→occurs inmicroglial cell ARUK-UCL Homo sapiens IDA     protein_complex   PMID:28912710 2E+07
URS0000096022_9606 Homo sapiens (human) hsa-miR-22-3p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25323119 2E+07
URS00004A7003_9606 Homo sapiens telomerase RNA component (TERC)   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     telomerase_RNA   PMID:11313459 2E+07
AKT3 RAC-gamma serine/threonine-protein kinase   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IMP   serine/threonine-protein kinase pthr24356 protein   PMID:25323119 2E+07
FBXO5 F-box only protein 5   negative regulation of cellular senescence   UniProt Homo sapiens IMP   f-box only protein 5 and 43 pthr15493 protein   PMID:17875940 2E+07
MORC3 CW-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q14149   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
YBX1 CSD domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P62960   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589
PLA2R1 Uncharacterized protein   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
PLA2R1 Uncharacterized protein   oxidative stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
B2M Beta-2-microglobulin   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P61769 mhc class ii-related pthr19944 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000497910
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
MIF Macrophage migration inhibitory factor   cell aging   Ensembl Gallus gallus IEA UniProtKB:P34884 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000041149
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000215754
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
PAWR Uncharacterized protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
HRAS GTPase HRas   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309845
SLC30A10 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355893
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
BCL6 B-cell lymphoma 6 protein homolog   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P41183 ip01015p-related pthr24377 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P78540 arginase pthr43782 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
MME Atriopeptidase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Gallus gallus IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
SPI1 ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Gallus gallus IEA UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000002180
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
cdk6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Gallus gallus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
MAPK14 Mitogen-activated protein kinase   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229794
MAP3K3 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
HMGA1 High mobility group A1b   oncogene-induced cell senescence   UniProt Gallus gallus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA1 High mobility group A1b   positive regulation of cellular senescence   UniProt Gallus gallus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Gallus gallus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
ABI3 Abi_HHR domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
DNAJA3 Uncharacterized protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q99M87 dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053842
5-Mar RING-CH-type domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
VASH1 Uncharacterized protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9Y243 ribosomal protein s6 kinase pthr24351 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MORC4 CW-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96MF7 uncharacterized pthr21330 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Gallus gallus ISS UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   GO_REF:0000024 2E+07
LOC396224 IF rod domain-containing protein   positive regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P02545 lamin dm0-related pthr45721 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
ZNF277 C2H2-type domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
WNT16 Protein Wnt   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
TBX domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O15119   protein   GO_REF:0000107 2E+07  
ensembl:ENSP00000257567  
RWDD1 RWD domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9CQK7 rwd domain-containing protein pthr12292 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000019917
HMGI-C High mobility group protein I-C   oncogene-induced cell senescence   Ensembl Gallus gallus IEA UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000384026
HMGI-C High mobility group protein I-C   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000384026
MB21D1 Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Gallus gallus IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Gallus gallus ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000024 2E+07
RBL1 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
B9J08_002050     regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
ERCC1 DNA excision repair protein ERCC-1   replicative senescence   Ensembl Bos taurus IEA UniProtKB:P07903 excision repair cross-complementing 1 ercc1 pthr12749 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003645
HMGA2 High mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Bos taurus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA2 High mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Bos taurus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
TP53 Cellular tumor antigen p53   cell aging   UniProt Bos taurus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   Ensembl Bos taurus IEA UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
BCL6 BCL6 transcription repressor   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Bos taurus ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Bos taurus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Bos taurus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
CDKN1A CDI domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000244741
CDKN1A CDI domain-containing protein   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
BCL2L12 BCL2 like 12   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9D3J3 family not named pthr14965 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003290
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Bos taurus IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Bos taurus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Bos taurus ISS UniProtKB:Q96MF7 uncharacterized pthr21330 protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Bos taurus ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P78540   protein   GO_REF:0000107 2E+07
 
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
BRCA2 Tower domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
TWIST1 BHLH domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000242261
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
CGAS Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q5SUQ9 cst complex subunit ctc1 pthr14865 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
PRELP LRRNT domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9JK53 ig(immunoglobulin) and lrr(leucine rich repeat) domains pthr24366 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
ROMO1 Reactive oxygen species modulator 1   replicative senescence   UniProt Bos taurus ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Bos taurus ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000024 2E+07
TERF2 HTH myb-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
PML PML nuclear body scaffold   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
PAWR Uncharacterized protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
ZMPSTE24 CAAX prenyl protease   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
NUP62 Nsp1_C domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Bos taurus IEA UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
WNT16 Protein Wnt   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
LMNA Lamin A/C   positive regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P02545 lamin dm0-related pthr45721 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
YPEL3 Protein yippee-like   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
SLC30A10 Solute carrier family 30 member 10   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355893
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Bos taurus ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000024 2E+07
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Bos taurus IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Bos taurus IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
ABI3 SH3 domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354957
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
CALR Calreticulin   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PRELP LRRNT domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
CDKN2B ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P42772 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000276925
SOD1 Sod_Cu domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
CALR Calreticulin   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P14211   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P27797   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Canis lupus familiaris ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Canis lupus familiaris ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q5SUQ9   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000107 2E+07  
ensembl:ENSMUSP00000002180  
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
ensembl:ENSP00000354927
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q7L8A9   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P60602   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O14746   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O14746   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q02750   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
MARCHF5 RING-CH-type domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
BCL6 B-cell lymphoma 6 protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P41183   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
PLK2 Polo kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P53351   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
WRN DNA helicase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
MORC3 CW-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000024 2E+07
MNT BHLH domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
URS0000EFF4B3_9913 Bos taurus (cattle) Bta-Mir-342 stem-loop   cell aging   RNAcentral Bos taurus IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000075E3EC_9913 Bos taurus (cattle) microRNA bta-mir-370 precursor   cell aging   RNAcentral Bos taurus IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS000075C963_9913 Bos taurus (cattle) microRNA bta-mir-342 precursor   cell aging   RNAcentral Bos taurus IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000EFBD9D_9913 Bos taurus (cattle) Bta-Mir-370 stem-loop   cell aging   RNAcentral Bos taurus IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
WRN DNA helicase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
TWIST1 BHLH domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000242261
NPM1 Nucleophosmin   cell aging   UniProt Gallus gallus ISS UniProtKB:P06748 nucleoplasmin pthr22747 protein   GO_REF:0000024 2E+07
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   AgBase Gallus gallus ISA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   PMID:16307863 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   Ensembl Gallus gallus IEA UniProtKB:P00441   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
CALR Calreticulin   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P11831   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
RSL1D1 Uncharacterized protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
C1H2ORF40 Uncharacterized protein   cellular senescence   GO_Central Gallus gallus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
TBX3 T-box transcription factor TBX3   cell aging   UniProt Gallus gallus ISS UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000024 2E+07
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   MGI Mus musculus ISO UniProtKB:O60313 dynamin pthr11566 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Foxm1 forkhead box M1   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pla2r1 phospholipase A2 receptor 1   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Morc3 microrchidia 3   cell aging   MGI Mus musculus ISO UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   MGI:MGI:3763815 2E+07
PMID:17332504
Trp63 transformation related protein 63   cell aging occurs inEMAPA:17528 MGI Mus musculus IMP MGI:MGI:2385473 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:3588617 2E+07
occurs inkeratinocyte PMID:16107615
Trp63 transformation related protein 63   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9H3D4 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Arg2 arginase type II   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P78540 arginase pthr43782 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zfp217 zinc finger protein 217   cell aging   MGI Mus musculus ISO EMBL:AF041259 zinc finger protein pthr45925 protein   MGI:MGI:2154458 2E+07
GO_REF:0000008
Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2183945 excision repair cross-complementing 1 ercc1 pthr12749 protein   MGI:MGI:893240 2E+07
PMID:9197240
Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2183944 excision repair cross-complementing 1 ercc1 pthr12749 protein   MGI:MGI:3699021 2E+07
PMID:17173483
Sod1 superoxide dismutase 1, soluble   cell aging   MGI Mus musculus ISO UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Id2 inhibitor of DNA binding 2   cellular senescence   UniProt Mus musculus IMP   dna-binding protein inhibitor pthr11723 protein   MGI:MGI:4412240 2E+07
PMID:18474814
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   MGI Mus musculus ISO UniProtKB:Q96MF7 uncharacterized pthr21330 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hras Harvey rat sarcoma virus oncogene   cell aging   MGI Mus musculus IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:2670239 2E+07
PMID:12878730
Hras Harvey rat sarcoma virus oncogene   cell aging   MGI Mus musculus IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Hras Harvey rat sarcoma virus oncogene   cellular senescence   MGI Mus musculus ISO UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hras Harvey rat sarcoma virus oncogene   cellular senescence   GO_Central Mus musculus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
Prmt6 protein arginine N-methyltransferase 6   cellular senescence   MGI Mus musculus IMP   protein arginine n-methyltransferase pthr11006 protein   MGI:MGI:5504576 2E+07
PMID:22904064
Prkdc protein kinase, DNA activated, catalytic polypeptide   negative regulation of cellular senescence   MGI Mus musculus ISO RGD:1308982 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cell aging   MGI Mus musculus IDA     protein   MGI:MGI:2159048 2E+07
PMID:11748239
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence occurs inosteoblast MGI Mus musculus IDA     protein   MGI:MGI:5449665 2E+07
occurs inosteoblast PMID:22729085
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus ISO UniProtKB:Q8N726   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus IMP     protein   MGI:MGI:5299398 2E+07
PMID:21911473
Cdkn2a cyclin dependent kinase inhibitor 2A   replicative senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2b cyclin dependent kinase inhibitor 2B   cellular senescence   MGI Mus musculus ISO UniProtKB:P42772 family not named pthr24201 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pml promyelocytic leukemia   cell aging   UniProt Mus musculus IMP   bonus, isoform c-related pthr25462 protein   MGI:MGI:3717518 2E+07
PMID:10910364
Pml promyelocytic leukemia   cellular senescence   MGI Mus musculus ISO UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Kras Kirsten rat sarcoma viral oncogene homolog   positive regulation of cellular senescence   MGI Mus musculus ISO RGD:2981 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Xrn1 5'-3' exoribonuclease 1   cell aging   UniProt Mus musculus NAS   5'->3' exoribonuclease pthr12341 protein   MGI:MGI:893338 2E+07
PMID:9218715
Ecrg4 ECRG4 augurin precursor   cellular senescence   MGI Mus musculus IDA   augurin pthr31613 protein   MGI:MGI:4454240 2E+07
PMID:20404145
Ecrg4 ECRG4 augurin precursor   cellular senescence   GO_Central Mus musculus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
Atr ataxia telangiectasia and Rad3 related   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Smc5 structural maintenance of chromosomes 5   cellular senescence   MGI Mus musculus ISO UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor)   cell aging   MGI Mus musculus IMP MGI:MGI:2673280 d-dopachrome decarboxylase pthr11954 protein   MGI:MGI:2670239 2E+07
PMID:12878730
Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor)   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1888594 caax prenyl protease 1 pthr10120 protein   MGI:MGI:5500993 2E+07
PMID:23686339
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2180033 caax prenyl protease 1 pthr10120 protein   MGI:MGI:3789238 2E+07
PMID:16079796
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2180033 caax prenyl protease 1 pthr10120 protein   MGI:MGI:5139938 2E+07
PMID:21746928
Ing2 inhibitor of growth family, member 2   regulation of cellular senescence   UniProt Mus musculus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   MGI:MGI:2152098 2E+07
GO_REF:0000002
Fzr1 fizzy and cell division cycle 20 related 1   negative regulation of cell aging   BHF-UCL Mus musculus IMP   cell division cycle 20 cdc20 fizzy -related pthr19918 protein   MGI:MGI:5009768 2E+07
PMID:21241890
Prelp proline arginine-rich end leucine-rich repeat   cell aging   MGI Mus musculus IDA   agap008170-pa pthr45712 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Mir378a microRNA 378a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21)   cellular senescence   MGI Mus musculus ISO UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tp53 tumor protein p53   cell aging   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   GO_REF:0000024 2E+07
RGD:1600115
Tp53 tumor protein p53   cell aging   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   positive regulation of cell aging   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Pla2r1 phospholipase A2 receptor 1   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   GO_REF:0000024 2E+07
RGD:1600115
Pla2r1 phospholipase A2 receptor 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   RGD:1624291 2E+07
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Rattus norvegicus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   GO_REF:0000024 2E+07
RGD:1600115
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   RGD:1624291 2E+07
Nup62 nucleoporin 62   cell aging   RGD Rattus norvegicus ISO MGI:1351500 nuclear pore glycoprotein p62-related pthr12084 gene   RGD:1624291 2E+07
Mapkapk5 MAPK activated protein kinase 5   stress-induced premature senescence   RGD Rattus norvegicus ISO MGI:1333110 serine/threonine-protein kinase pthr24349 gene   RGD:1624291 2E+07
Mapkapk5 MAPK activated protein kinase 5   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 gene   RGD:1624291 2E+07
Mir483 microRNA 483   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
microRNA 5100   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07  
PMID:25751060  
H2ax H2A.X variant histone   cellular senescence   RGD Rattus norvegicus IEP   histone h2a pthr23430 gene   PMID:19946210 2E+07
RGD:8693719
Nuak1 NUAK family kinase 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O60285 serine/threonine kinase pthr24343 gene   RGD:1624291 2E+07
Kat6a lysine acetyltransferase 6A   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q92794 histone acetyltransferase pthr10615 gene   GO_REF:0000024 2E+07
RGD:1600115
Kat6a lysine acetyltransferase 6A   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 gene UniProtKB:A0A0A0MY12 GO_REF:0000107 2E+07
ensembl:ENSP00000265713 RGD:1600115
Kat6a lysine acetyltransferase 6A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q92794 histone acetyltransferase pthr10615 gene   RGD:1624291 2E+07
Cgas cyclic GMP-AMP synthase   positive regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:2442261   gene   RGD:1624291 2E+07
Prmt6 protein arginine methyltransferase 6   cellular senescence   RGD Rattus norvegicus ISO MGI:2139971 protein arginine n-methyltransferase pthr11006 gene   RGD:1624291 2E+07
Mirlet7d microRNA let-7d   cell aging   RGD Rattus norvegicus ISO MGI:2676796   gene   RGD:1624291 2E+07
Mir342 microRNA 342   cell aging   RGD Rattus norvegicus ISO MGI:3619358   gene   RGD:1624291 2E+07
Mirlet7b microRNA let-7b   cell aging   RGD Rattus norvegicus ISO MGI:2676794   gene   RGD:1624291 2E+07
Mirlet7f2 microRNA let-7f-2   cell aging   RGD Rattus norvegicus ISO MGI:2676799   gene   RGD:1624291 2E+07
Mirlet7i microRNA let-7i   cell aging   RGD Rattus norvegicus ISO MGI:2676802   gene   RGD:1624291 2E+07
Ypel3 yippee-like 3   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 gene   RGD:1624291 2E+07
Mir22 microRNA 22   cell aging   RGD Rattus norvegicus ISO MGI:2676896   gene   RGD:1624291 2E+07
Mir23b microRNA 23b   cell aging   RGD Rattus norvegicus ISO MGI:2676898   gene   RGD:1624291 2E+07
Mir25 microRNA 25   cell aging   RGD Rattus norvegicus ISO MGI:3619266   gene   RGD:1624291 2E+07
Mir30a microRNA 30a   cell aging   RGD Rattus norvegicus ISO MGI:2676907   gene   RGD:1624291 2E+07
Mir34c microRNA 34c   cell aging   RGD Rattus norvegicus ISO MGI:3619365   gene   RGD:1624291 2E+07
Mir34a microRNA 34a   cell aging   RGD Rattus norvegicus ISO MGI:3619363   gene   RGD:1624291 2E+07
Mir99a microRNA 99a   cell aging   RGD Rattus norvegicus ISO MGI:2676912   gene   RGD:1624291 2E+07
Mir125b2 microRNA 125b-2   cell aging   RGD Rattus norvegicus ISO MGI:3618706   gene   RGD:1624291 2E+07
Mir128-1 microRNA 128-1   cell aging   RGD Rattus norvegicus ISO MGI:2676813   gene   RGD:1624291 2E+07
Mir132 microRNA 132   cell aging   RGD Rattus norvegicus ISO MGI:2676817   gene   RGD:1624291 2E+07
Rbl1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Slc30a10 solute carrier family 30, member 10   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zfp277 zinc finger protein 277   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:5496522 zinc finger protein 277 pthr13267 protein   MGI:MGI:5496352 2E+07
PMID:20808772
Lmna lamin A   positive regulation of cell aging   MGI Mus musculus ISO UniProtKB:P02545 lamin dm0-related pthr45721 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pnpt1 polyribonucleotide nucleotidyltransferase 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zmiz1 zinc finger, MIZ-type containing 1   cell aging   MGI Mus musculus IDA   zinc finger miz domain-containing protein pthr10782 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Sirt1 sirtuin 1   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Sirt1 sirtuin 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Sirt1 sirtuin 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Atm ataxia telangiectasia mutated   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13315 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Bcl6 B cell leukemia/lymphoma 6   negative regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2158436 zinc finger and btb domain-containing pthr24399 protein   MGI:MGI:5469797 2E+07
PMID:23209284
Htt huntingtin   cell aging   MGI Mus musculus IMP MGI:MGI:3603606 huntington disease protein pthr10170 protein   MGI:MGI:3619488 2E+07
PMID:16403806
Marchf5 membrane associated ring-CH-type finger 5   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Nek4 NIMA (never in mitosis gene a)-related expressed kinase 4   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1b high mobility group AT-hook 1B   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P17096   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1b high mobility group AT-hook 1B   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P17096   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Nup62 nucleoporin 62   cell aging   MGI Mus musculus IDA   nuclear pore glycoprotein p62-related pthr12084 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Ybx1 Y box protein 1   negative regulation of cellular senescence   UniProt Mus musculus IMP   cold shock domain containing proteins pthr11544 protein   MGI:MGI:6158172 2E+07
PMID:29712925
Nox4 NADPH oxidase 4   cell aging   UniProt Mus musculus IMP   nadph oxidase pthr11972 protein   MGI:MGI:3694159 2E+07
PMID:10869423
Bmpr1a bone morphogenetic protein receptor, type 1A   regulation of cellular senescence regulates→occurs induct epithelial cell MGI Mus musculus IGI MGI:MGI:87859 transforming growth factor-beta receptor type i and ii pthr23255 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Bcl2l12 BCL2-like 12 (proline rich)   negative regulation of cellular senescence   MGI Mus musculus IDA   family not named pthr14965 protein   MGI:MGI:4834958 2E+07
PMID:20837658
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Pongo abelii ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Pongo abelii ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Oryctolagus cuniculus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Delphinapterus leucas ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Cricetulus griseus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Neprilysin   replicative senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PLA2R1 Uncharacterized protein   replicative senescence   UniProt Nomascus leucogenys ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Uncharacterized protein   oxidative stress-induced premature senescence   UniProt Nomascus leucogenys ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
marchf5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Xenopus laevis ISS UniProtKB:Q9NX47   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca fuscata fuscata ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Callithrix jacchus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Equus caballus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Equus caballus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
P89002 Cellular tumor antigen p53   cell aging   UniProt Mastomys natalensis ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Equus caballus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Equus caballus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
PLA2R1 C-type lectin domain-containing protein   replicative senescence   UniProt Macaca mulatta ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 C-type lectin domain-containing protein   oxidative stress-induced premature senescence   UniProt Macaca mulatta ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Loxodonta africana ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
URS00004636A3_9606 Homo sapiens (human) hsa-miR-17-3p   negative regulation of cellular senescence occurs infibroblast of cardiac tissue BHF-UCL Homo sapiens ISS RNAcentral:URS00001D3129_10090   miRNA   GO_REF:0000024 2E+07
occurs inembryonic fibroblast
URS00002F4762_9606 Homo sapiens (human) hsa-miR-10a-3p   positive regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens ISS RNAcentral:URS00002F4762_10090   miRNA   GO_REF:0000024 2E+07
URS0000EFBA16_9615 Canis lupus familiaris (dog) Cfa-Mir-342 stem-loop   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
MNT BHLH domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
Mir183 microRNA 183   cell aging   RGD Rattus norvegicus ISO MGI:2676847   gene   RGD:1624291 2E+07
Top2b DNA topoisomerase II beta   cell aging   RGD Rattus norvegicus IDA     gene   PMID:20708677 2E+07
RGD:13432149
Mir191 microRNA 191   cell aging   RGD Rattus norvegicus ISO MGI:2676855   gene   RGD:1624291 2E+07
Mir211 microRNA 211   cell aging   RGD Rattus norvegicus ISO MGI:2676887   gene   RGD:1624291 2E+07
Tert telomerase reverse transcriptase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 gene   RGD:1624291 2E+07
Tert telomerase reverse transcriptase   negative regulation of cellular senescence occurs invascular associated smooth muscle cell RGD Rattus norvegicus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 gene   RGD:1624291 2E+07
part ofcellular response to hypoxia
Mapk14 mitogen activated protein kinase 14   stress-induced premature senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 gene UniProtKB:Q56A33 GO_REF:0000107 2E+07
ensembl:ENSP00000229794 RGD:1600115
Mapk14 mitogen activated protein kinase 14   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 gene   RGD:1624291 2E+07
Mir877 microRNA 877   cell aging   RGD Rattus norvegicus ISO MGI:3718567   gene   RGD:1624291 2E+07
Mir188 microRNA 188   cell aging   RGD Rattus norvegicus ISO MGI:2676852   gene   RGD:1624291 2E+07
Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:87859 tyrosine-protein kinase pthr24418 gene   RGD:1624291 2E+07
Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase   negative regulation of cellular senescence regulates→occurs inosteoblast RGD Rattus norvegicus ISO MGI:87859 tyrosine-protein kinase pthr24418 gene   RGD:1624291 2E+07
Srf serum response factor   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P11831 serum response factor homolog pthr48019 gene   RGD:1624291 2E+07
Mir671 microRNA 671   cell aging   RGD Rattus norvegicus ISO MGI:3629656   gene   RGD:1624291 2E+07
Fbxo5 F-box protein 5   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 gene   RGD:1624291 2E+07
Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10   cell aging   RGD Rattus norvegicus IEP   short-chain dehydrogenase/reductase pthr43658 gene   PMID:12810569 2E+07
RGD:2302236
Pnpt1 polyribonucleotide nucleotidyltransferase 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 gene   RGD:1624291 2E+07
Nuak1 NUAK family, SNF1-like kinase, 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O60285 serine/threonine kinase pthr24343 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir1897 microRNA 1897   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
ILK Integrin-linked protein kinase   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99J82 serine/threonine-protein kinase tnni3k-related pthr44329 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000025906
YPEL3 Protein yippee-like 3   positive regulation of cellular senescence   HGNC Homo sapiens IDA   protein yippee-like cg15309-related pthr13848 protein   PMID:20388804 2E+07
BRCA2 Breast cancer type 2 susceptibility protein   cell aging   Ensembl Homo sapiens IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
H2AX Histone H2AX   cellular senescence   Ensembl Homo sapiens IEA UniProtKB:D3ZXP3 histone h2a pthr23430 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000056469
B2M Beta-2-microglobulin   positive regulation of cellular senescence regulates→occurs inepithelial cell of lung ARUK-UCL Homo sapiens IDA   mhc class ii-related pthr19944 protein   PMID:28213472 2E+07
part ofcellular response to nicotine
PRKDC DNA-dependent protein kinase catalytic subunit   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:D3ZTN0 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000037412
CDK2 Cyclin-dependent kinase 2   cellular senescence   Reactome Homo sapiens TAS   cell division protein kinase pthr24056 protein   Reactome:R-HSA-2559583 2E+07
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:Q5SUQ9 cst complex subunit ctc1 pthr14865 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
TP53 Cellular tumor antigen p53   cell aging   UniProt Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:12080348 2E+07
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   BHF-UCL Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:19951988 2E+07
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   BHF-UCL Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:19951988 2E+07
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
WNT1 Proto-oncogene Wnt-1   negative regulation of cell aging   BHF-UCL Homo sapiens IDA   wnt related pthr12027 protein   PMID:16501043 2E+07
CDKN1B Cyclin-dependent kinase inhibitor 1B   cellular senescence   Reactome Homo sapiens TAS   cyclin-dependent kinase inhibitor 1 pthr10265 protein   Reactome:R-HSA-2559583 2E+07
CHEK2 Serine/threonine-protein kinase Chk2   replicative senescence   BHF-UCL Homo sapiens NAS   ovarian-specific serine/threonine-protein kinase lok-related pthr44167 protein   PMID:15149599 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Homo sapiens ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Homo sapiens IMP   structural maintenance of chromosomes protein 5 pthr45916 protein   PMID:17589526 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   BHF-UCL Homo sapiens IMP   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:15149599 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   BHF-UCL Homo sapiens IMP   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:17553787 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   Reactome Homo sapiens TAS   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   Reactome:R-HSA-2559583 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
CDKN1A Cyclin-dependent kinase inhibitor 1   stress-induced premature senescence   BHF-UCL Homo sapiens TAS   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:20160708 2E+07
LIMS1 LIM and senescent cell antigen-like-containing domain protein 1   cell aging   PINC Homo sapiens TAS   lim domain-containing protein pthr24210 protein   PMID:7517666 2E+07
ARG2 Arginase-2, mitochondrial   positive regulation of cellular senescence   UniProt Homo sapiens IDA   arginase pthr43782 protein   PMID:22928666 2E+07
MAPKAPK5 MAP kinase-activated protein kinase 5   cellular senescence   Reactome Homo sapiens TAS   serine/threonine-protein kinase pthr24349 protein   Reactome:R-HSA-2559583 2E+07
MAPKAPK5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   UniProt Homo sapiens IDA   serine/threonine-protein kinase pthr24349 protein   PMID:17254968 2E+07
VASH1 Tubulinyl-Tyr carboxypeptidase 1   regulation of cellular senescence   MGI Homo sapiens IMP   vasohibin-1-like isoform x2 pthr15750 protein   PMID:23056314 2E+07
ATR Serine/threonine-protein kinase ATR   replicative senescence   BHF-UCL Homo sapiens IMP   ataxia telangiectasia mutated atm -related pthr11139 protein   PMID:15149599 2E+07
MME Neprilysin   replicative senescence   UniProt Homo sapiens IEP   zinc metalloprotease family m13 neprilysin-related pthr11733 protein   PMID:20876573 2E+07
BCL6 B-cell lymphoma 6 protein   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
BMPR1A Bone morphogenetic protein receptor type-1A   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
NAMPT Nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q80Z29 nicotinamide phosphoribosyltransferase pthr43816 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000013043
PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial   regulation of cellular senescence   UniProt Homo sapiens IDA   polyribonucleotide nucleotidyltransferase pthr11252 protein   PMID:16055741 2E+07
SRF Serum response factor   cellular senescence   BHF-UCL Homo sapiens IMP   serum response factor homolog pthr48019 protein   PMID:15282327 2E+07
CDK6 Cyclin-dependent kinase 6   negative regulation of cellular senescence   UniProt Homo sapiens IDA   cell division protein kinase pthr24056 protein   PMID:17420273 2E+07
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
PLK2 Serine/threonine-protein kinase PLK2   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
Retinoblastoma-like protein 1   negative regulation of cellular senescence occurs inmicrovascular endothelial cell BHF-UCL Homo sapiens IMP   retinoblastoma-associated protein rb -related pthr13742 protein   PMID:28595801 2E+07  
MAGEA2 Melanoma-associated antigen 2   cellular senescence   UniProt Homo sapiens IDA   melanoma-associated antigen mage antigen pthr11736 protein   PMID:22117195 2E+07
KAT6A Histone acetyltransferase KAT6A   cellular senescence   UniProt Homo sapiens IMP   histone acetyltransferase pthr10615 protein   PMID:23431171 2E+07
MAP3K5 Mitogen-activated protein kinase kinase kinase 5   cellular senescence   Reactome Homo sapiens TAS   serine/threonine protein kinase pthr11584 protein   Reactome:R-HSA-2559583 2E+07
NPM1 Nucleophosmin   cell aging   UniProt Homo sapiens IMP   nucleoplasmin pthr22747 protein   PMID:12080348 2E+07
NOX4 NADPH oxidase 4   cell aging   UniProt Homo sapiens ISS UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   PMID:10869423 2E+07
NEK6 Serine/threonine-protein kinase Nek6   regulation of cellular senescence   UniProt Homo sapiens TAS   mitogen-activated protein kinase kinase kinase 20-related pthr43289 protein   PMID:21200151 2E+07
MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
ROMO1 Reactive oxygen species modulator 1   replicative senescence   GO_Central Homo sapiens IMP   reactive oxygen species modulator 1 pthr28525 protein   PMID:18836179 2E+07
MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
MAPK9 Mitogen-activated protein kinase 9   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
MAPK8 Mitogen-activated protein kinase 8   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
WRN Werner syndrome ATP-dependent helicase   cell aging   UniProt Homo sapiens IMP   dna helicase recq family member pthr13710 protein   PMID:18212065 2E+07
WRN Werner syndrome ATP-dependent helicase   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
MORC3 MORC family CW-type zinc finger protein 3   cell aging   MGI Homo sapiens IDA   zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   PMID:17332504 2E+07
MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1   cellular senescence   BHF-UCL Homo sapiens IMP   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   PMID:9765203 2E+07
CHEK1 Serine/threonine-protein kinase Chk1   replicative senescence   BHF-UCL Homo sapiens NAS   serine/threonine kinase pthr24343 protein   PMID:15149599 2E+07
TERT Telomerase reverse transcriptase   replicative senescence   BHF-UCL Homo sapiens IMP   telomerase reverse transcriptase pthr12066 protein   PMID:9454332 2E+07
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence occurs invascular associated smooth muscle cell BHF-UCL Homo sapiens IMP   telomerase reverse transcriptase pthr12066 protein   PMID:11313459 2E+07
part ofcellular response to hypoxia
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence occurs inaortic endothelial cell BHF-UCL Homo sapiens IDA   telomerase reverse transcriptase pthr12066 protein   PMID:11927518 2E+07
MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
SMC6 AAA_23 domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q96SB8   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
YPEL3 Yippee domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P61236   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P28749   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9R1K5   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P02340   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P04637   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P04637   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P02340   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000013807
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Homo sapiens ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
URS00007E4E8E_9615 Canis lupus familiaris (dog) microRNA cfa-mir-342 precursor   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000027000B_9615 Canis lupus familiaris (dog) microRNA cfa-mir-370 precursor   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS0000EFD174_9615 Canis lupus familiaris (dog) Cfa-Mir-370 stem-loop   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
KRAS GTPase KRas   positive regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P08644 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000012588
HRAS GTPase HRas   cellular senescence   BHF-UCL Homo sapiens IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:9054499 2E+07
HRAS GTPase HRas   cellular senescence   GO_Central Homo sapiens IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
PRKCD Protein kinase C delta type   cellular senescence   BHF-UCL Homo sapiens IMP   serine/threonine-protein kinase pthr24356 protein   PMID:15282327 2E+07
MNT Max-binding protein MNT   cell aging   Ensembl Homo sapiens IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
TERF2 Telomeric repeat-binding factor 2   cellular senescence   BHF-UCL Homo sapiens NAS   telomeric repeat-binding factor 2 terf2 pthr46833 protein   PMID:17395247 2E+07
TERF2 Telomeric repeat-binding factor 2   negative regulation of cellular senescence occurs inaortic endothelial cell BHF-UCL Homo sapiens IMP   telomeric repeat-binding factor 2 terf2 pthr46833 protein   PMID:11927518 2E+07
MAPK10 Mitogen-activated protein kinase 10   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
CDK1 Cyclin-dependent kinase 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:P39951 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000070138
NEK4 Serine/threonine-protein kinase Nek4   regulation of cellular senescence   UniProt Homo sapiens IMP   mitogen-activated kinase kinase kinase pthr24361 protein   PMID:22851694 2E+07
CITED2 Cbp/p300-interacting transactivator 2   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99MA1 melanocyte specific gene related cited pthr17045 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000074276
KIR2DL4 Killer cell immunoglobulin-like receptor 2DL4   positive regulation of cellular senescence   UniProt Homo sapiens IDA   mhc class i nk cell receptor pthr11738 protein   PMID:23184984 2E+07
KAT5 Histone acetyltransferase KAT5   cellular senescence   Reactome Homo sapiens TAS   histone acetyltransferase pthr10615 protein   Reactome:R-HSA-2559583 2E+07
PRELP Prolargin   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
PDCD4 Programmed cell death protein 4   cell aging   UniProt Homo sapiens IDA   programmed cell death 4 pthr12626 protein   PMID:12054647 2E+07
MAPK11 Mitogen-activated protein kinase 11   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Homo sapiens IDA   ribosomal protein l7ae family member pthr23105 protein   PMID:18678645 2E+07
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens IMP   mitogen-activated kinase kinase kinase pthr24361 protein   PMID:28640956 2E+07
TWIST1 Twist-related protein 1   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP   basic helix-loop-helix transcription factor, twist pthr23349 protein   PMID:17690110 2E+07
PRELP LRRNT domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9JK53   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O15119   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
TBX2 T-box transcription factor TBX2   cellular senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000024 2E+07
ABI3 SH3 domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9P2A4   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
WNT16 Protein Wnt   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
MORC3 CW-type domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
TP53 Cellular tumor antigen p53   cell aging   UniProt Canis lupus familiaris ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P10417   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
RSL1D1 Ribosomal L1 domain containing 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
Methyltransf_25 domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07  
ensembl:ENSMUSP00000140836  
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
HMGA1 High mobility group AT-hook protein 1   oncogene-induced cell senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000308227
HMGA1 High mobility group AT-hook protein 1   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000308227
MNT BHLH domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
SERPINE1 SERPIN domain-containing protein   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000223095
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000013807
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
MME Atriopeptidase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P08473   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
WRN DNA helicase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O09053   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
ZMPSTE24 CAAX prenyl protease   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
TERF2 Telomeric repeat-binding factor   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q15554   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
CGAS Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q8C6L5   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q6P1E1   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P51957   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
PML PML nuclear body scaffold   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P29590   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
LMNA Lamin A/C   positive regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P02545   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
BRCA2 Tower domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q13207   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P78540   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Canis lupus familiaris IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
ECRG4 ECRG4 augurin precursor   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q99LS0   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000027217
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
B2M Beta-2-microglobulin   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P61769   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000497910
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q53EL6   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
ARNTL Aryl hydrocarbon receptor nuclear translocator like   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9WTL8   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000147989
ARNTL Aryl hydrocarbon receptor nuclear translocator like   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9WTL8   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000147989
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
BGLAP Osteocalcin   cell aging   Ensembl Homo sapiens IEA UniProtKB:P04640 osteocalcin pthr14235 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000026530
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Homo sapiens IMP   e3 ubiquitin-protein ligase march5 pthr46283 protein   PMID:20103533 2E+07
ZKSCAN3 Zinc finger protein with KRAB and SCAN domains 3   negative regulation of cellular senescence   UniProt Homo sapiens IMP   zinc finger and scan domain-containing pthr23226 protein   PMID:23434374 2E+07
LMNA Prelamin-A/C   positive regulation of cell aging   UniProt Homo sapiens IDA   lamin dm0-related pthr45721 protein   PMID:20458013 2E+07
ERCC1 DNA excision repair protein ERCC-1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:P07903 excision repair cross-complementing 1 ercc1 pthr12749 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003645
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   BHF-UCL Homo sapiens IDA   d-dopachrome decarboxylase pthr11954 protein   PMID:10562313 2E+07
TBX3 T-box transcription factor TBX3   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11689487 2E+07
TBX3 T-box transcription factor TBX3   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11748239 2E+07
TBX3 T-box transcription factor TBX3   cellular senescence   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:22002537 2E+07
YBX1 CSD domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P62960   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589
Lam Lamin   cell aging   FlyBase Drosophila melanogaster IMP   lamin dm0-related pthr45721 protein   FB:FBrf0215933 2E+07
PMID:18494863
kuk kugelkern   cell aging   FlyBase Drosophila melanogaster IMP     protein   FB:FBrf0215933 2E+07
PMID:18494863
Cd36_86310     negative regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_32250     cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
BUD6     extrachromosomal circular DNA localization involved in cell aging   CGD Candida albicans SC5314 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_204790     cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_601870     replicative senescence   CGD Candida parapsilosis CDC317 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
B9J08_004233     extrachromosomal circular DNA localization involved in cell aging   CGD NCBITaxon:498019 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
B9J08_005133     cell aging   CGD NCBITaxon:498019 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0E04246g     regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
SSA2     negative regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000003947 heat shock protein 70kda pthr19375 gene_product   CGD_REF:CAL0121033 2E+07
CAWG_06119     replicative senescence   CGD Candida albicans WO-1 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
PGUG_05750     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CAWG_05096     replicative senescence   CGD Candida albicans WO-1 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
PGUG_05881     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
Aacu16872_051463     replicative senescence   AspGD NCBITaxon:690307 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspka1_0181635     replicative senescence   AspGD Aspergillus luchuensis IFO 4308 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Asptu1_0194884     replicative senescence   AspGD NCBITaxon:767770 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
hsp70     negative regulation of cell aging   AspGD Aspergillus fumigatus IEA SGD:S000003947   gene_product   AspGD_REF:ASPL0000000005 2E+07
AFL2T_08396     replicative senescence   AspGD Aspergillus flavus NRRL3357 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
NFIA_074550     replicative senescence   AspGD Aspergillus fischeri NRRL 181 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090012000995     negative regulation of cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000003947   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspzo1_0162899     replicative senescence   AspGD NCBITaxon:41063 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
PDCD4 Programmed cell death protein 4   cell aging   UniProt Gallus gallus ISS UniProtKB:Q53EL6   protein   GO_REF:0000024 2E+07
PNPT1 Polyribonucleotide nucleotidyltransferase   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
LELG_00697     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
SSA1     negative regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0G07271g     negative regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_04050     negative regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_01930     replicative senescence   CGD Candida tropicalis MYA-3404 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CORT_0F02830     replicative senescence   CGD NCBITaxon:1136231 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CORT_0A07030     replicative senescence   CGD NCBITaxon:1136231 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CAWG_00610     replicative senescence   CGD Candida albicans WO-1 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
LELG_04803     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
DEHA2C11044g     replicative senescence   CGD Debaryomyces hansenii CBS767 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_05424     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_303700     regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_206750     extrachromosomal circular DNA localization involved in cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
PGUG_04837     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0B01771g     extrachromosomal circular DNA accumulation involved in cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000002517   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0B01771g     regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000002517   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_00201     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_04008     replicative senescence   CGD Candida tropicalis MYA-3404 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_63010     replicative senescence   CGD Candida dubliniensis CD36 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
TLC1     replicative senescence   CGD [Candida] glabrata CBS 138 IMP     gene_product   CGD_REF:CAL0124495 2E+07
PMID:19840797
TSA1     negative regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000004490 thioredoxin peroxidase pthr10681 gene_product   CGD_REF:CAL0121033 2E+07
EST2     replicative senescence   CGD [Candida] glabrata CBS 138 IMP     gene_product   CGD_REF:CAL0124495 2E+07
PMID:19840797
SGS1     replicative senescence   CGD Candida albicans SC5314 IMP   dna helicase recq family member pthr13710 gene_product   CGD_REF:CAL0119368 2E+07
PMID:18691183
LELG_02334     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_03791     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CORT_0C07310     replicative senescence   CGD NCBITaxon:1136231 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_07650     extrachromosomal circular DNA localization involved in cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
SSA2     negative regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_50620     regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
GCN5     cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_02793     replicative senescence   CGD Candida tropicalis MYA-3404 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CTRG_02792     replicative senescence   CGD Candida tropicalis MYA-3404 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
B9J08_003364     negative regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
B9J08_000645     negative regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
GCN5     cell aging   CGD Candida albicans SC5314 IEA SGD:S000003484 gh11602p pthr45750 gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_404840     negative regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0A00891g     extrachromosomal circular DNA localization involved in cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
C5_00620W_A     regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000004500 cgi-121 family member pthr15840 gene_product   CGD_REF:CAL0121033 2E+07
DEHA2F03388g     replicative senescence   CGD Debaryomyces hansenii CBS767 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
ECRG4 Uncharacterized protein   cellular senescence   GO_Central Felis catus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
hsp70     negative regulation of cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000000004   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspbr1_0050256     replicative senescence   AspGD Aspergillus brasiliensis CBS 101740 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Tbx3 T-box 3   cell aging   MGI Mus musculus ISO UniProtKB:O15119 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx3 T-box 3   cell aging   MGI Mus musculus IDA   t-box protein-related pthr11267 protein   MGI:MGI:2159048 2E+07
PMID:11748239
Tbx3 T-box 3   cellular senescence   MGI Mus musculus ISO UniProtKB:O15119 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx2 T-box 2   cell aging   MGI Mus musculus ISO UniProtKB:Q13207 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx2 T-box 2   cell aging   MGI Mus musculus IDA   t-box protein-related pthr11267 protein   MGI:MGI:2159048 2E+07
PMID:11748239
Tbx2 T-box 2   cellular senescence   MGI Mus musculus ISO UniProtKB:Q13207 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Bcl2 B cell leukemia/lymphoma 2   cell aging occurs inEMAPA:18767 MGI Mus musculus IMP MGI:MGI:2156165 bcl-2 related pthr11256 protein   MGI:MGI:62849 2E+07
occurs inT cellmore... PMID:8372353
B2m beta-2 microglobulin   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P61769 mhc class ii-related pthr19944 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Srf serum response factor   cellular senescence   MGI Mus musculus ISO UniProtKB:P11831 serum response factor homolog pthr48019 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt1 wingless-type MMTV integration site family, member 1   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:P04628 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir290a microRNA 290a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Terf2 telomeric repeat binding factor 2   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Fbxo5 F-box protein 5   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir193b microRNA 193b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir671 microRNA 671   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Romo1 reactive oxygen species modulator 1   replicative senescence   MGI Mus musculus ISO UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pawr PRKC, apoptosis, WT1, regulator   positive regulation of cellular senescence occurs infibroblast of cardiac tissue BHF-UCL Mus musculus IMP   prostate apoptosis response protein par-4 pthr15093 protein   MGI:MGI:5648604 2E+07
PMID:25472717
Mir378b microRNA 378b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir370 microRNA 370   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34c microRNA 34c   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34b microRNA 34b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34a microRNA 34a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir342 microRNA 342   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Twist1 twist basic helix-loop-helix transcription factor 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir31 microRNA 31   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir296 microRNA 296   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir25 microRNA 25   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Npm1 nucleophosmin 1   cell aging   MGI Mus musculus ISO UniProtKB:P06748 nucleoplasmin pthr22747 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir19b-1 microRNA 19b-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Smc6 structural maintenance of chromosomes 6   cellular senescence   MGI Mus musculus ISO UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir877 microRNA 877   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Spi1 spleen focus forming virus (SFFV) proviral integration oncogene   oncogene-induced cell senescence occurs infibroblast ARUK-UCL Mus musculus IDA   ets pthr11849 protein   MGI:MGI:6478061 2E+07
occurs inhematopoietic stem cellmore... PMID:28912174
Cdk1 cyclin-dependent kinase 1   cell aging   MGI Mus musculus ISO RGD:2319 cell division protein kinase pthr24056 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mapkapk5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mapkapk5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   UniProt Mus musculus IMP   serine/threonine-protein kinase pthr24349 protein   MGI:MGI:3697960 2E+07
PMID:17254968
Calr calreticulin   cellular senescence   BHF-UCL Mus musculus IMP   calreticulin and calnexin pthr11073 protein   MGI:MGI:3813434 2E+07
PMID:14726956
Calr calreticulin   cellular senescence   MGI Mus musculus ISO UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Sus scrofa ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P36895   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
ROMO1 Reactive oxygen species modulator 1   replicative senescence   UniProt Sus scrofa ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
Trp53 transformation related protein 53   cell aging   MGI Mus musculus IGI MGI:MGI:1920086 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:3692019 2E+07
PMID:17053789
Trp53 transformation related protein 53   cell aging   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   positive regulation of cell aging   BHF-UCL Mus musculus IMP   cellular tumor antigen p53 pthr11447 protein   MGI:MGI:5142390 2E+07
PMID:10562313
Trp53 transformation related protein 53   replicative senescence   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:2139971 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:5504576 2E+07
PMID:22904064
Ilk integrin linked kinase   cell aging   MGI Mus musculus ISO RGD:620063 serine/threonine-protein kinase tnni3k-related pthr44329 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mnt max binding protein   cell aging   MGI Mus musculus IMP MGI:MGI:2678322 max dimerization, mad pthr11969 protein   MGI:MGI:2675510 2E+07
PMID:12970171
Mir125b-1 microRNA 125b-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir183 microRNA 183   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir19b-2 microRNA 19b-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Map2k1 mitogen-activated protein kinase kinase 1   cellular senescence   MGI Mus musculus ISO UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cav1 caveolin 1, caveolae protein   cellular senescence   MGI Mus musculus ISO RGD:2280 caveolin pthr10844 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cgas cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Mus musculus IDA   cell fate determining protein mab21-related pthr10656 protein   MGI:MGI:5909142 2E+07
PMID:28759028
Abi3 ABI family member 3   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mapk14 mitogen-activated protein kinase 14   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Rwdd1 RWD domain containing 1   cell aging   CAFA Mus musculus IDA   rwd domain-containing protein pthr12292 protein   MGI:MGI:5882884 2E+07
PMID:18761815
Mir24-2 microRNA 24-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir199a-2 microRNA 199a-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir128-2 microRNA 128-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir125b-2 microRNA 125b-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Rsl1d1 ribosomal L1 domain containing 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wrn Werner syndrome RecQ like helicase   cell aging   MGI Mus musculus ISO UniProtKB:Q14191 dna helicase recq family member pthr13710 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wrn Werner syndrome RecQ like helicase   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2386438 dna helicase recq family member pthr13710 protein   MGI:MGI:1355173 2E+07
PMID:10757812
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga2 high mobility group AT-hook 2   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Mus musculus IMP   high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:5582375 2E+07
PMID:23072816
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Vash1 vasohibin 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   MGI:MGI:5463671 2E+07
PMID:23056314
Kat6a K(lysine) acetyltransferase 6A   cellular senescence   MGI Mus musculus ISO UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Brca2 breast cancer 2, early onset   cell aging   MGI Mus musculus IMP MGI:MGI:2653913 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   MGI:MGI:1277623 2E+07
MGI:MGI:2653914 PMID:9699678
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   UniProt Mus musculus IMP   circadian protein clock/arnt/bmal/pas pthr23042 protein   MGI:MGI:5554364 2E+07
PMID:22101268
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   UniProt Mus musculus IMP   circadian protein clock/arnt/bmal/pas pthr23042 protein   MGI:MGI:5554364 2E+07
PMID:22101268
Mir23b microRNA 23b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Map3k3 mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pot1b protection of telomeres 1B   cell aging   MGI Mus musculus IDA   protection of telomeres 1 pthr14513 protein   MGI:MGI:3692019 2E+07
PMID:17053789
Pot1b protection of telomeres 1B   cell aging   MGI Mus musculus IGI MGI:MGI:98834 protection of telomeres 1 pthr14513 protein   MGI:MGI:3692019 2E+07
PMID:17053789
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Chlorocebus aethiops ISS UniProtKB:Q9NX47   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Pan troglodytes ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
Pten phosphatase and tensin homolog   negative regulation of cell aging   BHF-UCL Mus musculus IMP   phosphatase with homology to tensin pthr12305 protein   MGI:MGI:5009768 2E+07
PMID:21241890
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1   replicative senescence   MGI Mus musculus ISO UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir378d microRNA 378d   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Zfp354a zinc finger protein 354A   nucleolar fragmentation   MGI Mus musculus ISO RGD:2967 ip01015p-related pthr24377 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cdk6 cyclin-dependent kinase 6   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q00534 cell division protein kinase pthr24056 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Eef1e1 eukaryotic translation elongation factor 1 epsilon 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O43324 eukaryotic translation elongation factor 1 epsilon-1 pthr44490 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pdcd4 programmed cell death 4   cell aging   MGI Mus musculus ISO UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Ypel3 yippee like 3   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Suv39h1 suppressor of variegation 3-9 1   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2445449 histone-lysine n-methyltransferase suv39h pthr46223 protein   MGI:MGI:5913114 2E+07
PMID:23695662
Dnaja3 DnaJ heat shock protein family (Hsp40) member A3   cell aging   MGI Mus musculus IDA   dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1338938 tyrosine-protein kinase pthr24418 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase   negative regulation of cellular senescence regulates→occurs inosteoblast MGI Mus musculus IGI MGI:MGI:104738 tyrosine-protein kinase pthr24418 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Prkcd protein kinase C, delta   cellular senescence   MGI Mus musculus ISO UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
polo like kinase 2   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Mus musculus IMP   serine/threonine-protein kinase plk pthr24345 protein   MGI:MGI:6120300 2E+07  
PMID:27908889  
Mir16-2 microRNA 16-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Icmt isoprenylcysteine carboxyl methyltransferase   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1890508 protein-s isoprenylcysteine o-methyltransferase pthr12714 protein   MGI:MGI:5500993 2E+07
PMID:23686339
TP53 Cellular tumor antigen p53   cell aging   UniProt Meriones unguiculatus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Marmota monax ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
nsmce2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q96MF7   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Bos indicus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
P50244 S-adenosylmethionine decarboxylase proenzyme   positive regulation of cell aging   UniProt Trypanosoma brucei brucei IMP     protein   PMID:18949025 2E+07
HMGA2 High mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Macaca mulatta ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
HMGA2 High mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Macaca mulatta ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Felis catus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Pongo abelii ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Macaca mulatta ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
A5HNV6 Inactive S-adenosylmethionine decarboxylase prozyme   positive regulation of cell aging   UniProt Trypanosoma brucei brucei IMP     protein   PMID:18949025 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Callithrix jacchus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Callithrix jacchus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Myotis lucifugus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Myotis lucifugus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca mulatta ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca fascicularis ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Mesocricetus auratus ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Mesocricetus auratus ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Chlorocebus aethiops ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Macaca fascicularis ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Heterocephalus glaber ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Pongo pygmaeus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Hylobates lar ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca fuscata fuscata ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca fascicularis ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca mulatta ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Sapajus apella ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Callithrix jacchus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Equus caballus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Myotis lucifugus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
id2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Xenopus tropicalis ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
romo1 Reactive oxygen species modulator 1   replicative senescence   UniProt Xenopus tropicalis ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
romo1 Reactive oxygen species modulator 1   replicative senescence   UniProt Xenopus laevis ISS UniProtKB:P60602   protein   GO_REF:0000024 2E+07
smc6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q96SB8   protein   GO_REF:0000024 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Neovison vison ISS UniProtKB:P05121   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Nomascus leucogenys ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
ybx1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P62960   protein   GO_REF:0000024 2E+07
K7_YNL305C K7_Ynl305cp   positive regulation of cell aging   UniProt Saccharomyces cerevisiae Kyokai no. 7 IMP     protein   PMID:21673659 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Cricetulus griseus ISS UniProtKB:P17096   protein   GO_REF:0000024 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Cricetulus griseus ISS UniProtKB:P17096   protein   GO_REF:0000024 2E+07
F7I934 Uncharacterized protein   oncogene-induced cell senescence   UniProt Callithrix jacchus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
F7I934 Uncharacterized protein   positive regulation of cellular senescence   UniProt Callithrix jacchus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
MME Neprilysin   replicative senescence   UniProt Pongo abelii ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:Q8TCS8   protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Pongo abelii ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:O76021   protein   GO_REF:0000024 2E+07
Arntl Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Nannospalax galili ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
Arntl Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Nannospalax galili ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
id2-b DNA-binding protein inhibitor ID-2-B   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
smc5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Takifugu rubripes ISS UniProtKB:Q8IY18   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Oryctolagus cuniculus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Monodelphis domestica ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:P62960   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Cavia porcellus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Tupaia belangeri ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Bos grunniens ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Macaca fascicularis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
smc5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q8IY18   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Gorilla gorilla gorilla ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
smc6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Takifugu rubripes ISS UniProtKB:Q96SB8   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Ailuropoda melanoleuca ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Ailuropoda melanoleuca ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Cavia porcellus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Ovis aries ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
HMGI-C HMGI family protein HMGI-C   oncogene-induced cell senescence   UniProt Capra hircus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
HMGI-C HMGI family protein HMGI-C   positive regulation of cellular senescence   UniProt Capra hircus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
id2-a DNA-binding protein inhibitor ID-2-A   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
Akt3 thymoma viral proto-oncogene 3   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt16 wingless-type MMTV integration site family, member 16   replicative senescence   MGI Mus musculus ISO UniProtKB:Q9UBV4 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt16 wingless-type MMTV integration site family, member 16   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q9UBV4 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tert telomerase reverse transcriptase   replicative senescence   MGI Mus musculus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tert telomerase reverse transcriptase   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir99a microRNA 99a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir30a microRNA 30a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir27a microRNA 27a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir24-1 microRNA 24-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir23a microRNA 23a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir22 microRNA 22   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir211 microRNA 211   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir20a microRNA 20a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir199a-1 microRNA 199a-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir191 microRNA 191   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir188 microRNA 188   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir16-1 microRNA 16-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir15b microRNA 15b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir15a microRNA 15a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir140 microRNA 140   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir134 microRNA 134   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir132 microRNA 132   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir130a microRNA 130a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir128-1 microRNA 128-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir125a microRNA 125a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7i microRNA let7i   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7g microRNA let7g   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Nampt nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   MGI Mus musculus ISO RGD:631365 nicotinamide phosphoribosyltransferase pthr43816 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mirlet7f-2 microRNA let7f-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7f-1 microRNA let7f-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7d microRNA let7d   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7b microRNA let7b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Ctc1 CTS telomere maintenance complex component 1   replicative senescence   MGI Mus musculus IMP MGI:MGI:5427642 cst complex subunit ctc1 pthr14865 protein   MGI:MGI:5426340 2E+07
PMID:22531781
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2   cell aging   RGD Rattus norvegicus IEP   melanocyte specific gene related cited pthr17045 gene   PMID:20569237 2E+07
RGD:5147849
B2m beta-2 microglobulin   positive regulation of cellular senescence regulates→occurs inepithelial cell of lung RGD Rattus norvegicus ISO UniProtKB:P61769 mhc class ii-related pthr19944 gene   RGD:1624291 2E+07
part ofcellular response to nicotine
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   UniProt Rattus norvegicus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 gene   GO_REF:0000024 2E+07
RGD:1600115
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO MGI:1096381 circadian protein clock/arnt/bmal/pas pthr23042 gene   RGD:1624291 2E+07
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 gene   GO_REF:0000024 2E+07
RGD:1600115
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1096381 circadian protein clock/arnt/bmal/pas pthr23042 gene   RGD:1624291 2E+07
Smc5 structural maintenance of chromosomes 5   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 gene   RGD:1624291 2E+07
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q96MF7 uncharacterized pthr21330 gene   GO_REF:0000024 2E+07
RGD:1600115
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96MF7 uncharacterized pthr21330 gene   RGD:1624291 2E+07
Terf2 telomeric repeat binding factor 2   negative regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 gene   RGD:1624291 2E+07
Zkscan3 zinc finger with KRAB and SCAN domains 3   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9BRR0 zinc finger and scan domain-containing pthr23226 gene   RGD:1624291 2E+07
Rsl1d1 ribosomal L1 domain containing 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O76021   gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cell aging   RGD Rattus norvegicus ISO MGI:98495 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cell aging   UniProt Rattus norvegicus ISS UniProtKB:O15119 t-box protein-related pthr11267 gene   GO_REF:0000024 2E+07
RGD:1600115
Tbx3 T-box transcription factor 3   cell aging   RGD Rattus norvegicus ISO UniProtKB:O15119 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:O15119 t-box protein-related pthr11267 gene   GO_REF:0000024 2E+07
RGD:1600115
Tbx3 T-box transcription factor 3   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O15119 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Ing2 inhibitor of growth family, member 2   regulation of cellular senescence   InterPro Rattus norvegicus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 gene   GO_REF:0000002 2E+07
RGD:1600115
Twist1 twist family bHLH transcription factor 1   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 gene   RGD:1624291 2E+07
Spi1 Spi-1 proto-oncogene   oncogene-induced cell senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:98282 ets pthr11849 gene   RGD:1624291 2E+07
occurs inhematopoietic stem cellmore...
Mirlet7f1 microRNA let-7f-1   cell aging   RGD Rattus norvegicus ISO MGI:2676798   gene   RGD:1624291 2E+07
Calr calreticulin   cellular senescence   RGD Rattus norvegicus ISO MGI:88252 calreticulin and calnexin pthr11073 gene   RGD:1624291 2E+07
Calr calreticulin   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P27797 calreticulin and calnexin pthr11073 gene   RGD:1624291 2E+07
Mir193b microRNA 193b   cell aging   RGD Rattus norvegicus ISO MGI:3718458   gene   RGD:1624291 2E+07
Romo1 reactive oxygen species modulator 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 gene   RGD:1624291 2E+07
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   UniProt Rattus norvegicus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   RGD Rattus norvegicus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Suv39h1 SUV39H1 histone lysine methyltransferase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1099440   gene   RGD:1624291 2E+07
Slc30a10 solute carrier family 30, member 10   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q6XR72 fi23527p1 pthr45820 gene   RGD:1624291 2E+07
Prkcd protein kinase C, delta   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 gene UniProtKB:A0A140UHX0 GO_REF:0000107 2E+07
ensembl:ENSP00000331602 RGD:1600115
Prkcd protein kinase C, delta   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 gene   RGD:1624291 2E+07
Cdkn2b cyclin-dependent kinase inhibitor 2B   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P42772 family not named pthr24201 gene UniProtKB:Q5PQW4 GO_REF:0000107 2E+07
ensembl:ENSP00000276925 RGD:1600115
Cdkn2b cyclin-dependent kinase inhibitor 2B   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42772 family not named pthr24201 gene   RGD:1624291 2E+07
Wnt1 Wnt family member 1   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P04628 wnt related pthr12027 gene   RGD:1624291 2E+07
Igf1r insulin-like growth factor 1 receptor   cellular senescence   RGD Rattus norvegicus IEP   tyrosine-protein kinase receptor pthr24416 gene   PMID:19862643 2E+07
RGD:10045872
Id2 inhibitor of DNA binding 2   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 gene   GO_REF:0000024 2E+07
RGD:1600115
Id2 inhibitor of DNA binding 2   cellular senescence   RGD Rattus norvegicus ISO MGI:96397 dna-binding protein inhibitor pthr11723 gene   RGD:1624291 2E+07
Icam1 intercellular adhesion molecule 1   cell aging   RGD Rattus norvegicus IEP   intercellular adhesion molecule pthr13771 gene   PMID:20421514 2E+07
RGD:4145420
Hras HRas proto-oncogene, GTPase   cell aging   RGD Rattus norvegicus ISO MGI:96224 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   RGD:1624291 2E+07
Hras HRas proto-oncogene, GTPase   cellular senescence   RGD Rattus norvegicus IEP   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:17706954 2E+07
RGD:11060281
Hras HRas proto-oncogene, GTPase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   RGD:1624291 2E+07
Hras HRas proto-oncogene, GTPase   cellular senescence   GO_Central Rattus norvegicus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
Fzr1 fizzy and cell division cycle 20 related 1   negative regulation of cell aging   RGD Rattus norvegicus ISO MGI:1926790 cell division cycle 20 cdc20 fizzy -related pthr19918 gene   RGD:1624291 2E+07
Ilk integrin-linked kinase   cell aging   RGD Rattus norvegicus IMP   serine/threonine-protein kinase tnni3k-related pthr44329 gene   PMID:17234816 2E+07
RGD:2301768
Rbl1 RB transcriptional corepressor like 1   negative regulation of cellular senescence occurs inmicrovascular endothelial cell RGD Rattus norvegicus ISO UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 gene   RGD:1624291 2E+07
Pten phosphatase and tensin homolog   negative regulation of cell aging   RGD Rattus norvegicus ISO MGI:109583 phosphatase with homology to tensin pthr12305 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   cell aging   RGD Rattus norvegicus IEP   histone deacetylase sir2 family member pthr11085 gene   PMID:15501022 2E+07
RGD:10047125
Sirt1 sirtuin 1   stress-induced premature senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   negative regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO RGD:13966638 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Atr ATR serine/threonine kinase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 gene   RGD:1624291 2E+07
Nampt nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   RGD Rattus norvegicus IDA   nicotinamide phosphoribosyltransferase pthr43816 gene   PMID:28125705 2E+07
RGD:13781884
Icmt isoprenylcysteine carboxyl methyltransferase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1888594 protein-s isoprenylcysteine o-methyltransferase pthr12714 gene   RGD:1624291 2E+07
Prkdc protein kinase, DNA-activated, catalytic subunit   negative regulation of cellular senescence   RGD Rattus norvegicus IMP   ataxia telangiectasia mutated atm -related pthr11139 gene   PMID:22981234 2E+07
RGD:8696027
Mir16 microRNA 16   cell aging   RGD Rattus norvegicus ISO MGI:3618690   gene   RGD:1624291 2E+07
Stk11 serine/threonine kinase 11   positive regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO RGD:14067591 family not named pthr43895 gene   RGD:1624291 2E+07
Ecrg4 ECRG4 augurin precursor   cellular senescence   RGD Rattus norvegicus ISO MGI:1926146 augurin pthr31613 gene   RGD:1624291 2E+07
Ecrg4 ECRG4 augurin precursor   cellular senescence   GO_Central Rattus norvegicus IBA PANTHER:PTN002835855 augurin pthr31613 gene   PMID:21873635 2E+07
MGI:MGI:1926146
Rwdd1 RWD domain containing 1   cell aging   RGD Rattus norvegicus ISO MGI:1913771 rwd domain-containing protein pthr12292 gene   RGD:1624291 2E+07
Pot1b protection of telomeres 1B   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:H7BX60 protection of telomeres 1 pthr14513 gene   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000084089 RGD:1600115
Akt3 AKT serine/threonine kinase 3   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 gene UniProtKB:A0A0G2JXD7 GO_REF:0000107 2E+07
ensembl:ENSP00000500582 RGD:1600115
Akt3 AKT serine/threonine kinase 3   negative regulation of cellular senescence occurs inadult endothelial progenitor cell RGD Rattus norvegicus ISO UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 gene   RGD:1624291 2E+07
Bcl2l12 BCL2 like 12   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1922986 family not named pthr14965 gene   RGD:1624291 2E+07
Map2k1 mitogen activated protein kinase kinase 1   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 gene UniProtKB:A0A0H2UHI2 GO_REF:0000107 2E+07
ensembl:ENSP00000302486 RGD:1600115
Map2k1 mitogen activated protein kinase kinase 1   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 gene   RGD:1624291 2E+07
Marchf5 membrane associated ring-CH-type finger 5   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 gene   RGD:1624291 2E+07
Mnt MAX network transcriptional repressor   cell aging   RGD Rattus norvegicus ISO MGI:109150 max dimerization, mad pthr11969 gene   RGD:1624291 2E+07
Zmpste24 zinc metallopeptidase STE24   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1890508 caax prenyl protease 1 pthr10120 gene   RGD:1624291 2E+07
Kras KRAS proto-oncogene, GTPase   positive regulation of cellular senescence   RGD Rattus norvegicus IMP   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:17706954 2E+07
RGD:11060281
Zfp354a zinc finger protein 354A   nucleolar fragmentation   RGD Rattus norvegicus IMP   ip01015p-related pthr24377 gene   PMID:10075651 2E+07
RGD:1303369
Pdcd4 programmed cell death 4   cell aging   UniProt Rattus norvegicus ISS UniProtKB:Q53EL6 programmed cell death 4 pthr12626 gene   GO_REF:0000024 2E+07
RGD:1600115
Pdcd4 programmed cell death 4   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q53EL6 programmed cell death 4 pthr12626 gene   RGD:1624291 2E+07
Ctc1 CST telomere replication complex component 1   replicative senescence   RGD Rattus norvegicus ISO MGI:1916214 cst complex subunit ctc1 pthr14865 gene   RGD:1624291 2E+07
Brca2 BRCA2, DNA repair associated   cell aging   RGD Rattus norvegicus ISO MGI:109337 breast cancer type 2 susceptibility protein brca2 pthr11289 gene   RGD:1624291 2E+07
Brca2 BRCA2, DNA repair associated   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 gene UniProtKB:Q66MH4 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576 RGD:1600115
Bglap bone gamma-carboxyglutamate protein   cell aging   RGD Rattus norvegicus IEP   osteocalcin pthr14235 gene   PMID:19840645 2E+07
RGD:2316145
Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit   replicative senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:95412 excision repair cross-complementing 1 ercc1 pthr12749 gene   RGD:1624291 2E+07
Zmiz1 zinc finger, MIZ-type containing 1   cell aging   RGD Rattus norvegicus ISO MGI:3040693 zinc finger miz domain-containing protein pthr10782 gene   RGD:1624291 2E+07
Arg2 arginase 2   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P78540 arginase pthr43782 gene UniProtKB:G3V7H6 GO_REF:0000107 2E+07
ensembl:ENSP00000261783 RGD:1600115
Arg2 arginase 2   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P78540 arginase pthr43782 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Rattus norvegicus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   RGD Rattus norvegicus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   negative regulation of cellular senescence occurs inbone marrow cell RGD Rattus norvegicus ISO MGI:101761 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Cav1 caveolin 1   cellular senescence   RGD Rattus norvegicus IMP   caveolin pthr10844 gene   PMID:23941874 2E+07
RGD:9588563
Htt huntingtin   cell aging   RGD Rattus norvegicus ISO MGI:96067 huntington disease protein pthr10170 gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cell aging   RGD Rattus norvegicus ISO MGI:104738   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence occurs inosteoblast RGD Rattus norvegicus ISO MGI:104738   gene   RGD:1624291 2E+07
occurs inosteoblast
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
UniProtKB:Q8N726
Cdkn2a cyclin-dependent kinase inhibitor 2A   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Zfp277 zinc finger protein 277   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1890393 zinc finger protein 277 pthr13267 gene   RGD:1624291 2E+07
Lmna lamin A/C   positive regulation of cell aging   UniProt Rattus norvegicus ISS UniProtKB:P02545 lamin dm0-related pthr45721 gene   GO_REF:0000024 2E+07
RGD:1600115
Lmna lamin A/C   positive regulation of cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P02545 lamin dm0-related pthr45721 gene UniProtKB:G3V8L3 GO_REF:0000107 2E+07
ensembl:ENSP00000357283 RGD:1600115
Lmna lamin A/C   positive regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P02545 lamin dm0-related pthr45721 gene   RGD:1624291 2E+07
Lmna lamin A/C   cellular senescence   RGD Rattus norvegicus IEP   lamin dm0-related pthr45721 gene   PMID:20362703 2E+07
RGD:12791030
Sod1 superoxide dismutase 1   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 gene   GO_REF:0000024 2E+07
RGD:1600115
Sod1 superoxide dismutase 1   cell aging   RGD Rattus norvegicus ISO UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 gene   RGD:1624291 2E+07
Smc6 structural maintenance of chromosomes 6   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 gene   RGD:1624291 2E+07
Dnaja3 DnaJ heat shock protein family (Hsp40) member A3   cell aging   RGD Rattus norvegicus ISO MGI:1933786 dnaj homolog subfamily a member 3, mitochondrial pthr44145 gene   RGD:1624291 2E+07
Wnt16 Wnt family member 16   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UBV4 wnt related pthr12027 gene   RGD:1624291 2E+07
Wnt16 Wnt family member 16   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UBV4 wnt related pthr12027 gene   RGD:1624291 2E+07
Foxm1 forkhead box M1   negative regulation of cell aging   Ensembl Rattus norvegicus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 gene UniProtKB:D3ZLE1 GO_REF:0000107 2E+07
ensembl:ENSP00000352901 RGD:1600115
Foxm1 forkhead box M1   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:Q08050 forkhead box protein m1 pthr46878 gene   RGD:1624291 2E+07
Bcl2 BCL2, apoptosis regulator   cell aging occurs inEMAPA:18767 RGD Rattus norvegicus ISO MGI:88138 bcl-2 related pthr11256 gene   RGD:1624291 2E+07
occurs inT cellmore...
Bcl2 BCL2, apoptosis regulator   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P10417 bcl-2 related pthr11256 gene UniProtKB:F1LNV0 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371 RGD:1600115
Cdk1 cyclin-dependent kinase 1   cell aging   RGD Rattus norvegicus IDA   cell division protein kinase pthr24056 gene   PMID:15695611 2E+07
RGD:2301352
Mtor mechanistic target of rapamycin kinase   cell aging   RGD Rattus norvegicus IEP   ataxia telangiectasia mutated atm -related pthr11139 gene   PMID:19698731 2E+07
RGD:10003167
Abi3 ABI family, member 3   positive regulation of cellular senescence part ofdefense response to tumor cell RGD Rattus norvegicus ISO UniProtKB:Q9P2A4 abl interactor family member pthr10460 gene   RGD:1624291 2E+07
Mirlet7g microRNA let-7g   cell aging   RGD Rattus norvegicus ISO MGI:2676800   gene   RGD:1624291 2E+07
Ybx1 Y box binding protein 1   negative regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 gene   GO_REF:0000024 2E+07
RGD:1600115
Ybx1 Y box binding protein 1   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P62960 cold shock domain containing proteins pthr11544 gene UniProtKB:Q3ZAV2 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589 RGD:1600115
Nek4 NIMA-related kinase 4   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 gene   RGD:1624291 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   extrachromosomal circular DNA accumulation involved in cell aging   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:O13329 PMID:10230397 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:O13329 PMID:25822194 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IGI SGD:S000004500   protein UniProtKB:O13329 PMID:25822194 2E+07
MED2 Subunit of the RNA polymerase II mediator complex   replicative senescence   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:Q12124 PMID:33045248 2E+07
SSA1 ATPase involved in protein folding and NLS-directed nuclear transport   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   heat shock protein 70kda pthr19375 protein UniProtKB:P10591 PMID:27264606 2E+07
Atm ATM serine/threonine kinase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13315 ataxia telangiectasia mutated atm -related pthr11139 gene   RGD:1624291 2E+07
Eef1e1 eukaryotic translation elongation factor 1 epsilon 1   positive regulation of cellular senescence occurs inmesenchymal stem cell RGD Rattus norvegicus ISO UniProtKB:O43324 eukaryotic translation elongation factor 1 epsilon-1 pthr44490 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cell aging   RGD Rattus norvegicus ISO MGI:98494 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q13207 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q13207 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   ParkinsonsUK-UCL Rattus norvegicus ISS UniProtKB:O60313 dynamin pthr11566 gene   GO_REF:0000024 2E+07
RGD:1600115
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O60313 dynamin pthr11566 gene   RGD:1624291 2E+07
CGI121 Component of the EKC/KEOPS complex   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   cgi-121 family member pthr15840 protein UniProtKB:Q03705 PMID:25822194 2E+07
CGI121 Component of the EKC/KEOPS complex   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IGI SGD:S000002517 cgi-121 family member pthr15840 protein UniProtKB:Q03705 PMID:25822194 2E+07
SSA2 HSP70 family ATP-binding protein   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   heat shock protein 70kda pthr19375 protein UniProtKB:P10592 PMID:27264606 2E+07
TSA1 Thioredoxin peroxidase   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   thioredoxin peroxidase pthr10681 protein UniProtKB:P34760 PMID:27264606 2E+07
BUD6 Actin- and formin-interacting protein   extrachromosomal circular DNA localization involved in cell aging   SGD Saccharomyces cerevisiae S288C IMP   p140cap/snip-related pthr22741 protein UniProtKB:P41697 PMID:18660802 2E+07
ALB3 ALBINO 3   regulation of cell aging   TAIR Arabidopsis thaliana IMP   oxa1 pthr12428 protein TAIR:locus:2053230 TAIR:Publication:501732666 2E+07
PMID:18713382
HRAS HRas proto-oncogene, GTPase   cellular senescence   GO_Central Equus caballus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
ECRG4 Chromosome 15 C2orf40 homolog   cellular senescence   GO_Central Equus caballus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS GTPase HRas isoform 1   cellular senescence   GO_Central Sus scrofa IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
G3R5Z7 Chromosome 2 open reading frame 40   cellular senescence   GO_Central Gorilla gorilla gorilla IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS HRas proto-oncogene, GTPase   cellular senescence   GO_Central Canis lupus familiaris IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
HRAS HRAS isoform 2   cellular senescence   GO_Central Pan troglodytes IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C2orf40 Uncharacterized protein   cellular senescence   GO_Central Monodelphis domestica IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
C2AH2orf40 C2orf40 isoform 1   cellular senescence   GO_Central Pan troglodytes IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
XB-GENE-997587 Augurin   cellular senescence   GO_Central Xenopus tropicalis IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
A0A2I2YWA2 HRas proto-oncogene, GTPase   cellular senescence   GO_Central Gorilla gorilla gorilla IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
HRAS GTPase HRas isoform 1   cellular senescence   GO_Central Macaca mulatta IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C10H2orf40 Chromosome 10 C2orf40 homolog   cellular senescence   GO_Central Canis lupus familiaris IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS Uncharacterized protein   cellular senescence   GO_Central Felis catus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C2orf40 Uncharacterized protein   cellular senescence   GO_Central Sus scrofa IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635  
Source: AmiGo 2

Aging and Senescence

      Aging Cell Genes
Gene/product Gene/product name Annotation qualifier GO class (direct) Annotation extension Contributor Organism Evidence Evidence with PANTHER family Type Isoform Reference Date
Q32KM8 Augurin   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
c21h2orf40 Uncharacterized protein   cellular senescence   GO_Central Oryzias latipes IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
W5MQP3 Uncharacterized protein   cellular senescence   GO_Central Lepisosteus oculatus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS Uncharacterized protein   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C11H2orf40 Uncharacterized protein   cellular senescence   GO_Central Bos taurus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
C2orf40 Chromosome 2 open reading frame 40   cellular senescence   GO_Central Anolis carolinensis IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
Aspfo1_0209226     replicative senescence   AspGD NCBITaxon:1137211 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AFUB_060320     replicative senescence   AspGD Aspergillus fumigatus A1163 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspgl1_0177235     replicative senescence   AspGD NCBITaxon:1160497 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
budA     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus niger CBS 513.88 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
An07g07660     regulation of cell aging   AspGD Aspergillus niger CBS 513.88 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Afu2g03210     regulation of cell aging   AspGD Aspergillus fumigatus IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
ATET_02002     replicative senescence   AspGD Aspergillus terreus NIH2624 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspsy1_0143497     replicative senescence   AspGD NCBITaxon:75750 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
budA     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
AN11910     regulation of cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Afu1g09640     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus fumigatus IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
ACLA_015700     replicative senescence   AspGD Aspergillus clavatus NRRL 1 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090701001210     regulation of cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000004500   gene_product   AspGD_REF:ASPL0000000005 2E+07
Acar5010_174030     replicative senescence   AspGD NCBITaxon:602072 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090012000904     extrachromosomal circular DNA localization involved in cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000004311   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspve1_0212464     replicative senescence   AspGD NCBITaxon:46472 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspwe1_0058885     replicative senescence   AspGD NCBITaxon:1073089 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
tp53 tumor protein p53   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 cellular tumor antigen p53 pthr11447 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
tp53 tumor protein p53   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 cellular tumor antigen p53 pthr11447 protein_coding_gene   PMID:24967584 2E+07
ing2 inhibitor of growth family, member 2   regulation of cellular senescence   ZFIN Danio rerio IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein_coding_gene   ZFIN:ZDB-PUB-020724-1 2E+07
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-MRPHLNO-081229-2 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
spns1 spinster homolog 1 (Drosophila)   cellular senescence   ZFIN Danio rerio IMP ZFIN:ZDB-MRPHLNO-081229-2 spinster pthr23505 protein_coding_gene   PMID:24967584 2E+07
romo1 reactive oxygen species modulator 1   replicative senescence   UniProt Danio rerio ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
becn1 beclin 1, autophagy related   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-GENO-141104-6 beclin 1 pthr12768 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
becn1 beclin 1, autophagy related   cellular senescence   ZFIN Danio rerio IGI ZFIN:ZDB-MRPHLNO-081229-2 beclin 1 pthr12768 protein_coding_gene   PMID:24967584 2E+07
ZFIN:ZDB-MRPHLNO-141015-1
grnb granulin b   negative regulation of cell aging   ZFIN Danio rerio IGI ZFIN:ZDB-GENE-030131-7393 granulin pthr12274 protein_coding_gene   PMID:32028681 2E+07
march5l membrane-associated ring finger (C3HC4) 5, like   negative regulation of cell aging   UniProt Danio rerio ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
lmna lamin A   regulation of cell aging   ZFIN Danio rerio IMP ZFIN:ZDB-GENO-110523-6 lamin dm0-related pthr45721 protein_coding_gene   PMID:21479207 2E+07
ybx1 Y box binding protein 1   negative regulation of cellular senescence   UniProt Danio rerio ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein_coding_gene   ZFIN:ZDB-PUB-110105-1 2E+07
Map3k3 mitogen activated protein kinase kinase kinase 3   negative regulation of cellular senescence occurs inbone marrow cell RGD Rattus norvegicus ISO UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 gene   RGD:1624291 2E+07
ecrg4b ECRG4 augurin precursor b   cellular senescence   GO_Central Danio rerio IBA PANTHER:PTN002835855 augurin pthr31613 protein_coding_gene   PMID:21873635 2E+07
MGI:MGI:1926146
ecrg4a ECRG4 augurin precursor a   cellular senescence   GO_Central Danio rerio IBA PANTHER:PTN002835855 augurin pthr31613 protein_coding_gene   PMID:21873635 2E+07
MGI:MGI:1926146
Cdkn1a cyclin-dependent kinase inhibitor 1A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 gene   RGD:1624291 2E+07
Cdkn1a cyclin-dependent kinase inhibitor 1A   replicative senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 gene   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559 RGD:1600115
Morc3 MORC family CW-type zinc finger 3   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 gene   RGD:1624291 2E+07
Vash1 vasohibin 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 gene   RGD:1624291 2E+07
Npm1 nucleophosmin 1   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P06748 nucleoplasmin pthr22747 gene   GO_REF:0000024 2E+07
RGD:1600115
Npm1 nucleophosmin 1   cell aging   RGD Rattus norvegicus ISO UniProtKB:P06748 nucleoplasmin pthr22747 gene   RGD:1624291 2E+07
Bmpr1a bone morphogenetic protein receptor type 1A   regulation of cellular senescence regulates→occurs induct epithelial cell RGD Rattus norvegicus ISO MGI:1338938 transforming growth factor-beta receptor type i and ii pthr23255 gene   RGD:1624291 2E+07
Mir128-2 microRNA 128-2   cell aging   RGD Rattus norvegicus ISO MGI:3618709   gene   RGD:1624291 2E+07
Pml PML nuclear body scaffold   cell aging   RGD Rattus norvegicus ISO MGI:104662 bonus, isoform c-related pthr25462 gene   RGD:1624291 2E+07
Pml PML nuclear body scaffold   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P29590 bonus, isoform c-related pthr25462 gene   RGD:1624291 2E+07
Prelp proline and arginine rich end leucine rich repeat protein   cell aging   RGD Rattus norvegicus ISO MGI:2151110 agap008170-pa pthr45712 gene   RGD:1624291 2E+07
Mme membrane metallo-endopeptidase   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 gene   GO_REF:0000024 2E+07
RGD:1600115
Mme membrane metallo-endopeptidase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 gene   RGD:1624291 2E+07
Met MET proto-oncogene, receptor tyrosine kinase   cell aging   RGD Rattus norvegicus IEP   tyrosine-protein kinase receptor pthr24416 gene   PMID:18202313 2E+07
RGD:2317463
Mir15b microRNA 15b   cell aging   RGD Rattus norvegicus ISO MGI:2676842   gene   RGD:1624291 2E+07
Pawr pro-apoptotic WT1 regulator   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 gene UniProtKB:G3V6S1 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951 RGD:1600115
Pawr pro-apoptotic WT1 regulator   positive regulation of cellular senescence occurs infibroblast of cardiac tissue RGD Rattus norvegicus ISO MGI:2149961 prostate apoptosis response protein par-4 pthr15093 gene   RGD:1624291 2E+07
Mir125b1 microRNA 125b-1   cell aging   RGD Rattus norvegicus ISO MGI:2676810   gene   RGD:1624291 2E+07
Mir19b1 microRNA 19b-1   cell aging   RGD Rattus norvegicus ISO MGI:3629917   gene   RGD:1624291 2E+07
Mir34b microRNA 34b   cell aging   RGD Rattus norvegicus ISO MGI:3619364   gene   RGD:1624291 2E+07
Mir134 microRNA 134   cell aging   RGD Rattus norvegicus ISO MGI:2676819   gene   RGD:1624291 2E+07
Mir20a microRNA 20a   cell aging   RGD Rattus norvegicus ISO MGI:2676872   gene   RGD:1624291 2E+07
Tp63 tumor protein p63   cell aging occurs inEMAPA:17528 RGD Rattus norvegicus ISO MGI:1330810 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
occurs inkeratinocyte
Tp63 tumor protein p63   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9H3D4 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
UniProtKB:Q9H3D4-2
Bcl6 BCL6, transcription repressor   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:107187 zinc finger and btb domain-containing pthr24399 gene   RGD:1624291 2E+07
Mir23a microRNA 23a   cell aging   RGD Rattus norvegicus ISO MGI:2676897   gene   RGD:1624291 2E+07
Mir31 microRNA 31   cell aging   RGD Rattus norvegicus ISO MGI:3619330   gene   RGD:1624291 2E+07
Mir125a microRNA 125a   cell aging   RGD Rattus norvegicus ISO MGI:2676809   gene   RGD:1624291 2E+07
Mir130a microRNA 130a   cell aging   RGD Rattus norvegicus ISO MGI:2676816   gene   RGD:1624291 2E+07
Mir199a2 microRNA 199a-2   cell aging   RGD Rattus norvegicus ISO MGI:3618742   gene   RGD:1624291 2E+07
Mir370 microRNA 370   cell aging   RGD Rattus norvegicus ISO MGI:3619375   gene   RGD:1624291 2E+07
Mir140 microRNA 140   cell aging   RGD Rattus norvegicus ISO MGI:2676825   gene   RGD:1624291 2E+07
Mir24-2 microRNA 24-2   cell aging   RGD Rattus norvegicus ISO MGI:3618755   gene   RGD:1624291 2E+07
Mir296 microRNA 296   cell aging   RGD Rattus norvegicus ISO MGI:3619269   gene   RGD:1624291 2E+07
Nox4 NADPH oxidase 4   cell aging   UniProt Rattus norvegicus ISS UniProtKB:Q9JHI8 nadph oxidase pthr11972 gene   GO_REF:0000024 2E+07
RGD:1600115
Nox4 NADPH oxidase 4   cell aging   RGD Rattus norvegicus ISO MGI:1354184 nadph oxidase pthr11972 gene   RGD:1624291 2E+07
LOC100912427 nuclease-sensitive element-binding protein 1-like   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:99146   gene   RGD:1624291 2E+07
Serpine1 serpin family E member 1   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene   GO_REF:0000024 2E+07
RGD:1600115
Serpine1 serpin family E member 1   replicative senescence   Ensembl Rattus norvegicus IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene UniProtKB:F1LM16 GO_REF:0000107 2E+07
ensembl:ENSP00000223095 RGD:1600115
Serpine1 serpin family E member 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 gene   RGD:1624291 2E+07
Cdk6 cyclin-dependent kinase 6   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q00534 cell division protein kinase pthr24056 gene   RGD:1624291 2E+07
Mif macrophage migration inhibitory factor   cell aging   RGD Rattus norvegicus ISO MGI:96982 d-dopachrome decarboxylase pthr11954 gene   RGD:1624291 2E+07
Mif macrophage migration inhibitory factor   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 gene   RGD:1624291 2E+07
Wrn WRN RecQ like helicase   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q14191 dna helicase recq family member pthr13710 gene   RGD:1624291 2E+07
Wrn WRN RecQ like helicase   replicative senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:109635 dna helicase recq family member pthr13710 gene   RGD:1624291 2E+07
Mir27a microRNA 27a   cell aging   RGD Rattus norvegicus ISO MGI:2676902   gene   RGD:1624291 2E+07
Mir19b2 microRNA 19b-2   cell aging   RGD Rattus norvegicus ISO MGI:2676868   gene   RGD:1624291 2E+07
Plk2 polo-like kinase 2   negative regulation of cellular senescence occurs inadult endothelial progenitor cell RGD Rattus norvegicus ISO MGI:1099790 serine/threonine-protein kinase plk pthr24345 gene   RGD:1624291 2E+07
grna granulin a   negative regulation of cell aging   ZFIN Danio rerio IGI ZFIN:ZDB-GENE-030131-7393 granulin pthr12274 protein_coding_gene   PMID:32028681 2E+07
NAC6 NAC domain containing protein 6   stress-induced premature senescence   UniProt Arabidopsis thaliana IMP   protein cup-shaped cotyledon 2-related pthr31744 protein TAIR:locus:2164895 TAIR:Publication:501750682 2E+07
PMID:22930749
TFL1 TERMINAL FLOWER 1   negative regulation of cell aging   TAIR Arabidopsis thaliana IMP   phosphatidylethanolamine-binding protein pthr11362 protein TAIR:locus:2150595 TAIR:Publication:501732666 2E+07
PMID:18713382
ATB' GAMMA AT4G15415   regulation of cell aging   TAIR Arabidopsis thaliana IMP   serine/threonine protein phosphatase 2a pp2a regulatory subunit b pthr10257 protein TAIR:locus:505006470 TAIR:Publication:501742604 2E+07
PMID:21571669
GBF1 G-box binding factor 1   regulation of cell aging   TAIR Arabidopsis thaliana IMP   g-box-binding factor 3-related pthr45967 protein TAIR:locus:2115250 TAIR:Publication:501737893 2E+07
PMID:20484024
Abi3bp ABI family member 3 binding protein   positive regulation of cellular senescence part ofdefense response to tumor cell ARUK-UCL Rattus norvegicus ISS UniProtKB:Q9P2A4 tarsh-related fibronectin domain-containing pthr23197 gene   GO_REF:0000024 2E+07
RGD:1600115
MTOR Serine/threonine-protein kinase mTOR   cell aging   Ensembl Homo sapiens IEA UniProtKB:P42346 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000014167
ECRG4 Augurin   cellular senescence   GO_Central Homo sapiens IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
SLC30A10 Zinc transporter 10   negative regulation of cellular senescence   UniProt Homo sapiens IDA   fi23527p1 pthr45820 protein   PMID:22427991 2E+07
MAPK14 Mitogen-activated protein kinase 14   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
MAPK14 Mitogen-activated protein kinase 14   stress-induced premature senescence   BHF-UCL Homo sapiens IMP   mitogen-activated protein kinase pthr24055 protein   PMID:20160708 2E+07
CDKN2B Cyclin-dependent kinase 4 inhibitor B   cellular senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:17553787 2E+07
Cyclin-dependent kinase inhibitor 2A   cellular senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:16243918 2E+07  
CDKN2A Cyclin-dependent kinase inhibitor 2A   replicative senescence   BHF-UCL Homo sapiens IMP   family not named pthr24201 protein   PMID:14720514 2E+07
CDKN2A Cyclin-dependent kinase inhibitor 2A   positive regulation of cellular senescence   UniProt Homo sapiens IMP   family not named pthr24201 protein   PMID:16901784 2E+07
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Homo sapiens IMP   uncharacterized pthr21330 protein   PMID:17589526 2E+07
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
OPA1 Dynamin-like 120 kDa protein, mitochondrial   cellular senescence   UniProt Homo sapiens IDA   dynamin pthr11566 protein   PMID:17545159 2E+07
FOXM1 Forkhead box protein M1   negative regulation of cell aging   UniProt Homo sapiens IMP   forkhead box protein m1 pthr46878 protein   PMID:19696738 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Homo sapiens IMP   superoxide dismutase cu-zn -related pthr10003 protein   PMID:12871978 2E+07
DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99M87 dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053842
FZR1 Fizzy-related protein homolog   negative regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
PRMT6 Protein arginine N-methyltransferase 6   cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000140836
ICAM1 Intercellular adhesion molecule 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q00238 intercellular adhesion molecule pthr13771 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000028066
NUAK1 NUAK family SNF1-like kinase 1   regulation of cellular senescence   UniProt Homo sapiens IDA   serine/threonine kinase pthr24343 protein   PMID:19927127 2E+07
SPI1 Transcription factor PU.1   oncogene-induced cell senescence occurs infibroblast ARUK-UCL Homo sapiens ISS UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000024 2E+07
occurs inhematopoietic stem cellmore...
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Homo sapiens IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
ZMPSTE24 CAAX prenyl protease 1 homolog   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   cell aging   BHF-UCL Homo sapiens TAS   histone deacetylase sir2 family member pthr11085 protein   PMID:11672523 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   stress-induced premature senescence   CACAO Homo sapiens IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:17916362 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   negative regulation of cellular senescence   UniProt Homo sapiens IDA   histone deacetylase sir2 family member pthr11085 protein   PMID:20203304 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:20424141 2E+07
SIRT1 NAD-dependent protein deacetylase sirtuin-1   positive regulation of cellular senescence   UniProt Homo sapiens IDA   histone deacetylase sir2 family member pthr11085 protein   PMID:18687677 2E+07
EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1   positive regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA   eukaryotic translation elongation factor 1 epsilon-1 pthr44490 protein   PMID:25465621 2E+07
ATM Serine-protein kinase ATM   cellular senescence   Reactome Homo sapiens TAS   ataxia telangiectasia mutated atm -related pthr11139 protein   Reactome:R-HSA-2559583 2E+07
ATM Serine-protein kinase ATM   replicative senescence   BHF-UCL Homo sapiens IMP   ataxia telangiectasia mutated atm -related pthr11139 protein   PMID:15149599 2E+07
NUP62 Nuclear pore glycoprotein p62   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
TP63 Tumor protein 63   cell aging   Ensembl Homo sapiens IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
ZMIZ1 Zinc finger MIZ domain-containing protein 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
ABI3 ABI gene family member 3   positive regulation of cellular senescence part ofdefense response to tumor cell ARUK-UCL Homo sapiens IMP   abl interactor family member pthr10460 protein   PMID:21223585 2E+07
HMGA2 High mobility group protein HMGI-C   oncogene-induced cell senescence   UniProt Homo sapiens IDA   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
HMGA2 High mobility group protein HMGI-C   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens ISS UniProtKB:P52927 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA2 High mobility group protein HMGI-C   positive regulation of cellular senescence   UniProt Homo sapiens IMP   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
CALR Calreticulin   cellular senescence   BHF-UCL Homo sapiens IGI ENSEMBL_GeneID:ENSG00000124762 calreticulin and calnexin pthr11073 protein   PMID:14726956 2E+07
ING2 Inhibitor of growth protein 2   regulation of cellular senescence   BHF-UCL Homo sapiens NAS   inhibitor of growth protein pthr10333 protein   PMID:21124965 2E+07
PAWR PRKC apoptosis WT1 regulator protein   positive regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Homo sapiens IMP   mannose, phospholipase, lectin receptor related pthr22803 protein   PMID:19197340 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Homo sapiens IMP   mannose, phospholipase, lectin receptor related pthr22803 protein   PMID:19197340 2E+07
ABL1 Tyrosine-protein kinase ABL1   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
SMC6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Homo sapiens IMP   structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   PMID:17589526 2E+07
TBX2 T-box transcription factor TBX2   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11748239 2E+07
TBX2 T-box transcription factor TBX2   cellular senescence   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:22002537 2E+07
ULK3 Serine/threonine-protein kinase ULK3   cellular senescence   UniProt Homo sapiens TAS   serine/threonine-protein kinase unc-51-related pthr24348 protein   PMID:19279323 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Homo sapiens IMP   serine protease inhibitor, serpin pthr11461 protein   PMID:16862142 2E+07
  Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:22002537 2E+07
PML Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:22117195 2E+07
PML Protein PML   cellular senescence   UniProt Homo sapiens IDA   bonus, isoform c-related pthr25462 protein   PMID:23431171 2E+07
WNT16 Protein Wnt-16   replicative senescence   BHF-UCL Homo sapiens IMP   wnt related pthr12027 protein   PMID:19951988 2E+07
WNT16 Protein Wnt-16   oxidative stress-induced premature senescence   BHF-UCL Homo sapiens IMP   wnt related pthr12027 protein   PMID:19951988 2E+07
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9Y243   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MME Atriopeptidase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P08473   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence occurs inaortic endothelial cell AgBase Sus scrofa IMP   histone deacetylase sir2 family member pthr11085 protein   PMID:20203304 2E+07
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
PRELP LRRNT domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
MIF Macrophage migration inhibitory factor   cell aging   Ensembl Sus scrofa IEA UniProtKB:P34884 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000041149
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000215754
LMNA Lamin isoform A   positive regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P02545   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
P14ARF ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
P14ARF ANK_REP_REGION domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
P14ARF ANK_REP_REGION domain-containing protein   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42771 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000307101
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase dsor1-like protein pthr47448 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Sus scrofa IEA UniProtKB:O88898   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   Ensembl Sus scrofa IEA UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
MNT BHLH domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q8IW41   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
CDKN2B ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P42772 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000276925
MARCHF5 Membrane associated ring-CH-type finger 5   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P51957   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
BCL2L12 BCL2 like 12   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9D3J3 family not named pthr14965 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003290
CALR Calreticulin   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
WRN DNA helicase   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q14191 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000298139
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Sus scrofa ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
FBXO5 F-box domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
CDKN1A CDI domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000244741
CDKN1A CDI domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
RSL1D1 Ribosomal L1 domain containing 1   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O76021   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
STK11 Non-specific serine/threonine protein kinase   positive regulation of cellular senescence occurs inaortic endothelial cell AgBase Sus scrofa IMP   family not named pthr43895 protein   PMID:20203304 2E+07
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P60602   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
TERF2 HTH myb-type domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
SPI1 ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Sus scrofa IEA UniProtKB:P17433   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000002180
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q08050   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P28749   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
BCL6 B-cell CLL/lymphoma 6   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
PAWR Pro-apoptotic WT1 regulator   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
TP53 Cellular tumor antigen p53   cell aging   UniProt Sus scrofa ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
PRMT6 Methyltransf_25 domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000140836
Inhibitor of growth protein   regulation of cellular senescence   InterPro Sus scrofa IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07  
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:E9Q6D6   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q53EL6   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
SERPINE1 SERPIN domain-containing protein   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000223095
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q13018   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q13018   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
NUP62 Nsp1_C domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
PRKCD Protein kinase C   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q05655   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:O60313   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
YPEL3 Protein yippee-like   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P61236   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
WNT16 Protein Wnt   replicative senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Sus scrofa IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
PML PML nuclear body scaffold   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Sus scrofa IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
NPM1 Nucleophosmin   cell aging   Ensembl Sus scrofa IEA UniProtKB:P06748   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000296930
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P78540 arginase pthr43782 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
HLA-G HLA class I histocompatibility antigen, alpha chain G   positive regulation of cellular senescence   UniProt Homo sapiens IDA   mhc class i-related pthr16675 protein   PMID:23184984 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Homo sapiens IDA   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Homo sapiens IMP   high mobility group proteins hmg-a and c pthr23341 protein   PMID:16901784 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
URS000075AC88_9823 Sus scrofa (pig) microRNA ssc-mir-342 precursor   cell aging   RNAcentral Sus scrofa IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000A95B56_9823 Sus scrofa (pig) microRNA ssc-mir-370 precursor   cell aging   RNAcentral Sus scrofa IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Sus scrofa ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000024 2E+07
MAPK14 Mitogen-activated protein kinase 14   stress-induced premature senescence   Ensembl Sus scrofa IEA UniProtKB:Q16539   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229794
URS000071B780_9606 Homo sapiens (human) microRNA hsa-mir-342 precursor   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000EFD26A_9606 Homo sapiens (human) Hsa-Mir-342 stem-loop   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000039ED8D_9606 Homo sapiens (human) hsa-miR-21-5p   positive regulation of replicative senescence regulates→occurs inendothelial cell BHF-UCL Homo sapiens IDA     miRNA   PMID:23496142 2E+07
URS0000272039_9606 Homo sapiens (human) hsa-miR-590-3p   negative regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25465621 2E+07
URS00007281EA_9606 Homo sapiens microRNA mir-370   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS000030BD69_9606 Homo sapiens (human) hsa-miR-34a-5p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IDA     miRNA   PMID:20424141 2E+07
URS000019F055_9606 Homo sapiens (human) hsa-miR-543   negative regulation of cellular senescence occurs inmesenchymal stem cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25465621 2E+07
URS000041E210_9606 Homo sapiens (human) hsa-miR-217-5p   positive regulation of cellular senescence occurs inblood vessel endothelial cell BHF-UCL Homo sapiens IMP     miRNA   PMID:19786632 2E+07
URS000075B235_9606 Homo sapiens (human) microRNA hsa-mir-370 precursor   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS00004416C5_9606 Homo sapiens (human) telomerase RNA component   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     telomerase_RNA   PMID:11313459 2E+07
URS00002B3783_9606 Homo sapiens (human) hsa-miR-20b-5p   positive regulation of cellular senescence occurs inmicrovascular endothelial cell BHF-UCL Homo sapiens IMP     miRNA   PMID:28595801 2E+07
URS000050B527_9606 Homo sapiens (human) hsa-miR-146a-5p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens ISS RNAcentral:URS000050B527_10090   miRNA   GO_REF:0000024 2E+07
URS0000EFE467_9606 Homo sapiens (human) Hsa-Mir-370 stem-loop   cell aging   RNAcentral Homo sapiens IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS0000083D87_9606 Homo sapiens (human) hsa-miR-188-5p   positive regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens IDA     miRNA   PMID:28640956 2E+07
tert-terc_human Telomerase catalytic core complex   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     protein_complex   PMID:11313459 2E+07
abeta-42-oligomer_human Amyloid-beta protein 42 oligomeric complex   positive regulation of cellular senescence regulates→occurs inmicroglial cell ARUK-UCL Homo sapiens IDA     protein_complex   PMID:28912710 2E+07
URS0000096022_9606 Homo sapiens (human) hsa-miR-22-3p   positive regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IDA     miRNA   PMID:25323119 2E+07
URS00004A7003_9606 Homo sapiens telomerase RNA component (TERC)   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP     telomerase_RNA   PMID:11313459 2E+07
AKT3 RAC-gamma serine/threonine-protein kinase   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Homo sapiens IMP   serine/threonine-protein kinase pthr24356 protein   PMID:25323119 2E+07
FBXO5 F-box only protein 5   negative regulation of cellular senescence   UniProt Homo sapiens IMP   f-box only protein 5 and 43 pthr15493 protein   PMID:17875940 2E+07
MORC3 CW-type domain-containing protein   cell aging   Ensembl Sus scrofa IEA UniProtKB:Q14149   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
YBX1 CSD domain-containing protein   negative regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P62960   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589
PLA2R1 Uncharacterized protein   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
PLA2R1 Uncharacterized protein   oxidative stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000283243
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
B2M Beta-2-microglobulin   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P61769 mhc class ii-related pthr19944 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000497910
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
MIF Macrophage migration inhibitory factor   cell aging   Ensembl Gallus gallus IEA UniProtKB:P34884 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000041149
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000215754
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
PAWR Uncharacterized protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
HRAS GTPase HRas   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309845
SLC30A10 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355893
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
BCL6 B-cell lymphoma 6 protein homolog   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P41183 ip01015p-related pthr24377 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P78540 arginase pthr43782 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
MME Atriopeptidase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Gallus gallus IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
SPI1 ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Gallus gallus IEA UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000002180
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
cdk6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Gallus gallus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
MAPK14 Mitogen-activated protein kinase   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229794
MAP3K3 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
HMGA1 High mobility group A1b   oncogene-induced cell senescence   UniProt Gallus gallus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA1 High mobility group A1b   positive regulation of cellular senescence   UniProt Gallus gallus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Gallus gallus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
ABI3 Abi_HHR domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
DNAJA3 Uncharacterized protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q99M87 dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053842
5-Mar RING-CH-type domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
VASH1 Uncharacterized protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9Y243 ribosomal protein s6 kinase pthr24351 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MORC4 CW-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96MF7 uncharacterized pthr21330 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Gallus gallus ISS UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   GO_REF:0000024 2E+07
LOC396224 IF rod domain-containing protein   positive regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P02545 lamin dm0-related pthr45721 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
ZNF277 C2H2-type domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
WNT16 Protein Wnt   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
TBX domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O15119   protein   GO_REF:0000107 2E+07  
ensembl:ENSP00000257567  
RWDD1 RWD domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9CQK7 rwd domain-containing protein pthr12292 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000019917
HMGI-C High mobility group protein I-C   oncogene-induced cell senescence   Ensembl Gallus gallus IEA UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000384026
HMGI-C High mobility group protein I-C   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000384026
MB21D1 Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Gallus gallus IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Gallus gallus ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000024 2E+07
RBL1 Uncharacterized protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
B9J08_002050     regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
ERCC1 DNA excision repair protein ERCC-1   replicative senescence   Ensembl Bos taurus IEA UniProtKB:P07903 excision repair cross-complementing 1 ercc1 pthr12749 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003645
HMGA2 High mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Bos taurus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA2 High mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Bos taurus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
TP53 Cellular tumor antigen p53   cell aging   UniProt Bos taurus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   Ensembl Bos taurus IEA UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 protein   GO_REF:0000024 2E+07
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
BCL6 BCL6 transcription repressor   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q6P1E1 zinc finger miz domain-containing protein pthr10782 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Bos taurus ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Bos taurus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Bos taurus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
SIRT1 Deacetylase sirtuin-type domain-containing protein   stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
SIRT1 Deacetylase sirtuin-type domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000212015
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
CDKN1A CDI domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000244741
CDKN1A CDI domain-containing protein   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
BCL2L12 BCL2 like 12   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9D3J3 family not named pthr14965 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003290
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Bos taurus IEA UniProtKB:P10417 bcl-2 related pthr11256 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Bos taurus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Bos taurus ISS UniProtKB:Q96MF7 uncharacterized pthr21330 protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Bos taurus ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:Q9R1K5 cell division cycle 20 cdc20 fizzy -related pthr19918 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P78540   protein   GO_REF:0000107 2E+07
 
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
BRCA2 Tower domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
TWIST1 BHLH domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000242261
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
CGAS Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q5SUQ9 cst complex subunit ctc1 pthr14865 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
PRELP LRRNT domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q9JK53 ig(immunoglobulin) and lrr(leucine rich repeat) domains pthr24366 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Gallus gallus IEA UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Gallus gallus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
ROMO1 Reactive oxygen species modulator 1   replicative senescence   UniProt Bos taurus ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
PLK2 Serine/threonine-protein kinase PLK   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
NOX4 FAD-binding FR-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000070039
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Bos taurus ISS UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000024 2E+07
TERF2 HTH myb-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
PML PML nuclear body scaffold   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
PAWR Uncharacterized protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q925B0 prostate apoptosis response protein par-4 pthr15093 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000092951
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
ZMPSTE24 CAAX prenyl protease   regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
NUP62 Nsp1_C domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q63850 nuclear pore glycoprotein p62-related pthr12084 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000056785
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Bos taurus IEA UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
WNT16 Protein Wnt   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
LMNA Lamin A/C   positive regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P02545 lamin dm0-related pthr45721 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
YPEL3 Protein yippee-like   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
SLC30A10 Solute carrier family 30 member 10   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355893
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Bos taurus ISS UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000024 2E+07
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
WNT1 Protein Wnt   negative regulation of cell aging   Ensembl Bos taurus IEA UniProtKB:P04628 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000293549
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Bos taurus IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Bos taurus IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
ABI3 SH3 domain-containing protein   positive regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354957
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
CALR Calreticulin   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Bos taurus IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PRELP LRRNT domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
CDKN2B ANK_REP_REGION domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P42772 family not named pthr24201 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000276925
SOD1 Sod_Cu domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
CALR Calreticulin   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P14211   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P27797   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Canis lupus familiaris ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Canis lupus familiaris ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000024 2E+07
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q5SUQ9   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
ETS domain-containing protein   oncogene-induced cell senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17433 ets pthr11849 protein   GO_REF:0000107 2E+07  
ensembl:ENSMUSP00000002180  
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000354485
ensembl:ENSP00000354927
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
VASH1 Vasohibin 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q7L8A9   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000167106
ROMO1 Protein MGR2 homolog   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P60602   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000363190
TERT Telomerase reverse transcriptase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O14746   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O14746   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000309572
MAP2K1 Protein kinase domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q02750   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000302486
MARCHF5 RING-CH-type domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000351813
FOXM1 Fork-head domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000352901
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
BCL6 B-cell lymphoma 6 protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P41183   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
PLK2 Polo kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P53351   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
MAPKAPK5 Protein kinase domain-containing protein   stress-induced premature senescence   Ensembl Bos taurus IEA UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000449667
WRN DNA helicase   replicative senescence   Ensembl Bos taurus IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
CDK6 Protein kinase domain-containing protein   negative regulation of cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q00534 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000397087
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Bos taurus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
MORC3 CW-type domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Bos taurus ISS UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000024 2E+07
MNT BHLH domain-containing protein   cell aging   Ensembl Bos taurus IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
URS0000EFF4B3_9913 Bos taurus (cattle) Bta-Mir-342 stem-loop   cell aging   RNAcentral Bos taurus IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000075E3EC_9913 Bos taurus (cattle) microRNA bta-mir-370 precursor   cell aging   RNAcentral Bos taurus IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS000075C963_9913 Bos taurus (cattle) microRNA bta-mir-342 precursor   cell aging   RNAcentral Bos taurus IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS0000EFBD9D_9913 Bos taurus (cattle) Bta-Mir-370 stem-loop   cell aging   RNAcentral Bos taurus IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
WRN DNA helicase   replicative senescence   Ensembl Gallus gallus IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
NUAK1 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O60285 serine/threonine kinase pthr24343 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261402
SMC6 SMC_N domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
TWIST1 BHLH domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000242261
NPM1 Nucleophosmin   cell aging   UniProt Gallus gallus ISS UniProtKB:P06748 nucleoplasmin pthr22747 protein   GO_REF:0000024 2E+07
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   AgBase Gallus gallus ISA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   PMID:16307863 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   Ensembl Gallus gallus IEA UniProtKB:P00441   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000270142
CALR Calreticulin   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P14211 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003912
CALR Calreticulin   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000320866
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Gallus gallus IEA UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P11831   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
RSL1D1 Uncharacterized protein   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
C1H2ORF40 Uncharacterized protein   cellular senescence   GO_Central Gallus gallus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
TBX3 T-box transcription factor TBX3   cell aging   UniProt Gallus gallus ISS UniProtKB:O15119 t-box protein-related pthr11267 protein   GO_REF:0000024 2E+07
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   MGI Mus musculus ISO UniProtKB:O60313 dynamin pthr11566 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Foxm1 forkhead box M1   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:Q08050 forkhead box protein m1 pthr46878 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pla2r1 phospholipase A2 receptor 1   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Morc3 microrchidia 3   cell aging   MGI Mus musculus ISO UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   MGI:MGI:3763815 2E+07
PMID:17332504
Trp63 transformation related protein 63   cell aging occurs inEMAPA:17528 MGI Mus musculus IMP MGI:MGI:2385473 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:3588617 2E+07
occurs inkeratinocyte PMID:16107615
Trp63 transformation related protein 63   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9H3D4 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Arg2 arginase type II   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P78540 arginase pthr43782 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zfp217 zinc finger protein 217   cell aging   MGI Mus musculus ISO EMBL:AF041259 zinc finger protein pthr45925 protein   MGI:MGI:2154458 2E+07
GO_REF:0000008
Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2183945 excision repair cross-complementing 1 ercc1 pthr12749 protein   MGI:MGI:893240 2E+07
PMID:9197240
Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2183944 excision repair cross-complementing 1 ercc1 pthr12749 protein   MGI:MGI:3699021 2E+07
PMID:17173483
Sod1 superoxide dismutase 1, soluble   cell aging   MGI Mus musculus ISO UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Id2 inhibitor of DNA binding 2   cellular senescence   UniProt Mus musculus IMP   dna-binding protein inhibitor pthr11723 protein   MGI:MGI:4412240 2E+07
PMID:18474814
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   MGI Mus musculus ISO UniProtKB:Q96MF7 uncharacterized pthr21330 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hras Harvey rat sarcoma virus oncogene   cell aging   MGI Mus musculus IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:2670239 2E+07
PMID:12878730
Hras Harvey rat sarcoma virus oncogene   cell aging   MGI Mus musculus IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Hras Harvey rat sarcoma virus oncogene   cellular senescence   MGI Mus musculus ISO UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hras Harvey rat sarcoma virus oncogene   cellular senescence   GO_Central Mus musculus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
Prmt6 protein arginine N-methyltransferase 6   cellular senescence   MGI Mus musculus IMP   protein arginine n-methyltransferase pthr11006 protein   MGI:MGI:5504576 2E+07
PMID:22904064
Prkdc protein kinase, DNA activated, catalytic polypeptide   negative regulation of cellular senescence   MGI Mus musculus ISO RGD:1308982 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cell aging   MGI Mus musculus IDA     protein   MGI:MGI:2159048 2E+07
PMID:11748239
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence occurs inosteoblast MGI Mus musculus IDA     protein   MGI:MGI:5449665 2E+07
occurs inosteoblast PMID:22729085
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus ISO UniProtKB:Q8N726   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   cellular senescence   MGI Mus musculus IMP     protein   MGI:MGI:5299398 2E+07
PMID:21911473
Cdkn2a cyclin dependent kinase inhibitor 2A   replicative senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2a cyclin dependent kinase inhibitor 2A   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P42771   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cdkn2b cyclin dependent kinase inhibitor 2B   cellular senescence   MGI Mus musculus ISO UniProtKB:P42772 family not named pthr24201 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pml promyelocytic leukemia   cell aging   UniProt Mus musculus IMP   bonus, isoform c-related pthr25462 protein   MGI:MGI:3717518 2E+07
PMID:10910364
Pml promyelocytic leukemia   cellular senescence   MGI Mus musculus ISO UniProtKB:P29590 bonus, isoform c-related pthr25462 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Kras Kirsten rat sarcoma viral oncogene homolog   positive regulation of cellular senescence   MGI Mus musculus ISO RGD:2981 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Xrn1 5'-3' exoribonuclease 1   cell aging   UniProt Mus musculus NAS   5'->3' exoribonuclease pthr12341 protein   MGI:MGI:893338 2E+07
PMID:9218715
Ecrg4 ECRG4 augurin precursor   cellular senescence   MGI Mus musculus IDA   augurin pthr31613 protein   MGI:MGI:4454240 2E+07
PMID:20404145
Ecrg4 ECRG4 augurin precursor   cellular senescence   GO_Central Mus musculus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
Atr ataxia telangiectasia and Rad3 related   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Smc5 structural maintenance of chromosomes 5   cellular senescence   MGI Mus musculus ISO UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor)   cell aging   MGI Mus musculus IMP MGI:MGI:2673280 d-dopachrome decarboxylase pthr11954 protein   MGI:MGI:2670239 2E+07
PMID:12878730
Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor)   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:P14174 d-dopachrome decarboxylase pthr11954 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1888594 caax prenyl protease 1 pthr10120 protein   MGI:MGI:5500993 2E+07
PMID:23686339
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2180033 caax prenyl protease 1 pthr10120 protein   MGI:MGI:3789238 2E+07
PMID:16079796
Zmpste24 zinc metallopeptidase, STE24   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2180033 caax prenyl protease 1 pthr10120 protein   MGI:MGI:5139938 2E+07
PMID:21746928
Ing2 inhibitor of growth family, member 2   regulation of cellular senescence   UniProt Mus musculus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   MGI:MGI:2152098 2E+07
GO_REF:0000002
Fzr1 fizzy and cell division cycle 20 related 1   negative regulation of cell aging   BHF-UCL Mus musculus IMP   cell division cycle 20 cdc20 fizzy -related pthr19918 protein   MGI:MGI:5009768 2E+07
PMID:21241890
Prelp proline arginine-rich end leucine-rich repeat   cell aging   MGI Mus musculus IDA   agap008170-pa pthr45712 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Mir378a microRNA 378a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21)   cellular senescence   MGI Mus musculus ISO UniProtKB:P38936 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tp53 tumor protein p53   cell aging   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   GO_REF:0000024 2E+07
RGD:1600115
Tp53 tumor protein p53   cell aging   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   positive regulation of cell aging   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Tp53 tumor protein p53   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:98834 cellular tumor antigen p53 pthr11447 gene   RGD:1624291 2E+07
Pla2r1 phospholipase A2 receptor 1   replicative senescence   UniProt Rattus norvegicus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   GO_REF:0000024 2E+07
RGD:1600115
Pla2r1 phospholipase A2 receptor 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   RGD:1624291 2E+07
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Rattus norvegicus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   GO_REF:0000024 2E+07
RGD:1600115
Pla2r1 phospholipase A2 receptor 1   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 gene   RGD:1624291 2E+07
Nup62 nucleoporin 62   cell aging   RGD Rattus norvegicus ISO MGI:1351500 nuclear pore glycoprotein p62-related pthr12084 gene   RGD:1624291 2E+07
Mapkapk5 MAPK activated protein kinase 5   stress-induced premature senescence   RGD Rattus norvegicus ISO MGI:1333110 serine/threonine-protein kinase pthr24349 gene   RGD:1624291 2E+07
Mapkapk5 MAPK activated protein kinase 5   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 gene   RGD:1624291 2E+07
Mir483 microRNA 483   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
microRNA 5100   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07  
PMID:25751060  
H2ax H2A.X variant histone   cellular senescence   RGD Rattus norvegicus IEP   histone h2a pthr23430 gene   PMID:19946210 2E+07
RGD:8693719
Nuak1 NUAK family kinase 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O60285 serine/threonine kinase pthr24343 gene   RGD:1624291 2E+07
Kat6a lysine acetyltransferase 6A   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q92794 histone acetyltransferase pthr10615 gene   GO_REF:0000024 2E+07
RGD:1600115
Kat6a lysine acetyltransferase 6A   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 gene UniProtKB:A0A0A0MY12 GO_REF:0000107 2E+07
ensembl:ENSP00000265713 RGD:1600115
Kat6a lysine acetyltransferase 6A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q92794 histone acetyltransferase pthr10615 gene   RGD:1624291 2E+07
Cgas cyclic GMP-AMP synthase   positive regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:2442261   gene   RGD:1624291 2E+07
Prmt6 protein arginine methyltransferase 6   cellular senescence   RGD Rattus norvegicus ISO MGI:2139971 protein arginine n-methyltransferase pthr11006 gene   RGD:1624291 2E+07
Mirlet7d microRNA let-7d   cell aging   RGD Rattus norvegicus ISO MGI:2676796   gene   RGD:1624291 2E+07
Mir342 microRNA 342   cell aging   RGD Rattus norvegicus ISO MGI:3619358   gene   RGD:1624291 2E+07
Mirlet7b microRNA let-7b   cell aging   RGD Rattus norvegicus ISO MGI:2676794   gene   RGD:1624291 2E+07
Mirlet7f2 microRNA let-7f-2   cell aging   RGD Rattus norvegicus ISO MGI:2676799   gene   RGD:1624291 2E+07
Mirlet7i microRNA let-7i   cell aging   RGD Rattus norvegicus ISO MGI:2676802   gene   RGD:1624291 2E+07
Ypel3 yippee-like 3   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 gene   RGD:1624291 2E+07
Mir22 microRNA 22   cell aging   RGD Rattus norvegicus ISO MGI:2676896   gene   RGD:1624291 2E+07
Mir23b microRNA 23b   cell aging   RGD Rattus norvegicus ISO MGI:2676898   gene   RGD:1624291 2E+07
Mir25 microRNA 25   cell aging   RGD Rattus norvegicus ISO MGI:3619266   gene   RGD:1624291 2E+07
Mir30a microRNA 30a   cell aging   RGD Rattus norvegicus ISO MGI:2676907   gene   RGD:1624291 2E+07
Mir34c microRNA 34c   cell aging   RGD Rattus norvegicus ISO MGI:3619365   gene   RGD:1624291 2E+07
Mir34a microRNA 34a   cell aging   RGD Rattus norvegicus ISO MGI:3619363   gene   RGD:1624291 2E+07
Mir99a microRNA 99a   cell aging   RGD Rattus norvegicus ISO MGI:2676912   gene   RGD:1624291 2E+07
Mir125b2 microRNA 125b-2   cell aging   RGD Rattus norvegicus ISO MGI:3618706   gene   RGD:1624291 2E+07
Mir128-1 microRNA 128-1   cell aging   RGD Rattus norvegicus ISO MGI:2676813   gene   RGD:1624291 2E+07
Mir132 microRNA 132   cell aging   RGD Rattus norvegicus ISO MGI:2676817   gene   RGD:1624291 2E+07
Rbl1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Slc30a10 solute carrier family 30, member 10   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q6XR72 fi23527p1 pthr45820 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zfp277 zinc finger protein 277   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:5496522 zinc finger protein 277 pthr13267 protein   MGI:MGI:5496352 2E+07
PMID:20808772
Lmna lamin A   positive regulation of cell aging   MGI Mus musculus ISO UniProtKB:P02545 lamin dm0-related pthr45721 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pnpt1 polyribonucleotide nucleotidyltransferase 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Zmiz1 zinc finger, MIZ-type containing 1   cell aging   MGI Mus musculus IDA   zinc finger miz domain-containing protein pthr10782 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Sirt1 sirtuin 1   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Sirt1 sirtuin 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Sirt1 sirtuin 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Atm ataxia telangiectasia mutated   replicative senescence   MGI Mus musculus ISO UniProtKB:Q13315 ataxia telangiectasia mutated atm -related pthr11139 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Bcl6 B cell leukemia/lymphoma 6   negative regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2158436 zinc finger and btb domain-containing pthr24399 protein   MGI:MGI:5469797 2E+07
PMID:23209284
Htt huntingtin   cell aging   MGI Mus musculus IMP MGI:MGI:3603606 huntington disease protein pthr10170 protein   MGI:MGI:3619488 2E+07
PMID:16403806
Marchf5 membrane associated ring-CH-type finger 5   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Nek4 NIMA (never in mitosis gene a)-related expressed kinase 4   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1b high mobility group AT-hook 1B   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P17096   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1b high mobility group AT-hook 1B   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P17096   protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Nup62 nucleoporin 62   cell aging   MGI Mus musculus IDA   nuclear pore glycoprotein p62-related pthr12084 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Ybx1 Y box protein 1   negative regulation of cellular senescence   UniProt Mus musculus IMP   cold shock domain containing proteins pthr11544 protein   MGI:MGI:6158172 2E+07
PMID:29712925
Nox4 NADPH oxidase 4   cell aging   UniProt Mus musculus IMP   nadph oxidase pthr11972 protein   MGI:MGI:3694159 2E+07
PMID:10869423
Bmpr1a bone morphogenetic protein receptor, type 1A   regulation of cellular senescence regulates→occurs induct epithelial cell MGI Mus musculus IGI MGI:MGI:87859 transforming growth factor-beta receptor type i and ii pthr23255 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Bcl2l12 BCL2-like 12 (proline rich)   negative regulation of cellular senescence   MGI Mus musculus IDA   family not named pthr14965 protein   MGI:MGI:4834958 2E+07
PMID:20837658
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Pongo abelii ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Pongo abelii ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Oryctolagus cuniculus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Delphinapterus leucas ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   replicative senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Secretory phospholipase A2 receptor   oxidative stress-induced premature senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Cricetulus griseus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Neprilysin   replicative senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PLA2R1 Uncharacterized protein   replicative senescence   UniProt Nomascus leucogenys ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Uncharacterized protein   oxidative stress-induced premature senescence   UniProt Nomascus leucogenys ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
marchf5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Xenopus laevis ISS UniProtKB:Q9NX47   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca fuscata fuscata ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Callithrix jacchus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Equus caballus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Equus caballus ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
P89002 Cellular tumor antigen p53   cell aging   UniProt Mastomys natalensis ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Equus caballus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Equus caballus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
PLA2R1 C-type lectin domain-containing protein   replicative senescence   UniProt Macaca mulatta ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 C-type lectin domain-containing protein   oxidative stress-induced premature senescence   UniProt Macaca mulatta ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Loxodonta africana ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
URS00004636A3_9606 Homo sapiens (human) hsa-miR-17-3p   negative regulation of cellular senescence occurs infibroblast of cardiac tissue BHF-UCL Homo sapiens ISS RNAcentral:URS00001D3129_10090   miRNA   GO_REF:0000024 2E+07
occurs inembryonic fibroblast
URS00002F4762_9606 Homo sapiens (human) hsa-miR-10a-3p   positive regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens ISS RNAcentral:URS00002F4762_10090   miRNA   GO_REF:0000024 2E+07
URS0000EFBA16_9615 Canis lupus familiaris (dog) Cfa-Mir-342 stem-loop   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
MNT BHLH domain-containing protein   cell aging   Ensembl Gallus gallus IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
Mir183 microRNA 183   cell aging   RGD Rattus norvegicus ISO MGI:2676847   gene   RGD:1624291 2E+07
Top2b DNA topoisomerase II beta   cell aging   RGD Rattus norvegicus IDA     gene   PMID:20708677 2E+07
RGD:13432149
Mir191 microRNA 191   cell aging   RGD Rattus norvegicus ISO MGI:2676855   gene   RGD:1624291 2E+07
Mir211 microRNA 211   cell aging   RGD Rattus norvegicus ISO MGI:2676887   gene   RGD:1624291 2E+07
Tert telomerase reverse transcriptase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 gene   RGD:1624291 2E+07
Tert telomerase reverse transcriptase   negative regulation of cellular senescence occurs invascular associated smooth muscle cell RGD Rattus norvegicus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 gene   RGD:1624291 2E+07
part ofcellular response to hypoxia
Mapk14 mitogen activated protein kinase 14   stress-induced premature senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 gene UniProtKB:Q56A33 GO_REF:0000107 2E+07
ensembl:ENSP00000229794 RGD:1600115
Mapk14 mitogen activated protein kinase 14   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 gene   RGD:1624291 2E+07
Mir877 microRNA 877   cell aging   RGD Rattus norvegicus ISO MGI:3718567   gene   RGD:1624291 2E+07
Mir188 microRNA 188   cell aging   RGD Rattus norvegicus ISO MGI:2676852   gene   RGD:1624291 2E+07
Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:87859 tyrosine-protein kinase pthr24418 gene   RGD:1624291 2E+07
Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase   negative regulation of cellular senescence regulates→occurs inosteoblast RGD Rattus norvegicus ISO MGI:87859 tyrosine-protein kinase pthr24418 gene   RGD:1624291 2E+07
Srf serum response factor   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P11831 serum response factor homolog pthr48019 gene   RGD:1624291 2E+07
Mir671 microRNA 671   cell aging   RGD Rattus norvegicus ISO MGI:3629656   gene   RGD:1624291 2E+07
Fbxo5 F-box protein 5   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 gene   RGD:1624291 2E+07
Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10   cell aging   RGD Rattus norvegicus IEP   short-chain dehydrogenase/reductase pthr43658 gene   PMID:12810569 2E+07
RGD:2302236
Pnpt1 polyribonucleotide nucleotidyltransferase 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 gene   RGD:1624291 2E+07
Nuak1 NUAK family, SNF1-like kinase, 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O60285 serine/threonine kinase pthr24343 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir1897 microRNA 1897   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
ILK Integrin-linked protein kinase   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99J82 serine/threonine-protein kinase tnni3k-related pthr44329 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000025906
YPEL3 Protein yippee-like 3   positive regulation of cellular senescence   HGNC Homo sapiens IDA   protein yippee-like cg15309-related pthr13848 protein   PMID:20388804 2E+07
BRCA2 Breast cancer type 2 susceptibility protein   cell aging   Ensembl Homo sapiens IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
H2AX Histone H2AX   cellular senescence   Ensembl Homo sapiens IEA UniProtKB:D3ZXP3 histone h2a pthr23430 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000056469
B2M Beta-2-microglobulin   positive regulation of cellular senescence regulates→occurs inepithelial cell of lung ARUK-UCL Homo sapiens IDA   mhc class ii-related pthr19944 protein   PMID:28213472 2E+07
part ofcellular response to nicotine
PRKDC DNA-dependent protein kinase catalytic subunit   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:D3ZTN0 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000037412
CDK2 Cyclin-dependent kinase 2   cellular senescence   Reactome Homo sapiens TAS   cell division protein kinase pthr24056 protein   Reactome:R-HSA-2559583 2E+07
CTC1 CST complex subunit CTC1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:Q5SUQ9 cst complex subunit ctc1 pthr14865 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000112063
TP53 Cellular tumor antigen p53   cell aging   UniProt Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:12080348 2E+07
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   BHF-UCL Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:19951988 2E+07
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   BHF-UCL Homo sapiens IMP   cellular tumor antigen p53 pthr11447 protein   PMID:19951988 2E+07
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P02340 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
WNT1 Proto-oncogene Wnt-1   negative regulation of cell aging   BHF-UCL Homo sapiens IDA   wnt related pthr12027 protein   PMID:16501043 2E+07
CDKN1B Cyclin-dependent kinase inhibitor 1B   cellular senescence   Reactome Homo sapiens TAS   cyclin-dependent kinase inhibitor 1 pthr10265 protein   Reactome:R-HSA-2559583 2E+07
CHEK2 Serine/threonine-protein kinase Chk2   replicative senescence   BHF-UCL Homo sapiens NAS   ovarian-specific serine/threonine-protein kinase lok-related pthr44167 protein   PMID:15149599 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Homo sapiens ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 protein   GO_REF:0000024 2E+07
SMC5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Homo sapiens IMP   structural maintenance of chromosomes protein 5 pthr45916 protein   PMID:17589526 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   BHF-UCL Homo sapiens IMP   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:15149599 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   BHF-UCL Homo sapiens IMP   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:17553787 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   cellular senescence   Reactome Homo sapiens TAS   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   Reactome:R-HSA-2559583 2E+07
CDKN1A Cyclin-dependent kinase inhibitor 1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:Q564P6 cyclin-dependent kinase inhibitor 1-related pthr46778 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000156559
CDKN1A Cyclin-dependent kinase inhibitor 1   stress-induced premature senescence   BHF-UCL Homo sapiens TAS   cyclin-dependent kinase inhibitor 1-related pthr46778 protein   PMID:20160708 2E+07
LIMS1 LIM and senescent cell antigen-like-containing domain protein 1   cell aging   PINC Homo sapiens TAS   lim domain-containing protein pthr24210 protein   PMID:7517666 2E+07
ARG2 Arginase-2, mitochondrial   positive regulation of cellular senescence   UniProt Homo sapiens IDA   arginase pthr43782 protein   PMID:22928666 2E+07
MAPKAPK5 MAP kinase-activated protein kinase 5   cellular senescence   Reactome Homo sapiens TAS   serine/threonine-protein kinase pthr24349 protein   Reactome:R-HSA-2559583 2E+07
MAPKAPK5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   UniProt Homo sapiens IDA   serine/threonine-protein kinase pthr24349 protein   PMID:17254968 2E+07
VASH1 Tubulinyl-Tyr carboxypeptidase 1   regulation of cellular senescence   MGI Homo sapiens IMP   vasohibin-1-like isoform x2 pthr15750 protein   PMID:23056314 2E+07
ATR Serine/threonine-protein kinase ATR   replicative senescence   BHF-UCL Homo sapiens IMP   ataxia telangiectasia mutated atm -related pthr11139 protein   PMID:15149599 2E+07
MME Neprilysin   replicative senescence   UniProt Homo sapiens IEP   zinc metalloprotease family m13 neprilysin-related pthr11733 protein   PMID:20876573 2E+07
BCL6 B-cell lymphoma 6 protein   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P41183 zinc finger and btb domain-containing pthr24399 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000023151
BMPR1A Bone morphogenetic protein receptor type-1A   regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
NAMPT Nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:Q80Z29 nicotinamide phosphoribosyltransferase pthr43816 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000013043
PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial   regulation of cellular senescence   UniProt Homo sapiens IDA   polyribonucleotide nucleotidyltransferase pthr11252 protein   PMID:16055741 2E+07
SRF Serum response factor   cellular senescence   BHF-UCL Homo sapiens IMP   serum response factor homolog pthr48019 protein   PMID:15282327 2E+07
CDK6 Cyclin-dependent kinase 6   negative regulation of cellular senescence   UniProt Homo sapiens IDA   cell division protein kinase pthr24056 protein   PMID:17420273 2E+07
CGAS Cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Homo sapiens ISS UniProtKB:Q8C6L5 cell fate determining protein mab21-related pthr10656 protein   GO_REF:0000024 2E+07
PLK2 Serine/threonine-protein kinase PLK2   negative regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P53351 serine/threonine-protein kinase plk pthr24345 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000022212
Retinoblastoma-like protein 1   negative regulation of cellular senescence occurs inmicrovascular endothelial cell BHF-UCL Homo sapiens IMP   retinoblastoma-associated protein rb -related pthr13742 protein   PMID:28595801 2E+07  
MAGEA2 Melanoma-associated antigen 2   cellular senescence   UniProt Homo sapiens IDA   melanoma-associated antigen mage antigen pthr11736 protein   PMID:22117195 2E+07
KAT6A Histone acetyltransferase KAT6A   cellular senescence   UniProt Homo sapiens IMP   histone acetyltransferase pthr10615 protein   PMID:23431171 2E+07
MAP3K5 Mitogen-activated protein kinase kinase kinase 5   cellular senescence   Reactome Homo sapiens TAS   serine/threonine protein kinase pthr11584 protein   Reactome:R-HSA-2559583 2E+07
NPM1 Nucleophosmin   cell aging   UniProt Homo sapiens IMP   nucleoplasmin pthr22747 protein   PMID:12080348 2E+07
NOX4 NADPH oxidase 4   cell aging   UniProt Homo sapiens ISS UniProtKB:Q9JHI8 nadph oxidase pthr11972 protein   PMID:10869423 2E+07
NEK6 Serine/threonine-protein kinase Nek6   regulation of cellular senescence   UniProt Homo sapiens TAS   mitogen-activated protein kinase kinase kinase 20-related pthr43289 protein   PMID:21200151 2E+07
MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
ROMO1 Reactive oxygen species modulator 1   replicative senescence   GO_Central Homo sapiens IMP   reactive oxygen species modulator 1 pthr28525 protein   PMID:18836179 2E+07
MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
MAPK9 Mitogen-activated protein kinase 9   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
MAPK8 Mitogen-activated protein kinase 8   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
WRN Werner syndrome ATP-dependent helicase   cell aging   UniProt Homo sapiens IMP   dna helicase recq family member pthr13710 protein   PMID:18212065 2E+07
WRN Werner syndrome ATP-dependent helicase   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:O09053 dna helicase recq family member pthr13710 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
MORC3 MORC family CW-type zinc finger protein 3   cell aging   MGI Homo sapiens IDA   zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   PMID:17332504 2E+07
MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1   cellular senescence   BHF-UCL Homo sapiens IMP   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   PMID:9765203 2E+07
CHEK1 Serine/threonine-protein kinase Chk1   replicative senescence   BHF-UCL Homo sapiens NAS   serine/threonine kinase pthr24343 protein   PMID:15149599 2E+07
TERT Telomerase reverse transcriptase   replicative senescence   BHF-UCL Homo sapiens IMP   telomerase reverse transcriptase pthr12066 protein   PMID:9454332 2E+07
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence occurs invascular associated smooth muscle cell BHF-UCL Homo sapiens IMP   telomerase reverse transcriptase pthr12066 protein   PMID:11313459 2E+07
part ofcellular response to hypoxia
TERT Telomerase reverse transcriptase   negative regulation of cellular senescence occurs inaortic endothelial cell BHF-UCL Homo sapiens IDA   telomerase reverse transcriptase pthr12066 protein   PMID:11927518 2E+07
MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7   cellular senescence   Reactome Homo sapiens TAS   dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   Reactome:R-HSA-2559583 2E+07
SMC6 AAA_23 domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q96SB8   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000404092
PRKCD Protein kinase C delta type   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000331602
YPEL3 Yippee domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P61236   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000381821
RBL1 RB transcriptional corepressor like 1   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P28749   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000362768
FZR1 WD_REPEATS_REGION domain-containing protein   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9R1K5   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000114203
SRF MADS-box domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P11831 serum response factor homolog pthr48019 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265354
TP53 Cellular tumor antigen p53   positive regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P02340   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
TP53 Cellular tumor antigen p53   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P04637   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P04637   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000269305
TP53 Cellular tumor antigen p53   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P02340   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000104298
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   Ensembl Homo sapiens IEA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000013807
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Homo sapiens ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
URS00007E4E8E_9615 Canis lupus familiaris (dog) microRNA cfa-mir-342 precursor   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00760   ncRNA   GO_REF:0000115 2E+07
URS000027000B_9615 Canis lupus familiaris (dog) microRNA cfa-mir-370 precursor   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
URS0000EFD174_9615 Canis lupus familiaris (dog) Cfa-Mir-370 stem-loop   cell aging   RNAcentral Canis lupus familiaris IEA Rfam:RF00740   ncRNA   GO_REF:0000115 2E+07
KRAS GTPase KRas   positive regulation of cellular senescence   Ensembl Homo sapiens IEA UniProtKB:P08644 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000012588
HRAS GTPase HRas   cellular senescence   BHF-UCL Homo sapiens IDA   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:9054499 2E+07
HRAS GTPase HRas   cellular senescence   GO_Central Homo sapiens IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
PRKCD Protein kinase C delta type   cellular senescence   BHF-UCL Homo sapiens IMP   serine/threonine-protein kinase pthr24356 protein   PMID:15282327 2E+07
MNT Max-binding protein MNT   cell aging   Ensembl Homo sapiens IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
TERF2 Telomeric repeat-binding factor 2   cellular senescence   BHF-UCL Homo sapiens NAS   telomeric repeat-binding factor 2 terf2 pthr46833 protein   PMID:17395247 2E+07
TERF2 Telomeric repeat-binding factor 2   negative regulation of cellular senescence occurs inaortic endothelial cell BHF-UCL Homo sapiens IMP   telomeric repeat-binding factor 2 terf2 pthr46833 protein   PMID:11927518 2E+07
MAPK10 Mitogen-activated protein kinase 10   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
CDK1 Cyclin-dependent kinase 1   cell aging   Ensembl Homo sapiens IEA UniProtKB:P39951 cell division protein kinase pthr24056 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000070138
NEK4 Serine/threonine-protein kinase Nek4   regulation of cellular senescence   UniProt Homo sapiens IMP   mitogen-activated kinase kinase kinase pthr24361 protein   PMID:22851694 2E+07
CITED2 Cbp/p300-interacting transactivator 2   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q99MA1 melanocyte specific gene related cited pthr17045 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000074276
KIR2DL4 Killer cell immunoglobulin-like receptor 2DL4   positive regulation of cellular senescence   UniProt Homo sapiens IDA   mhc class i nk cell receptor pthr11738 protein   PMID:23184984 2E+07
KAT5 Histone acetyltransferase KAT5   cellular senescence   Reactome Homo sapiens TAS   histone acetyltransferase pthr10615 protein   Reactome:R-HSA-2559583 2E+07
PRELP Prolargin   cell aging   Ensembl Homo sapiens IEA UniProtKB:Q9JK53 agap008170-pa pthr45712 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
PDCD4 Programmed cell death protein 4   cell aging   UniProt Homo sapiens IDA   programmed cell death 4 pthr12626 protein   PMID:12054647 2E+07
MAPK11 Mitogen-activated protein kinase 11   cellular senescence   Reactome Homo sapiens TAS   mitogen-activated protein kinase pthr24055 protein   Reactome:R-HSA-2559583 2E+07
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Homo sapiens IDA   ribosomal protein l7ae family member pthr23105 protein   PMID:18678645 2E+07
MAP3K3 Mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Homo sapiens IMP   mitogen-activated kinase kinase kinase pthr24361 protein   PMID:28640956 2E+07
TWIST1 Twist-related protein 1   negative regulation of cellular senescence   BHF-UCL Homo sapiens IMP   basic helix-loop-helix transcription factor, twist pthr23349 protein   PMID:17690110 2E+07
PRELP LRRNT domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q9JK53   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000048803
TBX3 TBX domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O15119   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000257567
TBX2 T-box transcription factor TBX2   cellular senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13207 t-box protein-related pthr11267 protein   GO_REF:0000024 2E+07
ABI3 SH3 domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9P2A4   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000225941
WNT16 Protein Wnt   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
WNT16 Protein Wnt   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UBV4 wnt related pthr12027 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000222462
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Canis lupus familiaris ISS UniProtKB:Q13018 mannose, phospholipase, lectin receptor related pthr22803 protein   GO_REF:0000024 2E+07
MORC3 CW-type domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q14149 zinc finger cw-type coiled-coil domain protein 3. pthr23336 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000383333
ABL1 Tyrosine-protein kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P00520 tyrosine-protein kinase pthr24418 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000075167
TP53 Cellular tumor antigen p53   cell aging   UniProt Canis lupus familiaris ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
KAT6A Histone acetyltransferase   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000265713
PNPT1 Polynucleotide phosphorylase 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
BCL2 Apoptosis regulator Bcl-2   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P10417   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371
RSL1D1 Ribosomal L1 domain containing 1   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000460871
Methyltransf_25 domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q6NZB1 protein arginine n-methyltransferase pthr11006 protein   GO_REF:0000107 2E+07  
ensembl:ENSMUSP00000140836  
AKT3 Non-specific serine/threonine protein kinase   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000500582
HMGA1 High mobility group AT-hook protein 1   oncogene-induced cell senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000308227
HMGA1 High mobility group AT-hook protein 1   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000308227
MNT BHLH domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O08789 max dimerization, mad pthr11969 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000000291
SERPINE1 SERPIN domain-containing protein   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000223095
ATR Non-specific serine/threonine protein kinase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000343741
PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN   negative regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O08586 phosphatase with homology to tensin pthr12305 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000013807
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P36895 transforming growth factor-beta receptor type i and ii pthr23255 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
MME Atriopeptidase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P08473   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000353679
WRN DNA helicase   replicative senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O09053   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000033991
ZMPSTE24 CAAX prenyl protease   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q80W54 caax prenyl protease 1 pthr10120 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000053900
TERF2 Telomeric repeat-binding factor   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q15554   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000254942
CGAS Mab-21 domain-containing protein   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q8C6L5   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000063331
ZMIZ1 SP-RING-type domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q6P1E1   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000124863
NEK4 Protein kinase domain-containing protein   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P51957   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000233027
PML PML nuclear body scaffold   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P29590   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000268058
NSMCE2 E3 SUMO-protein ligase NSE2   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q96MF7   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000287437
LMNA Lamin A/C   positive regulation of cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P02545   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000357283
BRCA2 Tower domain-containing protein   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576
TBX2 TBX domain-containing protein   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q13207   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000240328
ZNF277 Zinc finger protein 277   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:E9Q6D6 zinc finger protein 277 pthr13267 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000064226
ARG2 Arginase   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P78540   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000261783
ING2 Inhibitor of growth protein   regulation of cellular senescence   InterPro Canis lupus familiaris IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 protein   GO_REF:0000002 2E+07
ECRG4 ECRG4 augurin precursor   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q99LS0   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000027217
TP63 Tumor protein 63 (p63)   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:O88898 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000110965
OPA1 Dynamin-like 120 kDa protein, form S1   cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:O60313 dynamin pthr11566 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000355324
B2M Beta-2-microglobulin   positive regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:P61769   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000497910
PDCD4 Programmed cell death protein 4   cell aging   Ensembl Canis lupus familiaris IEA UniProtKB:Q53EL6   protein   GO_REF:0000107 2E+07
ensembl:ENSP00000280154
ARNTL Aryl hydrocarbon receptor nuclear translocator like   oxidative stress-induced premature senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9WTL8   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000147989
ARNTL Aryl hydrocarbon receptor nuclear translocator like   regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9WTL8   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000147989
FBXO5 ZBR-type domain-containing protein   negative regulation of cellular senescence   Ensembl Canis lupus familiaris IEA UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000229758
BGLAP Osteocalcin   cell aging   Ensembl Homo sapiens IEA UniProtKB:P04640 osteocalcin pthr14235 protein   GO_REF:0000107 2E+07
ensembl:ENSRNOP00000026530
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Homo sapiens IMP   e3 ubiquitin-protein ligase march5 pthr46283 protein   PMID:20103533 2E+07
ZKSCAN3 Zinc finger protein with KRAB and SCAN domains 3   negative regulation of cellular senescence   UniProt Homo sapiens IMP   zinc finger and scan domain-containing pthr23226 protein   PMID:23434374 2E+07
LMNA Prelamin-A/C   positive regulation of cell aging   UniProt Homo sapiens IDA   lamin dm0-related pthr45721 protein   PMID:20458013 2E+07
ERCC1 DNA excision repair protein ERCC-1   replicative senescence   Ensembl Homo sapiens IEA UniProtKB:P07903 excision repair cross-complementing 1 ercc1 pthr12749 protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000003645
MIF Macrophage migration inhibitory factor   negative regulation of cell aging   BHF-UCL Homo sapiens IDA   d-dopachrome decarboxylase pthr11954 protein   PMID:10562313 2E+07
TBX3 T-box transcription factor TBX3   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11689487 2E+07
TBX3 T-box transcription factor TBX3   cell aging   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:11748239 2E+07
TBX3 T-box transcription factor TBX3   cellular senescence   UniProt Homo sapiens IDA   t-box protein-related pthr11267 protein   PMID:22002537 2E+07
YBX1 CSD domain-containing protein   negative regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:P62960   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589
Lam Lamin   cell aging   FlyBase Drosophila melanogaster IMP   lamin dm0-related pthr45721 protein   FB:FBrf0215933 2E+07
PMID:18494863
kuk kugelkern   cell aging   FlyBase Drosophila melanogaster IMP     protein   FB:FBrf0215933 2E+07
PMID:18494863
Cd36_86310     negative regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_32250     cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
BUD6     extrachromosomal circular DNA localization involved in cell aging   CGD Candida albicans SC5314 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_204790     cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_601870     replicative senescence   CGD Candida parapsilosis CDC317 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
B9J08_004233     extrachromosomal circular DNA localization involved in cell aging   CGD NCBITaxon:498019 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
B9J08_005133     cell aging   CGD NCBITaxon:498019 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0E04246g     regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
SSA2     negative regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000003947 heat shock protein 70kda pthr19375 gene_product   CGD_REF:CAL0121033 2E+07
CAWG_06119     replicative senescence   CGD Candida albicans WO-1 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
PGUG_05750     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CAWG_05096     replicative senescence   CGD Candida albicans WO-1 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
PGUG_05881     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
Aacu16872_051463     replicative senescence   AspGD NCBITaxon:690307 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Aspka1_0181635     replicative senescence   AspGD Aspergillus luchuensis IFO 4308 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Asptu1_0194884     replicative senescence   AspGD NCBITaxon:767770 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
hsp70     negative regulation of cell aging   AspGD Aspergillus fumigatus IEA SGD:S000003947   gene_product   AspGD_REF:ASPL0000000005 2E+07
AFL2T_08396     replicative senescence   AspGD Aspergillus flavus NRRL3357 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
NFIA_074550     replicative senescence   AspGD Aspergillus fischeri NRRL 181 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
AO090012000995     negative regulation of cell aging   AspGD Aspergillus oryzae RIB40 IEA SGD:S000003947   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspzo1_0162899     replicative senescence   AspGD NCBITaxon:41063 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
PDCD4 Programmed cell death protein 4   cell aging   UniProt Gallus gallus ISS UniProtKB:Q53EL6   protein   GO_REF:0000024 2E+07
PNPT1 Polyribonucleotide nucleotidyltransferase   regulation of cellular senescence   Ensembl Gallus gallus IEA UniProtKB:Q8TCS8 polyribonucleotide nucleotidyltransferase pthr11252 protein   GO_REF:0000107 2E+07
ensembl:ENSP00000400646
LELG_00697     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
SSA1     negative regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0G07271g     negative regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_04050     negative regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_01930     replicative senescence   CGD Candida tropicalis MYA-3404 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CORT_0F02830     replicative senescence   CGD NCBITaxon:1136231 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CORT_0A07030     replicative senescence   CGD NCBITaxon:1136231 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CAWG_00610     replicative senescence   CGD Candida albicans WO-1 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
LELG_04803     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
DEHA2C11044g     replicative senescence   CGD Debaryomyces hansenii CBS767 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_05424     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_303700     regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_206750     extrachromosomal circular DNA localization involved in cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
PGUG_04837     replicative senescence   CGD Meyerozyma guilliermondii ATCC 6260 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0B01771g     extrachromosomal circular DNA accumulation involved in cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000002517   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0B01771g     regulation of cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000002517   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_00201     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_04008     replicative senescence   CGD Candida tropicalis MYA-3404 IEA CGD:CAL0126685   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_63010     replicative senescence   CGD Candida dubliniensis CD36 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
TLC1     replicative senescence   CGD [Candida] glabrata CBS 138 IMP     gene_product   CGD_REF:CAL0124495 2E+07
PMID:19840797
TSA1     negative regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000004490 thioredoxin peroxidase pthr10681 gene_product   CGD_REF:CAL0121033 2E+07
EST2     replicative senescence   CGD [Candida] glabrata CBS 138 IMP     gene_product   CGD_REF:CAL0124495 2E+07
PMID:19840797
SGS1     replicative senescence   CGD Candida albicans SC5314 IMP   dna helicase recq family member pthr13710 gene_product   CGD_REF:CAL0119368 2E+07
PMID:18691183
LELG_02334     replicative senescence   CGD Lodderomyces elongisporus NRRL YB-4239 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
CLUG_03791     replicative senescence   CGD Clavispora lusitaniae ATCC 42720 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CORT_0C07310     replicative senescence   CGD NCBITaxon:1136231 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_07650     extrachromosomal circular DNA localization involved in cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
SSA2     negative regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
Cd36_50620     regulation of cell aging   CGD Candida dubliniensis CD36 IEA SGD:S000004500   gene_product   CGD_REF:CAL0121033 2E+07
GCN5     cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000003484   gene_product   CGD_REF:CAL0121033 2E+07
CTRG_02793     replicative senescence   CGD Candida tropicalis MYA-3404 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
CTRG_02792     replicative senescence   CGD Candida tropicalis MYA-3404 IEA InterPro:IPR015519   gene_product   CGD_REF:CAL0142013 2E+07
B9J08_003364     negative regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000003947   gene_product   CGD_REF:CAL0121033 2E+07
B9J08_000645     negative regulation of cell aging   CGD NCBITaxon:498019 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
GCN5     cell aging   CGD Candida albicans SC5314 IEA SGD:S000003484 gh11602p pthr45750 gene_product   CGD_REF:CAL0121033 2E+07
CPAR2_404840     negative regulation of cell aging   CGD Candida parapsilosis CDC317 IEA SGD:S000004490   gene_product   CGD_REF:CAL0121033 2E+07
CAGL0A00891g     extrachromosomal circular DNA localization involved in cell aging   CGD [Candida] glabrata CBS 138 IEA SGD:S000004311   gene_product   CGD_REF:CAL0121033 2E+07
C5_00620W_A     regulation of cell aging   CGD Candida albicans SC5314 IEA SGD:S000004500 cgi-121 family member pthr15840 gene_product   CGD_REF:CAL0121033 2E+07
DEHA2F03388g     replicative senescence   CGD Debaryomyces hansenii CBS767 IEA CGD:CAL0000185821   gene_product   CGD_REF:CAL0121033 2E+07
ECRG4 Uncharacterized protein   cellular senescence   GO_Central Felis catus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
hsp70     negative regulation of cell aging   AspGD Aspergillus nidulans FGSC A4 IEA SGD:S000000004   gene_product   AspGD_REF:ASPL0000000005 2E+07
Aspbr1_0050256     replicative senescence   AspGD Aspergillus brasiliensis CBS 101740 IEA InterPro:IPR015519   gene_product   AspGD_REF:ASPL0000166200 2E+07
Tbx3 T-box 3   cell aging   MGI Mus musculus ISO UniProtKB:O15119 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx3 T-box 3   cell aging   MGI Mus musculus IDA   t-box protein-related pthr11267 protein   MGI:MGI:2159048 2E+07
PMID:11748239
Tbx3 T-box 3   cellular senescence   MGI Mus musculus ISO UniProtKB:O15119 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx2 T-box 2   cell aging   MGI Mus musculus ISO UniProtKB:Q13207 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tbx2 T-box 2   cell aging   MGI Mus musculus IDA   t-box protein-related pthr11267 protein   MGI:MGI:2159048 2E+07
PMID:11748239
Tbx2 T-box 2   cellular senescence   MGI Mus musculus ISO UniProtKB:Q13207 t-box protein-related pthr11267 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Bcl2 B cell leukemia/lymphoma 2   cell aging occurs inEMAPA:18767 MGI Mus musculus IMP MGI:MGI:2156165 bcl-2 related pthr11256 protein   MGI:MGI:62849 2E+07
occurs inT cellmore... PMID:8372353
B2m beta-2 microglobulin   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P61769 mhc class ii-related pthr19944 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Srf serum response factor   cellular senescence   MGI Mus musculus ISO UniProtKB:P11831 serum response factor homolog pthr48019 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt1 wingless-type MMTV integration site family, member 1   negative regulation of cell aging   MGI Mus musculus ISO UniProtKB:P04628 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir290a microRNA 290a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Terf2 telomeric repeat binding factor 2   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Fbxo5 F-box protein 5   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9UKT4 f-box only protein 5 and 43 pthr15493 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir193b microRNA 193b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir671 microRNA 671   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Romo1 reactive oxygen species modulator 1   replicative senescence   MGI Mus musculus ISO UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pawr PRKC, apoptosis, WT1, regulator   positive regulation of cellular senescence occurs infibroblast of cardiac tissue BHF-UCL Mus musculus IMP   prostate apoptosis response protein par-4 pthr15093 protein   MGI:MGI:5648604 2E+07
PMID:25472717
Mir378b microRNA 378b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir370 microRNA 370   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34c microRNA 34c   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34b microRNA 34b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir34a microRNA 34a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir342 microRNA 342   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Twist1 twist basic helix-loop-helix transcription factor 1   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir31 microRNA 31   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir296 microRNA 296   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir25 microRNA 25   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Npm1 nucleophosmin 1   cell aging   MGI Mus musculus ISO UniProtKB:P06748 nucleoplasmin pthr22747 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir19b-1 microRNA 19b-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Smc6 structural maintenance of chromosomes 6   cellular senescence   MGI Mus musculus ISO UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir877 microRNA 877   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Spi1 spleen focus forming virus (SFFV) proviral integration oncogene   oncogene-induced cell senescence occurs infibroblast ARUK-UCL Mus musculus IDA   ets pthr11849 protein   MGI:MGI:6478061 2E+07
occurs inhematopoietic stem cellmore... PMID:28912174
Cdk1 cyclin-dependent kinase 1   cell aging   MGI Mus musculus ISO RGD:2319 cell division protein kinase pthr24056 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mapkapk5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q8IW41 serine/threonine-protein kinase pthr24349 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mapkapk5 MAP kinase-activated protein kinase 5   stress-induced premature senescence   UniProt Mus musculus IMP   serine/threonine-protein kinase pthr24349 protein   MGI:MGI:3697960 2E+07
PMID:17254968
Calr calreticulin   cellular senescence   BHF-UCL Mus musculus IMP   calreticulin and calnexin pthr11073 protein   MGI:MGI:3813434 2E+07
PMID:14726956
Calr calreticulin   cellular senescence   MGI Mus musculus ISO UniProtKB:P27797 calreticulin and calnexin pthr11073 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Sus scrofa ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
BMPR1A Receptor protein serine/threonine kinase   regulation of cellular senescence   Ensembl Sus scrofa IEA UniProtKB:P36895   protein   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000035900
ROMO1 Reactive oxygen species modulator 1   replicative senescence   UniProt Sus scrofa ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
Trp53 transformation related protein 53   cell aging   MGI Mus musculus IGI MGI:MGI:1920086 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:3692019 2E+07
PMID:17053789
Trp53 transformation related protein 53   cell aging   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   positive regulation of cell aging   BHF-UCL Mus musculus IMP   cellular tumor antigen p53 pthr11447 protein   MGI:MGI:5142390 2E+07
PMID:10562313
Trp53 transformation related protein 53   replicative senescence   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Trp53 transformation related protein 53   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:2139971 cellular tumor antigen p53 pthr11447 protein   MGI:MGI:5504576 2E+07
PMID:22904064
Ilk integrin linked kinase   cell aging   MGI Mus musculus ISO RGD:620063 serine/threonine-protein kinase tnni3k-related pthr44329 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mnt max binding protein   cell aging   MGI Mus musculus IMP MGI:MGI:2678322 max dimerization, mad pthr11969 protein   MGI:MGI:2675510 2E+07
PMID:12970171
Mir125b-1 microRNA 125b-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir183 microRNA 183   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir19b-2 microRNA 19b-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Map2k1 mitogen-activated protein kinase kinase 1   cellular senescence   MGI Mus musculus ISO UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Cav1 caveolin 1, caveolae protein   cellular senescence   MGI Mus musculus ISO RGD:2280 caveolin pthr10844 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cgas cyclic GMP-AMP synthase   positive regulation of cellular senescence   UniProt Mus musculus IDA   cell fate determining protein mab21-related pthr10656 protein   MGI:MGI:5909142 2E+07
PMID:28759028
Abi3 ABI family member 3   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9P2A4 abl interactor family member pthr10460 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mapk14 mitogen-activated protein kinase 14   stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q16539 mitogen-activated protein kinase pthr24055 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Rwdd1 RWD domain containing 1   cell aging   CAFA Mus musculus IDA   rwd domain-containing protein pthr12292 protein   MGI:MGI:5882884 2E+07
PMID:18761815
Mir24-2 microRNA 24-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir199a-2 microRNA 199a-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir128-2 microRNA 128-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir125b-2 microRNA 125b-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Rsl1d1 ribosomal L1 domain containing 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O76021 ribosomal protein l7ae family member pthr23105 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wrn Werner syndrome RecQ like helicase   cell aging   MGI Mus musculus ISO UniProtKB:Q14191 dna helicase recq family member pthr13710 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wrn Werner syndrome RecQ like helicase   replicative senescence occurs infibroblast MGI Mus musculus IMP MGI:MGI:2386438 dna helicase recq family member pthr13710 protein   MGI:MGI:1355173 2E+07
PMID:10757812
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   MGI Mus musculus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Hmga2 high mobility group AT-hook 2   negative regulation of cellular senescence occurs inbone marrow cell BHF-UCL Mus musculus IMP   high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:5582375 2E+07
PMID:23072816
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Vash1 vasohibin 1   regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q7L8A9 vasohibin-1-like isoform x2 pthr15750 protein   MGI:MGI:5463671 2E+07
PMID:23056314
Kat6a K(lysine) acetyltransferase 6A   cellular senescence   MGI Mus musculus ISO UniProtKB:Q92794 histone acetyltransferase pthr10615 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Brca2 breast cancer 2, early onset   cell aging   MGI Mus musculus IMP MGI:MGI:2653913 breast cancer type 2 susceptibility protein brca2 pthr11289 protein   MGI:MGI:1277623 2E+07
MGI:MGI:2653914 PMID:9699678
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   UniProt Mus musculus IMP   circadian protein clock/arnt/bmal/pas pthr23042 protein   MGI:MGI:5554364 2E+07
PMID:22101268
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   UniProt Mus musculus IMP   circadian protein clock/arnt/bmal/pas pthr23042 protein   MGI:MGI:5554364 2E+07
PMID:22101268
Mir23b microRNA 23b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Map3k3 mitogen-activated protein kinase kinase kinase 3   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q99759 mitogen-activated kinase kinase kinase pthr24361 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pot1b protection of telomeres 1B   cell aging   MGI Mus musculus IDA   protection of telomeres 1 pthr14513 protein   MGI:MGI:3692019 2E+07
PMID:17053789
Pot1b protection of telomeres 1B   cell aging   MGI Mus musculus IGI MGI:MGI:98834 protection of telomeres 1 pthr14513 protein   MGI:MGI:3692019 2E+07
PMID:17053789
MARCHF5 E3 ubiquitin-protein ligase MARCHF5   negative regulation of cell aging   UniProt Chlorocebus aethiops ISS UniProtKB:Q9NX47   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Pan troglodytes ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
Pten phosphatase and tensin homolog   negative regulation of cell aging   BHF-UCL Mus musculus IMP   phosphatase with homology to tensin pthr12305 protein   MGI:MGI:5009768 2E+07
PMID:21241890
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1   replicative senescence   MGI Mus musculus ISO UniProtKB:P05121 serine protease inhibitor, serpin pthr11461 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir378d microRNA 378d   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Zfp354a zinc finger protein 354A   nucleolar fragmentation   MGI Mus musculus ISO RGD:2967 ip01015p-related pthr24377 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Cdk6 cyclin-dependent kinase 6   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q00534 cell division protein kinase pthr24056 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Eef1e1 eukaryotic translation elongation factor 1 epsilon 1   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O43324 eukaryotic translation elongation factor 1 epsilon-1 pthr44490 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Pdcd4 programmed cell death 4   cell aging   MGI Mus musculus ISO UniProtKB:Q53EL6 programmed cell death 4 pthr12626 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Ypel3 yippee like 3   positive regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:P61236 protein yippee-like cg15309-related pthr13848 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Suv39h1 suppressor of variegation 3-9 1   regulation of cellular senescence   MGI Mus musculus IMP MGI:MGI:2445449 histone-lysine n-methyltransferase suv39h pthr46223 protein   MGI:MGI:5913114 2E+07
PMID:23695662
Dnaja3 DnaJ heat shock protein family (Hsp40) member A3   cell aging   MGI Mus musculus IDA   dnaj homolog subfamily a member 3, mitochondrial pthr44145 protein   MGI:MGI:3525039 2E+07
PMID:15572682
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1338938 tyrosine-protein kinase pthr24418 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase   negative regulation of cellular senescence regulates→occurs inosteoblast MGI Mus musculus IGI MGI:MGI:104738 tyrosine-protein kinase pthr24418 protein   MGI:MGI:5449665 2E+07
PMID:22729085
Prkcd protein kinase C, delta   cellular senescence   MGI Mus musculus ISO UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
polo like kinase 2   negative regulation of cellular senescence occurs inadult endothelial progenitor cell BHF-UCL Mus musculus IMP   serine/threonine-protein kinase plk pthr24345 protein   MGI:MGI:6120300 2E+07  
PMID:27908889  
Mir16-2 microRNA 16-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Icmt isoprenylcysteine carboxyl methyltransferase   regulation of cellular senescence   MGI Mus musculus IGI MGI:MGI:1890508 protein-s isoprenylcysteine o-methyltransferase pthr12714 protein   MGI:MGI:5500993 2E+07
PMID:23686339
TP53 Cellular tumor antigen p53   cell aging   UniProt Meriones unguiculatus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Marmota monax ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
nsmce2 E3 SUMO-protein ligase NSE2   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q96MF7   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Bos indicus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
P50244 S-adenosylmethionine decarboxylase proenzyme   positive regulation of cell aging   UniProt Trypanosoma brucei brucei IMP     protein   PMID:18949025 2E+07
HMGA2 High mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Macaca mulatta ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
HMGA2 High mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Macaca mulatta ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Felis catus ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Pongo abelii ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Macaca mulatta ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
A5HNV6 Inactive S-adenosylmethionine decarboxylase prozyme   positive regulation of cell aging   UniProt Trypanosoma brucei brucei IMP     protein   PMID:18949025 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Callithrix jacchus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Callithrix jacchus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Myotis lucifugus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Myotis lucifugus ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca mulatta ISS UniProtKB:P04637 cellular tumor antigen p53 pthr11447 protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Macaca fascicularis ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Mesocricetus auratus ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Mesocricetus auratus ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Chlorocebus aethiops ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Macaca fascicularis ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Heterocephalus glaber ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Pongo pygmaeus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Hylobates lar ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca fuscata fuscata ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca fascicularis ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Macaca mulatta ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Sapajus apella ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Callithrix jacchus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Equus caballus ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Myotis lucifugus ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
id2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Xenopus tropicalis ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 protein   GO_REF:0000024 2E+07
romo1 Reactive oxygen species modulator 1   replicative senescence   UniProt Xenopus tropicalis ISS UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 protein   GO_REF:0000024 2E+07
romo1 Reactive oxygen species modulator 1   replicative senescence   UniProt Xenopus laevis ISS UniProtKB:P60602   protein   GO_REF:0000024 2E+07
smc6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q96SB8   protein   GO_REF:0000024 2E+07
SERPINE1 Plasminogen activator inhibitor 1   replicative senescence   UniProt Neovison vison ISS UniProtKB:P05121   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Nomascus leucogenys ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
ybx1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P62960   protein   GO_REF:0000024 2E+07
K7_YNL305C K7_Ynl305cp   positive regulation of cell aging   UniProt Saccharomyces cerevisiae Kyokai no. 7 IMP     protein   PMID:21673659 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   oncogene-induced cell senescence   UniProt Cricetulus griseus ISS UniProtKB:P17096   protein   GO_REF:0000024 2E+07
HMGA1 High mobility group protein HMG-I/HMG-Y   positive regulation of cellular senescence   UniProt Cricetulus griseus ISS UniProtKB:P17096   protein   GO_REF:0000024 2E+07
F7I934 Uncharacterized protein   oncogene-induced cell senescence   UniProt Callithrix jacchus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
F7I934 Uncharacterized protein   positive regulation of cellular senescence   UniProt Callithrix jacchus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
MME Neprilysin   replicative senescence   UniProt Pongo abelii ISS UniProtKB:P08473   protein   GO_REF:0000024 2E+07
PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:Q8TCS8   protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Pongo abelii ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
RSL1D1 Ribosomal L1 domain-containing protein 1   regulation of cellular senescence   UniProt Pongo abelii ISS UniProtKB:O76021   protein   GO_REF:0000024 2E+07
Arntl Aryl hydrocarbon receptor nuclear translocator-like protein 1   oxidative stress-induced premature senescence   UniProt Nannospalax galili ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
Arntl Aryl hydrocarbon receptor nuclear translocator-like protein 1   regulation of cellular senescence   UniProt Nannospalax galili ISS UniProtKB:Q9WTL8   protein   GO_REF:0000024 2E+07
id2-b DNA-binding protein inhibitor ID-2-B   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
smc5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Takifugu rubripes ISS UniProtKB:Q8IY18   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Oryctolagus cuniculus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Monodelphis domestica ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
YBX1 Y-box-binding protein 1   negative regulation of cellular senescence   UniProt Oryctolagus cuniculus ISS UniProtKB:P62960   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Cavia porcellus ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Tupaia belangeri ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
SOD1 Superoxide dismutase [Cu-Zn]   cell aging   UniProt Bos grunniens ISS UniProtKB:P00441   protein   GO_REF:0000024 2E+07
ID2 DNA-binding protein inhibitor ID-2   cellular senescence   UniProt Macaca fascicularis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
smc5 Structural maintenance of chromosomes protein 5   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:Q8IY18   protein   GO_REF:0000024 2E+07
MME Atriopeptidase   replicative senescence   UniProt Gorilla gorilla gorilla ISS UniProtKB:P08473 zinc metalloprotease family m13 neprilysin-related pthr11733 protein   GO_REF:0000024 2E+07
smc6 Structural maintenance of chromosomes protein 6   cellular senescence   UniProt Takifugu rubripes ISS UniProtKB:Q96SB8   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   replicative senescence   UniProt Ailuropoda melanoleuca ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
PLA2R1 Phospholipase A2 receptor 1   oxidative stress-induced premature senescence   UniProt Ailuropoda melanoleuca ISS UniProtKB:Q13018   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Cavia porcellus ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
TP53 Cellular tumor antigen p53   cell aging   UniProt Ovis aries ISS UniProtKB:P04637   protein   GO_REF:0000024 2E+07
HMGI-C HMGI family protein HMGI-C   oncogene-induced cell senescence   UniProt Capra hircus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
HMGI-C HMGI family protein HMGI-C   positive regulation of cellular senescence   UniProt Capra hircus ISS UniProtKB:P52926   protein   GO_REF:0000024 2E+07
id2-a DNA-binding protein inhibitor ID-2-A   cellular senescence   UniProt Xenopus laevis ISS UniProtKB:P41136   protein   GO_REF:0000024 2E+07
Akt3 thymoma viral proto-oncogene 3   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt16 wingless-type MMTV integration site family, member 16   replicative senescence   MGI Mus musculus ISO UniProtKB:Q9UBV4 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Wnt16 wingless-type MMTV integration site family, member 16   oxidative stress-induced premature senescence   MGI Mus musculus ISO UniProtKB:Q9UBV4 wnt related pthr12027 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tert telomerase reverse transcriptase   replicative senescence   MGI Mus musculus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Tert telomerase reverse transcriptase   negative regulation of cellular senescence   MGI Mus musculus ISO UniProtKB:O14746 telomerase reverse transcriptase pthr12066 protein   MGI:MGI:4834177 2E+07
GO_REF:0000096
Mir99a microRNA 99a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir30a microRNA 30a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir27a microRNA 27a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir24-1 microRNA 24-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir23a microRNA 23a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir22 microRNA 22   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir211 microRNA 211   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir20a microRNA 20a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir199a-1 microRNA 199a-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir191 microRNA 191   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir188 microRNA 188   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir16-1 microRNA 16-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir15b microRNA 15b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir15a microRNA 15a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir140 microRNA 140   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir134 microRNA 134   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir132 microRNA 132   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir130a microRNA 130a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir128-1 microRNA 128-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mir125a microRNA 125a   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7i microRNA let7i   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7g microRNA let7g   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Nampt nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   MGI Mus musculus ISO RGD:631365 nicotinamide phosphoribosyltransferase pthr43816 protein   MGI:MGI:4417868 2E+07
GO_REF:0000096
Mirlet7f-2 microRNA let7f-2   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7f-1 microRNA let7f-1   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7d microRNA let7d   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Mirlet7b microRNA let7b   cell aging   MGI Mus musculus IDA     gene   MGI:MGI:5643971 2E+07
PMID:25751060
Ctc1 CTS telomere maintenance complex component 1   replicative senescence   MGI Mus musculus IMP MGI:MGI:5427642 cst complex subunit ctc1 pthr14865 protein   MGI:MGI:5426340 2E+07
PMID:22531781
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2   cell aging   RGD Rattus norvegicus IEP   melanocyte specific gene related cited pthr17045 gene   PMID:20569237 2E+07
RGD:5147849
B2m beta-2 microglobulin   positive regulation of cellular senescence regulates→occurs inepithelial cell of lung RGD Rattus norvegicus ISO UniProtKB:P61769 mhc class ii-related pthr19944 gene   RGD:1624291 2E+07
part ofcellular response to nicotine
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   UniProt Rattus norvegicus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 gene   GO_REF:0000024 2E+07
RGD:1600115
Arntl aryl hydrocarbon receptor nuclear translocator-like   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO MGI:1096381 circadian protein clock/arnt/bmal/pas pthr23042 gene   RGD:1624291 2E+07
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q9WTL8 circadian protein clock/arnt/bmal/pas pthr23042 gene   GO_REF:0000024 2E+07
RGD:1600115
Arntl aryl hydrocarbon receptor nuclear translocator-like   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1096381 circadian protein clock/arnt/bmal/pas pthr23042 gene   RGD:1624291 2E+07
Smc5 structural maintenance of chromosomes 5   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q8IY18 structural maintenance of chromosomes protein 5 pthr45916 gene   RGD:1624291 2E+07
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:Q96MF7 uncharacterized pthr21330 gene   GO_REF:0000024 2E+07
RGD:1600115
Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96MF7 uncharacterized pthr21330 gene   RGD:1624291 2E+07
Terf2 telomeric repeat binding factor 2   negative regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO UniProtKB:Q15554 telomeric repeat-binding factor 2 terf2 pthr46833 gene   RGD:1624291 2E+07
Zkscan3 zinc finger with KRAB and SCAN domains 3   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q9BRR0 zinc finger and scan domain-containing pthr23226 gene   RGD:1624291 2E+07
Rsl1d1 ribosomal L1 domain containing 1   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O76021   gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cell aging   RGD Rattus norvegicus ISO MGI:98495 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cell aging   UniProt Rattus norvegicus ISS UniProtKB:O15119 t-box protein-related pthr11267 gene   GO_REF:0000024 2E+07
RGD:1600115
Tbx3 T-box transcription factor 3   cell aging   RGD Rattus norvegicus ISO UniProtKB:O15119 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx3 T-box transcription factor 3   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:O15119 t-box protein-related pthr11267 gene   GO_REF:0000024 2E+07
RGD:1600115
Tbx3 T-box transcription factor 3   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O15119 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Ing2 inhibitor of growth family, member 2   regulation of cellular senescence   InterPro Rattus norvegicus IEA InterPro:IPR028639 inhibitor of growth protein pthr10333 gene   GO_REF:0000002 2E+07
RGD:1600115
Twist1 twist family bHLH transcription factor 1   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q15672 basic helix-loop-helix transcription factor, twist pthr23349 gene   RGD:1624291 2E+07
Spi1 Spi-1 proto-oncogene   oncogene-induced cell senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:98282 ets pthr11849 gene   RGD:1624291 2E+07
occurs inhematopoietic stem cellmore...
Mirlet7f1 microRNA let-7f-1   cell aging   RGD Rattus norvegicus ISO MGI:2676798   gene   RGD:1624291 2E+07
Calr calreticulin   cellular senescence   RGD Rattus norvegicus ISO MGI:88252 calreticulin and calnexin pthr11073 gene   RGD:1624291 2E+07
Calr calreticulin   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P27797 calreticulin and calnexin pthr11073 gene   RGD:1624291 2E+07
Mir193b microRNA 193b   cell aging   RGD Rattus norvegicus ISO MGI:3718458   gene   RGD:1624291 2E+07
Romo1 reactive oxygen species modulator 1   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P60602 reactive oxygen species modulator 1 pthr28525 gene   RGD:1624291 2E+07
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   UniProt Rattus norvegicus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga1 high mobility group AT-hook 1   oncogene-induced cell senescence   RGD Rattus norvegicus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga1 high mobility group AT-hook 1   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P17096 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Suv39h1 SUV39H1 histone lysine methyltransferase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1099440   gene   RGD:1624291 2E+07
Slc30a10 solute carrier family 30, member 10   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q6XR72 fi23527p1 pthr45820 gene   RGD:1624291 2E+07
Prkcd protein kinase C, delta   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 gene UniProtKB:A0A140UHX0 GO_REF:0000107 2E+07
ensembl:ENSP00000331602 RGD:1600115
Prkcd protein kinase C, delta   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q05655 serine/threonine-protein kinase pthr24356 gene   RGD:1624291 2E+07
Cdkn2b cyclin-dependent kinase inhibitor 2B   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P42772 family not named pthr24201 gene UniProtKB:Q5PQW4 GO_REF:0000107 2E+07
ensembl:ENSP00000276925 RGD:1600115
Cdkn2b cyclin-dependent kinase inhibitor 2B   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42772 family not named pthr24201 gene   RGD:1624291 2E+07
Wnt1 Wnt family member 1   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P04628 wnt related pthr12027 gene   RGD:1624291 2E+07
Igf1r insulin-like growth factor 1 receptor   cellular senescence   RGD Rattus norvegicus IEP   tyrosine-protein kinase receptor pthr24416 gene   PMID:19862643 2E+07
RGD:10045872
Id2 inhibitor of DNA binding 2   cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P41136 dna-binding protein inhibitor pthr11723 gene   GO_REF:0000024 2E+07
RGD:1600115
Id2 inhibitor of DNA binding 2   cellular senescence   RGD Rattus norvegicus ISO MGI:96397 dna-binding protein inhibitor pthr11723 gene   RGD:1624291 2E+07
Icam1 intercellular adhesion molecule 1   cell aging   RGD Rattus norvegicus IEP   intercellular adhesion molecule pthr13771 gene   PMID:20421514 2E+07
RGD:4145420
Hras HRas proto-oncogene, GTPase   cell aging   RGD Rattus norvegicus ISO MGI:96224 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   RGD:1624291 2E+07
Hras HRas proto-oncogene, GTPase   cellular senescence   RGD Rattus norvegicus IEP   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:17706954 2E+07
RGD:11060281
Hras HRas proto-oncogene, GTPase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P01112 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   RGD:1624291 2E+07
Hras HRas proto-oncogene, GTPase   cellular senescence   GO_Central Rattus norvegicus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
Fzr1 fizzy and cell division cycle 20 related 1   negative regulation of cell aging   RGD Rattus norvegicus ISO MGI:1926790 cell division cycle 20 cdc20 fizzy -related pthr19918 gene   RGD:1624291 2E+07
Ilk integrin-linked kinase   cell aging   RGD Rattus norvegicus IMP   serine/threonine-protein kinase tnni3k-related pthr44329 gene   PMID:17234816 2E+07
RGD:2301768
Rbl1 RB transcriptional corepressor like 1   negative regulation of cellular senescence occurs inmicrovascular endothelial cell RGD Rattus norvegicus ISO UniProtKB:P28749 retinoblastoma-associated protein rb -related pthr13742 gene   RGD:1624291 2E+07
Pten phosphatase and tensin homolog   negative regulation of cell aging   RGD Rattus norvegicus ISO MGI:109583 phosphatase with homology to tensin pthr12305 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   cell aging   RGD Rattus norvegicus IEP   histone deacetylase sir2 family member pthr11085 gene   PMID:15501022 2E+07
RGD:10047125
Sirt1 sirtuin 1   stress-induced premature senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   negative regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO RGD:13966638 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   negative regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Sirt1 sirtuin 1   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   GO_REF:0000107 2E+07
ensembl:ENSP00000212015 RGD:1600115
Sirt1 sirtuin 1   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96EB6 histone deacetylase sir2 family member pthr11085 gene   RGD:1624291 2E+07
Atr ATR serine/threonine kinase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13535 ataxia telangiectasia mutated atm -related pthr11139 gene   RGD:1624291 2E+07
Nampt nicotinamide phosphoribosyltransferase   negative regulation of cellular senescence   RGD Rattus norvegicus IDA   nicotinamide phosphoribosyltransferase pthr43816 gene   PMID:28125705 2E+07
RGD:13781884
Icmt isoprenylcysteine carboxyl methyltransferase   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1888594 protein-s isoprenylcysteine o-methyltransferase pthr12714 gene   RGD:1624291 2E+07
Prkdc protein kinase, DNA-activated, catalytic subunit   negative regulation of cellular senescence   RGD Rattus norvegicus IMP   ataxia telangiectasia mutated atm -related pthr11139 gene   PMID:22981234 2E+07
RGD:8696027
Mir16 microRNA 16   cell aging   RGD Rattus norvegicus ISO MGI:3618690   gene   RGD:1624291 2E+07
Stk11 serine/threonine kinase 11   positive regulation of cellular senescence occurs inaortic endothelial cell RGD Rattus norvegicus ISO RGD:14067591 family not named pthr43895 gene   RGD:1624291 2E+07
Ecrg4 ECRG4 augurin precursor   cellular senescence   RGD Rattus norvegicus ISO MGI:1926146 augurin pthr31613 gene   RGD:1624291 2E+07
Ecrg4 ECRG4 augurin precursor   cellular senescence   GO_Central Rattus norvegicus IBA PANTHER:PTN002835855 augurin pthr31613 gene   PMID:21873635 2E+07
MGI:MGI:1926146
Rwdd1 RWD domain containing 1   cell aging   RGD Rattus norvegicus ISO MGI:1913771 rwd domain-containing protein pthr12292 gene   RGD:1624291 2E+07
Pot1b protection of telomeres 1B   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:H7BX60 protection of telomeres 1 pthr14513 gene   GO_REF:0000107 2E+07
ensembl:ENSMUSP00000084089 RGD:1600115
Akt3 AKT serine/threonine kinase 3   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 gene UniProtKB:A0A0G2JXD7 GO_REF:0000107 2E+07
ensembl:ENSP00000500582 RGD:1600115
Akt3 AKT serine/threonine kinase 3   negative regulation of cellular senescence occurs inadult endothelial progenitor cell RGD Rattus norvegicus ISO UniProtKB:Q9Y243 serine/threonine-protein kinase pthr24356 gene   RGD:1624291 2E+07
Bcl2l12 BCL2 like 12   negative regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1922986 family not named pthr14965 gene   RGD:1624291 2E+07
Map2k1 mitogen activated protein kinase kinase 1   cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 gene UniProtKB:A0A0H2UHI2 GO_REF:0000107 2E+07
ensembl:ENSP00000302486 RGD:1600115
Map2k1 mitogen activated protein kinase kinase 1   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q02750 dual specificity mitogen-activated protein kinase kinase 5-related pthr48013 gene   RGD:1624291 2E+07
Marchf5 membrane associated ring-CH-type finger 5   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:Q9NX47 e3 ubiquitin-protein ligase march5 pthr46283 gene   RGD:1624291 2E+07
Mnt MAX network transcriptional repressor   cell aging   RGD Rattus norvegicus ISO MGI:109150 max dimerization, mad pthr11969 gene   RGD:1624291 2E+07
Zmpste24 zinc metallopeptidase STE24   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1890508 caax prenyl protease 1 pthr10120 gene   RGD:1624291 2E+07
Kras KRAS proto-oncogene, GTPase   positive regulation of cellular senescence   RGD Rattus norvegicus IMP   ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 gene   PMID:17706954 2E+07
RGD:11060281
Zfp354a zinc finger protein 354A   nucleolar fragmentation   RGD Rattus norvegicus IMP   ip01015p-related pthr24377 gene   PMID:10075651 2E+07
RGD:1303369
Pdcd4 programmed cell death 4   cell aging   UniProt Rattus norvegicus ISS UniProtKB:Q53EL6 programmed cell death 4 pthr12626 gene   GO_REF:0000024 2E+07
RGD:1600115
Pdcd4 programmed cell death 4   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q53EL6 programmed cell death 4 pthr12626 gene   RGD:1624291 2E+07
Ctc1 CST telomere replication complex component 1   replicative senescence   RGD Rattus norvegicus ISO MGI:1916214 cst complex subunit ctc1 pthr14865 gene   RGD:1624291 2E+07
Brca2 BRCA2, DNA repair associated   cell aging   RGD Rattus norvegicus ISO MGI:109337 breast cancer type 2 susceptibility protein brca2 pthr11289 gene   RGD:1624291 2E+07
Brca2 BRCA2, DNA repair associated   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P97929 breast cancer type 2 susceptibility protein brca2 pthr11289 gene UniProtKB:Q66MH4 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000038576 RGD:1600115
Bglap bone gamma-carboxyglutamate protein   cell aging   RGD Rattus norvegicus IEP   osteocalcin pthr14235 gene   PMID:19840645 2E+07
RGD:2316145
Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit   replicative senescence occurs infibroblast RGD Rattus norvegicus ISO MGI:95412 excision repair cross-complementing 1 ercc1 pthr12749 gene   RGD:1624291 2E+07
Zmiz1 zinc finger, MIZ-type containing 1   cell aging   RGD Rattus norvegicus ISO MGI:3040693 zinc finger miz domain-containing protein pthr10782 gene   RGD:1624291 2E+07
Arg2 arginase 2   positive regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P78540 arginase pthr43782 gene UniProtKB:G3V7H6 GO_REF:0000107 2E+07
ensembl:ENSP00000261783 RGD:1600115
Arg2 arginase 2   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P78540 arginase pthr43782 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   UniProt Rattus norvegicus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga2 high mobility group AT-hook 2   oncogene-induced cell senescence   RGD Rattus norvegicus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   negative regulation of cellular senescence occurs inbone marrow cell RGD Rattus norvegicus ISO MGI:101761 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   GO_REF:0000024 2E+07
RGD:1600115
Hmga2 high mobility group AT-hook 2   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P52926 high mobility group proteins hmg-a and c pthr23341 gene   RGD:1624291 2E+07
Cav1 caveolin 1   cellular senescence   RGD Rattus norvegicus IMP   caveolin pthr10844 gene   PMID:23941874 2E+07
RGD:9588563
Htt huntingtin   cell aging   RGD Rattus norvegicus ISO MGI:96067 huntington disease protein pthr10170 gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cell aging   RGD Rattus norvegicus ISO MGI:104738   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence occurs inosteoblast RGD Rattus norvegicus ISO MGI:104738   gene   RGD:1624291 2E+07
occurs inosteoblast
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
UniProtKB:Q8N726
Cdkn2a cyclin-dependent kinase inhibitor 2A   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Cdkn2a cyclin-dependent kinase inhibitor 2A   positive regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P42771   gene   RGD:1624291 2E+07
Zfp277 zinc finger protein 277   regulation of cellular senescence   RGD Rattus norvegicus ISO MGI:1890393 zinc finger protein 277 pthr13267 gene   RGD:1624291 2E+07
Lmna lamin A/C   positive regulation of cell aging   UniProt Rattus norvegicus ISS UniProtKB:P02545 lamin dm0-related pthr45721 gene   GO_REF:0000024 2E+07
RGD:1600115
Lmna lamin A/C   positive regulation of cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P02545 lamin dm0-related pthr45721 gene UniProtKB:G3V8L3 GO_REF:0000107 2E+07
ensembl:ENSP00000357283 RGD:1600115
Lmna lamin A/C   positive regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:P02545 lamin dm0-related pthr45721 gene   RGD:1624291 2E+07
Lmna lamin A/C   cellular senescence   RGD Rattus norvegicus IEP   lamin dm0-related pthr45721 gene   PMID:20362703 2E+07
RGD:12791030
Sod1 superoxide dismutase 1   cell aging   UniProt Rattus norvegicus ISS UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 gene   GO_REF:0000024 2E+07
RGD:1600115
Sod1 superoxide dismutase 1   cell aging   RGD Rattus norvegicus ISO UniProtKB:P00441 superoxide dismutase cu-zn -related pthr10003 gene   RGD:1624291 2E+07
Smc6 structural maintenance of chromosomes 6   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q96SB8 structural maintenance of chromosomes 5,6 smc5, smc6 pthr19306 gene   RGD:1624291 2E+07
Dnaja3 DnaJ heat shock protein family (Hsp40) member A3   cell aging   RGD Rattus norvegicus ISO MGI:1933786 dnaj homolog subfamily a member 3, mitochondrial pthr44145 gene   RGD:1624291 2E+07
Wnt16 Wnt family member 16   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UBV4 wnt related pthr12027 gene   RGD:1624291 2E+07
Wnt16 Wnt family member 16   oxidative stress-induced premature senescence   RGD Rattus norvegicus ISO UniProtKB:Q9UBV4 wnt related pthr12027 gene   RGD:1624291 2E+07
Foxm1 forkhead box M1   negative regulation of cell aging   Ensembl Rattus norvegicus IEA UniProtKB:Q08050 forkhead box protein m1 pthr46878 gene UniProtKB:D3ZLE1 GO_REF:0000107 2E+07
ensembl:ENSP00000352901 RGD:1600115
Foxm1 forkhead box M1   negative regulation of cell aging   RGD Rattus norvegicus ISO UniProtKB:Q08050 forkhead box protein m1 pthr46878 gene   RGD:1624291 2E+07
Bcl2 BCL2, apoptosis regulator   cell aging occurs inEMAPA:18767 RGD Rattus norvegicus ISO MGI:88138 bcl-2 related pthr11256 gene   RGD:1624291 2E+07
occurs inT cellmore...
Bcl2 BCL2, apoptosis regulator   cell aging   Ensembl Rattus norvegicus IEA UniProtKB:P10417 bcl-2 related pthr11256 gene UniProtKB:F1LNV0 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000108371 RGD:1600115
Cdk1 cyclin-dependent kinase 1   cell aging   RGD Rattus norvegicus IDA   cell division protein kinase pthr24056 gene   PMID:15695611 2E+07
RGD:2301352
Mtor mechanistic target of rapamycin kinase   cell aging   RGD Rattus norvegicus IEP   ataxia telangiectasia mutated atm -related pthr11139 gene   PMID:19698731 2E+07
RGD:10003167
Abi3 ABI family, member 3   positive regulation of cellular senescence part ofdefense response to tumor cell RGD Rattus norvegicus ISO UniProtKB:Q9P2A4 abl interactor family member pthr10460 gene   RGD:1624291 2E+07
Mirlet7g microRNA let-7g   cell aging   RGD Rattus norvegicus ISO MGI:2676800   gene   RGD:1624291 2E+07
Ybx1 Y box binding protein 1   negative regulation of cellular senescence   UniProt Rattus norvegicus ISS UniProtKB:P62960 cold shock domain containing proteins pthr11544 gene   GO_REF:0000024 2E+07
RGD:1600115
Ybx1 Y box binding protein 1   negative regulation of cellular senescence   Ensembl Rattus norvegicus IEA UniProtKB:P62960 cold shock domain containing proteins pthr11544 gene UniProtKB:Q3ZAV2 GO_REF:0000107 2E+07
ensembl:ENSMUSP00000078589 RGD:1600115
Nek4 NIMA-related kinase 4   regulation of cellular senescence   RGD Rattus norvegicus ISO UniProtKB:P51957 mitogen-activated kinase kinase kinase pthr24361 gene   RGD:1624291 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   extrachromosomal circular DNA accumulation involved in cell aging   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:O13329 PMID:10230397 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:O13329 PMID:25822194 2E+07
FOB1 Nucleolar protein that binds the rDNA replication fork barrier site   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IGI SGD:S000004500   protein UniProtKB:O13329 PMID:25822194 2E+07
MED2 Subunit of the RNA polymerase II mediator complex   replicative senescence   SGD Saccharomyces cerevisiae S288C IMP     protein UniProtKB:Q12124 PMID:33045248 2E+07
SSA1 ATPase involved in protein folding and NLS-directed nuclear transport   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   heat shock protein 70kda pthr19375 protein UniProtKB:P10591 PMID:27264606 2E+07
Atm ATM serine/threonine kinase   replicative senescence   RGD Rattus norvegicus ISO UniProtKB:Q13315 ataxia telangiectasia mutated atm -related pthr11139 gene   RGD:1624291 2E+07
Eef1e1 eukaryotic translation elongation factor 1 epsilon 1   positive regulation of cellular senescence occurs inmesenchymal stem cell RGD Rattus norvegicus ISO UniProtKB:O43324 eukaryotic translation elongation factor 1 epsilon-1 pthr44490 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cell aging   RGD Rattus norvegicus ISO MGI:98494 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cell aging   RGD Rattus norvegicus ISO UniProtKB:Q13207 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Tbx2 T-box transcription factor 2   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:Q13207 t-box protein-related pthr11267 gene   RGD:1624291 2E+07
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   ParkinsonsUK-UCL Rattus norvegicus ISS UniProtKB:O60313 dynamin pthr11566 gene   GO_REF:0000024 2E+07
RGD:1600115
Opa1 OPA1, mitochondrial dynamin like GTPase   cellular senescence   RGD Rattus norvegicus ISO UniProtKB:O60313 dynamin pthr11566 gene   RGD:1624291 2E+07
CGI121 Component of the EKC/KEOPS complex   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   cgi-121 family member pthr15840 protein UniProtKB:Q03705 PMID:25822194 2E+07
CGI121 Component of the EKC/KEOPS complex   regulation of cell aging   SGD Saccharomyces cerevisiae S288C IGI SGD:S000002517 cgi-121 family member pthr15840 protein UniProtKB:Q03705 PMID:25822194 2E+07
SSA2 HSP70 family ATP-binding protein   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   heat shock protein 70kda pthr19375 protein UniProtKB:P10592 PMID:27264606 2E+07
TSA1 Thioredoxin peroxidase   negative regulation of cell aging   SGD Saccharomyces cerevisiae S288C IMP   thioredoxin peroxidase pthr10681 protein UniProtKB:P34760 PMID:27264606 2E+07
BUD6 Actin- and formin-interacting protein   extrachromosomal circular DNA localization involved in cell aging   SGD Saccharomyces cerevisiae S288C IMP   p140cap/snip-related pthr22741 protein UniProtKB:P41697 PMID:18660802 2E+07
ALB3 ALBINO 3   regulation of cell aging   TAIR Arabidopsis thaliana IMP   oxa1 pthr12428 protein TAIR:locus:2053230 TAIR:Publication:501732666 2E+07
PMID:18713382
HRAS HRas proto-oncogene, GTPase   cellular senescence   GO_Central Equus caballus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
ECRG4 Chromosome 15 C2orf40 homolog   cellular senescence   GO_Central Equus caballus IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS GTPase HRas isoform 1   cellular senescence   GO_Central Sus scrofa IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
G3R5Z7 Chromosome 2 open reading frame 40   cellular senescence   GO_Central Gorilla gorilla gorilla IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS HRas proto-oncogene, GTPase   cellular senescence   GO_Central Canis lupus familiaris IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
HRAS HRAS isoform 2   cellular senescence   GO_Central Pan troglodytes IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C2orf40 Uncharacterized protein   cellular senescence   GO_Central Monodelphis domestica IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
C2AH2orf40 C2orf40 isoform 1   cellular senescence   GO_Central Pan troglodytes IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
XB-GENE-997587 Augurin   cellular senescence   GO_Central Xenopus tropicalis IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
A0A2I2YWA2 HRas proto-oncogene, GTPase   cellular senescence   GO_Central Gorilla gorilla gorilla IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
HRAS GTPase HRas isoform 1   cellular senescence   GO_Central Macaca mulatta IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C10H2orf40 Chromosome 10 C2orf40 homolog   cellular senescence   GO_Central Canis lupus familiaris IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635 2E+07
MGI:MGI:1926146
HRAS Uncharacterized protein   cellular senescence   GO_Central Felis catus IBA PANTHER:PTN000632466 ras, di-ras, and rheb family members of small gtpase superfamily pthr24070 protein   PMID:21873635 2E+07
RGD:2827
UniProtKB:P01112
C2orf40 Uncharacterized protein   cellular senescence   GO_Central Sus scrofa IBA PANTHER:PTN002835855 augurin pthr31613 protein   PMID:21873635  
Source: AmiGo 2