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| Gene Symbol (Name) | Description | Change gender | Age change starts | Age change ends | Tissues | Percentage change | P value | References |
| CXorf57 (chromosome X open reading frame 57) | Male and Female | 20 | 75 | Skeletal Muscle | 35.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CXorf57 (chromosome X open reading frame 57) | Using a linear mixed model, differential expression with age was identified in CXorf57 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CXXC1 (CXXC finger protein 1) | Using a linear mixed model, differential expression with age was identified in CXXC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB561A3 (cytochrome b561 family, member A3) | Using a linear mixed model, differential expression with age was identified in CYB561A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB561D2 (cytochrome b561 family, member D2) | Using a linear mixed model, differential expression with age was identified in CYB561D2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB5A (cytochrome b5 type A (microsomal)) | Using a linear mixed model, differential expression with age was identified in CYB5A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYC1 (cytochrome c-1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYC1 (cytochrome c-1) | Using a linear mixed model, differential expression with age was identified in CYC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYCS (cytochrome c, somatic) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYFIP2 (cytoplasmic FMR1 interacting protein 2) | mRNA editing of CYFIP2, a p53 inducible protein thought to be involved in synaptic maintenance, decreases with age. No changes with age in mRNA editing were observed for GABRA3. | Male and Female | -1 | -1 | Frontal Lobe | 0.0 | 2900: Nicholas et al. (2010) "Age-related gene-specific changes of A-to-I mRNA editing in the human brain." Mech. Ageing Dev. 131(6):445-447 (20538013) | |
| CYFIP2 (cytoplasmic FMR1 interacting protein 2) | Male and Female | 27 | 92 | Kidney | -11.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| CYGB (cytoglobin) | Using a linear mixed model, differential expression with age was identified in CYGB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) | Using a linear mixed model, differential expression with age was identified in CYP1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP1B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP27A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cyp2c39 (cytochrome P450, family 2, subfamily c, polypeptide 39) | Male and Female | 6 | 22 | Liver | -8.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CYP2J2 (cytochrome P450, family 2, subfamily J, polypeptide 2) | Male and Female | 26 | 106 | Brain | 9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) | Using a linear mixed model, differential expression with age was identified in CYP3A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4F12 (cytochrome P450, family 4, subfamily F, polypeptide 12) | Using a linear mixed model, differential expression with age was identified in CYP4F12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) | Using a linear mixed model, differential expression with age was identified in CYP4F22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Male and Female | 20 | 75 | Skeletal Muscle | 12.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP4X1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP4X1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1) | Male and Female | 3 | 23 | Hematological System | 35.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Cysltr2 (cysteinyl leukotriene receptor 2) | Male and Female | 3 | 23 | Hematological System | 17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CYTL1 (cytokine-like 1) | Using a linear mixed model, differential expression with age was identified in CYTL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| D030056L22Rik (RIKEN cDNA D030056L22 gene) | Male and Female | 5 | 25 | Skeletal Muscle | -7.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| D0H4S114 (DNA segment, human D4S114) | Male and Female | 2 | 26 | Lung | -12.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| D0H4S114 (DNA segment, human D4S114) | Male and Female | 2 | 15 | Hippocampus | -5.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| D10627 (cDNA sequence D10627) | Male and Female | 5 | 25 | Skeletal Muscle | -8.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| D1Ertd705e (DNA segment, Chr 1, ERATO Doi 705, expressed) | Male and Female | |||||||
| Reference: Source: AmiGo 2 | ||||||||