Overexpressed in senescence -1

Aging and Senescence

Entrez Id	Gene Symbol	Method	Senescence Type	Effect on senescence	Cell Types	Cell Lines	Cancer Line?
6714	SRC	Overexpression	Stress-induced	Inhibition	Fibrosarcoma	HT1080	Yes
604	BCL6	Overexpression	Replicative	Inhibition	B-cell	Primary cell	No
57332	CBX8	Overexpression	Replicative	Inhibition	Fibroblast	TIG-3	No
1019	CDK4	Overexpression	Replicative	Inhibition	Foreskin fibroblast	BJ	No
1021	CDK6	Overexpression	Replicative	Inhibition	Foreskin fibroblast	BJ	No
7913	DEK	Overexpression	Replicative	Inhibition	Foreskin keratinocyte	Primary cell	No
1746	DLX2	Overexpression	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90	No
2353	FOS	Overexpression	Replicative	Inhibition	Lung fibroblast	WI-38	No
3397	ID1	Overexpression	Replicative	Inhibition	Dermal endothelial, Umbilical vein endothelial	Primary cell	No
79923	NANOG	Overexpression	Replicative	Inhibition	Dermal fibroblast, Fibroblast	NIH3T3, Oct4-GiP	Yes
10783	NEK6	Overexpression	Replicative	Inhibition	Bladder cancer, Lung cancer	EJ, NCI-H1299	Yes
8493	PPM1D	Overexpression	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
27339	PRPF19	Overexpression	Replicative	Inhibition	Dermal fibroblast, Umbilical vein endothelial	Primary cell	No
5693	PSMB5	Overexpression	Replicative	Inhibition	Multipotent bone marrow stromal	Primary cell	No
6446	SGK1	Overexpression	Replicative	Inhibition	Umbilical vein endothelial	Primary cell	No
23411	SIRT1	Overexpression	Replicative	Inhibition	Lung fibroblast	2BS	No
7015	TERT	Overexpression	Replicative	Inhibition	Foreskin fibroblast, Retinal pigment epithelial	BJ, RPE-340	No
7114	TMSB4X	Overexpression	Replicative	Inhibition	Nucleus pulposus	Primary cell	No
7422	VEGFA	Overexpression	Replicative	Inhibition	Dermal endothelial	Primary cell	No
4101	MAGEA2	Overexpression	Oncogene-induced	Inhibition	Foreskin fibroblast	BJ	No
9759	HDAC4	Knockout, Overexpression	Replicative	Inhibition	Lung fibroblast	2BS	No
3309	HSPA5	Knockout, Overexpression	Stress-induced	Inhibition	Ovarian cancer	A2780	Yes
648	BMI1	Knockout, Overexpression	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast, Skin fibroblast	82-6, BJ, WI-38	No
672	BRCA1	Mutation	Stress-induced	Inhibition	Breast cancer	HBL100, HCC1937, MCF-7	Yes
47	ACLY	Knockout	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
472	ATM	Knockout	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, MRC-5, WI-38	No
84661	DPY30	Knockout	Replicative	Inhibition	Lung fibroblast	IMR-90	No
2539	G6PD	Knockout	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3768	KCNJ12	Knockout	Stress-induced	Inhibition	Breast cancer, Gastric cancer, Prostate cancer	DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47D	Yes
4609	MYC	Knockout	Oncogene-induced	Inhibition	Fibroblast	LF1	No
4780	NFE2L2	Knockout	Replicative	Inhibition	Lung fibroblast	HFL-1	No
5948	RBP2	Knockout	Replicative	Inhibition	Cervical cancer, Gastric cancer	AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa	Yes
6829	SUPT5H	Knockout	Oncogene-induced	Inhibition	Cervical cancer	HeLa	Yes
10460	TACC3	Knockout	Stress-induced	Inhibition	Breast cancer	MCF-7	Yes
7014	TERF2	Knockout	Replicative	Inhibition	Neuroblastoma	SH-SY5Y	Yes
7490	WT1	Knockout	Oncogene-induced	Inhibition	Lung cancer	NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727	Yes
7707	ZNF148	Knockout	Replicative	Inhibition	Lung cancer	NCI-H460	Yes
231	AKR1B1	Knockdown, Overexpression	Stress-induced	Inhibition	Keratinocyte	HaCat	Yes
23492	CBX7	Knockdown, Overexpression	Replicative	Inhibition	Keratinocyte, Lung fibroblast	Primary cell, WI-38	No
8087	FXR1	Knockdown, Overexpression	Replicative	Inhibition	Laryngeal cancer, Tongue cancer	CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B	Yes
55355	HJURP	Knockdown, Overexpression	Replicative	Inhibition	Dermal fibroblast, Umbilical vein endothelial	Primary cell	No
3316	HSPB2	Knockdown, Overexpression	Stress-induced	Inhibition	Breast epithelial	MCF-10A, MCF-7	No
3489	IGFBP6	Knockdown, Overexpression	Replicative	Inhibition	Fibroblast	Primary cell	No
4170	MCL1	Knockdown, Overexpression	Stress-induced	Inhibition	Colon cancer	HCT116	Yes
59277	NTN4	Knockdown, Overexpression	Stress-induced	Inhibition	Glioma	T98G, U-251MG, U-87MG, U-U118MG	Yes
23598	PATZ1	Knockdown, Overexpression	Replicative	Inhibition	Umbilical vein endothelial	Primary cell	No
11059	WWP1	Knockdown, Overexpression	Replicative	Inhibition	Lung fibroblast	2BS, WI-38	No
444	ASPH	Knockdown	Replicative	Inhibition	Liver cancer	FOCUS, HepG2, Huh7	Yes
55729	ATF7IP	Knockdown	Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
6790	AURKA	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
9531	BAG3	Knockdown	Replicative	Inhibition	Glioma, Laryngeal cancer	A172, HEp2	Yes
644	BLVRA	Knockdown	Stress-induced	Inhibition	Fibroblast	Primary cell	No
10950	BTG3	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90, WI-38	No
983	CDK1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
8099	CDK2AP1	Knockdown	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
1058	CENPA	Knockdown	Replicative	Inhibition	Lung fibroblast	TIG-3	No
1452	CSNK1A1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
1457	CSNK2A1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
8727	CTNNAL1	Knockdown	Replicative	Inhibition	Lung cancer, Squamous carcinoma	A549, OC2	Yes
54487	DGCR8	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
1660	DHX9	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5	No
80824	DUSP16	Knockdown	Replicative	Inhibition	Embryonic kidney, Liver cancer	HEK293FT, HepG2, PLC/PRF/5	Yes
1845	DUSP3	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
2021	ENDOG	Knockdown	Replicative	Inhibition	Endothelial	Primary cell	No
2042	EPHA3	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
2146	EZH2	Knockdown	Stress-induced	Inhibition	Gastric cancer	SGC-7901	Yes
2305	FOXM1	Knockdown	Replicative	Inhibition	Gallbladder cancer	GBC-SD	Yes
2309	FOXO3	Knockdown	Replicative	Inhibition	Dermal fibroblast	Primary cell	No
2597	GAPDH	Knockdown	Replicative	Inhibition	Lung cancer	A549	Yes
2720	GLB1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3096	HIVEP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
3146	HMGB1	Knockdown	Replicative	Inhibition	Lung cancer, Melanoma	A375, G361, NCI-H1299, SK-MEL-28	Yes
10765	KDM5B	Knockdown	Replicative	Inhibition	Colon cancer	Colo201, DLD1, HCT116	Yes
57650	KIAA1524	Knockdown	Replicative	Inhibition	Gastric cancer	AGS, BGC-823, HGC-27, KATO-III	Yes
9365	KL	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5, WI-38	No
9113	LATS1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
3958	LGALS3	Knockdown	Replicative	Inhibition	Gastric cancer	AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2	Yes
51474	LIMA1	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
4085	MAD2L1	Knockdown	Replicative	Inhibition	Breast epithelial, Lung fibroblast	IMR-90, MCF-10A	No
4116	MAGOH	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
55110	MAGOHB	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
5606	MAP2K3	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
11184	MAP4K1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
54708	5-Mar	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
4190	MDH1	Knockdown	Replicative	Inhibition	Dermal fibroblast, Lung fibroblast	IMR-90, Primary cell	No
4204	MECP2	Knockdown	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
4318	MMP9	Knockdown	Replicative	Inhibition	Medulloblastoma	DAOY	Yes
4638	MYLK	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
4750	NEK1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
64175	P3H1	Knockdown	Replicative, Stress-induced	Inhibition	Lung fibroblast	IMR-90	No
25913	POT1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
5495	PPM1B	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
55170	PRMT6	Knockdown	Replicative	Inhibition	Breast cancer, Breast epithelial	MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3	Yes
10213	PSMD14	Knockdown	Replicative	Inhibition	Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer	A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75	Yes
5885	RAD21	Knockdown	Replicative	Inhibition	Breast cancer	MDA-MB-231	No
9978	RBX1	Knockdown	Replicative	Inhibition	Glioblastoma, Lung cancer	U87	Yes
10856	RUVBL2	Knockdown	Replicative	Inhibition	Kidney cancer	A498, KRC/Y	Yes
280636	SELENOH	Knockdown	Replicative	Inhibition	Lung fibroblast	MRC-5	No
29843	SENP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
59343	SENP2	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
57337	SENP7	Knockdown	Replicative	Inhibition	Foreskin fibroblast	Primary cell	No
51548	SIRT6	Knockdown	Replicative	Inhibition	Chondrocyte	NHAC-kn	No
6495	SIX1	Knockdown	Replicative	Inhibition	Lung fibroblast	IMR-90	No
9194	SLC16A7	Knockdown	Replicative	Inhibition	Colon cancer, Gastric cancer	DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480	Yes
6597	SMARCA4	Knockdown	Replicative	Inhibition	Mesenchymal stem	Primary cell	No
23049	SMG1	Knockdown	Replicative	Inhibition	Embryonic kidney, Retinal pigment epithelial	HEK293T, hTERT-RPE1	Yes
6615	SNAI1	Knockdown	Replicative	Inhibition	Prostate cancer	LNCaP, PC-3	Yes
6647	SOD1	Knockdown	Replicative	Inhibition	Lung fibroblast	WI-38, WI38-SV40	No
6909	TBX2	Knockdown	Replicative	Inhibition	Melanoma	B16	Yes
7012	TERC	Knockdown	Replicative	Inhibition	Cervical cancer	HeLa	Yes
7027	TFDP1	Knockdown	Replicative	Inhibition	Cervical cancer, Lung cancer, Lung fibroblast	A549, HeLa, WI-38	Yes
8741	TNFSF13	Knockdown	Replicative	Inhibition	Colon cancer	SW480	Yes
7175	TPR	Knockdown	Replicative	Inhibition	Cervical cancer, Melanoma, Osteosarcoma	A375, HeLa, U2OS	Yes
79054	TRPM8	Knockdown	Replicative	Inhibition	Pancreatic cancer	BxPC-3, PANC-1	Yes
7295	TXN	Knockdown	Replicative	Inhibition	Foreskin fibroblast	BJ, BJE-LT	No
7398	USP1	Knockdown	Oncogene-induced	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, WI-38	No
7472	WNT2	Knockdown	Replicative	Inhibition	Lung fibroblast	WI-38	No
7486	WRN	Knockdown	Oncogene-induced	Inhibition	Fibroblast, WRN syndrome fibroblast	AG00780, AG03141	Yes
10413	YAP1	Knockdown	Replicative	Inhibition	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90, WI-38	No
64393	ZMAT3	Knockdown	Replicative	Inhibition	Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma	HEK293T, MCF-7, U2OS	Yes
3400	ID4	Overexpression	Stress-induced	Induction	Prostate cancer	DU145	Yes
5824	PEX19	Overexpression	Stress-induced	Induction	Osteosarcoma	U2OS	Yes
8553	BHLHE40	Overexpression	Replicative, Stress-induced	Induction	Breast cancer, Esophageal cancer	EC9706, MCF-7	Yes
7157	TP53	Overexpression	Replicative, Stress-induced	Induction	Bladder cancer	EJ	Yes
80019	UBTD1	Overexpression	Replicative, Stress-induced	Induction	Breast cancer, Colorectal cancer, Gastric cancer, Gastric epithelial, Lung fibroblast, Prostate cancer	AGS, GES-1, KATO-III, LoVo, MCF-7, MKN28, MKN45, MRC-5, NCI-N87, PC-3, SGC-7901, SNU-1, SNU-16	Yes
51225	ABI3	Overexpression	Replicative	Induction	Colon cancer, Thyroid cancer	ARO, WRO	Yes
203054	ADCK5	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
247	ALOX15B	Overexpression	Replicative	Induction	Prostate epithelial	Primary cell	No
10095	ARPC1B	Overexpression	Replicative	Induction	Osteosarcoma	SaOs-2	Yes
558	AXL	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
640	BLK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
595	CCND1	Overexpression	Replicative	Induction	Fibroblast	Hs68, WI-38	No
5129	CDK18	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
1027	CDKN1B	Overexpression	Replicative	Induction	Lung fibroblast	TIG-3	No
1028	CDKN1C	Overexpression	Replicative	Induction	Liver cancer	HepG2, SNU-398	Yes
1029	CDKN2A	Overexpression	Replicative	Induction	Lung fibroblast	TIG-3	No
55602	CDKN2AIP	Overexpression	Replicative	Induction	Lung fibroblast	MRC-5, TIG-1	No
1030	CDKN2B	Overexpression	Replicative	Induction	Glioblastoma	T98G, U-251MG, U-373MG	Yes
1152	CKB	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
3576	CXCL8	Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90, WI-38	No
3491	CYR61	Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90	No
1869	E2F1	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
26298	EHF	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
54206	ERRFI1	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
10922	FASTK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
79791	FBXO31	Overexpression	Replicative	Induction	Breast cancer	MCF-7	Yes
56287	GKN1	Overexpression	Replicative	Induction	Gastric cancer	AGS, MKN1	Yes
2870	GRK6	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
3065	HDAC1	Overexpression	Replicative	Induction	Cervical cancer	HeLa	Yes
220296	HEPACAM	Overexpression	Replicative	Induction	Breast cancer	MCF-7	Yes
3101	HK3	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
3458	IFNG	Overexpression	Replicative	Induction	Umbilical vein endothelial	Primary cell	No
3484	IGFBP1	Overexpression	Replicative	Induction	Breast cancer	MCF-7	Yes
3621	ING1	Overexpression	Replicative	Induction	Foreskin fibroblast	Hs68	No
3661	IRF3	Overexpression	Replicative	Induction	Foreskin fibroblast	BJ	No
3663	IRF5	Overexpression	Replicative	Induction	Li Fraumeni syndrome fibroblast	MDAH041	Yes
3665	IRF7	Overexpression	Replicative	Induction	Li Fraumeni syndrome fibroblast	MDAH041	Yes
3705	ITPK1	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
3707	ITPKB	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
3984	LIMK1	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
5604	MAP2K1	Overexpression	Replicative	Induction	Intestinal epithelial	HIEC-6	No
5608	MAP2K6	Overexpression	Replicative	Induction	Osteosarcoma	U2OS	Yes
5609	MAP2K7	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
9064	MAP3K6	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
6885	MAP3K7	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
6300	MAPK12	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
22983	MAST1	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
4145	MATK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
10445	MCRS1	Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast, Mammary epithelial	H184B5F5/M10, Hs68, IMR-90	No
126308	MOB3A	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
23515	MORC3	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
10934	MORF4	Overexpression	Replicative	Induction	Fibrosarcoma	A9, HT1080	Yes
4598	MVK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
10608	MXD4	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
65220	NADK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
4814	NINJ1	Overexpression	Replicative	Induction	Hepatoma	Huh7	Yes
5015	OTX2	Overexpression	Replicative	Induction	Medulloblastoma	D283, D341, D425, D458, D556, DAOY, MED8A, UW228-2	Yes
10298	PAK4	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
149420	PDIK1L	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
5170	PDPK1	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
23037	PDZD2	Overexpression	Replicative	Induction	Breast cancer, Liver cancer, Prostate cancer	DU145	Yes
51588	PIAS4	Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
23533	PIK3R5	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
5315	PKM	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
10654	PMVK	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
87178	PNPT1	Overexpression	Replicative	Induction	Melanoma	FO-1, HO-1, MeWo	Yes
5460	POU5F1	Overexpression	Replicative	Induction	Mesenchymal stromal	Primary cell	No
5629	PROX1	Overexpression	Replicative	Induction	Liver cancer	Hep3B, HepG2, Mahlavu, SK-HEP1	Yes
9232	PTTG1	Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90, WI-38	No
861	RUNX1	Overexpression	Replicative	Induction	Foreskin fibroblast	Hs68	No
150094	SIK1	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
64849	SLC13A3	Overexpression	Replicative	Induction	Lung fibroblast, Renal tubular	MRC-5, WI-38	No
6598	SMARCB1	Overexpression	Replicative	Induction	Malignant rhabdoid tumor	G-401	Yes
64750	SMURF2	Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast, Skin fibroblast	BJ, WI-38, WS1	No
8470	SORBS2	Overexpression	Replicative	Induction	Fibroblast, Keratinocyte	Primary cell	No
6657	SOX2	Overexpression	Replicative	Induction	Colon cancer, Embryonic kidney	HCT116, HEK293T, WiDr	Yes
6667	SP1	Overexpression	Replicative	Induction	Lung fibroblast	2BS	No
10927	SPIN1	Overexpression	Replicative	Induction	Cervical cancer	HeLa	Yes
6720	SREBF1	Overexpression	Replicative	Induction	Fibroblast	Primary cell	No
6777	STAT5B	Overexpression	Replicative	Induction	Lung fibroblast	IMR-90	No
282974	STK32C	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
83931	STK40	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
6850	SYK	Overexpression	Replicative	Induction	Melanoma	501-mel, A375, SK-MEL-28	Yes
7023	TFAP4	Overexpression	Replicative	Induction	Breast cancer, Retinal pigment epithelial	hTERT-RPE, MCF-7	Yes
7098	TLR3	Overexpression	Replicative	Induction	Fibroblast, Keratinocyte	Primary cell	No
7297	TYK2	Overexpression	Replicative	Induction	Embryonic kidney, Lung fibroblast	HEK293T, IMR-90, MRC-5	No
7538	ZFP36	Overexpression	Replicative	Induction	Cervical cancer	HeLa	Yes
207	AKT1	Overexpression	Oncogene-induced	Induction	Aortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelial	Primary cell	No
673	BRAF	Overexpression	Oncogene-induced	Induction	Foreskin fibroblast, Melanocyte	BJ, Primary cell	No
2919	CXCL1	Overexpression	Oncogene-induced	Induction	Ovarian fibroblast	Gro-1	No
2113	ETS1	Overexpression	Oncogene-induced	Induction	Foreskin fibroblast, Lung fibroblast	Hs68, TIG-3	No
2114	ETS2	Overexpression	Oncogene-induced	Induction	Foreskin fibroblast, Lung fibroblast	Hs68, TIG-3	No
3265	HRAS	Overexpression	Oncogene-induced	Induction	Lung fibroblast	IMR-90, WI-38	No
5605	MAP2K2	Overexpression	Oncogene-induced	Induction	Lung fibroblast	IMR-90	No
5371	PML	Overexpression	Oncogene-induced	Induction	Lung fibroblast	WI-38	No
5894	RAF1	Overexpression	Oncogene-induced	Induction	Lung fibroblast	IMR-90	No
2810	SFN	Overexpression	Oncogene-induced	Induction	Melanoma	SK-MEL-147, SK-MEL-19, SK-MEL-29	Yes
6660	SOX5	Overexpression	Oncogene-induced	Induction	Glioma	U-1242MG, U-178MG, U-251MG, U-343MG, U-343MGa	Yes
6426	SRSF1	Overexpression	Oncogene-induced	Induction	Foreskin fibroblast	BJ	No
1718	DHCR24	Mutation	Oncogene-induced	Induction	Lung fibroblast	WI-38	No
183	AGT	Knockout, Overexpression	Replicative	Induction	Vascular smooth muscle	Primary cell	No
25842	ASF1A	Knockout, Overexpression	Oncogene-induced, Replicative	Induction	Lung fibroblast	Primary cell	No
64506	CPEB1	Knockout, Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast	Primary cell, WI-38	No
2791	GNG11	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	TIG-7	No
3488	IGFBP5	Knockout, Overexpression	Replicative	Induction	Umbilical vein endothelial	Primary cell	No
3622	ING2	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	MRC-5	No
9891	NUAK1	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
7703	PCGF2	Knockout, Overexpression	Replicative	Induction	Foreskin fibroblast, Lung fibroblast	BJ, MRC-5, WI-38	No
22925	PLA2R1	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	IMR-90, WI-38	No
6041	RNASEL	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	WI-38	No
26156	RSL1D1	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	2BS	No
23309	SIN3B	Knockout, Overexpression	Replicative	Induction	Lung fibroblast	IMR-90	No
7041	TGFB1I1	Knockout, Overexpression	Replicative	Induction	Fibroblast	KMST-6, SUSM-1	No
9966	TNFSF15	Knockout, Overexpression	Replicative	Induction	Endothelial progenitor	Primary cell	No
10628	TXNIP	Knockout, Overexpression	Oncogene-induced, Replicative	Induction	Lung fibroblast	2BS	No
1026	CDKN1A	Knockout	Replicative	Induction	Fibroblast	LF1	No
1111	CHEK1	Knockout	Stress-induced	Induction	Colon cancer	HCT116	Yes
1643	DDB2	Knockout	Oncogene-induced	Induction	Lung fibroblast	IMR-90	No
2130	EWSR1	Knockout	Replicative	Induction	Hematopoietic stem	Primary cell	No
3552	IL1A	Knockout	Replicative	Induction	Umbilical vein endothelial	Primary cell	No
1432	MAPK14	Knockout	Replicative, Stress-induced	Induction	Lung fibroblast	MRC-5, WI-38	No
8550	MAPKAPK5	Knockout	Oncogene-induced	Induction	Foreskin fibroblast	BJ	No
11235	PDCD10	Knockout	Oncogene-induced, Replicative	Induction	Coronary artery endothelial, Lung fibroblast	IMR-90, Primary cell	No
7150	TOP1	Knockout	Replicative	Induction	Lung fibroblast	IMR-90, WI-38	No
8626	TP63	Knockout	Replicative	Induction	Foreskin fibroblast	BJ	No
10155	TRIM28	Knockout	Oncogene-induced	Induction	Lung fibroblast	IMR-90	No
367	AR	Knockdown, Overexpression	Replicative	Induction	Hair follicular keratinocyte	Primary cell	No
284119	CAVIN1	Knockdown, Overexpression	Replicative	Induction	Cervical cancer, Lung fibroblast	HeLa, IMR-90, WI-38	No
1051	CEBPB	Knockdown, Overexpression	Stress-induced	Induction	Prostate cancer	LNCaP	Yes
2626	GATA4	Knockdown, Overexpression	Replicative, Stress-induced	Induction	Foreskin fibroblast, Lung fibroblast	BJ, IMR-90	No
50618	ITSN2	Knockdown, Overexpression	Stress-induced	Induction	Foreskin fibroblast, Lung fibroblast	Hs68, WI-38	No
50507	NOX4	Knockdown, Overexpression	Replicative	Induction	Breast epithelial, Lung fibroblast	MCF-12A, TIG-3	No
5037	PEBP1	Knockdown, Overexpression	Stress-induced	Induction	Colon cancer, Gastric cancer, Lung cancer, Prostate cancer	A549, HCT116, MKN45, PC-3	Yes
5292	PIM1	Knockdown, Overexpression	Oncogene-induced, Replicative	Induction	Foreskin fibroblast, Lung fibroblast	2BS, BJ, WI-38	No
5580	PRKCD	Knockdown, Overexpression	Replicative	Induction	Lung fibroblast	TIG-1	No
5583	PRKCH	Knockdown, Overexpression	Stress-induced	Induction	Breast cancer	MCF-7	Yes
27330	RPS6KA6	Knockdown, Overexpression	Replicative	Induction	Colon cancer, Lung fibroblast	IMR-90	No
8651	SOCS1	Knockdown, Overexpression	Oncogene-induced, Replicative	Induction	Lung fibroblast	IMR-90	No
8405	SPOP	Knockdown, Overexpression	Replicative	Induction	Lung fibroblast	IMR-90	No
27287	VENTX	Knockdown, Overexpression	Replicative	Induction	Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma	HEK293T, HeLa, IMR-90, Nalm16, U2OS	Yes
54739	XAF1	Knockdown, Overexpression	Stress-induced	Induction	Dermal microvascular endothelial cells	Primary cell	No
83719	YPEL3	Knockdown, Overexpression	Stress-induced	Induction	Breast cancer	MCF-7	Yes
29117	BRD7	Knockdown	Replicative	Induction	Foreskin fibroblast	BJ	No
857	CAV1	Knockdown	Replicative	Induction	Fibroblast	Primary cell	No
3486	IGFBP3	Knockdown	Stress-induced	Induction	Lung fibroblast	WI-38	No
3691	ITGB4	Knockdown	Replicative	Induction	Umbilical vein endothelial	Primary cell	No
10397	NDRG1	Knockdown	Replicative	Induction	Liver cancer	Hep3B, HepG2, Huh7, PLC/PRF/5	Yes
6787	NEK4	Knockdown	Replicative, Stress-induced	Induction	Foreskin fibroblast	BJ	No
4854	NOTCH3	Knockdown	Stress-induced	Induction	Breast cancer, Fibroblast, Foreskin fibroblast, Glioma, Melanoma	A375P, BJ, LF1, MDA-MB-231, T98G, WS1	Yes
55193	PBRM1	Knockdown	Replicative	Induction	Foreskin fibroblast	BJ	No
5925	RB1	Knockdown	Stress-induced	Induction	Osteoblast	Primary cell	No
5054	SERPINE1	Knockdown	Replicative	Induction	Foreskin fibroblast	BJ, Primary cell	No
51384	WNT16	Knockdown	Replicative	Induction	Lung fibroblast	MRC-5	No
Reference: HAGR