|
Entrez ID |
Symbol |
Method Used To Cause Senescence |
Cell type |
Cell line |
Cancer Line |
|||
|
22848 |
AAK1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
51225 |
ABI3 |
Overexpression |
Colon cancer, Thyroid cancer |
ARO, WRO |
Yes |
|||
|
203054 |
ADCK5 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
183 |
AGT |
Knockout, Overexpression |
Vascular smooth muscle |
Primary cell |
No |
|||
|
247 |
ALOX15B |
Overexpression |
Prostate epithelial |
Primary cell |
No |
|||
|
367 |
AR |
Knockdown, Overexpression |
Hair follicular keratinocyte |
Primary cell |
No |
|||
|
10095 |
ARPC1B |
Overexpression |
Osteosarcoma |
SaOs-2 |
Yes |
|||
|
558 |
AXL |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
640 |
BLK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
29117 |
BRD7 |
Knockdown |
Foreskin fibroblast |
BJ |
No |
|||
|
857 |
CAV1 |
Knockdown |
Fibroblast |
Primary cell |
No |
|||
|
284119 |
CAVIN1 |
Knockdown, Overexpression |
Cervical cancer, Lung fibroblast |
HeLa, IMR-90, WI-38 |
No |
|||
|
595 |
CCND1 |
Overexpression |
Fibroblast |
Hs68, WI-38 |
No |
|||
|
5129 |
CDK18 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
1026 |
CDKN1A |
Knockout |
Fibroblast |
LF1 |
No |
|||
|
1027 |
CDKN1B |
Overexpression |
Lung fibroblast |
TIG-3 |
No |
|||
|
1028 |
CDKN1C |
Overexpression |
Liver cancer |
HepG2, SNU-398 |
Yes |
|||
|
1029 |
CDKN2A |
Overexpression |
Lung fibroblast |
TIG-3 |
No |
|||
|
55602 |
CDKN2AIP |
Overexpression |
Lung fibroblast |
MRC-5, TIG-1 |
No |
|||
|
1030 |
CDKN2B |
Overexpression |
Glioblastoma |
T98G, U-251MG, U-373MG |
Yes |
|||
|
1152 |
CKB |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
64506 |
CPEB1 |
Knockout, Overexpression |
Foreskin fibroblast, Lung fibroblast |
Primary cell, WI-38 |
No |
|||
|
3576 |
CXCL8 |
Overexpression |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90, WI-38 |
No |
|||
|
3491 |
CYR61 |
Overexpression |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90 |
No |
|||
|
1869 |
E2F1 |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
26298 |
EHF |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
54206 |
ERRFI1 |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
2130 |
EWSR1 |
Knockout |
Hematopoietic stem |
Primary cell |
No |
|||
|
10922 |
FASTK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
79791 |
FBXO31 |
Overexpression |
Breast cancer |
MCF-7 |
Yes |
|||
|
56287 |
GKN1 |
Overexpression |
Gastric cancer |
AGS, MKN1 |
Yes |
|||
|
2791 |
GNG11 |
Knockout, Overexpression |
Lung fibroblast |
TIG-7 |
No |
|||
|
2870 |
GRK6 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
3065 |
HDAC1 |
Overexpression |
Cervical cancer |
HeLa |
Yes |
|||
|
220296 |
HEPACAM |
Overexpression |
Breast cancer |
MCF-7 |
Yes |
|||
|
3101 |
HK3 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
3458 |
IFNG |
Overexpression |
Umbilical vein endothelial |
Primary cell |
No |
|||
|
3484 |
IGFBP1 |
Overexpression |
Breast cancer |
MCF-7 |
Yes |
|||
|
3488 |
IGFBP5 |
Knockout, Overexpression |
Umbilical vein endothelial |
Primary cell |
No |
|||
|
3552 |
IL1A |
Knockout |
Umbilical vein endothelial |
Primary cell |
No |
|||
|
3621 |
ING1 |
Overexpression |
Foreskin fibroblast |
Hs68 |
No |
|||
|
3622 |
ING2 |
Knockout, Overexpression |
Lung fibroblast |
MRC-5 |
No |
|||
|
3661 |
IRF3 |
Overexpression |
Foreskin fibroblast |
BJ |
No |
|||
|
3663 |
IRF5 |
Overexpression |
Li Fraumeni syndrome fibroblast |
MDAH041 |
Yes |
|||
|
3665 |
IRF7 |
Overexpression |
Li Fraumeni syndrome fibroblast |
MDAH041 |
Yes |
|||
|
3691 |
ITGB4 |
Knockdown |
Umbilical vein endothelial |
Primary cell |
No |
|||
|
3705 |
ITPK1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
3707 |
ITPKB |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
3984 |
LIMK1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
5604 |
MAP2K1 |
Overexpression |
Intestinal epithelial |
HIEC-6 |
No |
|||
|
5608 |
MAP2K6 |
Overexpression |
Osteosarcoma |
U2OS |
Yes |
|||
|
5609 |
MAP2K7 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
9064 |
MAP3K6 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
6885 |
MAP3K7 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
6300 |
MAPK12 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
22983 |
MAST1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
4145 |
MATK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
10445 |
MCRS1 |
Overexpression |
Foreskin fibroblast, Lung fibroblast, Mammary epithelial |
H184B5F5/M10, Hs68, IMR-90 |
No |
|||
|
126308 |
MOB3A |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
23515 |
MORC3 |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
10934 |
MORF4 |
Overexpression |
Fibrosarcoma |
A9, HT1080 |
Yes |
|||
|
4598 |
MVK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
10608 |
MXD4 |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
65220 |
NADK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
10397 |
NDRG1 |
Knockdown |
Liver cancer |
Hep3B, HepG2, Huh7, PLC/PRF/5 |
Yes |
|||
|
4814 |
NINJ1 |
Overexpression |
Hepatoma |
Huh7 |
Yes |
|||
|
50507 |
NOX4 |
Knockdown, Overexpression |
Breast epithelial, Lung fibroblast |
MCF-12A, TIG-3 |
No |
|||
|
9891 |
NUAK1 |
Knockout, Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
5015 |
OTX2 |
Overexpression |
Medulloblastoma |
D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2 |
Yes |
|||
|
10298 |
PAK4 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
55193 |
PBRM1 |
Knockdown |
Foreskin fibroblast |
BJ |
No |
|||
|
7703 |
PCGF2 |
Knockout, Overexpression |
Foreskin fibroblast, Lung fibroblast |
BJ, MRC-5, WI-38 |
No |
|||
|
149420 |
PDIK1L |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
5170 |
PDPK1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
23037 |
PDZD2 |
Overexpression |
Breast cancer, Liver cancer, Prostate cancer |
DU145 |
Yes |
|||
|
51588 |
PIAS4 |
Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
23533 |
PIK3R5 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
5315 |
PKM |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
22925 |
PLA2R1 |
Knockout, Overexpression |
Lung fibroblast |
IMR-90, WI-38 |
No |
|||
|
10654 |
PMVK |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
87178 |
PNPT1 |
Overexpression |
Melanoma |
FO-1, HO-1, MeWo |
Yes |
|||
|
5460 |
POU5F1 |
Overexpression |
Mesenchymal stromal |
Primary cell |
No |
|||
|
5580 |
PRKCD |
Knockdown, Overexpression |
Lung fibroblast |
TIG-1 |
No |
|||
|
5629 |
PROX1 |
Overexpression |
Liver cancer |
Hep3B, HepG2, Mahlavu, SK-HEP1 |
Yes |
|||
|
9232 |
PTTG1 |
Overexpression |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90, WI-38 |
No |
|||
|
6041 |
RNASEL |
Knockout, Overexpression |
Lung fibroblast |
WI-38 |
No |
|||
|
27330 |
RPS6KA6 |
Knockdown, Overexpression |
Colon cancer, Lung fibroblast |
IMR-90 |
No |
|||
|
861 |
RUNX1 |
Overexpression |
Foreskin fibroblast |
Hs68 |
No |
|||
|
5054 |
SERPINE1 |
Knockdown |
Foreskin fibroblast |
BJ, Primary cell |
No |
|||
|
150094 |
SIK1 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
23309 |
SIN3B |
Knockout, Overexpression |
Lung fibroblast |
IMR-90 |
No |
|||
|
64849 |
SLC13A3 |
Overexpression |
Lung fibroblast, Renal tubular |
MRC-5, WI-38 |
No |
|||
|
6598 |
SMARCB1 |
Overexpression |
Malignant rhabdoid tumor |
G-401 |
Yes |
|||
|
64750 |
SMURF2 |
Overexpression |
Foreskin fibroblast, Lung fibroblast, Skin fibroblast |
BJ, WI-38, WS1 |
No |
|||
|
8470 |
SORBS2 |
Overexpression |
Fibroblast, Keratinocyte |
Primary cell |
No |
|||
|
6657 |
SOX2 |
Overexpression |
Colon cancer, Embryonic kidney |
HCT116, HEK293T, WiDr |
Yes |
|||
|
6667 |
SP1 |
Overexpression |
Lung fibroblast |
2BS |
No |
|||
|
10927 |
SPIN1 |
Overexpression |
Cervical cancer |
HeLa |
Yes |
|||
|
8405 |
SPOP |
Knockdown, Overexpression |
Lung fibroblast |
IMR-90 |
No |
|||
|
6720 |
SREBF1 |
Overexpression |
Fibroblast |
Primary cell |
No |
|||
|
6777 |
STAT5B |
Overexpression |
Lung fibroblast |
IMR-90 |
No |
|||
|
282974 |
STK32C |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
83931 |
STK40 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
6850 |
SYK |
Overexpression |
Melanoma |
501-mel, A375, SK-MEL-28 |
Yes |
|||
|
7023 |
TFAP4 |
Overexpression |
Breast cancer, Retinal pigment epithelial |
hTERT-RPE, MCF-7 |
Yes |
|||
|
7041 |
TGFB1I1 |
Knockout, Overexpression |
Fibroblast |
KMST-6, SUSM-1 |
No |
|||
|
7098 |
TLR3 |
Overexpression |
Fibroblast, Keratinocyte |
Primary cell |
No |
|||
|
9966 |
TNFSF15 |
Knockout, Overexpression |
Endothelial progenitor |
Primary cell |
No |
|||
|
7150 |
TOP1 |
Knockout |
Lung fibroblast |
IMR-90, WI-38 |
No |
|||
|
8626 |
TP63 |
Knockout |
Foreskin fibroblast |
BJ |
No |
|||
|
7297 |
TYK2 |
Overexpression |
Embryonic kidney, Lung fibroblast |
HEK293T, IMR-90, MRC-5 |
No |
|||
|
27287 |
VENTX |
Knockdown, Overexpression |
Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma |
HEK293T, HeLa, IMR-90, Nalm16, U2OS |
Yes |
|||
|
51384 |
WNT16 |
Knockdown |
Lung fibroblast |
MRC-5 |
No |
|||
|
7538 |
ZFP36 |
Overexpression |
Cervical cancer |
HeLa |
Yes |
|||
|
8553 |
BHLHE40 |
Overexpression |
Breast cancer, Esophageal cancer |
EC9706, MCF-7 |
Yes |
|||
|
2626 |
GATA4 |
Knockdown, Overexpression |
Foreskin fibroblast, Lung fibroblast |
BJ, IMR-90 |
No |
|||
|
1432 |
MAPK14 |
Knockout |
Lung fibroblast |
MRC-5, WI-38 |
No |
|||
|
6787 |
NEK4 |
Knockdown |
Foreskin fibroblast |
BJ |
No |
|||
|
7157 |
TP53 |
Overexpression |
Bladder cancer |
EJ |
Yes |
|||
|
80019 |
UBTD1 |
Overexpression |
Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer |
AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16 |
Yes |
|||
| Reference: HAGR | ||||||||