Aging and Senescence

     Age associated human genes
HGNC Symbol HAGRID Common name Function(s) References Interactions
A2M 139 alpha-2-macroglobulin   5 21
ABL1 78 ABL proto-oncogene 1, non-receptor tyrosine kinase   5 69
ADCY5 255 adenylate cyclase 5   1 1
AGPAT2 187 1-acylglycerol-3-phosphate O-acyltransferase 2   3 0
AGTR1 264 angiotensin II receptor, type 1   5 2
AIFM1 135 apoptosis-inducing factor, mitochondrion-associated, 1   4 16
AKT1 35 v-akt murine thymoma viral oncogene homolog 1   45 91
APEX1 195 APEX nuclease (multifunctional DNA repair enzyme) 1   11 40
APOC3 102 apolipoprotein C-III   7 0
APOE 138 apolipoprotein E   28 11
APP 137 amyloid beta (A4) precursor protein   35 125
APTX 95 aprataxin   6 6
AR 110 androgen receptor   8 91
ARHGAP1 249 Rho GTPase activating protein 1   1 9
ARNTL 251 aryl hydrocarbon receptor nuclear translocator-like   11 16
ATF2 193 activating transcription factor 2   10 59
ATM 9 ATM serine/threonine kinase   42 75
ATP5O 146 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit   3 4
ATR 231 ATR serine/threonine kinase   7 49
BAK1 278 BCL2-antagonist/killer 1   3 11
BAX 119 BCL2-associated X protein   21 23
BCL2 69 B-cell CLL/lymphoma 2   30 47
BDNF 191 brain-derived neurotrophic factor   27 2
BLM 68 Bloom syndrome, RecQ helicase-like   15 45
BMI1 188 BMI1 proto-oncogene, polycomb ring finger   13 41
BRCA1 61 breast cancer 1, early onset   21 131
BRCA2 79 breast cancer 2, early onset   8 26
BSCL2 186 Berardinelli-Seip congenital lipodystrophy 2 (seipin)   3 0
BUB1B 197 BUB1 mitotic checkpoint serine/threonine kinase B   10 25
BUB3 240 BUB3 mitotic checkpoint protein   4 16
C1QA 287 complement component 1, q subcomponent, A chain   1 2
CACNA1A 133 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit   7 4
CAT 107 catalase   37 15
CCNA2 177 cyclin A2   3 39
CDC42 250 cell division cycle 42   2 24
CDK1 201 cyclin-dependent kinase 1   4 59
CDK7 299 cyclin-dependent kinase 7   0 33
CDKN1A 284 cyclin-dependent kinase inhibitor 1A (p21, Cip1)   7 70
CDKN2A 226 cyclin-dependent kinase inhibitor 2A   35 50
CDKN2B 288 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)   2 2
CEBPA 88 CCAAT/enhancer binding protein (C/EBP), alpha   14 35
CEBPB 89 CCAAT/enhancer binding protein (C/EBP), beta   9 55
CETP 262 cholesteryl ester transfer protein, plasma   7 0
CHEK2 247 checkpoint kinase 2   8 35
CISD2 265 CDGSH iron sulfur domain 2   2 8
CLOCK 252 clock circadian regulator   17 12
CLU 220 clusterin   16 35
CNR1 282 cannabinoid receptor 1 (brain)   4 0
COQ7 132 coenzyme Q7 homolog, ubiquinone (yeast)   11 1
CREB1 192 cAMP responsive element binding protein 1   15 49
CREBBP 64 CREB binding protein   11 123
CSNK1E 244 casein kinase 1, epsilon   7 17
CTF1 304 cardiotrophin 1   0 4
CTGF 206 connective tissue growth factor   3 4
CTNNB1 223 catenin (cadherin-associated protein), beta 1, 88kDa   16 102
DBN1 228 drebrin 1   4 20
DDIT3 203 DNA-damage-inducible transcript 3   4 19
DGAT1 291 diacylglycerol O-acyltransferase 1   0 1
DLL3 225 delta-like 3 (Drosophila)   12 0
E2F1 18 E2F transcription factor 1   14 52
EEF1A1 189 eukaryotic translation elongation factor 1 alpha 1   5 43
EEF1E1 266 eukaryotic translation elongation factor 1 epsilon 1   3 0
EEF2 103 eukaryotic translation elongation factor 2   5 36
EFEMP1 260 EGF containing fibulin-like extracellular matrix protein 1   3 2
EGF 48 epidermal growth factor   15 13
EGFR 40 epidermal growth factor receptor   13 145
EGR1 76 early growth response 1   5 22
EIF5A2 289 eukaryotic translation initiation factor 5A2   0 0
ELN 230 elastin   9 2
EMD 121 emerin   4 27
EP300 94 E1A binding protein p300   11 161
EPOR 52 Erythropoietin receptor   5 16
EPS8 267 epidermal growth factor receptor pathway substrate 8   5 11
ERBB2 41 erb-b2 receptor tyrosine kinase 2   9 41
ERCC1 149 excision repair cross-complementation group 1   13 8
ERCC2 11 excision repair cross-complementation group 2   19 16
ERCC3 104 excision repair cross-complementation group 3   10 22
ERCC4 261 excision repair cross-complementation group 4   7 6
ERCC5 109 excision repair cross-complementation group 5   5 10
ERCC6 92 excision repair cross-complementation group 6   16 32
ERCC8 12 excision repair cross-complementation group 8   10 16
ESR1 216 estrogen receptor 1   23 127
FAS 115 Fas cell surface death receptor   26 25
FEN1 114 flap structure-specific endonuclease 1   10 22
FGF21 293 fibroblast growth factor 21   0 0
FGF23 259 fibroblast growth factor 23   8 2
FGFR1 169 fibroblast growth factor receptor 1   8 15
FLT1 171 fms-related tyrosine kinase 1   3 8
FOS 50 FBJ murine osteosarcoma viral oncogene homolog   19 47
FOXM1 131 forkhead box M1   21 24
FOXO1 124 forkhead box O1   43 33
FOXO3 123 forkhead box O3   56 34
FOXO4 183 forkhead box O4   19 18
GCLC 237 glutamate-cysteine ligase, catalytic subunit   7 2
GCLM 238 glutamate-cysteine ligase, modifier subunit   6 4
GDF11 309 growth differentiation factor 11   0 0
GH1 26 growth hormone 1   66 4
GHR 1 growth hormone receptor   32 23
GHRH 2 growth hormone releasing hormone   14 2
GHRHR 222 growth hormone releasing hormone receptor   16 2
GPX1 153 glutathione peroxidase 1   27 4
GPX4 257 glutathione peroxidase 4   2 6
GRB2 122 growth factor receptor-bound protein 2   7 77
GRN 300 granulin   0 8
GSK3A 295 glycogen synthase kinase 3 alpha   0 26
GSK3B 97 glycogen synthase kinase 3 beta   7 67
GSR 154 glutathione reductase   12 7
GSS 155 glutathione synthetase   6 3
GSTA4 156 glutathione S-transferase alpha 4   8 1
GSTP1 157 glutathione S-transferase pi 1   13 9
GTF2H2 111 general transcription factor IIH, polypeptide 2, 44kDa   3 10
H2AFX 212 H2A histone family, member X   12 76
HBP1 196 HMG-box transcription factor 1   5 14
HDAC1 151 histone deacetylase 1   11 117
HDAC2 207 histone deacetylase 2   7 77
HDAC3 25 histone deacetylase 3   7 59
HELLS 101 helicase, lymphoid-specific   6 12
HESX1 184 HESX homeobox 1   4 4
HIC1 253 hypermethylated in cancer 1   2 9
HIF1A 65 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)   17 62
HMGB1 176 high mobility group box 1   9 30
HMGB2 178 high mobility group box 2   5 10
HOXB7 213 homeobox B7   5 14
HOXC4 214 homeobox C4   4 8
HRAS 38 Harvey rat sarcoma viral oncogene homolog   21 12
HSF1 125 heat shock transcription factor 1   23 31
HSP90AA1 74 heat shock protein 90kDa alpha (cytosolic), class A member 1   10 133
HSPA1A 160 heat shock 70kDa protein 1A   31 56
HSPA1B 161 heat shock 70kDa protein 1B   4 16
HSPA8 199 heat shock 70kDa protein 8   12 84
HSPA9 152 heat shock 70kDa protein 9 (mortalin)   4 40
HSPD1 159 heat shock 60kDa protein 1 (chaperonin)   6 52
HTRA2 294 HtrA serine peptidase 2   0 11
HTT 98 huntingtin   17 35
IFNB1 308 Interferon beta   0 1
IGF1 28 insulin-like growth factor 1 (somatomedin C)   118 8
IGF1R 15 insulin-like growth factor 1 receptor   36 34
IGF2 29 insulin-like growth factor 2   21 2
IGFBP2 279 insulin-like growth factor binding protein 2, 36kDa   1 2
IGFBP3 73 insulin-like growth factor binding protein 3   10 8
IKBKB 297 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta   0 53
IL2 46 interleukin 2   7 2
IL2RG 49 interleukin 2 receptor, gamma   2 6
IL6 144 interleukin 6   23 0
IL7 167 interleukin 7   6 2
IL7R 27 interleukin 7 receptor   5 4
INS 30 insulin   77 4
INSR 42 insulin receptor   33 26
IRS1 32 insulin receptor substrate 1   21 48
IRS2 34 insulin receptor substrate 2   16 26
JAK2 215 Janus kinase 2   9 49
JUN 172 jun proto-oncogene   22 101
JUND 45 jun D proto-oncogene   7 24
KCNA3 268 potassium channel, voltage gated shaker related subfamily A, member 3   6 2
KL 17 klotho   33 0
LEP 217 leptin   36 2
LEPR 218 leptin receptor   14 2
LMNA 14 lamin A/C   61 43
LMNB1 181 lamin B1   5 18
LRP2 134 low density lipoprotein receptor-related protein 2   2 8
MAP3K5 179 mitogen-activated protein kinase kinase kinase 5   4 29
MAPK14 168 mitogen-activated protein kinase 14   28 55
MAPK3 175 mitogen-activated protein kinase 3   12 39
MAPK8 163 mitogen-activated protein kinase 8   26 71
MAPK9 174 mitogen-activated protein kinase 9   16 33
MAPT 205 microtubule-associated protein tau   35 39
MAX 208 MYC associated factor X   5 31
MDM2 210 MDM2 proto-oncogene, E3 ubiquitin protein ligase   9 115
MED1 173 mediator complex subunit 1   2 25
MIF 290 macrophage migration inhibitory factor (glycosylation-inhibiting factor)   0 9
MLH1 243 mutL homolog 1   5 28
MSRA 127 methionine sulfoxide reductase A   11 0
MT-CO1 158 mitochondrially encoded cytochrome c oxidase I   5 1
MT1E 292 metallothionein 1E   0 0
MTOR 221 mechanistic target of rapamycin (serine/threonine kinase)   26 49
MXD1 209 MAX dimerization protein 1   2 14
MXI1 90 MAX interactor 1, dimerization protein   3 6
MYC 39 v-myc avian myelocytomatosis viral oncogene homolog   22 119
NBN 44 nibrin   22 38
NCOR1 43 nuclear receptor corepressor 1   6 60
NCOR2 276 nuclear receptor corepressor 2   1 52
NFE2L1 307 nuclear factor, erythroid 2-like 1   0 5
NFE2L2 283 nuclear factor, erythroid 2-like 2   7 36
NFKB1 82 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1   25 59
NFKB2 20 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)   24 17
NFKBIA 219 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha   9 42
NGF 31 nerve growth factor (beta polypeptide)   13 4
NGFR 37 nerve growth factor receptor   5 13
NOG 229 noggin   7 1
NR3C1 75 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)   14 69
NRG1 24 neuregulin 1   6 6
NUDT1 296 nudix (nucleoside diphosphate linked moiety X)-type motif 1   0 0
PAPPA 254 pregnancy-associated plasma protein A, pappalysin 1   8 2
PARP1 60 poly (ADP-ribose) polymerase 1   39 91
PCK1 248 phosphoenolpyruvate carboxykinase 1 (soluble)   2 8
PCMT1 162 protein-L-isoaspartate (D-aspartate) O-methyltransferase   5 20
PCNA 113 proliferating cell nuclear antigen   12 67
PDGFB 47 platelet-derived growth factor beta polypeptide   7 5
PDGFRA 285 platelet-derived growth factor receptor, alpha polypeptide   4 17
PDGFRB 51 platelet-derived growth factor receptor, beta polypeptide   4 23
PDPK1 87 3-phosphoinositide dependent protein kinase 1   4 11
PEX5 58 peroxisomal biogenesis factor 5   4 10
PIK3CA 286 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha   1 20
PIK3CB 36 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta   22 12
PIK3R1 185 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)   16 65
PIN1 62 peptidylprolyl cis/trans isomerase, NIMA-interacting 1   9 46
PLAU 10 plasminogen activator, urokinase   9 8
PLCG2 57 phospholipase C, gamma 2 (phosphatidylinositol-specific)   6 18
PMCH 242 pro-melanin-concentrating hormone   6 0
PML 96 promyelocytic leukemia   11 89
POLA1 204 polymerase (DNA directed), alpha 1, catalytic subunit   9 22
POLB 236 polymerase (DNA directed), beta   14 16
POLD1 118 polymerase (DNA directed), delta 1, catalytic subunit   11 14
POLG 72 polymerase (DNA directed), gamma   11 0
PON1 142 paraoxonase 1   10 2
POU1F1 4 POU class 1 homeobox 1   20 14
PPARA 55 peroxisome proliferator-activated receptor alpha   13 22
PPARG 263 peroxisome proliferator-activated receptor gamma   8 63
PPARGC1A 256 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha   15 30
PPM1D 246 protein phosphatase, Mg2+/Mn2+ dependent, 1D   1 4
PPP1CA 227 protein phosphatase 1, catalytic subunit, alpha isozyme   3 56
PRDX1 141 peroxiredoxin 1   4 29
PRKCA 99 protein kinase C, alpha   4 39
PRKCD 54 protein kinase C, delta   4 41
PRKDC 106 protein kinase, DNA-activated, catalytic polypeptide   16 89
PROP1 5 PROP paired-like homeobox 1   29 2
PSEN1 224 presenilin 1   18 15
PTEN 63 phosphatase and tensin homolog   16 46
PTGS2 198 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)   11 15
PTK2 166 protein tyrosine kinase 2   5 43
PTK2B 165 protein tyrosine kinase 2 beta   2 23
PTPN1 33 protein tyrosine phosphatase, non-receptor type 1   5 28
PTPN11 19 protein tyrosine phosphatase, non-receptor type 11   7 47
PYCR1 280 pyrroline-5-carboxylate reductase 1   1 2
RAD51 84 RAD51 recombinase   10 37
RAD52 147 RAD52 homolog, DNA repair protein   3 27
RAE1 241 ribonucleic acid export 1   2 12
RB1 120 retinoblastoma 1   46 96
RECQL4 128 RecQ helicase-like 4   11 8
RELA 143 v-rel avian reticuloendotheliosis viral oncogene homolog A   32 93
RET 56 ret proto-oncogene   4 15
RGN 145 regucalcin   6 2
RICTOR 303 RPTOR independent companion of MTOR, complex 2   0 20
RPA1 67 replication protein A1, 70kDa   5 73
S100B 70 S100 calcium binding protein B   7 7
SDHC 182 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa   5 4
SERPINE1 301 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1   0 3
SHC1 3 SHC (Src homology 2 domain containing) transforming protein 1   29 67
SIN3A 200 SIN3 transcription regulator family member A   3 34
SIRT1 150 sirtuin 1   82 95
SIRT3 275 sirtuin 3   4 12
SIRT6 239 sirtuin 6   15 28
SIRT7 269 sirtuin 7   3 38
SLC13A1 270 solute carrier family 13 (sodium/sulfate symporter), member 1   3 0
SNCG 140 synuclein, gamma (breast cancer-specific protein 1)   5 8
SOCS2 271 suppressor of cytokine signaling 2   7 12
SOD1 130 superoxide dismutase 1, soluble   45 29
SOD2 129 superoxide dismutase 2, mitochondrial   55 11
SP1 170 Sp1 transcription factor   13 93
SPRTN 302 SprT-like N-terminal domain   0 20
SQSTM1 298 sequestosome 1   0 49
SST 53 somatostatin   8 2
SSTR3 100 somatostatin receptor 3   2 2
STAT3 22 signal transducer and activator of transcription 3 (acute-phase response factor)   13 83
STAT5A 23 signal transducer and activator of transcription 5A   5 35
STAT5B 21 signal transducer and activator of transcription 5B   5 21
STK11 93 serine/threonine kinase 11   5 18
STUB1 245 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase   1 69
SUMO1 211 small ubiquitin-like modifier 1   6 49
SUN1 277 Sad1 and UNC84 domain containing 1   1 0
TAF1 180 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa   1 26
TBP 194 TATA box binding protein   6 45
TCF3 59 transcription factor 3   7 13
TERC 7 telomerase RNA component   34 2
TERF1 105 telomeric repeat binding factor (NIMA-interacting) 1   9 45
TERF2 116 telomeric repeat binding factor 2   18 43
TERT 8 telomerase reverse transcriptase   62 32
TFAP2A 190 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)   7 30
TFDP1 202 transcription factor Dp-1   4 14
TGFB1 91 transforming growth factor, beta 1   25 2
TNF 86 tumor necrosis factor   20 11
TOP1 83 topoisomerase (DNA) I   9 36
TOP2A 80 topoisomerase (DNA) II alpha   8 42
TOP2B 81 topoisomerase (DNA) II beta   8 24
TOP3B 148 topoisomerase (DNA) III beta   7 4
TP53 6 tumor protein p53   139 221
TP53BP1 274 tumor protein p53 binding protein 1   7 42
TP63 234 tumor protein p63   9 37
TP73 281 tumor protein p73   3 41
TPP2 273 tripeptidyl peptidase II   2 4
TRAP1 305 TNF receptor-associated protein 1   0 12
TRPV1 306 transient receptor potential cation channel subfamily V member 1   0 3
TXN 16 thioredoxin   15 30
UBB 66 ubiquitin B   8 10
UBE2I 85 ubiquitin-conjugating enzyme E2I   5 113
UCHL1 136 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)   6 22
UCP1 258 uncoupling protein 1 (mitochondrial, proton carrier)   5 0
UCP2 235 uncoupling protein 2 (mitochondrial, proton carrier)   22 2
UCP3 232 uncoupling protein 3 (mitochondrial, proton carrier)   22 2
VCP 71 valosin containing protein   3 83
VEGFA 77 vascular endothelial growth factor A   15 7
WRN 13 Werner syndrome, RecQ helicase-like   88 47
XPA 126 xeroderma pigmentosum, complementation group A   15 18
XRCC5 112 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)   24 69
XRCC6 117 X-ray repair complementing defective repair in Chinese hamster cells 6   19 79
YWHAZ 164 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta   3 59
ZMPSTE24 233 zinc metallopeptidase STE24   13 2

 

Entry selected based on evidence directly linking the gene product to ageing in humans
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing or showing the gene product to be an effector of genes related to ageing

Source: HAGR