Life extension by drugs
Compound/Formulation
 
Species Avg/Med Lifespan Change (%) Max Lifespan Change (%)
 
Strain
 
Dosage
 
Significant? Reference
Lithocholic acid Saccharomyces cerevisiae 105.5 93 BY4742 50 µM Y 30405886
Thioflavin T Caenorhabditis elegans 60 78 N2 50-100 µM Y 21451522
Bacitracin Caenorhabditis elegans 58.5 74 N2 0.01 Y 22114686
Acetaminophen Caenorhabditis elegans 48.6 66 N2 0.10% Y 22114686
Minocycline Drosophila melanogaster 50 66 Oregon R 0.87 mM Y 23185716
N-acetyl-L-cysteine Caenorhabditis elegans 24.49 64 N2 9 mM Y 27683245
Resveratrol Nothobranchius furzeri 56 59 Gonarezhou 600 µg/g food Y 16461283
Sorbitol Caenorhabditis elegans 39.35 57.89 N2 500 mM Y 26854551
Trimethadione Caenorhabditis elegans 47 57 N2 4 mg/ml Y 15653505
2-deoxy-D-glucose Caenorhabditis elegans 12.93 56.49 N2 5 mM Y 17908557
Dimethyl formamide Caenorhabditis elegans 33 54 N2 0.0075 Y 23313473
Baicalein Caenorhabditis elegans 36.7 52 N2 0.001 Y 22114686
Ciclopirox olamine Caenorhabditis elegans 41 52 N2 0.0001 Y 22114686
Ascorbic acid Caenorhabditis elegans   50 N2 25 µL Liposomes + 240 µg ascorbic acid Y 19580823
Glutathione Caenorhabditis elegans   50 N2 25 µL Liposomes + 360 µg glutathione Y 19580823
Trimethadione Caenorhabditis elegans   50 N2 25 µL Liposomes + 0.6mg trimethadione Y 19580823
Nicotinamide Saccharomyces cerevisiae 35.96 50 W303-1A 5 mM Y 27320176
3,3-diethyl-2-pyrrolidinone Caenorhabditis elegans 31 49 N2 2 mg/ml Y 15653505
3,3-diethyl-2-pyrrolidinone Caenorhabditis elegans 31 49 N2 2 mg/ml Y 15653505
Curcumin Drosophila melanogaster 49 49 Ra 100 mM Y 23063786
Paraquat Caenorhabditis elegans 58 48 N2 0.1 mM Y 21151885
Aspirin Mus musculus 8 47.2 UM-HET3 21 mg/kg food Y 18631321
N-acetyl-L-cysteine Caenorhabditis elegans 30.5 47.1 N2 CGCb strain 5 mM Y 26039957
Mianserin Caenorhabditis elegans 28.3 46 N2 50 µM Y 26255886
Withanolide A Caenorhabditis elegans 29.65 45.33 N2 5 µM Y 26956478
N-acetyl-L-cysteine Mus musculus 24 45 UM-HET3 10 g/L of water Y 20819793
Sodium Chloride Caenorhabditis elegans 40.53 44.44 N2 250 mM Y 26854551
Sodium Chloride Caenorhabditis elegans 40.53 44.44 N2 350 mM Y 26854551
Protease treated royal jelly Caenorhabditis elegans 18 44 N2 10 µg/ml Y 21858156
Rhodiola rosea extract Drosophila melanogaster   42.9   30 mg/mL every other day ND 9825229
N-acetyl-L-cysteine Caenorhabditis elegans   42.9 N2 25 µL Liposomes + 100 µg NAC Y 19580823
Valproic acid Caenorhabditis elegans 35 42 N2 6 mM Y 18248662
4-phenylbutyrate Drosophila melanogaster 40 41 Canton S 5 mM ND 11792861
Protocatechuic acid Caenorhabditis elegans 38.9 40 N2 200 µM Y 23780797
Dimethylaminoethyl p-chlorophenoxyacetate Rattus norvegicus 27.3 39.7 Swiss 0.3g/L Y 4147092
Curcumin Drosophila melanogaster 46.8 38 Ra 100 mM Y 23063786
Curcumin Drosophila melanogaster 46.8 38 Ra 100 mM Y 26136617
Trichostatin A Drosophila melanogaster 27.3 37.9 Canton S 10 µM Y 15346199
Trichostatin A Drosophila melanogaster 23.3 37 Canton S 10 µM Y 15346199
Ethosuximide Caenorhabditis elegans 35 37 N2 4 mg/ml Y 15653505
Ethosuximide Caenorhabditis elegans 35 37 N2 4 mg/ml Y 15653505
Resveratrol Anastrepha ludens 8 36.3   100 µM N 19264118
Stachys lavandulifolia ethanol extract Drosophila melanogaster 55.7 36 Oregon R 20 µl/100 ml media Y 20738162
Rapamycin Caenorhabditis elegans 26 34.84 N2 100 µM Y 24332851
East Indian sandalwood oil Caenorhabditis elegans 26.36 34.78 N2 24 µ/mL Y 30319772
Sodium hypophosphite Zaprionus paravittiger 28.5 34.3   1 mM Y 3721207
Melatonin Drosophila melanogaster 14 33 Oregon R 100 µg/ml Y 11909680
Trimethadione Caenorhabditis elegans 39 33 N2 4 mg/ml Y 15653505
Resveratrol Nothobranchius guentheri 23 32 TZ 97-2 100 µL Y 22960591
Potassium Chloride Caenorhabditis elegans 23.23 31.58 N2 250 mM Y 26854551
Glycerol Caenorhabditis elegans 33.55 31.58 N2 500 mM Y 26854551
L-deprenyl Mus musculus 3.9 31.2 B6CBAF1 0.25 mg/kg 3x/week N 8914495
Rhodiola rosea extract Drosophila melanogaster 24 31   25 mg/mL Y 19634056
Paraquat Caenorhabditis elegans 23.73 30.77 N2 100 µM Y 27683245
East Indian sandalwood oil Caenorhabditis elegans 31.32 30.43 N2 24 µ/mL Y 30319772
Buthus martensii Karsch Polypeptide Toxin Caenorhabditis elegans 22.5 29.27 N2 Polypeptide DNA sequence inserted into the pGEX-4T-1 plasmid and transformed into pGEX-4T-1 Y 28088444
Resveratrol Caenorhabditis elegans 50.8 29.2 N2 50 µM Y 17460219
Trimethadione Caenorhabditis elegans 24 29 N2 4 mg/ml Y 15653505
Quercetin Caenorhabditis elegans 18 29 N2 200 µM Y 19043800
Rhodiola rosea extract Drosophila melanogaster   28.6   30 mg/mL every other day ND 9825229
Myxothiazol Caenorhabditis elegans 32.3 28.6 N2 10 µM Y 18221415
guarana ethanolic extract Caenorhabditis elegans 36.36 28.57 N2 500 µg/mL Y 29972429
guarana ethanolic extract Caenorhabditis elegans 36.36 28.57 N2 1000 µg/mL Y 29972429
Echinacea purpurea root Mus musculus   28 BALB/cByJ 2 mg/day ND 16041619
4-dafachronic acid Caenorhabditis elegans 16.6 28 N2 250 nM Y 17360327
Isoprenol Caenorhabditis elegans 25.26 28 N2 0.5 mM Y 30624146
Sodium hypophosphite Zaprionus paravittiger 28.1 27   1 mM Y 3721207
Butylated hydroxyanisole Zaprionus paravittiger 15.1 27   10 mM Y 9207858
Resveratrol Anastrepha ludens -2.3 26.5   100 µM N 19264118
Phenformin Mus musculus 21 26 C3H/Sn 2 mg, 5 times a week Y 14618027
Quercetin Caenorhabditis elegans 11 25 N2 100 µM Y 19043800
Naphthazarin Caenorhabditis elegans 22 25 N2 500 µM Y 21765926
Curcumin Drosophila melanogaster -8.2 25 Ra 100 mM Y 23063786
Curcumin Drosophila melanogaster 16.3 25 Ra 100 mM Y 23063786
Minocycline Drosophila melanogaster 50 25 Oregon R 0.87 mM Y 23185716
Protocatechuic acid Caenorhabditis elegans 23 25 N2 100 µM Y 23780797
Whole apple extract Caenorhabditis elegans 39 25 N2 10 mg/ml Y 23878618
β-Santalol Caenorhabditis elegans 12.56 25 N2 16 µM Y 30319772
β-Santalol Caenorhabditis elegans 25.38 25 N2 16 µM Y 30319772
Withanolide A Caenorhabditis elegans 15.79 24.58 N2 25 µM Y 26956478
N-acetyl-L-cysteine Drosophila melanogaster 26.8 24.5 Oregon R 10 mg/ml Y 9447249
Ethosuximide Caenorhabditis elegans 13 24 N2 2 mg/ml Y 15653505
Oxoline Caenorhabditis elegans 12 24 N2 1 mM Y 21765926
Oxoline Caenorhabditis elegans 10 24 N2 1 mM Y 21765926
Baicalein Caenorhabditis elegans 45 24 N2 100 µM ND 23339711
Fucoxanthin Caenorhabditis elegans 14 24 N2 5 µM Y 26292053
Blueberry extract Caenorhabditis elegans 44.42 24 N2 200 mg/mL Y 30238944
N-acetyl-L-cysteine Caenorhabditis elegans 27.1 23.5 N2 CGCb strain 2 mM Y 26039957
Trimethadione Caenorhabditis elegans 41 23 N2 4 mg/ml Y 15653505
Resveratrol Nothobranchius guentheri 13 23 TZ 97-2 100 µL Y 22960591
Sodium hypophosphite Zaprionus paravittiger 24.9 22.9   100 µM Y 3721207
Isoprenol Caenorhabditis elegans 19.23 22.6 N2 1 mM Y 30624146
Resveratrol Anastrepha ludens 15.6 22.5   100 µM Y 19264118
LY-294002 Drosophila melanogaster 14 22.5 Canton S 5 µM Y 20017609
Ethosuximide Caenorhabditis elegans 17 22 N2 4 mg/ml Y 15653505
Stachys lavandulifolia ethanol extract Drosophila melanogaster 31.3 22 Oregon R 12 µl/100 ml media Y 20738162
Sodium hypophosphite Zaprionus paravittiger 23.6 21.9   5 mM Y 3721207
East Indian sandalwood oil Caenorhabditis elegans 17.1 21.73 N2 12 µ/mL Y 30319772
Astaxanthin Caenorhabditis elegans 28.6 21.7 N2 1 mM Y 22013497
FCCP Caenorhabditis elegans 17.3 21.6 N2 50 µM Y 20346071
FCCP Caenorhabditis elegans 27.8 21.4 N2 50 µM Y 18221415
guarana ethanolic extract Caenorhabditis elegans 18.18 21.4 N2 100 µg/mL Y 29972429
Stachys lavandulifolia ethanol extract Drosophila melanogaster 26.8 21.3 Oregon R 12 µl/100 ml media Y 20738162
Sodium hypophosphite Zaprionus paravittiger 18 21   100 µM Y 3721207
Melatonin Paramecium tetraurelia 22.8 20.9   10 mg/L Y 9406982
Curcumin Drosophila melanogaster 25 20.2 Ra 100 mM Y 23063786
Acanthopanax sessiliflorus stem extract Caenorhabditis elegans 18 20 N2 500 mg/L Y 25324932
Dehydroabietic acid Caenorhabditis elegans 12.8 20 N2 10 µM Y 25976661
N-acetyl-L-cysteine Caenorhabditis elegans 9.07 20 N2 3 mM Y 27683245
Blueberry extract Caenorhabditis elegans 36.52 20 N2 100 mg/mL Y 30238944
Nicotinamide Saccharomyces cerevisiae 20.2 19.83 W303-1A 1 mM Y 27320176
Sodium hypophosphite Zaprionus paravittiger 25.4 19.7   5 mM Y 3721207
Kinetin Zaprionus paravittiger 80 19.7   25 ppm Y 7488181
N-Acetyl Cysteine Drosophila kikkawai 8 19.4   10 nM Y 30243020
Ribes fasciculatum eylacetate fraction Caenorhabditis elegans 16.3 19.05 N2 500 µg/mL Y 27478096
N-acetyl-L-cysteine Caenorhabditis elegans 14.6 19 N2 CGCb strain 5 mM N 26039957
S-allylmercapto-N-acetylcysteine Caenorhabditis elegans 15.5 18.75 CF512 2 mM Y 29579097
S-allylmercapto-N-acetylcysteine Caenorhabditis elegans 14.24 18.75 CF512 5 mM Y 29579097
Resveratrol Caenorhabditis elegans 6.24 18.75 N2 50 µM Y 27683245
Dimethyl sulfoxide Caenorhabditis elegans 29 18.6 N2 0.005 Y 20828537
Dehydroabietic acid Caenorhabditis elegans 11.8 18.1 N2 10 µM Y 25976661
Oxoline Caenorhabditis elegans 13 18 N2 1 mM Y 21765926
Tocotrienol Caenorhabditis elegans 21 18 N2 86 µg Y 22484623
Lithium Chloride Drosophila melanogaster 18 18 Dahomey 25 mM Y 27068460
Captopril Caenorhabditis elegans 23 18 N2 3.18 mM Y 26918946
Melatonin Paramecium tetraurelia   17.9   10 mg/L N 9406982
Butylated hydroxyanisole Zaprionus paravittiger 27 17.6   10 mM Y 9207858
N-acetyl-L-cysteine Caenorhabditis elegans 28.1 17.6 N2 CGCb strain 1 mM Y 26039957
Rapamycin Mus musculus 13 17.6 C57BL/6J.Nia 2 mg/kg every 5 days Y 27091134
Resveratrol Anastrepha ludens 2.6 17.5   100 µM N 19264118
Kinetin Zaprionus paravittiger -2.9 17.1   125 ppm Y 7488181
Vitamin E Paramecium tetraurelia 11.7 17.1   25 mg/L ND 9406982
L-deprenyl Rattus norvegicus 16.7 17 Fischer 344 0.0025 Y 2118586
Resveratrol Nothobranchius guentheri 42.9 17   12 µg Y 23220248
Caffeic acid phenethylester Caenorhabditis elegans 9 17     Y 24964141
Resveratrol Anastrepha ludens -2.3 16.7   100 µM N 19264118
Dehydroabietic acid Caenorhabditis elegans 10.3 16.7 N2 1 µM Y 25976661
Dehydroabietic acid Caenorhabditis elegans 15.5 16.7 N2 10 µM Y 25976661
Sodium Chloride Caenorhabditis elegans 19.59 16.67 N2 150 mM Y 26854551
Resveratrol Anastrepha ludens 1.3 16.6   100 µM N 19264118
Torin 1 Drosophila melanogaster 36.36 16.6 Dahomey 1 µM Y 29329306
L-deprenyl Mesocricetus auratus   16.4   0.05 mg/kg/day Y 9258898
LY-294002 Drosophila melanogaster 14.3 16.3 Canton S 5 µM Y 20017609
Quercetin Caenorhabditis elegans 8 16 N2 100 µM Y 19043800
Rhodiola rosea extract Drosophila melanogaster 24 16   25 mg/mL Y 19634056
Naphthazarin Caenorhabditis elegans 19 16 N2 200 µM Y 21765926
Triptolide Caenorhabditis elegans 20.1 16 N2 50 mg/L Y 28471052
Captopril Caenorhabditis elegans 34 16 N2 2.54 mM Y 26918946
Blueberry extract Caenorhabditis elegans 22.23 16 N2 50 mg/mL Y 30238944
Kinetin Zaprionus paravittiger 22.9 15.8   125 ppm Y 7488181
6-shogaol Caenorhabditis elegans 25.9 15.78 N2 25 µM Y 29978428
Cordyceps sinensis oral liquid Drosophila melanogaster 32 15.4 Oregon-K 0.20 mg/ml Y 26239097
Lithocholic acid Drosophila melanogaster 24.94 15.39 w1118 50 µM Y 30051966
Omega-3 Monoacylglyceride Docosahexaenoic acid Drosophila melanogaster 14.58 15.32 w1118 0.3 mg/mL Y 30453574
Propyl gallate Zaprionus paravittiger 8.7 15.3   25 µg/ml Y 8950031
L-deprenyl Mus musculus 2.7 15.3 B6D2F1 0.25 mg/kg 3x/week N 8914495
Withanolide A Caenorhabditis elegans 10.81 15.12 N2 50 µM Y 26956478
N-acetyl-L-cysteine Drosophila melanogaster 14.1 15.1 Oregon R 1 mg/ml ND 9447249
N-acetyl-L-cysteine Drosophila melanogaster 16.8 15.1 Oregon R 100 µg/ml Y 9447249
Quercetin Caenorhabditis elegans 19 15 N2 100 µM Y 18024103
Oxoline Caenorhabditis elegans 9 15 N2 100 µM N 21765926
Stachys lavandulifolia water extract Drosophila melanogaster 32 14.9 Oregon R 20 µl/100 ml media Y 20738162
Luteolin Caenorhabditis elegans 17.65 14.82 N2 100 µM Y 29375370
Melatonin Paramecium tetraurelia 20.8 14.8   10 mg/L Y 9406982
Astaxanthin Caenorhabditis elegans 20.8 14.6 N2 6 µg Y 22484623
Alpha-lipoic acid Caenorhabditis elegans 24.2 14.3 N2 24 µM Y 17156833
Resveratrol Caenorhabditis elegans 15.4 14.3 N2 50 µM Y 25976661
Glucose Caenorhabditis elegans 31.25 14.29 N2 2% Y 26764305
Polypeptide Pineal extract Mus musculus 31 14 C3H/Sn 0.5 mg Y 6752596
Rapamycin Mus musculus 13 14 Hybrid of CB6F1(F)& C3D2F1(M) 2.24 mg/kg/day Y 19587680
Stachys lavandulifolia ethanol extract Drosophila melanogaster 16 14 Oregon R 4 µl/100 ml media Y 20738162
Stachys lavandulifolia water extract Drosophila melanogaster 35.6 14 Oregon R 20 µl/100 ml media Y 20738162
Naphthazarin Caenorhabditis elegans 8 14 N2 200 µM Y 21765926
Oxoline Caenorhabditis elegans 15 14 N2 500 µM Y 21765926
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 16.8 14 Oregon R+   Y 25628774
10-hydroxy-2-decenoic Acid Caenorhabditis elegans 10 14 N2 25 µM Y 25789174
Resveratrol Anastrepha ludens 2.6 13.9   100 µM N 19264118
N-Acetyl Cysteine Drosophila kikkawai 16 13.9   100 µM Y 30243020
N-Acetyl Cysteine Drosophila kikkawai 16 13.9   1 mM Y 30243020
Torin 1 Drosophila melanogaster 50 13.89 Dahomey 5 µM Y 29329306
Electrolyzed reduced water Caenorhabditis elegans 17.3 13.8 N2   Y 23959012
Paraquat Caenorhabditis elegans 24.6 13.58 N2 200 µM Y 28992589
Dichloroacetate Caenorhabditis elegans 7.9 13.5 N2 50 µg/ml Y 21153705
Lithium Chloride Drosophila melanogaster 23 13.5 Dahomey 25 mM Y 27068460
Sodium hypophosphite Zaprionus paravittiger 13 13.3   10 µM Y 3721207
Tyrosine-Alanine Dipeptide Caenorhabditis elegans 10.37 13.04 N2 1 mM Y 26987062
Tyrosine-Alanine Dipeptide Caenorhabditis elegans 12.43 13.04 N2 10 mM Y 26987062
Epigallocatechin-3-gallate Caenorhabditis elegans 20 13 N2 100 µM N 20513639
Marine collagen peptides Rattus norvegicus 11 13 Sprague-Dawley 0.09 Y 20553190
Plumbagin Caenorhabditis elegans 11 13 N2 25 µM Y 21765926
Rosa damascena extract Drosophila melanogaster 31.7 13 B   Y 21928072
Curcumin Drosophila melanogaster 12.6 13 Oregon R 1 mg/g Y 22653297
N-(3-(aminomethyl)benzyl)acetamidine Drosophila melanogaster 3 13 Canton S 0.03 µM Y 24096697
Oxaloacetate Caenorhabditis elegans 25 13 N2 8 mM Y 19793063
Lithium Chloride Drosophila melanogaster 13 13 Dahomey 10 mM Y 27068460
Kinetin Zaprionus paravittiger 14.2 12.9   25 ppm Y 7488181
Rosa damascena extract Drosophila melanogaster 22.4 12.7 B   Y 21928072
S-allylmercapto-N-acetylcysteine Caenorhabditis elegans 8.38 12.5 CF512 0.5mM Y 29579097
Pyrroloquinoline quinone Caenorhabditis elegans 31.25 12.5 N2 5 mM Y 28676501
Glucose Caenorhabditis elegans -5.88 12.5 N2 1% N 26764305
Glucose Caenorhabditis elegans -5.88 12.5 N2 2% Y 26764305
Sodium hypophosphite Zaprionus paravittiger 13.2 12.4   10 µM Y 3721207
BP-C3 Mus musculus 8.4 12.4 Swiss-Derived SHR 10 mg/kg Daily Y 27574962
Gamma-tocopherol Caenorhabditis elegans 10.1 12.3 N2 43 µg Y 22484623
Indole Caenorhabditis elegans 15.91 12.3 N2 100 µM Y 28827958
Propyl gallate Zaprionus paravittiger 15.1 12.2   25 µg/ml Y 8950031
Naphthazarin Caenorhabditis elegans 11 12 N2 100 µM Y 21765926
Naphthazarin Caenorhabditis elegans 10 12 N2 100 µM Y 21765926
Oxoline Caenorhabditis elegans 15 12 N2 500 µM Y 21765926
Oxoline Caenorhabditis elegans 3 12 N2 500 µM Y 21765926
Plumbagin Caenorhabditis elegans 12 12 N2 50 µM Y 21765926
Sodium butyrate Drosophila melanogaster 8.3 12 Ra 10 mM Y 26136617
17‐α‐estradiol Mus musculus 19 12 UM-HET3 14.4 ppm of Chow Y 27312235
N-acetyl-L-cysteine Caenorhabditis elegans 12.53 12 N2 6 mM Y 27683245
Platanus orientalis Extract Drosophila melanogaster 13.02 11.94 Oregon R 0.1µg/ml Y 28887920
Ganoderma lucidum extract Caenorhabditis elegans 35.83 11.76 N2 7.5 mg/mL Y 30476533
5-octanoyl salicylic acid Caenorhabditis elegans 18.3 11.53 N2 100 µM Y 30192051
Resveratrol Caenorhabditis elegans 11 11.5 N2 100 ug/ml ND 21364612
2,5-Dimethyl-Celecoxib Drosophila melanogaster 8.4 11.32 Dahomey 0.5 µM Y 28025308
2-deoxy-D-glucose Caenorhabditis elegans 26.21 11.27 N2 5 mM Y 28992589
Polypeptide Bovine Thymus extract Mus musculus 28 11.2 C3H/Sn 0.5 mg Y 6752596
N-Acetyl Cysteine Drosophila kikkawai 16 11.1   1 µM Y 30243020
Epicatechin Caenorhabditis elegans 15 11 N2 100 µM N 20513639
Tocotrienol Caenorhabditis elegans 12 11 N2 259 µg Y 22484623
1-methyl nicotinamide Caenorhabditis elegans 7.7 11 N2 1 µM Y 24077178
Acarbose Mus musculus 22 11 UM-HET3 1000 mg/kg Y 24245565
Rapamycin Mus musculus 26 11 UM-HET3 42 mg of drug per kg of food Y 24341993
Rapamycin Mus musculus 21 11 UM-HET3 14 mg of drug per kg of food Y 24341993
N-Acetyl Cysteine Drosophila melanogaster 5.6 10.9 Canton-S 100 µM Y 30243020
Tyrosol Caenorhabditis elegans 19.1 10.8 fer-15(b26) 250 µM Y 22824366
Electrolyzed reduced water Caenorhabditis elegans 17.5 10.7 N2   Y 23959012
Stachys lavandulifolia water extract Drosophila melanogaster 22.1 10.6 Oregon R 12 µl/100 ml media Y 20738162
Selenocysteine Caenorhabditis elegans 24.34 10.52 N2 5 mM Y 28954009
Vitexin Caenorhabditis elegans 17.2 10.5 N2 100 µM Y 26535084
L-Glu-L-Trp dipeptide Rattus norvegicus 0 10.4   5 µg/rat. 5 times a week ND 11707921
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 15.5 10.4 Oregon R+   Y 25628774
Royal Jelly Protein Drosophila melanogaster 13.87 10.34 Canton-S 5% Y 27388939
Pyrroloquinoline quinone Caenorhabditis elegans 25 10.3 N2 10 mM Y 28676501
Resveratrol Anastrepha ludens -5.6 10.2   100 µM N 19264118
Resveratrol Anastrepha ludens 1.5 10   100 µM N 19264118
Oxoline Caenorhabditis elegans 15 10 N2 500 µM Y 21765926
Psoralea corylifolia extract Caenorhabditis elegans   9.8 N2 10 µg/mL Y 19350411
N-Acetyl Cysteine Drosophila virilis 26 9.8   100 µM Y 30243020
N-acetyl-L-cysteine Caenorhabditis elegans 5.2 9.5 N2 CGCb strain 2 mM N 26039957
N-acetyl-L-cysteine Caenorhabditis elegans 6.1 9.5 N2 CGCb strain 1 mM N 26039957
Rapamycin Mus musculus 10.1 9.3 129/Sv 1.5 mg/kg Y 22107964
Resveratrol Caenorhabditis elegans 12.8 9.1 N2 10 µM Y 25976661
Resveratrol Caenorhabditis elegans 6.3 9.1 N2 1 µM N 25976661
Sodium butyrate Drosophila melanogaster 14.6 9.1 Ra 10 mM Y 26136617
Quercetin Caenorhabditis elegans 11 9 N2 200 µM Y 19043800
Glaucarubinone Caenorhabditis elegans 7.9 9 N2 100 nM Y 21264793
Acarbose Mus musculus 5 9 UM-HET3 1000 mg/kg diet Y 24245565
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 13.9 8.9 Oregon R+   Y 25628774
Aronia extract Drosophila melanogaster 15.38 8.88 Canton-S 2.5 mg/mL Y 30263675
N-Acetyl Cysteine Drosophila virilis 24 8.8   1 mM Y 30243020
Curcumin Drosophila melanogaster 6.74 8.77 Canton-S 0.2 mg/g Y 30488487
α‐linolenic acid Caenorhabditis elegans 28.67 8.7 N2 5 mM Y 28772063
α‐linolenic acid Caenorhabditis elegans 28.67 8.7 N2 5 mM Y 28772063
East Indian sandalwood oil Caenorhabditis elegans 8.59 8.69 N2 6 µ/mL Y 30319772
N-Acetyl Cysteine Drosophila virilis 31 8.69   100 nM Y 30243020
N-Acetyl Cysteine Drosophila virilis 32.4 8.6   10 nM Y 30243020
Torin 1 Drosophila melanogaster 27.27 8.33 Dahomey 0.5 µM Y 29329306
α-Santalol Caenorhabditis elegans 10.31 8.33 N2 32 µM Y 30319772
α-Santalol Caenorhabditis elegans 18.04 8.33 N2 32 µM Y 30319772
β-Santalol Caenorhabditis elegans 2.66 8.33 N2 8 µM N 30319772
β-Santalol Caenorhabditis elegans 3.78 8.33 N2 32µM N 30319772
β-Santalol Caenorhabditis elegans 4.64 8.33 N2 64 µM Y 30319772
Dehydroabietic acid Caenorhabditis elegans 4.8 8.3 N2 50 µM N 25976661
N-Acetyl Cysteine Drosophila kikkawai 12 8.3   100 nM Y 30243020
Luteolin Caenorhabditis elegans -1.54 8.28 N2 1 µM Y 29375370
Luteolin Caenorhabditis elegans -0.6 8.28 N2 5 µM Y 29375370
Pyrroloquinoline quinone Caenorhabditis elegans 19.53 8.15 N2 3 mM Y 28676501
Stachys lavandulifolia ethanol extract Drosophila melanogaster 44.4 8 Oregon R 20 µl/100 ml media Y 20738162
Stachys lavandulifolia water extract Drosophila melanogaster 21.9 8 Oregon R 12 µl/100 ml media Y 20738162
Naphthazarin Caenorhabditis elegans 10 8 N2 200 µM Y 21765926
Naphthazarin Caenorhabditis elegans 14 8 N2 500 µM Y 21765926
Lonidamine Caenorhabditis elegans 8 8   5 µM Y 21932172
Chicoric acid Caenorhabditis elegans 21 8 N2 100 µM Y 24244361
Rapamycin Mus musculus 23 8 UM-HET3 42 mg of drug per kg of food Y 24341993
D-glucosamine Caenorhabditis elegans 11 8 N2 10 mM Y 24714520
Rapamycin Mus musculus 13 8 UM-HET3 14 mg of drug per kg of food Y 24341993
Selenocysteine Caenorhabditis elegans 24.16 7.9 N2 1 mM Y 28954009
Selenocysteine Caenorhabditis elegans 21.72 7.9 N2 2.5 mM Y 28954009
N-Acetyl Cysteine Drosophila melanogaster 9.3 7.8 Canton-S 100 nM Y 30243020
Aronia extract Drosophila melanogaster 0 7.77 Canton-S 1 mg/mL N 30263675
Recombinant GDF11 Nothobranchius guentheri 8.51 7.69   0.2 mg/kg Y 30519861
N-Acetyl Cysteine Drosophila virilis 31 7.6   1 µM Y 30243020
N-Acetyl Cysteine Drosophila virilis 29.6 7.6   10 µM Y 30243020
N-Acetyl Cysteine Drosophila virilis 31 7.6   100 µM Y 30243020
Withanolide A Caenorhabditis elegans 4.32 7.59 N2 2 µM Y 26956478
L-deprenyl Mus musculus 7 7.5 B6CBAF1 0.25 mg/kg 3x/week N 8914495
Melatonin Mus musculus 5.4 7.5 CBA 20 mg/l Y 11445596
Platanus orientalis Extract Drosophila melanogaster 2.43 7.46 Oregon R 10 µg/ml Y 28887920
Rosa damascena extract Drosophila melanogaster 4.5 7.4 w1118   N 21928072
L-Leucine Caenorhabditis elegans 6.84 7.32 N2 5 mM Y 26620638
Resveratrol Anastrepha ludens 6.2 7.3   100 µM N 19264118
Chlorpheniramine Mus musculus -3.3 7.2 C57BL/6J 2.28 µg/mL N 4788962
Prunetin Drosophila melanogaster 5.19 7.17 w1118 25 µM Y 26538555
Glucose Caenorhabditis elegans 37.5 7.14 N2 4% Y 26764305
Naphthazarin Caenorhabditis elegans 8 7 N2 100 µM Y 21765926
Butylated hydroxyanisole Zaprionus paravittiger 7.9 6.9   5 mM Y 9207858
Royal Jelly Protein Drosophila melanogaster 8.96 6.9 Canton-S 1.25% Y 27388939
N-Acetyl Cysteine Drosophila virilis 22.6 6.9   10 nM Y 30243020
N-Acetyl Cysteine Drosophila virilis 16 6.9   1 µM Y 30243020
N-Acetyl Cysteine Drosophila virilis 22.7 6.9   10 µM Y 30243020
Naringin Caenorhabditis elegans 11.5 6.8 N2 10 µM Y 29375370
Ascorbic acid Paramecium tetraurelia 12.1 6.7   50 mg/L ND 9406982
Vitamin E Asplanchna brightwelli 16.4 6.7 clone 4B61 3 mM Y 15374519
Butylated hydroxyanisole Zaprionus paravittiger 18.4 6.6   5 mM Y 9207858
Rhodiola rosea Drosophila melanogaster 16.7 6.6 IF 5 mg/ml Y 24472572
Omega-3 Monoacylglyceride Docosahexaenoic acid Drosophila melanogaster 14.58 6.56 w1118 0.3 mg/mL Y 30453574
Tetrahydrocurcumin Mus musculus 10.7 6.5 C57BL/6J 0.002 Y 17516143
L-isoleucine Caenorhabditis elegans 9.5 6.45 N2 5 mM Y 26620638
Ascorbic acid Caenorhabditis elegans -3.59 6.45 N2 5 mM Y 27683245
Stachys lavandulifolia ethanol extract Drosophila melanogaster 12.4 6.4 Oregon R 4 µl/100 ml media Y 20738162
Rosa damascena extract Drosophila melanogaster 14.5 6.4 w1118   Y 21928072
Sodium hypophosphite Zaprionus paravittiger 1 6   1 µM Y 3721207
Plumbagin Caenorhabditis elegans 11 6 N2 25 µM Y 21765926
Nicotinamide Caenorhabditis elegans 6.5 6 N2 100 µM Y 24077178
Methylene blue Mus musculus 0.7 6 UM-HET3 27 mg/kg diet Y 24245565
Rhodiola rosea Drosophila melanogaster 14.3 6 IF 10 mg/ml Y 24472572
Icariin Mus musculus 8 6 C57BL/6J 0.02% in food N 26145038
Rapamycin Mus musculus 3 6 UM-HET3 4.7 mg of drug per kg of food N 24341993
Protandim Mus musculus 7 6 UM-HET3 600 ppm in chow Y 27312235
Pyrroloquinoline quinone Caenorhabditis elegans 10 6 N2 15 mM Y 28676501
Quercetin Drosophila melanogaster 13 6 Canton S 1 µM Y 28066251
Tiliroside Drosophila melanogaster 15.56 5.88 Oregon R 100 µM Y 28887920
Sodium hypophosphite Zaprionus paravittiger 5.3 5.7   1 µM Y 3721207
Resveratrol Anastrepha ludens 3.8 5.7   100 µM N 19264118
Baicalein Drosophila melanogaster 8.53 5.7 w1118 0.04mg/ml Y 26778291
Naproxen Brachionus manjavacas 13.93 5.56   1 µM Y 27484416
Buformin Rattus norvegicus 7 5.5 LIO 5 mg/day Y 14618027
D-glucosamine Mus musculus 5.6 5.5 C57BL/6NRj 10 g/kg Y 24714520
Chlorpromazine Mus musculus -0.2 5.5 C57BL/6J 16.7 µg/mL N 4788962
Resveratrol Anastrepha ludens -4.9 5.4   100 µM N 19264118
Green tea extract Drosophila melanogaster 7.8 5.3 Oregon-R-C 5 mg/ml Y 17440995
Green tea extract Drosophila melanogaster 15.7 5.3 Oregon-R-C 10 mg/ml Y 17440995
Green tea extract Drosophila melanogaster 5.9 5.3 Oregon-R-C 1 mg/ml Y 17440995
Vitexin Caenorhabditis elegans 8 5.3 N2 50 µM Y 26535084
Pine Bark extract Caenorhabditis elegans   5.2 N2 10 µg/mL Y 19350411
Royal Jelly Protein Drosophila melanogaster 12.43 5.17 Canton-S 2.50% Y 27388939
Melatonin Paramecium tetraurelia 10.8 5.1   10 mg/L ND 9406982
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 1 5.1 Oregon R+   N 25628774
Cranberry anthocyanin extract Drosophila melanogaster 10.4 5.1 Oregon-R-C 20 mg/ml Y 26159161
N-tert-butyl-alpha-phenylnitrone Mus musculus 3.8 5 C57BL/6J 0.25 mg/ml of water Y 9614711
Alpha-lipoic acid Drosophila melanogaster 12 5 Canton S 0.01% ND 15328413
Resveratrol Anastrepha ludens 2.3 5   100 µM N 19264118
Oxoline Caenorhabditis elegans 2 5 N2 100 µM N 21765926
Plumbagin Caenorhabditis elegans 3 5 N2 2.5 µM N 21765926
Plumbagin Caenorhabditis elegans 15 5 N2 25 µM Y 21765926
Plumbagin Caenorhabditis elegans 12 5 N2 50 µM Y 21765926
Rapamycin Mus musculus 16 5 UM-HET3 4.7 mg of drug per kg of food Y 24341993
Curcumin Drosophila melanogaster 3.01 4.91 Canton-S 0.2 mg/g N 30488487
N-Acetyl Cysteine Drosophila virilis 18.7 4.9   100 nM Y 30243020
Epigallocatechin-3-gallate Caenorhabditis elegans 4.8 4.8 N2 25 µM N 17156833
trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene Caenorhabditis elegans 3.63 4.76 N2 100 µM Y 27882602
2-Selenium-bridged β-cyclodextrin Caenorhabditis elegans 7.24 4.76 N2 0.5 mM Y 101039
2-Selenium-bridged-beta-cyclodextrin Caenorhabditis elegans 7.24 4.76 N2 0.5 mM Y 101039
2-Selenium-bridged-beta-cyclodextrin Caenorhabditis elegans 8.69 4.76 N2 5 mM Y 101039
Ribes fasciculatum eylacetate fraction Caenorhabditis elegans 11.1 4.76 N2 250 µg/mL Y 27478096
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 5.3 4.7 Oregon R+   N 25628774
N-Acetyl Cysteine Drosophila melanogaster 5.6 4.7 Canton-S 10 nM Y 30243020
N-Acetyl Cysteine Drosophila melanogaster 7.4 4.7 Canton-S 1 µM Y 30243020
Baicalein Drosophila melanogaster 9.32 4.66 w1118 1 mg/ml Y 26778291
Branched-Chain Amino Acids Mus musculus 12 4.6 B6.129S2 1.5 mg/g body weight Y 20889128
Butylated hydroxyanisole Zaprionus paravittiger 13.1 4.4   25 mM Y 9207858
L-theanine Caenorhabditis elegans 3.6 4.4 N2 0.1 µM Y 22422488
Fucoxanthin Drosophila melanogaster 14.9 4.4 Canton S 1 µM Y 29504896
α‐linolenic acid Caenorhabditis elegans 10.49 4.35 N2 2 mM Y 28772063
East Indian sandalwood oil Caenorhabditis elegans 0.94 4.34 N2 3 µ/mL N 30319772
East Indian sandalwood oil Caenorhabditis elegans 4.22 4.34 N2 48 µ/mL N 30319772
Naringin Caenorhabditis elegans 13.5 4.08 N2 1 µM Y 29375370
Naringin Caenorhabditis elegans 12.57 4.08 N2 5 µM Y 29375370
Naphthazarin Caenorhabditis elegans 9 4 N2 500 µM N 21765926
Epigallocatechin-3-gallate Caenorhabditis elegans 7.11 4 N2 300 µM Y 28992589
Lithium Chloride Drosophila melanogaster 18.5 4 Dahomey 10 mM Y 27068460
Isoprenol Caenorhabditis elegans 7.81 4 N2 0.1 mM Y 30624146
Baicalein Drosophila melanogaster 19.8 3.97 w1118 0.2mg/ml Y 26778291
Rhodiola rosea Drosophila melanogaster 13.6 3.9 IF 10 mg/ml Y 24472572
Torin 1 Drosophila melanogaster 4.55 3.8 Dahomey 1 µM Y 29329306
Pyrroloquinoline quinone Caenorhabditis elegans 10.16 3.8 N2 1 mM Y 28676501
Resveratrol Anastrepha ludens -0.5 3.7   100 µM N 19264118
Sesame Cake Peptides Caenorhabditis elegans 15.59 3.57 N2 12.5 µg/ml Y 27381188
Sesame Cake Peptides Caenorhabditis elegans 13.29 3.57 N2 25 µg/ml Y 27381188
Sesame Cake Peptides Caenorhabditis elegans 5.2 3.57 N2 50 µg/ml Y 27381188
Creatine Mus musculus 8.9 3.5 C57BL/6J 0.01 Y 17416441
Tocotrienol Caenorhabditis elegans 8.6 3.5 N2 26 µg Y 22484623
Rhodiola rosea Drosophila melanogaster 13.6 3.4 IF 5 mg/ml Y 24472572
2,5-Dimethyl-Celecoxib Drosophila melanogaster 9.07 3.39 Dahomey 0.5 µM Y 28025308
Epigallocatechin-3-gallate Caenorhabditis elegans 16.6 3.14 N2 200 µM Y 28992589
Resveratrol Caenorhabditis elegans 16.66 3.13 N2 250 µM Y 27683245
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 5.7 3.1 Oregon R+   N 25628774
Epicatechin Drosophila melanogaster 6.95 3.08 Canton S 0.5 µM Y 28066251
Plumbagin Caenorhabditis elegans 1 3 N2 1 µM N 21765926
Plumbagin Caenorhabditis elegans 3 3 N2 5 µM N 21765926
Plumbagin Caenorhabditis elegans 7 3 N2 10 µM N 21765926
Curcumin Drosophila melanogaster -17 3 Ra 100 mM Y 23063786
Icariin in Epimedium Flavonoid Mus musculus 4 3 C57BL/6J 0.06% in food N 26145038
Proanthocyanidins from Kunlun Chrysanthemum flowers Drosophila melanogaster 3.2 2.9 Oregon R+   N 25628774
N-Acetyl Cysteine Drosophila virilis 31 2.9   1 mM Y 30243020
Luteolin Caenorhabditis elegans 0.47 2.76 N2 10 µM Y 29375370
Nectarine Drosophila melanogaster 17.6 2.7 Canton S 0.04 Y 21406223
Rhodiola rosea Bombyx mori 2.7 2.7 N4   Y 26497336
4-dafachronic acid Caenorhabditis elegans 0 2.6 N2 250 nM Y 17360327
Diethyl Maleate Caenorhabditis elegans 4.64 2.33 N2 100 µM Y 28086197
Epicatechin Drosophila melanogaster 0 2.24 Canton S 0.5 µM N 28066251
Butylated hydroxyanisole Zaprionus paravittiger 20.5 2.2   25 mM Y 9207858
Metformin Rattus norvegicus 2.3 2.1 Fischer 344 300 mg/kg/day N 20304770
Plumbagin Caenorhabditis elegans 9 2 N2 10 µM N 21765926
Plumbagin Caenorhabditis elegans 10 2 N2 25 µM N 21765926
Plumbagin Caenorhabditis elegans 1 2 N2 100 µM N 21765926
Rhodiola rosea Bombyx mori 1.5 1.6 N4   Y 26497336
N-Acetyl Cysteine Drosophila melanogaster 3.7 1.6 Canton-S 1 mM Y 30243020
Platanus orientalis Extract Drosophila melanogaster 3.26 1.49 Oregon R 1 µg/ml Y 28887920
J147 Drosophila melanogaster 10.35 1.39 (w1118/+) 0.1µM Y 29316249
Butylated hydroxyanisole Zaprionus paravittiger 4 1.3   1 mM N 9207858
Green tea polyphenols Mus musculus 6.4 1.3 C57BL/6J 80 mg/l Y 17516143
L-deprenyl Rattus norvegicus 5.6 1 F344/DuCrj 0.5 mg/kg. 3 times a week Y 8030852
Oxoline Caenorhabditis elegans 2 1 N2 50 µM N 21765926
Butylated hydroxyanisole Zaprionus paravittiger 1.7 0.8   1 mM N 9207858
Cortisone Asplanchna brightwelli -3.2 0 clone 4B61 400 µM N 2782995
Cortisone Asplanchna brightwelli -6.3 0 clone 4B61 800 µM N 2782995
Cortisone Asplanchna brightwelli 2.2 0 clone 4B61 50 µM N 2782995
Cortisone Asplanchna brightwelli 20.8 0 clone 4B61 100 µM Y 2782995
Cortisone Asplanchna brightwelli 0.7 0 clone 4B61 10 µM N 2782995
Cortisone Asplanchna brightwelli 19.3 0 clone 4B61 200 µM Y 2782995
Vitamin E Philodina 9.2 0   concentration of 10^ -4 N 7428854
Kinetin Zaprionus paravittiger -20 0   625 ppm N 7488181
3,3'-thiodipropionic acid Asplanchna brightwelli 10 0 clone 4B61 2 mM Y 15374519
Aurintricarboxylic acid Drosophila melanogaster 15 0 Oregon R 0.5 mM ND 15621204
2,4-dinitrophenol Drosophila melanogaster 20.2 0 Oregon R 0.008 ND 16266268
Vitamin E Caenorhabditis elegans 20.6 0 N2 200 µg/mL Y 17169403
Vitamin E Caenorhabditis elegans 16.6 0 N2 20 µg/mL Y 17169403
Alpha-lipoic acid Caenorhabditis elegans 21 0 N2 1 mM Y 18755260
Propyl gallate Caenorhabditis elegans 12 0 N2 1 mM Y 18755260
Quercetin Caenorhabditis elegans 9 0 N2 200 µM Y 19043800
Metformin Caenorhabditis elegans 40 0 N2 50 mM Y 20090912
Electrolyzed reduced water Caenorhabditis elegans 41 0 N2   Y 20944427
Naphthazarin Caenorhabditis elegans 2 0 N2 50 µM N 21765926
Plumbagin Caenorhabditis elegans 0 0 N2 7.5 µM N 21765926
Curcumin Drosophila melanogaster 25.5 0 Ra 100 mM Y 23063786
Sulfamethoxazole Caenorhabditis elegans 18 0 N2 400 µM Y 24034891
Sulfamethoxazole Caenorhabditis elegans 34 0 N2 100 µM Y 24034891
Sulfamethoxazole Caenorhabditis elegans 28 0 N2 200 µM Y 24034891
Lithium Chloride Caenorhabditis elegans 0.1 0 JK1107 10 mM ND 24398558
Curcumin Drosophila melanogaster 25.5 0 Ra 100 mM Y 26136617
Cranberry anthocyanin extract Drosophila melanogaster 6.3 0 Oregon-R-C 5 mg/ml Y 26159161
Fucoxanthin Drosophila melanogaster 6.2 0 Canton S 1 µM Y 29504896
Torin 1 Drosophila melanogaster 59.09 0 Dahomey 10 µM Y 29329306
L-Valine Caenorhabditis elegans 7.05 0 N2 5 mM Y 26620638
Casein Drosophila melanogaster 4.34 0 Canton-S 1.25% Y 27388939
Glucose Caenorhabditis elegans 0 0 N2 2% N 26764305
Glucose Caenorhabditis elegans 12.5 0 N2 1% N 26764305
Hydralazine Brachionus manjavacas 9.01 0   1 µM Y 27484416
α-Santalol Caenorhabditis elegans 4.33 0 N2 16 µM N 30319772
α-Santalol Caenorhabditis elegans 0.94 0 N2 64 µM N 30319772
β-Santalol Caenorhabditis elegans -2.73 0 N2 4 µM N 30319772
N-Acetyl Cysteine Drosophila kikkawai 16 0   10 µM Y 30243020
N-Acetyl Cysteine Drosophila kikkawai 5.1 0   10 nM Y 30243020
Naringin Caenorhabditis elegans 6.95 -0.68 N2 0.5 µM Y 29375370
L-deprenyl Mus musculus -0.1 -0.7 B6D2F1 0.25 mg/kg 3x/week N 8914495
D-glucose Caenorhabditis elegans -7.75 -0.9 N2 50 mM Y 17908557
Sodium hypophosphite Zaprionus paravittiger -4.1 -1.4   10 mM N 3721207
Resveratrol Anastrepha ludens 11.2 -1.4   100 µM N 19264118
Sodium hypophosphite Zaprionus paravittiger -8.3 -1.7   10 mM Y 3721207
Curcumin Drosophila melanogaster 15.5 -1.9 Oregon R 0.5 mg/g Y 22653297
Ethosuximide Caenorhabditis elegans 14 -2 N2 4 mg/ml Y 15653505
Quercetin Caenorhabditis elegans 10 -2 N2 200 µM Y 19043800
N-Acetyl Cysteine Drosophila kikkawai 5.1 -2   100 nM Y 30243020
Luteolin Caenorhabditis elegans -4.5 -2.03 N2 0.5 µM Y 29375370
Epicatechin Drosophila melanogaster -11.44 -2.21 Canton S 1 µM Y 28066251
Epigallocatechin-3-gallate Caenorhabditis elegans 13.44 -2.29 N2 100 µM Y 28992589
Rapamycin Drosophila melanogaster 16.35 -2.89 Dahomey 5 µM Y 28025308
Rapamycin Drosophila melanogaster 12.98 -2.89 Dahomey 10 µM Y 28025308
Rhodiola rosea Drosophila melanogaster 6.8 -2.9 IF 2.5 mg/ml N 24472572
Quercetin Caenorhabditis elegans 8 -3 N2 100 µM N 19043800
Curcumin Drosophila melanogaster -17 -3 Ra 100 mM Y 26136617
Metformin Mus musculus -5 -3 C57BL/6 1%in Standard Diet on 2 Consecutive Weeks Each Month ND 29167747
Resveratrol Anastrepha ludens 0 -3.4   100 µM N 19264118
Freeze dried royal jelly Drosophila melanogaster 8.5 -4 Oregon R 1% w/v Y 23132575
α-Santalol Caenorhabditis elegans 0.63 -4.16 N2 4 µM N 30319772
α-Santalol Caenorhabditis elegans 2.57 -4.16 N2 8 µM N 30319772
α‐linolenic acid Caenorhabditis elegans 15.13 -4.34 N2 10 mM Y 28772063
α‐linolenic acid Caenorhabditis elegans 15.13 -4.34 N2 10 mM Y 28772063
Epicatechin Drosophila melanogaster -3.78 -4.48 Canton S 1 µM Y 28066251
Resveratrol Anastrepha ludens -2.8 -4.8   100 µM N 19264118
Aspirin (Bufferin) Mus musculus 0.1 -4.8 C57BL/6J 495 µg/mL N 4788962
Curcumin Drosophila melanogaster 25.8 -5.2 Oregon R 1 mg/g Y 22653297
Curcumin Drosophila melanogaster 6.2 -5.2 Oregon R 0.5 mg/g N 22653297
Epicatechin Drosophila melanogaster -6.49 -5.22 Canton S 0.3µM Y 28066251
Resveratrol Drosophila melanogaster -9.9 -5.28 w1118 500 µmol/L N 29324667
Plumbagin Caenorhabditis elegans -3 -6 N2 50 µM N 21765926
Rhodiola rosea Drosophila melanogaster 2.4 -6 IF 2.5 mg/ml N 24472572
Metformin Mus musculus -1 -6 C57BL/6 1% In Standard Diet Every Other Week ND 29167747
Aspirin (Bufferin) Mus musculus 5 -6.1 C57BL/6J 113 µg/mL N 4788962
Menadione Caenorhabditis elegans -8.72 -6.36 N2 100 µM Y 28086197
Diethyl Maleate Caenorhabditis elegans -6.68 -6.4 N2 1 mM Y 28086197
Quercetin Drosophila melanogaster -4.55 -6.7 Canton S 0.5 µM Y 28066251
Resveratrol Anastrepha ludens -5.8 -7.3   100 µM N 19264118
Resveratrol Anastrepha ludens 2.5 -7.7   100 µM N 19264118
Quercetin Caenorhabditis elegans 10 -8 N2 200 µM N 19043800
Oxoline Caenorhabditis elegans 2 -8 N2 100 µM N 21765926
Sodium hypophosphite Zaprionus paravittiger -24.2 -8.1   60 mM Y 3721207
Quercetin Drosophila melanogaster -5.09 -8.2 Canton S 0.3µM Y 28066251
Quercetin Drosophila melanogaster -10.2 -8.21 Canton S 1 µM Y 28066251
J147 Drosophila melanogaster 12.5 -8.33 (w1118/+) 2 µM Y 29316249
Glucose Caenorhabditis elegans -17.65 -8.33 N2 4% Y 26764305
Resveratrol Anastrepha ludens -25.3 -9.5   100 µM Y 19264118
Dimethylaminoethyl p-chlorophenoxyacetate Mus musculus 5.9 -9.6 C57BL/6J 702 µg/mL N 4788962
Trimethadione Caenorhabditis elegans -7 -10 N2 4 mg/ml N 15653505
Epicatechin Drosophila melanogaster -9.08 -10 Canton S 0.3µM Y 28066251
Aspirin (Bufferin) Mus musculus -17.5 -10.1 C57BL/6J 242 µg/mL Y 4788962
Chloroquine Mus musculus -16.8 -10.8 C57BL/6J 13.2 µg/mL Y 4788962
Epigallocatechin-3-gallate Caenorhabditis elegans -7.9 -10.85 N2 800 µM Y 28992589
Acetaminophen Mus musculus 3.7 -11 C57BL/6J 242 µg/mL N 4788962
Sodium hypophosphite Zaprionus paravittiger -24.4 -11.2   60 mM Y 3721207
Sodim cyclamate Rattus norvegicus 9.77 -11.28 Wistar 0.43/100 g Y 5132583
Caffeine Drosophila melanogaster -22.86 -11.6 Canton-S 0.03% Y 29093334
Caffeine Drosophila melanogaster -17.14 -11.6 Canton-S 0.05% Y 29093334
Resveratrol Anastrepha ludens -1.4 -12   100 µM N 19264118
Resveratrol Anastrepha ludens -3.3 -12.1   100 µM N 19264118
Rhodiola rosea Drosophila melanogaster -9.1 -12.2 IF 30 mg/ml Y 24472572
Resveratrol Anastrepha ludens -4.6 -12.4   100 µM N 19264118
Galactose Drosophila melanogaster -12.6 -12.9   6.50% Y 15547319
Ascorbic acid Caenorhabditis elegans -0.76 -12.9 N2 10 mM N 27683245
Plumbagin Caenorhabditis elegans -11 -13 N2 100 µM Y 21765926
Quercetin Drosophila melanogaster -2.8 -13.07 Canton S 0.3µM Y 28066251
Epigallocatechin-3-gallate Caenorhabditis elegans -16.6 -13.14 N2 1 mM Y 28992589
Kinetin Zaprionus paravittiger -2.9 -13.2   625 ppm Y 7488181
Quercetin Drosophila melanogaster -12 -13.84 Canton S 0.5 µM Y 28066251
Resveratrol Anastrepha ludens -14.5 -14.4   100 µM N 19264118
Quercetin Drosophila melanogaster -13.79 -14.62 Canton S 1 µM Y 28066251
Chlorpheniramine Mus musculus 1.4 -14.7 C57BL/6J 0.762 µg/mL N 4788962
Plumbagin Caenorhabditis elegans -16 -15 N2 100 µM Y 21765926
Chloroquine Mus musculus 0.3 -15 C57BL/6J 39.5 µg/mL N 4788962
Rhodiola rosea Drosophila melanogaster -11.9 -16.4 IF 30 mg/ml Y 24472572
Galactose Drosophila melanogaster -15.9 -17.1   6.50% Y 15547319
Glucose Caenorhabditis elegans -23.6 -17.24 N2 4% Y 26764305
Glucose Caenorhabditis elegans -23.75 -20.97 N2 2% Y 26764305
Galactose Musca domestica -19.8 -21.9   20 mg/ml Y 15547319
Taurine Drosophila melanogaster -14.29 -23.19 Canton-S 1.50% Y 29093334
Resveratrol Saccharomyces cerevisiae -34.8 -25 W303-1A 100 µM Y 28412652
Galactose Musca domestica -27.1 -27.1   20 mg/ml Y 15547319
Butylated hydroxyanisole Zaprionus paravittiger -45.9 -40.7   50 mM Y 9207858
Butylated hydroxyanisole Zaprionus paravittiger -31.7 -46.3   50 mM Y 9207858
Kinetin Zaprionus paravittiger -71 -47.1   3125 ppm Y 7488181
Sodium hypophosphite Zaprionus paravittiger -46.9 -47.2   100 mM Y 3721207
Butylated hydroxyanisole Zaprionus paravittiger -63.8 -53.7   100 mM Y 9207858
Sodium hypophosphite Zaprionus paravittiger -58.8 -54.8   100 mM Y 3721207
Kinetin Zaprionus paravittiger -65.7 -55.2   3125 ppm Y 7488181
Butylated hydroxyanisole Zaprionus paravittiger -57.2 -55.2   100 mM Y 9207858
Sodium hypophosphite Zaprionus paravittiger -84.1 -78.1   500 mM Y 3721207
Sodium hypophosphite Zaprionus paravittiger -85.3 -78.6   500 mM Y 3721207
Sodium hypophosphite Zaprionus paravittiger -88.5 -91.4   1 mM Y 3721207
Sodium hypophosphite Zaprionus paravittiger -89.8 -94.9   1 mM Y 3721207
Calcium gluconate Drosophila melanogaster -3.7   Oregon R 0.001 M ND 110607
Calcium gluconate Drosophila melanogaster -13.2   Oregon R 0.01 M ND 110607
Calcium lactate Drosophila melanogaster -10.7   Oregon R 0.01 M ND 110607
Calcium gluconate Drosophila melanogaster -56.6   Oregon R 0.1 M ND 110607
Calcium lactate Drosophila melanogaster 1.8   Oregon R 0.001 M ND 110607
Gluconic acid Drosophila melanogaster -9.3   Oregon R 1 M ND 110607
Gluconic acid Drosophila melanogaster -5.2   Oregon R 0.1 M ND 110607
Gluconic acid Drosophila melanogaster 0   Oregon R 0.01 M ND 110607
Gluconic acid Drosophila melanogaster 0   Oregon R 0.001 M ND 110607
Calcium lactate Drosophila melanogaster -66.1   Oregon R 0.1 M ND 110607
Gluconic acid Drosophila melanogaster -1.8   Oregon R 0.001 M ND 110607
Gluconic acid Drosophila melanogaster 0   Oregon R 0.5M 2x/week ND 110607
Gluconic acid Drosophila melanogaster 3.8   Oregon R 0.25M 2x/week ND 110607
Gluconic acid Drosophila melanogaster 3.8   Oregon R 0.01M 2x/week ND 110607
Gluconic acid Drosophila melanogaster 5.3   Oregon R 0.01 M ND 110607
Gluconic acid Drosophila melanogaster 9.3   Oregon R 0.5 M ND 110607
Gluconic acid Drosophila melanogaster 12.3   Oregon R 0.1 M ND 110607
Gluconic acid Drosophila melanogaster 20.8   Oregon R 0.1 M ND 110607
Gluconic acid Drosophila melanogaster 14.3   Oregon R 0.1 M ND 110607
Lactic acid Drosophila melanogaster -1.9   Oregon R 0.5M ND 110607
Lactic acid Drosophila melanogaster -32.7   Oregon R 1 M ND 110607
Gluconic acid Drosophila melanogaster 22.2   Oregon R 0.25 M ND 110607
Gluconic acid Drosophila melanogaster 7.2   Oregon R 0.01 M ND 110607
Lactic acid Drosophila melanogaster 3.6   Oregon R 0.01M ND 110607
Lactic acid Drosophila melanogaster 3.6   Oregon R 0.001 M ND 110607
Lactic acid Drosophila melanogaster 14   Oregon R 0.1M ND 110607
Lactic acid Drosophila melanogaster 8   Oregon R 0.001 M ND 110607
Lactic acid Drosophila melanogaster 12   Oregon R 0.01M ND 110607
Lactic acid Drosophila melanogaster 15.5   Oregon R 0.1M ND 110607
Tartaric acid Drosophila melanogaster 0   Oregon R 0.001 M ND 110607
Tartaric acid Drosophila melanogaster -72   Oregon R 0.1M ND 110607
Tartaric acid Drosophila melanogaster 6   Oregon R 0.01M ND 110607
Lactic acid Drosophila melanogaster 15.4   Oregon R 0.25M ND 110607
Diiodomethane Drosophila melanogaster 29.3     10 µg/ml ND 412727
Polypeptide Pineal extract Rattus norvegicus 25     0.5 mg, 5 times a week Y 575333
Citrate Mytilina brevispina 51.7     0.25% on alternate days ND 804507
Butylated hydroxytoluene Mus musculus 30.1   BaLB/c 0.75% Y 448040
Edetate Calcium Disodium Mytilina brevispina 49.4     0.25% on alternate days ND 804507
Butylated hydroxytoluene Mus musculus 24.8   BaLB/c 0.75% Y 448040
Tartrate Mytilina brevispina 43.7     0.25% on alternate days ND 804507
EGTA Mytilina brevispina 75.9     0.25% on alternate days ND 804507
Ascorbic acid Caenorhabditis elegans 0   N2 80 µg/ml N 3374177
Vitamin E Caenorhabditis elegans 4   N2 400 µg/ml N 3374177
Vitamin E Caenorhabditis elegans 9   N2 100 µg/ml N 3374177
Vitamin E Caenorhabditis elegans 22   N2 200 µg/ml Y 3374177
Vitamin E Caenorhabditis elegans 17   N2 200 µg/ml Y 3374177
Vitamin E Caenorhabditis elegans 17   N2 200 µg/ml Y 3374177
Vitamin E Caenorhabditis elegans 23   N2 200 µg/ml Y 3374177
Nordihydroguaiaretic acid Aedes aegypti 42.7     0.001% (w/v) Y 3749035
Nordihydroguaiaretic acid Aedes aegypti 6.7     0.005% (w/v) N 3749035
Nordihydroguaiaretic acid Aedes aegypti 13.6     0.01% (w/v) N 3749035
Nordihydroguaiaretic acid Aedes aegypti 64.3     0.005% (w/v) Y 3749035
Curare Asplanchna brightwelli -24     0.00% Y 3833547
Curare Asplanchna brightwelli 26     0.00% Y 3833547
Curare Asplanchna brightwelli 32     0.00% Y 3833547
Nordihydroguaiaretic acid Aedes aegypti 11.9     0.001% (w/v) N 3749035
Ethoxyquin Mus musculus 18.1   C3H 0.5% w/w Y 4927196
Curare Asplanchna brightwelli 34     0.00% Y 3833547
Vitamin E Asplanchna brightwelli 21     25 µg/mL Y 6479253
Ethoxyquin Mus musculus 19.9   C3H 0.5% w/w Y 4927196
Thyroxin Rattus norvegicus -3.5   Wistar 0.5 µg/g bodyweight ND 6632988
Thyroxin Rattus norvegicus 6.9   Wistar 0.5 µg/g bodyweight ND 6632988
Thyroxin Rattus norvegicus 8.4   Wistar 1 µg/g bodyweight ND 6632988
Thyroxin Rattus norvegicus 11.6   Wistar 2 µg/g bodyweight ND 6632988
Thyroxin Rattus norvegicus 11.1   Wistar 2 µg/g bodyweight ND 6632988
Butylated hydroxytoluene Drosophila bipectinata 13     100 µM Y 6656301
Thyroxin Rattus norvegicus 16.1   Wistar 1 µg/g bodyweight ND 6632988
Butylated hydroxytoluene Drosophila bipectinata 4.3     10 µM Y 6656301
Butylated hydroxytoluene Drosophila bipectinata 14.3     100 µM Y 6656301
Butylated hydroxytoluene Drosophila bipectinata 26.1     1000 µM Y 6656301
Butylated hydroxytoluene Drosophila bipectinata 4.8     10 µM Y 6656301
Thiazolidine carboxylic acid Drosophila melanogaster 31   Oregon R 0.3% wt/vol Y 6821144
Butylated hydroxytoluene Drosophila bipectinata 19     1000 µM Y 6656301
Vitamin E Drosophila melanogaster 14   Oregon R 0.4% wt/vol Y 6821144
Sodium borate Drosophila melanogaster -69.2   Oregon R 0.01 M Y 7889879
Sodium borate Drosophila melanogaster -51.9   Oregon R 0.05 M Y 7889879
Sodium borate Drosophila melanogaster 0   Oregon R 1 µM N 7889879
Sodium borate Drosophila melanogaster 1.5   Oregon R 0.01 mM Y 7889879
Sodium borate Drosophila melanogaster 3   Oregon R 0.1 mM Y 7889879
Sodium borate Drosophila melanogaster 9.5   Oregon R 0.25 mM N 7889879
Sodium borate Drosophila melanogaster -21.2   Oregon R 1 mM Y 7889879
Sodium borate Mus musculus 0.8   C57BL/6J 0.5 mM (21.6 ppm) N 7889879
Black tea extract Drosophila melanogaster 20.2   Oregon R Instead of water Y 8326745
Melatonin Mus musculus 18.1   BALB/c 10 micro-g/ml of water Y 8290600
Caffeine Drosophila melanogaster -10.1   Oregon R 0.01 mg/ml N 8326745
Caffeine Drosophila melanogaster -3.3   Oregon R 1 mg/ml N 8326745
Sodium borate Mus musculus -2.9   C57BL/6J 0.1 mM (4.3 ppm) N 7889879
Catechin Drosophila melanogaster -8.5   Oregon R 0.1 mg/ml N 8326745
Caffeine Drosophila melanogaster 1.7   Oregon R 0.1 mg/ml N 8326745
Catechin Drosophila melanogaster -5.1   Oregon R 1 mg/ml N 8326745
Epicatechin Drosophila melanogaster 1.8   Oregon R 0.01 mg/ml N 8326745
Epicatechin Drosophila melanogaster 3.7   Oregon R 0.1 mg/ml N 8326745
Catechin Drosophila melanogaster -5.1   Oregon R 0.01 mg/ml N 8326745
Epicatechin Drosophila melanogaster 7.4   Oregon R 1 mg/ml N 8326745
Tannic acid Drosophila melanogaster 0   Oregon R 1 mg/ml N 8326745
Green tea extract Drosophila melanogaster 8.6   Oregon R Instead of water Y 8326745
Tannic acid Drosophila melanogaster 0   Oregon R 0.1 mg/ml N 8326745
Tannic acid Drosophila melanogaster -2.9   Oregon R 1 mg/ml N 8326745
Tea (Camellia sinensis) extract Drosophila melanogaster 15.7   Oregon R Instead of water Y 8326745
Tea (Camellia sinensis) extract Drosophila melanogaster 7   Oregon R 1:10 dilution Y 8326745
Tea (Camellia sinensis) extract Drosophila melanogaster 20.2   Oregon R Instead of water Y 8326745
L-deprenyl Rattus norvegicus 15.1   F344/DuCrj 0.5 mg/kg. 3 times a week Y 8423709
Tea (Camellia sinensis) extract Drosophila melanogaster 12.2   Oregon R Instead of water Y 8326745
L-deprenyl Canis lupus familiaris     Beagles 1 mg/kg ND 9307048
Ginkgo biloba extract Rattus norvegicus 17.4   Fischer 344 50 mg/kg Y 9469738
Epithalamin Mus musculus 31   C3H/Sn NA Y 9701766
Epithalamin Drosophila melanogaster 16     NA Y 9701766
Melatonin Drosophila melanogaster 5.5   Canton S 0.08% per unit mass culture medium Y 10100152
Melatonin Drosophila melanogaster 4.8   Canton S 0.08% per unit mass culture medium Y 10100152
Epithalamin Rattus norvegicus 25     NA Y 9701766
Tocotrienol Caenorhabditis elegans 8.7   N2 8 µg/ml Y 10843344
Tocotrienol Caenorhabditis elegans 19.8   N2 80 µg/ml Y 10843344
EUK-134 Caenorhabditis elegans 29   N2 0.05 mM Y 10968795
EUK-134 Caenorhabditis elegans 38   N2 0.5 mM Y 10968795
EUK-134 Caenorhabditis elegans 52   N2 5 mM Y 10968795
EUK-134 Caenorhabditis elegans 42   N2 5 mM Y 10968795
EUK-134 Caenorhabditis elegans 38   N2 0.05 mM Y 10968795
EUK-134 Caenorhabditis elegans 52   N2 10 mM Y 10968795
EUK-134 Caenorhabditis elegans 54   N2 0.5 mM Y 10968795
Vitamin E Caenorhabditis elegans 2.9   N2 80 ug/ml Y 10843344
EUK-8 Caenorhabditis elegans 29   N2 10 mM Y 10968795
EUK-8 Caenorhabditis elegans 33   N2 0.05 mM Y 10968795
EUK-8 Caenorhabditis elegans 29   N2 5 mM Y 10968795
EUK-8 Caenorhabditis elegans 38   N2 0.5 mM Y 10968795
Epitalon Drosophila melanogaster 3.2   Canton S 5*10^-6 % N 11087911
Epitalon Drosophila melanogaster 7.1   Canton S 1*10^-9 % N 11087911
Epitalon Drosophila melanogaster 3.2   Canton S 1*10^-6 % N 11087911
EUK-8 Caenorhabditis elegans 33   N2 5 mM Y 10968795
Epitalon Drosophila melanogaster 10.8   Canton S 1*10^-7 % Y 11087911
Epitalon Drosophila melanogaster 11.3   Canton S 5*10^-6 % Y 11087911
Epitalon Drosophila melanogaster 11.8   Canton S 1*10^-7 % Y 11087911
Epitalon Drosophila melanogaster 12.8   Canton S 1*10^-6 % Y 11087911
Epitalon Drosophila melanogaster 13.4   Canton S 1*10^-8 % Y 11087911
Epitalon Drosophila melanogaster 12   Canton S 1*10^-8 % Y 11087911
Epitalon Drosophila melanogaster 16.6   Canton S 1*10^-9 % Y 11087911
D-glucosamine Saccharomyces cerevisiae 0   W303R 0.5 mg/ml N 11805047
D-glycerol Saccharomyces cerevisiae 49.8   PSY316 1 M ND 12391171
D-xylitol Saccharomyces cerevisiae 36.8   PSY316 1 M ND 12391171
Glucose Saccharomyces cerevisiae 19.8   PSY316 10% ND 12391171
Glucose Saccharomyces cerevisiae 63.1   PSY316 20% ND 12391171
Carnosine Drosophila melanogaster 24.3   D-32 200 mg/l Y 12447464
Sorbitol Saccharomyces cerevisiae 29.9   PSY316 1 M ND 12391171
Carnosine Drosophila melanogaster 19.5   D-32 0.2 mg/l Y 12447464
Carnosine Drosophila melanogaster 26.4   D-32 2 mg/l Y 12447464
EUK-8 Caenorhabditis elegans -83.9   N2 5 mM Y 12521609
EUK-8 Caenorhabditis elegans -83.7   N2 5 mM Y 12521609
EUK-8 Caenorhabditis elegans -81   N2 5 mM Y 12521609
EUK-8 Caenorhabditis elegans -26.5   N2 0.5 mM Y 12521609
EUK-8 Caenorhabditis elegans -33.1   N2 0.5 mM Y 12521609
EUK-8 Caenorhabditis elegans -26.6   N2 0.5 mM Y 12521609
EUK-8 Caenorhabditis elegans -21.1   N2 0.5 mM Y 12521609
EUK-8 Caenorhabditis elegans -12.9   N2 0.05 mM Y 12521609
EUK-8 Caenorhabditis elegans -10.7   N2 0.5 mM Y 12521609
EUK-8 Caenorhabditis elegans -6.1   N2 0.05 mM Y 12521609
Carnosine Drosophila melanogaster     D-32 200 mg/l N 12447464
EUK-8 Caenorhabditis elegans -5.7   N2 0.05 mM N 12521609
EUK-8 Caenorhabditis elegans -0.9   N2 0.05 mM N 12521609
EUK-8 Caenorhabditis elegans -0.9   N2 0.05 mM N 12521609
Butein Saccharomyces cerevisiae 31   PSY316AT MATα 10 µM Y 12939617
EUK-8 Caenorhabditis elegans 3   N2 0.05 mM N 12521609
Resveratrol Saccharomyces cerevisiae 60.7   PSY316AT MATα 10 µM Y 12939617
Fisetin Saccharomyces cerevisiae 55   PSY316AT MATα 10 µM Y 12939617
Resveratrol Saccharomyces cerevisiae 40   PSY316AT MATα 100 µM Y 12939617
Resveratrol Saccharomyces cerevisiae 39.5   PSY316AT MATα 500 µM Y 12939617
Resveratrol Saccharomyces cerevisiae 70   PSY316AT MATα 10 µM Y 12939617
Royal Jelly Mus musculus 23.6   C3H/HeJ 500 ppm ad libitum in diet Y 12954483
Coenzyme Q10 Caenorhabditis elegans 6   N2 50 µg/ml Y 14706236
Vitamin E Caenorhabditis elegans 11   N2 400 µg/ml Y 14706236
Coenzyme Q10 Caenorhabditis elegans 18   N2 150 µg/ml Y 14706236
Coenzyme Q10 Caenorhabditis elegans 9   N2 150 µg/ml Y 14706236
Tetrahydrocurcumin Mus musculus 10.6   Sprague-Dawley 0.002 Y 15247057
Green tea polyphenols Mus musculus 6.4   Sprague-Dawley 80 mg/L Y 15247057
Fisetin Drosophila melanogaster 23   Canton S 100 µm Y 15254550
Resveratrol Caenorhabditis elegans 10   N2 100 µm Y 15254550
Resveratrol Drosophila melanogaster 16   Canton S 100 µm Y 15254550
Resveratrol Drosophila melanogaster 20   Canton S 100 µm Y 15254550
Vitamin E Asplanchna brightwelli 24.5   clone 4B61 3 mM Y 15374519
3,3'-thiodipropionic acid Asplanchna brightwelli 16.4   clone 4B61 2 mM Y 15374519
Resveratrol Saccharomyces cerevisiae 0   BY4741 100 mg/ml N 15684413
Resveratrol Saccharomyces cerevisiae 0   PSY316 100 mg/ml N 15684413
Trichostatin A Drosophila melanogaster 15.6   Canton S 10 µmol/L ND 15695762
Resveratrol Saccharomyces cerevisiae 0   W303R 100 mg/ml N 15684413
Resveratrol Caenorhabditis elegans 14   N2 0.5 mM Y 16256736
Resveratrol Caenorhabditis elegans 17.8   N2 1 mM Y 16256736
Dauer-inducing Pheromone Caenorhabditis elegans 13.3   N2 5% in food ND 16377915
Dauer-inducing Pheromone Caenorhabditis elegans 26.7   N2 10% in food ND 16377915
Resveratrol Caenorhabditis elegans 9.3   N2 0.1 mM Y 16256736
Crude BB extract (Vaccinium angustifolium) Caenorhabditis elegans 37   fem-1(hc17) 1.5 mg/mL Y 16441844
Ampicillin Caenorhabditis elegans 34   fem-1(hc17) 100 µg/ml Y 16441844
L-deprenyl Rattus norvegicus 8.1   F344/DuCrj 0.25 mg/kg. 3 times a week Y 16463106
Tamarixetin Caenorhabditis elegans 28     NA ND 16872777
L-deprenyl Rattus norvegicus 6.7   F344/DuCrj 0.25 mg/kg. 3 times a week Y 16463106
3,5-dihydroxy-4'-acetoxy-trans-stilbene Saccharomyces cerevisiae 68.2   PSY316ATα 10 µM Y 17156081
Tocotrienol Caenorhabditis elegans 20   N2 NA ND 16872777
3,5-dihydroxy-4'-thiomethyl-trans-stilbene Saccharomyces cerevisiae 22.7   PSY316ATα 10 µM Y 17156081
3,5-dihydroxy-4'-ethyl-trans-stilbene Saccharomyces cerevisiae 51.5   PSY316ATα 10 µM Y 17156081
Resveratrol Saccharomyces cerevisiae 41.6   PSY316ATα 10 µM Y 17156081
Ginkgo biloba extract Caenorhabditis elegans 8   N2 100 µg/ml ND 16872777
Resveratrol Saccharomyces cerevisiae 33.9   PSY316ATα 10 µM Y 17156081
Gamma-tocopherol Caenorhabditis elegans 17   fem-1(hc17) 20 µg/ml Y 17169403
Gamma-tocopherol Caenorhabditis elegans 21   fem-1(hc17) 200 µg/ml Y 17169403
Pregnenolone Caenorhabditis elegans 20   N2 60 µg/mL Y 17266678
Vitamin E Drosophila melanogaster 2   Canton S 100 µg/ml Y 17169403
Nicotinamide riboside Saccharomyces cerevisiae 20   BY4741 10 µM N 17482543
Resveratrol Caenorhabditis elegans 7.4   N2 100 µM Y 17875315
Resveratrol Caenorhabditis elegans 8.1   N2 100 µM N 17875315
Resveratrol Caenorhabditis elegans 7.5   N2 100 µM Y 17875315
Resveratrol Caenorhabditis elegans 3.4   N2 100 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 10 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 1 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 32 µM Y 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 100 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 200 µM N 17875315
Resveratrol Drosophila melanogaster 3.4   Canton S 1000 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 1 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 3.2 µM N 17875315
Resveratrol Drosophila melanogaster -7.7   Canton S 10 µM Y 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 100 µM N 17875315
Resveratrol Drosophila melanogaster -15.4   Canton S 32 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 200 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Canton S 1000 µM N 17875315
Resveratrol Drosophila melanogaster -8.3   Canton S 10 µM Y 17875315
Resveratrol Drosophila melanogaster 2.8   Canton S 1 µM N 17875315
Resveratrol Drosophila melanogaster -13.9   Canton S 32 µM Y 17875315
Resveratrol Drosophila melanogaster -2.8   Canton S 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 2.8   Canton S 100 µM N 17875315
Resveratrol Drosophila melanogaster -6.8   Canton S 1 µM N 17875315
Resveratrol Drosophila melanogaster -8.3   Canton S 1000 µM N 17875315
Resveratrol Drosophila melanogaster 4.5   Canton S 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 200 µM N 17875315
Resveratrol Drosophila melanogaster -4.5   Canton S 10 µM N 17875315
Resveratrol Drosophila melanogaster 9.1   Canton S 32 µM N 17875315
Resveratrol Drosophila melanogaster -4.5   Canton S 200 µM N 17875315
Resveratrol Drosophila melanogaster 4.5   Canton S 1000 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 100 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 10 µM N 17875315
Resveratrol Drosophila melanogaster 8.2   Canton S 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 100 µM N 17875315
Resveratrol Drosophila melanogaster -2   Canton S 32 µM N 17875315
Resveratrol Drosophila melanogaster 2   Canton S 200 µM N 17875315
Resveratrol Drosophila melanogaster -2   Canton S 1000 µM N 17875315
Resveratrol Drosophila melanogaster -2.8   Dahomey 3.2 µM N 17875315
Resveratrol Drosophila melanogaster -5.6   Dahomey 1 µM N 17875315
Resveratrol Drosophila melanogaster 0   Canton S 1 µM N 17875315
Resveratrol Drosophila melanogaster -5.6   Dahomey 10 µM Y 17875315
Resveratrol Drosophila melanogaster -2.8   Dahomey 32 µM N 17875315
Resveratrol Drosophila melanogaster -2.8   Dahomey 200 µM N 17875315
Resveratrol Drosophila melanogaster 6.9   Dahomey 1 µM N 17875315
Resveratrol Drosophila melanogaster 2.8   Dahomey 100 µM N 17875315
Resveratrol Drosophila melanogaster -5.6   Dahomey 1000 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Dahomey 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 3.4   Dahomey 10 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Dahomey 100 µM N 17875315
Resveratrol Drosophila melanogaster -3.7   Dahomey 1 µM N 17875315
Resveratrol Drosophila melanogaster -3.4   Dahomey 32 µM N 17875315
Resveratrol Drosophila melanogaster 6.9   Dahomey 1000 µM N 17875315
Resveratrol Drosophila melanogaster 0   Dahomey 200 µM N 17875315
Resveratrol Drosophila melanogaster -7.4   Dahomey 3.2 µM N 17875315
Resveratrol Drosophila melanogaster -7.4   Dahomey 32 µM N 17875315
Resveratrol Drosophila melanogaster 0   Dahomey 10 µM N 17875315
Resveratrol Drosophila melanogaster -3.7   Dahomey 100 µM N 17875315
Resveratrol Drosophila melanogaster -7.4   Dahomey 1000 µM N 17875315
Resveratrol Drosophila melanogaster -3   Dahomey 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 15.2   Dahomey 10 µM N 17875315
Resveratrol Drosophila melanogaster -7.4   Dahomey 200 µM N 17875315
Resveratrol Drosophila melanogaster 9.1   Dahomey 32 µM N 17875315
Resveratrol Drosophila melanogaster 0   Dahomey 100 µM N 17875315
Resveratrol Drosophila melanogaster 12.1   Dahomey 200 µM N 17875315
Resveratrol Drosophila melanogaster 3   Dahomey 1000 µM N 17875315
Resveratrol Drosophila melanogaster 2.8   Dahomey 3.2 µM N 17875315
Resveratrol Drosophila melanogaster 1.4   Dahomey 1 µM N 17875315
Resveratrol Drosophila melanogaster 15.2   Dahomey 1 µM N 17875315
Resveratrol Drosophila melanogaster -1.4   Dahomey 100 µM Y 17875315
Resveratrol Drosophila melanogaster 0   Dahomey 32 µM N 17875315
Resveratrol Drosophila melanogaster -1.4   Dahomey 200 µM Y 17875315
Resveratrol Drosophila melanogaster -2.8   Dahomey 1000 µM N 17875315
Resveratrol Drosophila melanogaster 0   Dahomey 10 µM N 17875315
Rhodiola rosea Drosophila melanogaster 11.9     30 mg/mL Y 17990971
Lithium Chloride Caenorhabditis elegans 36   N2 10 mM Y 17959600
Rhodiola rosea Drosophila melanogaster 14     30 mg/mL Y 17990971
Mianserin Caenorhabditis elegans 31   N2 50 µM Y 18033297
Hydrogen Sulphide Caenorhabditis elegans 74   N2 50 ppm Y 18077331
Acticoa powder Rattus norvegicus 11   Wistar-Unilever 24 mg/5 ml/kg Y 18179729
Vitamin E Mus musculus 15   C57BL/6J 550 mg/kg Y 18257658
Platinum nanoparticles Caenorhabditis elegans 22   N2 0.5 mM Y 18400258
Caffeine Saccharomyces cerevisiae 86   BY4741 0.2-0.4 mM Y 18513215
Reserpine Caenorhabditis elegans 31   N2 30 µM Y 18409080
Eleutherococcus senticosus root extract Caenorhabditis elegans 16   N2 250 µg/ml Y 18536978
Rhodiola rosea root extract Caenorhabditis elegans 15   N2 10 µg/ml Y 18536978
Nordihydroguaiaretic acid Mus musculus 12   UM-HET3 2.5 g/kg food Y 18631321
Quercetin Caenorhabditis elegans 10   N2 100 µM Y 18692520
2,4-dinitrophenol Mus musculus 7.1   Swiss Webster 1 mg/L Y 18505478
Alpha-lipoic acid Rattus norvegicus 0   BN/SsNOlaHSD 1.5 g/kg N 18486188
Quercetin Caenorhabditis elegans 10   N2 200 µM Y 18692520
Trolox Caenorhabditis elegans 31   N2 3 mM Y 18755260
Taxifolin Caenorhabditis elegans 51   N2 820 µM Y 18755260
Quercetin Caenorhabditis elegans 9   N2 200 µM Y 19043800
Quercetin Caenorhabditis elegans 10   N2 200 µM Y 19043800
Epigallocatechin-3-gallate Caenorhabditis elegans 12.2   N2 NA Y 19085685
Cocoa Drosophila melanogaster     rosy^+5 100 g/l medium N 19083435
SkQ1 Drosophila melanogaster 14     20 pM-20 nM Y 19120018
SkQ1 Ceriodaphnia affinis 100     0.55 nM Y 19120018
Cocoa Drosophila melanogaster     rosy^+5 50 g/l medium Y 19083435
SkQ1 Podospora anserina 50     100 nM Y 19120018
Lamotrigine Drosophila melanogaster 17.2   Ives 12 mg/ml Y 19430925
Coenzyme Q10 Caenorhabditis elegans 19   clk-1 (qm30)   Y 19428456
Nicotinamide adenine dinucleotide Caenorhabditis elegans 15   N2 100 µM ND 19370397
Lamotrigine Drosophila melanogaster 15.4   Ives 12 mg/ml Y 19430925
Carbonylcyanide-3-chlorophenylhydrazone Caenorhabditis elegans 60   N2 10 µM Y 19442682
Catechin Caenorhabditis elegans 13   N2 200 µm Y 19501612
Juglone Caenorhabditis elegans 29   N2 40 µm Y 19597959
Black tea extract Drosophila melanogaster 10     10 mg/ml Y 19770032
Spermidine Drosophila melanogaster 30   w1118 1 mM Y 19801973
Spermidine Saccharomyces cerevisiae 233     4 mM Y 19801973
Acetic Acid Caenorhabditis elegans 23   N2 50 ppm Y 19837596
Reishi polysaccharide Caenorhabditis elegans 35   N2 100 ppm Y 19837596
Glucose Caenorhabditis elegans -19   N2 2% Y 19883616
Glucose Caenorhabditis elegans -19   N2 2% Y 19883616
Spermidine Caenorhabditis elegans 15   N2 0.2 mM Y 19801973
Glucose Caenorhabditis elegans -11   N2 2% Y 19883616
Glucose Caenorhabditis elegans 0   N2 2% N 19883616
Glucose Caenorhabditis elegans 11   N2 2% N 19883616
Glucose Caenorhabditis elegans -9   N2 2% Y 19883616
Glucose Caenorhabditis elegans -24   N2 2% Y 19883616
Glucose Caenorhabditis elegans -15   N2 2% Y 19883616
Glucose Caenorhabditis elegans -20   N2 2% Y 19883616
Glucose Caenorhabditis elegans -31   N2 2% Y 19883616
Glucose Caenorhabditis elegans -15   N2 2% Y 19883616
Glucose Caenorhabditis elegans -17   N2 2% Y 19883616
Glucose Caenorhabditis elegans -28   N2 2% Y 19883616
Glucose Caenorhabditis elegans -23   N2 2% Y 19883616
Glucose Caenorhabditis elegans -16   N2 2% Y 19883616
Glucose Caenorhabditis elegans -17   N2 102% Y 19883616
Glycerol Caenorhabditis elegans -36   N2 1% Y 19883616
Glycerol Caenorhabditis elegans -23   N2 1% Y 19883616
Sorbitol Caenorhabditis elegans 5   N2 2% N 19883616
Glycerol Caenorhabditis elegans -24   N2 1% Y 19883616
Rapamycin Mus musculus     C57BL/6J 4 mg/kg Y 19934433
Sorbitol Caenorhabditis elegans -2   N2 2% N 19883616
Rapamycin Drosophila melanogaster 13   white Dahomey 200 µM Y 20074526
SQDB Caenorhabditis elegans 12   N2 100 µg/ml Y 20179756
VI-28 Mus musculus 7.2   C57BL/6J 0.005 N 20370440
VI-28 Mus musculus 8.8   C57BL/6J 0.0005 Y 20370440
VI-28 Mus musculus 13.5   C57BL/6J 0.005 Y 20370440
VI-28 Mus musculus 14.4   C57BL/6J 0.0005 Y 20370440
Tannic acid Caenorhabditis elegans 18   N2 100 µM Y 20413530
Indolepropionamide Philodina acuticornis 137.8   odiosa 10 µM Y 20421998
Indolepropionamide Philodina acuticornis 229.7   odiosa 20 µM Y 20421998
Phaseolus vulgaris Extract Caenorhabditis elegans 13.2   N2 150 µg / mL Y 20455573
Indolepropionamide Philodina acuticornis 267.9   odiosa 30 µM Y 20421998
Trehalose Caenorhabditis elegans 32   N2 5 mM Y 20477758
DhHP-6 Caenorhabditis elegans 21   N2 200 µM Y 20528576
L-Carnitine Saccharomyces cerevisiae 140   BY4741 1 mM N 20550520
L-Carnitine Saccharomyces cerevisiae 260   BY4741 1 mM N 20550520
L-Carnitine Saccharomyces cerevisiae 50   CM39L-11A 1 mM N 20550520
L-Carnitine Saccharomyces cerevisiae 42.8   CM39L-11A 1 mM N 20550520
Curcumin Drosophila melanogaster 19   Canton S 100 µM Y 20645870
Lithocholic acid Saccharomyces cerevisiae 100   BY4741 50 µM Y 20622262
Carnosine Drosophila melanogaster 20     50 mg/l Y 20681748
L-Carnitine Saccharomyces cerevisiae 62.4   CM39L-11A 1 mM N 20550520
S,S-trolox-carnosine Drosophila melanogaster 16     50 mg/L Y 20681748
L-Carnitine Saccharomyces cerevisiae 21.4   CM39L-11A 1 mM N 20550520
S,S-trolox-carnosine Drosophila melanogaster 36     50 mg/L Y 20681748
Curcumin Drosophila melanogaster 18   Ives 250 µM Y 20645870
Apple polyphenols Caenorhabditis elegans 12   N2 100 µg/ml Y 20717869
Procyanidins Caenorhabditis elegans 12.1   N2 65 µg/ml Y 20717869
Sodium pyruvate Caenorhabditis elegans 13.9   N2 2.5 mM Y 21040400
Morphine Drosophila melanogaster 3.2   Oregon R   Y 21061062
Morphine Drosophila melanogaster 2.6   Oregon R   Y 21061062
Celecoxib Caenorhabditis elegans 19   N2 10 µM Y 21348927
Apple polyphenols Drosophila melanogaster 10   Oregon R NA Y 21319854
Pyrrolidine dithiocarbamate Drosophila melanogaster 16     20 mg/l Y 21483034
Oregano and Cranberry extracts Anastrepha ludens 43   Loew 0.02 Y 21455602
Diallyl trisulfide Caenorhabditis elegans 13   TJ1060 10 µM Y 21296648
Pyrrolidine dithiocarbamate Drosophila melanogaster 15     20 mg/l Y 21483034
Caffeic acid Caenorhabditis elegans 11   N2 300 µM Y 21503726
Q3M Caenorhabditis elegans 20   N2 20 µg/mL Y 21563825
Q3'G Caenorhabditis elegans 12   N2 21 µg/mL Y 21563825
Electrolyzed reduced water Caenorhabditis elegans 12.1   N2   Y 21737933
Rosmarinic acid Caenorhabditis elegans 10   N2 200 µM Y 21503726
Electrolyzed reduced water Caenorhabditis elegans 15.5   N2   Y 21737933
Electrolyzed reduced water Caenorhabditis elegans 32.3   N2   Y 21737933
Epicatechin Drosophila melanogaster 42   Canton S 0.1 mM/l Y 21525262
Electrolyzed reduced water Caenorhabditis elegans 37.4   N2   Y 21737933
Platinum nanoparticles Caenorhabditis elegans 1.7   N2 50 ppb N 21737933
Quercetin Caenorhabditis elegans 14   N2 22 µg/mL Y 21563825
Platinum nanoparticles Caenorhabditis elegans 3.9   N2 2 ppb N 21737933
Platinum nanoparticles Caenorhabditis elegans 5   N2 10 ppb N 21737933
Platinum nanoparticles Caenorhabditis elegans 7.1   N2 5 ppb Y 21737933
Ferulsinaic acid Caenorhabditis elegans 20   N2 100 µM Y 21749391
Platinum nanoparticles Caenorhabditis elegans 18.2   N2 2 ppb Y 21737933
Plumbagin Caenorhabditis elegans -23   N2 150 µM Y 21765926
Plumbagin Caenorhabditis elegans -84   N2 200 µM Y 21765926
Plumbagin Caenorhabditis elegans -91   N2 250 µM Y 21765926
Plumbagin Caenorhabditis elegans -86   N2 250 µM Y 21765926
Plumbagin Caenorhabditis elegans -86   N2 300 µM Y 21765926
Plumbagin Caenorhabditis elegans -90   N2 400 µM Y 21765926
Plumbagin Caenorhabditis elegans -81   N2 500 µM Y 21765926
Plumbagin Caenorhabditis elegans -91   N2 500 µM Y 21765926
Gallic Acid Caenorhabditis elegans 10   N2 300 µM Y 21805983
Rasayana Drosophila melanogaster 51.1   Oregon-K 1 drop Y 21836798
Rasayana Drosophila melanogaster 55   Oregon-K 1 drop Y 21836798
Curcumin Caenorhabditis elegans 39   N2 20 µM Y 21855561
Spermine Mus musculus     Crj:CD-1 3 mg.kg-1.dose-1 Y 21858192
Astragalus membranaceus polysaccharide Caenorhabditis elegans 23.8   N2 1-2.5 mg/ml Y 21892924
Dafadine-A Caenorhabditis elegans 29   N2 50 µM Y 22057127
Resveratrol Drosophila melanogaster -2.1   Canton S 200 µM N 22083438
Resveratrol Drosophila melanogaster 1   Canton S 100 µM N 22083438
Resveratrol Drosophila melanogaster -1.5   Canton S 200 µM N 22083438
Blueberry extract Drosophila melanogaster 10     5 mg/ml Y 22197903
Reserpine Caenorhabditis elegans 30   N2 60 uM Y 22212533
Icariin Caenorhabditis elegans 20.7   N2 45 µM Y 22216122
Resveratrol Drosophila melanogaster 1.8   Canton S 100 µM N 22083438
Minocycline Drosophila melanogaster 49   Oregon 0.05 mM Y 22330257
Erbstatin analog Drosophila melanogaster 18   Oregon R 5 mM Y 22363408
AG-490 Drosophila melanogaster 17.5   Oregon R 300 µM Y 22363408
Everolimus Drosophila melanogaster 16.6   Oregon R 3 mM Y 22363408
HA-1004 Drosophila melanogaster 18   Oregon R 1-10 µM Y 22363408
HA-1077 Drosophila melanogaster 14.5   Oregon R 10 µM Y 22363408
Indirubin Drosophila melanogaster 8.2   Oregon R 3 mM Y 22363408
PD-98059 Drosophila melanogaster 27   Oregon R 300-1000 µM Y 22363408
PP2 AG1879 Drosophila melanogaster 22.8   Oregon R 300 µM Y 22363408
Quercetin dihydrate Drosophila melanogaster 23   Oregon R 1 mM Y 22363408
KN-93 Drosophila melanogaster 20   Oregon R 10-100 µM Y 22363408
SB203580 Drosophila melanogaster 30.3   Oregon R 300 µM Y 22363408
SP600125 Drosophila melanogaster 23.5   Oregon R 10 mM Y 22363408
Tyrphostin 1 Drosophila melanogaster 19   Oregon R 100-300 µM Y 22363408
Tyrphostin 9 Drosophila melanogaster 17.3   Oregon R 300-500 µM Y 22363408
Polyphenols Mus musculus 6.3   C57BL/6J alternate no food/high-fat chow Y 22265987
Tyrphostin AG 1295 Drosophila melanogaster 22.5   Oregon R 300-500 µM Y 22363408
Tyrphostin AG 1478 Drosophila melanogaster 19.5   Oregon R 100 µM Y 22363408
Damnacanthus officinarum leaf extract Caenorhabditis elegans 18.6   N2 1200 µg/mL Y 22370553
Damnacanthus officinarum root extract Caenorhabditis elegans 30.3   N2 1200 µg/mL Y 22370553
Staurosporine Drosophila melanogaster 34.8   Oregon R 30-50 µM Y 22363408
Curcumin Mus musculus 4.5   UM-HET3 2000 mg/kg of food N 22451473
Curcumin Mus musculus 2.8   UM-HET3 2000 mg/kg of food N 22451473
Green tea extract Mus musculus 6.6   UM-HET3 2000 mg/kg of food N 22451473
Medium-chain triglyceride oil Mus musculus -1.1   UM-HET3 60000 mg/kg of diet N 22451473
Medium-chain triglyceride oil Mus musculus 1.8   UM-HET3 60000 mg/kg of diet N 22451473
Resveratrol Mus musculus 3.4   UM-HET3 300 mg/kg of food N 22451473
Oxaloacetate Mus musculus 2.7   UM-HET3 2200 mg/Kg of food N 22451473
Oxaloacetate Mus musculus 4.2   UM-HET3 2200 mg/Kg of food N 22451473
Proline Caenorhabditis elegans 5.8   N2 5 µM Y 22482728
Resveratrol Mus musculus 4.7   UM-HET3 300 mg/kg of food N 22451473
Hesperidin Saccharomyces cerevisiae 15.4   BY4741 5 µM Y 22484922
Hesperidin Saccharomyces cerevisiae 36.9   BY4741 10 µM Y 22484922
Hesperidin Saccharomyces cerevisiae 4.6   BY4741 50 µM Y 22484922
Green tea extract Mus musculus 4.6   UM-HET3 2000 mg/kg of food N 22451473
Resveratrol Saccharomyces cerevisiae 33.8   BY4741 10 µM Y 22484922
Quercetin Caenorhabditis elegans -7   N2 250 µM Y 22493606
Quercetin Caenorhabditis elegans 2   N2 50 µM N 22493606
Quercetin Caenorhabditis elegans 9   N2 200 µM Y 22493606
Quercetin Caenorhabditis elegans 11   N2 100 µM Y 22493606
Tannic acid Caenorhabditis elegans 1   N2 300 µM N 22493606
Tannic acid Caenorhabditis elegans 8   N2 200 µM Y 22493606
Tannic acid Caenorhabditis elegans -11   N2 400 µM Y 22493606
Tannic acid Caenorhabditis elegans 10   N2 25 µM Y 22493606
Quercetin Caenorhabditis elegans 10   N2 200 µM Y 22493606
Tannic acid Caenorhabditis elegans 18   N2 100 µM Y 22493606
Tannic acid Caenorhabditis elegans 19   N2 100 µM Y 22493606
Tannic acid Caenorhabditis elegans 16   N2 50 µM Y 22493606
Olive Oil Rattus norvegicus 18       Y 22498298
HF-HQ Caenorhabditis elegans 20   N2 400 µM Y 22529848
C60 Rattus norvegicus 90     1.7 mg/kg of body weight Y 22498298
HuminFeed Caenorhabditis elegans 12.5   N2 400 µM Y 22529848
Proanthocycanidin Caenorhabditis elegans 36.6   N2 67 µg/ml Y 22509764
Rapamycin Caenorhabditis elegans 19   N2 100 µM Y 22560223
1,2,4-triazolo[1,5-a]pyridine Caenorhabditis elegans 12   N2 500 nM Y 22509764
3,4-dihydroxybenzaldehyde Drosophila melanogaster 13   yw (y1w67c23) 0.3 mM Y 22809229
D-chiro-inositol Drosophila melanogaster 16.6   Canton S   Y 22843669
Simvastatin Drosophila melanogaster 25     240 µM Y 22737247
3,4-dihydroxybenzaldehyde Drosophila melanogaster 13   yw (y1w67c23) 3 mM Y 22809229
3,4-dihydroxybenzaldehyde Drosophila melanogaster 23   yw (y1w67c23) 1 mM Y 22809229
Pinitol Drosophila melanogaster 12.5   Canton S   Y 22843669
D-chiro-inositol Drosophila melanogaster 15   Canton S   Y 22843669
Cynomorium songaricum Rupr. Drosophila melanogaster 1.5   Canton S 10 mg/ml N 22844336
Cynomorium songaricum Rupr. Drosophila melanogaster 2.2   Canton S 20 mg/ml N 22844336
Pinitol Drosophila melanogaster 8.7   Canton S   Y 22843669
Cynomorium songaricum Rupr. Drosophila melanogaster 3.7   Canton S 30 mg/ml N 22844336
Salicylic acid Caenorhabditis elegans 13.9   N2 1 µM Y 22866967
Cynomorium songaricum Rupr. Drosophila melanogaster 17.6   Canton S 20 mg/ml Y 22844336
Aspirin Caenorhabditis elegans 23   N2 0.5 µM Y 22866967
Cynomorium songaricum Rupr. Drosophila melanogaster 15.3   Canton S 10 mg/ml Y 22844336
Cynomorium songaricum Rupr. Drosophila melanogaster 11.4   Canton S 30 mg/ml Y 22844336
Cranberry extract Caenorhabditis elegans 32.5   N2 2 mg/mL Y 22864793
Resveratrol Apis mellifera 38     30 µM Y 22868943
Black rice extract Drosophila melanogaster 14   Oregon R 30 mg/ml Y 22930061
Sevelamer Drosophila melanogaster 16   yw 1% Y 22942172
Aspirin Caenorhabditis elegans 20.9   N2 1 µM Y 22866967
Apple Saccharomyces cerevisiae 78.5   MCY4/KlLSM4::kanMX4 1 gr N 22970337
Apple flesh Saccharomyces cerevisiae 7   MCY4/KlLSM4::kanMX4 1 gr N 22970337
4-hydroxy-E-globularinin Caenorhabditis elegans 6.4   N2 200 µM Y 23000058
Apple peal Saccharomyces cerevisiae 28.5   MCY4/KlLSM4::kanMX4 1 gr N 22970337
4-hydroxy-E-globularinin Caenorhabditis elegans 8.1   N2 2 µM Y 23000058
Sodium butyrate Drosophila melanogaster -9.1   Ra 10 mM N 23044027
Sodium butyrate Drosophila melanogaster -10.9   Ra 100 mM Y 23044027
Sodium butyrate Drosophila melanogaster 4.2   Ra 100 mM Y 23044027
Sodium butyrate Drosophila melanogaster -6.3   Ra 100 mM N 23044027
4-hydroxy-E-globularinin Caenorhabditis elegans 18.8   N2 20 µM Y 23000058
Sodium butyrate Drosophila melanogaster -6.3   Ra 10 mM N 23044027
Sodium butyrate Drosophila melanogaster 8.3   Ra 100 mM Y 23044027
Sodium butyrate Drosophila melanogaster 8.3   Ra 10 mM Y 23044027
Sodium butyrate Drosophila melanogaster 12.5   Ra 10 mM Y 23044027
Curcumin Drosophila melanogaster -23.4   Ra 100 mM N 23063786
Curcumin Drosophila melanogaster -10.2   Ra 100 mM N 23063786
Curcumin Drosophila melanogaster     Ra 10 mM N 23063786
Curcumin Drosophila melanogaster     Ra 200 mM Y 23063786
Metformin Drosophila melanogaster -66   Dahomey 100 mM Y 23077661
Metformin Drosophila melanogaster -7   Dahomey 25 mM Y 23077661
Metformin Drosophila melanogaster -22   Dahomey 50 mM Y 23077661
Metformin Drosophila melanogaster -3   Dahomey 10 mM N 23077661
Metformin Drosophila melanogaster -6   Dahomey 50 mM N 23077661
Metformin Drosophila melanogaster 0   Dahomey 1 mM N 23077661
Metformin Drosophila melanogaster -6   Dahomey 10 mM N 23077661
Metformin Drosophila melanogaster -4   Dahomey 2.5 mM N 23077661
Metformin Drosophila melanogaster -31   Dahomey 100 mM Y 23077661
Metformin Drosophila melanogaster 0   Dahomey 5 mM N 23077661
Metformin Drosophila melanogaster 0   Dahomey 5 mM N 23077661
Metformin Drosophila melanogaster 4   Dahomey 1 mM N 23077661
Metformin Drosophila melanogaster -6   Dahomey 25 mM N 23077661
Metformin Drosophila melanogaster 7   Dahomey 5 mM N 23077661
Metformin Drosophila melanogaster 0   Dahomey 2.5 mM N 23077661
Sesame Drosophila melanogaster 12   Oregon R 2 mg/ml Y 23291977
Metoprolol Mus musculus 10   C3B6F1 1.1 g/kg diet Y 23314750
Nebivolol Mus musculus 6.4   C3B6F1 0.27 g/kg diet Y 23314750
DhHP-6 Caenorhabditis elegans 19.1   N2 100 µM Y 23410029
Omega-6 Caenorhabditis elegans 16   N2 10 µM Y 23392608
Nolinospiroside F Saccharomyces cerevisiae 21.3   K6001 10 µM Y 23439553
Nolinospiroside F Saccharomyces cerevisiae 19   K6001 1 µM Y 23439553
Nolinospiroside F Saccharomyces cerevisiae 22.6   K6001 3 µM Y 23439553
Resveratrol Saccharomyces cerevisiae 17.4   K6001 10 µM Y 23439553
Malate Caenorhabditis elegans 14   N2 10 mM Y 23472183
Aspirin Caenorhabditis elegans 16   N2 100 µM Y 23485446
Ascr#3 Caenorhabditis elegans 21   N2 400 nM Y 23509272
Huperzine A Caenorhabditis elegans 13.8   N2 300 µM Y 23523941
Fumarate Caenorhabditis elegans 16   N2 10 mM Y 23472183
Ascr#2 Caenorhabditis elegans 14   N2 400 nM Y 23509272
Fish oil Caenorhabditis elegans -12.8   N2 2 mg/plate Y 23526170
Fish oil Caenorhabditis elegans 8.9   N2 0.5 mg/plate N 23526170
Fish oil Caenorhabditis elegans 9.6   N2 1 mg/plate Y 23526170
Phenformin Caenorhabditis elegans 29   N2 4.5 mM Y 23540700
Platycladus orientalis seed extract Caenorhabditis elegans 26.5   N2 500 µg/ml Y 23523941
Arsenite Caenorhabditis elegans 10   N2 100 nM Y 23534459
Clofibrate Caenorhabditis elegans 16   N2 10 µM Y 23603800
Bezafibrate Caenorhabditis elegans 13   N2 10 µM Y 23603800
Curcumin Drosophila melanogaster 20.3   Wild 1-A 1 mg/g Y 23675008
Curcumin Drosophila melanogaster     Wild 1-A 0.5 mg/g N 23675008
Chloramphenicol Caenorhabditis elegans 15.8   N2 100 µg/ml Y 23698443
Rapamycin Mus musculus 4.8   C57BL/6 14 ppm Y 23682161
Fenofibrate Caenorhabditis elegans 19   N2 10 µM Y 23603800
Doxycycline Caenorhabditis elegans 36.48   N2 30 µg/ml Y 23698443
Doxycycline Caenorhabditis elegans 12.1   SJ4101 6 µg/ml Y 23698443
Doxycycline Caenorhabditis elegans 23.7   SJ4101 60 µg/ml Y 23698443
Doxycycline Caenorhabditis elegans 25.4   SJ4101 30 µg/ml Y 23698443
Doxycycline Caenorhabditis elegans 17.6   N2 6 µg/ml Y 23698443
Ethidium bromide Caenorhabditis elegans 30.1   N2 5 µg/ml Y 23698443
Resveratrol Caenorhabditis elegans 11.3   N2 100 µM Y 23698443
Rapamycin Caenorhabditis elegans 20.6   N2 1 nM Y 23698443
Rapamycin Caenorhabditis elegans 16.2   N2 1 nM Y 23698443
Myriocin Saccharomyces cerevisiae     BY4741 600 ng/ml ND 23725375
Rhodiola rosea root extract Drosophila melanogaster 36   w1118 NA Y 23704949
Rhodiola rosea root extract Drosophila melanogaster 40   w1118 NA Y 23704949
Myricetin Caenorhabditis elegans 32.9   N2 100 µM Y 23736695
Epigallocatechin-3-gallate Rattus norvegicus 13   Wistar 25 mg per kg per day Y 23834676
Myriocin Saccharomyces cerevisiae     DBY746 600 ng/ml ND 23725375
Rapamycin Mus musculus     C57BL/6J 14 mg/kg Y 23863708
Metformin Mus musculus 5.8   C57BL/6J 0.1% (w/w), 100 mg/kg diet Y 23900241
Minocycline Drosophila melanogaster 63   Oregon 0.05 mM ND 23947005
Lutein Drosophila melanogaster 11.4     0.1 mg/ml Y 23993264
Pyrrolidine dithiocarbamate Drosophila melanogaster 10   Canton S 125 µM Y 24096697
GYY4137 Caenorhabditis elegans 0.4   N2 100 µM N 24093496
Pyrrolidine dithiocarbamate Drosophila melanogaster 12   Canton S 125 µM Y 24096697
Wortmannin Drosophila melanogaster 5   Canton S 5 µM Y 24096697
Acanthophora spicifera extract Brachionus manjavacas 14     5 µg/ml Y 24120568
Jania acutilobum extract Brachionus manjavacas 9.1     5 µg/ml Y 24120568
Peyssonnelia sp. extract Brachionus manjavacas 8.5     2 µg/ml Y 24120568
Resveratrol Daphnia pulex clone TCO -6.5     0.3 µM N 24133070
Resveratrol Daphnia pulex clone TCO -32.3     3 µM Y 24133070
Resveratrol Daphnia pulex clone TCO 0     3 µM N 24133070
(R,R)-cis-Diethyl tetrahydro-2,8-chrysenediol Caenorhabditis elegans 7     33 µM Y 24134630
3,4-dichloroisocoumarin Caenorhabditis elegans 13     88 µM Y 24134630
AMN082 Caenorhabditis elegans 8     33 µM Y 24134630
4-phenyl-3-furoxancarbonitrile Caenorhabditis elegans 30     88 µM Y 24134630
7-cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine Caenorhabditis elegans 11     33 µM Y 24134630
Resveratrol Daphnia pulex clone TCO 0     0.3 µM N 24133070
Amperozide hydrochloride Caenorhabditis elegans 38     13 µM Y 24134630
Amoxapine Caenorhabditis elegans 33     88 µM Y 24134630
BRL 15572 Caenorhabditis elegans 10     33 µM Y 24134630
Beta-Estradiol Caenorhabditis elegans 7     33 µM Y 24134630
BRL 50481 Caenorhabditis elegans 18     176 µM Y 24134630
Chlorprothixene hydrochloride Caenorhabditis elegans 33     13 µM Y 24134630
Cis-(Z)-Flupenthixol dihydrochloride Caenorhabditis elegans 30     33 µM Y 24134630
Cinnarizine Caenorhabditis elegans 15     33 µM Y 24134630
Cortexolone maleate Caenorhabditis elegans 11     33 µM Y 24134630
BTCP hydrochloride Caenorhabditis elegans 14     88 µM Y 24134630
Cyclosporin A Caenorhabditis elegans 18     88 µM Y 24134630
Danazol Caenorhabditis elegans 13     33 µM Y 24134630
Cyproterone acetate Caenorhabditis elegans 23     33 µM Y 24134630
DAPH Caenorhabditis elegans 15     13 µM Y 24134630
Dihydroergotamine methanesulfonate Caenorhabditis elegans 24     88 µM Y 24134630
Demeclocycline hydrochloride Caenorhabditis elegans 16     33 µM Y 24134630
Dihydroergocristine methanesulfonate Caenorhabditis elegans 34     176 µM Y 24134630
Doxazosin mesylate Caenorhabditis elegans 15     33 µM Y 24134630
Doxycycline hydrochloride Caenorhabditis elegans 18     33 µM Y 24134630
Eliprodil Caenorhabditis elegans 16     88 µM Y 24134630
Guanfacine hydrochloride Caenorhabditis elegans 15     13 µM Y 24134630
Guanabenz acetate Caenorhabditis elegans 12     88 µM Y 24134630
Hexahydro-sila-diphenidol Caenorhabditis elegans 15     88 µM Y 24134630
Kenpaullone Caenorhabditis elegans 27     88 µM Y 24134630
Ketanserin tartrate Caenorhabditis elegans 13     176 µM Y 24134630
LFM-A13 Caenorhabditis elegans 27     88 µM Y 24134630
Loratadine Caenorhabditis elegans 18     33 µM Y 24134630
Loxapine succinate Caenorhabditis elegans 43     88 µM Y 24134630
LY-165,163 Caenorhabditis elegans 33     33 µM Y 24134630
LY-367,265 Caenorhabditis elegans 34     33 µM Y 24134630
Metergoline Caenorhabditis elegans 23     33 µM Y 24134630
Mianserin Caenorhabditis elegans 32     50 µM Y 24134630
Methylergonovine maleate Caenorhabditis elegans 28     88 µM Y 24134630
Minocycline hydrochloride Caenorhabditis elegans 29     88 µM Y 24134630
N-(2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide Caenorhabditis elegans 35     33 µM Y 24134630
Naftopidil dihydrochloride Caenorhabditis elegans 14     33 µM Y 24134630
Nortriptyline hydrochloride Caenorhabditis elegans 21     88 µM Y 24134630
Octoclothepin maleate Caenorhabditis elegans 38     13 µM Y 24134630
Oxatomide Caenorhabditis elegans 25     88 µM Y 24134630
Nicardipine hydrochloride Caenorhabditis elegans 23     176 µM Y 24134630
Promethazine hydrochloride Caenorhabditis elegans 32     176 µM Y 24134630
Pergolide methanesulfonate Caenorhabditis elegans 37     13 µM Y 24134630
Nitrendipine Caenorhabditis elegans 25     88 µM Y 24134630
Quinidine sulfate Caenorhabditis elegans 12     33 µM Y 24134630
Propionylpromazine hydrochloride Caenorhabditis elegans 20     33 µM Y 24134630
SU 4312 Caenorhabditis elegans 5     88 µM Y 24134630
Thioridazine hydrochloride Caenorhabditis elegans 31     33 µM Y 24134630
Psora-4 Caenorhabditis elegans 42     88 µM Y 24134630
Trequinsin hydrochloride Caenorhabditis elegans 27     88 µM Y 24134630
Tyrphostin AG 1478 Caenorhabditis elegans 11     33 µM Y 24134630
Vinpocetine Caenorhabditis elegans 15     33 µM Y 24134630
MPTP Caenorhabditis elegans 8   N2 10 nM Y 24199155
Piericidin A Caenorhabditis elegans 5   N2 100 nM Y 24199155
Rotenone Caenorhabditis elegans 10   N2 100 nM Y 24199155
Vincristine sulfate Caenorhabditis elegans 12     88 µM Y 24134630
Korean red ginseng tonic Drosophila melanogaster 13.5   w1118 12 µg/ml Y 24265871
Korean red ginseng tonic Drosophila melanogaster 14.5   w1118 1.2 µg/ml Y 24265871
Vitamin D3 Caenorhabditis elegans 23   N2 1000 µg/ml Y 24304198
Korean red ginseng tonic Drosophila melanogaster 5.7   w1118 0.12 µg/ml N 24265871
AU701 Drosophila melanogaster 1.2   Canton S 0.30% N 24305778
AU701 Drosophila melanogaster 11.4   Canton S 0.30% Y 24305778
CU701 Drosophila melanogaster 0   Canton S 0.30% N 24305778
AU701 Drosophila melanogaster -0.7   Canton S 0.30% N 24305778
CU701 Drosophila melanogaster 6   Canton S 0.30% N 24305778
Polydatin Caenorhabditis elegans 30   N2 1 mM Y 24305800
CU701 Drosophila melanogaster 16.9   Canton S 0.30% Y 24305778
Cranberry extract Drosophila melanogaster 30.1   Canton S 0.02 Y 24316039
Korean mistletoe extract Drosophila melanogaster 19.9   Canton S 50 µg/ml Y 24337961
Ludwigia octovalvis extract Drosophila melanogaster 16.1   Canton S 100 µg/ml Y 24338263
Korean mistletoe extract Caenorhabditis elegans 9.6   N2 50 µg/ml Y 24337961
Ludwigia octovalvis extract Drosophila melanogaster 24.2   Canton S 100 µg/ml Y 24338263
Glyceollin I Saccharomyces cerevisiae 40     12.5 nM Y 24399048
Lithium Chloride Caenorhabditis elegans 11   JK1107 (glp-1) 10 mM Y 24398558
Glyceollin I Saccharomyces cerevisiae       100000 nM ND 24399048
Glyceollin I Saccharomyces cerevisiae       0.5 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       5 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       10 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       50 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       1 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       100 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       1250 nM Y 24399048
Glyceollin I Saccharomyces cerevisiae       25000 nM Y 24399048
Rapamycin Mus musculus 7   C57BL/6J 14 ppm Y 24409289
Glyceollin I Saccharomyces cerevisiae       25 nM Y 24399048
Rapamycin Mus musculus 14   C57BL/6J 14 ppm Y 24409289
Celastrol Caenorhabditis elegans 13.8   N2 7 µmol/l Y 24416295
Celastrol Caenorhabditis elegans 17.4   N2 7 µmol/l Y 24416295
Sesamin Caenorhabditis elegans 10.5   N2 3.1 µg Y 24549958
Sesamin Caenorhabditis elegans 0.8   N2 25 µg N 24549958
Sesamin Caenorhabditis elegans 10.9   N2 12.5 µg Y 24549958
Cranberry extract Caenorhabditis elegans 12.8   N2 2 mg/ml Y 24566444
Sesamin Caenorhabditis elegans 14.1   N2 6.3 µg Y 24549958
SRT1720 Mus musculus 8.8   C57BL/6J 100 mg/kg body weight N 24582957
N-acetylglucosamine Caenorhabditis elegans 50   N2 10 mM Y 24630720
Cranberry extract Caenorhabditis elegans 20   N2 2 mg/ml Y 24566444
Cranberry extract Caenorhabditis elegans 14.4   N2 2 mg/ml Y 24566444
Caffeine Caenorhabditis elegans -89.5   N2 100 mM Y 24764514
Caffeine Caenorhabditis elegans -82.8   N2 75 mM Y 24764514
Caffeine Caenorhabditis elegans -11.6   N2 7.5 mM Y 24764514
Caffeine Caenorhabditis elegans -24.4   N2 30 mM Y 24764514
Caffeine Caenorhabditis elegans -13.6   N2 5 mM Y 24764514
Caffeine Caenorhabditis elegans 7.7   N2 0.5 mM Y 24764514
Caffeine Caenorhabditis elegans 8.7   N2 7.5 mM Y 24764514
Caffeine Caenorhabditis elegans 16.9   N2 10 mM Y 24764514
Caffeine Caenorhabditis elegans 17.2   N2 2.5 mM Y 24764514
Caffeine Caenorhabditis elegans 19.6   N2 7.5 mM Y 24764514
Caffeine Caenorhabditis elegans 21.6   N2 20 mM Y 24764514
Caffeine Caenorhabditis elegans -40.9   N2 50 mM Y 24764514
Caffeine Caenorhabditis elegans 10.8   N2 5 mM Y 24764514
Glycerol Brachionus manjavacas 51     274 mM Y 24835191
Alpha-ketoglutarate Caenorhabditis elegans 29.4   N2 8 mM Y 24828042
Beta-caryophyllene Caenorhabditis elegans 11.2   N2 25 µM Y 24835194
Caffeine Caenorhabditis elegans 36.7   N2 10 mM Y 24764514
Beta-caryophyllene Caenorhabditis elegans 22.2   N2 50 µM Y 24835194
Beta-caryophyllene Caenorhabditis elegans 14.9   N2 100 µM Y 24835194
Caffeine Caenorhabditis elegans 28.5   N2 5 mM Y 24764514
Metformin Caenorhabditis elegans 6.3   N2 100 mM N 24889636
Metformin Caenorhabditis elegans 13   N2 12.5 mM Y 24889636
Metformin Caenorhabditis elegans 17   N2 6.25 mM Y 24889636
Metformin Caenorhabditis elegans 29.7   N2 25 mM Y 24889636
Metformin Caenorhabditis elegans 9.4   N2 50 mM N 24889636
Metformin Caenorhabditis elegans 30.6   N2 25 mM Y 24889636
CU701 Drosophila melanogaster 5.4   Canton S 0.30% Y 24305778
Metformin Caenorhabditis elegans 44   N2 25 mM Y 24889636
Metformin Caenorhabditis elegans 47.4   N2 25 mM Y 24889636
Metformin Caenorhabditis elegans -4.7   N2 25 mM N 24889636
Huanshao dan Caenorhabditis elegans 38.3   N2 6.8 g/L Y 24952637
Erchen wan Caenorhabditis elegans 21.8   N2 1.5 g/L N 24952637
Metformin Caenorhabditis elegans 57.3   N2 25 mM Y 24889636
Liuwei dihuang wan Caenorhabditis elegans 12.6   N2 4.2 g/L Y 24952637
Shengmai yin Caenorhabditis elegans 47.3   N2 48.0 g/L Y 24952637
Emblica officinalis Drosophila melanogaster 5.9     20 ml Y 24967413
Emblica officinalis Drosophila melanogaster 5.9     30 ml Y 24967413
Turmeric powder Drosophila melanogaster 17.6     5 g/L Y 24967413
Shiquan dabu wan Caenorhabditis elegans 14.5   N2 6.2 g/L Y 24952637
Turmeric powder Drosophila melanogaster 17.6     7 g/L Y 24967413
Turmeric powder Drosophila melanogaster 2.9     2.5 g/L Y 24967413
Green tea polyphenols Drosophila melanogaster 19   w1118 10 mg/ml Y 25058464
D-beta-hydroxybutyrate Caenorhabditis elegans 26   N2 20 mM Y 25127866
Curcumin Drosophila melanogaster 3   Canton S 50 µM ND 25173182
Curcumin Drosophila melanogaster -1   Canton S 50 µM ND 25173182
Curcumin Drosophila melanogaster 9   Canton S 25 µM ND 25173182
Curcumin Drosophila melanogaster 4   Canton S 25 µM ND 25173182
Curcumin Drosophila melanogaster 2   Canton S 5 µM ND 25173182
Curcumin Drosophila melanogaster 19   Canton S 10 µM ND 25173182
Curcumin Drosophila melanogaster 34   Canton S 10 µM ND 25173182
Astragalus polysaccharide Caenorhabditis elegans 7   N2 50 µg/ml N 25186652
Astragalus polysaccharide Caenorhabditis elegans 19.6   N2 400 µg/ml Y 25186652
Astragalus polysaccharide Caenorhabditis elegans 22.8   N2 100 µg/ml Y 25186652
Astragalus polysaccharide Caenorhabditis elegans 20.7   N2 200 µg/ml Y 25186652
Astragalus polysaccharide Caenorhabditis elegans 30.8   N2 600 µg/ml Y 25186652
Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate Aeolosoma viride 98.6     2.5 µM Y 25190068
Curcumin Drosophila melanogaster 6   Canton S 5 µM ND 25173182
Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate Aeolosoma viride 157.3     1.25 µM Y 25190068
Astragalus polysaccharide Caenorhabditis elegans 24.7   N2 200 µg/ml Y 25186652
EUK-134 Aeolosoma viride 48.8     3.1 µM Y 25190068
Mulberry leaf polyphenols Caenorhabditis elegans 22.5   N2 25 mg/mL Y 25323576
EUK-134 Aeolosoma viride 20.2     12.5 µM Y 25190068
EUK-134 Aeolosoma viride 26.4     1.6 µM Y 25190068
Nordihydroguaiaretic acid Mus musculus 12   B6C3F1 3.5 g/kg diet Y 25380600
Nordihydroguaiaretic acid Mus musculus -1   B6C3F1 1.5 g/kg diet N 25380600
Nordihydroguaiaretic acid Mus musculus 7.7   B6C3F1 2.5 g/kg diet N 25380600
Nordihydroguaiaretic acid Drosophila melanogaster 23   Oregon-R-C 3 mg/ml Y 25380600
Nordihydroguaiaretic acid Mus musculus 1.2   B6C3F1 4.5 g/kg diet N 25380600
Nordihydroguaiaretic acid Drosophila melanogaster     Oregon-R-C 1 mg/ml N 25380600
Royalactin Caenorhabditis elegans 26.8   N2 0.04 µg/ml Y 25456847
Royalactin Caenorhabditis elegans 29.1   N2 0.4 µg/ml Y 25456847
Edetate Calcium Disodium Caenorhabditis elegans 21.4   N2   Y 25554795
Cinnamon Extract Drosophila melanogaster 37   w1118 75 mg/ml Y 25456850
Dibromoacetic acid Caenorhabditis elegans 14.6   N2 100 µM Y 25556763
N-nitrosodimethylamine Caenorhabditis elegans 5.5   N2 50 µM Y 25556763
Pomegrenate juice Drosophila melanogaster 8   Canton S 0.1 Y 25566518
Pomegrenate juice Drosophila melanogaster 18   Canton S 0.1 Y 25566518
Royalactin Caenorhabditis elegans 33.9   N2 1.6 µg/ml Y 25456847
Cinnamon Extract Drosophila melanogaster 17   w1118 25 mg/ml Y 25456850
Resveratrol Nothobranchius guentheri 14   TZ 97-2 200 µg/g Y 25569124
Ivabradine Mus musculus 6.2   C57BL/6J 50 mg/kg/day Y 25589054
Resveratrol Nothobranchius guentheri 19   TZ 97-2 200 µg/g Y 25569124
Genistein Caenorhabditis elegans 10   N2 50 µM Y 25593647
Genistein Caenorhabditis elegans 27.9   N2 100 µM Y 25593647
Specioside Caenorhabditis elegans 15.5   N2 25 µM Y 25619942
Specioside Caenorhabditis elegans 11.8   N2 50 µM Y 25619942
Specioside Caenorhabditis elegans 8.9   N2 5 µM Y 25619942
Agmatine Caenorhabditis elegans 1   N2 100 µM N 25643626
Agmatine Caenorhabditis elegans 16   N2 1 mM Y 25643626
Agmatine Caenorhabditis elegans -20   N2 10 mM Y 25643626
Alanine Caenorhabditis elegans 4   N2 5 mM N 25643626
Alanine Caenorhabditis elegans 8   N2 1 mM Y 25643626
Alanine Caenorhabditis elegans 11   N2 10 mM Y 25643626
Alpha-ketoglutarate Caenorhabditis elegans 10   N2 100 µM Y 25643626
Alpha-ketoglutarate Caenorhabditis elegans 7   N2 10 mM N 25643626
Alpha-ketoglutarate Caenorhabditis elegans 11   N2 5 mM Y 25643626
Arginine Caenorhabditis elegans 8   N2 1 mM Y 25643626
Alpha-ketoglutarate Caenorhabditis elegans 15   N2 1 mM Y 25643626
Arginine Caenorhabditis elegans 15   N2 10 mM Y 25643626
Asparagine Caenorhabditis elegans 1   N2 1 mM N 25643626
Asparagine Caenorhabditis elegans -25   N2 10 mM Y 25643626
Asparagine Caenorhabditis elegans 5   N2 5 mM Y 25643626
Beta-alanine Caenorhabditis elegans 5   N2 5 mM N 25643626
Beta-alanine Caenorhabditis elegans 13   N2 1 mM Y 25643626
Caprylate Caenorhabditis elegans 1   N2 100 µM N 25643626
Caprylate Caenorhabditis elegans 7   N2 1 mM Y 25643626
Arginine Caenorhabditis elegans 11   N2 5 mM Y 25643626
Caprylate Caenorhabditis elegans -18   N2 10 mM Y 25643626
Caprylate Caenorhabditis elegans -5   N2 5 mM Y 25643626
Citrate Caenorhabditis elegans -2   N2 10 mM N 25643626
Carnosine Caenorhabditis elegans 4   N2 100 µM Y 25643626
Carnosine Caenorhabditis elegans 1   N2 10 µM N 25643626
Betaine Caenorhabditis elegans 9   N2 1 mM Y 25643626
Creatine Caenorhabditis elegans -20   N2 5 mM Y 25643626
Creatine Caenorhabditis elegans -4   N2 1 mM Y 25643626
Creatine Caenorhabditis elegans -18   N2 10 mM Y 25643626
Cysteine Caenorhabditis elegans 9   N2 1 mM Y 25643626
Cysteine Caenorhabditis elegans 16   N2 5 mM Y 25643626
Carnosine Caenorhabditis elegans 11   N2 1 mM Y 25643626
Cysteine Caenorhabditis elegans 2   N2 10 mM N 25643626
D-alanine Caenorhabditis elegans 16   N2 10 mM Y 25643626
D-alanine Caenorhabditis elegans 14   N2 1 mM Y 25643626
D-aspartate Caenorhabditis elegans 7   N2 1 mM N 25643626
D-alanine Caenorhabditis elegans 16   N2 5 mM Y 25643626
D-aspartate Caenorhabditis elegans 8   N2 10 mM Y 25643626
D-glutamate Caenorhabditis elegans -3   N2 10 mM N 25643626
D-aspartate Caenorhabditis elegans 18   N2 5 mM Y 25643626
D-glutamate Caenorhabditis elegans 14   N2 1 mM Y 25643626
D-glutamate Caenorhabditis elegans 18   N2 5 mM Y 25643626
DL-isocitrate Caenorhabditis elegans -28   N2 10 mM Y 25643626
DL-isocitrate Caenorhabditis elegans 3   N2 1 mM N 25643626
DL-isocitrate Caenorhabditis elegans 13   N2 5 mM Y 25643626
DL-lactate Caenorhabditis elegans 6   N2 5 mM Y 25643626
Galactose Caenorhabditis elegans 1   N2 1 mM N 25643626
DL-lactate Caenorhabditis elegans 2   N2 10 mM N 25643626
Galactose Caenorhabditis elegans 6   N2 10 mM Y 25643626
DL-lactate Caenorhabditis elegans 3   N2 1 mM N 25643626
Gluconate Caenorhabditis elegans 17   N2 5 mM Y 25643626
Gluconate Caenorhabditis elegans 16   N2 10 mM Y 25643626
Gluconate Caenorhabditis elegans 8   N2 1 mM Y 25643626
Glutamate Caenorhabditis elegans 14   N2 1 mM Y 25643626
Glutamate Caenorhabditis elegans -8   N2 10 mM Y 25643626
Glutamine Caenorhabditis elegans 15   N2 1 mM Y 25643626
Glutamate Caenorhabditis elegans 11   N2 5 mM Y 25643626
Glutamine Caenorhabditis elegans -6   N2 10 mM Y 25643626
Glycerol Caenorhabditis elegans 21   N2 10 mM Y 25643626
Glutamine Caenorhabditis elegans 16   N2 5 mM Y 25643626
Glycine Caenorhabditis elegans 3   N2 5 mM N 25643626
Glycine Caenorhabditis elegans 10   N2 1 mM Y 25643626
Glycine Caenorhabditis elegans -4   N2 10 mM N 25643626
Histidine Caenorhabditis elegans 10   N2 5 mM Y 25643626
Histidine Caenorhabditis elegans 4   N2 1 mM N 25643626
Histidine Caenorhabditis elegans 9   N2 5 mM Y 25643626
Histidine Caenorhabditis elegans 12   N2 10 mM Y 25643626
Homocysteine Caenorhabditis elegans 7   N2 5 mM Y 25643626
Inositol Caenorhabditis elegans 3   N2 1 mM Y 25643626
Inositol Caenorhabditis elegans 17   N2 10 mM Y 25643626
Isoleucine Caenorhabditis elegans 3   N2 1 mM N 25643626
Isoleucine Caenorhabditis elegans 3   N2 5 mM N 25643626
Leucine Caenorhabditis elegans 16   N2 1 mM Y 25643626
Isoleucine Caenorhabditis elegans 3   N2 10 mM Y 25643626
Leucine Caenorhabditis elegans 6   N2 5 mM Y 25643626
Leucine Caenorhabditis elegans 7   N2 10 mM Y 25643626
L-histidine methyl ester Caenorhabditis elegans 8   N2 100 µM Y 25643626
L-histidine methyl ester Caenorhabditis elegans 9   N2 1 mM Y 25643626
Homocysteine Caenorhabditis elegans 13   N2 1 mM Y 25643626
L-histidine methyl ester Caenorhabditis elegans 4   N2 10 mM N 25643626
L-theanine Caenorhabditis elegans 14   N2 100 µM Y 25643626
L-theanine Caenorhabditis elegans 8   N2 1 mM Y 25643626
L-theanine Caenorhabditis elegans 10   N2 5 mM Y 25643626
Lysine Caenorhabditis elegans 8   N2 5 mM Y 25643626
L-theanine Caenorhabditis elegans -15   N2 10 mM Y 25643626
Lysine Caenorhabditis elegans 6   N2 10 mM Y 25643626
Lysine Caenorhabditis elegans 7   N2 1 mM Y 25643626
Methionine Caenorhabditis elegans 8   N2 5 mM Y 25643626
Methionine Caenorhabditis elegans 4   N2 1 mM N 25643626
N-acetyl-l-histidine Caenorhabditis elegans 3   N2 100 µM N 25643626
N-acetyl-l-histidine Caenorhabditis elegans 10   N2 10 mM N 25643626
Ornithine Caenorhabditis elegans 3   N2 100 µM N 25643626
Ornithine Caenorhabditis elegans 8   N2 1 mM Y 25643626
Ornithine Caenorhabditis elegans -10   N2 10 mM Y 25643626
Methionine Caenorhabditis elegans 14   N2 10 mM Y 25643626
N-acetyl-l-histidine Caenorhabditis elegans 12   N2 1 mM Y 25643626
Phosphoenolpyruvate Caenorhabditis elegans 12   N2 1 mM Y 25643626
Phosphoenolpyruvate Caenorhabditis elegans 8   N2 10 mM Y 25643626
Picolinic acid Caenorhabditis elegans 7   N2 1 mM Y 25643626
Phosphoenolpyruvate Caenorhabditis elegans 12   N2 5 mM Y 25643626
Proline Caenorhabditis elegans 17   N2 1 mM Y 25643626
Proline Caenorhabditis elegans 8   N2 5 mM Y 25643626
Proline Caenorhabditis elegans 19   N2 5 mM Y 25643626
Putrescine Caenorhabditis elegans 10   N2 1 mM Y 25643626
Putrescine Caenorhabditis elegans -13   N2 10 mM Y 25643626
Ribose Caenorhabditis elegans 9   N2 1 mM Y 25643626
Ribose Caenorhabditis elegans 9   N2 5 mM Y 25643626
Putrescine Caenorhabditis elegans 1   N2 100 µM N 25643626
Proline Caenorhabditis elegans 18   N2 10 mM Y 25643626
Serine Caenorhabditis elegans 9   N2 10 mM Y 25643626
Ribose Caenorhabditis elegans 1   N2 10 mM N 25643626
Serine Caenorhabditis elegans 8   N2 1 mM Y 25643626
Serine Caenorhabditis elegans 18   N2 5 mM Y 25643626
Succinate Caenorhabditis elegans 4   N2 10 mM N 25643626
Serine Caenorhabditis elegans 22   N2 10 mM Y 25643626
Succinate Caenorhabditis elegans 10   N2 5 mM Y 25643626
Succinate Caenorhabditis elegans 11   N2 1 mM Y 25643626
Taurine Caenorhabditis elegans 11   N2 1 mM Y 25643626
Taurine Caenorhabditis elegans 6   N2 5 mM Y 25643626
Taurine Caenorhabditis elegans -4   N2 10 mM Y 25643626
Threonine Caenorhabditis elegans 3   N2 5 mM N 25643626
Tryptophan Caenorhabditis elegans 14   N2 1 mM Y 25643626
Threonine Caenorhabditis elegans 8   N2 10 mM Y 25643626
Threonine Caenorhabditis elegans 0   N2 1 mM Y 25643626
Tryptophan Caenorhabditis elegans 6   N2 5 mM Y 25643626
Tryptophan Caenorhabditis elegans 9   N2 1 mM Y 25643626
Tyrosine Caenorhabditis elegans 2   N2 10 mM N 25643626
Tryptophan Caenorhabditis elegans 1   N2 10 mM N 25643626
Tyrosine Caenorhabditis elegans 10   N2 1 mM Y 25643626
Tyrosine Caenorhabditis elegans 5   N2 5 mM Y 25643626
Valine Caenorhabditis elegans 13   N2 1 mM N 25643626
Valine Caenorhabditis elegans 8   N2 5 mM Y 25643626
Xylose Caenorhabditis elegans 6   N2 10 mM Y 25643626
Valine Caenorhabditis elegans -1   N2 10 mM Y 25643626
Rifampicin Caenorhabditis elegans 42.6   N2 5 µM Y 25720500
Rifampicin Caenorhabditis elegans 34.8   N2 1 µM Y 25720500
Rifampicin Caenorhabditis elegans 37.9   N2 50 µM Y 25720500
Rifampicin Caenorhabditis elegans 43.4   N2 200 µM Y 25720500
Rifampicin Caenorhabditis elegans 49.2   N2 100 µM Y 25720500
Rifampicin Caenorhabditis elegans 45.3   N2 10 µM Y 25720500
Rifampicin Caenorhabditis elegans 50.8   N2 20 µM Y 25720500
Rifampicin Caenorhabditis elegans 55.8   N2 50 µM Y 25720500
Rifampicin Caenorhabditis elegans 45.4   N2 50 µM Y 25720500
Rifampicin Caenorhabditis elegans 56.1   N2 30 µM Y 25720500
Rifamycin SV Caenorhabditis elegans 20.9   N2 50 µM Y 25720500
Aspirin Acheta domesticus 49     2.263x10^4 g aspirin/g food Y 25833406
Aspirin Acheta domesticus 67     5.65x10^5 g aspirin/g food Y 25833406
Aspirin Acheta domesticus 77     2.263x10^4 g aspirin/g food Y 25833406
Aspirin Acheta domesticus 52     5.65x10^5 g aspirin/g food Y 25833406
Aspirin Acheta domesticus 134     5.65x10^5 g aspirin/g food Y 25833406
Metformin Acheta domesticus 39     1.78x10^3 g metformin/g diet Y 25833406
Metformin Acheta domesticus 79     1.78x10^3 g metformin/g diet Y 25833406
Recombinant buckwheat trypsin inhibitor Caenorhabditis elegans 15.6   N2 5 µM Y 25959406
Curcumin Caenorhabditis elegans 22.5   N2 100 µM Y 25959406
Aspirin Acheta domesticus 111     2.263x10^4 g aspirin/g food Y 25833406
Recombinant buckwheat trypsin inhibitor Caenorhabditis elegans 7.5   N2 2.5 µM Y 25959406
Soybean trypsin inhibitor Caenorhabditis elegans 8.7   N2 5 µM Y 25959406
Garlic extract Caenorhabditis elegans 21   N2 50 ppm Y 25940980
Recombinant buckwheat trypsin inhibitor Caenorhabditis elegans 23.7   N2 10 µM Y 25959406
Soybean trypsin inhibitor Caenorhabditis elegans 10.4   N2 10 µM Y 25959406
Otophylloside B Caenorhabditis elegans 30   N2 50 µM Y 26112394
Trametinib Drosophila melanogaster 12   white Dahomey 15.6 µM Y 26119340
Beta-Guanidinopropionic acid Drosophila melanogaster 9.1   w1118 900 mM Y 26120775
Beta-Guanidinopropionic acid Drosophila melanogaster 13.3   w1118 900 mM Y 26120775
Curcumin Drosophila melanogaster -23.4   Ra 100 mM Y 26136617
(Iso)lappaol A Caenorhabditis elegans 11.2   N2 100 µM Y 26141518
Arctigenin Caenorhabditis elegans 6.7   N2 10 µM Y 26141518
Arctigenin Caenorhabditis elegans 13.7   N2 100 µM Y 26141518
Arctiin Caenorhabditis elegans 8.9   N2 10 µM Y 26141518
Arctiin Caenorhabditis elegans 15.3   N2 100 µM Y 26141518
Lappaol C Caenorhabditis elegans 11.3   N2 10 µM Y 26141518
Matairesinol Caenorhabditis elegans 14   N2 10 µM Y 26141518
Matairesinol Caenorhabditis elegans 25   N2 100 µM Y 26141518
Lappaol F Caenorhabditis elegans 12.5   N2 100 µM Y 26141518
Verminoside Caenorhabditis elegans 20.8   N2 25 µM Y 26189547
Verminoside Caenorhabditis elegans 8.5   N2 50 µM Y 26189547
Verminoside Caenorhabditis elegans 9.8   N2 5 µM Y 26189547
(R)-2-hydroxyglutarate Caenorhabditis elegans 42.9     8 mM Y 26190651
Alpha-ketoglutarate Caenorhabditis elegans 47.9     8 mM Y 26190651
(S)-2-hydroxyglutarate Caenorhabditis elegans 31.8     8 mM Y 26190651
Lappaol C Caenorhabditis elegans 11.5   N2 100 µM Y 26141518
Panax notoginseng main root polysaccharide Caenorhabditis elegans 21   N2 0.1 mg/ml ND 26234580
Epigallocatechin-3-gallate Drosophila melanogaster 15.7     10 mg/ml Y 26375250
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside Caenorhabditis elegans 17   N2 50 µM Y 26433219
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside Caenorhabditis elegans 17.3   N2 25 µM Y 26433219
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside Caenorhabditis elegans 10.1   N2 5 µM Y 26433219
Folic acid Caenorhabditis elegans 0.2   N2 50 µM N 26546011
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside Caenorhabditis elegans 39   N2 25 µM Y 26433219
Folic acid Caenorhabditis elegans 26.6   N2 25 µM Y 26546011
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside Caenorhabditis elegans 5.8   N2   Y 26433219
Folic acid Caenorhabditis elegans 17.1   N2 10 µM Y 26546011
Geldanamycin Caenorhabditis elegans 2   N2 20 µM N 26676933
Folic acid Caenorhabditis elegans 15   N2 25 µM Y 26546011
Rapamycin Caenorhabditis elegans 18.9   N2 10 µM Y 26676933
LY-294002 Caenorhabditis elegans 20.9   N2 100 µM Y 26676933
Caffeine Caenorhabditis elegans -96   N2 60 mM Y 26696878
Caffeine Caenorhabditis elegans -92   N2 45 mM Y 26696878
Allantoin Caenorhabditis elegans 21.9   N2 250 µM Y 26676933
Trichostatin A Caenorhabditis elegans 22.1   N2 100 µM Y 26676933
Caffeine Caenorhabditis elegans -60   N2 30 mM Y 26696878
Caffeine Caenorhabditis elegans 0   N2 5 mM N 26696878
Caffeine Caenorhabditis elegans 24   N2 15 mM Y 26696878
Caffeine Caenorhabditis elegans 8   N2 5 mM Y 26696878
Caffeine Caenorhabditis elegans 35   N2 5 mM Y 26696878
Caffeine Caenorhabditis elegans 0   N2 5 mM N 26696878
Caffeine Caenorhabditis elegans 65   N2 5 mM Y 26696878
Minocycline Drosophila melanogaster 26.7   Canton S 0.05mM Y 29152127
Minocycline Drosophila melanogaster 15.7   Canton S 0.36mM Y 29152127
Minocycline Drosophila melanogaster 13.6   Canton S 0.05mM Y 29152127
Minocycline Drosophila melanogaster 7.7   Canton S 0.36mM Y 29152127
Minocycline Drosophila melanogaster 16.9   w1118 0.05mM Y 29152127
Minocycline Drosophila melanogaster 6   w1118 0.36mM Y 29152127
Minocycline Drosophila melanogaster 22.9   w1118 0.05mM Y 29152127
Minocycline Drosophila melanogaster 15.6   w1118 0.36mM Y 29152127
Hydralazine Caenorhabditis elegans 23.29   N2 100 µM Y 29263362
Hydralazine Caenorhabditis elegans 14.83   N2 50 µM Y 29263362
Metformin Caenorhabditis elegans 13.79   N2 20 mM Y 29263362
Ikarugamycin Caenorhabditis elegans 22.25   fem-1(ˆ’);dal-1(ˆ’) 5 µM Y 29273768
Metformin Caenorhabditis elegans 43.65   N2 50 mM Y 29027899
Alaskan Blueberry Extract Caenorhabditis elegans 56   N2 60 µg/mL ND 27486399
Resveratrol Caenorhabditis elegans 0.87   N2 100 µM Y 27882602
trans-2,40,5-trihydroxystilbene Caenorhabditis elegans 6.44   N2 100 µM Y 27882602
A.sinensis root peptides Caenorhabditis elegans     N2 2 mg/ml ND 26941890
Aspirin Caenorhabditis elegans 14.24   N2 100 µM Y 28910305
Guduchi Churna Drosophila melanogaster 193.83   Oregon-K 0.25g/100ml Y 28827958
Guduchi Churna Drosophila melanogaster 155.65   Oregon-K 0.50g/100ml Y 28827958
Guduchi Churna Drosophila melanogaster 85.91   Oregon-K 0.7 g/100 ml Y 28827958
Hon Tsai Tai Extract Caenorhabditis elegans 7.97   N2 2 mg/ml Y 26726147
d-Allulose Caenorhabditis elegans 4   N2 5 mM Y 28965946
d-Allulose Caenorhabditis elegans 12   N2 10 mM Y 28965946
d-Allulose Caenorhabditis elegans 7   N2 25 mM Y 28965946
α‐ketoisovalerate Caenorhabditis elegans 35.02   N2 10 mM Y 26729005
α‐keto‐β‐methylvalerate Caenorhabditis elegans 20.77   N2 10 mM Y 26729005
4‐methyl‐2‐oxovalerate Caenorhabditis elegans 12.44   N2 10 mM Y 26729005
Pyruvate Caenorhabditis elegans -25.35   N2 8 mM Y 26729005
Pyruvate Caenorhabditis elegans 25.17   N2 8 mM Y 26729005
2,4-pyridinedicarboxylic acid Caenorhabditis elegans -17.13   N2 10 mM Y 26729005
Spermidine Mus musculus 23.79   C57BL/6 Drinking water supplemented with 3mM Y 28386016
Rotenone Drosophila melanogaster -21.14   Dahomey 100 µM Y 27076081
Paraquat Drosophila melanogaster -41.4   Dahomey 1 mM Y 27076081
Alkaline Water Mus musculus 1.8   CD1   Y 27340414
Dafachronic Acid Caenorhabditis elegans 23.44   N2 0.1µM Y 26691751
Nitrophenyl piperazine containing compound 1 Caenorhabditis elegans 72.5   N2 50 µM Y 27220516
Nitrophenyl piperazine containing compound 1 Caenorhabditis elegans 23   N2 10 µM Y 27220516
Nitrophenyl piperazine containing compound 1 Caenorhabditis elegans -23.08   N2 500 µM Y 27220516
M084 Caenorhabditis elegans 9.11   N2 50 µM Y 27854075
M084 Caenorhabditis elegans 19.12   N2 500 µM Y 27854075
M084 Caenorhabditis elegans 6.92   N2 1 mM Y 27854075
Colanic acid Drosophila melanogaster 20   OreR 35 µg/ml Y 28622510
Colanic acid Drosophila melanogaster 17   OreR 350 µg/ml Y 28622510
Colanic acid Caenorhabditis elegans 9   N2   Y 28622510
Colanic acid Caenorhabditis elegans 24   N2   Y 28622510
Colanic acid Caenorhabditis elegans 13   N2   Y 28622510
Colanic acid Caenorhabditis elegans 12   N2   Y 28622510
Colanic acid Caenorhabditis elegans 11   N2   Y 28622510
Colanic acid Caenorhabditis elegans 10   N2   Y 28622510
Colanic acid Caenorhabditis elegans 3   N2   N 28622510
Colanic acid Caenorhabditis elegans -1   N2   N 28622510
Colanic acid Caenorhabditis elegans 4   N2   N 28622510
Colanic acid Caenorhabditis elegans 6   N2   Y 28622510
Colanic acid Caenorhabditis elegans 6   N2   Y 28622510
Colanic acid Caenorhabditis elegans 6   N2   Y 28622510
Colanic acid Caenorhabditis elegans 11   N2   Y 28622510
Colanic acid Caenorhabditis elegans 14   N2   Y 28622510
Colanic acid Caenorhabditis elegans 13   N2   Y 28622510
Colanic acid Caenorhabditis elegans 6   isp-1(qm150)   N 28622510
Colanic acid Caenorhabditis elegans 1   isp-1(qm150)   N 28622510
Colanic acid Caenorhabditis elegans 0   isp-1(qm150)   N 28622510
Colanic acid Caenorhabditis elegans 4   nuo-6(qm200)   N 28622510
Colanic acid Caenorhabditis elegans -5   nuo-6(qm200)   N 28622510
Colanic acid Caenorhabditis elegans 1   nuo-6(qm200)   N 28622510
Colanic acid Caenorhabditis elegans 17   N2   Y 28622510
Colanic acid Caenorhabditis elegans 14   N2   Y 28622510
Colanic acid Caenorhabditis elegans 16   N2   Y 28622510
Powdered Broccoli Lyophilisate Tribolium castaneum     San Bernardino 1% Y 23321956
Reserpine Caenorhabditis elegans 25.75   N2 60 µM Y 27966489
Echinacoside Caenorhabditis elegans 7.6   N2 150 µM Y 26027643
Echinacoside Caenorhabditis elegans 15.82   N2 300 µM Y 26027643
Echinacoside Caenorhabditis elegans 9.47   N2 600 µM Y 26027643
Sesamin Caenorhabditis elegans 9.55   N2 5.75 µg Y 28239780
Nicotinamide riboside Mus musculus 4.7   C57BL/6J 400 mg/kg/day Y 27127236
Sorbitol Caenorhabditis elegans 17.9   N2 1% Y 26579191
Sorbitol Caenorhabditis elegans 32.7   N2 2.50% Y 26579191
Sorbitol Caenorhabditis elegans 16   N2 12.50% Y 26579191
Sorbitol Caenorhabditis elegans 27.12   N2 5% Y 26579191
Piceatannol Caenorhabditis elegans 18.3   N2 50 µM Y 28128482
Piceatannol Caenorhabditis elegans 18.3   N2 100 µM Y 28128482
Buthionine Sulfoximine Musca Domestica -30     3 mM Y 2866912
2-Oxothiazolidine-4-carboxylate Musca Domestica -24     3 mM Y 2866912
Quercetin Mus musculus -5.8   LACA 10 mg/day N 7140862
Crocus Sativus Aqueous Extract Drosophila melanogaster 18.3   w1118 1% Y 27878268
Crocus Sativus Aqueous Extract Drosophila melanogaster 8.8   w1118 1% Y 27878268
Calycosin Caenorhabditis elegans 6.24   N2 50 µM Y 28434978
Calycosin Caenorhabditis elegans 15.64   N2 100 µM Y 28434978
Calycosin Caenorhabditis elegans 17.8   N2 400 µM Y 28434978
Calycosin Caenorhabditis elegans 24.86   N2 200 µM Y 28434978
Rutin Drosophila melanogaster 17   Canton-S 200 µM Y 28389882
Rutin Drosophila melanogaster 23.52   Canton-S 400 µM Y 28389882
Rutin Drosophila melanogaster -23   Canton-S 600 µM Y 28389882
Rutin Drosophila melanogaster -38   Canton-S 800 µM Y 28389882
Rutin Drosophila melanogaster 30   Canton-S 200 µM Y 28389882
Rutin Drosophila melanogaster 43.33   Canton-S 400 µM Y 28389882
Rutin Drosophila melanogaster -13.33   Canton-S 600 µM Y 28389882
Rutin Drosophila melanogaster -16.66   Canton-S 800 µM Y 28389882
Oleic Acid Caenorhabditis elegans 17.29   N2 800 µM Y 28379943
Palmitoleic acid Caenorhabditis elegans 17.09   N2 800 µM Y 28379943
cis-vaccenic acid Caenorhabditis elegans 13.06   N2 800 µM Y 28379943
Fructose Caenorhabditis elegans 21.96   N2 55 mM Y 27680107
Fructose Caenorhabditis elegans 45.66   N2 100 mM Y 27680107
Fructose Caenorhabditis elegans -31.79   N2 555 mM Y 27680107
Glucose Caenorhabditis elegans -46.8   N2 111 mM Y 27680107
Silymarin Caenorhabditis elegans 4.55   N2 10 µM Y 28039083
Silymarin Caenorhabditis elegans 13.64   N2 50 µM Y 28039083
Silychristin A/B Caenorhabditis elegans 7.06   N2 10 µM Y 28039083
Silydianin Caenorhabditis elegans 5.88   N2 10 µM Y 28039083
Silybin A/B Caenorhabditis elegans 9.04   N2 10 µM Y 28039083
Isosilybin A/B Caenorhabditis elegans 6.82   N2 10 µM Y 28039083
2,3-dehydrosilybin Caenorhabditis elegans 2.16   N2 5 µM Y 28039083
2,3-dehydrosilybin Caenorhabditis elegans 10.15   N2 10 µM Y 28039083
2,3-Dehydrosilybin A Caenorhabditis elegans 12.55   N2 10 µM Y 28039083
2,3-Dehydrosilybin B Caenorhabditis elegans 7.18   N2 10 µM Y 28039083
7-methyl-Dehydrosilybin Caenorhabditis elegans -9   N2 10 µM Y 28039083
Glucose Caenorhabditis elegans -18.69   N2 400 mM Y 27776915
18α-Glycyrrhetinic acid Caenorhabditis elegans 6.25   N2 10 µg/ml N 26886723
18α-Glycyrrhetinic acid Caenorhabditis elegans 11.76   N2 100 µg/ml Y 26886723
18α-Glycyrrhetinic acid Caenorhabditis elegans 22   N2 20 µg/mL Y 26886723
Dimethyl Sulfide Drosophila melanogaster 13.56   w1118 10 µM Y 27790859
Dimethyl Sulfide Drosophila melanogaster 24.25   w1118 100 µM Y 27790859
Dimethyl Sulfide Drosophila melanogaster 16.04   w1118 1 mM Y 27790859
Dimethyl Sulfide Caenorhabditis elegans 8.43   N2 1 µM Y 27790859
Dimethyl Sulfide Caenorhabditis elegans 24.33   N2 10 µM Y 27790859
Dimethyl Sulfide Caenorhabditis elegans 20.14   N2 5 µM Y 27790859
Metformin Caenorhabditis elegans 24.46   N2 50 mM Y 27984722
Pyrroloquinoline quinone Caenorhabditis elegans 33.33   N2 500 µM Y 27090484
Pyrroloquinoline quinone Caenorhabditis elegans 44.44   N2 1 mM Y 27090484
ursolic acid Caenorhabditis elegans 32.48   N2 25 µM Y 27773812
Vitamin D3 Caenorhabditis elegans 10.98   N2 25 µM Y 27783938
Vitamin D3 Caenorhabditis elegans 28.77   N2 50 µM Y 27783938
Vitamin D3 Caenorhabditis elegans 23.29   N2 100 µM Y 27783938
Vitamin D3 Caenorhabditis elegans 47.95   N2 250 µM Y 27783938
Urolithin A Caenorhabditis elegans 24   N2 10 µM Y 27400265
Urolithin A Caenorhabditis elegans 40.7   N2 30 µM Y 27400265
Urolithin A Caenorhabditis elegans 37.5   N2 50 µM Y 27400265
Urolithin B Caenorhabditis elegans 36.6   N2 50 µM Y 27400265
Urolithin C Caenorhabditis elegans 36   N2 50 µM Y 27400265
Urolithin D Caenorhabditis elegans 19   N2 50 µM Y 27400265
Resveratrol Caenorhabditis elegans 22.2   N2 100 µM Y 27190265
Resveratrol Caenorhabditis elegans 23.7   N2 500 µM Y 27190265
Resveratrol Caenorhabditis elegans 30.4   N2 1 mM Y 27190265
Oxyresveratrol Caenorhabditis elegans 7.4   N2 100 µM Y 27190265
Oxyresveratrol Caenorhabditis elegans 17.8   N2 500 µM Y 27190265
Oxyresveratrol Caenorhabditis elegans 31.1   N2 1 mM Y 27190265
Enalapril Rattus norvegicus 21.36   Wistar 10 mg/kg/day Y 17557916
Losartan Rattus norvegicus 19.32   Wistar 30 mg/kg/day Y 17557916
jujube fruit powder Drosophila melanogaster 11.1   w1118 150 mg/ml Y 28251407
Butylated hydroxyanisole Caenorhabditis elegans 6.38   N2 25 µM Y 28054425
Paraquat Caenorhabditis elegans 13.53   N2 100 µM Y 28054425
Epicatechin Drosophila melanogaster 7.5   Canton S 1 µM Y 28066251
Quercetin Drosophila melanogaster 13   Canton-S 1 µM Y 28066251
Epicatechin Drosophila melanogaster 16   Canton-S 1 µM Y 28066251
Ibuprofen Drosophila melanogaster 23   Canton-S 1 µM Y 28066251
Salicylamine Caenorhabditis elegans 32   N2 100 µM Y 27514077
Salicylamine Caenorhabditis elegans 56   N2 500 µM Y 27514077
Oleanolic acid Caenorhabditis elegans 11.18   N2 200 µM Y 26592451
Oleanolic acid Caenorhabditis elegans 16.63   N2 300 µM Y 26592451
Zinc Sulfate Caenorhabditis elegans -14   N2 500 µM Y 27078872
TPEN Caenorhabditis elegans 43   N2 200 µM Y 27078872
Rapamycin Mus musculus 16   C57BL/6JNia 8 mg/kg/day Y 27549339
Rapamycin Mus musculus 0   C57BL/6JNia 8 mg/kg/day N 27549339
Rapamycin Mus musculus 8   C57BL/6JNia 128 ppm Y 27549339
Rapamycin Mus musculus 8   C57BL/6JNia 128 ppm Y 27549339
Rapamycin Mus musculus 26   C57BL/6JNia 8 mg/kg/day Y 27549339
Rapamycin Mus musculus 36.7   C57BL/6JNia 128 ppm Y 27549339
Wortmannin Caenorhabditis elegans -4.1   N2 1 µM Y 23543623
Pictilisib Caenorhabditis elegans 9.6   N2 1 µM Y 23543623
Phosphatidylinositol ether lipid analogue 6 Caenorhabditis elegans 10   N2 1 µM Y 23543623
Phosphatidylinositol ether lipid analogue 24 Caenorhabditis elegans 14   N2 1 µM Y 23543623
Chlorophyll Caenorhabditis elegans 13.54   N2 1 µg/ml Y 27077003
Chlorophyll Caenorhabditis elegans 23.37   N2 10 µg/ml Y 27077003
Chlorophyll Caenorhabditis elegans 25.96   N2 40 µg/ml Y 27077003
Chlorophyll Caenorhabditis elegans 13.9   N2 80 µg/ml Y 27077003
Chlorophyll Caenorhabditis elegans 11.18   N2 100 µg/ml Y 27077003
Spermidine Mus musculus 10.6   C57BL/6J 0.3mM Y 27841876
Spermidine Mus musculus 6.5   C57BL/6J 3 mM Y 27841876
Rotenone Nothobranchius furzeri 8.1   MZM-0410 15 pM Y 27135165
Rotenone Nothobranchius furzeri -20.09   MZM-0410 150 pM Y 27190265
Chlorophytum borivilianum polysaccharide extract Caenorhabditis elegans 10   CB5586 1 ng/ml Y 28727758
Resveratrol Caenorhabditis elegans 5   CB5586 10 µg/ml Y 28727758
Chlorophytum borivilianum polysaccharide extract Saccharomyces cerevisiae 15   FY631 1 µg/ml ND 28727758
Chlorophytum borivilianum polysaccharide extract Saccharomyces cerevisiae 37   FY631 100 ng/ml ND 28727758
Chlorophytum borivilianum polysaccharide extract Saccharomyces cerevisiae 55   FY631 10 ng/ml ND 28727758
Chlorophytum borivilianum polysaccharide extract Saccharomyces cerevisiae 23   FY631 1 ng/ml ND 28727758
Resveratrol Saccharomyces cerevisiae 20   FY631 10 µg/ml ND 28727758
Nicotinamide Mus musculus     C57BL/6J 0.5/kg N 29514072
Nicotinamide Mus musculus     C57BL/6J 1 g/kg Y 29514072
Nicotinamide mononucleotide Mus musculus     C57BL/6N 100 mg/kg/day Y 28068222
Nicotinamide mononucleotide Mus musculus     C57BL/6N 300 mg/kg/day N 28068222
Argyreia boseana Caenorhabditis elegans 4.25   N2 1 mg/mL Y 30448258
Argyreia boseana Caenorhabditis elegans -3.8   N2 0.1 mg/mL N 30448258
Argyreia boseana Caenorhabditis elegans -5.4   N2 0.01 mg/mL Y 30448258
Resveratrol Caenorhabditis elegans 60.23   N2 50 µM Y 30320257
Selenocysteine Caenorhabditis elegans 41.9   N2 5 mM Y 30365103
Selenocysteine Caenorhabditis elegans 6.93   N2 5 mM Y 30365103
Lonicera japonica Caenorhabditis elegans 4.04   N2 50 µg/mL N 30266681
Lonicera japonica Caenorhabditis elegans 12.13   N2 100 µg/mL N 30266681
Lonicera japonica Caenorhabditis elegans 15.17   N2 200 µg/mL N 30266681
Lonicera japonica Caenorhabditis elegans 21.87   N2 500 µg/mL Y 30266681
Lonicera japonica Caenorhabditis elegans 17.07   N2 1000 µg/mL Y 30266681
Glucomannan Hydrolysate Drosophila melanogaster 20.2   B18 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 14.88   B18 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 11.7   Oregon-R 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 17.66   Canton-S 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 13.4   DGRP-21 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 10.1   DGRP-38 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 4.6   DGRP-40 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 10   DGRP-85 0.25% w/v Y 30137218
Glucomannan Hydrolysate Drosophila melanogaster 7.3   DGRP-136 0.25% w/v Y 30137218
Polygonum multiflorum Extract Caenorhabditis elegans 1.5   N2 10 µg/mL N 30036983
Polygonum multiflorum Extract Caenorhabditis elegans 4.8   N2 100 µg/mL N 30036983
Polygonum multiflorum Extract Caenorhabditis elegans 18.6   N2 1000 µg/mL Y 30036983
Caffeine Caenorhabditis elegans 15.39   N2 50 µg/mL Y 30061824
Xanthine Caenorhabditis elegans 0.82   N2 50 µg/mL N 30061824
1-methylxanthine Caenorhabditis elegans 5.05   N2 50 µg/mL Y 30061824
3-methylxanthine Caenorhabditis elegans 0.93   N2 50 µg/mL N 30061824
7-methylxanthine Caenorhabditis elegans 8.41   N2 50 µg/mL Y 30061824
1,3-dimemethyl Xan Caenorhabditis elegans 5.54   N2 50 µg/mL Y 30061824
1,7-dimethylxanthine Caenorhabditis elegans 14.75   N2 50 µg/mL Y 30061824
3,7-dimethylxanthine Caenorhabditis elegans -0.84   N2 50 µg/mL N 30061824
Damaurone D Caenorhabditis elegans 7.49   N2 5 µM Y 29992572
Damaurone D Caenorhabditis elegans 12.6   N2 10 µM Y 29992572
Damaurone D Caenorhabditis elegans 16.7   N2 15 µM Y 29992572
2,5-Di-tert-butylhydroquinone Caenorhabditis elegans 15.2   N2 250 µM Y 29988547
2,5-Di-tert-butylhydroquinone Caenorhabditis elegans 14.2   N2 350 µM Y 29988547
Thapsigargin Caenorhabditis elegans 9.6   N2 10 nM Y 29988547
Enoxacin Caenorhabditis elegans 18   N2 100 µg/mL Y 29986212
Mussel peptides Caenorhabditis elegans 29.9   N2 2 mg/ml Y 29796528
Methyl 3,4-dihydroxybenzoate Caenorhabditis elegans 19   N2 160 mg/mL Y 29874838
Resveratrol Caenorhabditis elegans 13.5   N2 100 µM Y 29874838
Rapamycin Caenorhabditis elegans 21.3   N2 100 µM Y 29874838
1,2,3-Triazolyl ester of ketorolac Caenorhabditis elegans 15   N2 50 nM Y 29760342
Tert-butyl hydroperoxide Drosophila melanogaster 18.3   w iso31 1.25 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 12.1   w iso31 2.5 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 19.7   w iso31 5 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 17.4   w iso31 10 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 16.7   w iso31 1 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 11.9   w iso31 5 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 28.4   Canton-S 5 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 22.7   Canton-S 1 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 22.6   Canton-S 5 mM Y 29515102
Tert-butyl hydroperoxide Drosophila melanogaster 12.2   w iso31 1 mM Y 29515102
Arbutin Caenorhabditis elegans 11.89   N2 5 mM Y 29340230
phenylethanoid glycosides Caenorhabditis elegans 15.98   N2 500 µg/mL Y 29185166
Echinacoside Caenorhabditis elegans 13.64   N2 200 µM Y 29185166
Shatavarin IV Caenorhabditis elegans 17.26   N2 50 µM Y 29069955
Emodin Caenorhabditis elegans 9.68   N2 50 µM Y 28831863
Emodin Caenorhabditis elegans 19.74   N2 150 µM Y 28831863
ursolic acid Caenorhabditis elegans 31.3   N2 25 µM Y 28673026
Tomatidine Caenorhabditis elegans 7   N2 25 µM Y 28397803
L2-Cmu Mus musculus 9   CB6F1 20 mg/kg weekly i.p. injection Y 29921922
Dasatinib + Quercetin Mus musculus 6.29   C57BL/6 5 mg/kg (Das) + 50 mg/kg (Que) Y 29988130
Diosgenin Caenorhabditis elegans 20.8   N2 50 µg/mL Y 28954389
Calcium Pantothenate Drosophila melanogaster 27.8   Oregon 0.5g/kg Y 18856647
Sodium Yeast Nucleate Drosophila melanogaster 20.3   Oregon 5 g/kg Y 18856648
Calcium Pantothenate Mus musculus 18.3   C-57 black 300 µg/day Y 13614445
Calcium Pantothenate Mus musculus 20.02   C-57 black 300 µg/day Y 13614445
Disulfiram Rattus norvegicus -21.18   Wistar 1 in 1000 Y 5469789
Disulfiram Rattus norvegicus -5.08   Wistar 1 in 2000 N 5469789
Minocycline Caenorhabditis elegans 5   N2 50 µM N 30479271
Minocycline Caenorhabditis elegans 36   N2 100 µM Y 30479271
Minocycline Caenorhabditis elegans 43   N2 200 µM Y 30479271
Minocycline Caenorhabditis elegans 6   N2 50 µM Y 30479271
Minocycline Caenorhabditis elegans 33   N2 100 µM Y 30479271
Minocycline Caenorhabditis elegans 12   N2 200 µM Y 30479271
Minocycline Caenorhabditis elegans 43   N2 50 µM Y 30479271
Minocycline Caenorhabditis elegans 51   N2 100 µM Y 30479271
Minocycline Caenorhabditis elegans 10   N2 200 µM Y 30479271
Minocycline Caenorhabditis elegans 6   N2 50 µM Y 30479271
Minocycline Caenorhabditis elegans 30   N2 100 µM Y 30479271
Minocycline Caenorhabditis elegans 14   N2 200 µM Y 30479271
Minocycline Caenorhabditis elegans 33   N2 50 µM Y 30479271
Minocycline Caenorhabditis elegans 48   N2 100 µM Y 30479271
Minocycline Caenorhabditis elegans 30   N2 200 µM Y 30479271
ursolic acid Drosophila melanogaster 12.78   w1118 50 µmol/L Y 30496629
ethanol extract of Agrimonia procera herba Caenorhabditis elegans 8.1   N2 50 µg/mL Y 30558122
ethanol extract of Agrimonia procera herba Caenorhabditis elegans 12.7   N2 100 µg/mL Y 30558122
ethanol extract of Agrimonia procera herba Caenorhabditis elegans 7.5   N2 200 µg/mL Y 30558122
Paxilline Caenorhabditis elegans 26.62   N2 10 nM Y 30613772
Ellagic acid Caenorhabditis elegans -4.3   N2 50 µM N 27400265
Urolithin B Caenorhabditis elegans 36.6   N2 50 µM Y 27400265
Urolithin C Caenorhabditis elegans 36   N2 50 µM Y 27400265
Urolithin D Caenorhabditis elegans 19   N2 50 µM Y 27400265
Urolithin A Caenorhabditis elegans 45.4   N2 50 µM Y 27400265
Urolithin A Caenorhabditis elegans 40.7   N2 30 µM Y 27400265
Urolithin A Caenorhabditis elegans 24   N2 10 µM Y 27400265
Tanespimycin Caenorhabditis elegans 23.52   N2 100 µM Y 30625143
CGP37157 Caenorhabditis elegans 14.9   N2 50 µM Y 30705628
CGP37157 Caenorhabditis elegans 10.9   N2 100 µM Y 30705628
Quercetin Mus musculus -14.2   LACA 10 mg/day Y 7140862
Quercetin Mus musculus -11.6   LACA 10 mg/day Y 7140862
Reference: Jones E and Hughes RE (1982) Quercetin, flavonoids and the life-span of mice. Exp Gerontol