All types of senescence

Aging and Senescence

Entrez Id	Gene Symbol	Method	Senescence Type	Effect on senescence	Cell Types	Cell Lines	Cancer Line
6714	SRC	Overexpression	Stress-induced	Inhibition	Fibrosarcoma	HT1080	Yes
604	BCL6	Overexpression	Replicative	Inhibition	B-cell	Primary cell	No
57332	CBX8	Overexpression	Replicative	Inhibition	Fibroblast	TIG-3	No
1019	CDK4	Overexpression	Replicative	Inhibition	Foreskin fibroblast	BJ	No
1021	CDK6	Overexpression	Replicative	Inhibition	Foreskin fibroblast	BJ	No
7913	DEK	Overexpression	Replicative	Inhibition	Foreskin keratinocyte	Primary cell	No
1746	DLX2	Overexpression	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90	No
2353	FOS	Overexpression	Replicative	Inhibition	Lung fibroblast	WI-38	No
3397	ID1	Overexpression	Replicative	Inhibition	Dermal endothelial, Umbilical vein endothelial	Primary cell	No
79923	NANOG	Overexpression	Replicative	Inhibition	Dermal fibroblast, Fibroblast	NIH3T3, Oct4-GiP	Yes
10783	NEK6	Overexpression	Replicative	Inhibition	Bladder cancer, Lung cancer	EJ, NCI-H1299	Yes
8493	PPM1D	Overexpression	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
27339	PRPF19	Overexpression	Replicative	Inhibition	Dermal fibroblast, Umbilical vein endothelial	Primary cell	No
5693	PSMB5	Overexpression	Replicative	Inhibition	Multipotent bone marrow stromal	Primary cell	No
6446	SGK1	Overexpression	Replicative	Inhibition	Umbilical vein endothelial	Primary cell	No
23411	SIRT1	Overexpression	Replicative	Inhibition	Lung fibroblast	2BS	No
7015	TERT	Overexpression	Replicative	Inhibition	Foreskin fibroblast, Retinal pigment epithelial	BJ, RPE-340	No
7114	TMSB4X	Overexpression	Replicative	Inhibition	Nucleus pulposus	Primary cell	No
7422	VEGFA	Overexpression	Replicative	Inhibition	Dermal endothelial	Primary cell	No
4101	MAGEA2	Overexpression	Oncogene-induced	Inhibition	Foreskin fibroblast	BJ	No
9759	HDAC4	Knockout, Overexpression	Replicative	Inhibition	Lung fibroblast	2BS	No
3309	HSPA5	Knockout, Overexpression	Stress-induced	Inhibition	Ovarian cancer	A2780	Yes
648	BMI1	Knockout, Overexpression	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast, Skin fibroblast	82-6, BJ, WI-38	No
672	BRCA1	Mutation	Stress-induced	Inhibition	Breast cancer	HBL100, HCC1937, MCF-7	Yes
47	ACLY	Knockout	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
472	ATM	Knockout	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, MRC-5, WI-38	No
84661	DPY30	Knockout	Replicative	Inhibition	Lung fibroblast	IMR-90	No
2539	G6PD	Knockout	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3768	KCNJ12	Knockout	Stress-induced	Inhibition	Breast cancer, Gastric cancer, Prostate cancer	DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47D	Yes
4609	MYC	Knockout	Oncogene-induced	Inhibition	Fibroblast	LF1	No
4780	NFE2L2	Knockout	Replicative	Inhibition	Lung fibroblast	HFL-1	No
5948	RBP2	Knockout	Replicative	Inhibition	Cervical cancer, Gastric cancer	AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa	Yes
6829	SUPT5H	Knockout	Oncogene-induced	Inhibition	Cervical cancer	HeLa	Yes
10460	TACC3	Knockout	Stress-induced	Inhibition	Breast cancer	MCF-7	Yes
7014	TERF2	Knockout	Replicative	Inhibition	Neuroblastoma	SH-SY5Y	Yes
7490	WT1	Knockout	Oncogene-induced	Inhibition	Lung cancer	NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727	Yes
7707	ZNF148	Knockout	Replicative	Inhibition	Lung cancer	NCI-H460	Yes
231	AKR1B1	Knockdown, Overexpression	Stress-induced	Inhibition	Keratinocyte	HaCat	Yes
23492	CBX7	Knockdown, Overexpression	Replicative	Inhibition	Keratinocyte, Lung fibroblast	Primary cell, WI-38	No
8087	FXR1	Knockdown, Overexpression	Replicative	Inhibition	Laryngeal cancer, Tongue cancer	CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B	Yes
55355	HJURP	Knockdown, Overexpression	Replicative	Inhibition	Dermal fibroblast, Umbilical vein endothelial	Primary cell	No
3316	HSPB2	Knockdown, Overexpression	Stress-induced	Inhibition	Breast epithelial	MCF-10A, MCF-7	No
3489	IGFBP6	Knockdown, Overexpression	Replicative	Inhibition	Fibroblast	Primary cell	No
4170	MCL1	Knockdown, Overexpression	Stress-induced	Inhibition	Colon cancer	HCT116	Yes
59277	NTN4	Knockdown, Overexpression	Stress-induced	Inhibition	Glioma	T98G, U-251MG, U-87MG, U-U118MG	Yes
23598	PATZ1	Knockdown, Overexpression	Replicative	Inhibition	Umbilical vein endothelial	Primary cell	No
11059	WWP1	Knockdown, Overexpression	Replicative	Inhibition	Lung fibroblast	2BS, WI-38	No
444	ASPH	Knockdown	Replicative	Inhibition	Liver cancer	FOCUS, HepG2, Huh7	Yes
55729	ATF7IP	Knockdown	Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
6790	AURKA	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
9531	BAG3	Knockdown	Replicative	Inhibition	Glioma, Laryngeal cancer	A172, HEp2	Yes
644	BLVRA	Knockdown	Stress-induced	Inhibition	Fibroblast	Primary cell	No
10950	BTG3	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90, WI-38	No
983	CDK1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
8099	CDK2AP1	Knockdown	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
1058	CENPA	Knockdown	Replicative	Inhibition	Lung fibroblast	TIG-3	No
1452	CSNK1A1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
1457	CSNK2A1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
8727	CTNNAL1	Knockdown	Replicative	Inhibition	Lung cancer, Squamous carcinoma	A549, OC2	Yes
54487	DGCR8	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
1660	DHX9	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5	No
80824	DUSP16	Knockdown	Replicative	Inhibition	Embryonic kidney, Liver cancer	HEK293FT, HepG2, PLC/PRF/5	Yes
1845	DUSP3	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
2021	ENDOG	Knockdown	Replicative	Inhibition	Endothelial	Primary cell	No
2042	EPHA3	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
2146	EZH2	Knockdown	Stress-induced	Inhibition	Gastric cancer	SGC-7901	Yes
2305	FOXM1	Knockdown	Replicative	Inhibition	Gallbladder cancer	GBC-SD	Yes
2309	FOXO3	Knockdown	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
2597	GAPDH	Knockdown	Replicative	Inhibition	Lung cancer	A549	Yes
2720	GLB1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3096	HIVEP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3146	HMGB1	Knockdown	Replicative	Inhibition	Lung cancer, Melanoma	A375, G361, NCI-H1299, SK-MEL-28	Yes
10765	KDM5B	Knockdown	Replicative	Inhibition	Colon cancer	Colo201, DLD1, HCT116	Yes
57650	KIAA1524	Knockdown	Replicative	Inhibition	Gastric cancer	AGS, BGC-823, HGC-27, KATO-III	Yes
9365	KL	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5, WI-38	No
9113	LATS1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
3958	LGALS3	Knockdown	Replicative	Inhibition	Gastric cancer	AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2	Yes
51474	LIMA1	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
4085	MAD2L1	Knockdown	Replicative	Inhibition	Breast epithelial, Lung fibroblast	IMR-90, MCF-10A	No
4116	MAGOH	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
55110	MAGOHB	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
5606	MAP2K3	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
11184	MAP4K1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
54708	5-Mar	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
4190	MDH1	Knockdown	Replicative	Inhibition	Dermal fibroblast, Lung fibroblast	IMR-90, Primary cell	No
4204	MECP2	Knockdown	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
4318	MMP9	Knockdown	Replicative	Inhibition	Medulloblastoma	DAOY	Yes
4638	MYLK	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
4750	NEK1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
64175	P3H1	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
25913	POT1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
5495	PPM1B	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
55170	PRMT6	Knockdown	Replicative	Inhibition	Breast cancer, Breast epithelial	MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3	Yes
10213	PSMD14	Knockdown	Replicative	Inhibition	Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer	A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75	Yes
5885	RAD21	Knockdown	Replicative	Inhibition	Breast cancer	MDA-MB-231	No
9978	RBX1	Knockdown	Replicative	Inhibition	Glioblastoma, Lung cancer	U87	Yes
10856	RUVBL2	Knockdown	Replicative	Inhibition	Kidney cancer	A498, KRC/Y	Yes
280636	SELENOH	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5	No
29843	SENP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
59343	SENP2	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
57337	SENP7	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
51548	SIRT6	Knockdown	Replicative	Inhibition	Chondrocyte	NHAC-kn	No
6495	SIX1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
9194	SLC16A7	Knockdown	Replicative	Inhibition	Colon cancer, Gastric cancer	DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480	Yes
6597	SMARCA4	Knockdown	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
23049	SMG1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
6615	SNAI1	Knockdown	Replicative	Inhibition	Prostate cancer	LNCaP, PC-3	Yes
6647	SOD1	Knockdown	Replicative	Inhibition	Lung fibroblast	WI-38, WI38-SV40	No
6909	TBX2	Knockdown	Replicative	Inhibition	Melanoma	B16	Yes
7012	TERC	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
7027	TFDP1	Knockdown	Replicative	Inhibition	Cervical cancer, Lung cancer, Lung fibroblast	A549, HeLa, WI-38	Yes
8741	TNFSF13	Knockdown	Replicative	Inhibition	Colon cancer	SW480	Yes
7175	TPR	Knockdown	Replicative	Inhibition	Cervical cancer, Melanoma, Osteosarcoma	A375, HeLa, U2OS	Yes
79054	TRPM8	Knockdown	Replicative	Inhibition	Pancreatic cancer	BxPC-3, PANC-1	Yes
7295	TXN	Knockdown	Replicative	Inhibition	Foreskin fibroblast	BJ, BJE-LT	No
7398	USP1	Knockdown	Oncogene-induced	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, WI-38	No
7472	WNT2	Knockdown	Replicative	Inhibition	Lung fibroblast	WI-38	No
7486	WRN	Knockdown	Oncogene-induced	Inhibition	Fibroblast, WRN syndrome fibroblast	AG00780, AG03141	Yes
10413	YAP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90, WI-38	No
64393	ZMAT3	Knockdown	Replicative	Inhibition	Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma	HEK293T, MCF-7, U2OS	Yes
Reference: HAGR