Ras induced exosome SASP(Day 10); Human fibroblasts

Comparison

UniProtIds

Protein Description

Genes

Log2 Ratio

Std. Dev.

PValue

QValue

GO Biological Process

GO Molecular Process

GO Cellular Process

Ratios

Unique Peptides

Elution Groups

Elution Group

SEN / CTL

P05362

Intercellular adhesion molecule 1

ICAM1

5.86

2.42

9.59e-20

2.4e-17

ovarian follicle development,regulation of leukocy...

virus receptor activity,receptor activity,transmem...

immunological synapse,extracellular space,plasma m...

55

18

22

GGSVLVTC[CAM]STSC[CAM]DQPK.2|DGTFPLPIGESVTVTR.2|LL...

SEN / CTL

P29966

Myristoylated alanine-rich C-kinase substrate

MARCKS

4.06

1.83

0.00609

0.0374

regulation of insulin secretion

protein kinase C binding,calmodulin binding,actin ...

centrosome,plasma membrane,focal adhesion,cell cor...

5

20

36

TAAKGEAAAERPGEAAVASSPSK.4|TAAKGEAAAERPGEAAVASSPSK....

SEN / CTL

P22692

Insulin-like growth factor-binding protein 4

IGFBP4

3.5

2.45

0.00121

0.0138

skeletal system development,regulation of cell gro...

receptor binding,insulin-like growth factor I bind...

extracellular region,extracellular space

15

3

5

EDARPVPQGSC[CAM]QSELHR.4|GELDC[CAM]HQLADSFRE.3|GEL...

SEN / CTL

P21589

5'-nucleotidase

NT5E

2.82

2.62

0.0000446

0.000857

purine nucleotide catabolic process,AMP catabolic ...

nucleotide binding,5'-nucleotidase activity,metal ...

cytoplasm,plasma membrane,cell surface,membrane,an...

125

28

42

FPILSANIK.2|TIVYLDGSSQSC[CAM]R.2|EVPAGKYPFIVTSDDGR...

SEN / CTL

P04083

Annexin A1

ANXA1

2.63

2.25

3.83e-9

4.78e-7

DNA strand renaturation,neutrophil homeostasis,ada...

single-stranded DNA binding,single-stranded RNA bi...

cornified envelope,phagocytic cup,extracellular re...

170

38

69

TPAQFDADELR.2|GVDEATIIDILTKR.3|NALLSLAK.2|DLAKDITS...

SEN / CTL

Q15758

Neutral amino acid transporter B(0)

SLC1A5

2.61

3.37

0.00168

0.0171

amino acid transmembrane transport,extracellular a...

virus receptor activity,receptor activity,protein ...

Golgi apparatus,plasma membrane,integral component...

25

16

21

STEPELIQVK.2|SELPLDPLPVPTEEGNPLLK.3|SELPLDPLPVPTEE...

SEN / CTL

P26038

Moesin

MSN

2.37

2.3

0.00288

0.0249

movement of cell or subcellular component,cytoskel...

double-stranded RNA binding,actin binding,receptor...

uropod,extracellular space,nucleus,cytoplasm,cytos...

190

65

122

IGFPWSEIR.2|ERQEAEEAKEALLQASR.4|ERQEAEEAKEALLQASR....

SEN / CTL

P80723

Brain acid soluble protein 1

BASP1

2.34

2.63

5.45e-8

0.00000341

thorax and anterior abdomen determination,gonad de...

transcription corepressor activity,protein binding...

nucleus,cytoplasm,cytoskeleton,plasma membrane,nuc...

60

28

41

AQGPAASAEEPKPVEAPAANSDQTVTVKE.3|AQGPAASAEEPKPVEAPA...

SEN / CTL

Q09666

Neuroblast differentiation-associated protein AHNAK

AHNAK

2.3

2.21

0.00447

0.0307

regulation of RNA splicing,protein oligomerization...

protein binding,S100 protein binding,poly(A) RNA b...

nucleus,cytoplasm,lysosomal membrane,cytosol,plasm...

280

433

666

LPTGQISGPEIK.2|LNVGAPDVTLR.2|ISMPEVDLNLKGPK.3|IKGD...

SEN / CTL

P09972

Fructose-bisphosphate aldolase C

ALDOC

2.06

2.08

0.0000484

0.000865

fructose metabolic process,gluconeogenesis,fructos...

fructose-bisphosphate aldolase activity,protein bi...

mitochondrion,cytosol,cytoskeleton,extracellular e...

30

27

42

VDKGVVPLAGTDGETTTQGLDGLSER.3|VDKGVVPLAGTDGETTTQGLD...

SEN / CTL

P17301

Integrin alpha-2

ITGA2

1.84

2.04

0.00000322

0.000101

response to hypoxia,positive regulation of leukocy...

virus receptor activity,integrin binding,protein b...

nucleus,plasma membrane,focal adhesion,integrin co...

95

27

31

KGILGQHQFLEGPEGIENTR.3|VVFNLNTYK.2|SVAC[CAM]DVGYPA...

SEN / CTL

P04004

Vitronectin

VTN

1.68

1.43

0.00442

0.0307

receptor-mediated endocytosis,immune response,cell...

scavenger receptor activity,integrin binding,prote...

extracellular region,basement membrane,extracellul...

15

22

33

DVWGIEGPIDAAFTR.2|DVWGIEGPIDAAFTR.3|LIRDVWGIEGPIDA...

SEN / CTL

P19013

Keratin, type II cytoskeletal 4

KRT4

1.59

1.49

0.00233

0.0224

cytoskeleton organization,epithelial cell differen...

structural molecule activity,protein binding

nucleus,intermediate filament,cell surface,keratin...

25

21

22

LALDIEIATYR.2|FASFIDKVQFLEQQNK.3|NLDLDSIIAEVR.2|II...

SEN / CTL

P07355

Annexin A2

ANXA2

1.54

2.4

1.43e-7

0.00000714

angiogenesis,membrane raft assembly,positive regul...

protease binding,calcium ion binding,protein bindi...

ruffle,basement membrane,extracellular space,nucle...

285

49

99

DLYDAGVK.2|AEDGSVIDYELIDQDAR.3|AEDGSVIDYELIDQDAR.2...

SEN / CTL

Q12931

Heat shock protein 75 kDa, mitochondrial

TRAP1

1.42

0.87

0.00114

0.0135

response to stress,translational attenuation,chape...

tumor necrosis factor receptor binding,protein bin...

nucleoplasm,mitochondrion,mitochondrial inner memb...

10

53

85

GVVDSEDIPLNLSR.2|GVVDSEDIPLNLSR.3|LNELLVK.2|HLAEHS...

SEN / CTL

P06702

Protein S100-A9

S100A9

1.32

0.97

0.00314

0.0259

cytokine production,leukocyte migration involved i...

signal transducer activity,calcium ion binding,pro...

extracellular region,extracellular space,nucleus,c...

10

18

44

LGHPDTLNQGEFK.3|LGHPDTLNQGEFK.2|NIETIINTFHQYSVK.3|...

SEN / CTL

P04406

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

1.09

2.29

0.0000371

0.000857

microtubule cytoskeleton organization,gluconeogene...

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (p...

nucleus,cytoplasm,lipid particle,cytosol,plasma me...

140

51

166

VPTANVSVVDLTC[CAM]R.2|VPTANVSVVDLTC[CAM]R.3|GALQNI...

SEN / CTL

Q86YZ3

Hornerin

HRNR

1.06

1

0.00613

0.0374

keratinization,cell envelope organization,establis...

calcium ion binding

cornified envelope,nucleus,cytoplasm,cell envelope...

15

34

56

HGSGSGQSSSYSPYGSGSGWSSSR.3|HGSGSGQSSSYGPYGSGSGWSSS...

SEN / CTL

P69905

Hemoglobin subunit alpha

HBA1

1.06

1.55

0.00724

0.0431

receptor-mediated endocytosis,positive regulation ...

oxygen transporter activity,iron ion binding,prote...

extracellular region,cytosol,hemoglobin complex,me...

35

23

78

MFLSFPTTK.2|M[Oxi]FLSFPTTK.2|LRVDPVNFK.2|VGAHAGEYG...

SEN / CTL

Q562R1

Beta-actin-like protein 2

ACTBL2

0.71

2.68

0.000528

0.00826

biological_process

molecular_function,ATP binding

extracellular space,cytoplasm,cytoskeleton,extrace...

45

9

17

VAPDEHPILLTEAPLNPK.3|VAPDEHPILLTEAPLNPK.4|KDLYANTV...

SEN / CTL

P60709

P63261

Actin, cytoplasmic 1;Actin, cytoplasmic 2

ACTB

ACTG1

0.32

2.14

0.0000184

0.000512

retina homeostasis,movement of cell or subcellular...

structural constituent of cytoskeleton,protein bin...

nuclear chromatin,extracellular space,nucleoplasm,...

160

11

55

GYSFTTTAER.2|VAPEEHPVLLTEAPLNPK.3|VAPEEHPVLLTEAPLN...

SEN / CTL

P13929

Beta-enolase

ENO3

0.18

3.05

0.000638

0.00926

gluconeogenesis,aging,response to drug,skeletal mu...

magnesium ion binding,phosphopyruvate hydratase ac...

phosphopyruvate hydratase complex,extracellular sp...

25

16

23

VNQIGSVTESIQAC[CAM]K.2|VNQIGSVTESIQAC[CAM]K.3|YGKD...

SEN / CTL

P68032

Actin, alpha cardiac muscle 1

ACTC1

-0.2

2.72

0.00512

0.0333

apoptotic process,positive regulation of gene expr...

ATP binding,ATPase activity,myosin binding

extracellular space,cytoplasm,cytosol,actin filame...

225

28

98

SYELPDGQVITIGNER.2|SYELPDGQVITIGNER.3|AVFPSIVGRPR....

SEN / CTL

P06733

Alpha-enolase

ENO1

-0.49

2.16

0.0000415

0.000857

gluconeogenesis,transcription, DNA-templated,respo...

magnesium ion binding,DNA binding,phosphopyruvate ...

phosphopyruvate hydratase complex,extracellular sp...

120

54

117

VNQIGSVTESLQAC[CAM]K.2|VNQIGSVTESLQAC[CAM]K.3|AAVP...

SEN / CTL

P22392

Nucleoside diphosphate kinase B

NME2

-0.68

1

0.00455

0.0307

negative regulation of myeloid leukocyte different...

DNA binding,transcription factor activity, sequenc...

ruffle,nucleus,cytoplasm,cytosol,intermediate fila...

30

19

36

GDFC[CAM]IQVGR.2|SC[CAM]AHDWVYE.2|TFIAIKPDGVQR.3|T...

SEN / CTL

P56199

Integrin alpha-1

ITGA1

-0.83

1.51

0.00271

0.0242

activation of MAPK activity,muscle contraction,cel...

receptor binding,protein binding,collagen binding,...

acrosomal vesicle,plasma membrane,focal adhesion,i...

30

13

15

VIQDC[CAM]EDENIQR.2|ASQIIIPR.2|FGTAIAAVK.2|FSIAILG...

SEN / CTL

Q8WUM4

Programmed cell death 6-interacting protein

PDCD6IP

-0.87

1.6

0.00000135

0.0000482

cell separation after cytokinesis,apoptotic proces...

protein binding,proteinase activated receptor bind...

immunological synapse,cytoplasm,microtubule organi...

130

63

96

STPVNVPISQK.2|EVFPVLAAK.2|FYNELTEILVR.2|LANQAADYFG...

SEN / CTL

P16401

Histone H1.5

HIST1H1B

-0.87

1.2

0.00404

0.0306

negative regulation of transcription from RNA poly...

chromatin DNA binding,histone deacetylase binding,...

nucleosome,nuclear chromatin,nuclear heterochromat...

30

13

17

ALAAGGYDVEK.2|ALAAGGYDVEKNNSR.3|KATGPPVSELITK.3|KA...

SEN / CTL

P60866

40S ribosomal protein S20

RPS20

-1.08

1.13

0.000667

0.00926

nuclear-transcribed mRNA catabolic process, nonsen...

structural constituent of ribosome,poly(A) RNA bin...

nucleoplasm,cytoplasm,cytosol,membrane,cytosolic s...

15

5

10

LIDLHSPSEIVK.3|LIDLHSPSEIVK.2|DTGKTPVEPEVAIHR.4|DT...

SEN / CTL

P14618

Pyruvate kinase PKM

PKM

-1.08

2.43

0.000759

0.00999

programmed cell death,canonical glycolysis,cell-ce...

magnesium ion binding,pyruvate kinase activity,pro...

nucleus,cytoplasm,mitochondrion,cytosol,plasma mem...

225

71

161

GDLGIEIPAEK.2|KGVNLPGAAVDLPAVSEKDIQDLK.4|KGVNLPGAA...

SEN / CTL

P04217

Alpha-1B-glycoprotein

A1BG

-1.13

0.42

0.00442

0.0307

platelet degranulation,biological_process

molecular_function

extracellular region,extracellular space,platelet ...

5

21

40

GVTFLLR.2|RGEKELLVPR.3|LELHVDGPPPR.3|LELHVDGPPPRPQ...

SEN / CTL

P12110

Collagen alpha-2(VI) chain

COL6A2

-1.22

2.42

0.000414

0.00691

cell adhesion,response to glucose,extracellular ma...

extracellular region,proteinaceous extracellular m...

155

42

57

NFVINVVNR.2|LFAVAPNQNLK.2|VFAVVITDGR.2|DIASTPHELYR...

SEN / CTL

Q9Y4K0

Lysyl oxidase homolog 2

LOXL2

-1.31

2.08

0.00327

0.0259

response to hypoxia,epithelial to mesenchymal tran...

chromatin binding,transcription corepressor activi...

basement membrane,extracellular space,nucleus,nucl...

35

16

19

VVC[CAM]GMFGFPGER.2|FNAESQGC[CAM]NHEEDAGVR.3|LGQGI...

SEN / CTL

P62249

40S ribosomal protein S16

RPS16

-1.44

1.87

0.00519

0.0333

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleoplasm,cytosol,focal adhesion,small ribosomal...

30

14

19

TLLVADPR.2|LLEPVLLLGK.2|EIKDILIQYDR.3|EIKDILIQYDR....

SEN / CTL

P10412

P16402

P16403

Histone H1.4;Histone H1.3;Histone H1.2

HIST1H1E

HIST1H1D

HIST1H1C

-1.62

1.75

0.0000436

0.000857

negative regulation of transcription from RNA poly...

protein binding,chromatin DNA binding,poly(A) RNA ...

nucleosome,nucleus,nuclear heterochromatin,extrace...

45

7

12

ALAAAGYDVEK.2|ALAAAGYDVEKNNSR.3|ALAAAGYDVEKNNSR.2|...

SEN / CTL

P12109

Collagen alpha-1(VI) chain

COL6A1

-1.71

1.78

5.6e-7

0.0000233

osteoblast differentiation,cell adhesion,extracell...

platelet-derived growth factor binding

extracellular region,collagen type VI trimer,lysos...

195

49

69

IALVITDGR.2|VPSYQALLR.2|VFSVAITPDHLEPR.3|VFSVAITPD...

SEN / CTL

P62805

Histone H4

HIST1H4A

-1.84

2.74

0.000849

0.0106

chromatin silencing at rDNA,double-strand break re...

DNA binding,protein binding,protein domain specifi...

nuclear chromosome,nuclear chromosome, telomeric r...

80

24

44

DNIQGITKPAIR.3|DNIQGITKPAIR.2|ISGLIYEETR.2|VFLENVI...

SEN / CTL

P13646

Keratin, type I cytoskeletal 13

KRT13

-2.33

2.53

0.00332

0.0259

cytoskeleton organization,response to radiation,to...

structural molecule activity

nucleus,keratin filament,intermediate filament cyt...

20

11

16

VILEIDNAR.2|ILTATIENNR.2|ITMQNLNDR.2|ITM[Oxi]QNLND...

SEN / CTL

P12111

Collagen alpha-3(VI) chain

COL6A3

-2.78

2.24

1.61e-8

0.00000134

cell adhesion,muscle organ development,negative re...

serine-type endopeptidase inhibitor activity

extracellular region,proteinaceous extracellular m...

855

165

233

ELPNIEER.2|EVQVFEITENSAK.2|YIAYLVR.2|LLVLITGGK.2|A...

SEN / CTL

O60814

P57053

P58876

P62807

Q5QNW6

Q93079

Q99877

Q99879

Q99880

Histone H2B type 1-K;Histone H2B type F-S;Histone H2B type 1-D;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-F;Histone H2B type 1-H;Histone H2B type 1-N;Histone H2B type 1-M;Histone H2B type 1-L

HIST1H2BK

H2BFS

HIST1H2BD

HIST1H2BC

HIST2H2BF

HIST1H2BH

HIST1H2BN

HIST1H2BM

HIST1H2BL

-4.26

3.12

0.00268

0.0242

innate immune response in mucosa,nucleosome assemb...

molecular_function,DNA binding,protein heterodimer...

nuclear nucleosome,extracellular space,nucleus,nuc...

15

2

3

ESYSVYVYK.2|KESYSVYVYK.3|KESYSVYVYK.2

SEN / CTL

Q14114

Low-density lipoprotein receptor-related protein 8

LRP8

-4.28

1.16

0.00162

0.0171

negative regulation of transcription from RNA poly...

transmembrane signaling receptor activity,low-dens...

extracellular region,microtubule associated comple...

5

1

1

AIAVDPLR.2

SEN / CTL

P06899

P23527

P33778

Q16778

Q8N257

Histone H2B type 1-J;Histone H2B type 1-O;Histone H2B type 1-B;Histone H2B type 2-E;Histone H2B type 3-B

HIST1H2BJ

HIST1H2BO

HIST1H2BB

HIST2H2BE

HIST3H2BB

-5.52

3.23

0.00171

0.0171

innate immune response in mucosa,nucleosome assemb...

DNA binding,protein heterodimerization activity;DN...

nucleosome,nuclear nucleosome,extracellular space,...

40

4

12

LLLPGELAK.2|ESYSIYVYK.2|AMGIMNSFVNDIFER.2|AMGIMNSF...

Reference: SenQuest