Aging and Senescence

      Human
ID Gene/Variant Chromosomal Location Population Studied Findings References
ABCA1 9q31.1 Japanese Non-significant (study details) Arai et al. (2003)
316 ABCC4 13q32.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
253 ACE 17q23.3 Greek Significant (study details) Kolovou et al. (2014)
162 ACE 17q23.3 Chinese (Uighur in Xinjiang) Significant (study details) Wufuer et al. (2004)
130 ACE 17q23.3 Russian (Novosibirsk) Significant (study details) Shabalin et al. (2003)
98 ACE 17q23.3 Korean Non-significant (study details) Choi et al. (2003)
126 ACE 17q23.3 Brazilian of European and Japanese origin Significant (study details) Da Cruz et al. (2003)
222 ACE 17q23.3 Italian (Southern) Significant (study details) Seripa et al. (2006)
62 ACE 17q23.3 American (Caucasian) Non-significant (study details) Hessner et al. (2001)
85 ACE 17q23.3 Polish Non-significant (study details) Grzeszczak and Misztalski (2002)
53 ACE 17q23.3 French Non-significant (study details) Blanché et al. (2001)
90 ACE 17q23.3 Danish Significant (study details) Frederiksen et al. (2003)
63 ACE 17q23.3 Danish Non-significant (study details) Tan et al. (2001)
45 ACE 17q23.3 Dutch Non-significant (study details) Heijmans et al. (1999)
13 ACE 17q23.3 English (Cambridge) Significant (study details) Galinsky et al. (1997)
228 ACE 17q23.3 Italian Non-significant (study details) Nacmias et al. (2007)
123 ACE 17q23.3 Italian, French and Danish Non-significant (study details) Panza et al. (2003)
18 ACE 17q23.3 Danish Non-significant (study details) Agerholm-Larsen et al. (1997)
288 ACE 17q23.3 Chinese Significant (study details) Woo et al. (2012)
78 ACE 17q23.3 Chinese (Uighur, Kazakh and Han in Xinjiang) Significant (study details) Rahmutula et al. (2002)
37 ACE 17q23.3 Danish Non-significant (study details) Bladbjerg et al. (1999)
28 ACE 17q23.3 French Significant (study details) Faure-Delanef et al. (1998)
225 ACE 17q23.3 Columbian Significant (study details) Forero et al. (2006)
6 ACE 17q23.3 French Significant (study details) Schächter et al. (1994)
340 ACTN3 11q13.2 Spanish Non-significant (study details) Fiuza-Luces et al. (2011)
283 ADA 20q13.12 Italian (Central) Significant (study details) Napolioni et al. (2011)
240 ADA2 22q11.1 Italian Significant (study details) Napolioni and Lucarini (2010)
G432 ADARB1 21q22.3 Italian, Ashkenazi Jewish and Japanese Significant (study details, 5 variants) Sebastiani et al. (2009)
G433 ADARB2 10p15.3 Italian, Ashkenazi Jewish and Japanese Significant (study details, 13 variants) Sebastiani et al. (2009)
G549 ADIPOQ 3q27.3 Jordanian Non-significant (study details, 2 variants) Khabour et al. (2010)
281 ADIPOQ 3q27.3 Polish Significant (study details) Roszkowska-Gancarz et al. (2012)
242 ADIPOQ 3q27.3 Jordanian Significant (study details) Khabour et al. (2010)
G423 ADIPOQ 3q27.3 Ashkenazi Jewish Non-significant (study details, 3 variants) Atzmon et al. (2008)
G472 ADRB2 5q32 Chinese Significant (study details, 2 variants) Zhao et al. (2012)
3473 ADRB2 5q32 American (Caucasian) Significant (study details) Kulminski et al. (2010)
321 ADRB2 5q32 American (Caucasian) Non-significant (study details) Kulminski et al. (2010)
382 AGER 6p21.32 Caucasian Significant (study details) Falcone et al. (2013)
36 AGT 1q42.2 Danish Non-significant (study details) Bladbjerg et al. (1999)
64 AGT 1q42.2 Danish Significant (study details) Tan et al. (2001)
G497 AGTR1 3q24 Italian (Northern) and Japanese Significant (study details, 2 variants) Benigni et al. (2013)
100 AKAP10 17p11.2 American (Caucasian) Significant (study details) Kammerer et al. (2003)
255 AKT1 14q32.33 American (Caucasian) Significant (study details) Pawlikowska et al. (2009)
G474 AKT1 14q32.33 Danish, German Non-significant (study details, 5 variants) Nygaard et al. (2013)
289 AKT1 14q32.33 Danish, German Significant (study details) Nygaard et al. (2013)
91 APOA1 11q23.3 Italian (Southern) Significant (study details) Garasto et al. (2003)
3462 APOA4 11q23.3 Italian Significant (study details) Pepe et al. (1998)
92 APOA4 11q23.3 Italian (Southern) Non-significant (study details) Garasto et al. (2003)
24 APOA4 11q23.3 French Non-significant (study details) Merched et al. (1998)
2 APOB 2p24.1 Finnish Non-significant (study details) Louhija et al. (1994)
7 APOB 2p24.1 Finnish Significant (study details) Kervinen et al. (1994)
10 APOB 2p24.1 Italian Significant (study details) De Benedictis et al. (1997)
386 APOC1 19q13.32 European Significant (study details) Deelen et al. (2014)
12 APOC1 19q13.32 English (Cambridge) Significant (study details) Galinsky et al. (1997)
279 APOC1 19q13.32 European Significant (study details) Beekman et al. (2013)
52 APOC3 11q23.3 Russian Significant (study details) Anisimov et al. (2001)
89 APOC3 11q23.3 Italian (Southern) Non-significant (study details) Garasto et al. (2003)
213 APOC3 11q23.3 Ashkenazi Jewish Significant (study details) Atzmon et al. (2006)
4 APOC3 11q23.3 Finnish Significant (study details) Louhija et al. (1994)
G476 APOE 19q13.32 Danish, German, Dutch Significant (study details, 3 variants) Soerensen et al. (2013)
171 APOE 19q13.32 Ashkenazi Jewish (Jerusalem) Non-significant (study details) Stessman et al. (2005)
11 APOE 19q13.32 Italian Non-significant (study details) Ruiu et al. (1995)
G454 APOE 19q13.32 Danish Significant (study details, 2 variants) Lindahl-Jacobsen et al. (2013)
190 APOE 19q13.32 Chinese (Uighur in Xinjiang) Significant (study details) Mayila et al. (2005)
373 APOE 19q13.32 Irish (Belfast) Significant (study details) Rea et al. (2001)
131 APOE 19q13.32 Russian (Novosibirsk) Significant (study details) Shabalin et al. (2003)
99 APOE 19q13.32 Korean Non-significant (study details) Choi et al. (2003)
227 APOE 19q13.32 Columbian Non-significant (study details) Forero et al. (2006)
328 APOE 19q13.32 Italian Significant (study details) Malovini et al. (2011)
8 APOE 19q13.32 Finnish Significant (study details) Kervinen et al. (1994)
374 APOE 19q13.32 Chinese (Han) Significant (study details) Jian-Gang et al. (1998)
86 APOE 19q13.32 Brazilian Non-significant (study details) Schwanke et al. (2002)
68 APOE 19q13.32 Chinese (Uighur in Xinjiang) Significant (study details) Wang et al. (2001)
9 APOE 19q13.32 Swedish Significant (study details) Eggertsen et al. (1993)
224 APOE 19q13.32 Italian (Southern) Significant (study details) Seripa et al. (2006)
55 APOE 19q13.32 French Significant (study details) Blanché et al. (2001)
14 APOE 19q13.32 English (Cambridge) Non-significant (study details) Galinsky et al. (1997)
5 APOE 19q13.32 Finnish Significant (study details) Louhija et al. (1994)
229 APOE 19q13.32 Greek Significant (study details) Stakias et al. (2006)
51 APOE 19q13.32 Finnish Significant (study details) Frisoni et al. (2001)
248 APOE 19q13.32 American (Georgia and Louisiana populations from African and European origin) Significant (study details) Jazwinski et al. (2010)
G480 APOE 19q13.32 European and American (Caucasian) Significant (study details, 2 variants) McKay et al. (2011)
3476 APOE 19q13.32 French Significant (study details) Schächter et al. (1994)
323 ATM 11q22.3 Chinese (Han) Significant (study details) Chen et al. (2010)
357 ATM 11q22.3 Italian Significant (study details) Piaceri et al. (2013)
348 ATP8 Mt Japanese Significant (study details) Tanaka et al. (1998)
297 ATRIP 3p21.31 American (Caucasian) Significant (study details) Yashin et al. (2012)
77 BRCA1 17q21.31 American (Caucasians) and Italian Non-significant (study details) Vijg et al. (2001)
308 BTBD9 6p21.2 American (Caucasian) Significant (study details) Yashin et al. (2012)
33 C3 19p13.3 Italian Non-significant (study details) Bellavia et al. (1999)
35 C4A 6p21.33 Italian Non-significant (study details) Bellavia et al. (1999)
302 C7orf50 7p22.3 American (Caucasian) Significant (study details) Yashin et al. (2012)
300 CACNA1C 12p13.33 American (Caucasian) Significant (study details) Yashin et al. (2012)
326 CAMK4 5q22.1 Italian Significant (study details) Malovini et al. (2011)
299 CARS 11p15.4 American (Caucasian) Significant (study details) Yashin et al. (2012)
359 CASP5 11q22.3 Russian Significant (study details) Ulybina et al. (2010)
153 CAT 11p13 Danish Non-significant (study details) Christiansen et al. (2004)
G503 CCL5 17q12 Spanish Significant (study details, 2 variants) Laplana and Fibla (2012)
339 CCR5 3p21.31 Spanish Non-significant (study details) Laplana and Fibla (2012)
294 CDH4 20q13.33 American (Caucasian) Significant (study details) Yashin et al. (2012)
G434 CDKN1A 6p21.2 Italian Significant (study details, 2 variants) Gravina et al. (2009)
G430 CEP128 14q31.1 Ashkenazi Jewish Significant (study details, 2 variants) Atzmon et al. (2009)
185 CETP 16q13 Italian Non-significant (study details) Cellini et al. (2005)
G477 CETP 16q13 Danish, German, Dutch Significant (study details, 8 variants) Soerensen et al. (2013)
369 CETP 16q13 Ashkenazi Jewish Significant (study details) Atzmon et al. (2005)
95 CETP 16q13 Japanese Non-significant (study details) Arai et al. (2003)
128 CETP 16q13 Ashkenazi Jewish Significant (study details) Barzilai et al. (2003)
385 CETP 16q13 Chinese Non-significant (study details) Sun et al. (2014)
G521 CETP 16q13 American of Japanese origin Non-significant (study details, 2 variants) Koropatnick et al. (2008)
34 CFB 6p21.33 Italian Non-significant (study details) Bellavia et al. (1999)
236 CHIT1 1q32.1 Mediterranean (Italian, Greek and Tunisian) Significant (study details) Malaguarnera et al. (2010)
317 CLSTN2 3q23 American (Caucasian) Significant (study details) Yashin et al. (2012)
223 CNDP1 18q22.3 German Non-significant (study details) Zschocke et al. (2006)
186 CPB2 13q14.13 American (Caucasian) Significant (study details) Reiner et al. (2005)
113 CXCL8 4q13.3 Irish Non-significant (study details) Ross et al. (2003)
249 CYP19A1 15q21.2 Italian (Salerno) Significant (study details) Corbo et al. (2011)
48 CYP1A1 15q24.1 Italian (Northern) Non-significant (study details) Taioli et al. (2001)
G411 CYP1A1 15q24.1 German Non-significant (study details, 2 variants) Pesch et al. (2004)
145 CYP1B1 2p22.2 German Significant (study details) Pesch et al. (2004)
20 CYP2D6 22q13.2 Spanish Non-significant (study details) Agúndez et al. (1997)
G400 CYP2D6 22q13.2 French Non-significant (study details, 2 variants) Muiras et al. (1998)
22 CYP2E1 10q26.3 Spanish Non-significant (study details) Agúndez et al. (1997)
293 DRD4 11p15.5 American (Caucasian) Significant (study details) Grady et al. (2013)
G494 EGFR 7p11.2 Korean Significant (study details, 4 variants) Park et al. (2009)
234 ERCC2 19q13.32 Polish Significant (study details) Polosak et al. (2010)
250 ESR1 6q25.1-q25.2 Italian (Salerno) Significant (study details) Corbo et al. (2011)
G427 EXO1 1q43 German Significant (study details, 3 variants) Nebel et al. (2009)
61 F2 11p11.2 American (Caucasian) Non-significant (study details) Hessner et al. (2001)
65 F2 11p11.2 Danish Non-significant (study details) Tan et al. (2001)
38 F2 11p11.2 Danish Non-significant (study details) Bladbjerg et al. (1999)
56 F5 1q24.2 American (Caucasian) Non-significant (study details) Hessner et al. (2001)
66 F7 13q34 Danish Non-significant (study details) Tan et al. (2001)
39 F7 13q34 Danish Non-significant (study details) Bladbjerg et al. (1999)
172 F7 13q34 Ashkenazi Jewish (Jerusalem) Non-significant (study details) Stessman et al. (2005)
G404 F7 13q34 Danish Significant (study details, 2 variants) Tan et al. (2001)
15 F7 13q34 Italian Non-significant (study details) Mannucci et al. (1997)
318 FAM19A5 22q13.32 American (Caucasian) Significant (study details) Yashin et al. (2012)
82 FAS 10q23.31 Italian (Northern) Non-significant (study details) Pinti et al. (2002)
83 FASLG 1q24.3 Italian (Northern) Non-significant (study details) Pinti et al. (2002)
221 FCGR2A 1q23.3 German Non-significant (study details) Flesch et al. (2006)
16 FGB 4q31.3 Italian Non-significant (study details) Mannucci et al. (1997)
67 FGB 4q31.3 Danish Non-significant (study details) Tan et al. (2001)
40 FGB 4q31.3 Danish Non-significant (study details) Bladbjerg et al. (1999)
187 FGB 4q31.3 American (Caucasian) Non-significant (study details) Reiner et al. (2005)
G488 FOXO1 13q14.11 Chinese (Han) Significant (study details, 2 variants) Zeng et al. (2010)
119 FOXO1 13q14.11 Italian Non-significant (study details) Bonafè et al. (2003)
G428 FOXO1 13q14.11 Chinese (Han) Significant (study details, 2 variants) Li et al. (2009)
166 FOXO1 13q14.11 Japanese Non-significant (study details) Kojima et al. (2004)
G513 FOXO3 6q21 Danish Non-significant (study details, 6 variants) Soerensen et al. (2010)
G445 FOXO3 6q21 American of Japanese origin Non-significant (study details, 39 variants) Donlon et al. (2012)
G426 FOXO3 6q21 Italian (Southern) Significant (study details, 4 variants) Anselmi et al. (2009)
G460 FOXO3 6q21 Dutch Non-significant (study details, 21 variants) Deelen et al. (2011)
G442 FOXO3 6q21 American of Japanese origin Significant (study details, 3 variants) Willcox et al. (2008)
G489 FOXO3 6q21 Chinese (Han) Significant (study details, 3 variants) Zeng et al. (2010)
G448 FOXO3 6q21 American (Caucasian) Significant (study details, 2 variants) Pawlikowska et al. (2009)
G512 FOXO3 6q21 Danish Significant (study details, 8 variants) Soerensen et al. (2010)
G429 FOXO3 6q21 Chinese (Han) Significant (study details, 3 variants) Li et al. (2009)
335 FSHR 2p16.3 Italian (Southern) (study details) Corbo et al. (2013)
178 GH1 17q23.3 Dutch Significant (study details) van Heemst et al. (2005)
180 GHRHR 7p14.3 Dutch Non-significant (study details) van Heemst et al. (2005)
260 GHRHR 7p14.3 Danish Significant (study details) Soerensen et al. (2012)
271 GHRL 3p25.3 Danish Significant (study details) Soerensen et al. (2012)
262 GHSR 3q26.31 Danish Significant (study details) Soerensen et al. (2012)
142 GP1BA 17p13.2 Danish Non-significant (study details) Pesch et al. (2004)
365 GPX1 3p21.31 Danish Significant (study details) Soerensen et al. (2009)
259 GSR 8p12 Danish Significant (study details) Soerensen et al. (2012)
25 GSTM1 1p13.3 French Non-significant (study details) Muiras et al. (1998)
49 GSTM1 1p13.3 Italian (Northern) Non-significant (study details) Taioli et al. (2001)
146 GSTM1 1p13.3 German Non-significant (study details) Pesch et al. (2004)
211 GSTM1 1p13.3 Danish Non-significant (study details) Christiansen et al. (2006)
147 GSTP1 11q13.2 German Non-significant (study details) Pesch et al. (2004)
212 GSTT1 22q11.23 Danish Significant (study details) Christiansen et al. (2006)
148 GSTT1 22q11.23 German Non-significant (study details) Pesch et al. (2004)
50 GSTT1 22q11.23 Italian (Northern) Significant (study details) Taioli et al. (2001)
356 GSTZ1 14q24.3 Italian (Southern) Significant (study details) Di Cianni et al. (2013)
273 H2AFX 11q23.3 Danish Significant (study details) Soerensen et al. (2012)
G406 HFE 6p22.2 Italian (Sardinia) Non-significant (study details, 3 variants) Carru et al. (2003)
81 HFE 6p22.2 Italian (Sicily) Significant (study details) Lio et al. (2002)
370 HFE 6p22.2 Italian (Sicily) Significant (study details) Lio et al. (2002)
G520 HFE 6p22.2 Italian (Sicily) Non-significant (study details, 2 variants) Lio et al. (2002)
114 HLA-A 6p22.1 Irish (Belfast) Non-significant (study details) Ross et al. (2003)
133 HLA-A 6p22.1 Bulgarian Non-significant (study details) Naumova et al. (2004)
116 HLA-B 6p21.33 Irish (Belfast) Non-significant (study details) Ross et al. (2003)
135 HLA-B 6p21.33 Bulgarian Non-significant (study details) Naumova et al. (2004)
195 HLA-B 6p21.33 Mexican Non-significant (study details) Soto-Vega et al. (2005)
3 HLA-B 6p21.33 Dutch Non-significant (study details) Lagaay et al. (1991)
136 HLA-C 6p21.33 Bulgarian Non-significant (study details) Naumova et al. (2004)
196 HLA-DQA1 6p21.32 Mexican Non-significant (study details) Soto-Vega et al. (2005)
215 HLA-DQA1 6p21.32 Italian (Sardinia) Non-significant (study details) Scola et al. (2006)
376 HLA-DQA1 6p21.32 Japanese Significant (study details) Takata et al. (1987)
G397 HLA-DQA1 6p21.32 Japanese (Okinawa) Significant (study details, 2 variants) Akisaka et al. (1997)
G398 HLA-DQB1 6p21.32 Japanese (Okinawa) Significant (study details, 2 variants) Akisaka et al. (1997)
G408 HLA-DQB1 6p21.32 Bulgarian Non-significant (study details, 2 variants) Naumova et al. (2004)
216 HLA-DQB1 6p21.32 Italian (Sardinia) Non-significant (study details) Scola et al. (2006)
194 HLA-DRB1 6p21.32 Mexican Non-significant (study details) Soto-Vega et al. (2005)
377 HLA-DRB1 6p21.32 Japanese Significant (study details) Takata et al. (1987)
245 HLA-DRB1 6p21.32 Italian (Palermo) Significant (study details) Listì et al. (2010)
21 HLA-DRB1 6p21.32 French Significant (study details) Ivanova et al. (1998)
G399 HLA-DRB1 6p21.32 Japanese (Okinawa) Significant (study details, 3 variants) Akisaka et al. (1997)
G409 HLA-DRB1 6p21.32 Bulgarian Non-significant (study details, 2 variants) Naumova et al. (2004)
115 HLA-DRB3 6p21.3 Irish (Belfast) Non-significant (study details) Ross et al. (2003)
1 HLA-DRB5 6p21.32 Dutch Non-significant (study details) Lagaay et al. (1991)
93 HMOX1 22q12.3 Japanese Significant (study details) Yamaya et al. (2003)
352 HP 16q22.2 Italian (Central) Significant (study details) Napolioni et al. (2011)
309 HPCAL1 2p25.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
G478 HSPA14 10p13 Danish, German, Dutch Significant (study details, 4 variants) Soerensen et al. (2013)
125 HSPA1A 6p21.33 Italian (Southern) Significant (study details) Altomare et al. (2003)
217 HSPA1A 6p21.33 Danish Significant (study details) Singh et al. (2006)
149 HSPA1A 6p21.33 Danish Significant (study details) Singh et al. (2004)
219 HSPA1B 6p21.33 Danish Significant (study details) Singh et al. (2006)
378 HSPA1L 6p21.33 Irish Significant (study details) Ross et al. (2003)
150 HSPA1L 6p21.33 Danish Non-significant (study details) Singh et al. (2004)
106 HSPA1L 6p21.33 Irish Significant (study details) Ross et al. (2003)
372 IFNG 12q15 Italian Significant (study details) Lio et al. (2002)
108 IFNG 12q15 Irish Non-significant (study details) Ross et al. (2003)
137 IFNG 12q15 Bulgarian Non-significant (study details) Naumova et al. (2004)
160 IFNG 12q15 Italian (Sardinia) Non-significant (study details) Pes et al. (2004)
79 IFNG 12q15 Italian Significant (study details) Lio et al. (2002)
241 IGF1 12q23.2 Chinese (Han) Non-significant (study details) Xie et al. (2010)
232 IGF1 12q23.2 Ashkenazi Jewish Non-significant (study details) Suh et al. (2008)
179 IGF1 12q23.2 Dutch Non-significant (study details) van Heemst et al. (2005)
G424 IGF1 12q23.2 Chinese (Han) Non-significant (study details, 3 variants) Xie et al. (2008)
G407 IGF1R 15q26.3 Italian Significant (study details, 2 variants) Bonafè et al. (2003)
G422 IGF1R 15q26.3 Ashkenazi Jewish Significant (study details, 2 variants) Suh et al. (2008)
325 IGF1R 15q26.3 Italian Significant (study details) Albani et al. (2011)
173 IGF2 11p15.5 Ashkenazi Jewish (Jerusalem) Significant (study details) Stessman et al. (2005)
73 IGF2 11p15.5 Italian Non-significant (study details) De Luca et al. (2001)
264 IGF2R 6q25.3 Danish Significant (study details) Soerensen et al. (2012)
G410 IL10 1q32.1 Bulgarian Non-significant (study details, 3 variants) Naumova et al. (2004)
80 IL10 1q32.1 Italian Significant (study details) Lio et al. (2002)
199 IL10 1q32.1 Japanese Significant (study details) Okayama et al. (2005)
246 IL10 1q32.1 Jordanian Significant (study details) Khabour and Barnawi (2010)
109 IL10 1q32.1 Irish Non-significant (study details) Ross et al. (2003)
69 IL10 1q32.1 Finnish Non-significant (study details) Wang et al. (2001)
101 IL10 1q32.1 Italian Significant (study details) Lio et al. (2003)
161 IL10 1q32.1 Italian (Sardinia) Non-significant (study details) Pes et al. (2004)
110 IL12A 3q25.33 Irish Non-significant (study details) Ross et al. (2003)
200 IL18 11q23.1 Japanese Non-significant (study details) Okayama et al. (2005)
230 IL18 11q23.1 Italian Significant (study details) Frayling et al. (2007)
71 IL1A 2q14.1 Finnish Non-significant (study details) Wang et al. (2001)
105 IL1A 2q14.1 Italian (Nothern and Central) Non-significant (study details) Cavallone et al. (2003)
103 IL1B 2q14.1 Italian (Northern and Central) Non-significant (study details) Cavallone et al. (2003)
201 IL1B 2q14.1 Japanese Non-significant (study details) Okayama et al. (2005)
70 IL1B 2q14.1 Finnish Non-significant (study details) Wang et al. (2001)
72 IL1RN 2q14.1 Finnish Non-significant (study details) Wang et al. (2001)
104 IL1RN 2q14.1 Italian (Northern and Central) Non-significant (study details) Cavallone et al. (2003)
111 IL2 4q27 Irish Non-significant (study details) Ross et al. (2003)
207 IL2 4q27 Italian (Central and Southern) Non-significant (study details) Scola et al. (2005)
189 IL6 7p15.3 American (Caucasian) Non-significant (study details) Reiner et al. (2005)
107 IL6 7p15.3 Irish (Northern) Non-significant (study details) Rea et al. (2003)
57 IL6 7p15.3 Italian Significant (study details) Bonafè et al. (2001)
112 IL6 7p15.3 Irish Non-significant (study details) Ross et al. (2003)
176 IL6 7p15.3 Finnish Significant (study details) Hurme et al. (2005)
327 IL6 7p15.3 Italian Non-significant (study details) Albani et al. (2011)
163 IL6 7p15.3 Italian (Sardinia) Non-significant (study details) Pes et al. (2004)
291 IL6 7p15.3 Danish, German, Dutch Non-significant (study details) Soerensen et al. (2013)
154 IL6 7p15.3 Italian (Southern) Non-significant (study details) Capurso et al. (2004)
351 IL6 7p15.3 Turkish Significant (study details) Kayaaltı et al. (2011)
G524 IL6 7p15.3 Danish Significant (study details, 2 variants) Christiansen et al. (2004)
155 IL6 7p15.3 Danish Significant (study details) Christiansen et al. (2004)
74 IL6 7p15.3 Finnish Non-significant (study details) Wang et al. (2001)
202 IL6 7p15.3 Japanese Non-significant (study details) Okayama et al. (2005)
138 IL6 7p15.3 Bulgarian Non-significant (study details) Naumova et al. (2004)
G525 IL6 7p15.3 Danish Non-significant (study details, 2 variants) Christiansen et al. (2004)
G516 IL6R 1q21.3 American (Caucasian and African-American), Ashkenazi Jewish Non-significant (study details, 7 variants) Walston et al. (2009)
181 INS 11p15.5 Dutch Non-significant (study details) van Heemst et al. (2005)
76 INS 11p15.5 Italian Non-significant (study details) De Luca et al. (2001)
261 INS 11p15.5 Danish Significant (study details) Soerensen et al. (2012)
165 INSR 19p13.2 Japanese Significant (study details) Kojima et al. (2004)
167 IRS1 2q36.3 Japanese Non-significant (study details) Kojima et al. (2004)
183 IRS1 2q36.3 Dutch Non-significant (study details) van Heemst et al. (2005)
120 IRS1 2q36.3 Italian Non-significant (study details) Bonafè et al. (2003)
238 IRS2 13q34 Italian Significant (study details) Barbieri et al. (2010)
58 ITGA2 5q11.2 American (Caucasian) Non-significant (study details) Hessner et al. (2001)
59 ITGB3 17q21.32 American (Caucasian) Significant (study details) Hessner et al. (2001)
41 ITGB3 17q21.32 Danish Non-significant (study details) Bladbjerg et al. (1999)
159 KIR3DL1 19q13.42 Irish Non-significant (study details) Maxwell et al. (2004)
141 KIR3DL1 19q13.42 Irish Non-significant (study details) Ross et al. (2004)
258 KL 13q13.1 Danish Significant (study details) Soerensen et al. (2012)
368 KL 13q13.1 Ashkenazi Jewish, Czechs (Bohemian) Significant (study details) Arking et al. (2005)
233 KL 13q13.1 Italian Significant (study details) Invidia et al. (2010)
G405 KL 13q13.1 Czechs (Bohemian), Americans (Baltimore Caucasians and African-Americans) Significant (study details, 2 variants) Arking et al. (2002)
298 LINC01237 2q37.3 American (Caucasian) Significant (study details) Yashin et al. (2012)
389 LINC02227 5q33.3 European Significant (study details) Deelen et al. (2014)
96 LIPC 15q21.3 Japanese Non-significant (study details) Arai et al. (2003)
310 LOC100631378 19q13.13 American (Caucasian) Significant (study details) Yashin et al. (2012)
243 LOC105375494 7q32.1 Jordanian Significant (study details) Khabour et al. (2010)
354 LOC105378102 6q26 American (Amish) Significant (study details) Edwards et al. (2013)
274 LOC107987209 14q32.33 Dutch Significant (study details) Deelen et al. (2011)
97 LPL 8p21.3 Japanese Non-significant (study details) Arai et al. (2003)
117 LTA 6p21.33 Irish (Belfast) Non-significant (study details) Ross et al. (2003)
G496 LYN 8q12.1 Korean Significant (study details, 8 variants) Park et al. (2009)
358 MAP3K7 6q15 Italian (Southern) Significant (study details) Di Cianni et al. (2013)
G505 MEFV 16p13.3 Italian (Sicily) Non-significant (study details, 3 variants) Grimaldi et al. (2006)
197 MEFV 16p13.3 Italian (Sicily) Significant (study details) Grimaldi et al. (2006)
244 MINPP1 10q23.2 Caucasians Non-significant (study details) Newman et al. (2010)
272 MLH1 3p22.2 Danish Significant (study details) Soerensen et al. (2012)
G417 MLH1 3p22.2 Korean Significant (study details, 3 variants) Kim et al. (2006)
203 MMP1 11q22.2 Japanese Non-significant (study details) Okayama et al. (2005)
205 MMP3 11q22.2 Japanese Non-significant (study details) Okayama et al. (2005)
341 MSTN 2q32.2 Spanish and Italian Significant (study details) Garatachea et al. (2013)
G487 mt146T   Chinese (Guangxi Bama) Significant (study details, 2 variants) Yang et al. (2012)
220 MT1A 16q13 Italian Significant (study details) Cipriano et al. (2006)
350 MT2A 16q13 Turkish Significant (study details) Kayaaltı et al. (2011)
363 MTHFR 1p36.22 Jordanian Non-significant (study details) Khabour et al. (2009)
43 MTHFR 1p36.22 Danish Non-significant (study details) Bladbjerg et al. (1999)
17 MTHFR 1p36.22 English (Cambridge) Non-significant (study details) Galinsky et al. (1997)
174 MTHFR 1p36.22 Ashkenazi Jewish (Jerusalem) Non-significant (study details) Stessman et al. (2005)
60 MTHFR 1p36.22 American (Caucasian) Non-significant (study details) Hessner et al. (2001)
47 MTHFR 1p36.22 Swiss Non-significant (study details) Todesco et al. (1999)
143 MTHFR 1p36.22 Danish Non-significant (study details) Pesch et al. (2004)
193 MTR 1q43 German Significant (study details) Linnebank et al. (2005)
G518 MTTP 4q23 English (Oxford) Non-significant (study details, 11 variants) Neville et al. (2007)
G552 MTTP 4q23 Danish Non-significant (study details, 2 variants) Bathum et al. (2005)
G414 MTTP 4q23 German Non-significant (study details, 3 variants) Nebel et al. (2005)
G419 MTTP 4q23 Dutch Non-significant (study details, 2 variants) Beekman et al. (2006)
G401 NAT2 8p22 French Non-significant (study details, 4 variants) Muiras et al. (1998)
23 NAT2 8p22 Spanish Non-significant (study details) Agúndez et al. (1997)
304 NCAM2 21q21.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
346 ND2 Mt Japanese Significant (study details) Tanaka et al. (1998)
87 ND2 Mt Chinese Non-significant (study details) Yao et al. (2002)
345 ND5 Mt Chinese (Zhuang) Significant (study details) Feng et al. (2011)
G532 NDUFS1 2q33.3 Danish Significant (study details, 5 variants) Dato et al. (2014)
306 NLRC5 16q13 American (Caucasian) Significant (study details) Yashin et al. (2012)
338 NOS1 12q24.22 Italian (Southern) Significant (study details) Montesanto et al. (2013)
158 NR3C1 5q31.3 Dutch Significant (study details) van Rossum et al. (2004)
G420 NR3C1 5q31.3 Dutch Non-significant (study details, 3 variants) Kuningas et al. (2006)
G402 PARP1 1q42.12 French Non-significant (study details, 4 variants) Cottet et al. (2000)
27 PARP1 1q42.12 Italian Non-significant (study details) De Benedictis et al. (1998)
G515 PARP1 1q42.12 American (Caucasian and African-American), Ashkenazi Jewish Non-significant (study details, 2 variants) Walston et al. (2009)
303 PARVG 22q13.31 American (Caucasian) Significant (study details) Yashin et al. (2012)
G495 PAX4 7q32.1 Korean Significant (study details, 3 variants) Park et al. (2009)
G493 PCSK1 5q15 Korean Significant (study details, 3 variants) Park et al. (2009)
324 PICALM 11q14.2 Italian Significant (study details) Piaceri et al. (2011)
121 PIK3CB 3q22.3 Italian Non-significant (study details) Bonafè et al. (2003)
169 PIK3CB 3q22.3 Japanese Non-significant (study details) Kojima et al. (2004)
168 PIK3CG 7q22.3 Japanese Non-significant (study details) Kojima et al. (2004)
42 PLAT 8p11.21 Danish Non-significant (study details) Bladbjerg et al. (1999)
267 POLB 8p11.21 Danish Significant (study details) Soerensen et al. (2012)
84 PON1 7q21.3 Italian Significant (study details) Bonafè et al. (2002)
122 PON1 7q21.3 French Significant (study details) Xia et al. (2003)
151 PON1 7q21.3 Italian (Sicily) Significant (study details) Campo et al. (2004)
156 PON1 7q21.3 Danish Significant (study details) Christiansen et al. (2004)
134 PON1 7q21.3 Italian and N. Irish Significant (study details) Rea et al. (2004)
336 PPARG 3p25.2 Italian (Southern) Significant (study details) Corbo et al. (2013)
152 PPARG 3p25.2 Italian Significant (study details) Barbieri et al. (2004)
170 PPARGC1A 4p15.2 Japanese Non-significant (study details) Kojima et al. (2004)
315 PPP1R26-AS1 9q34.3 American (Caucasian) Significant (study details) Yashin et al. (2012)
305 PPP2R2C 4p16.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
329 PRNP 20p13 Polish Non-significant (study details) Golanska et al. (2013)
287 PTPN22 1p13.2 Italian (Central) Non-significant (study details) Napolioni et al. (2011)
265 RAD23B 9q31.2 Danish Significant (study details) Soerensen et al. (2012)
263 RAD52 12p13.33 Danish Significant (study details) Soerensen et al. (2012)
29 REN 1q32.1 Italian Non-significant (study details) De Benedictis et al. (1998)
349 RNR2 Mt Japanese Significant (study details) Tanaka et al. (1998)
G481 Rs10493513   American (Caucasian) (study details, 8 variants) Lunetta et al. (2007)
319 RUNX3 1p36.11 American (Caucasian) Significant (study details) Yashin et al. (2012)
G538 SDC4 20q13.12 Italian (Southern) Significant (study details, 2 variants) Rose et al. (2015)
226 SERPINE1 7q22.1 Italian (Sicily) Significant (study details) Listì et al. (2007)
144 SERPINE1 7q22.1 Danish Non-significant (study details) Pesch et al. (2004)
44 SERPINE1 7q22.1 Danish Non-significant (study details) Bladbjerg et al. (1999)
54 SERPINE1 7q22.1 German Non-significant (study details) Lottermoser et al. (2001)
46 SERPINE1 7q22.1 Dutch Non-significant (study details) Heijmans et al. (1999)
188 SERPINE1 7q22.1 American (Caucasian) Non-significant (study details) Reiner et al. (2005)
19 SERPINE1 7q22.1 Italian Significant (study details) Mannucci et al. (1997)
127 SHC1 1q21.3 Japanese Non-significant (study details) Kamei et al. (2003)
132 SHC1 1q21.3 Dutch Non-significant (study details) Mooijaart et al. (2004)
G540 SIRT1 10q21.3 Ashkenazi Jewish Non-significant (study details, 19 variants) Han et al. (2015)
G527 SIRT1 10q21.3 Dutch Non-significant (study details, 2 variants) Figarska et al. (2013)
G514 SIRT1 10q21.3 Chinese (Han) Significant (study details, 2 variants) Zhang et al. (2010)
251 SIRT1 10q21.3 American (Caucasian) Significant (study details) Kim et al. (2012)
379 SIRT1 10q21.3 Dutch Significant (study details) Figarska et al. (2013)
192 SIRT1 10q21.3 German Non-significant (study details) Flachsbart et al. (2006)
177 SIRT3 11p15.5 Italian (Southern) Significant (study details) Bellizzi et al. (2005)
G528 SIRT3 11p15.5 Italian (Northern) Non-significant (study details, 3 variants) Albani et al. (2014)
G542 SIRT3 11p15.5 Italian (Northern) Significant (study details, 2 variants) Albani et al. (2014)
388 SIRT3 11p15.5 Italian (Northern) Non-significant (study details) Albani et al. (2014)
129 SIRT3 11p15.5 Italian (Southern) Significant (study details) Rose et al. (2003)
292 SIRT6 19p13.3 Danish, German, Dutch Significant (study details) Soerensen et al. (2013)
124 SLC13A2 17q11.2 American Non-significant (study details) Lee et al. (2003)
334 SLC25A14 Xq26.1 Italian (Southern) Non-significant (study details) Rose et al. (2011)
333 SLC25A27 6p12.3 Italian (Southern) Significant (study details) Rose et al. (2011)
191 SLC6A4 17q11.2 Japanese Significant (study details) Gondo et al. (2005)
268 SLC9A3R2 16p13.3 Danish Significant (study details) Soerensen et al. (2012)
G529 SOD1 21q22.11 German Non-significant (study details, 3 variants) Gentschew et al. (2013)
364 SOD2 6q25.3 Danish Significant (study details) Soerensen et al. (2009)
31 SOD2 6q25.3 Italian Non-significant (study details) De Benedictis et al. (1998)
G533 SOD2 6q25.3 Danish Significant (study details, 5 variants) Dato et al. (2014)
G543 SOD2 6q25.3 German Non-significant (study details, 8 variants) Gentschew et al. (2013)
362 SOD2 6q25.3 Jordanian Non-significant (study details) Khabour et al. (2009)
184 SOD2 6q25.3 Dutch Non-significant (study details) van Heemst et al. (2005)
175 SOD2 6q25.3 Ashkenazi Jewish (Jerusalem) Non-significant (study details) Stessman et al. (2005)
G530 SOD3 4p15.2 German Non-significant (study details, 8 variants) Gentschew et al. (2013)
311 SSTR3 22q13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
301 STK24 13q32.2 American (Caucasian) Significant (study details) Yashin et al. (2012)
26 SULT1A1 16p11.2 English (Caucasian) and Nigerian Significant (study details) Coughtrie et al. (1999)
296 SVEP1 9q31.3 American (Caucasian) Significant (study details) Yashin et al. (2012)
337 TAS2R16 7q31.32 Italian (Southern) Significant (study details) Campa et al. (2012)
237 TERC 3q26.2 Ashkenazi Jewish Significant (study details) Atzmon et al. (2010)
286 TERT 5p15.33 Italian (Central) Significant (study details) Concetti et al. (2013)
239 TERT 5p15.33 Ashkenazi Jewish Significant (study details) Atzmon et al. (2010)
353 TFAM 10q21.1 Spanish Non-significant (study details) Santiago et al. (2013)
313 TGFA 2p13.3 American (Caucasian) Significant (study details) Yashin et al. (2012)
139 TGFB1 19q13.2 Bulgarian Non-significant (study details) Naumova et al. (2004)
206 TGFB1 19q13.2 Japanese Non-significant (study details) Okayama et al. (2005)
G413 TGFB1 19q13.2 Italian Significant (study details, 4 variants) Carrieri et al. (2004)
214 TGFB2 1q41 Italian (Sicily) Non-significant (study details) Nuzzo et al. (2006)
30 TH 11p15.5 Italian Significant (study details) De Benedictis et al. (1998)
254 TH 11p15.5 German Non-significant (study details) von Wurmb-Schwark et al. (2011)
88 TH 11p15.5 Italian Significant (study details) Tan et al. (2002)
231 TLR4 9q33.1 German Non-significant (study details) Nebel et al. (2007)
164 TLR4 9q33.1 Italian Significant (study details) Balistreri et al. (2004)
157 TNF 6p21.33 Danish Non-significant (study details) Bruunsgaard et al. (2004)
G517 TNF 6p21.33 Italian Significant (study details, 2 variants) Cardelli et al. (2008)
75 TNF 6p21.33 Finnish Non-significant (study details) Wang et al. (2001)
204 TNF 6p21.33 Japanese Non-significant (study details) Okayama et al. (2005)
140 TNF 6p21.33 Bulgarian Non-significant (study details) Naumova et al. (2004)
118 TNF 6p21.33 Irish (Belfast) Non-significant (study details) Ross et al. (2003)
247 TNF 6p21.33 Jordanian Non-significant (study details) Khabour and Barnawi (2010)
198 TNF 6p21.33 Mexican Significant (study details) Soto-Vega et al. (2005)
102 TNF 6p21.33 Italian Non-significant (study details) Lio et al. (2003)
331 TOMM40 19q13.32 Polish Significant (study details) Maruszak et al. (2012)
355 TOMM40 19q13.32 Danish, American Significant (study details) Schupf et al. (2013)
282 TOMM40 19q13.32 American (Caucasian) Significant (study details) Sebastiani et al. (2012)
360 TOMM40 19q13.32 American, English, Irish Significant (study details) Shi et al. (2012)
285 TP53 17p13.1 Italian (Central) Significant (study details) Di Pietro et al. (2013)
381 TP53 17p13.1 Danish Significant (study details) Bojesen and Nordestgaard (2008)
276 TP53 17p13.1 European Significant (study details) Beekman et al. (2013)
322 TP53 17p13.1 Chinese (Guangxi Bama) Non-significant (study details) Yang et al. (2012)
290 TP53 17p13.1 Chinese Non-significant (study details) Cai et al. (2009)
G522 TP53 17p13.1 Irish Significant (study details, 2 variants) Ross et al. (2001)
295 TP53 17p13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
391 TP53 17p13.1 Japanese Significant (study details) Pinós et al. (2014)
277 TP53 17p13.1 European Significant (study details) Beekman et al. (2013)
387 TP53 17p13.1 Spanish Significant (study details) Pinós et al. (2014)
G523 TP53 17p13.1 Irish Non-significant (study details, 2 variants) Ross et al. (2001)
314 TP53 17p13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
383 TP53 17p13.1 European (Danish, Finnish, South Italian and Greek) Significant (study details) Raule et al. (2014)
278 TP53 17p13.1 European Significant (study details) Beekman et al. (2013)
342 TP53 17p13.1 American (Utah) Non-significant (study details) Kerber et al. (2012)
3474 TP53 17p13.1 American (Caucasian) Non-significant (study details) Boyden and Kunkel (2010)
347 TP53 17p13.1 American (Utah) Non-significant (study details) Kerber et al. (2012)
361 TP53 17p13.1 Chinese (Han) Non-significant (study details) Pan et al. (2011)
320 TP53 17p13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
256 TP53 17p13.1 American (Caucasian) Significant (study details) Boyden and Kunkel (2010)
375 TP53 17p13.1 Italian Significant (study details) De Benedictis et al. (1999)
343 TP53 17p13.1 American (Utah) Non-significant (study details) Kerber et al. (2012)
366 TP53 17p13.1 Japanese Significant (study details) Bilal et al. (2008)
3475 TP53 17p13.1 American (Caucasian) Non-significant (study details) Boyden and Kunkel (2010)
284 TP53 17p13.1 American (Caucasian) Significant (study details) Puca et al. (2001)
380 TP53 17p13.1 Italian (Northern) Significant (study details) Emanuele et al. (2010)
371 TP53 17p13.1 Finnish Significant (study details) Niemi et al. (2003)
307 TP53 17p13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
330 TP53 17p13.1 English (Newcastle) Non-significant (study details) Collerton et al. (2013)
257 TP53 17p13.1 American (Caucasian) Non-significant (study details) Boyden and Kunkel (2010)
280 TP53 17p13.1 European Significant (study details) Beekman et al. (2013)
344 TP53 17p13.1 American (Utah) Non-significant (study details) Kerber et al. (2012)
312 TP53 17p13.1 American (Caucasian) Significant (study details) Yashin et al. (2012)
235 TSHB 1p13.2 Ashkenazi Jewish Non-significant (study details) Atzmon et al. (2009)
G531 TTR 18q12.1 Danish Significant (study details, 2 variants) Hornstrup et al. (2013)
269 TXNRD1 12q23.3 Danish Significant (study details) Soerensen et al. (2012)
G544 TXNRD1 12q23.3 Danish Significant (study details, 15 variants) Dato et al. (2014)
3472 UBE4B 1p36.22 Chinese Significant (study details) Sun et al. (2014)
384 UBE4B 1p36.22 Spanish Significant (study details) Garatachea et al. (2014)
G499 UCP1 4q31.1 Italian (Southern) Significant (study details, 2 variants) Rose et al. (2011)
332 UCP2 11q13.4 Italian (Southern) Significant (study details) Rose et al. (2011)
182 UCP2 11q13.4 Dutch Non-significant (study details) van Heemst et al. (2005)
G500 UCP3 11q13.4 Italian (Southern) Significant (study details, 2 variants) Rose et al. (2011)
G479 UCP3 11q13.4 Danish Significant (study details, 2 variants) Dato et al. (2012)
G534 UCP3 11q13.4 Danish Significant (study details, 4 variants) Dato et al. (2014)
G548 UCP3 11q13.4 Danish Non-significant (study details, 2 variants) Dato et al. (2012)
G437 VDR 12q13.11 Spanish Non-significant (study details, 5 variants) Laplana et al. (2010)
367 VEGFA 6p21.1 Italian (Northern) Significant (study details) Del Bo et al. (2008)
G416 WRN 8p12 Dutch Non-significant (study details, 3 variants) Kuningas et al. (2006)
G403 WRN 8p12 Finnish and Mexican Non-significant (study details, 2 variants) Castro et al. (2000)
32 WRN 8p12 Finnish, American, Mexican and Japanese Non-significant (study details) Castro et al. (1999)
266 WRN 8p12 Danish Significant (study details) Soerensen et al. (2012)
270 XDH 2p23.1 Danish Significant (study details) Soerensen et al. (2012)
G418 XRCC1 19q13.31 English Non-significant (study details, 2 variants) Wilding et al. (2006)
208 XRCC3 14q32.33 English Non-significant (study details) Wilding et al. (2006)
209 XRCC4 5q14.2 English Non-significant (study details) Wilding et al. (2006)
210 XRCC5 2q35 English Non-significant (study details) Wilding et al. (2006)
275 XRCC5 2q35 Danish Significant (study details) Soerensen et al. (2012)
252 XRCC6 22q13.2 American (Caucasian) Non-significant (study details) Kim et al. (2012)
218 YTHDF2 1p35.3 Italian Significant (study details) Cardelli et al. (2006)
G457 10 genes Multiple Dutch Significant (study details, 10 variants) Deelen et al. (2013)
G492 10 genes Multiple Korean Non-significant (study details, 11 variants) Park et al. (2009)
G508 119 genes Multiple Italian (Southern) Non-significant (study details, 316 variants) Di Cianni et al. (2013)
G475 12 genes Multiple Danish, German, Dutch Non-significant (study details, 68 variants) Soerensen et al. (2013)
G463 14 genes Multiple European Non-significant (study details, 14 variants) Walter et al. (2011)
G501 16 genes Multiple Italian (Southern) Non-significant (study details, 38 variants) Campa et al. (2012)
G469 164 genes Multiple American (Caucasian) Significant (study details, 281 variants) Sebastiani et al. (2012)
G519 2 genes Multiple American (Caucasian), French Non-significant (study details, 6 variants) Geesaman et al. (2003)
G471 2 genes Multiple Italian (Central) Significant (study details, 3 variants) Napolioni et al. (2011)
G425 2 genes Multiple German Significant (study details, 16 variants) Flachsbart et al. (2009)
G498 2 genes Multiple Italian (Northern) and Japanese Non-significant (study details, 8 variants) Benigni et al. (2013)
G450 2 genes Multiple German Significant (study details, 2 variants) Nebel et al. (2011)
G554 2 genes Multiple American (Georgia and Louisiana populations from African and European origin) Non-significant (study details, 2 variants) Jazwinski et al. (2010)
G535 2 genes Multiple Spanish Non-significant (study details, 2 variants) Garatachea et al. (2014)
G452 2 genes Multiple German Non-significant (study details, 2 variants) Nebel et al. (2011)
G504 2 genes Multiple American (Caucasian), Ashkenazi Jewish Non-significant (study details, 2 variants) Terry et al. (2006)
G421 2 genes Multiple Ashkenazi Jewish Non-significant (study details, 2 variants) Terry et al. (2006)
G440 2 genes Multiple American (Caucasians), Italian (Southern), French, Ashkenazi Jewish Significant (study details, 4 variants) Conneely et al. (2012)
G447 2 genes Multiple Greek Non-significant (study details, 3 variants) Kolovou et al. (2014)
G446 2 genes Multiple Ashkenazi Jewish Non-significant (study details, 2 variants) Han et al. (2013)
G545 2 genes Multiple Italian (Southern) Non-significant (study details, 9 variants) Rose et al. (2015)
G470 2 genes Multiple American (Caucasian) Non-significant (study details, 20 variants) Heckman et al. (2012)
G458 2 genes Multiple Dutch Significant (study details, 3 variants) Deelen et al. (2011)
G412 2 genes Multiple Italian (Northern) Significant (study details, 2 variants) Gaspari et al. (2003)
G456 20 genes Multiple Dutch Non-significant (study details, 30 variants) Beekman et al. (2010)
G459 21 genes Multiple Dutch Non-significant (study details, 57 variants) Deelen et al. (2011)
G511 22 genes Multiple American, English, Irish Non-significant (study details, 41 variants) Shi et al. (2012)
G453 25 genes Multiple German Non-significant (study details, 32 variants) Nebel et al. (2011)
G550 3 genes Multiple Italian Non-significant (study details, 31 variants) Gravina et al. (2009)
G486 3 genes Multiple Germany, Italian, Chinese (Han) Non-significant (study details, 32 variants) Kleindorp et al. (2011)
G438 3 genes Multiple American (Georgia and Louisiana populations from African and European origin) Significant (study details, 3 variants) Jazwinski et al. (2010)
G536 3 genes Multiple Italian Significant (study details, 3 variants) Garatachea et al. (2014)
G537 3 genes Multiple Japanese Significant (study details, 3 variants) Garatachea et al. (2014)
G466 3 genes Multiple European Non-significant (study details, 6 variants) Lescai et al. (2009)
G468 3 genes Multiple German Non-significant (study details, 3 variants) Flachsbart et al. (2010)
G462 3 genes Multiple Dutch Non-significant (study details, 3 variants) Noordam et al. (2012)
G436 3 genes Multiple Danish Significant (study details, 3 variants) Singh et al. (2010)
G431 3 genes Multiple Chinese (Uighur in Xinjiang) Significant (study details, 3 variants) Li et al. (2009)
G490 3 genes Multiple Italian Significant (study details, 4 variants) Barbieri et al. (2012)
G539 3 genes Multiple American Significant (study details, 10 variants) Kim et al. (2015)
G455 3 genes Multiple Danish Non-significant (study details, 6 variants) Soerensen et al. (2012)
G502 3 genes Multiple Italian (Southern) Non-significant (study details, 5 variants) Montesanto et al. (2013)
G507 3 genes Multiple American (Amish) Non-significant (study details, 23 variants) Edwards et al. (2013)
G441 3 genes Multiple American (Caucasians), Italian (Southern), French, Ashkenazi Jewish Non-significant (study details, 12 variants) Conneely et al. (2012)
G467 3 genes Multiple European Non-significant (study details, 10 variants) Lescai et al. (2009)
G491 36 genes Multiple Italian Non-significant (study details, 66 variants) Malovini et al. (2011)
G482 4 genes Multiple American (Caucasian) Non-significant (study details, 9 variants) Lunetta et al. (2007)
G473 4 genes Multiple Chinese Non-significant (study details, 14 variants) Zhao et al. (2012)
G443 4 genes Multiple American of Japanese origin Non-significant (study details, 12 variants) Willcox et al. (2008)
G509 4 genes Multiple Ashkenazi Jewish Significant (study details, 4 variants) Huffman et al. (2012)
G506 4 genes Multiple Spanish Non-significant (study details, 4 variants) Santiago et al. (2013)
G465 4 genes Multiple European Non-significant (study details, 4 variants) Lescai et al. (2009)
G526 4 genes Multiple American (Caucasian and African-American) Non-significant (study details, 10 variants) Reiner et al. (2013)
G547 40 genes Multiple Danish Non-significant (study details, 282 variants) Dato et al. (2014)
G461 40 genes Multiple Dutch Significant (study details, 40 variants) Passtoors et al. (2013)
G485 5 genes Multiple German Non-significant (study details, 56 variants) Flachsbart et al. (2011)
G444 5 genes Multiple American of Japanese origin Non-significant (study details, 15 variants) Morris et al. (2014)
G541 5 genes Multiple American of Japanese origin Non-significant (study details, 78 variants) Morris et al. (2015)
G435 58 genes Multiple Caucasians Non-significant (study details, 287 variants) Newman et al. (2010)
G451 7 genes Multiple German Non-significant (study details, 16 variants) Nebel et al. (2011)
G484 7 genes Multiple American (Caucasian) Non-significant (study details, 21 variants) Lunetta et al. (2007)
G449 7 genes Multiple American (Caucasian) Non-significant (study details, 16 variants) Pawlikowska et al. (2009)
G483 8 genes Multiple American (Caucasian) Non-significant (study details, 16 variants) Lunetta et al. (2007)
G464 8 genes Multiple European Non-significant (study details, 8 variants) Walter et al. (2011)
G510 9 genes Multiple American, English, Irish Non-significant (study details, 9 variants) Shi et al. (2012)
G546 91 genes Multiple Danish Non-significant (study details, 592 variants) Debrabant et al. (2014)
Reference: HAGR