Aging and Senescence

     Age induced physiological changes
Identifier Name Data Tissues Organism Actions
DAA905 Ability to secrete acid load decreases — kidney Human  
DAA814 Abnormal labored breathing index — respiratory system Human  
DAA723 Accumulation of extracellular neuritic plaques — brain Human  
DAA722 Accumulation of neuromelanin in dopaminergic nigral neurons — substantia nigra Human  
DAA2591 Advanced glycation end products increases in aging human skeletal muscle — muscle Human  
DAA1978 Age differences in classical conditioning of the eyelid response — eyelid Human  
DAA804 Air flow resistance increases — lung Human  
DAA698 Albumin levels decrease — plasma Human  
DAA912 Aldosterone secretion, blood levels and clearance decrease — plasma, adrenal gland Human  
DAA2035 Alterations in frequency, developmental potential and gene expression profile in hematopoietic stem cells — hematopoietic stem cells Human  
DAA2033 Alterations in structural proteins and cell membranes in the lenses — lens Human  
DAA2041 Altered brain mitochondrial metabolism — brain Human  
DAA2054 Altered cardiovascular response during heating — cardiovascular system Human  
DAA2031 Altered concentration of sodium, potassium and calcium — lens Human  
DAA815 Alveolar duct size increases — alveolus Human  
DAA797 Alveoli's ability decreases — alveolus Human  
DAA680 Aortic pulse wave velocity increases — aorta Human  
DAA979 Apoptotic pathway in response to stimuli disrupted — neutrophil Human  
DAA679 Arterial rigidity gradually increases — artery Human  
DAA692 Arteriosclerosis — artery Human  
DAA845 Atrophy of all four layers of large intestine — large intestine Human  
DAA1001 Atrophy of hypodermal layer — subcutaneous Human  
DAA839 Atrophy of mucosal lining in small intestine — small intestine Human  
DAA2051 Attenuated vasoconstriction response to cold — skin Human  
DAA727 Axon loss — white matter Human
DAA2023 Basal heat production decreases — whole body Human  
DAA2025 Basal oxygen uptake per kilogram of body water unchanged — whole body Human  
DAA895 Basement membranes of glomeruli and tubules thicken — renal tubule, glomerulus Human  
DAA2586 Benign prostatic hyperplasia — prostate Human  
DAA1996 Beta-amyloid protein deposition increases — brain Human  
DAA675 Beta-galactosidase expression increases in mesenchymal stem cells — mesenchymal stem cell Human  
DAA696 Blood cholesterol increases — plasma Human  
DAA1060 Blood flow to liver decreases — liver Human  
DAA1209 Blood IL6 level increase — plasma Human  
DAA2017 Blood sugar changes — plasma Human  
DAA1208 Blood TNF-alpha level increase — plasma Human  
DAA2018 Blood volume per unit of body weight unchanged — blood Human  
DAA940 B naive cells' susceptibility to apoptosis decreases — memory B cell Human  
DAA1058 Body fat increases — whole body Human  
DAA751 Body temperature circadian rhythm flattens — whole body Human  
DAA1205 Body temperature decreases with age — whole body Human  
DAA653 Bone becomes more brittle, less flexible — bone Human  
DAA650 Bone density of total hip and femoral neck decreases — bone Human  
DAA648 Bone mass decreases — bone Human  
DAA649 Bone mineral density in cortical ulna decreases — ulna Human  
DAA651 Bone porosity increases — bone Human  
DAA645 Bone remodeling decreases — bone Human  
DAA647 Bone resorption increases for cortical bone — bone Human  
DAA728 Brain matter volume declines — brain Human  
DAA1217 Brain volume decrease — brain Human
DAA1993 Brain volume decreases in a regional-specific way — brain Human  
DAA665 Calcification makes cartilage more brittle — cartilage Human  
DAA663 Calcification of cartilage matrix — cartilage Human  
DAA801 Calcification of costal cartilage — thorax, cartilage Human  
DAA848 Calcium absorption in intestine decreases — intestine Human  
DAA765 Calcium binding capacity decreases in neurons — brain Human  
DAA678 Capacity of mesenchymal stem cells to differentiate into osteoblasts may be decreased — mesenchymal stem cell Human  
DAA808 Capacity of neuromusclar junctions to transmit impulses decreases — respiratory system Human  
DAA908 Carbohydrate homeostasis deficits following glucose challenge — endocrine system Human  
DAA713 Cardiac index decreased — heart Human  
DAA666 Cartilage asbestos transformation€ — cartilage Human  
DAA664 Cartilage calcification interferes with normal diffusion metabolism — cartilage Human  
DAA658 Cartilage color changes — cartilage Human  
DAA660 Cartilage joint surface cracks and frays — cartilage Human  
DAA667 Cartilage matrix softening and cavity formation — cartilage Human  
DAA661 Cartilage matrix synthesis to degradation ratio decreases — cartilage Human  
DAA671 Cartilage resiliency decreases — cartilage Human  
DAA659 Cell number decreases in cartilage — cartilage Human  
DAA695 Cell proliferation increases — arterial intima Human  
DAA704 Cellular hypertrophy in left ventricular wall — left ventricle Human  
DAA741 Cerebral blood flow and glucose utilization are reduced — brain Human  
DAA738 Cerebral spinal fluid amount increases — brain Human  
DAA995 Change in weave of dermis collagen fibers — dermis Human  
DAA2046 Changes in fat distribution — adipose tissue Human  
DAA1011 Changes in glycosaminoglycan/proteoglycan — epidermis, dermis Human
DAA996 Changes to dermis collagen fiber bundles — dermis Human  
DAA998 Changes to elastin fibers in lower dermis — dermis Human  
DAA972 Chemotaxis and adhesion activity unchanged in vitro — neutrophil Human  
DAA973 Chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased — neutrophil Human  
DAA974 Chemotaxis is reduced — neutrophil, dendritic cell Human  
DAA1053 Cholesterol level - High (Female) SeriesIncidence plasma Human
DAA1052 Cholesterol level - High (Male) SeriesIncidence plasma Human
DAA669 Chondroitin sulfate molecules are smaller — cartilage Human  
DAA670 Chondroitin sulfate molecules' water-binding capacity is decreased — cartilage Human  
DAA2600 Chromosome deletions, duplications, and gene conversion events accumulate with age — colon Human  
DAA968 Chronic inflammation increases — blood, immune system Human  
DAA1213 Circadian GH change — plasma Human  
DAA1212 Circadian plasma melatonin flattened — plasma Human  
DAA1214 Circadian prolactin flattened — plasma Human  
DAA1198 Circadian Rhythm — whole body Human  
DAA2052 Cold-induced heat production tends to decrease — whole body Human  
DAA2029 Color of lenses increases — lens Human  
DAA799 Compliance of parenchyma increases — lung Human  
DAA740 Cortical plasticity decreases — brain Human  
DAA916 Cortisol levels increased — plasma Human  
DAA1062 Creatinine clearance declines — kidney Human  
DAA1983 Critical decline in fine motor hand movements — nervous system Human  
DAA986 Cytotoxicity and interleukin-2 response of natural killer cells decreases — natural killer cell Human  
DAA1000 Decline in epidermis keratinocyte turnover — epidermis Human  
DAA924 Decline in ovarian estrogen production — ovary Human
DAA806 Decline in respiratory muscle fibers — respiratory system, muscle Human  
DAA1229 Declining T-lymphocyte production in the thymus — thymus Human  
DAA2050 Decreased ability to maintain body temperature when exposed to cold — whole body Human  
DAA1002 Decreased ability to modulate heat loss — integument system Human  
DAA1006 Decreased amounts of collagen IV and VII, and abnormal elastin in dermis — dermis Human  
DAA1004 Decreased/disorganized fibril network of dermis — dermis Human  
DAA991 Decreased function of epithelial barriers — lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis Human  
DAA796 Decrease in alveoli elasticity and recoil forces — alveolus Human  
DAA829 Decrease in amplitude of peristaltic pressure wave in upper esophogeal sphincter — oesophagus Human  
DAA1995 Decrease in collagen in the venous intima 42.0% DecreaseProtein level venous intima Human  
DAA992 Decrease in dermal papillae density — epidermis, dermis Human  
DAA921 Decrease in melatonin concentration and loss of circadian rhythm for secretion — plasma, pineal gland Human  
DAA832 Decrease in number of acinar cells — salivary gland Human  
DAA1988 Decrease in the 24-hour integrated concentration of GH — plasma Human  
DAA802 Decreases in intevertebral spaces — spine Human  
DAA852 Deficiencies in generating secondary peristaltic contractions — oropharynx, oesophagus Human  
DAA922 Deficits in homeostatic equilibrium controlled by endocrine system — endocrine system Human  
DAA739 Degeneration of dopamine neurons and receptors — brain Human  
DAA726 Demyelination — white matter Human  
DAA717 Dendrite regression, reduction in dendrite length — brain Human  
DAA825 Dental wear and tear — tooth Human  
DAA2588 Depletion of hair follicle melanocytes — hair follicle Human  
DAA764 Depolarization of mitochondria — brain Human  
DAA1009 Dermal collagen atrophies — dermis Human  
DAA910 DHEA levels decrease — plasma Human
DAA685 Diastolic blood pressure changes — cardiovascular system Human  
DAA1985 Diastolic dysfunction with aging — cardiovascular system Human  
DAA881 Dietary protein required to induce renal sclerotic lesions decreases — renal vasculature Human  
DAA983 Diminished superoxide production in response to Fc — neutrophil Human  
DAA830 Diminishing of glandular secretions — alimentary system Human  
DAA2021 Diminution in the resting cardiac output — heart Human  
DAA2027 DNA damage acummulates in hematopoietic stem and progenitor cells — hematopoietic stem cells Human  
DAA762 Down regulation of calcium clearance from nerve cells — brain Human  
DAA835 D-xylose absorption decreases — alimentary system Human  
DAA800 Dynamic compliance decreases — lung Human  
DAA850 Dysphagia incidence increases — oropharynx, oesophagus Human  
DAA749 Earlier circadian temperature phase — whole body Human  
DAA744 EEG alterations during auditory test — brain Human  
DAA690 Elastic and smooth muscle layers increase in size — arterial intima Human  
DAA803 Elastic fiber number in the lungs decreases — lung Human  
DAA691 Elastic fibers become fragmented, redistributed, and thinned — artery Human  
DAA997 Elastin fibers lost from upper layers of dermis — dermis Human  
DAA689 Endothelial cells more irregular in size and shape — arterial intima Human  
DAA858 Enteric neuron loss — alimentary system Human  
DAA993 Epidermis held less tightly to dermis — epidermis Human  
DAA1230 E-rosette-forming cells decrease — thymus Human  
DAA853 Esophageal acid contact time increased — oesophagus Human  
DAA2585 Exocrine pancreatic function unchanged — pancreas Human  
DAA963 Expansion into effector cells is reduced — naïve T cell Human  
DAA2028 Eye lenses become much stiffer — lens Human
DAA710 Facets of heart physiology altered during exercise — heart Human  
DAA952 Fewer CD4+ and CD8+ cells — T cell Human  
DAA1073 Fewer cells and higher apoptosis — bone marrow Human  
DAA662 Fibril types in cartilage matrix are altered — cartilage Human  
DAA791 Forced expiratory volume decreases — lung Human  
DAA792 Forced vital capacity decreases — lung Human  
DAA654 Fractures are cleaner — bone Human  
DAA2596 Frequency of mitochondrial DNA deletions increases with age — brain Human  
DAA2595 Frequency of somatic mitochondrial mutations increases with age — brain Human  
DAA985 Functional decline and decreases in macrophage numbers in bone marrow — macrophage Human  
DAA843 Gastric lipase and bile acid secretion decreases — stomach, small intestine Human  
DAA834 Gastric secretions diminish — alimentary system Human  
DAA907 Glands change in appearance — endocrine system Human  
DAA732 Glial cell number — cerebral cortex Human  
DAA724 Global neuron loss — cerebral cortex Human  
DAA887 Glomerular filtration rate declines — glomerulus Human  
DAA889 Glomeruli crowd together — glomerulus Human  
DAA888 Glomeruli number decreases — glomerulus Human  
DAA2593 Glycosylation of immunoglobulin G molecules changes with age — blood Human  
DAA729 Gray matter volume decreases — grey matter Human  
DAA674 Grip strength decreases — musculoskeletal system Human  
DAA2587 Hair greying — hair Human  
DAA711 Heart physiology measurements unchanged — heart Human  
DAA712 Heart physiology parameters altered — heart Human  
DAA1991 Hematopoietic cells accumulate random mutations — hematopoietic stem cells Human
DAA1215 Higher adrenocroticotropic hormone levels — plasma Human  
DAA926 Hot flushes — whole body Human  
DAA1207 IL8 level increase — plasma Human  
DAA950 Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals — immune system Human  
DAA965 Incidence of anergia increases — immune system Human  
DAA961 Increased apoptosis associated with Fas and Fas-ligand expression — T cell Human  
DAA787 Increased bilateral anterior frontal activity in memory interference tests — brain Human  
DAA786 Increased rhinal cortex activity and functional connectivity in tests for verbal familiarity — brain Human  
DAA783 Increased sustained activity in tests of working memory — brain Human  
DAA784 Increased transient activity in non-spatial auditory working memory test — brain Human  
DAA833 Increase in adverse effects on salivary gland by anticholinergics — salivary gland Human  
DAA828 Increase in amplitude and duration of peristaltic pressure wave in hypopharyngeal sphincter — hypopharynx Human  
DAA953 Increase in cells that are both CD8+ and CD28-null — T regulatory cell Human  
DAA1994 Increase in collagen in the arterial intima 100.0% IncreaseProtein level arterial intima Human  
DAA925 Increase in follicle stimulating hormone (FSH) and luteinizing hormone (LH) preceding menopause — plasma Human  
DAA838 Increase in IgA — intestine Human  
DAA847 Increase in incidence of diverticulosis — large intestine Human  
DAA987 Increase in total number of cells — natural killer cell Human  
DAA975 Infiltration at injury site is reduced — neutrophil Human  
DAA1200 Inhibin levels decline  DecreaseHormone Level plasma Human  
DAA962 Interleukin-2 production in response to influenza vaccine declines — T cell Human  
DAA955 Interleukin-7 production declines — stromal cell Human  
DAA894 Interstitial fibrosis in medulla — kidney Human  
DAA694 Intima undergoes diffuse thickening — arterial intima Human  
DAA672 Joint cushioning reduced — joint Human
DAA2039 K-ATP channels upregulated in human myometrium — myometrium Human  
DAA880 Kidney mass gradually lost — kidney Human  
DAA1984 Layer-specific dendritic regression of pyramidal cells — prefrontal cortex Human  
DAA1057 Lean body mass decreases — whole body Human  
DAA944 Less antibodies generated — B cell Human  
DAA725 Leukoaraiosis — white matter Human  
DAA841 Lipid absorption and solubilization decreases — small intestine Human  
DAA715 Lipid biosynthesis decreases — central nervous system Human  
DAA705 Lipofuscin increases — heart Human  
DAA735 Localized increases and decreases in synaptic transmission — brain Human  
DAA823 Loss of elastic recoil — lung Human  
DAA2590 Loss of liver regeneration with age — liver Human  
DAA2045 Loss of muscle torque — skeletal muscle Human  
DAA809 Loss of peripheral motor neurons — respiratory system, muscle Human  
DAA1005 Loss of smooth padding provided by hypodermal fat cells — skin Human  
DAA2589 Male baldness — hair Human  
DAA2584 Male fertility — male reproductive system Human  
DAA813 Maximal inspiratory pressure decreases — lung Human  
DAA819 Maximum volume of air in lungs decreases — lung Human  
DAA706 Maximum workload in response to exercise stress decreases — heart Human  
DAA909 Mean blood glucose level increases — plasma Human  
DAA731 Mean diffusivity increases and water diffusion anisotropy decreases — corpus callosum, white matter Human  
DAA780 Medial temporal activation during encoding and retrieval of memory is reduced — brain Human  
DAA923 Menopause and female fertility loss — female reproductive system, endocrine system Human  
DAA681 Metabolic syndrome components associated with measures of arterial stiffness — artery Human
DAA2014 Microsatellite instability in hematopoietic stem cells and progenitor cells — hematopoietic stem cells Human  
DAA999 Microvascular alterations in arterioles, capillaries, and venules in dermis/hypodermis — dermis, subcutaneous Human  
DAA855 Migrating motor complex is prolonged — small intestine Human  
DAA652 Mineralization of bone tissue increases — bone Human  
DAA2597 Mitochondrial DNA content in non-centenerians decreases with age — blood Human  
DAA1219 Morning concentration of oestrone (E1) declines — plasma Human  
DAA1221 Morning concentration of sex-hormone binding globulin declines — plasma Human  
DAA1218 Morning concentrations of oestradiol decline — plasma Human  
DAA1180 Morning concentrations of testosterone decline 80.0% DecreaseHormone Level plasma Human
DAA1181 Morning IGF1 decline 51.0% DecreaseHormone Level plasma Human
DAA2058 Mosaic abnormalities increase — blood, oral cavity Human  
DAA742 Motor function impairment evident in altered gait and balance — nervous system Human  
DAA831 Mouth becomes drier — salivary gland Human  
DAA642 Muscle atrophy (sarcopenia) — skeletal muscle Human  
DAA2592 Muscle characteristics change with aging — muscle Human  
DAA643 Muscle fiber energy metabolism declines — skeletal muscle Human  
DAA1992 Muscle mass and strength loss — skeletal muscle Human  
DAA2026 Mutations in mitochondrial DNA accumulate — heart, kidney, skeletal muscle, cerebral cortex, cerebellum Human  
DAA857 Myenteric plexus neuron number decreases — oesophagus, stomach, intestine Human  
DAA939 Naive cell number increases and memory cells decrease — B cell Human  
DAA891 Nephrons appear to fail as units — nephron Human  
DAA721 Neurofibrillary tangles and Lewy bodies in neurons — brain Human  
DAA714 Neuronal soma shrinks in size — brain Human  
DAA733 Neurotransmitter and neuro receptor concentrations are altered — brain Human  
DAA933 No changes in erythroid and myeloid progenitor cells evident — myeloid progenitor cell Human
DAA860 Nonadrenergic innervation of myenteric plexus decreases — jejunum Human  
DAA2013 Number and differentiation potential of adipose tissue-derived stem cells declines with age — mesenchymal stem cell Human  
DAA816 Number of alveoli decreases — alveolus Human  
DAA934 Number of mature B cells leaving the bone marrow declines — bone marrow, B cell Human  
DAA1990 Number of mutations in offsprings increases — male reproductive system Human  
DAA954 Number of T cell progenitors declines — T cell progenitor Human  
DAA1063 Orthostatic hypotension incidence increases — cardiovascular system Human  
DAA646 Osteoporosis: progressive loss of bone strength — bone Human  
DAA701 Oxidative increase in cystine/cysteine ratio — plasma Human  
DAA757 Parkinsonian signs — nervous system Human  
DAA793 Peak flow decreases — lung Human  
DAA851 Peristaltic amplitude is diminished — oropharynx, oesophagus Human  
DAA737 Permeability increases with age — blood brain barrier Human  
DAA980 Phagocytosis activity decreased in response to opsonized targets — neutrophil Human  
DAA981 Phagocytosis activity unchanged in response to unopsonized targets — neutrophil Human  
DAA899 Phosphate reabsorption decreased — renal tubule Human  
DAA917 Plasma and urinary catecholamine elevation after stimuli — plasma Human  
DAA844 Postprandial serum bile acids decrease — alimentary system Human  
DAA779 Prefrontal cortex activation during learning is reduced — brain Human  
DAA935 Pro-B cell generation and differentiation declines — bone marrow, B cell Human  
DAA1076 Progressive liquefaction — vitreous humor Human  
DAA2022 Prolactin decreases in females — plasma Human  
DAA920 Prolactin increases in males — plasma Human  
DAA956 Proliferation is reduced — lymphocytes Human  
DAA676 Proliferation rate of mesenchymal stem cells is reduced — mesenchymal stem cell Human
 
DAA763 Prolongation of calcium signals in nerve cells — brain Human  
DAA677 Proportion of apoptotic cells may be increased — mesenchymal stem cell Human  
DAA668 Proteoglycan alterations in cartilage — cartilage Human  
DAA702 Ratio of oxidized to unoxidized plasma albumin increases — plasma Human  
DAA1980 Reaction time for a visually paced simple motor task increases with age — brain Human  
DAA960 Receptor expression alterations — grey matter Human  
DAA785 Reduced hippocampal activity and functional connectivity in tests for verbal familiarity — brain Human  
DAA2040 Reduced type II muscle fiber — skeletal muscle Human  
DAA2020 Reduction in renal function — kidney Human  
DAA840 Reduction in small intestine absorption rate — small intestine Human  
DAA2049 Reduction in total body protein — whole body Human  
DAA2015 Regulation of the acid-base equilibrium of the blood unchanged — blood Human  
DAA885 Renal blood flow declines — renal vasculature Human  
DAA932 Renewal capacity declines — hematopoietic stem cells Human  
DAA2598 Renewal rate of cardiomyocytes decreases with age — heart Human  
DAA811 Respiratory drive decreases — respiratory system Human  
DAA810 Respiratory muscle strength declines — respiratory system, muscle Human  
DAA812 Responses to hypoxemia and hypercapnia are decreased — respiratory system Human  
DAA897 Response to antidiuretic hormone decreased — renal tubule Human  
DAA708 Response to beta-adrenergic stimulation decreased — heart Human  
DAA859 Responsiveness of cholinergic receptors is decreased — ileum Human  
DAA861 Resting and squeeze pressures in anal canal decrease — anus Human  
DAA2594 Resting metabolic rate decreases with ageing — whole body Human  
DAA977 ROS production in response to stimuli unchanged — neutrophil Human  
DAA1981 Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra — substantia nigra Human
DAA743 Sensitivity of HPA axis is impaired — pituitary gland, adrenal gland, hypothalamus Human  
DAA1199 Serum klotho  IncreaseHormone Level plasma Human  
DAA928 Sex hormone binding globulin levels increase — plasma Human  
DAA2001 SIRT1 activity negatively correlated with age in males — skin Human  
DAA994 Skin thinning — epidermis, dermis Human  
DAA827 Slowing down of peristaltic motion in alimentary canal — alimentary system Human  
DAA898 Sodium conservation decreased — renal tubule Human  
DAA919 Somatostatin basal levels increase — plasma Human  
DAA931 Sperm motility and concentration — male reproductive system Human  
DAA984 Spontaneous production of superoxide decreased — neutrophil Human  
DAA2053 Sweating capacity decreases — sweat gland Human  
DAA718 Synaptic density slightly decreases at advanced ages — frontal lobe Human  
DAA656 Synovial fluid alterations — synovium Human  
DAA682 Systolic blood pressure increases — cardiovascular system Human  
DAA964 T-cell diversity declines — T cell Human  
DAA2599 Telomere shortening — adipose tissue, skeletal muscle, skin, leukocyte Human  
DAA644 Tendons' ability to elongate decreases — tendon Human  
DAA2032 The ratio of free to bound water increases — lens Human  
DAA862 Threshold sensational level for rectal filling increase — rectum, anus Human  
DAA946 Thymic hormone levels decrease — plasma Human  
DAA945 Thymus involution — thymus Human  
DAA2048 Total body potassium declines — whole body Human  
DAA2024 Total body water decreases — whole body Human  
DAA2030 Transmission of visible light through eye lenses decreases — lens Human  
DAA904 Transport maximum for glucose declines — renal tubule Human
DAA699 Triglyceride levels increase — plasma Human  
DAA900 Urine concentrating capacity decreases — renal tubule Human  
DAA966 Vaccination antibody response is impaired — immune system Human  
DAA1061 Variability in clearance of hepatically metabolized drugs — liver Human  
DAA2043 Variations in body weight — whole body Human  
DAA2044 Variations in fat mass — adipose tissue Human  
DAA896 Vasodilation induced by acetylcholine or sodium reduced — renal vasculature Human  
DAA794 Ventilatory rate at maximum exertion decreases — lung Human  
DAA788 Viscoelastic modulus of brain tissue decreases — brain Human  
DAA2583 Vision loss — visual apparatus Human  
DAA936 Volume of hematopoietic bone marrow decreases — bone marrow Human  
DAA948 Volume of perivascular space around thymus increases — thymus Human  
DAA703 Wall increases in thickness — left ventricle Human  
DAA846 Weakening of intestinal wall — large intestine Human  
DAA826 Weaker digestive tract muscle contractions — alimentary system, smooth muscle Human  
DAA730 White matter volume decreases — white matter Human  
DAA884 Widespread degeneration of glomerular blood vessels — renal vasculature Human  
DAA1003 Wrinkles — skin Human