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| Gene Symbol (Name) | Description | Change gender | Age change starts | Age change ends | Tissues | Percentage change | P value | References |
| PNPLA5 (patatin-like phospholipase domain containing 5) | Using a linear mixed model, differential expression with age was identified in PNPLA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PODXL (podocalyxin-like) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PODXL and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| POGLUT1 (protein O-glucosyltransferase 1) | Using a linear mixed model, differential expression with age was identified in POGLUT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POGLUT1 (protein O-glucosyltransferase 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of POGLUT1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POLD4 (polymerase (DNA-directed), delta 4, accessory subunit) | Using a linear mixed model, differential expression with age was identified in POLD4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLDIP3 (polymerase (DNA-directed), delta interacting protein 3) | Male and Female | 22 | 73 | Skeletal Muscle | 5.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| POLE4 (polymerase (DNA-directed), epsilon 4, accessory subunit) | Using a linear mixed model, differential expression with age was identified in POLE4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLR1C (polymerase (RNA) I polypeptide C, 30kDa) | Using a linear mixed model, differential expression with age was identified in POLR1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Polr2b (polymerase (RNA) II (DNA directed) polypeptide B) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| POLR2H (polymerase (RNA) II (DNA directed) polypeptide H) | Using a linear mixed model, differential expression with age was identified in POLR2H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLR3GL (polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like) | Using a linear mixed model, differential expression with age was identified in POLR3GL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of POMGNT1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POMGNT2 (protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)) | Using a linear mixed model, differential expression with age was identified in POMGNT2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PON3 (paraoxonase 3) | Using a linear mixed model, differential expression with age was identified in PON3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PON3 (paraoxonase 3) | Male and Female | 27 | 92 | Kidney | -13.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| POPDC2 (popeye domain containing 2) | Using a linear mixed model, differential expression with age was identified in POPDC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Postn (periostin, osteoblast specific factor) | Male and Female | 3 | 23 | Hematological System | -39.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| POU3F1 (POU class 3 homeobox 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of POU3F1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POU4F3 (POU class 4 homeobox 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of POU4F3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| POU6F1 (POU class 6 homeobox 1) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PPARG (peroxisome proliferator-activated receptor gamma) | Using a linear mixed model, differential expression with age was identified in PPARG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ppbp (pro-platelet basic protein) | Male and Female | 2 | 26 | Lung | 11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Ppbp (pro-platelet basic protein) | Male and Female | 3 | 23 | Hematological System | -27.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Ppcdc (phosphopantothenoylcysteine decarboxylase) | Male and Female | 4 | 15 | Cochlea | 6.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| PPCS (phosphopantothenoylcysteine synthetase) | Using a linear mixed model, differential expression with age was identified in PPCS in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPIA (peptidylprolyl isomerase A (cyclophilin A)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIA (peptidylprolyl isomerase A (cyclophilin A)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIC (peptidylprolyl isomerase C (cyclophilin C)) | Using a linear mixed model, differential expression with age was identified in PPIC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPIC (peptidylprolyl isomerase C (cyclophilin C)) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIF (peptidylprolyl isomerase F) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIG (peptidylprolyl isomerase G (cyclophilin G)) | Using a linear mixed model, differential expression with age was identified in PPIG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | |||||
| Reference: Source: AmiGo 2 | ||||||||