Gene Expressions and Target Genes


Aging and Senescence

     NFkappaB target genes
Acute Phase Proteins
Human Gene Name Gene Function Acc # References
AGT Angiotensinogen (Angiotensin II) Angiotensin precursor, regulates blood pressure NM_000029 Brasier et al, 1990; Ron et al, 1990
C4A Complement factor C4 Activates extrinsic pathway of complement activation NM_007293 Yu et al, 1989
C4BPA C4b binding protein Complement binding protein NM_000715 Moffat & Tack, 1992
CFB Complement factor B Complement factor NM_001710 Nonaka & Huang, 1990
CRP C-reactive protein Host defense protein NM_000567 Zhang et al, 1995; Agrawal et al, 2003a
Agrawal et al, 2003b
DEFB2 beta-defensin-2 Anti-microbial peptide AF040153 Diamond et al, 2000; Tsutsumi-Ishii & Nagaoka, 2002; Kao et al, 2008
F3 Tissue factor-1 Activates extrinsic pathway of complement activation NM_001993 Mackman et al, 1991
HAMP Hepcidin Acute phase protein NM_021175 Liao et al, 2006
LBP Lipopolysaccharide binding protein Binds to LPS receptor (CD14) with LPS NM_004139 Schumann, 1995
PLAU Urokinase-type plasminogen activator Activates fibrinogen for fibrin clot lysis NM_002658 Novak et al, 1991
PTX3 Pentraxin PTX3 Pentraxin NM_002852 Basile et al, 1997
SAA1 Serum amyloid A proteins (SAA1, SAA2, SAA3) Serum components NM_000331 Edbrooke et al, 1991; Li & Liao, 1991; Thorn & Whitehead, 2002; Son et al, 2004
SAA2 Serum amyloid A proteins (SAA1, SAA2, SAA3) Serum components NM_030754  
SAA3 Serum amyloid A proteins (SAA1, SAA2, SAA3) Serum components S73444  
Apoptosis regulators
Human Gene Name Gene Function Acc # References
  Nr13 Pro-survival Bcl-2 homologue   Lee et al, 1999
  IAPs Inhibitors of Apoptosis   You et al, 1997; Stehlik et al, 1998a, 1998b
BAX Bax Pro-apoptotic Bcl-2 homologue NM_004324 Grimm et al, 2004
BCL2 Bcl-2 Pro-survival factor NM_000633 Catz & Johnson, 2001
BCL2A1 Bfl1/A1 Pro-survival Bcl-2 homologue NM_004049 Grumont et al, 1999; Zong et al, 1999
BCL2L1 Bcl-xL Pro-survival Bcl-2 homologue NM_138578 Chen et al, 1999; Lee et al, 1999
BCL2L11 Bim Pro-apoptotic Bcl-2 homolog NM_138621 Wang et al, 2008
BNIP3 BNIP3 Hypoxia-inducible death factor NM_004052 Baetz et al, 2005; Shaw et al, 2006
CASP4 Caspase-11 Caspase NM_001225 Schauvliege et al, 2002
CD274 B7-H1 Programmed cell death ligand 1 NM_014143 Lee et al, 2005
CFLAR c-FLIP Pro-survival factor NM_003879 Kreuz et al, 2001
CIDEA CIDEA Cell death-inducing DFFA-like effector A NP_001270.1; NP_938031.1 Pettersson et al, 2008
FAS CD95 (Fas) Pro-apoptotic receptor NM_000043 Chan et al, 1999; Zhou et al, 2005; Singh et al, 2006
FASLG Fas-Ligand Inducer of apoptosis NM_000639 Matsui et al, 1998; Singh et al, 2006
IER3 IEX-1L Immediate early Gene NM_052815 Wu et al, 1998
PTPN13 *Fas-associated phosphatase-1 Protein phosphatase NM_006264 Irie et al, 2001
PYCARD ASC Apoptosis-associated speck-like protein containing a CARD NM_013258 Sun et al, 2007
TIFA *TRAF-2 binding protein (Carp) TRAF2 binding protein NM_052864 Chang et al, 2005
TRAF1 TRAF-1 TNF-receptor associated factor NM_005658 Schwenzer et al, 1999
TRAF2 TRAF-2 TNF-receptor associated factor NM_021138 Wang et al, 1998
XIAP XIAP X-linked inhibitor of apoptosis NM_001167 Turner et al, 2007
Cell adhesion molecules
Human Gene Name Gene Function Acc # References
CD209 DC-SIGN Dendritic cell surface C-type lectin NM_021155 Liu et al, 2003
CD44 CD44 Cell-surface receptor for hyaluronic acid NP_000601 Hinz et al, 2002
CD54 ICAM-1 Intercellular adhesion molecule-1 NM_000201 van de Stolpe et al., 1994; Bunting et al, 2007
ENG Endoglin Endothelial cell membrane glycoprotein NM_000118 Botella et al, 2002
FN1 Fibronectin Extracellular attachment NM_002026 Lee et al, 2002; Norton et al, 2004
MADCAM1 MadCAM-1 Mucosal addressin cell adhesion molecule NM_130760 Takeuchi & Baichwal, 1995
NCAM NCAM Neural cell adhesion molecule NM_000615 Simpson & Morris, 2000
SELE ELAM-1 (CD62E, E-selectin) E-selectin, endothelial cell leukocyte adhesion molecule NM_000450 Whelan et al, 1991; Schindler & Baichwal, 1994
SELP P-selectin Platelet adhesion receptor NM_003005 Pan & McEver, 1995
TNC Tenascin-C ECM protein controls cell attachment and migration, cell growth NM_002160 Mettouchi et al, 1997
VCAM1 VCAM-1 Vascular cell adhesion molecule NM_001078 Iademarco et al, 1992
Cell-surface receptors
Human Gene Name Gene Function Acc # References
ABCA1 ABCA1 ATP-binding cassette transporter NM_005502 Gerbod-Giannone et al, 2006
ABCB1 P-gp P-glycoprotein-Drug resistance NM_000927 Wang et al, 2007
ABCB4 Mdr1 Multiple drug resistance mediator (P-glycoprotein) NM_018849 Zhou & Kuo, 1997; Wang et al, 2007
ABCC6 ABCC6 ATP-binding, multidrug resistance-associated protein 6 transporter NM_001171 Jiang et al, 2005
ADAM19 *ADAM19 Dendritic cell marker NM_023038 Ehrnsperger et al, 2005
ADORA1 A1 adenosine receptor Pleiotropic physiological effects NM_000674 Nie et al, 1998; Jhaveri et al, 2007
ADORA2A A2A Adenosine receptor NM_000675 Morello et al, 2006
ADRA2B *alpha2B-adrenergic receptor adrenergic receptor NM_000682 Cayla et al, 2004
AGER RAGE- receptor for advanced glycation end products Receptor for Advanced Glycation End products NM_001136 Li & Schmidt, 1997
BDKRB1 Bradykinin B1-Receptor Pleiotropic physiological effects NM_000710 Ni et al, 1998
C69 CD69 Lectin mainly on activated T cells NM_001781 Lopez-Cabrera et al, 1995
EGFR Epidermal Growth Factor Receptor Receptor for EGF NM_005228 Nishi et al, 2003; Thornburg & Raab-Traub, 2007
ERBB2 ErbB2 EGF-like receptor NM_001005862 Kitamura et al, 2005
FCER2/CD23 *CD23 Cell-surface molecule NM_002002 Tinnell et al, 1998
GRIN1 *NMDA receptor subunit NR-1 (GRIN1 Gene) Subunit of neural receptor for N-methyl-D-aspartate NM_021569 Begni et al, 2003
GRIN2A *NMDA receptor subunit 2A (rat) Neural receptor for N-methyl-D-aspartate NM_000833 Richter et al, 2002
GRM2 mGlu2 Metabotropic glutamate receptor 2 NM_000839 Chiechio et al, 2006
KISS1 Gal1 Receptor Galanin receptor, neuroendocrine peptide NM_002256 Lorimer et al, 1997
KLRA1 Ly49 Receptor on NK cells NM_006611 Pascal et al, 2007
NPY1R Neuropeptide Y-Y1 receptor Pleiotropic physiological effects NM_000909 Musso et al, 1997
OLR1 Lox-1 Receptor for Oxidized low density lipoprotein NM_002543 Nagase et al, 1998
OPRD1 DOR Delta opiod receptor NM_000911 Chen et al, 2005, 2006
OPRM1 Mu-opioid receptor Opioid Receptor EU360599 Kraus et al, 2003
OXTR Oxytocin receptor Oxytocin receptor NM_000916 Terizidou et al, 2006
PTAFR PAF receptor 1 Platelet activator receptor NM_000952 Mutoh et al, 1994
SCNN1A Amiloride-sensitive sodium channel Sodium channel NM_001038 Baines et al, 2002; Haddad, 2005
Cytokines/Chemokines and their modulators
Human Gene Name Gene Function Acc # References
BLIMP1 /PRDM1 BLIMP-1 B lymphocyte-induced maturation protein-1 NM_00198 Calame, 2008
CCL1 TCA3, T-cell activation Gene 3 T-cell activation Gene 3, beta chemokine NM_002981 Oh & Metcalfe, 1994
CCL15 CCL15/Leukotactin/ SCYA15 Chemokine for cell attraction NM_032965 Shin et al, 2005
CCL17 CCL17 Chemokine NM_002987 Takegawa et al, 2008
CCL19 CCL19 Recruitment of naive T cells to dendritic cells NM_006274 Pietila et al, 2007
CCL2 MCP-1/JE Macrophage chemotactic protein, beta Chemokine NM_002982 Ueda et al, 1994; Ueda et al, 1997 Teferedegne et al, 2006; Xing & Remick, 2007; Ishikado et al, 2009
CCL20 CCL20 Ligand of CC chemokine receptor 6 NM_004591 Lee et al, 2008; Battaglia et al, 2007
CCL20 MIP-3alpha/CCL20 Macrophage inflammatory protein-3a NM_004591 Kwon et al, 2002; Tomimori et al, 2007
CCL22 CCL22 Epithelial cell chemokine at mucosa NM_002990 Nakayama et al, 2004
CCL23 CCL23/SYA23 Monocyte chemokine NM_005064 Shin et al, 2007
CCL28 CCL28 Chemokine for T-cell attraction NM_148672 Ogawa et al, 2004
CCL3 MIP-1a,b Macrophage inflammatory protein-1, b Chemokine NM_002983 Grove & Plumb, 1993; Widmer et al, 1993
CCL4     NM_002984  
CCL4 aka (LAG-1) Lymphocyte activation Gene-1 NM_002984 Xu et al, 2002; Modi et al, 2001
CCL5 CCL5 T-cell secreted factor NM_002985 Wickremasinghe et al, 2004
CCL5 RANTES Regulated upon Activation Normal T lymphocyte Expressed and Secreted,b Chemokine NM_002985 Moriuchi et al, 1997
CXCL1 CINC-1 Cytokine-induced neutrophil chemoattractant NM_001511 Blackwell et al, 1994 Ohtsuka et al, 1996
CXCL1 Gro alpha Melanoma growth stimulating activity NM_001511 Anisowicz et al, 1991
CXCL1 Gro-1 Growth regulated oncogene; chemokine NM_001511 Wood, 1995
CXCL10 Eotaxin beta Chemokine, eosinphil-specific NM_001565. Hein et al, 1997
CXCL10 *mob-1 A C-X-C chemokine NM_001565 Varley et al, 2003
CXCL11 *CXCL 11 Chemokine ligand for CXCR3 NM_005409 Tensen et al, 1999
CXCL3 Fractalkine TNF-induced chemokine NP_002987 Ahn et al, 2004;Bhavsar et al, 2008
CXCL3 MIP-2 Macrophage inflammatory protein-2, b Chemokine NM_002090 Widmer et al, 1993; Lee et al, 2005
CXCL5 IP-10 alpha Chemokine NM_002994 Ohmori & Hamilton, 1993; Yang et al, 2007
CXCL5     NM_002994  
CXCL5 Neutrophil activating peptide-78 Activates neutrophils NM_002994 Keates et al., 2001
CXCL6 *LIX (mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human) LPS-induced CXC chemokines NM_002993 Smith et al, 2002
CXCL9 MIG Monokine induced by IFN-gamma NM_002416 Bunting et al, 2007
EBI3 EBI3/IL-27B EBV-induced Gene 3 (IL-27beta chain) NM_005755 Poleganov et al, 2008
GRO-beta Gro beta Chemokine AAP13104 Anisowicz et al, 1991
GRO-gamma Gro gamma Chemokine AAP13105. Anisowicz et al, 1991
ICOS *ICOS Inducible co-stimulator NM_012092 Haaning Anderson et al, 2003
IFNB1 beta-Interferon Interferon NM_002176 Hiscott et al, 1989; Lenardo et al, 1989
IFNG IFN-g Interferon NM_000619 Sica et al, 1992; Sica et al, 1997
Iigp1 IiGp1 Cytokine NM_021792 Bunting et al, 2007
IL10 IL-10 Interleukin-10 NM_000572 Xu & Shu, 2002; Cao et al, 2006
IL11 IL-11 Interleukin-11 NM_000641 Bitko et al, 1997
IL12A IL-12A (p35) Interleukin-12 NM_000882 Homma et al, 2007
IL12B IL-12B (p40) Interleukin-12 NM_002187 Murphy et al, 1995
IL13 IL-13 Interleukin-13 NM_002188 Hinz et al, 2002
IL15 *IL-15 Interleukin-15 NM_172174 Azimi et al, 1998
IL17 IL-17 Interleukin-17 NM_002190 Shen et al, 2006
IL1A IL-1a Interleukin-1a NM_000575 Mori & Prager, 1996
IL1B IL-1b Interleukin-1b NM_000576 Hiscott et al, 1993
IL1RN IL-1 receptor antagonist Inhibitor of IL-1 activity NM_173842 Smith et al, 1994
IL2 IL-2 Interleukin-2 NM_000586 Serfling et al, 1989; Hoyos et al, 1989; Lai et al, 1995
IL23A IL-23A (p19) Interleukin-23 (p19 Gene) NM_016584 Carmody et al, 2006; Liu et al, 2007
IL27 IL-27 (p28) Interleukin-27 (p28 subunit) NM_145659 Liu et al, 2007
IL6 IL-6 Interleukin-6, inflammatory cytokine NM_000600 Libermann & Baltimore, 1990; Shimizu et al, 1990;Son et al, 2008
IL8 IL-8 Interleukin-8, alpha-chemokine NM_000584 Kunsch & Rosen, 1993; Kang et al., 2007
IL9 IL-9 Interleukin-9 NM_000590 Zhu et al, 1996; Chen et al, 2008
KC KC alpha Chemokine S79767 Ohmori et al, 1995
LTA Lymphotoxin a TNF-like cytokine NM_000595 Worm et al, 1998
LTA TNFbeta Tumor necrosis factor beta NM_000595 Paul et al, 1990; Messer et al, 1990
LTB Lymphotoxin b Anchors TNF to cell surface NM_002341 Kuprash et al, 1996
TFF3 TFF3 (Treefoil factor) Peptide in response to gut irritation NM_003226 Baus-Loncar et al, 2004
TNF TNFalpha Tumor necrosis factor alpha NM_000594 Shakhov et al, 1990; Collart et al, 1990
TNFSF10 TRAIL (aka Apo2 ligand) Cytokine NM_003810 Baetu et al, 2001; Matsuda et al, 2005
TNFSF13B BAFF B-cell Activating Factor NM_006573 Moon & Park , 2007
TNFSF15 VEGI Vascular endothelial growth inhibitor NM_005118 Xiao et al, 2005
Early response Genes
Human Gene Name Gene Function Acc # References
DCTN4 *p62 Non-proteasomal multi-ubiquitin chain binding protein NM_016221 Vadlamudi & Shin, 1998
EGR1 *Egr-1 Mitogen-induced early response Gene; zinc finger NM_001964 Zhou et al, 2003
IER3 p22/PRG1 Rat homologue of IEX NM_052815 Schafer et al, 1998
KLF10 *TIEG TGF-b early response Gene; zinc finger protein NM_001032282 Zhou et al, 2003
TNFAIP2 *B94 Early response Gene NM_006291 Zhou et al, 2003
Enzymes
Human Gene Name Gene Function Acc # References
ABCB9 *ABC Transporters ATP-binding membrane transporters NM_019625 Mutch et al, 2003
ADH1A ADH Liver alcohol dehydrogenase NM_000667 Potter et al, 2002
AICDA AID Activation-induced cytidine deaminase NM_020661 Gourzi et al, 2007; Endo et al, 2007
AKR1C1 *Dihydrodiol dehydrogenase Oxidoreductase, oxidation of trans-hydodiols NM_00135 Ciaccio et al, 1996
AMACR AMACR alpha-methylacyl-CoA racemase NM_014324 Chen et al, 2007
ARFRP1 ARF-related protein-1 GTPase NM_003224 Mueller et al, 2007
ART1 ART2.1 Ecto-ADP-ribosyltransferase NM_004314 Hong et al, 2007
ASS1 Argininosuccinate synthetase Arginine synthesis NM_000050 Fan et al, 2005; Brasse-Lagnel et al, 2007
ATP1A2 H+-K+ATPase alpha2 Role in potassium homeostasis NM_000702 Zhang & Kone, 2002;Saha et al 2008
BACE1 BACE-1 beta site APP cleaving enzyme NM_012104 Sambamurti et al, 2004; Rossner et al, 2006: Bourne et al, 2007; Bruggia-Prevot et al, 2008
BTK Btk Bruton's Tyrosine kinase NM_000061 Yu et al, 2008
CDK6 cdk6 Cell-dependent kinase 6   Iwanaga et al, 2008
CHI3L1 Chitinase 3-like protein Chitinase NM_001276 Recklies et al, 2005
CTSB Cathepsin B Lysosomal cysteine protease NM_001908 Bien et al, 2004
CTSL1 *Cathepsin L Lysosomal cysteine protease NM_001912 Seth et al, 2003
CYP19A1 Aromatase (promoter II) Estrogen synthesis NM_000103 Brasse-Lagnel et al, 2004
DIO2 Iodothyronine deiodinase (type 2) Converts T4 to T3 NM_000793 Fekete et al, 2003; Zeold et al, 2006
DNASE1L2 DNASIL2 DNAse-like endonuclease NM_001374 Shiokawa et al, 2004
DPYD *DYPD Dihydropyrimidine dehydrogenase NM_000110 Ukon et al, 2005
DUSP1 *MKP-1 MAP kinase phosphatase NM_004417 Zhou et al, 2003
ENO2 *ENO2 Enolase 2 gamma NM_001975 Carter et al, 2002
G6PC Glucose-6-phosphatase Hexose phosphatase NM_000151 Xu et al, 2007
G6PD *Glucose l-6-phosphate dehydrogenase Hexose monophosphate NM_000402 Garcia-Nogales et al, 1999
GAD1 *GAD67 Glutamic acid decarboxylase NM_000817 Szabo et al, 1996
GCLC Glutamate-cysteine ligase Glutathione S-transferase synthesis enzyme NM_001498 Yang et al, 2001; Nagashima et al, 2007
GCLC GCLC Glutamate-cysteine ligase catalytic subunit NM_001498 Yang et al, 2005
GCLC *gamma glutamylcysteine synthetase Glutatamylcysteine synthesis NM_001498 Cheng et al, 2005
GCLM *Glutamate-cysteine ligase modifier Glutathione S-transferase synthesis enzyme NM_002061 Yang et al, 2001
GCNT1 *N-acetylglucosaminyltransferase I (rat Gene) N-acetylglucosaminyltransferase NM_001097634 Fukuda et al, 2003
GNB2L1 RACK1 Receptor for Activated C kinase NM_006098 Choi et al, 2003
GNRH2 GnRH II Gonadotropin-releasing hormone II NM_001501 Hoo et al, 2007
GSTP1 GSTP1-1 Glutathione S-transferase NM_000852 Xia et al, 1996
GUCY1A2 *Soluble Guanylyl cyclase alpha (1) Receptor for NO NM_000855 Vazquez-Padron et al, 2004
GZMB Granzyme B NK cell cytotoxicity NM_004131 Huang et al, 2006
HAS1 Hyaluronan synthase Synthesizes hyaluronic acid NM_001523 Ohkawa et al, 1999; Kim, 2006; Saavalainen et al, 2007
HMOX1 HO-1 Hemeoxygenase NM_002133 Lavrovsky et al, 1994; Rushworth & O'Connell, 2004; Wu et al, 2004; Lin et al, 2007
HPSE *Heparanase Cleaves heparin NM_006665 Cao et al, 2005
HSD11B2 11bHSD2 11beta-hydroxysteroid dehydrogenase type 2 NM_000196 Kostadinova et al, 2005
HSD17B8 *17bHSD 17beta-hydroxysteroid dehydrogenase NM_014234 Villar et al, 2007
IDO1 *Indoleamine 2,3-dioxygenase Enzyme for Trp synthesis NM_002164 Ogasawara et al, 2009
LIPG EL Endothelial lipase NM_006033 Kempe et al, 2005
LYZ Lysozyme Hydrolyzes bacterial cell walls NM_000239 Phi van, 1996
MMP1 Collagenase 1 Matrix metalloproteinase NM_002421 Vincenti et al, 1998
MMP3 MMP-3, matrix metalloproteinaase-3 Secreted collagenase involved in metastasis NM_002422 Borghaei et al, 2004
MMP9 Gelatinase B Matrix metalloproteinase NM_004994 He, 1996
MMP9 MMP-9, matrix metalloproteinaase-9 Secreted collagenase involved in metastasis NM_004994 Bond et al, 1998; Farina et al, 1999; Yan et al, 2004
MTHFR Mthfr Methylenetetrahydrofolate reductase NM_005957 Pickell et al, 2005
MYLK MLCK (Long) Myosin light chain kinase NM_053025 Graham et al, 2006
NOS1 n-NOS Neuronal nitric oxide synthase NM_000620 Nakata et al, 2006; Li et al, 2007a, 2007b
NOS2A iNOS Inducible nitric oxide synthase NM_000625 Morris et al, 2003; Guo et al, 2006; Hughes et al, 2008
NOX1 gp91 phox Subunit of NADPH oxidase NM_007052 Anrather et al, 2006
NUAK2 SNARK SNF1/AMPK-related kinase NM_030952 Legembre et al, 2004
PAFAH2 Type II-secreted phospholipase A2 Proinflammatory phospholipase NM_000437 Couturier et al, 1999
PDE7A *PDE7A1 Phosphodiesterase 7A1 NM_002603 Torras-Llort, & Azorin, 2003
PIK3CA PIK3CA Phosphatidylinositol 3-kinase catalytic subunit NM_006218 Yang et al, 2008
PIM1 PIM-1 Ser/Thr kinase NM_002648 Zhu et al, 2002
PLCD1 PLCdelta 1 Phospholipase C isoform NM_006225 Kim et al, 2003
PLK3 Plk3 Polo-like (Ser/Thr) kinase 3 NM_004073 Li et al, 2005
PPP5C *PP5 Protein phosphatase 5 NM_006247 Matsuda et al, 2003
PRKACA PKAalpha Protein kinase A isoform NM_002730 Kaltschmidt et al, 2006
PRKCD PKCdelta Protein kinase D isoform NM_006254 Suh et al, 2003
PTGDS Lipocalin-type prostaglandin D synthase (L-PGDS) Prostaglandin D2 synthase in brain NM_000954 Fujimori et al, 2003
PTGES *PGES, prostaglandin E synthase Prostaglandin synthase NM_004878 Zhou et al, 2003
PTGIS *PTGIS, prostaglandin synthase Prostaglandin synthase NM_000961 Yokoyama et al, 1996
PTHLH PTHrP Parathryroid hormone related protein NM_002820 Nadella et al, 2007
PTPN1 PTP1B Protein tyrosine phosphatase 1B NM_002827 Zabolotny et al, 2008
Rdh1 *cis-retinoid/androgen dehydrogenase type 1 (CRAD1) Short chain dehydrogenase NM_080436 Chai et al, 2001
Rdh7 *cis-retinoid/androgen dehydrogenase type 2 (CRAD2) Short chain dehydrogenase NM_017473 Tomita et al, 2000
REV3L *REV3 DNA polymerase zeta NM_002912 Yu et al, 2004
SAT1 SSAT Spermidine/spermine N1-acetyltransferase NM_002970 Babbar et al, 2006
SERPINA2 Serpin 2A Serine protease XM_372532 Hampson et al, 2001
SERPINA3 alpha 1ACT Anti-chymotrypsin NM_001085 Kiss et al, 2005
Slfn2 Slfn-2 Schlafen-2 DNA/RNA helicase NM_011408 Sohn et al, 2007
ST6GAL1 SIAT1 Sialyltransferase NM_173216 Lo & Lau, 1999
ST8SIA1 GD3-synthase Sialyltransferase NM_003034 Zeng et al, 1998: Kang et al, 2007
SUPV3L1 *SUV3 ATP-dependent RNA and DNA helicase NM_003171 Minczuk et al, 2005
TERT TERT Telomerase catalytic subunit NM_198253 Yin et al, 2000: Hrdlickova et al, 2006
TGM1 Transglutaminase Forms isopeptide bonds NM_000359 Mirza et al, 1997
TGM2 TTG Tissue transglutaminase NM_004613 Chen et al, 2008
UGCGL1 *Ceramide glycosyltransferase Glycosphingolipid NM_020120 Ichikawa et al, 1998
UPP1 Uridine phosphorylase 5-fluorouracil and capecitabine metabolism NM_003364 Wan et al, 2006
XDH *Xanthine Dehydrogenase Oxidative metabolism of purines NM_000379 Xu et al, 1996
Growth factors, ligands, and their modulators
Human Gene Name Gene Function Acc # References
ANGPT1 Angiopoietin Tie-2 receptor ligand NM_001146 Scott et al, 2005
BDNF BDNF Brain-derived neurotrophic factor NM_001709 Saha et al, 2007
BLNK BLNK B-cell linker NM_013314 Gupta et al, 2008
BMP2 BMP-2 Bone Morphogenic Protein-2 NM_001200 Feng et al, 2003; Fukui et al, 2006
BMP4 BMP-4 Bone Morphogenic Protein-4 NM_001202 Zhu et al, 2007
CALCB CGRP Calcitonin Gene-related peptide NM_000728 Bowen et al, 2005
CSF1 M-CSF (CSF-1) Macrophage Colony Stimulating Factor NM_000757 Brach et al, 1991; Hohensinner et al, 2007
CSF2 GM-CSF Granulocyte Macrophage Colony Stimulating Factor NM_000758 Schreck & Baeuerle, 1990; Bunting et al, 2007
CSF3 G-CSF Granulocyte Colony Stimulating Factor NM_000759 Nishizawa & Nagata, 1990
EPO EPO Erythropoietin NM_000799 Figueroa et al, 2002
FGF8 FGF8 Fibroblast Growth Factor 8 NM_006119 Armstrong et al, 2006
FSTL3 FLRG Follistatin-related Gene NM_005860 Bartholin et al, 2007
HGF *HGF/SF Hepatocyte growth factor/scatter factor NM_000601 Harrison & Farzaneh, 2000
IGFBP1 *IGFBP-1 Insulin-like growth factor binding protein-1 NM_001013029 Lang et al, 1999
IGFBP2 IGFBP-2 Insulin-like growth factor binding protein-2 NM_000597 Cazals et al, 1999
INHBA Activin A TGF-beta-like factor NM_002192 Alexander et al, 2007
KITLG Stem Cell Factor Mast Cell Growth Factor NM_000899 Da Silva et al, 2003; 2004
MDK Midkine (neurite growth promoting factor-2) Heparin Binding Growth Factor NM_001012334 You et al, 2008
NGFB NGF Nerve Growth Factor NM_002506 Heese et al, 2006
NK4 NK4 Hepatocyte growth factor NM_001012635 Zhou et al, 2003
NRG1 Nrg1 Neuregulin NM_004495 Frensing et al, 2007
PDGFB PDGF B chain Platelet-derived Growth Factor NM_002608 Khachigian et al, 1995; Au et al, 2005
PENK Proenkephalin Hormone NM_006211 Rattner et al, 1991
PI3KAP1 BCAP B-cell Adaptor for Phosphoinositide 3-kinase NM_152309 Gupta et al, 2008
PIGF PlGF Placenta Growth Factor NM_002643 Cramer et al, 2005
PRL Prolactin Pituitary hormone NM_000948 Friedrichsen et al, 2005
SPP1 OPN Osteopontin NM_001040058 Samant et al, 2007
TACR1 NK-1R Neurokinin-1 Receptor NM_015727 Simeonidis et al, 2003; Ramkissoon et al, 2007
THBS1 *Thrombospondin-1 (TSP-1) Matrix glycoprotein t NM_003246 Yang et al, 2003
THBS2 *Thrombospondin-2 (THBS2) Matrix glycoprotein t NM_003247 Adolph et al, 1997
TNFSF13B BLyS B-lymphocyte stimulator NM_006573 Fu et al, 2006
VEGFC VEGF C Vascular Endothelial Growth Factor NM_005429 Chilov et al, 1997
WNT10B *WNT10B Secreted glycoprotein NM_003394 Katoh & Katoh, 2007
Immunoreceptors
Human Gene Name Gene Function Access # References
  Invariant Chain II Antigen presentation   Pessara & Koch, 1990
  MHC class I (H-2Kb) Major histocompatibility antigen   Israël et al, 1989a; Israël et al, 1989b
B2M b2 Microglobulin Chaperone for MHC class I-like molecules NM_004048 Israël et al, 1989a; Israël et al, 1989b; Gobin et al, 2002
BDKRB1 Kinin B1 Receptor Cardiovascular homeostasis; inflammation NM_000710 Merino et al, 2005
BLR1 BRL-1 B-cell homing receptor NM_001716 Wolf et al, 1998
CCR5 CCR5 Chemokine receptor NM_000579 Liu et al, 1998
CCR7 CCR7 Chemokine receptor NM_001838 Hopken et al, 2002
CD38 CD38 NAD to cADP ribose converting molecule NM_001775 Kang et al, 2006; Tirumurugaan et al, 2008
CD3G CD3gamma T-cell marker NM_000073 Willard-Gallo et al, 2005
CD3G T-cell receptor/CD3gamma T-cell receptor subunit NM_000073 Badran et al, 2002
CD40 CD40 TNF-receptor family member NM_001250 Hinz et al, 2001
CD40LG CD154 CD40 ligand NM_000074 Srahna et al, 2001; Schubert et al, 2002; Pham et al, 2005
CD48 CD48 Antigen of stimulated lymphocytes NM_001778 Klaman & Thorley-Lawson, 1995
CD80 B7.1 (CD80) Co-stimulation of T cells via CD28 binding NM_005191 Fong et al, 1996; Zhao et al, 1996
CD83 CD83 T-cell development molecule NM_004233 McKinsey et al, 2000; Berchtold et al, 2002
CD86 CD86 Dendritic cell development molecule NM_175862 Zou & Hu, 2005
CR2 CD21 B-cell surface molecule NM_001006658 Debnath et al, 2007
F11R *F11-receptor Ig-like receptor for platelet adhesion NM_016946 Sobocki et al, 2005
FCER2 Fc epsilon receptor II (CD23) Receptor for IgE NM_002002 Richards & Katz, 1997; Lu et al, 2006; Debnath et al, 2007
FCGRT FcRn Neonatal receptor for IgG NM_004107 Liu et al, 2007
HLA-B MHC Class I HLA-B7 Major histocompatibility antigen NM_005514 Johnson & Pober, 1994
HLA-G HLA-G Human leukocyte antigen-G NM_002127 Langat et al., 2007
ICOS *ICOS T-cell activation factor NM_012092 Shilling et al., 2005
IGHE Immunoglobulin e heavy chain IgE heavy chain J00222 Iciek et al, 1997
IGHG1 Immunoglobulin gamma1 IgG heavy chain J00228 Dryer & Covey, 2005
IGHG2 Immunoglobulin Cgamma1 IgG heavy chain J00230 Lin & Stavnezer, 1996
IGHG4 Immunoglobulin gamma4 IgG heavy chain K01316 Agresti & Vercelli, 2002
IGKC Immunoglobulin k light chain Antibody light chain J00241 Sen & Baltimore, 1986
IL2RA IL-2 receptor a-chain IL-2 receptor subunit NM_000417 Ballard et al., 1988
IL8RA CXCR Chemokine receptor NM_000634 Maxwell et al, 2007
IL8RB CXCR2 Chemokine receptor NM_001557 Maxwell et al, 2007
NOD2 Nod2 Intracellular pathogen recognition NM_022162 Gutierrez et al, 2002
PGLYRP1 PGRP-S Peptidoglycan recognition protein-S NM_005091 Lang et al, 2007
pIgR Polymeric Ig receptor Binds Ig AJ276452 Schjerven et al, 2001
SLC3A2 CD98 Membrane receptor, survival blood cells NM_001012661 Yan et al, 2006
TCRB T-cell receptor b chain T-cell receptor subunit NG_001333 Jamieson et al, 1989; McMillan & SIkes, 2008
TLR2 TLR-2 Toll-like receptor NM_003264 Wang et al, 2001; Johnson & Tapping, 2007
TLR9 TLR9 Toll-like receptor NM_017442 Takeshita et al, 2004
TNFRSF1B *TNF-Receptor, p75/80 (CD120B) High-affinity TNF receptor NM_001066 Santee & Owen-Schaub, 1996
TNFRSF4 CD134 TNF-like receptor NM_003327 Tone et al, 2007
TNFRSF9 CD137 TNF-like receptor NM_001561 Kim et al, 2003
TREM1 TREM-1 Neutrophil/monocyte Ig receptor NM_018643 Zeng et al, 2007
Others
Human Gene Name Gene Function Acc # References
  *Clone 330 Possible secreted protein   Matsuda et al, 2003
  *Clone 156 Unknown NF-kB inducer   Matsuda et al, 2003
  *Clone 68 Unknown NF-kB inducer   Matsuda et al, 2003
  Mir125b Micro-RNA TNFa   Tili et al, 2007
  Mir146a, b Micro-RNA for IRAK and Traf6   Taganov et al, 2006
  Mir155 Micro-RNA for FADD, IKKe, Ripk1   Tili et al, 2007
A4 *beta-amyloid Alzheimer's precursor NM_000484 Song & Lahiri, 1998
ABCG5 *ABCG5 (bovine) ATP-binding cassette sterol transporters NM_022436 Viturro et al, 2006
ABCG8 ABCG8 (bovine) ATP-binding cassette sterol transporters NM_022437 Viturro et al, 2006
AFP alpha-fetoprotein Liver cancer marker NM_001134 Cavin et al, 2004
AMH AMH Anti-Mullerian hormone NM_000479 Lukas-Croisier et al, 2003
APOBEC2 APOBEC2 Apolipoportein B mRNA-editing enzyme catalytic subunit 2 NM_006789 Matsumoto et al, 2006
APOC3 Apolipoprotein C III Apoprotein of HDL NM_000040 Gruber et al, 1994
APOD Apolipoprotein D Plasma lipocalin NM_001647 Do Carmo et al, 2007
APOE Apolipoprotein E Protein assoc. with Alzheimers NM_000041 Lahiri, 2004; Du et al, 2005
AQP4 AQP4 Aquaporin 4 NM_001650 Ito et al, 2006
ASPH AbetaH-J-J Tripartite Gene: aspartyl-beta-hydroxylase, junctin), junctate NM_004318 Feriotto et al, 2005
BGN *Biglycan Connective tissue proteoglycan NM_001711 Ungefroren & Krull, 1996
BRCA2 BRCA2 Breast Cancer Susceptibility protein-2 NM_000059 Wu et al, 2000
CAV1 *Caveolin-1 Lipid raft protein NM_001753 Deregowski et al, 2002
CCND1 Cyclin D1 Cell-cycle regulation NM_053056 Guttridge et al, 1999; Hinz et al, 1999; Toualbi-Abed et al, 2008
CCND2 Cyclin D2 Cell-cycle regulation NM_001759 Huang et al, 2004; Iwanaga et al, 2008
CCND3 *Cyclin D3 Cell-cycle regulation NM_001760 Wang et al, 1996
CDKN1A *p21-CIP1 Cyclin-dependent kinase inhibitor NM_000389 Hinata et al, 2003
CGM3 Pregnancy-specific glycoprotein rnCGM3 Placental expression NM_019126 Wang et al, 2001
CLDN2 *Claudin-2 Gap junction protein NM_020384 Yamamoto et al, 2004
COL1A2 a2(I) collagen Type I collagen NM_000089 Novitskiy et al, 2004; Nieto, 2007
CXCL1 Gro-1 Growth regulated oncoGene; chemokine NM_001511 Wood, 1995
CYP27B1 25-hydroxyvtamin D3 1alpha hydroxylase Enzyme for liver vitamin D3 production NM_000785 Ebert et al, 2004
EDN1 Endothelin 1 Vasoconstrictor peptide/mitogen NM_001955 Quehenberger et al, 2000
EPHA1 Ephrin-A1 Cell-cycle regulation NM_005232 Deregowski et al, 2002
ERVWE1 Syncytin-1 Env glycoprotein of endogenous human retrovirus NM_014590 Mameli et al, 2007
F8 Factor VIII Hemostasis NM_000132 Figueiredo & Brownlee, 1995
FABP6 IBABP Ileal bile acid binding protein NM_001445 Fang et al, 2007
FAM148A NLF1 IL-1beta induced NM_207322 Warton et al, 2004
FTH1 Ferritin Heavy Chain Anti-oxidant NM_002032 Kwak et al, 1995
GADD45B Gadd45beta DNA repair/cell cycle NM_015675 De Smaele et al, 2001; Qiu et al, 2004
GBP1 GBP-1 GTPase guanylate binding protein NM_002053 Naschberger et al, 2004
GJB1 *Connexin32 Gap junction protein NM_000166 Yamamoto et al, 2004
GNAI2 Galpha i2 G protein NM_002070 Arinze & Kawai, 2005
HBE1 epsilon-Globin Globin protein NM_005330 Hou et al, 2002, 2004
HBZ zeta-Globin Globin protein NM_005332 Wang & Liebhaber, 1999
HMGN1 HMG14 High mobility group 14 NM_004965 Walker & Enrietto, 1996
IER3 DIF2 Monocyte differentiation Gene NM_003897 Witcher et al, 2007
IFI44L *GS3686 Homology to microtubule aggregating protein NM_006820 Carter et al, 2002
IGFBP2 IMP2 Insulin-like growth factor-II mRNA binding protein NM_000597 Cleynen et al, 2007
KCNK5 TASK-2 Tandem P domain potassium channel NM_003740 Brazier et al, 2005
KCNN2 SK2 channels Small-conductance Ca2+-activated channels NM_021614 Kye et al, 2007
KLK3 Prostate-specific antigen Serum protein in prostate cancer NM_001030047 Chen & Sawyers, 2002
KRT15 K15 Keratin Intermediate filament protein NM_002275 Radoja et al, 2004
KRT3 K3 Keratin Intermediate filament protein NM_057088 Wu et al, 1994
KRT5 Hair K5 keratin Hair keratin protein NM_000424 Gilon et al, 2007
KRT6B K6b Keratin Intermediate filament protein NM_005555 Komine et al, 2000
LAMB2 Laminin B2 Chain Basement membrane protein NM_002292 Richardson et al, 1995
LCN2 Lipocalin-2 Iron-siderophore-binding protein NM_005564 Fujino et al, 2005
LCN2 Neutrophil gelatinase-associated lipocalin Anti-microbial protein in lung NM_005564 Cowland et al, 2003
LGALS3 Galectin 3 b-galactosidase-binding lectin NR_003225 Hsu et al, 1996
LTF *Lactoferrin Milk protein NM_002343 Zheng et al, 2005
MBP Myelin basic protein Neural sheath NM_001025081 Paez et al, 2006
MT3 *GIF Cys-rich metal binding protein NM_005954 Hinata et al, 2003
MUC2 Mucin (MUC-2) Airway defense glycoprotein NM_002457 Jono et al, 2002; Lee et al, 2000
MYOZ1 Calsarcin-1 Muscle cell calcineurin-interacting protein NM_021245 Wang et al, 2007
OPN1SW SWS1 Rainbow trout opsin NM_001708 Dann et al, 2004
ORM1 alpha-1 acid glycoprotein Serum protein NM_000607 Mejdoubi et al, 1999
PAX8 *Pax8 Paired box Gene NM_003466 Okladnova et al, 1997
PDYN Prodynorphin Neuropeptide NM_024411 Bakalkin et al, 1994
PGK1 *PGK1 Phosphoglycerate kinase 1 NM_000291 Carter et al, 2002
POMC POMC Proopiomelanocortin NM_000939 Karalis et al, 2004; Asaba et al, 2007
PPARGC1B PGC-1β mitochondrial regulator PPAR-γ coactivator 1β NM_001172698.1 Bakkar et. al. 2012
PRF1 Perforin Pore-forming effector molecule NM_005041 Zhou et al, 2002
PSME1 PA28 alpha Proteasome activator NM_006263 Ossendorp et al, 2005
PSME2 PA28 beta Proteasome activator NM_002818 Ossendorp et al, 2005
PTEN PTEN Tumor suppressor NM_000314 Xia et al, 2007
PTS *PCBD 6-pyruvoyl-tetrahydropterin synthase NM_000317 Carter et al, 2002
RAG1 RAG-1 Immunoglobulin recombinase Genes NM_000448 Verkoczy et al, 2005
RAG2 RAG-2 Immunoglobulin recombinase Genes NM_000536 Verkoczy et al, 2005
RBBP4 RbAp48 Retinoblastoma-associated protein 48 NM_005610 Pacifico et al, 2007
RIPK2 *RICK Adaptor NM_003821 Matsuda et al, 2003
S100A10 *p11 Annexin II ligand NM_002966 Huang et al, 2003
S100A4 Mts1 Multiple tumor suppressor NM_002961 Tulchinsky et al, 1997
S100A6 S100A6 (calcyclin) Calcium binding protein NM_014624 Joo et al, 2003
SDC4 Syndecan-4 Heparin sulfate proteoglycan NM_002999 Zhang et al, 1999
SERPINA1 a1-antitrypsin Protease inhibitor NM_000295 Ray et al, 1995
SERPINB1 MNE1 Monocyte/neutrophil elastase inhibitor NM_030666 Zeng et al, 2000
SERPINE1, PAI-1 PAI-1 Plasminogen activator inhibitor NM_000602 Hou et al, 2004
SERPINE2 SerpinE2 Serine protease inhibitor NM_006216 Suzuki et al, 2006
SH3BGRL SH3BGRL SH3-binding glutamic acid-rich protein NM_003022 Majid et al, 2005
SKALP, PI3 Elafin Proteinase inhibitor NM_002638 Bingle et al, 2001
SKP2 Skp2 S-phase kinase-associated protein 2 NM_005983 Schneider et al, 2006
SLC11A2 DMT1 Divalent metal ion transporter NM_000617 Paradkar et al, 2005
SLC16A1 MCT1 Monocarboxylate transporter isoform 1 NM_003051 Borthakur et al, 2007
SLC6A6 TAUT Taurine Uptake Transporter NM_003043 Mochizuki et al, 2005
SPATA19 *Spergen-1 Sperm-specific mitochondrial protein NM_174927 Matsuoka et al, 2004
TF *Transferrin (mosquito) Probable iron transport protein NM_001063 Harizanova et al, 2005
TFPI2 *Tissue factor pathway inhibitor-2 (TFPI-2) Serine protease inhibitor NM_006528 Konduri et al, 2003a, 2003b; Hube et al, 2003
TICAM1 TRIF TIR-containing adaptor protein inducing interferon beta NM_014261 Hardy et al, 2004
TNIP1 Naf1 Associates with HIV Nef NM_006058 Tian et al, 2005
TRPC1 TRPC1 Thrombin activation of protease-activated receptor-1 NM_003304 Paria et al, 2006
UBE2M *UBE2M Ubiquitin conjugating enzyme E2M NM_003969 Carter et al, 2002
UCP2 *UCP-2 Uncoupling protein-2 NM_003355 Lee et al, 1999
UPK1B Uroplakin Ib Surface structural protein on urothelial cells NM_006952 Varga et al, 2004
VIM Vimentin Intermediate filament protein NM_003380 Lilienbaum et al, 1990; Zheng et al, 2005
VPS53 *HCCS1 Hepatocarcinoma suppressor 1 NM_018289 Zhu et al, 2006
Proteins involved in antigen presentation
Human Gene Name Gene Function Acc # References
C3 Complement component 3 Component of complement pathway NM_000064 Moon et al, 1999
CFB Complement B Activator of alternative complement pathway NM_001710 Huang et al, 2002
CR2 Complement Receptor 2 Complement receptor for B-cell response to Ag NM_001006658 Tolnay et al, 2002
PSMB9 Proteasome Subunit LMP2 Subunit of 26S proteasome,cysteine protease NM_002800 Wright et al, 1995; Marques et al, 2004
TAP1 Peptide Transporter TAP1 Peptide transporter for ER NM_000593 Wright et al, 1995; Marques et al, 2004
TAPBP Tapasin MHC class I presentation and assembly NM_003190 Herrmann et al, 2003
Stress response Genes
Human Gene Name Gene Function Acc # References
ALOX12 12-Lipoxygenase Arachidonic acid metabolic enzyme NM_000697 Arakawa et al, 1995
ALOX5 *5-Lipoxygenase (guinea pig) Arachidonic acid metabolic enzyme, leukotriene synthesis XM_001127464 Chopra et al, 1992
CYP2C11 CYP2C11 Cytochrome p450 X79081 Morgan et al, 2002
CYP2E1 *CYP2E1 Cytochrome p450 NM_000773 Abdel-Razak et al, 2004
CYP7B1 CYP7b Cytochrome p450 NM_004820 Dulos et al, 2005
FTH1 Ferritin H chain Iron storage protein NM_002032 Kwak et al, 1995
GCLC Glutamate-cysteine ligase GSH biosynthesis   Peng et al, 2010
GCLM Glutamate-cysteine ligase modifier GCLC modifier protein   Peng et al, 2010
HSP90AA1 HSP90-alpha Heat shock protein NM_001017963 Ammirante et al, 2007
MAP4K1 *MAP4K1 Activator of stress-induced protein kinase pathway NM_001042600 Carter et al, 2002
MX1 *Mx1 Viral resistance Gene NM_002462 Gerardin et al, 2004
NOS2A Inducible NO-Synthase NO synthesis NM_000625 Geller et al, 1993
NQO1 NAD(P)H quinone oxidoreductase (DT-diaphorase) Bioreductive enzyme NM_000903 Yao & O'Dwyer, 1995
PLA2 Phospholipase A2 Fatty acid metabolism AF058921 Morri et al, 1994
PTGS2 COX-2 Cyclooxygenase, prostaglandin endoperoxide synthase NM_000963 Yamamoto et al, 1995;Ackerman et al, 2008; Kaltschmidt et al, 2002
SELS SEPS1 Involved in cytokine production NM_018445 Gao et al, 2006
SENP2 SENP2 SUMO-specific protease NC_0000013.10 S Miyamoto, pers commun
SOD1 Cu/Zn SOD Superoxide dismutase NM_000454 Rojo et al, 2004
SOD1 SOD1 Manganese uperoxide dismutase NM_000454 Das et al, 1995
SOD2 SOD2 Manganese superoxide dismutase NM_000636 Xu et al, 1999a; 1991b; 2007a; 2007b
Transcription factors and their modulators
Human Gene Name Gene Function Acc # References
AHCTF1 *ELYS Embryonic large molecule derived from yolk sac NM_015446 Okita et al, 2003
AR Androgen receptor Hormone receptor NM_000044 Zhang et al, 2004
BCL3 Bcl-3 Coactivator for NF-kB p50 and p52 NM_005178 Brocke-Heidrich et al, 2006
BMI1 BMI-1 Polycomb chromatin modifier NM_005180 Dutton et al, 2006
CDX1 CDX1 Homeobox protein NM_001804 Wong et al, 2005
CEBPD C/EBPdelta Transcription factor NM_005195 Liu et al, 2007
CREB3 LZIP Leukocyte cell mobility NM_006368 Jang et al, 2007
DMP1 Dmp1 Myb-like transcription factor NM_001079911 Taneja et al, 2007
E2F3 E2F3a Cell cycle regulator NM_001949 Cheng et al, 2003
ELF3 Elf3 Ets family transcription factor NM_004433 Hou et al, 2004
FOS *c-fos (fish Gene) Proto-oncoGene NM_005252 Li et al, 2004
GATA3 Gata-3 T-cell differentiation Factor NM_001002295 Corn et al, 2005
HIF1A HIF-1alpha Hypoxia-inducible factor NM_001530 Bonello et al, 2007; Belaiba et al, 2007; van Uden et al, 2008; Gorlach & Bonello, 2008
HOXA9 HOXA9 Homeobox protein NM_152739 Trivedi et al, 2007
IER2 *ETR101 TPA-inducible, Jun-like transcription factor NM_004907 Zhou et al, 2003
IRF1 IRF-1 Interferon regulatory factor-1 NM_002198 Harada et al, 1994; Robinson et al, 2006
IRF2 IRF-2 Interferon regulatory factor-2 NM_002199 Harada et al, 1994
IRF4 IRF-4 Interferon regulatory factor-4 NM_002460 Grumont & Gerondakis, 2000; Saito et al, 2007
IRF7 IRF-7 Interferon regulatory     factor -7 NM_001572 Lu et al, 2002
JMJD3 jmjD3 Histone lysine demethylase XM_043272 G Natoli, pers comm
JUNB junB Proto-oncogene NM_002229 Brown et al, 1995
LEF1 Lef1 Transcription factor in Wnt/b-catenin pathway NM_016269 Yun et al, 2007
MYB c-myb Proto-oncoGene NM_005375 Toth et al, 1995
MYC c-myc Proto-oncoGene NM_002467 Duyao et al, 1990
NFKB1 nfkb1 NF-kB p105 precursor NM_003998 Ten et al, 1992
NFKB2 nfkb2 NF-kB p100 precursor NM_001077493 Lombardi et al, 1995
NFKBIA IkB-a Inhibitor of Rel/NF-kB NM_020529 Haskill et al, 1991; Sun et al, 1993 de Martin et al, 1993
NFKBIE IkB-e Inhibitor of Rel/NF-kB NM_004556 Tian et al, 2005
NFKBIZ Mail IkB-like protein NM_001005474 Shiina et al, 2001; Ito et al, 2004
NLRP2 NLRP2 NF-kB pathway inhibitor NM_017852 Fontalba et al, 2007
NR3C1 *Glucocorticoid receptor Promoter 1B of the GR NM_000176 Schaff & Cidlowski, 2002
NR4A2 NURR1 Nuclear orphan receptor NM_006186 McEvoy et al, 2002
Osterix Osterix Bone transcription factor AF477981 Lu et al, 2006
PGR Progesterone receptor Transcription factor NM_000926 Condon et al, 2005
REL c-rel Proto-oncoGene NM_002908 Hannink & Temin, 1990; Capobianco & Gilmore, 1991
RELB relb Transcription factor NM_006509 Bren et al, 2001
SNAI1 Snail Transcription factor NM_005985 Barbera et al, 2004; Julien et al, 2007
SOX9 Sox9 Transcription factor NM_000346 Murakami et al, 2000
SPI1 PU.1 Transcription factor NM_001080547.1 Bonadies et al, 2009
STAT5A Stat5a Transcription factor NM_003152 Hinz et al, 2002
TFEC Tfec Transcription factor NM_001018058 Rehli et al, 2005
TNFAIP3 A20 TNF-inducible zinc finger NM_006290 Krikos et al, 1992
TNIP3 ABIN-3 NF-kB inhibitor NM_024873 Verstrepen et al, 2007
TP53 p53 TF, Tumor suppressor NM_000546 Wu & Lozano, 1994; Schumm et al, 2006
TWIST1 Twist Transcription repressor NM_000474 Horikawa et al, 2007; Pham et al, 2007
WT1 WT1 Zinc finger transcription factor NM_000378 Dehbi et al, 1998; Chen & Williams, 2000
YY1 YY1 Transcription factor NM_003403 Wang et al, 2007
ZNF366 *DC-SCRIPT Dendritic cell zinc finger protein NM_152625 Triantis et al, 2006