Epiblast Enriched Genes

Symbol

Name

Standardized Value 

NANOG

Nanog homeobox

2.38238

BMP4

bone morphogenetic protein 4

1.95934

GATA6

GATA binding protein 6

1.93154

PRDM14

PR domain containing 14

1.8672

OTX2

orthodenticle homeobox 2

1.7879

POU5F1

POU class 5 homeobox 1

1.75774

CDX2

caudal type homeobox 2

1.69998

FGF4

fibroblast growth factor 4

1.68803

BMP8B

bone morphogenetic protein 8b

1.50575

KLF4

Kruppel-like factor 4 (gut)

1.50056

SOX2

SRY (sex determining region Y)-box 2

1.43801

SOX17

SRY (sex determining region Y)-box 17

1.42922

GATA4

GATA binding protein 4

1.40938

EOMES

eomesodermin

1.408

FGF5

fibroblast growth factor 5

1.4057

FOXH1

forkhead box H1

1.36769

ELF5

E74-like factor 5 (ets domain transcription factor)

1.35132

SOX3

SRY (sex determining region Y)-box 3

1.35041

POU5F1B

POU class 5 homeobox 1B

1.32777

FGF8

fibroblast growth factor 8 (androgen-induced)

1.29804

SLAIN1

SLAIN motif family, member 1

1.2913

FUT4

fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)

1.28009

SMAD2

SMAD family member 2

1.2671

LEFTY2

left-right determination factor 2

1.24253

ESRRB

estrogen-related receptor beta

1.23762

PRDM1

PR domain containing 1, with ZNF domain

1.20467

TFCP2L1

transcription factor CP2-like 1

1.19089

FOXA2

forkhead box A2

1.18157

NODAL

nodal growth differentiation factor

1.15894

EED

embryonic ectoderm development

1.15673

WNT3A

wingless-type MMTV integration site family, member 3A

1.14919

FGF1

fibroblast growth factor 1 (acidic)

1.12438

OTX1

orthodenticle homeobox 1

1.12261

PRTG

protogenin

1.12172

LEFTY1

left-right determination factor 1

1.11774

TGFB1

transforming growth factor, beta 1

1.11553

DTX4

deltex 4, E3 ubiquitin ligase

1.11066

MNX1

motor neuron and pancreas homeobox 1

1.10181

MAGEB16

melanoma antigen family B16

1.08501

DPPA3

developmental pluripotency associated 3

1.0625

DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta

1.05809

NOG

noggin

1.05413

CDH1

cadherin 1, type 1, E-cadherin (epithelial)

1.04928

PCSK6

proprotein convertase subtilisin/kexin type 6

1.03434

KLF2

Kruppel-like factor 2

1.03346

CHRD

chordin

1.02337

L1TD1

LINE-1 type transposase domain containing 1

0.99586

CDX4

caudal type homeobox 4

0.983688

SOX1

SRY (sex determining region Y)-box 1

0.964199

SHH

sonic hedgehog

0.955996

LAMC1

laminin, gamma 1 (formerly LAMB2)

0.939206

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

0.931051

TCF7L1

transcription factor 7-like 1 (T-cell specific, HMG-box)

0.926764

WNT3

wingless-type MMTV integration site family, member 3

0.918633

MYOD1

myogenic differentiation 1

0.906256

ARFRP1

ADP-ribosylation factor related protein 1

0.904127

TBX6

T-box 6

0.89732

SALL4

spalt-like transcription factor 4

0.891798

POFUT2

protein O-fucosyltransferase 2

0.891798

PRICKLE1

prickle homolog 1 (Drosophila)

0.890525

FNIP2

folliculin interacting protein 2

0.867263

SIN3A

SIN3 transcription regulator family member A

0.864734

IFITM3

interferon induced transmembrane protein 3

0.854629

HESX1

HESX homeobox 1

0.843286

COPS3

COP9 signalosome subunit 3

0.837414

FST

follistatin

0.834061

VPS52

vacuolar protein sorting 52 homolog (S. cerevisiae)

0.830709

LAMA1

laminin, alpha 1

0.829453

DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha

0.82736

PCSK5

proprotein convertase subtilisin/kexin type 5

0.81983

ECSIT

ECSIT signalling integrator

0.819412

KIF16B

kinesin family member 16B

0.816068

LHX1

LIM homeobox 1

0.813562

INHBA

inhibin, beta A

0.812726

CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

0.812309

FURIN

furin (paired basic amino acid cleaving enzyme)

0.807299

DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

0.807299

SMAD4

SMAD family member 4

0.806465

FGF3

fibroblast growth factor 3

0.80563

FGF2

fibroblast growth factor 2 (basic)

0.805213

SETD1B

SET domain containing 1B

0.801876

FN1

fibronectin 1

0.78938

ADD3

adducin 3 (gamma)

0.786052

HS3ST5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

0.783557

FNIP1

folliculin interacting protein 1

0.783141

KDM7A

lysine (K)-specific demethylase 7A

0.781478

TBX3

T-box 3

0.778155

FAM3B

family with sequence similarity 3, member B

0.776909

NUP133

nucleoporin 133kDa

0.77027

GDF3

growth differentiation factor 3

0.747102

CDH2

cadherin 2, type 1, N-cadherin (neuronal)

0.747102

SMAD5

SMAD family member 5

0.743801

DIDO1

death inducer-obliterator 1

0.742152

PLET1

placenta expressed transcript 1

0.736382

GBX2

gastrulation brain homeobox 2

0.726097

FOXRED1

FAD-dependent oxidoreductase domain containing 1

0.71583

SFMBT2

Scm-like with four mbt domains 2

0.685143

IGF2R

insulin-like growth factor 2 receptor

0.685143

FGFR2

fibroblast growth factor receptor 2

0.684735

DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

0.682695

GINS4

GINS complex subunit 4 (Sld5 homolog)

0.65543

ACVR1B

activin A receptor, type IB

0.644479

PITX2

paired-like homeodomain 2

0.642048

HOXA1

homeobox A1

0.639214

TET1

tet methylcytosine dioxygenase 1

0.631123

CBX1

chromobox homolog 1

0.629506

ASTL

astacin-like metallo-endopeptidase (M12 family)

0.627889

FOXD3

forkhead box D3

0.625869

ETS2

v-ets avian erythroblastosis virus E26 oncogene homolog 2

0.623043

CNOT1

CCR4-NOT transcription complex, subunit 1

0.621831

BPTF

bromodomain PHD finger transcription factor

0.619814

STAG3

stromal antigen 3

0.617393

CTBP1

C-terminal binding protein 1

0.61578

TRO

trophinin

0.615377

DAG1

dystroglycan 1 (dystrophin-associated glycoprotein 1)

0.614571

KMT2B

lysine (K)-specific methyltransferase 2B

0.609332

DKK1

dickkopf WNT signaling pathway inhibitor 1

0.606916

RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

0.602892

CUBN

cubilin (intrinsic factor-cobalamin receptor)

0.602088

PROM1

prominin 1

0.599675

KDM1B

lysine (K)-specific demethylase 1B

0.597263

GDF11

growth differentiation factor 11

0.590036

CBX5

chromobox homolog 5

0.585224

PIGB

phosphatidylinositol glycan anchor biosynthesis, class B

0.583621

CTBP2

C-terminal binding protein 2

0.58282

POU3F1

POU class 3 homeobox 1

0.576816

LIFR

leukemia inhibitory factor receptor alpha

0.574816

WLS

wntless Wnt ligand secretion mediator

0.573616

MESDC2

mesoderm development candidate 2

0.571619

ZSCAN4

zinc finger and SCAN domain containing 4

0.571619

TRIM33

tripartite motif containing 33

0.569222

MEOX2

mesenchyme homeobox 2

0.568823

WNT1

wingless-type MMTV integration site family, member 1

0.556865

CRB2

crumbs family member 2

0.550503

RLIM

ring finger protein, LIM domain interacting

0.548914

TGIF1

TGFB-induced factor homeobox 1

0.546136

B3GAT1

beta-1,3-glucuronyltransferase 1

0.545342

ASCL2

achaete-scute family bHLH transcription factor 2

0.544549

DLK1

delta-like 1 homolog (Drosophila)

0.543359

EZH2

enhancer of zeste 2 polycomb repressive complex 2 subunit

0.539396

HIST2H2BF

histone cluster 2, H2bf

0.538604

HIST3H2BB

histone cluster 3, H2bb

0.538604

HIST1H2BH

histone cluster 1, H2bh

0.538209

HIST1H2BD

histone cluster 1, H2bd

0.537021

CUL4B

cullin 4B

0.535833

ACTC1

actin, alpha, cardiac muscle 1

0.53346

HIST1H2BA

histone cluster 1, H2ba

0.53267

METRN

meteorin, glial cell differentiation regulator

0.530693

HIST1H2BC

histone cluster 1, H2bc

0.518859

HIST1H2BF

histone cluster 1, H2bf

0.518859

RYBP

RING1 and YY1 binding protein

0.518465

BMPR1A

bone morphogenetic protein receptor, type IA

0.517678

GMNN

geminin, DNA replication inhibitor

0.51571

TGIF2

TGFB-induced factor homeobox 2

0.505102

KDM5B

lysine (K)-specific demethylase 5B

0.503141

SOX15

SRY (sex determining region Y)-box 15

0.499615

SNAI2

snail family zinc finger 2

0.489057

ACVR1

activin A receptor, type I

0.487886

TET2

tet methylcytosine dioxygenase 2

0.486326

HOXB1

homeobox B1

0.483596

BYSL

bystin-like

0.482817

NES

nestin

0.48087

CER1

cerberus 1, DAN family BMP antagonist

0.470763

CHURC1

churchill domain containing 1

0.4634

EGOT

eosinophil granule ontogeny transcript (non-protein coding)

0.460305

HOXD8

homeobox D8

0.459918

RBPJL

recombination signal binding protein for immunoglobulin kappa J region-like

0.457987

HOXB7

homeobox B7

0.456055

CHD3

chromodomain helicase DNA binding protein 3

0.456055

CDC45

cell division cycle 45

0.451042

ABR

active BCR-related

0.450657

HIST2H3PS2

histone cluster 2, H3, pseudogene 2

0.444499

H3F3A

H3 histone, family 3A

0.43989

H3F3B

H3 histone, family 3B (H3.3B)

0.43989

FGFR1

fibroblast growth factor receptor 1

0.423436

RANGAP1

Ran GTPase activating protein 1

0.422673

QRSL1

glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1

0.420766

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

0.419623

NR5A2

nuclear receptor subfamily 5, group A, member 2

0.408592

ROCK2

Rho-associated, coiled-coil containing protein kinase 2

0.407832

KLF5

Kruppel-like factor 5 (intestinal)

0.40025

GJB5

gap junction protein, beta 5, 31.1kDa

0.399114

E2F6

E2F transcription factor 6

0.399114

POMT2

protein-O-mannosyltransferase 2

0.398357

DNMT1

DNA (cytosine-5-)-methyltransferase 1

0.395709

LAMB1

laminin, beta 1

0.395331

CCR4

chemokine (C-C motif) receptor 4

0.394576

BHLHA15

basic helix-loop-helix family, member a15

0.391931

FERMT2

fermitin family member 2

0.38665

TENM1

teneurin transmembrane protein 1

0.375368

NANOS3

nanos homolog 3 (Drosophila)

0.373118

WNT9A

wingless-type MMTV integration site family, member 9A

0.36825

TCF4

transcription factor 4

0.364886

DTX1

deltex 1, E3 ubiquitin ligase

0.361901

TDGF1

teratocarcinoma-derived growth factor 1

0.360036

TRIM28

tripartite motif containing 28

0.358919

FMN1

formin 1

0.358174

TBX5

T-box 5

0.35743

CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

0.354826

HOXB6

homeobox B6

0.348519

MYF5

myogenic factor 5

0.348519

PGK1

phosphoglycerate kinase 1

0.348148

PAX3

paired box 3

0.347038

GLB1

galactosidase, beta 1

0.340757

AMOT

angiomotin

0.340388

BMP2

bone morphogenetic protein 2

0.337808

POMT1

protein-O-mannosyltransferase 1

0.331927

SETDB1

SET domain, bifurcated 1

0.325335

INHBB

inhibin, beta B

0.324239

CBX3

chromobox homolog 3

0.324239

ZIC3

Zic family member 3

0.311507

ZEB2

zinc finger E-box binding homeobox 2

0.310783

PAK4

p21 protein (Cdc42/Rac)-activated kinase 4

0.307528

PCGF2

polycomb group ring finger 2

0.307167

UTF1

undifferentiated embryonic cell transcription factor 1

0.306083

TRIM47

tripartite motif containing 47

0.305722

PORCN

porcupine homolog (Drosophila)

0.302478

FZD5

frizzled class receptor 5

0.294939

TFAP2C

transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

0.294223

CUL4A

cullin 4A

0.293151

TLN1

talin 1

0.292793

FZD8

frizzled class receptor 8

0.287803

TBX20

T-box 20

0.287447

SBDS

Shwachman-Bodian-Diamond syndrome

0.287447

ALPPL2

alkaline phosphatase, placental-like 2

0.286381

ALPL

alkaline phosphatase, liver/bone/kidney

0.286026

ALPP

alkaline phosphatase, placental

0.285316

TBX4

T-box 4

0.284962

EPHB3

EPH receptor B3

0.280012

FZD10

frizzled class receptor 10

0.278603

INA

internexin neuronal intermediate filament protein, alpha

0.277197

WWTR1

WW domain containing transcription regulator 1

0.276846

AKAP17A

A kinase (PRKA) anchor protein 17A

0.271952

DES

desmin

0.271604

TJP3

tight junction protein 3

0.268137

CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

0.263669

ICAM5

intercellular adhesion molecule 5, telencephalin

0.262304

SHC4

SHC (Src homology 2 domain containing) family, member 4

0.260606

GFAP

glial fibrillary acidic protein

0.253578

PINK1

PTEN induced putative kinase 1

0.249653

HMX2

H6 family homeobox 2

0.247719

CDT1

chromatin licensing and DNA replication factor 1

0.24676

CYTH1

cytohesin 1

0.242054

DOCK1

dedicator of cytokinesis 1

0.237513

CNBP

CCHC-type zinc finger, nucleic acid binding protein

0.23459

HDAC9

histone deacetylase 9

0.234302

CXCR4

chemokine (C-X-C motif) receptor 4

0.232881

FGF17

fibroblast growth factor 17

0.232599

SMAD9

SMAD family member 9

0.232317

NID1

nidogen 1

0.231482

PRMT5

protein arginine methyltransferase 5

0.229299

POU3F2

POU class 3 homeobox 2

0.228497

FZD7

frizzled class receptor 7

0.227707

BIK

BCL2-interacting killer (apoptosis-inducing)

0.2259

HAND1

heart and neural crest derivatives expressed 1

0.225647

DDX4

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

0.225395

SFRP5

secreted frizzled-related protein 5

0.224893

KRT8

keratin 8, type II

0.223419

DVL2

dishevelled segment polarity protein 2

0.223419

GSK3B

glycogen synthase kinase 3 beta

0.219928

PIK3C3

phosphatidylinositol 3-kinase, catalytic subunit type 3

0.219928

VANGL2

VANGL planar cell polarity protein 2

0.219047

NOTCH1

notch 1

0.21883

SOX10

SRY (sex determining region Y)-box 10

0.218613

KLHL2

kelch-like family member 2

0.218398

GRIP1

glutamate receptor interacting protein 1

0.217762

MIR203A

microRNA 203a

0.214576

 

Source: Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford). 2016 Jul 3;2016. pii: baw100.