|
Name |
Symbol |
Entrez ID |
Max average lifespan change |
|
Adrenergic receptor, alpha 1a |
Adra1a |
11549 |
10% Upregulatedd |
|
Apolipoprotein E |
Apoe |
11816 |
Downregulated |
|
Rho GTPase activating protein 1 |
Arhgap1 |
228359 |
Downregulated |
|
aryl hydrocarbon receptor nuclear translocator-like |
Arntl |
11865 |
Downregulated |
|
Autophagy related 5 |
Atg5 |
11793 |
17% Upregulatedd |
|
Ataxia telangiectasia mutated homolog (human) |
Atm |
11920 |
Downregulated |
|
Ataxia telangiectasia and Rad3 related |
Atr |
245000 |
Downregulated |
|
Bcl2-associated X protein |
Bax |
12028 |
Upregulatedd |
|
Breast cancer 1 |
Brca1 |
12189 |
Downregulated |
|
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) |
Bub1b |
12236 |
Upregulated and Downregulated |
|
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) |
Bub3 |
12237 |
12% Downregulated |
|
Caspase 2 |
Casp2 |
12366 |
Downregulated |
|
Catalase |
Cat |
12359 |
21% Upregulatedd |
|
Caveolin, caveolae protein 1 |
Cav1 |
12389 |
50% Downregulated |
|
CDC14 cell division cycle 14B |
Cdc14b |
218294 |
|
|
cyclin-dependent kinase 7 |
Cdk7 |
12572 |
Downregulated |
|
CCAAT/enhancer binding protein (C/EBP), alpha |
Cebpa |
12606 |
Upregulatedd |
|
CCAAT/enhancer binding protein (C/EBP), beta |
Cebpb |
12608 |
Upregulatedd |
|
CHK2 checkpoint homolog (S. pombe) |
Chek2 |
50883 |
Downregulated |
|
CDGSH iron sulfur domain 2 |
Cisd2 |
67006 |
Upregulated and Downregulated |
|
Circadian locomotor output cycles kaput |
Clock |
12753 |
15% Downregulated |
|
collagen, type I, alpha 1 |
Col1a1 |
12842 |
Downregulated |
|
Dystrophin, muscular dystrophy |
Dmd |
13405 |
18% Downregulated |
|
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 |
Efemp1 |
216616 |
20% Downregulated |
|
excision repair cross-complementing rodent repair deficiency, complementation group 1 |
Ercc1 |
13870 |
83% Downregulated |
|
Excision repair cross-complementing rodent repair deficiency, complementation group 2 |
Ercc2 |
13871 |
Downregulated |
|
Excision repair cross-complementing rodent repair deficiency, complementation group 4 |
Ercc4 |
50505 |
Downregulated |
|
fibroblast growth factor 21 |
Fgf21 |
56636 |
36% Upregulatedd |
|
Fibroblast growth factor 23 |
Fgf23 |
64654 |
Downregulated |
|
Fibronectin 1 |
Fn1 |
14268 |
Downregulated |
|
Forkhead box M1 |
Foxm1 |
14235 |
Downregulated |
|
frataxin |
Fxn |
14297 |
Downregulated |
|
glucose-6-phosphate dehydrogenase |
G6PD |
2539 |
14% Upregulatedd |
|
growth differentiation factor 15 |
Gdf15 |
23886 |
43% Upregulatedd |
|
granulin |
Grn |
14824 |
Downregulated |
|
glycogen synthase kinase 3 alpha |
Gsk3a |
606496 |
Downregulated |
|
Proliferation associated SNF-2-like gene |
Hells |
15201 |
Downregulated |
|
heterogeneous nuclear ribonucleoprotein D |
Hnrnpd |
11991 |
Downregulated |
|
5-hydroxytryptamine (serotonin) receptor 1B |
Htr1b |
15551 |
Downregulated |
|
HtrA serine peptidase 2 |
Htra2 |
64704 |
Downregulated |
|
Insulin-like growth factor 1 |
Igf1 |
16000 |
Upregulated and Downregulated |
|
Jun proto-oncogene related gene d |
Jund |
16478 |
17% Downregulated |
|
Klotho |
Kl |
16591 |
Upregulated and Downregulated |
|
lamin A |
Lmna |
16905 |
Upregulated and Downregulated |
|
minichromosome maintenance deficient 2 mitotin (S. cerevisiae) |
Mcm2 |
17216 |
Downregulated |
|
mannoside acetylglucosaminyltransferase 5 |
Mgat5 |
107895 |
Downregulated |
|
microRNA 17 |
Mir17 |
723905 |
16% Upregulatedd |
|
microRNA 29a |
Mir29a |
387222 |
|
|
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
Msh2 |
17685 |
Downregulated |
|
Methionine sulfoxide reductase A |
Msra |
110265 |
Downregulated |
|
metallothionein 1 |
Mt1 |
17748 |
14% Upregulatedd |
|
nuclear receptor co-repressor 2 |
Ncor2 |
20602 |
50% Downregulated |
|
nei endonuclease VIII-like 1 (E. coli) |
Neil1 |
72774 |
Downregulated |
|
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
Nfkb1 |
18033 |
33% Downregulated |
|
nitric oxide synthase 3, endothelial cell |
Nos3 |
18127 |
Downregulated |
|
nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
NUDT1 |
4521 |
16% Upregulatedd |
|
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) |
Parp1 |
11545 |
25% Downregulated |
|
PRKC, apoptosis, WT1, regulator |
Pawr |
114774 |
Upregulated and Downregulated |
|
phosphoenolpyruvate carboxykinase 1, cytosolic |
Pck1 |
18534 |
Upregulatedd |
|
Plasminogen activator, urokinase |
Plau |
18792 |
20% Upregulatedd |
|
Polymerase (DNA directed), gamma |
Polg |
18975 |
Downregulated |
|
Peroxisome proliferator activated receptor gamma |
Pparg |
19016 |
Upregulated and Downregulated |
|
protein phosphatase 1D magnesium-dependent, delta isoform |
Ppm1d |
53892 |
Downregulated |
|
Peroxiredoxin 1 |
Prdx1 |
18477 |
Downregulated |
|
Phosphatase and tensin homolog |
Pten |
19211 |
Upregulated and Downregulated |
|
RAE1 RNA export 1 homolog (S. pombe) |
Rae1 |
66679 |
Downregulated |
|
RNA binding motif protein 38 |
Rbm38 |
56190 |
22% Downregulated |
|
RPTOR independent companion of MTOR, complex 2 |
Rictor |
78757 |
40% Downregulated |
|
sialic acid binding Ig-like lectin E |
Siglece |
83382 |
17% Downregulated |
|
Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) |
Sirt1 |
93759 |
Upregulated and Downregulated |
|
sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) |
Sirt6 |
50721 |
Upregulated and Downregulated |
|
Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) |
Sirt7 |
209011 |
59% Downregulated |
|
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 |
Slc25a4 |
11739 |
Downregulated |
|
Suppressor of cytokine signaling 2 |
Socs2 |
216233 |
35% Downregulated |
|
Superoxide dismutase 2, mitochondrial |
Sod2 |
20656 |
43% Downregulated |
|
superoxide dismutase 3 |
SOD3 |
6649 |
Downregulated |
|
sequestosome 1 |
Sqstm1 |
18412 |
34% Downregulated |
|
STIP1 homology and U-Box containing protein 1 |
Stub1 |
56424 |
Downregulated |
|
Telomerase reverse transcriptase |
Tert |
21752 |
Upregulatedd |
|
Topoisomerase (DNA) III beta |
Top3b |
21976 |
Downregulated |
|
Topoisomerase I binding, arginine/serine-rich |
Topors |
106021 |
42% Downregulated |
|
Tripeptidyl peptidase II |
Tpp2 |
22019 |
Downregulated |
|
Transformation related protein 53 |
Trp53 |
22059 |
23% Downregulated |
|
Transformation related protein 63 |
Trp63 |
22061 |
70% Downregulated |
|
transformation related protein 73 |
Trp73 |
22062 |
31% Downregulated |
|
Thioredoxin 1 |
Txn1 |
22166 |
35% Upregulatedd |
|
uncoupling protein 2 (mitochondrial, proton carrier) |
Ucp2 |
22228 |
20% Upregulatedd |
|
Xeroderma pigmentosum, complementation group A |
Xpa |
22590 |
Downregulated |
|
X-ray repair complementing defective repair in Chinese hamster cells 5 |
Xrcc5 |
22596 |
40% Downregulated |
|
X-ray repair complementing defective repair in Chinese hamster cells 6 |
Xrcc6 |
14375 |
Downregulated |
|
zinc metallopeptidase, STE24 homolog (S. cerevisiae) |
Zmpste24 |
230709 |
Downregulated |
| Reference: HAGR |