| Gene Symbol (Name) | Description | Change gender | Age change starts | Age change ends | Tissues | Percentage change | P value | References |
| 0910001L09Rik (RIKEN cDNA 0910001L09 gene) | Male and Female | 8 | 24 | Muscle | -6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 1110002B05Rik (RIKEN cDNA 1110002B05 gene) | Male and Female | 6 | 22 | Liver | 5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| 1110008P14Rik (RIKEN cDNA 1110008P14 gene) | Male and Female | 5 | 30 | Anatomical System | -2.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| 1500001M20Rik (RIKEN cDNA 1500001M20 gene) | Male and Female | 3 | 23 | Hematological System | -8.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 1600015I10Rik (RIKEN cDNA 1600015I10 gene) | Male and Female | 5 | 22 | Brain | -53.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 1600029I14Rik (RIKEN cDNA 1600029I14 gene) | Male and Female | 3 | 23 | Hematological System | 16.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 1700006E09Rik (RIKEN cDNA 1700006E09 gene) | Male and Female | 3 | 23 | Hematological System | 88.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 1700056E22Rik (RIKEN cDNA 1700056E22 gene) | Male and Female | 2 | 26 | Lung | 91.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 1810044D09Rik (RIKEN cDNA 1810044D09 gene) | Male and Female | 3 | 23 | Hematological System | 4.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 2310033P09Rik (RIKEN cDNA 2310033P09 gene) | Male and Female | 3 | 23 | Hematological System | -1.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 2310037I24Rik (RIKEN cDNA 2310037I24 gene) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 2410017P09Rik (RIKEN cDNA 2410017P09 gene) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 2610005L07Rik (RIKEN cDNA 2610005L07 gene) | Male and Female | 5 | 22 | Brain | 2.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 2610018G03Rik (RIKEN cDNA 2610018G03 gene) | Male and Female | 8 | 24 | Muscle | 5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 2610201A13Rik (RIKEN cDNA 2610201A13 gene) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| 2700007P21Rik (RIKEN cDNA 2700007P21 gene) | Male and Female | 8 | 24 | Muscle | -6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 2810021B07Rik (RIKEN cDNA 2810021B07 gene) | Male and Female | 2 | 26 | Lung | 5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 2810038L03Rik (RIKEN cDNA 2810038L03 gene) | Male and Female | 5 | 22 | Brain | 382.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 2810405K02Rik (RIKEN cDNA 2810405K02 gene) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 3830431G21Rik (RIKEN cDNA 3830431G21 gene) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 4732418C07Rik (RIKEN cDNA 4732418C07 gene) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| 4833411C07Rik (RIKEN cDNA 4833411C07 gene) | Male and Female | 5 | 22 | Brain | 114.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 4930453L07Rik (RIKEN cDNA 4930453L07 gene) | Male and Female | 5 | 22 | Brain | -51.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 4930456G14Rik (RIKEN cDNA 4930456G14 gene) | Male and Female | 2 | 26 | Lung | 55.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 4930517J16Rik (RIKEN cDNA 4930517J16 gene) | Male and Female | 5 | 30 | Anatomical System | 146.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| 4930578I06Rik (RIKEN cDNA 4930578I06 gene) | Male and Female | 3 | 23 | Hematological System | 58.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 4933433G19Rik (RIKEN cDNA 4933433G19 gene) | Male and Female | 3 | 23 | Hematological System | -12.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| 5430427O19Rik (RIKEN cDNA 5430427O19 gene) | Male and Female | 5 | 22 | Brain | -84.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| 8430408G22Rik (RIKEN cDNA 8430408G22 gene) | Male and Female | 2 | 26 | Lung | 8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 8430436O14Rik (RIKEN cDNA 8430436O14 gene) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| 9030418K01Rik (RIKEN cDNA 9030418K01 gene) | Male and Female | 3 | 23 | Hematological System | 7.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| A130082M07Rik (RIKEN cDNA A130082M07 gene) | Male and Female | 2 | 26 | Lung | 19.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| A230006K03Rik (RIKEN cDNA A230006K03 gene) | Male and Female | 8 | 24 | Muscle | -16.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| A230038B01Rik (RIKEN cDNA A230038B01 gene) | Male and Female | 5 | 22 | Brain | 240.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| A930005H10Rik (RIKEN cDNA A930005H10 gene) | Male and Female | 3 | 23 | Hematological System | 7.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| AACS (acetoacetyl-CoA synthetase) | Using a linear mixed model, differential expression with age was identified in AACS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AADAC (arylacetamide deacetylase) | Using a linear mixed model, differential expression with age was identified in AADAC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Abat (4-aminobutyrate aminotransferase) | Male and Female | 3 | 23 | Hematological System | 45.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ABCA1 (ATP-binding cassette, sub-family A (ABC1), member 1) | Using a linear mixed model, differential expression with age was identified in ABCA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4) | Using a linear mixed model, differential expression with age was identified in ABCA4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) | Using a linear mixed model, differential expression with age was identified in ABCA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABCA8 (ATP-binding cassette, sub-family A (ABC1), member 8) | Comparison of DNA methylation showed a significantly decreased methylation level of ABCA8 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -23.4 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ABCA8 (ATP-binding cassette, sub-family A (ABC1), member 8) | Comparison of DNA methylation showed a significantly decreased methylation level of ABCA8 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -25.0 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) | Using a linear mixed model, differential expression with age was identified in ABCB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1) | Male and Female | 2 | 26 | Lung | 2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ABCC4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) | Using a linear mixed model, differential expression with age was identified in ABCC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABHD12 (abhydrolase domain containing 12) | Using a linear mixed model, differential expression with age was identified in ABHD12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABHD12B (abhydrolase domain containing 12B) | Using a linear mixed model, differential expression with age was identified in ABHD12B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Abhd14a (abhydrolase domain containing 14A) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ABHD14A (abhydrolase domain containing 14A) | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ABHD14A (abhydrolase domain containing 14A) | Using a linear mixed model, differential expression with age was identified in ABHD14A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABHD14A (abhydrolase domain containing 14A) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ABHD14A and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ABHD5 (abhydrolase domain containing 5) | Using a linear mixed model, differential expression with age was identified in ABHD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABI2 (abl-interactor 2) | Male and Female | 26 | 106 | Brain | -18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ABI3BP (ABI family, member 3 (NESH) binding protein) | Using a linear mixed model, differential expression with age was identified in ABI3BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ABLIM1 (actin binding LIM protein 1) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ABLIM2 (actin binding LIM protein family, member 2) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396) | |
| ACACA (acetyl-CoA carboxylase alpha) | Gene expression showed a significant (p<E-3) increase in the expression of ACACA in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 63.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ACACA (acetyl-CoA carboxylase alpha) | Using a linear mixed model, differential expression with age was identified in ACACA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACACA (acetyl-CoA carboxylase alpha) | Using a linear mixed model, differential expression with age was identified in ACACA in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACAD10 (acyl-CoA dehydrogenase family, member 10) | Using a linear mixed model, differential expression with age was identified in ACAD10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACAD11 (acyl-CoA dehydrogenase family, member 11) | Using a linear mixed model, differential expression with age was identified in ACAD11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACAD8 (acyl-CoA dehydrogenase family, member 8) | Using a linear mixed model, differential expression with age was identified in ACAD8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACADL (acyl-CoA dehydrogenase, long chain) | Using a linear mixed model, differential expression with age was identified in ACADL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACADM (acyl-CoA dehydrogenase, C-4 to C-12 straight chain) | Using a linear mixed model, differential expression with age was identified in ACADM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACADVL (acyl-CoA dehydrogenase, very long chain) | Using a linear mixed model, differential expression with age was identified in ACADVL in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACAT2 (acetyl-CoA acetyltransferase 2) | Using a linear mixed model, differential expression with age was identified in ACAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Accn1 (amiloride-sensitive cation channel 1, neuronal (degenerin)) | Male and Female | 2 | 26 | Lung | 57.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ACE2 (angiotensin I converting enzyme 2) | Using a linear mixed model, differential expression with age was identified in ACE2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACER3 (alkaline ceramidase 3) | Using a linear mixed model, differential expression with age was identified in ACER3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACIN1 (apoptotic chromatin condensation inducer 1) | Using a linear mixed model, differential expression with age was identified in ACIN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACLY (ATP citrate lyase) | Using a linear mixed model, differential expression with age was identified in ACLY in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACO1 (aconitase 1, soluble) | Using a linear mixed model, differential expression with age was identified in ACO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACOT11 (acyl-CoA thioesterase 11) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ACOT11 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Acot7 (acyl-CoA thioesterase 7) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ACOT7 (acyl-CoA thioesterase 7) | Using a linear mixed model, differential expression with age was identified in ACOT7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACSBG1 (acyl-CoA synthetase bubblegum family member 1) | Using a linear mixed model, differential expression with age was identified in ACSBG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACSL5 (acyl-CoA synthetase long-chain family member 5) | Using a linear mixed model, differential expression with age was identified in ACSL5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Acsm2 (acyl-CoA synthetase medium-chain family member 2) | Male and Female | 3 | 23 | Hematological System | -29.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ACSM3 (acyl-CoA synthetase medium-chain family member 3) | Using a linear mixed model, differential expression with age was identified in ACSM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Acss1 (acyl-CoA synthetase short-chain family member 1) | Male and Female | 2 | 15 | Hippocampus | -2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| ACSS2 (acyl-CoA synthetase short-chain family member 2) | Using a linear mixed model, differential expression with age was identified in ACSS2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACSS2 (acyl-CoA synthetase short-chain family member 2) | Using a linear mixed model, differential expression with age was identified in ACSS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACTA1 (actin, alpha 1, skeletal muscle) | Male and Female | 26 | 106 | Brain | -16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Acta1 (actin, alpha 1, skeletal muscle) | Male and Female | 5 | 25 | Skeletal Muscle | 55.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ACTB (actin, beta) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Actc1 (actin, alpha, cardiac muscle 1) | Male and Female | 8 | 24 | Muscle | -13.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ACTC1 (actin, alpha, cardiac muscle 1) | Male and Female | 20 | 75 | Skeletal Muscle | 8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ACTC1 (actin, alpha, cardiac muscle 1) | Using a linear mixed model, differential expression with age was identified in ACTC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACTG2 (actin, gamma 2, smooth muscle, enteric) | Using a linear mixed model, differential expression with age was identified in ACTG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACTL6A (actin-like 6A) | Male and Female | 26 | 106 | Brain | 21.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ACTN3 (actinin, alpha 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ACTN3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ACTR5 (ARP5 actin-related protein 5 homolog (yeast)) | Using a linear mixed model, differential expression with age was identified in ACTR5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Actr6 (ARP6 actin-related protein 6 homolog (yeast)) | Male and Female | 5 | 25 | Skeletal Muscle | 7.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ACVR1B (activin A receptor, type IB) | Gene expression showed a significant (p<E-3) increase in the expression of ACVR1B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 51.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ACVR1B (activin A receptor, type IB) | Using a linear mixed model, differential expression with age was identified in ACVR1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACVR2A (activin A receptor, type IIA) | Using a linear mixed model, differential expression with age was identified in ACVR2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ACYP1 (acylphosphatase 1, erythrocyte (common) type) | Using a linear mixed model, differential expression with age was identified in ACYP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADA (adenosine deaminase) | Using a linear mixed model, differential expression with age was identified in ADA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADA (adenosine deaminase) | Using a linear mixed model, differential expression with age was identified in ADA in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Adam25 (a disintegrin and metallopeptidase domain 25 (testase 2)) | Male and Female | 3 | 23 | Hematological System | 9.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ADAMTSL3 (ADAMTS-like 3) | Using a linear mixed model, differential expression with age was identified in ADAMTSL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADAP2 (ArfGAP with dual PH domains 2) | Using a linear mixed model, differential expression with age was identified in ADAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADARB1 (adenosine deaminase, RNA-specific, B1) | Using a linear mixed model, differential expression with age was identified in ADARB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADCK1 (aarF domain containing kinase 1) | Using a linear mixed model, differential expression with age was identified in ADCK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADCK2 (aarF domain containing kinase 2) | Using a linear mixed model, differential expression with age was identified in ADCK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADCK3 (aarF domain containing kinase 3) | Using a linear mixed model, differential expression with age was identified in ADCK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADCK5 (aarF domain containing kinase 5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of ADCK5 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| ADIPOR2 (adiponectin receptor 2) | Using a linear mixed model, differential expression with age was identified in ADIPOR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ADM (adrenomedullin) | Using a linear mixed model, differential expression with age was identified in ADM in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Adssl1 (adenylosuccinate synthetase like 1) | Male and Female | 5 | 25 | Skeletal Muscle | -13.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of AGAP1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) | Using a linear mixed model, differential expression with age was identified in AGAP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AGBL5 (ATP/GTP binding protein-like 5) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| AGBL5 (ATP/GTP binding protein-like 5) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| AGBL5 (ATP/GTP binding protein-like 5) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| AGBL5 (ATP/GTP binding protein-like 5) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) | Using a linear mixed model, differential expression with age was identified in AGPAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) | Using a linear mixed model, differential expression with age was identified in AGPAT3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AGTPBP1 (ATP/GTP binding protein 1) | Using a linear mixed model, differential expression with age was identified in AGTPBP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AGTRAP (angiotensin II receptor-associated protein) | Using a linear mixed model, differential expression with age was identified in AGTRAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AHCTF1 (AT hook containing transcription factor 1) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1) | Male and Female | 5 | 22 | Brain | 1.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| AHCYL2 (adenosylhomocysteinase-like 2) | Using a linear mixed model, differential expression with age was identified in AHCYL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AHNAK (AHNAK nucleoprotein) | Male and Female | 26 | 106 | Brain | 13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Ahnak2 (AHNAK nucleoprotein 2) | Male and Female | 3 | 23 | Hematological System | 81.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| AHSA2 (AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| AHSP (alpha hemoglobin stabilizing protein) | Using a linear mixed model, differential expression with age was identified in AHSP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AI317395 (expressed sequence AI317395) | Male and Female | 2 | 26 | Lung | 6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| AI447881 (expressed sequence AI447881) | Male and Female | 2 | 26 | Lung | 6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| AI596487 (expressed sequence AI596487) | Male and Female | 5 | 25 | Skeletal Muscle | -1.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| AIF1 (allograft inflammatory factor 1) | Using a linear mixed model, differential expression with age was identified in AIF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AIFM1 (apoptosis-inducing factor, mitochondrion-associated, 1) | Using a linear mixed model, differential expression with age was identified in AIFM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AJUBA (ajuba LIM protein) | Using a linear mixed model, differential expression with age was identified in AJUBA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AK4P3 (adenylate kinase 4 pseudogene 3) | Gene expression showed a significant (p<E-3) increase in the expression of AK4P3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 54.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| AKAP7 (A kinase (PRKA) anchor protein 7) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| AKAP8 (A kinase (PRKA) anchor protein 8) | Using a linear mixed model, differential expression with age was identified in AKAP8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Akr1c18 (aldo-keto reductase family 1, member C18) | Male and Female | 4 | 15 | Cochlea | -20.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| AKR1C3 (aldo-keto reductase family 1, member C3) | Comparison of DNA methylation showed a significantly decreased methylation level of AKR1C3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -19.3 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| AKR1C3 (aldo-keto reductase family 1, member C3) | Using a linear mixed model, differential expression with age was identified in AKR1C3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AKR7A2 (aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)) | Using a linear mixed model, differential expression with age was identified in AKR7A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALAS1 (aminolevulinate, delta-, synthase 1) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ALAS1 (aminolevulinate, delta-, synthase 1) | Using a linear mixed model, differential expression with age was identified in ALAS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Alb (albumin) | Male and Female | 5 | 22 | Brain | 88.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Alcam (activated leukocyte cell adhesion molecule) | Male and Female | 3 | 23 | Hematological System | 15.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ALDH1A1 (aldehyde dehydrogenase 1 family, member A1) | Comparison of DNA methylation showed a significantly decreased methylation level of ALDH1A1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -30.3 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1) | Male and Female | 8 | 24 | Muscle | 6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ALDH1A2 (aldehyde dehydrogenase 1 family, member A2) | Using a linear mixed model, differential expression with age was identified in ALDH1A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALDH1L1 (aldehyde dehydrogenase 1 family, member L1) | Using a linear mixed model, differential expression with age was identified in ALDH1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALDH3B2 (aldehyde dehydrogenase 3 family, member B2) | Using a linear mixed model, differential expression with age was identified in ALDH3B2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALDH6A1 (aldehyde dehydrogenase 6 family, member A1) | Using a linear mixed model, differential expression with age was identified in ALDH6A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALDH9A1 (aldehyde dehydrogenase 9 family, member A1) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ALDOB (aldolase B, fructose-bisphosphate) | Using a linear mixed model, differential expression with age was identified in ALDOB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALG13 (ALG13, UDP-N-acetylglucosaminyltransferase subunit) | Gene expression showed a significant (p<E-3) decrease in the expression of ALG13 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -42.2 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ALOX15B (arachidonate 15-lipoxygenase, type B) | Using a linear mixed model, differential expression with age was identified in ALOX15B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Alox5 (arachidonate 5-lipoxygenase) | 5-LOX mRNA expression decreased in heart from age 2 to 22 month. | Male | 2 | 22 | Heart | 2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386) | ||
| Alox5 (arachidonate 5-lipoxygenase) | 5-LOX mRNA expression level increased in frontal cortex from age 2 to 22 month. | Male | 2 | 22 | Heart | 2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386) | ||
| Alox5 (arachidonate 5-lipoxygenase) | 5-LOX promoter-5’UTR DNA methylation increased in heart from age 2 to 22 month. | Male | 2 | 22 | Heart | 2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386) | ||
| Alox5 (arachidonate 5-lipoxygenase) | 5-LOX promoter-5’UTR DNA methylation increased in cerebellum from age 2 to 22 month. | Male | 2 | 22 | Cerebellum | 2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386) | ||
| ALOX5 (arachidonate 5-lipoxygenase) | Using a linear mixed model, differential expression with age was identified in ALOX5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALOX5AP (arachidonate 5-lipoxygenase-activating protein) | Using a linear mixed model, differential expression with age was identified in ALOX5AP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALPK1 (alpha-kinase 1) | Using a linear mixed model, differential expression with age was identified in ALPK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALPK2 (alpha-kinase 2) | Male and Female | 27 | 92 | Kidney | 20.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| ALPK3 (alpha-kinase 3) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ALS2CL (ALS2 C-terminal like) | Using a linear mixed model, differential expression with age was identified in ALS2CL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ALX4 (ALX homeobox 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ALX4 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| AMACR (alpha-methylacyl-CoA racemase) | Using a linear mixed model, differential expression with age was identified in AMACR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ammecr1l (AMME chromosomal region gene 1-like) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| AMOT (angiomotin) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| AMT (aminomethyltransferase) | Using a linear mixed model, differential expression with age was identified in AMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Amy1 (amylase 1, salivary) | Male and Female | 8 | 24 | Muscle | 12.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ANAPC11 (anaphase promoting complex subunit 11) | Using a linear mixed model, differential expression with age was identified in ANAPC11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANAPC4 (anaphase promoting complex subunit 4) | Gene expression showed a significant (p<E-3) decrease in the expression of ANAPC4 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -35.48 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ANAPC4 (anaphase promoting complex subunit 4) | Using a linear mixed model, differential expression with age was identified in ANAPC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANAPC5 (anaphase promoting complex subunit 5) | Using a linear mixed model, differential expression with age was identified in ANAPC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANGEL2 (angel homolog 2 (Drosophila)) | Gene expression showed a significant (p<E-3) decrease in the expression of ANGEL2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -65.28 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ANGEL2 (angel homolog 2 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in ANGEL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Angpt1 (angiopoietin 1) | Male and Female | 8 | 24 | Muscle | -16.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ANGPTL2 (angiopoietin-like 2) | Using a linear mixed model, differential expression with age was identified in ANGPTL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ank (progressive ankylosis) | Male and Female | 2 | 15 | Hippocampus | 1.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| ANK2 (ankyrin 2, neuronal) | Male and Female | 26 | 106 | Brain | -20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ANKAR (ankyrin and armadillo repeat containing) | Using a linear mixed model, differential expression with age was identified in ANKAR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKEF1 (ankyrin repeat and EF-hand domain containing 1) | Using a linear mixed model, differential expression with age was identified in ANKEF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKMY2 (ankyrin repeat and MYND domain containing 2) | Using a linear mixed model, differential expression with age was identified in ANKMY2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKRA2 (ankyrin repeat, family A (RFXANK-like), 2) | Using a linear mixed model, differential expression with age was identified in ANKRA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKRD13A (ankyrin repeat domain 13A) | Using a linear mixed model, differential expression with age was identified in ANKRD13A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKRD13D (ankyrin repeat domain 13 family, member D) | Using a linear mixed model, differential expression with age was identified in ANKRD13D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ankrd26 (ankyrin repeat domain 26) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ANKRD35 (ankyrin repeat domain 35) | Using a linear mixed model, differential expression with age was identified in ANKRD35 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKRD39 (ankyrin repeat domain 39) | Using a linear mixed model, differential expression with age was identified in ANKRD39 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) | Using a linear mixed model, differential expression with age was identified in ANKS1A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANKZF1 (ankyrin repeat and zinc finger domain containing 1) | Using a linear mixed model, differential expression with age was identified in ANKZF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANO10 (anoctamin 10) | Using a linear mixed model, differential expression with age was identified in ANO10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ANP32B (acidic (leucine-rich) nuclear phosphoprotein 32 family, member B) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Antxr2 (anthrax toxin receptor 2) | Male and Female | 3 | 23 | Hematological System | -15.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Anxa2 (annexin A2) | Male and Female | 2 | 15 | Hippocampus | 8.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Anxa3 (annexin A3) | Male and Female | 5 | 25 | Skeletal Muscle | 23.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ANXA4 (annexin A4) | Male and Female | 26 | 106 | Brain | 11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| AP1G2 (adaptor-related protein complex 1, gamma 2 subunit) | Using a linear mixed model, differential expression with age was identified in AP1G2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AP1S1 (adaptor-related protein complex 1, sigma 1 subunit) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| AP1S2 (adaptor-related protein complex 1, sigma 2 subunit) | Using a linear mixed model, differential expression with age was identified in AP1S2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ap2m1 (adaptor protein complex AP-2, mu1) | Male and Female | 6 | 22 | Liver | 1.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| AP2S1 (adaptor-related protein complex 2, sigma 1 subunit) | Using a linear mixed model, differential expression with age was identified in AP2S1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AP4B1 (adaptor-related protein complex 4, beta 1 subunit) | Using a linear mixed model, differential expression with age was identified in AP4B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AP5S1 (adaptor-related protein complex 5, sigma 1 subunit) | Using a linear mixed model, differential expression with age was identified in AP5S1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APAF1 (apoptotic peptidase activating factor 1) | Using a linear mixed model, differential expression with age was identified in APAF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APBB1IP (amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein) | Male and Female | 27 | 92 | Kidney | 23.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| APBB3 (amyloid beta (A4) precursor protein-binding, family B, member 3) | Using a linear mixed model, differential expression with age was identified in APBB3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APCDD1L (adenomatosis polyposis coli down-regulated 1-like) | Using a linear mixed model, differential expression with age was identified in APCDD1L in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APEH (acylaminoacyl-peptide hydrolase) | Using a linear mixed model, differential expression with age was identified in APEH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APEH (acylaminoacyl-peptide hydrolase) | Using a linear mixed model, differential expression with age was identified in APEH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APH1B (APH1B gamma secretase subunit) | Using a linear mixed model, differential expression with age was identified in APH1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Apln (apelin) | Male and Female | 3 | 23 | Hematological System | 13.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| APMAP (adipocyte plasma membrane associated protein) | Using a linear mixed model, differential expression with age was identified in APMAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APOA1BP (apolipoprotein A-I binding protein) | Using a linear mixed model, differential expression with age was identified in APOA1BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Apobec1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1) | Male and Female | 5 | 22 | Brain | 92.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Apod (apolipoprotein D) | Male and Female | 5 | 30 | Anatomical System | 14.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| APOD (apolipoprotein D) | Male and Female | 26 | 106 | Brain | 14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| APOE (apolipoprotein E) | Methylation level of APOE in individuals 30 years of age apart decreased by 10.6% in the brain. | Male and Female | 63 | 92 | Prefrontal Cortex | 2707: Wang et al. (2008) "Age-specific epigenetic drift in late-onset Alzheimer's disease." PLoS ONE 3(7):e2698 (18628954) | ||
| APOLD1 (apolipoprotein L domain containing 1) | Using a linear mixed model, differential expression with age was identified in APOLD1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APOO (apolipoprotein O) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396) | |
| APPL1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| APRT (adenine phosphoribosyltransferase) | Using a linear mixed model, differential expression with age was identified in APRT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| APRT (adenine phosphoribosyltransferase) | Using a linear mixed model, differential expression with age was identified in APRT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARG2 (arginase 2) | Using a linear mixed model, differential expression with age was identified in ARG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARGLU1 (arginine and glutamate rich 1) | Using a linear mixed model, differential expression with age was identified in ARGLU1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARHGAP15 (Rho GTPase activating protein 15) | Using a linear mixed model, differential expression with age was identified in ARHGAP15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Arhgap18 (Rho GTPase activating protein 18) | Male and Female | 2 | 26 | Lung | 5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Arhgap26 (Rho GTPase activating protein 26) | Male and Female | 2 | 26 | Lung | 2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ARHGAP33 (Rho GTPase activating protein 33) | Using a linear mixed model, differential expression with age was identified in ARHGAP33 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARHGAP33 (Rho GTPase activating protein 33) | Using a linear mixed model, differential expression with age was identified in ARHGAP33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Arhgdia (Rho GDP dissociation inhibitor (GDI) alpha) | Male and Female | 6 | 22 | Liver | 9.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| ARHGEF10 (Rho guanine nucleotide exchange factor (GEF) 10) | Using a linear mixed model, differential expression with age was identified in ARHGEF10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARHGEF37 (Rho guanine nucleotide exchange factor (GEF) 37) | Using a linear mixed model, differential expression with age was identified in ARHGEF37 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARHGEF4 (Rho guanine nucleotide exchange factor (GEF) 4) | Using a linear mixed model, differential expression with age was identified in ARHGEF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARID1A (AT rich interactive domain 1A (SWI-like)) | Gene expression showed a significant (p<E-3) increase in the expression of ARID1A in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 51.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ARID1A (AT rich interactive domain 1A (SWI-like)) | Gene expression showed a significant (p<E-3) increase in the expression of ARID1A in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 103.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ARID4B (AT rich interactive domain 4B (RBP1-like)) | Using a linear mixed model, differential expression with age was identified in ARID4B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) | Using a linear mixed model, differential expression with age was identified in ARIH2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Arl1 (ADP-ribosylation factor-like 1) | Male and Female | 5 | 25 | Skeletal Muscle | 6.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ARL4A (ADP-ribosylation factor-like 4A) | Using a linear mixed model, differential expression with age was identified in ARL4A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARL4A (ADP-ribosylation factor-like 4A) | Using a linear mixed model, differential expression with age was identified in ARL4A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Arl5a (ADP-ribosylation factor-like 5A) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ARL6IP6 (ADP-ribosylation-like factor 6 interacting protein 6) | Gene expression showed a significant (p<E-3) decrease in the expression of ARL6IP6 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -76.13 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ARMC6 (armadillo repeat containing 6) | Using a linear mixed model, differential expression with age was identified in ARMC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Armcx1 (armadillo repeat containing, X-linked 1) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ARNTL (aryl hydrocarbon receptor nuclear translocator-like) | Using a linear mixed model, differential expression with age was identified in ARNTL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARPC2 (actin related protein 2/3 complex, subunit 2, 34kDa) | Using a linear mixed model, differential expression with age was identified in ARPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARPC5L (actin related protein 2/3 complex, subunit 5-like) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ARPIN (actin-related protein 2/3 complex inhibitor) | Using a linear mixed model, differential expression with age was identified in C15orf38 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARRDC4 (arrestin domain containing 4) | Using a linear mixed model, differential expression with age was identified in ARRDC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARSA (arylsulfatase A) | Male and Female | 26 | 106 | Brain | 17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ARSF (arylsulfatase F) | Using a linear mixed model, differential expression with age was identified in ARSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ARSG (arylsulfatase G) | Comparison of DNA methylation showed a significantly increased methylation level of ARSG in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 19.6 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2) | Using a linear mixed model, differential expression with age was identified in ASAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASB13 (ankyrin repeat and SOCS box containing 13) | Using a linear mixed model, differential expression with age was identified in ASB13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASCL2 (achaete-scute family bHLH transcription factor 2) | Using a linear mixed model, differential expression with age was identified in ASCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASIC2 (acid-sensing (proton-gated) ion channel 2) | Using a linear mixed model, differential expression with age was identified in ASIC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ASNS (asparagine synthetase (glutamine-hydrolyzing)) | Using a linear mixed model, differential expression with age was identified in ASNS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASPA (aspartoacylase) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ASPA and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ASPM (asp (abnormal spindle) homolog, microcephaly associated (Drosophila)) | Using a linear mixed model, differential expression with age was identified in ASPM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ASUN (asunder spermatogenesis regulator) | Using a linear mixed model, differential expression with age was identified in ASUN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATF6 (activating transcription factor 6) | Using a linear mixed model, differential expression with age was identified in ATF6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATF6 (activating transcription factor 6) | Using a linear mixed model, differential expression with age was identified in ATF6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Atg12 (autophagy-related 12 (yeast)) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ATG16L2 (autophagy related 16-like 2 (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in ATG16L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATG4A (autophagy related 4A, cysteine peptidase) | Using a linear mixed model, differential expression with age was identified in ATG4A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Atg5 (autophagy-related 5 (yeast)) | Male and Female | 6 | 22 | Liver | -7.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Atg9b (ATG9 autophagy related 9 homolog B (S. cerevisiae)) | Male and Female | 3 | 23 | Hematological System | 7.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ATL3 (atlastin GTPase 3) | Using a linear mixed model, differential expression with age was identified in ATL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATOX1 (antioxidant 1 copper chaperone) | Using a linear mixed model, differential expression with age was identified in ATOX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Atp1b2 (ATPase, Na+/K+ transporting, beta 2 polypeptide) | Male and Female | 5 | 30 | Anatomical System | 4.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP2B2 (ATPase, Ca++ transporting, plasma membrane 2) | Male and Female | 26 | 106 | Brain | -23.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP5A1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP5B (ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP5C1 (ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ATP5D (ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit) | Using a linear mixed model, differential expression with age was identified in ATP5D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP5G1 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ATP5G3 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Atp5j2 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Atp5l (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g) | Male and Female | 8 | 24 | Muscle | -1.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ATP5O (ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ATP5SL (ATP5S-like) | Using a linear mixed model, differential expression with age was identified in ATP5SL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V0A4 (ATPase, H+ transporting, lysosomal V0 subunit a4) | Using a linear mixed model, differential expression with age was identified in ATP6V0A4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V0B (ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b) | Using a linear mixed model, differential expression with age was identified in ATP6V0B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V0C (ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c) | Using a linear mixed model, differential expression with age was identified in ATP6V0C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1) | Using a linear mixed model, differential expression with age was identified in ATP6V0D1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V0E1 (ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1) | Using a linear mixed model, differential expression with age was identified in ATP6V0E1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V1A (ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ATP6V1C1 (ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1) | Using a linear mixed model, differential expression with age was identified in ATP6V1C1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V1D (ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D) | Using a linear mixed model, differential expression with age was identified in ATP6V1D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Atp7a (ATPase, Cu++ transporting, alpha polypeptide) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ATPAF1 (ATP synthase mitochondrial F1 complex assembly factor 1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ATPIF1 (ATPase inhibitory factor 1) | Using a linear mixed model, differential expression with age was identified in ATPIF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ATXN1 (ataxin 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Atxn2 (ataxin 2) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| AU020206 (expressed sequence AU020206) | Male and Female | 2 | 15 | Hippocampus | 10.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Aurkc (aurora kinase C) | Male and Female | 5 | 22 | Brain | -65.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| AUTS2 (autism susceptibility candidate 2) | Using a linear mixed model, differential expression with age was identified in AUTS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AUTS2 (autism susceptibility candidate 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of AUTS2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Avpi1 (arginine vasopressin-induced 1) | Male and Female | 3 | 23 | Hematological System | 15.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| AWAT1 (acyl-CoA wax alcohol acyltransferase 1) | Using a linear mixed model, differential expression with age was identified in AWAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AWAT2 (acyl-CoA wax alcohol acyltransferase 2) | Using a linear mixed model, differential expression with age was identified in AWAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AXDND1 (axonemal dynein light chain domain containing 1) | Using a linear mixed model, differential expression with age was identified in AXDND1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| AZIN1 (antizyme inhibitor 1) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| B230312A22Rik (RIKEN cDNA B230312A22 gene) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| B2m (beta-2 microglobulin) | Male and Female | 2 | 15 | Hippocampus | 6.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)) | Male and Female | 26 | 106 | Brain | -22.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| B3galt1 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1) | Male and Female | 3 | 23 | Hematological System | 36.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| B4galnt4 (beta-1,4-N-acetyl-galactosaminyl transferase 4) | Male and Female | 3 | 23 | Hematological System | 11.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| BAG2 (BCL2-associated athanogene 2) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| BATF3 (basic leucine zipper transcription factor, ATF-like 3) | Using a linear mixed model, differential expression with age was identified in BATF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BAZ1A (bromodomain adjacent to zinc finger domain, 1A) | Using a linear mixed model, differential expression with age was identified in BAZ1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BAZ2B (bromodomain adjacent to zinc finger domain, 2B) | Using a linear mixed model, differential expression with age was identified in BAZ2B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BBOX1 (butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1) | Using a linear mixed model, differential expression with age was identified in BBOX1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BBS2 (Bardet-Biedl syndrome 2) | Using a linear mixed model, differential expression with age was identified in BBS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BBS4 (Bardet-Biedl syndrome 4) | Using a linear mixed model, differential expression with age was identified in BBS4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BC017643 (cDNA sequence BC017643) | Male and Female | 3 | 23 | Hematological System | -9.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| BC026782 (cDNA sequence BC026782) | Male and Female | 5 | 22 | Brain | 217.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| BC037703 (cDNA sequence BC037703) | Male and Female | 5 | 22 | Brain | 809.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| BC048546 (cDNA sequence BC048546) | Male and Female | 2 | 26 | Lung | 18.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| BCAN (brevican) | Using a linear mixed model, differential expression with age was identified in BCAN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCAP29 (B-cell receptor-associated protein 29) | Using a linear mixed model, differential expression with age was identified in BCAP29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Bcap31 (B-cell receptor-associated protein 31) | Male and Female | 5 | 25 | Skeletal Muscle | 4.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| BCAS3 (breast carcinoma amplified sequence 3) | Using a linear mixed model, differential expression with age was identified in BCAS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCAT2 (branched chain amino-acid transaminase 2, mitochondrial) | Using a linear mixed model, differential expression with age was identified in BCAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCKDHB (branched chain keto acid dehydrogenase E1, beta polypeptide) | Using a linear mixed model, differential expression with age was identified in BCKDHB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCKDK (branched chain ketoacid dehydrogenase kinase) | Using a linear mixed model, differential expression with age was identified in BCKDK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCL11A (B-cell CLL/lymphoma 11A (zinc finger protein)) | Male and Female | 26 | 106 | Brain | -14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| BCL11A (B-cell CLL/lymphoma 11A (zinc finger protein)) | Using a linear mixed model, differential expression with age was identified in BCL11A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Bcl3 (B-cell leukemia/lymphoma 3) | Male and Female | 3 | 23 | Hematological System | 25.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| BCL6 (B-cell CLL/lymphoma 6) | Using a linear mixed model, differential expression with age was identified in BCL6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCL6 (B-cell CLL/lymphoma 6) | Using a linear mixed model, differential expression with age was identified in BCL6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BCO1 (beta-carotene oxygenase 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BCMO1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| BCS1L (BCS1-like (yeast)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| BDH1 (3-hydroxybutyrate dehydrogenase, type 1) | Using a linear mixed model, differential expression with age was identified in BDH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Bdnf (brain derived neurotrophic factor) | Male and Female | 5 | 25 | Skeletal Muscle | 5.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Bdp1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| BEX1 (brain expressed, X-linked 1) | Using a linear mixed model, differential expression with age was identified in BEX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BHLHE22 (basic helix-loop-helix family, member e22) | Using a linear mixed model, differential expression with age was identified in BHLHE22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BHLHE40 (basic helix-loop-helix family, member e40) | Using a linear mixed model, differential expression with age was identified in BHLHE40 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BICC1 (BicC family RNA binding protein 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of BICC1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| BID (BH3 interacting domain death agonist) | Using a linear mixed model, differential expression with age was identified in BID in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BIRC6 (baculoviral IAP repeat containing 6) | Using a linear mixed model, differential expression with age was identified in BIRC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Birc6 (baculoviral IAP repeat-containing 6) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| BLCAP (bladder cancer associated protein) | Using a linear mixed model, differential expression with age was identified in BLCAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BLOC1S2 (biogenesis of lysosomal organelles complex-1, subunit 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BLOC1S2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| BMP6 (bone morphogenetic protein 6) | Using a linear mixed model, differential expression with age was identified in BMP6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BMP7 (bone morphogenetic protein 7) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| BMPR1B (bone morphogenetic protein receptor, type IB) | Male and Female | 22 | 73 | Skeletal Muscle | -11.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| BMS1 (BMS1 ribosome biogenesis factor) | Using a linear mixed model, differential expression with age was identified in BMS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BMX (BMX non-receptor tyrosine kinase) | Using a linear mixed model, differential expression with age was identified in BMX in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BOC (BOC cell adhesion associated, oncogene regulated) | Using a linear mixed model, differential expression with age was identified in BOC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BOK (BCL2-related ovarian killer) | Using a linear mixed model, differential expression with age was identified in BOK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BOLA3 (bolA homolog 3 (E. coli)) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Bptf (bromodomain PHD finger transcription factor) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| BRD8 (bromodomain containing 8) | Using a linear mixed model, differential expression with age was identified in BRD8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BRE (brain and reproductive organ-expressed (TNFRSF1A modulator)) | Using a linear mixed model, differential expression with age was identified in BRE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BRI3BP (BRI3 binding protein) | Using a linear mixed model, differential expression with age was identified in BRI3BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Brms1l (breast cancer metastasis-suppressor 1-like) | Male and Female | 2 | 26 | Lung | -1.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| BRP44L (brain protein 44-like) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| BRP44L (brain protein 44-like) | Male and Female | 27 | 92 | Kidney | -9.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)) | Using a linear mixed model, differential expression with age was identified in BSCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BSG (basigin (Ok blood group)) | Using a linear mixed model, differential expression with age was identified in BSG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BST2 (bone marrow stromal cell antigen 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BST2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| BTBD11 (BTB (POZ) domain containing 11) | Using a linear mixed model, differential expression with age was identified in BTBD11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BTBD2 (BTB (POZ) domain containing 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BTBD2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| BTBD3 (BTB (POZ) domain containing 3) | Using a linear mixed model, differential expression with age was identified in BTBD3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BTBD6 (BTB (POZ) domain containing 6) | Using a linear mixed model, differential expression with age was identified in BTBD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BTD (biotinidase) | Using a linear mixed model, differential expression with age was identified in BTD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BTN2A1 (butyrophilin, subfamily 2, member A1) | Using a linear mixed model, differential expression with age was identified in BTN2A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| BTNL3 (butyrophilin-like 3) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| BUD31 (BUD31 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in BUD31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C10orf35 (chromosome 10 open reading frame 35) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C10orf35 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| C10orf82 (chromosome 10 open reading frame 82) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of C10orf82 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| C11orf45 (chromosome 11 open reading frame 45) | Using a linear mixed model, differential expression with age was identified in C11orf45 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C11orf70 (chromosome 11 open reading frame 70) | Using a linear mixed model, differential expression with age was identified in C11orf70 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C11orf73 (chromosome 11 open reading frame 73) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C11orf74 (chromosome 11 open reading frame 74) | Using a linear mixed model, differential expression with age was identified in C11orf74 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C12orf65 (chromosome 12 open reading frame 65) | Using a linear mixed model, differential expression with age was identified in C12orf65 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C130026I21Rik (RIKEN cDNA C130026I21 gene) | Male and Female | 2 | 26 | Lung | 27.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| C130026I21Rik (RIKEN cDNA C130026I21 gene) | Male and Female | 3 | 23 | Hematological System | 22.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| C14orf132 (chromosome 14 open reading frame 132) | Using a linear mixed model, differential expression with age was identified in C14orf132 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C14orf177 (chromosome 14 open reading frame 177) | Comparison of DNA methylation showed a significantly decreased methylation level of C14orf177 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.2 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| C14orf177 (chromosome 14 open reading frame 177) | Comparison of DNA methylation showed a significantly increased methylation level of C14orf177 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 42.5 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| C14orf2 (chromosome 14 open reading frame 2) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C14orf2 (chromosome 14 open reading frame 2) | Using a linear mixed model, differential expression with age was identified in C14orf2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C14orf28 (chromosome 14 open reading frame 28) | Using a linear mixed model, differential expression with age was identified in C14orf28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C15orf27 (chromosome 15 open reading frame 27) | Using a linear mixed model, differential expression with age was identified in C15orf27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C15orf59 (chromosome 15 open reading frame 59) | Using a linear mixed model, differential expression with age was identified in C15orf59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C16orf61 (chromosome 16 open reading frame 61) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C17orf49 (chromosome 17 open reading frame 49) | Using a linear mixed model, differential expression with age was identified in C17orf49 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C18orf19 (chromosome 18 open reading frame 19) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C19orf10 (chromosome 19 open reading frame 10) | Using a linear mixed model, differential expression with age was identified in C19orf10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C19orf24 (chromosome 19 open reading frame 24) | Using a linear mixed model, differential expression with age was identified in C19orf24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1orf122 (chromosome 1 open reading frame 122) | Using a linear mixed model, differential expression with age was identified in C1orf122 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1orf158 (chromosome 1 open reading frame 158) | Using a linear mixed model, differential expression with age was identified in C1orf158 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1orf162 (chromosome 1 open reading frame 162) | Male and Female | 27 | 92 | Kidney | 37.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| C1orf21 (chromosome 1 open reading frame 21) | Using a linear mixed model, differential expression with age was identified in C1orf21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1orf64 (chromosome 1 open reading frame 64) | Using a linear mixed model, differential expression with age was identified in C1orf64 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1orf95 (chromosome 1 open reading frame 95) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| C1QA (complement component 1, q subcomponent, A chain) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 243.36 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QA (complement component 1, q subcomponent, A chain) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 154.93 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QA (complement component 1, q subcomponent, A chain) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 98.36 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QA (complement component 1, q subcomponent, A chain) | Using a linear mixed model, differential expression with age was identified in C1QA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1qa (complement component 1, q subcomponent, alpha polypeptide) | Male and Female | 5 | 30 | Anatomical System | 5.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| C1QB (complement component 1, q subcomponent, B chain) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 186.74 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QB (complement component 1, q subcomponent, B chain) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 391.36 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QB (complement component 1, q subcomponent, B chain) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 288.08 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QB (complement component 1, q subcomponent, B chain) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 166.75 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QB (complement component 1, q subcomponent, B chain) | Using a linear mixed model, differential expression with age was identified in C1QB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1qb (complement component 1, q subcomponent, beta polypeptide) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| C1QC (complement component 1, q subcomponent, C chain) | Male and Female | 27 | 92 | Kidney | 27.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| C1qc (complement component 1, q subcomponent, C chain) | Male and Female | 5 | 30 | Anatomical System | 5.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| C1qc (complement component 1, q subcomponent, C chain) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| C1QC (complement component 1, q subcomponent, C chain) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 154.27 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QC (complement component 1, q subcomponent, C chain) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 323.41 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QC (complement component 1, q subcomponent, C chain) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 216.18 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QC (complement component 1, q subcomponent, C chain) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 126.06 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1QC (complement component 1, q subcomponent, C chain) | Using a linear mixed model, differential expression with age was identified in C1QC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1QTNF1 (C1q and tumor necrosis factor related protein 1) | Using a linear mixed model, differential expression with age was identified in C1QTNF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1qtnf2 (C1q and tumor necrosis factor related protein 2) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| C1qtnf3 (C1q and tumor necrosis factor related protein 3) | Male and Female | 2 | 26 | Lung | -22.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| C1QTNF5 (C1q and tumor necrosis factor related protein 5) | Using a linear mixed model, differential expression with age was identified in C1QTNF5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1QTNF6 (C1q and tumor necrosis factor related protein 6) | Using a linear mixed model, differential expression with age was identified in C1QTNF6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C1R (complement component 1, r subcomponent) | Male and Female | 20 | 75 | Skeletal Muscle | 8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C1R (complement component 1, r subcomponent) | Male and Female | 27 | 92 | Kidney | 21.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| C1S (complement component 1, s subcomponent) | Male and Female | 27 | 92 | Kidney | 24.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| C1S (complement component 1, s subcomponent) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C1S (complement component 1, s subcomponent) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 152.93 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1S (complement component 1, s subcomponent) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 105.32 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1S (complement component 1, s subcomponent) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 54.03 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1S (complement component 1, s subcomponent) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 60.37 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C1S (complement component 1, s subcomponent) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 71.93 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C20orf24 (chromosome 20 open reading frame 24) | Using a linear mixed model, differential expression with age was identified in C20orf24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C21orf33 (chromosome 21 open reading frame 33) | Using a linear mixed model, differential expression with age was identified in C21orf33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C2orf88 (chromosome 2 open reading frame 88) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C3 (complement component 3) | Male and Female | 6 | 22 | Liver | 5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| C3 (complement component 3) | Male and Female | 20 | 75 | Skeletal Muscle | 16.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C3 (complement component 3) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 201.58 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C3 (complement component 3) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 108.42 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C3AR1 (complement component 3a receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 196.97 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C3AR1 (complement component 3a receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 134.8 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C3AR1 (complement component 3a receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 89.04 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C3orf18 (chromosome 3 open reading frame 18) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C3orf18 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| C4A (complement component 4A (Rodgers blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 115.31 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4A (complement component 4A (Rodgers blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 226.29 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4A (complement component 4A (Rodgers blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 216.42 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4A (complement component 4A (Rodgers blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 153.8 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4A (complement component 4A (Rodgers blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 187.29 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4a (complement component 4A (Rodgers blood group)) | Male and Female | 5 | 30 | Anatomical System | 26.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| C4B (complement component 4B (Chido blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 289.92 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4B (complement component 4B (Chido blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 466.15 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4B (complement component 4B (Chido blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 444.8 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4B (complement component 4B (Chido blood group)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 895.88 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C4orf17 (chromosome 4 open reading frame 17) | Male and Female | 20 | 75 | Skeletal Muscle | -13.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C5 (complement component 5) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 35.31 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C5 (complement component 5) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 43.68 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C5AR1 (complement component 5a receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C5AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 166.23 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C5AR1 (complement component 5a receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C5AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 34.3 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| C5orf13 (chromosome 5 open reading frame 13) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| C5orf30 (chromosome 5 open reading frame 30) | Male and Female | 26 | 106 | Brain | -19.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| C6orf106 (chromosome 6 open reading frame 106) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| C6orf106 (chromosome 6 open reading frame 106) | Using a linear mixed model, differential expression with age was identified in C6orf106 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C6orf136 (chromosome 6 open reading frame 136) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C6orf52 (chromosome 6 open reading frame 52) | Using a linear mixed model, differential expression with age was identified in C6orf52 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C78197 (expressed sequence C78197) | Male and Female | 5 | 25 | Skeletal Muscle | 16.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| C78339 (expressed sequence C78339) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| C7orf44 (chromosome 7 open reading frame 44) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C8orf44 (chromosome 8 open reading frame 44) | Using a linear mixed model, differential expression with age was identified in C8orf44 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| C9orf123 (chromosome 9 open reading frame 123) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| C9orf139 (chromosome 9 open reading frame 139) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C9orf139 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| C9orf16 (chromosome 9 open reading frame 16) | Using a linear mixed model, differential expression with age was identified in C9orf16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CA11 (carbonic anhydrase XI) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CA12 (carbonic anhydrase XII) | Using a linear mixed model, differential expression with age was identified in CA12 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CA12 (carbonic anhydrase XII) | Using a linear mixed model, differential expression with age was identified in CA12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CA14 (carbonic anhydrase XIV) | Using a linear mixed model, differential expression with age was identified in CA14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CA4 (carbonic anhydrase IV) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CA9 (carbonic anhydrase IX) | Using a linear mixed model, differential expression with age was identified in CA9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CACFD1 (calcium channel flower domain containing 1) | Using a linear mixed model, differential expression with age was identified in CACFD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit) | Using a linear mixed model, differential expression with age was identified in CACNA1F in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CACNB2 (calcium channel, voltage-dependent, beta 2 subunit) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CADM2 (cell adhesion molecule 2) | Using a linear mixed model, differential expression with age was identified in CADM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CADM3 (cell adhesion molecule 3) | Using a linear mixed model, differential expression with age was identified in CADM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALB1 (calbindin 1, 28kDa) | Male and Female | 26 | 106 | Brain | -58.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CALD1 (caldesmon 1) | Using a linear mixed model, differential expression with age was identified in CALD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALM1 (calmodulin 1 (phosphorylase kinase, delta)) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CALM3 (calmodulin 3 (phosphorylase kinase, delta)) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CALML3 (calmodulin-like 3) | Using a linear mixed model, differential expression with age was identified in CALML3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALML4 (calmodulin-like 4) | Using a linear mixed model, differential expression with age was identified in CALML4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALR (calreticulin) | Using a linear mixed model, differential expression with age was identified in CALR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALU (calumenin) | Using a linear mixed model, differential expression with age was identified in CALU in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CALY (calcyon neuron-specific vesicular protein) | Using a linear mixed model, differential expression with age was identified in CALY in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Camk1d (calcium/calmodulin-dependent protein kinase ID) | Male and Female | 2 | 26 | Lung | 6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Camk2b (calcium/calmodulin-dependent protein kinase II, beta) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CAMK2G (calcium/calmodulin-dependent protein kinase II gamma) | Using a linear mixed model, differential expression with age was identified in CAMK2G in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CAMK4 (calcium/calmodulin-dependent protein kinase IV) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, beta) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CANX (calnexin) | Using a linear mixed model, differential expression with age was identified in CANX in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CAPG (capping protein (actin filament), gelsolin-like) | Comparison of DNA methylation showed a significantly decreased methylation level of CAPG in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -20.1 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CAPG (capping protein (actin filament), gelsolin-like) | Comparison of DNA methylation showed a significantly decreased methylation level of CAPG in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -19.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CAPN13 (calpain 13) | Using a linear mixed model, differential expression with age was identified in CAPN13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CAPNS1 (calpain, small subunit 1) | Using a linear mixed model, differential expression with age was identified in CAPNS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CAPRIN2 (caprin family member 2) | Using a linear mixed model, differential expression with age was identified in CAPRIN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CAPS (calcyphosine) | Comparison of DNA methylation showed a significantly decreased methylation level of CAPS in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -28.0 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CAPS (calcyphosine) | Comparison of DNA methylation showed a significantly decreased methylation level of CAPS in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -17.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Car2 (carbonic anhydrase 2) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Card10 (caspase recruitment domain family, member 10) | Male and Female | 3 | 23 | Hematological System | 19.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CARHSP1 (calcium regulated heat stable protein 1, 24kDa) | Using a linear mixed model, differential expression with age was identified in CARHSP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CASC1 (cancer susceptibility candidate 1) | Using a linear mixed model, differential expression with age was identified in CASC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 30.21 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 165.49 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 101.82 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 102.73 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 91.77 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 137.32 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 41.97 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 40.31 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 28.41 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 43.44 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASP1 (caspase 1, apoptosis-related cysteine peptidase) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 53.3 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CASQ2 (calsequestrin 2 (cardiac muscle)) | Using a linear mixed model, differential expression with age was identified in CASQ2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Catsper1 (cation channel, sperm associated 1) | Male and Female | 8 | 24 | Muscle | -10.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CATSPERG (catsper channel auxiliary subunit gamma) | Using a linear mixed model, differential expression with age was identified in CATSPERG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cav1 (caveolin 1, caveolae protein) | Male and Female | 5 | 22 | Brain | 6.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| CBS (cystathionine-beta-synthase) | Male and Female | 26 | 106 | Brain | 18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CBX7 (chromobox homolog 7) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CBX7 (chromobox homolog 7) | Using a linear mixed model, differential expression with age was identified in CBX7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CBX7 (chromobox homolog 7) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CBX7 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Ccbe1 (collagen and calcium binding EGF domains 1) | Male and Female | 3 | 23 | Hematological System | 57.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CCBL1 (cysteine conjugate-beta lyase, cytoplasmic) | Using a linear mixed model, differential expression with age was identified in CCBL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC105 (coiled-coil domain containing 105) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CCDC105 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CCDC130 (coiled-coil domain containing 130) | Using a linear mixed model, differential expression with age was identified in CCDC130 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC14 (coiled-coil domain containing 14) | Using a linear mixed model, differential expression with age was identified in CCDC14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC146 (coiled-coil domain containing 146) | Using a linear mixed model, differential expression with age was identified in CCDC146 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC167 (coiled-coil domain containing 167) | Using a linear mixed model, differential expression with age was identified in CCDC167 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC174 (coiled-coil domain containing 174) | Using a linear mixed model, differential expression with age was identified in CCDC174 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC3 (coiled-coil domain containing 3) | Male and Female | 27 | 92 | Kidney | 19.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| CCDC3 (coiled-coil domain containing 3) | Using a linear mixed model, differential expression with age was identified in CCDC3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC46 (coiled-coil domain containing 46) | Male and Female | 26 | 106 | Brain | 86.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CCDC72 (coiled-coil domain containing 72) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CCDC85A (coiled-coil domain containing 85A) | Using a linear mixed model, differential expression with age was identified in CCDC85A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCDC86 (coiled-coil domain containing 86) | Using a linear mixed model, differential expression with age was identified in CCDC86 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCK (cholecystokinin) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CCKBR (cholecystokinin B receptor) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CCL2 (chemokine (C-C motif) ligand 2) | Using a linear mixed model, differential expression with age was identified in CCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCL21 (chemokine (C-C motif) ligand 21) | Using a linear mixed model, differential expression with age was identified in CCL21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ccl21b (chemokine (C-C motif) ligand 21B) | Male and Female | 5 | 30 | Anatomical System | 51.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| CCL23 (chemokine (C-C motif) ligand 23) | Using a linear mixed model, differential expression with age was identified in CCL23 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCL28 (chemokine (C-C motif) ligand 28) | Using a linear mixed model, differential expression with age was identified in CCL28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ccnf (cyclin F) | Male and Female | 6 | 22 | Liver | -3.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CCNF (cyclin F) | Using a linear mixed model, differential expression with age was identified in CCNF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CCR1 (chemokine (C-C motif) receptor 1) | Comparison of DNA methylation showed a significantly decreased methylation level of CCR1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.5 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CCR1 (chemokine (C-C motif) receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 93.8 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CCR1 (chemokine (C-C motif) receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 53.94 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CCR1 (chemokine (C-C motif) receptor 1) | Comparison of DNA methylation showed a significantly increased methylation level of CCR1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 31.2 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CCR1 (chemokine (C-C motif) receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 182.46 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CCR1 (chemokine (C-C motif) receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 129.18 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CCRN4L (CCR4 carbon catabolite repression 4-like (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in CCRN4L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cct5 (chaperonin containing Tcp1, subunit 5 (epsilon)) | Male and Female | 6 | 22 | Liver | 7.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CD14 (CD14 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 154.26 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD14 (CD14 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 395.01 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD14 (CD14 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 186.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD14 (CD14 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 134.89 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD14 (CD14 molecule) | Using a linear mixed model, differential expression with age was identified in CD14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cd160 (CD160 antigen) | Male and Female | 8 | 24 | Muscle | -6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Cd163 (CD163 antigen) | Male and Female | 2 | 26 | Lung | 28.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 515.74 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 552.3 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 488.09 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 491.51 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 283.01 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163 (CD163 molecule) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 383.1 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CD163L1 (CD163 molecule-like 1) | Using a linear mixed model, differential expression with age was identified in CD163L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD164L2 (CD164 sialomucin-like 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CD164L2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CD1B (CD1b molecule) | Using a linear mixed model, differential expression with age was identified in CD1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD1C (CD1c molecule) | Using a linear mixed model, differential expression with age was identified in CD1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD207 (CD207 molecule, langerin) | Male and Female | 20 | 75 | Skeletal Muscle | -7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CD209 (CD209 molecule) | Using a linear mixed model, differential expression with age was identified in CD209 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD274 (CD274 molecule) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CD274 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Cd28 (CD28 antigen) | Male and Female | 2 | 26 | Lung | 17.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CD2BP2 (CD2 (cytoplasmic tail) binding protein 2) | Using a linear mixed model, differential expression with age was identified in CD2BP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD300A (CD300a molecule) | Using a linear mixed model, differential expression with age was identified in CD300A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CD34 (CD34 molecule) | Comparison of DNA methylation showed a significantly decreased methylation level of CD34 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.6 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CD34 (CD34 molecule) | Comparison of DNA methylation showed a significantly decreased methylation level of CD34 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -17.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Cd38 (CD38 antigen) | Male and Female | 4 | 15 | Cochlea | 26.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| CD4 (CD4 molecule) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of CD4 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| CD79B (CD79b molecule, immunoglobulin-associated beta) | Using a linear mixed model, differential expression with age was identified in CD79B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cd8b1 (CD8 antigen, beta chain 1) | Male and Female | 2 | 26 | Lung | 36.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CDA (cytidine deaminase) | Using a linear mixed model, differential expression with age was identified in CDA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDC16 (cell division cycle 16) | Using a linear mixed model, differential expression with age was identified in CDC16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDC25C (cell division cycle 25C) | Using a linear mixed model, differential expression with age was identified in CDC25C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDC2L2 (cell division cycle 2-like 2 (PITSLRE proteins)) | Male and Female | 26 | 106 | Brain | 27.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CDC42EP3 (CDC42 effector protein (Rho GTPase binding) 3) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CDCP1 (CUB domain containing protein 1) | Using a linear mixed model, differential expression with age was identified in CDCP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDH12 (cadherin 12, type 2 (N-cadherin 2)) | Using a linear mixed model, differential expression with age was identified in CDH12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDH5 (cadherin 5, type 2 (vascular endothelium)) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Cdh6 (cadherin 6) | Male and Female | 2 | 15 | Hippocampus | -9.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| CDHR1 (cadherin-related family member 1) | Using a linear mixed model, differential expression with age was identified in CDHR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDK12 (cyclin-dependent kinase 12) | Male and Female | 26 | 106 | Brain | 17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CDK14 (cyclin-dependent kinase 14) | Using a linear mixed model, differential expression with age was identified in CDK14 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cdk18 (cyclin-dependent kinase 18) | Male and Female | 6 | 22 | Liver | -7.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CDK20 (cyclin-dependent kinase 20) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CDK20 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CDK3 (cyclin-dependent kinase 3) | Using a linear mixed model, differential expression with age was identified in CDK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDK5 (cyclin-dependent kinase 5) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CDK5R1 (cyclin-dependent kinase 5, regulatory subunit 1 (p35)) | Comparison of DNA methylation showed a significantly decreased methylation level of CDK5R1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.2 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CDK5RAP3 (CDK5 regulatory subunit associated protein 3) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CDK5RAP3 (CDK5 regulatory subunit associated protein 3) | Using a linear mixed model, differential expression with age was identified in CDK5RAP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDKL2 (cyclin-dependent kinase-like 2 (CDC2-related kinase)) | Using a linear mixed model, differential expression with age was identified in CDKL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21)) | Male and Female | 8 | 24 | Muscle | 14.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)) | Male and Female | 20 | 75 | Skeletal Muscle | 50.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)) | Using a linear mixed model, differential expression with age was identified in CDKN1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDKN1C (cyclin-dependent kinase inhibitor 1C (p57, Kip2)) | Gene expression showed a significant (p<E-3) decrease in the expression of CDKN1C in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -69.33 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| CDKN2A (cyclin-dependent kinase inhibitor 2A) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CDKN2A and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Cdkn2a (cyclin-dependent kinase inhibitor 2A) | p16 levels increase with aging in many tissues and is a marker of cellular senescence. | Male and Female | 1 | -1 | Whole Body | 1947: Krishnamurthy et al. (2006) "p16INK4a induces an age-dependent decline in islet regenerative potential." Nature 443(7110):453-457 (16957737)|1945: Molofsky et al. (2006) "Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing." Nature 443(7110):448-452 (16957738) | ||
| CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) | Comparison of DNA methylation showed a significantly decreased methylation level of CDKN2B in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -16.7 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) | Comparison of DNA methylation showed a significantly increased methylation level of CDKN2B in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 26.0 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CDPF1 (cysteine-rich, DPF motif domain containing 1) | Using a linear mixed model, differential expression with age was identified in CDPF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CDRT4 (CMT1A duplicated region transcript 4) | Using a linear mixed model, differential expression with age was identified in CDRT4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha) | Male and Female | 20 | 75 | Skeletal Muscle | 28.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha) | Using a linear mixed model, differential expression with age was identified in CEBPA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CEBPB (CCAAT/enhancer binding protein (C/EBP), beta) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Cebpd (CCAAT/enhancer binding protein (C/EBP), delta) | Male and Female | 3 | 23 | Hematological System | 39.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CECR1 (cat eye syndrome chromosome region, candidate 1) | Using a linear mixed model, differential expression with age was identified in CECR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cecr5 (cat eye syndrome chromosome region, candidate 5 homolog (human)) | Male and Female | 6 | 22 | Liver | 15.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CELF6 (CUGBP, Elav-like family member 6) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CELF6 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CENPJ (centromere protein J) | Using a linear mixed model, differential expression with age was identified in CENPJ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CENPM (centromere protein M) | Using a linear mixed model, differential expression with age was identified in CENPM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CENPV (centromere protein V) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CEP135 (centrosomal protein 135kDa) | Using a linear mixed model, differential expression with age was identified in CEP135 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CEP350 (centrosomal protein 350kDa) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CEP57 (centrosomal protein 57kDa) | Gene expression showed a significant (p<E-3) increase in the expression of CEP57 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 86.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| CEP63 (centrosomal protein 63kDa) | Using a linear mixed model, differential expression with age was identified in CEP63 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CEP95 (centrosomal protein 95kDa) | Using a linear mixed model, differential expression with age was identified in CEP95 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CERCAM (cerebral endothelial cell adhesion molecule) | Using a linear mixed model, differential expression with age was identified in CERCAM in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CERCAM (cerebral endothelial cell adhesion molecule) | Using a linear mixed model, differential expression with age was identified in CERCAM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CES4A (carboxylesterase 4A) | Using a linear mixed model, differential expression with age was identified in CES4A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CETN3 (centrin, EF-hand protein, 3) | Using a linear mixed model, differential expression with age was identified in CETN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CFAP69 (cilia and flagella associated protein 69) | Using a linear mixed model, differential expression with age was identified in C7orf63 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CFD (complement factor D (adipsin)) | Comparison of DNA methylation showed a significantly decreased methylation level of CFD in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -21.7 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CFD (complement factor D (adipsin)) | Comparison of DNA methylation showed a significantly increased methylation level of CFD in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 22.2 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CFH (complement factor H) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 166.79 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CFH (complement factor H) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 138.86 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CFH (complement factor H) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 210.85 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CFHR1 (complement factor H-related 1) | Male and Female | 26 | 106 | Brain | 42.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CFHR1 (complement factor H-related 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 88.04 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CFHR1 (complement factor H-related 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 126.47 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CFHR1 (complement factor H-related 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 144.16 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CGGBP1 (CGG triplet repeat binding protein 1) | Using a linear mixed model, differential expression with age was identified in CGGBP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10) | Using a linear mixed model, differential expression with age was identified in CHCHD10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CHCHD5 (coiled-coil-helix-coiled-coil-helix domain containing 5) | Using a linear mixed model, differential expression with age was identified in CHCHD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cherp (calcium homeostasis endoplasmic reticulum protein) | Male and Female | 6 | 22 | Liver | -7.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CHI3L2 (chitinase 3-like 2) | Using a linear mixed model, differential expression with age was identified in CHI3L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Chi3l3 (chitinase 3-like 3) | Male and Female | 3 | 23 | Hematological System | -53.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CHMP2A (chromatin modifying protein 2A) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CHN1 (chimerin (chimaerin) 1) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CHN1 (chimerin (chimaerin) 1) | Using a linear mixed model, differential expression with age was identified in CHN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CHN2 (chimerin 2) | Using a linear mixed model, differential expression with age was identified in CHN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Chordc1 (cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CHPF (chondroitin polymerizing factor) | Using a linear mixed model, differential expression with age was identified in CHPF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Chrnb1 (cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)) | Male and Female | 8 | 24 | Muscle | 6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CHRNE (cholinergic receptor, nicotinic, epsilon (muscle)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CHRNE and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CHST13 (carbohydrate (chondroitin 4) sulfotransferase 13) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CHST13 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Chst2 (carbohydrate sulfotransferase 2) | Male and Female | 2 | 26 | Lung | -10.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CHST7 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7) | Using a linear mixed model, differential expression with age was identified in CHST7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Chsy1 (chondroitin sulfate synthase 1) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CHSY3 (chondroitin sulfate synthase 3) | Using a linear mixed model, differential expression with age was identified in CHSY3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CIAO1 (cytosolic iron-sulfur assembly component 1) | Using a linear mixed model, differential expression with age was identified in CIAO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CIART (circadian associated repressor of transcription) | Using a linear mixed model, differential expression with age was identified in C1orf51 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CIDEA (cell death-inducing DFFA-like effector a) | Using a linear mixed model, differential expression with age was identified in CIDEA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cideb (cell death-inducing DNA fragmentation factor, alpha subunit-like effector B) | Male and Female | 6 | 22 | Liver | -5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CIRBP (cold inducible RNA binding protein) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CISH (cytokine inducible SH2-containing protein) | Using a linear mixed model, differential expression with age was identified in CISH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CISH (cytokine inducible SH2-containing protein) | Using a linear mixed model, differential expression with age was identified in CISH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ckap2 (cytoskeleton associated protein 2) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CKB (creatine kinase, brain) | Male and Female | 27 | 92 | Kidney | -10.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| CKB (creatine kinase, brain) | Using a linear mixed model, differential expression with age was identified in CKB in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CKLF (chemokine-like factor) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CKMT2 (creatine kinase, mitochondrial 2 (sarcomeric)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CLCF1 (cardiotrophin-like cytokine factor 1) | Using a linear mixed model, differential expression with age was identified in CLCF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Clcn3 (chloride channel 3) | Male and Female | 2 | 26 | Lung | 3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CLCN6 (chloride channel, voltage-sensitive 6) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CLCN6 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CLDN5 (claudin 5) | Using a linear mixed model, differential expression with age was identified in CLDN5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLDN8 (claudin 8) | Male and Female | 27 | 92 | Kidney | -17.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| CLEC10A (C-type lectin domain family 10, member A) | Using a linear mixed model, differential expression with age was identified in CLEC10A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLEC10A (C-type lectin domain family 10, member A) | Using a linear mixed model, differential expression with age was identified in CLEC10A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Clec11a (C-type lectin domain family 11, member a) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Clec1b (C-type lectin domain family 1, member b) | Male and Female | 2 | 26 | Lung | 22.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CLEC3B (C-type lectin domain family 3, member B) | Comparison of DNA methylation showed a significantly decreased methylation level of CLEC3B in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -18.0 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Clic4 (chloride intracellular channel 4 (mitochondrial)) | Male and Female | 5 | 30 | Anatomical System | 4.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Clic4 (chloride intracellular channel 4 (mitochondrial)) | Male and Female | 6 | 22 | Liver | 3.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Clint1 (clathrin interactor 1) | Male and Female | 8 | 24 | Muscle | 5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CLK2 (CDC-like kinase 2) | Using a linear mixed model, differential expression with age was identified in CLK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLK4 (CDC-like kinase 4) | Using a linear mixed model, differential expression with age was identified in CLK4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLMP (CXADR-like membrane protein) | Using a linear mixed model, differential expression with age was identified in CLMP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLPSL2 (colipase-like 2) | Using a linear mixed model, differential expression with age was identified in CLPSL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLSTN1 (calsyntenin 1) | Using a linear mixed model, differential expression with age was identified in CLSTN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLSTN3 (calsyntenin 3) | Using a linear mixed model, differential expression with age was identified in CLSTN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLTA (clathrin, light chain A) | Using a linear mixed model, differential expression with age was identified in CLTA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 25.86 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 33.08 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 41.7 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 58.9 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 22.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 23.49 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 47.94 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 25.47 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 30.95 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLU (clusterin) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 56.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CLYBL (citrate lyase beta like) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CMSS1 (cms1 ribosomal small subunit homolog (yeast)) | Using a linear mixed model, differential expression with age was identified in CMSS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) | Using a linear mixed model, differential expression with age was identified in CMTM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cmtm8 (CKLF-like MARVEL transmembrane domain containing 8) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CNDP2 (CNDP dipeptidase 2 (metallopeptidase M20 family)) | Using a linear mixed model, differential expression with age was identified in CNDP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CNKSR3 (CNKSR family member 3) | Using a linear mixed model, differential expression with age was identified in CNKSR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CNN1 (calponin 1, basic, smooth muscle) | Using a linear mixed model, differential expression with age was identified in CNN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cnot8 (CCR4-NOT transcription complex, subunit 8) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Cnpy4 (canopy 4 homolog (zebrafish)) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COA3 (cytochrome c oxidase assembly factor 3) | Using a linear mixed model, differential expression with age was identified in COA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COA5 (cytochrome c oxidase assembly factor 5) | Using a linear mixed model, differential expression with age was identified in COA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cog5 (component of oligomeric golgi complex 5) | Male and Female | 6 | 22 | Liver | 52.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| COL11A1 (collagen, type XI, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL11A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL14A1 (collagen, type XIV, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL14A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Col16a1 (collagen, type XVI, alpha 1) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COL16A1 (collagen, type XVI, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL16A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL17A1 (collagen, type XVII, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL17A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL1A1 (collagen, type I, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL1A1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL1A1 (collagen, type I, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL1A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Col1a2 (collagen, type I, alpha 2) | Male and Female | 2 | 26 | Lung | -11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COL1A2 (collagen, type I, alpha 2) | Using a linear mixed model, differential expression with age was identified in COL1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL1A2 (collagen, type I, alpha 2) | Using a linear mixed model, differential expression with age was identified in COL1A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Col27a1 (collagen, type XXVII, alpha 1) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Col3a1 (collagen, type III, alpha 1) | Male and Female | 2 | 26 | Lung | -11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COL3A1 (collagen, type III, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL3A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL4A2 (collagen, type IV, alpha 2) | Using a linear mixed model, differential expression with age was identified in COL4A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL4A5 (collagen, type IV, alpha 5) | Using a linear mixed model, differential expression with age was identified in COL4A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL4A6 (collagen, type IV, alpha 6) | Using a linear mixed model, differential expression with age was identified in COL4A6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL5A1 (collagen, type V, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL5A1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL5A2 (collagen, type V, alpha 2) | Using a linear mixed model, differential expression with age was identified in COL5A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Col6a3 (collagen, type VI, alpha 3) | Male and Female | 2 | 26 | Lung | -9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COL7A1 (collagen, type VII, alpha 1) | Using a linear mixed model, differential expression with age was identified in COL7A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COL8A2 (collagen, type VIII, alpha 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of COL8A2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| COLQ (collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase) | Using a linear mixed model, differential expression with age was identified in COLQ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COMMD1 (copper metabolism (Murr1) domain containing 1) | Using a linear mixed model, differential expression with age was identified in COMMD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Commd4 (COMM domain containing 4) | Male and Female | 2 | 15 | Hippocampus | -1.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| COMMD7 (COMM domain containing 7) | Using a linear mixed model, differential expression with age was identified in COMMD7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COMT (catechol-O-methyltransferase) | Using a linear mixed model, differential expression with age was identified in COMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COPG1 (coatomer protein complex, subunit gamma 1) | Using a linear mixed model, differential expression with age was identified in COPG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cops5 (COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| COPS7B (COP9 signalosome subunit 7B) | Using a linear mixed model, differential expression with age was identified in COPS7B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Coq5 (coenzyme Q5 homolog, methyltransferase (yeast)) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Coq7 (demethyl-Q 7) | Male and Female | 6 | 22 | Liver | 10.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| COQ9 (coenzyme Q9 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CORIN (corin, serine peptidase) | Using a linear mixed model, differential expression with age was identified in CORIN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CORO1B (coronin, actin binding protein, 1B) | Using a linear mixed model, differential expression with age was identified in CORO1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CORO6 (coronin 6) | Using a linear mixed model, differential expression with age was identified in CORO6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| COX4I1 (cytochrome c oxidase subunit IV isoform 1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Cox6a1 (cytochrome c oxidase, subunit VI a, polypeptide 1) | Male and Female | 2 | 26 | Lung | 1.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| COX7B (cytochrome c oxidase subunit VIIb) | Male and Female | 22 | 73 | Skeletal Muscle | -4.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| Cox8b (cytochrome c oxidase, subunit VIIIb) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Cpeb1 (cytoplasmic polyadenylation element binding protein 1) | Male and Female | 6 | 22 | Liver | -53.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CPN2 (carboxypeptidase N, polypeptide 2) | Using a linear mixed model, differential expression with age was identified in CPN2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CPNE1 (copine I) | Using a linear mixed model, differential expression with age was identified in CPNE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cpne2 (copine II) | Male and Female | 8 | 24 | Muscle | 42.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CPS1 (carbamoyl-phosphate synthetase 1, mitochondrial) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CPT2 (carnitine palmitoyltransferase 2) | Using a linear mixed model, differential expression with age was identified in CPT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CPXM1 (carboxypeptidase X (M14 family), member 1) | Using a linear mixed model, differential expression with age was identified in CPXM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CPZ (carboxypeptidase Z) | Using a linear mixed model, differential expression with age was identified in CPZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CRAT (carnitine O-acetyltransferase) | Using a linear mixed model, differential expression with age was identified in CRAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Creg1 (cellular repressor of E1A-stimulated genes 1) | Male and Female | 2 | 26 | Lung | 3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CREG1 (cellular repressor of E1A-stimulated genes 1) | Using a linear mixed model, differential expression with age was identified in CREG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like)) | Male and Female | 22 | 73 | Skeletal Muscle | 9.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like)) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Crlf3 (cytokine receptor-like factor 3) | Male and Female | 5 | 30 | Anatomical System | 3.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| CRMP1 (collapsin response mediator protein 1) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CRNN (cornulin) | Using a linear mixed model, differential expression with age was identified in CRNN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CROT (carnitine O-octanoyltransferase) | Using a linear mixed model, differential expression with age was identified in CROT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CRP (C-reactive protein, pentraxin-related) | Blood C-reactive protein (CRP) level was significant higher in thirty-seven elderly subjects (median age, 87, range 70-95 years; minimum: 0.04 mg\\dL, median: 0.41 mg\\dL, maximum: 51.62 mg\\dL) than in 22 young subjects (median age, 26, range 21-37 years; minimum: 0.08 mg\\dL, median: 0.21 mg\\dL, maximum: 0.70 mg\\dL). | Male and Female | 26 | 87 | Plasma | 2871: Ogawa et al. (2008) "The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly." Immun Ageing 5:13 (18950479) | ||
| CRTAP (cartilage associated protein) | Using a linear mixed model, differential expression with age was identified in CRTAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cryba1 (crystallin, beta A1) | Male and Female | 3 | 23 | Hematological System | 95.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CRYBB3 (crystallin, beta B3) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CRYM (crystallin, mu) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Cs (citrate synthase) | Male and Female | 5 | 25 | Skeletal Muscle | 4.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| CSAD (cysteine sulfinic acid decarboxylase) | Using a linear mixed model, differential expression with age was identified in CSAD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CSF2 (colony stimulating factor 2 (granulocyte-macrophage)) | Male and Female | 26 | 106 | Brain | 6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CSN3 (casein kappa) | Comparison of DNA methylation showed a significantly decreased methylation level of CSN3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.0 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CSN3 (casein kappa) | Comparison of DNA methylation showed a significantly increased methylation level of CSN3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 16.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| CSNK1D (casein kinase 1, delta) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CSNK1D and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| CSPP1 (centrosome and spindle pole associated protein 1) | Using a linear mixed model, differential expression with age was identified in CSPP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Csprs (component of Sp100-rs) | Male and Female | 2 | 26 | Lung | 27.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Csprs (component of Sp100-rs) | Male and Female | 3 | 23 | Hematological System | 68.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Csrp1 (cysteine and glycine-rich protein 1) | Male and Female | 5 | 25 | Skeletal Muscle | 14.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| CST3 (cystatin C) | Using a linear mixed model, differential expression with age was identified in CST3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CST6 (cystatin E/M) | Using a linear mixed model, differential expression with age was identified in CST6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CSTB (cystatin B (stefin B)) | Using a linear mixed model, differential expression with age was identified in CSTB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa) | Using a linear mixed model, differential expression with age was identified in CSTF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CTAGE4 (CTAGE family, member 4) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ctf1 (cardiotrophin 1) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| CTHRC1 (collagen triple helix repeat containing 1) | Using a linear mixed model, differential expression with age was identified in CTHRC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ctla2a (cytotoxic T lymphocyte-associated protein 2 alpha) | Male and Female | 2 | 15 | Hippocampus | 13.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| CTNNAL1 (catenin (cadherin-associated protein), alpha-like 1) | Using a linear mixed model, differential expression with age was identified in CTNNAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CTSA (cathepsin A) | Using a linear mixed model, differential expression with age was identified in CTSA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CTSC (cathepsin C) | Using a linear mixed model, differential expression with age was identified in CTSC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ctse (cathepsin E) | Male and Female | 5 | 30 | Anatomical System | -8.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| CTSF (cathepsin F) | Using a linear mixed model, differential expression with age was identified in CTSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CTSG (cathepsin G) | Using a linear mixed model, differential expression with age was identified in CTSG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ctsk (cathepsin K) | Male and Female | 2 | 24 | Visual Apparatus | 58.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| CTSK (cathepsin K) | Using a linear mixed model, differential expression with age was identified in CTSK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ctss (cathepsin S) | Male and Female | 2 | 24 | Visual Apparatus | 74.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| Ctss (cathepsin S) | Male and Female | 5 | 30 | Anatomical System | 6.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Ctss (cathepsin S) | Male and Female | 3 | 23 | Hematological System | -21.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Ctss (cathepsin S) | Male and Female | 2 | 15 | Hippocampus | 4.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| CTSV (cathepsin V) | Using a linear mixed model, differential expression with age was identified in CTSV in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ctsz (cathepsin Z) | Male and Female | 5 | 30 | Anatomical System | 11.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Ctsz (cathepsin Z) | Male and Female | 2 | 15 | Hippocampus | 6.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| CTSZ (cathepsin Z) | Using a linear mixed model, differential expression with age was identified in CTSZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CTSZ (cathepsin Z) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CTSZ and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Cttnbp2nl (CTTNBP2 N-terminal like) | Male and Female | 3 | 23 | Hematological System | 12.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CUL9 (cullin 9) | Using a linear mixed model, differential expression with age was identified in CUL9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cuta (cutA divalent cation tolerance homolog (E. coli)) | Male and Female | 2 | 15 | Hippocampus | -2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| CUX2 (cut-like homeobox 2) | Male and Female | 26 | 106 | Brain | -19.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Cx3cl1 (chemokine (C-X3-C motif) ligand 1) | Male and Female | 5 | 25 | Skeletal Muscle | 10.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Cx3cl1 (chemokine (C-X3-C motif) ligand 1) | Male and Female | 5 | 30 | Anatomical System | -2.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of temporal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | -46.68 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of hippocampus CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | -31.6 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -61.04 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -56.19 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -61.1 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -58.02 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CX3CL1 (chemokine (C-X3-C motif) ligand 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CX3CL1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Cxcl1 (chemokine (C-X-C motif) ligand 1) | Male and Female | 5 | 30 | Anatomical System | 33.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| CXCL12 (chemokine (C-X-C motif) ligand 12) | Gene expression showed a significant (p<0.01) decrease in the expression of hippocampus CXCL12 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | -30.87 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| Cxcl13 (chemokine (C-X-C motif) ligand 13) | Male and Female | 2 | 26 | Lung | 20.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Cxcl14 (chemokine (C-X-C motif) ligand 14) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CXCL14 (chemokine (C-X-C motif) ligand 14) | Using a linear mixed model, differential expression with age was identified in CXCL14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CXCL16 (chemokine (C-X-C motif) ligand 16) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 100.64 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CXCL16 (chemokine (C-X-C motif) ligand 16) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 78.92 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CXCL16 (chemokine (C-X-C motif) ligand 16) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 44.13 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| CXCL5 (chemokine (C-X-C motif) ligand 5) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CXCL5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 64.89 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| Cxcr3 (chemokine (C-X-C motif) receptor 3) | Male and Female | 2 | 26 | Lung | 20.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| CXorf40B (chromosome X open reading frame 40B) | Using a linear mixed model, differential expression with age was identified in CXorf40B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CXorf57 (chromosome X open reading frame 57) | Male and Female | 20 | 75 | Skeletal Muscle | 35.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CXorf57 (chromosome X open reading frame 57) | Using a linear mixed model, differential expression with age was identified in CXorf57 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CXXC1 (CXXC finger protein 1) | Using a linear mixed model, differential expression with age was identified in CXXC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB561A3 (cytochrome b561 family, member A3) | Using a linear mixed model, differential expression with age was identified in CYB561A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB561D2 (cytochrome b561 family, member D2) | Using a linear mixed model, differential expression with age was identified in CYB561D2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYB5A (cytochrome b5 type A (microsomal)) | Using a linear mixed model, differential expression with age was identified in CYB5A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYC1 (cytochrome c-1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYC1 (cytochrome c-1) | Using a linear mixed model, differential expression with age was identified in CYC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYCS (cytochrome c, somatic) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYFIP2 (cytoplasmic FMR1 interacting protein 2) | mRNA editing of CYFIP2, a p53 inducible protein thought to be involved in synaptic maintenance, decreases with age. No changes with age in mRNA editing were observed for GABRA3. | Male and Female | -1 | -1 | Frontal Lobe | 0.0 | 2900: Nicholas et al. (2010) "Age-related gene-specific changes of A-to-I mRNA editing in the human brain." Mech. Ageing Dev. 131(6):445-447 (20538013) | |
| CYFIP2 (cytoplasmic FMR1 interacting protein 2) | Male and Female | 27 | 92 | Kidney | -11.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| CYGB (cytoglobin) | Using a linear mixed model, differential expression with age was identified in CYGB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) | Using a linear mixed model, differential expression with age was identified in CYP1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP1B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP27A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cyp2c39 (cytochrome P450, family 2, subfamily c, polypeptide 39) | Male and Female | 6 | 22 | Liver | -8.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| CYP2J2 (cytochrome P450, family 2, subfamily J, polypeptide 2) | Male and Female | 26 | 106 | Brain | 9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) | Using a linear mixed model, differential expression with age was identified in CYP3A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4F12 (cytochrome P450, family 4, subfamily F, polypeptide 12) | Using a linear mixed model, differential expression with age was identified in CYP4F12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) | Using a linear mixed model, differential expression with age was identified in CYP4F22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Male and Female | 20 | 75 | Skeletal Muscle | 12.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP4X1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) | Using a linear mixed model, differential expression with age was identified in CYP4X1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1) | Male and Female | 3 | 23 | Hematological System | 35.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Cysltr2 (cysteinyl leukotriene receptor 2) | Male and Female | 3 | 23 | Hematological System | 17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| CYTL1 (cytokine-like 1) | Using a linear mixed model, differential expression with age was identified in CYTL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| D030056L22Rik (RIKEN cDNA D030056L22 gene) | Male and Female | 5 | 25 | Skeletal Muscle | -7.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| D0H4S114 (DNA segment, human D4S114) | Male and Female | 2 | 26 | Lung | -12.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| D0H4S114 (DNA segment, human D4S114) | Male and Female | 2 | 15 | Hippocampus | -5.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| D10627 (cDNA sequence D10627) | Male and Female | 5 | 25 | Skeletal Muscle | -8.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| D1Ertd705e (DNA segment, Chr 1, ERATO Doi 705, expressed) | Male and Female | 3 | 23 | Hematological System | 61.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| D4Bwg0951e (DNA segment, Chr 4, Brigham & Women's Genetics 0951 expressed) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| D630004K10Rik (RIKEN cDNA D630004K10 gene) | Male and Female | 3 | 23 | Hematological System | -16.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| DAAM2 (dishevelled associated activator of morphogenesis 2) | Male and Female | 22 | 73 | Skeletal Muscle | -8.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| DAAM2 (dishevelled associated activator of morphogenesis 2) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DAB2 (Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in DAB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DACT2 (dishevelled-binding antagonist of beta-catenin 2) | Using a linear mixed model, differential expression with age was identified in DACT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DAD1 (defender against cell death 1) | Using a linear mixed model, differential expression with age was identified in DAD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DAP (death-associated protein) | Using a linear mixed model, differential expression with age was identified in DAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dap3 (death associated protein 3) | Male and Female | 5 | 25 | Skeletal Muscle | -3.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| DBN1 (drebrin 1) | Using a linear mixed model, differential expression with age was identified in DBN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DBNDD1 (dysbindin (dystrobrevin binding protein 1) domain containing 1) | Using a linear mixed model, differential expression with age was identified in DBNDD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DBNL (drebrin-like) | Using a linear mixed model, differential expression with age was identified in DBNL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCAF15 (DDB1 and CUL4 associated factor 15) | Using a linear mixed model, differential expression with age was identified in DCAF15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCBLD2 (discoidin, CUB and LCCL domain containing 2) | Using a linear mixed model, differential expression with age was identified in DCBLD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCLK1 (doublecortin-like kinase 1) | Using a linear mixed model, differential expression with age was identified in DCLK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCP2 (decapping mRNA 2) | Using a linear mixed model, differential expression with age was identified in DCP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCST1 (DC-STAMP domain containing 1) | Using a linear mixed model, differential expression with age was identified in DCST1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCTN1 (dynactin 1 (p150, glued homolog, Drosophila)) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DCTN2 (dynactin 2 (p50)) | Using a linear mixed model, differential expression with age was identified in DCTN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dctn2 (dynactin 2) | Male and Female | 5 | 25 | Skeletal Muscle | 9.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Dctpp1 (dCTP pyrophosphatase 1) | Male and Female | 5 | 30 | Anatomical System | -7.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| DCTPP1 (dCTP pyrophosphatase 1) | Using a linear mixed model, differential expression with age was identified in DCTPP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DCXR (dicarbonyl/L-xylulose reductase) | Using a linear mixed model, differential expression with age was identified in DCXR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ddah2 (dimethylarginine dimethylaminohydrolase 2) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Ddah2 (dimethylarginine dimethylaminohydrolase 2) | Male and Female | 2 | 15 | Hippocampus | -3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| DDB2 (damage-specific DNA binding protein 2, 48kDa) | Using a linear mixed model, differential expression with age was identified in DDB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ddi2 (DNA-damage inducible protein 2) | Male and Female | 5 | 22 | Brain | -3.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| DDN (dendrin) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DDR1 (discoidin domain receptor tyrosine kinase 1) | Male and Female | 26 | 106 | Brain | 9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DDRGK1 (DDRGK domain containing 1) | Using a linear mixed model, differential expression with age was identified in DDRGK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DDT (D-dopachrome tautomerase) | Male and Female | 22 | 73 | Skeletal Muscle | -3.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| DDX19B (DEAD (Asp-Glu-Ala-As) box polypeptide 19B) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DDX24 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 24) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DDX26B (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B) | Using a linear mixed model, differential expression with age was identified in DDX26B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DDX27 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 27) | Using a linear mixed model, differential expression with age was identified in DDX27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DDX39 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39) | Male and Female | 26 | 106 | Brain | 8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DDX39B (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B) | Using a linear mixed model, differential expression with age was identified in DDX39B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ddx3y (DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked) | Male and Female | 8 | 24 | Muscle | 8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| DDX42 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 42) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DDX55 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 55) | Using a linear mixed model, differential expression with age was identified in DDX55 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DDX59 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 59) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DDX59 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 59) | Using a linear mixed model, differential expression with age was identified in DDX59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DEFB1 (defensin, beta 1) | Male and Female | 27 | 92 | Kidney | -8.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| DEGS2 (delta(4)-desaturase, sphingolipid 2) | Using a linear mixed model, differential expression with age was identified in DEGS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DES (desmin) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of DES and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| DESI1 (desumoylating isopeptidase 1) | Using a linear mixed model, differential expression with age was identified in DESI1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| destrin-2 pseudogene | Male and Female | 26 | 106 | Brain | -15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DFNA5 (deafness, autosomal dominant 5) | Using a linear mixed model, differential expression with age was identified in DFNA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DFNB59 (deafness, autosomal recessive 59) | Using a linear mixed model, differential expression with age was identified in DFNB59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DGAT2 (diacylglycerol O-acyltransferase 2) | Using a linear mixed model, differential expression with age was identified in DGAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DGKB (diacylglycerol kinase, beta 90kDa) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DHCR24 (24-dehydrocholesterol reductase) | Using a linear mixed model, differential expression with age was identified in DHCR24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dhcr7 (7-dehydrocholesterol reductase) | Male and Female | 6 | 22 | Liver | 19.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| DHCR7 (7-dehydrocholesterol reductase) | Using a linear mixed model, differential expression with age was identified in DHCR7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DHRS11 (dehydrogenase/reductase (SDR family) member 11) | Using a linear mixed model, differential expression with age was identified in DHRS11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DHRS11 (dehydrogenase/reductase (SDR family) member 11) | Using a linear mixed model, differential expression with age was identified in DHRS11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DHRS3 (dehydrogenase/reductase (SDR family) member 3) | Comparison of DNA methylation showed a significantly decreased methylation level of DHRS3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.8 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| DHRS3 (dehydrogenase/reductase (SDR family) member 3) | Comparison of DNA methylation showed a significantly decreased methylation level of DHRS3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -18.6 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| DHRS7B (dehydrogenase/reductase (SDR family) member 7B) | Using a linear mixed model, differential expression with age was identified in DHRS7B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DHRS9 (dehydrogenase/reductase (SDR family) member 9) | Using a linear mixed model, differential expression with age was identified in DHRS9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DHX15 (DEAH (Asp-Glu-Ala-His) box helicase 15) | Using a linear mixed model, differential expression with age was identified in DHX15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dhx40 (DEAH (Asp-Glu-Ala-His) box polypeptide 40) | Male and Female | 3 | 23 | Hematological System | 12.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| DIDO1 (death inducer-obliterator 1) | Using a linear mixed model, differential expression with age was identified in DIDO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dip2b (DIP2 disco-interacting protein 2 homolog B (Drosophila)) | Male and Female | 5 | 25 | Skeletal Muscle | -1.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| DIRAS3 (DIRAS family, GTP-binding RAS-like 3) | Using a linear mixed model, differential expression with age was identified in DIRAS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DKK1 (dickkopf 1 homolog (Xenopus laevis)) | Comparison of DNA methylation showed a significantly increased methylation level of DKK1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 16.2 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| DKK1 (dickkopf 1 homolog (Xenopus laevis)) | Using a linear mixed model, differential expression with age was identified in DKK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DKKL1 (dickkopf-like 1) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DKKL1 (dickkopf-like 1) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DKKL1 (dickkopf-like 1) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DKKL1 (dickkopf-like 1) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DLAT (dihydrolipoamide S-acetyltransferase) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DLC1 (DLC1 Rho GTPase activating protein) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of DLC1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| DLEC1 (deleted in lung and esophageal cancer 1) | Using a linear mixed model, differential expression with age was identified in DLEC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DLG5 (discs, large homolog 5 (Drosophila)) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DLGAP1 (discs, large (Drosophila) homolog-associated protein 1) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DLK2 (delta-like 2 homolog (Drosophila)) | Using a linear mixed model, differential expression with age was identified in DLK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DLL1 (delta-like 1 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in DLL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DLX5 (distal-less homeobox 5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of DLX5 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Dmbt1 (deleted in malignant brain tumors 1) | Male and Female | 4 | 15 | Cochlea | 1.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| DMBX1 (diencephalon/mesencephalon homeobox 1) | Using a linear mixed model, differential expression with age was identified in DMBX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DMD (dystrophin) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DMD (dystrophin) | Using a linear mixed model, differential expression with age was identified in DMD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DMRT2 (doublesex and mab-3 related transcription factor 2) | Male and Female | 20 | 75 | Skeletal Muscle | -12.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Dmrtc1a (DMRT-like family C1a) | Male and Female | 3 | 23 | Hematological System | 13.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| DMTF1 (cyclin D binding myb-like transcription factor 1) | Using a linear mixed model, differential expression with age was identified in DMTF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DNAH17 (dynein, axonemal, heavy chain 17) | Using a linear mixed model, differential expression with age was identified in DNAH17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DNAH8 (dynein, axonemal, heavy chain 8) | Using a linear mixed model, differential expression with age was identified in DNAH8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dnaja1 (DnaJ (Hsp40) homolog, subfamily A, member 1) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| DNAJA1 (DnaJ (Hsp40) homolog, subfamily A, member 1) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Dnajb1 (DnaJ (Hsp40) homolog, subfamily B, member 1) | Male and Female | 2 | 26 | Lung | -10.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| DNAJC1 (DnaJ (Hsp40) homolog, subfamily C, member 1) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DNAJC15 (DnaJ (Hsp40) homolog, subfamily C, member 15) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DNASE1L2 (deoxyribonuclease I-like 2) | Using a linear mixed model, differential expression with age was identified in DNASE1L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DNM1L (dynamin 1-like) | Male and Female | 26 | 106 | Brain | -14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DNM2 (dynamin 2) | Using a linear mixed model, differential expression with age was identified in DNM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dnm3 (dynamin 3) | Male and Female | 3 | 23 | Hematological System | 18.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Dnmt3a (DNA methyltransferase 3A) | Dnmt3a mRNA content in heart of mice decrease from age 2 to 22 month. | Male | 2 | 22 | Heart | 2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386) | ||
| DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) | Using a linear mixed model, differential expression with age was identified in DNMT3B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DOCK11 (dedicator of cytokinesis 11) | Male and Female | 27 | 92 | Kidney | 24.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| DOCK2 (dedicator of cytokinesis 2) | Using a linear mixed model, differential expression with age was identified in DOCK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DOCK3 (dedicator of cytokinesis 3) | Using a linear mixed model, differential expression with age was identified in DOCK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dok1 (docking protein 1) | Male and Female | 5 | 25 | Skeletal Muscle | -12.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| DOLK (dolichol kinase) | Using a linear mixed model, differential expression with age was identified in DOLK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DONSON (downstream neighbor of SON) | Using a linear mixed model, differential expression with age was identified in DONSON in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DOPEY1 (dopey family member 1) | Male and Female | 22 | 73 | Skeletal Muscle | 9.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| DPCD (deleted in primary ciliary dyskinesia homolog (mouse)) | Using a linear mixed model, differential expression with age was identified in DPCD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DPH5 (DPH5 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DPM3 (dolichyl-phosphate mannosyltransferase polypeptide 3) | Using a linear mixed model, differential expression with age was identified in DPM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DPP8 (dipeptidyl-peptidase 8) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DPP8 (dipeptidyl-peptidase 8) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DPP8 (dipeptidyl-peptidase 8) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DPP8 (dipeptidyl-peptidase 8) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| DPT (dermatopontin) | Using a linear mixed model, differential expression with age was identified in DPT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DPYSL3 (dihydropyrimidinase-like 3) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Dram1 (DNA-damage regulated autophagy modulator 1) | Male and Female | 3 | 23 | Hematological System | -12.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Dram2 (VDNA-damage regulated autophagy modulator 2) | Male and Female | 5 | 25 | Skeletal Muscle | 16.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| DST (dystonin) | Using a linear mixed model, differential expression with age was identified in DST in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DUOXA1 (dual oxidase maturation factor 1) | Using a linear mixed model, differential expression with age was identified in DUOXA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DUS1L (dihydrouridine synthase 1-like (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in DUS1L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DUSP13 (dual specificity phosphatase 13) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DUSP16 (dual specificity phosphatase 16) | Using a linear mixed model, differential expression with age was identified in DUSP16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dusp22 (dual specificity phosphatase 22) | Male and Female | 3 | 23 | Hematological System | -18.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| DUSP3 (dual specificity phosphatase 3) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| DUSP3 (dual specificity phosphatase 3) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| DUSP5 (dual specificity phosphatase 5) | Using a linear mixed model, differential expression with age was identified in DUSP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Dusp6 (dual specificity phosphatase 6) | Male and Female | 2 | 15 | Hippocampus | -3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Dut (deoxyuridine triphosphatase) | Male and Female | 5 | 30 | Anatomical System | -25.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| DUT (deoxyuridine triphosphatase) | Using a linear mixed model, differential expression with age was identified in DUT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DVL3 (dishevelled segment polarity protein 3) | Using a linear mixed model, differential expression with age was identified in DVL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| DYSF (dysferlin) | Using a linear mixed model, differential expression with age was identified in DYSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| E2F2 (E2F transcription factor 2) | Using a linear mixed model, differential expression with age was identified in E2F2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ear5 (eosinophil-associated, ribonuclease A family, member 5) | Male and Female | 5 | 22 | Brain | 3385.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| EBI3 (Epstein-Barr virus induced 3) | Using a linear mixed model, differential expression with age was identified in EBI3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ebi3 (Epstein-Barr virus induced gene 3) | Male and Female | 3 | 23 | Hematological System | -27.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| EBP (emopamil binding protein (sterol isomerase)) | Using a linear mixed model, differential expression with age was identified in EBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ECEL1 (endothelin converting enzyme-like 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ECEL1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ECM1 (extracellular matrix protein 1) | Using a linear mixed model, differential expression with age was identified in ECM1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ECM2 (extracellular matrix protein 2, Female organ and adipocyte specific) | Male and Female | 26 | 106 | Brain | 13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ECSIT (ECSIT homolog (Drosophila)) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EDARADD (EDAR-associated death domain) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of EDARADD and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| EDNRB (endothelin receptor type B) | Using a linear mixed model, differential expression with age was identified in EDNRB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EDRF1 (erythroid differentiation regulatory factor 1) | Using a linear mixed model, differential expression with age was identified in EDRF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EEF1A2 (eukaryotic translation elongation factor 1 alpha 2) | Using a linear mixed model, differential expression with age was identified in EEF1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EEF2K (eukaryotic elongation factor-2 kinase) | Using a linear mixed model, differential expression with age was identified in EEF2K in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EFCAB1 (EF-hand calcium binding domain 1) | Using a linear mixed model, differential expression with age was identified in EFCAB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EFCAB7 (EF-hand calcium binding domain 7) | Male and Female | 20 | 75 | Skeletal Muscle | 12.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) | Male and Female | 26 | 106 | Brain | 34.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) | Using a linear mixed model, differential expression with age was identified in EFEMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EFEMP2 (EGF-containing fibulin-like extracellular matrix protein 2) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EFEMP2 (EGF-containing fibulin-like extracellular matrix protein 2) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| EFHC1 (EF-hand domain (C-terminal) containing 1) | Using a linear mixed model, differential expression with age was identified in EFHC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EFHD1 (EF-hand domain family, member D1) | Male and Female | 27 | 92 | Kidney | -9.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| EFNA1 (ephrin-A1) | Using a linear mixed model, differential expression with age was identified in EFNA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EGF (epidermal growth factor (beta-urogastrone)) | Male and Female | 27 | 92 | Kidney | -25.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| EGFR (epidermal growth factor receptor) | Using a linear mixed model, differential expression with age was identified in EGFR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EHD1 (EH-domain containing 1) | Male and Female | 26 | 106 | Brain | 4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Ehd3 (EH-domain containing 3) | Male and Female | 3 | 23 | Hematological System | 33.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| EHD4 (EH-domain containing 4) | Using a linear mixed model, differential expression with age was identified in EHD4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EI24 (etoposide induced 2.4) | Using a linear mixed model, differential expression with age was identified in EI24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) | Male and Female | 5 | 25 | Skeletal Muscle | -3.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2) | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Eif4a2 (eukaryotic translation initiation factor 4A2) | Male and Female | 5 | 25 | Skeletal Muscle | 5.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| EIF4E2 (eukaryotic translation initiation factor 4E family member 2) | Using a linear mixed model, differential expression with age was identified in EIF4E2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EIF4H (eukaryotic translation initiation factor 4H) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ELAVL1 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)) | Male and Female | 26 | 106 | Brain | -69.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ELAVL2 (ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Ell2 (elongation factor RNA polymerase II 2) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ELMO1 (engulfment and cell motility 1) | Using a linear mixed model, differential expression with age was identified in ELMO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELOVL1 (ELOVL fatty acid elongase 1) | Using a linear mixed model, differential expression with age was identified in ELOVL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELOVL3 (ELOVL fatty acid elongase 3) | Using a linear mixed model, differential expression with age was identified in ELOVL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELOVL4 (ELOVL fatty acid elongase 4) | Using a linear mixed model, differential expression with age was identified in ELOVL4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELOVL5 (ELOVL fatty acid elongase 5) | Using a linear mixed model, differential expression with age was identified in ELOVL5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELOVL6 (ELOVL fatty acid elongase 6) | Using a linear mixed model, differential expression with age was identified in ELOVL6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ELP3 (elongator acetyltransferase complex subunit 3) | Gene expression showed a significant (p<E-3) decrease in the expression of ELP3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -54.13 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| EMCN (endomucin) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EMILIN2 (elastin microfibril interfacer 2) | Using a linear mixed model, differential expression with age was identified in EMILIN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EMILIN3 (elastin microfibril interfacer 3) | Using a linear mixed model, differential expression with age was identified in EMILIN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EML1 (echinoderm microtubule associated protein like 1) | Gene expression showed a significant (p<E-3) decrease in the expression of EML1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -87.79 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| EML1 (echinoderm microtubule associated protein like 1) | Using a linear mixed model, differential expression with age was identified in EML1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EML4 (echinoderm microtubule associated protein like 4) | Using a linear mixed model, differential expression with age was identified in EML4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EMP3 (epithelial membrane protein 3) | Using a linear mixed model, differential expression with age was identified in EMP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EMX1 (empty spiracles homeobox 1) | Gene expression showed a significant (p<E-3) increase in the expression of EMX1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 80.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| En1 (engrailed 1) | Male and Female | 8 | 24 | Muscle | 8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| EN1 (engrailed homeobox 1) | Comparison of DNA methylation showed a significantly increased methylation level of EN1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 18.8 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ENC1 (ectodermal-neural cortex (with BTB-like domain)) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ENO2 (enolase 2 (gamma, neuronal)) | Using a linear mixed model, differential expression with age was identified in ENO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ENO3 (enolase 3 (beta, muscle)) | Male and Female | 26 | 106 | Brain | -38.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ENOSF1 (enolase superfamily member 1) | Using a linear mixed model, differential expression with age was identified in ENOSF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ENOX1 (ecto-NOX disulfide-thiol exchanger 1) | Ageing related cell surface oxidase (arNOX) specific activity increases between age 30 and age 50 to 65. arNOX generates superoxide at cell surfaces and in the circulation. | Male | 30 | 60 | Skin | 2646: Morré et al. (2008) "Age-related ENOX protein (arNOX) activity correlated with oxidative skin damage in the elderly." Biofactors 34(3):237-244 (19734125) | ||
| ENSA (endosulfine alpha) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) | Male and Female | 6 | 22 | Liver | 23.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Entpd7 (ectonucleoside triphosphate diphosphohydrolase 7) | Male and Female | 8 | 24 | Muscle | -9.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| EP300 (E1A binding protein p300) | Gene expression showed a significant (p<E-3) decrease in the expression of EP300 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -69.23 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| EP400 (E1A binding protein p400) | Using a linear mixed model, differential expression with age was identified in EP400 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Epb4.1l3 (erythrocyte protein band 4.1-like 3) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| EPB41 (erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)) | Gene expression showed a significant (p<E-3) decrease in the expression of EPB41 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -42.2 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| EPB41L2 (erythrocyte membrane protein band 4.1-like 2) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EPB41L5 (erythrocyte membrane protein band 4.1 like 5) | Using a linear mixed model, differential expression with age was identified in EPB41L5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EPB42 (erythrocyte membrane protein band 4.2) | Using a linear mixed model, differential expression with age was identified in EPB42 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Epc1 (enhancer of polycomb homolog 1 (Drosophila)) | Male and Female | 6 | 22 | Liver | 2.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| EPHB1 (EPH receptor B1) | Using a linear mixed model, differential expression with age was identified in EPHB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EPHB4 (EPH receptor B4) | Using a linear mixed model, differential expression with age was identified in EPHB4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EPHX1 (epoxide hydrolase 1, microsomal (xenobiotic)) | Using a linear mixed model, differential expression with age was identified in EPHX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EPHX2 (epoxide hydrolase 2, cytoplasmic) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of EPHX2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| EPHX3 (epoxide hydrolase 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of EPHX3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Eps8l1 (EPS8-like 1) | Male and Female | 5 | 22 | Brain | 152.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| EPS8L1 (EPS8-like 1) | Using a linear mixed model, differential expression with age was identified in EPS8L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Eral1 (Era (G-protein)-like 1 (E. coli)) | Male and Female | 5 | 25 | Skeletal Muscle | -2.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Erbb3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)) | Male and Female | 5 | 30 | Anatomical System | 8.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| ERCC1 (excision repair cross-complementation group 1) | Using a linear mixed model, differential expression with age was identified in ERCC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERCC5 (excision repair cross-complementation group 5) | Using a linear mixed model, differential expression with age was identified in ERCC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERGIC3 (ERGIC and golgi 3) | Using a linear mixed model, differential expression with age was identified in ERGIC3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERI1 (exoribonuclease 1) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396) | |
| ERICH1 (glutamate-rich 1) | Gene expression showed a significant (p<E-3) increase in the expression of ERICH1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 59.0 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) | |
| ERMP1 (endoplasmic reticulum metallopeptidase 1) | Using a linear mixed model, differential expression with age was identified in ERMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERN1 (endoplasmic reticulum to nucleus signaling 1) | Using a linear mixed model, differential expression with age was identified in ERN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERP29 (endoplasmic reticulum protein 29) | Using a linear mixed model, differential expression with age was identified in ERP29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ERV3-1 (endogenous retrovirus group 3, member 1) | Using a linear mixed model, differential expression with age was identified in ERV3-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ESR2 (estrogen receptor 2 (ER beta)) | Male and Female | 22 | 73 | Skeletal Muscle | 5.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| ESRP2 (epithelial splicing regulatory protein 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ESRP2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ESRRA (estrogen-related receptor alpha) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Etf1 (eukaryotic translation termination factor 1) | Male and Female | 5 | 25 | Skeletal Muscle | 2.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Etv1 (ets variant gene 1) | Male and Female | 3 | 23 | Hematological System | -35.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| ETV4 (ets variant 4) | Using a linear mixed model, differential expression with age was identified in ETV4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ETV6 (ets variant 6) | Using a linear mixed model, differential expression with age was identified in ETV6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EVA1B (eva-1 homolog B (C. elegans)) | Using a linear mixed model, differential expression with age was identified in EVA1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EWSR1 (EWS RNA-binding protein 1) | Using a linear mixed model, differential expression with age was identified in EWSR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Exoc6b (exocyst complex component 6B) | Male and Female | 3 | 23 | Hematological System | 11.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| EXOC7 (exocyst complex component 7) | Using a linear mixed model, differential expression with age was identified in EXOC7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EXOSC10 (exosome component 10) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| EXOSC10 (exosome component 10) | Using a linear mixed model, differential expression with age was identified in EXOSC10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| EXOSC4 (exosome component 4) | Using a linear mixed model, differential expression with age was identified in EXOSC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Exosc7 (exosome component 7) | Male and Female | 8 | 24 | Muscle | -7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Ext1 (exostoses (multiple) 1) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Extl1 (exostoses (multiple)-like 1) | Male and Female | 8 | 24 | Muscle | -7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| F13a1 (coagulation factor XIII, A1 subunit) | Male and Female | 2 | 26 | Lung | 8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| F5 (coagulation factor V (proaccelerin, labile factor)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of F5 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| FA2H (fatty acid 2-hydroxylase) | Using a linear mixed model, differential expression with age was identified in FA2H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fabp4 (fatty acid binding protein 4, adipocyte) | Male and Female | 2 | 24 | Visual Apparatus | 188.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| Fabp5 (fatty acid binding protein 5, epidermal) | Male and Female | 2 | 24 | Visual Apparatus | 259.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| FABP9 (fatty acid binding protein 9, testis) | Using a linear mixed model, differential expression with age was identified in FABP9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FADS1 (fatty acid desaturase 1) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FADS1 (fatty acid desaturase 1) | Using a linear mixed model, differential expression with age was identified in FADS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FADS3 (fatty acid desaturase 3) | Using a linear mixed model, differential expression with age was identified in FADS3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAH (fumarylacetoacetate hydrolase (fumarylacetoacetase)) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FAIM2 (Fas apoptotic inhibitory molecule 2) | Using a linear mixed model, differential expression with age was identified in FAIM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM111A (family with sequence similarity 111, member A) | Using a linear mixed model, differential expression with age was identified in FAM111A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fam114a1 (family with sequence similarity 114, member A1) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FAM124B (family with sequence similarity 124B) | Using a linear mixed model, differential expression with age was identified in FAM124B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM127A (family with sequence similarity 127, member A) | Using a linear mixed model, differential expression with age was identified in FAM127A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM129B (family with sequence similarity 129, member B) | Using a linear mixed model, differential expression with age was identified in FAM129B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM131A (family with sequence similarity 131, member A) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FAM131A (family with sequence similarity 131, member A) | Using a linear mixed model, differential expression with age was identified in FAM131A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fam132a (family with sequence similarity 132, member A) | Male and Female | 5 | 30 | Anatomical System | -7.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| FAM133B (family with sequence similarity 133, member B) | Using a linear mixed model, differential expression with age was identified in FAM133B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM135A (family with sequence similarity 135, member A) | Using a linear mixed model, differential expression with age was identified in FAM135A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fam13b (family with sequence similarity 13, member B) | Male and Female | 5 | 25 | Skeletal Muscle | 4.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| FAM160B1 (family with sequence similarity 160, member B1) | Using a linear mixed model, differential expression with age was identified in FAM160B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM162A (family with sequence similarity 162, member A) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Fam162b (family with sequence similarity 162, member B) | Male and Female | 2 | 26 | Lung | -14.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FAM173A (family with sequence similarity 173, member A) | Using a linear mixed model, differential expression with age was identified in FAM173A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM174B (family with sequence similarity 174, member B) | Male and Female | 20 | 75 | Skeletal Muscle | 9.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Fam176b (family with sequence similarity 176, member B) | Male and Female | 5 | 22 | Brain | -9.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| FAM189A2 (family with sequence similarity 189, member A2) | Using a linear mixed model, differential expression with age was identified in FAM189A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fam19a5 (family with sequence similarity 19, member A5) | Male and Female | 8 | 24 | Muscle | 9.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| FAM209B (family with sequence similarity 209, member B) | Using a linear mixed model, differential expression with age was identified in FAM209B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM24B (family with sequence similarity 24, member B) | Using a linear mixed model, differential expression with age was identified in FAM24B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM43B (family with sequence similarity 43, member B) | Using a linear mixed model, differential expression with age was identified in FAM43B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM46B (family with sequence similarity 46, member B) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FAM46B and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| FAM46C (family with sequence similarity 46, member C) | Using a linear mixed model, differential expression with age was identified in FAM46C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM49A (family with sequence similarity 49, member A) | Male and Female | 26 | 106 | Brain | -16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FAM63A (family with sequence similarity 63, member A) | Using a linear mixed model, differential expression with age was identified in FAM63A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM69A (family with sequence similarity 69, member A) | Using a linear mixed model, differential expression with age was identified in FAM69A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM69C (family with sequence similarity 69, member C) | Using a linear mixed model, differential expression with age was identified in FAM69C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM71E1 (family with sequence similarity 71, member E1) | Using a linear mixed model, differential expression with age was identified in FAM71E1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM83A (family with sequence similarity 83, member A) | Using a linear mixed model, differential expression with age was identified in FAM83A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fam83h (family with sequence similarity 83, member H) | Male and Female | 5 | 25 | Skeletal Muscle | -3.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| FAM84B (family with sequence similarity 84, member B) | Using a linear mixed model, differential expression with age was identified in FAM84B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM89B (family with sequence similarity 89, member B) | Using a linear mixed model, differential expression with age was identified in FAM89B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAM96A (family with sequence similarity 96, member A) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FANCD2 (Fanconi anemia, complementation group D2) | Using a linear mixed model, differential expression with age was identified in FANCD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAR2 (fatty acyl CoA reductase 2) | Using a linear mixed model, differential expression with age was identified in FAR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FASTK (Fas-activated serine/threonine kinase) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FASTK (Fas-activated serine/threonine kinase) | Using a linear mixed model, differential expression with age was identified in FASTK in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAT2 (FAT atypical cadherin 2) | Using a linear mixed model, differential expression with age was identified in FAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAXDC2 (fatty acid hydroxylase domain containing 2) | Using a linear mixed model, differential expression with age was identified in FAXDC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FAXDC2 (fatty acid hydroxylase domain containing 2) | Using a linear mixed model, differential expression with age was identified in FAXDC2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBLN1 (fibulin 1) | Using a linear mixed model, differential expression with age was identified in FBLN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBLN5 (fibulin 5) | Using a linear mixed model, differential expression with age was identified in FBLN5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fbn2 (fibrillin 2) | Male and Female | 8 | 24 | Muscle | -31.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| FBP1 (fructose-1,6-bisphosphatase 1) | Using a linear mixed model, differential expression with age was identified in FBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBP2 (fructose-1,6-bisphosphatase 2) | Using a linear mixed model, differential expression with age was identified in FBP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBXL16 (F-box and leucine-rich repeat protein 16) | Gene expression showed a significant (p<E-3) decrease in the expression of FBXL16 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -51.69 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| FBXL6 (F-box and leucine-rich repeat protein 6) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of FBXL6 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| FBXO11 (F-box protein 11) | Using a linear mixed model, differential expression with age was identified in FBXO11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBXO22 (F-box protein 22) | Using a linear mixed model, differential expression with age was identified in FBXO22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FBXO31 (F-box protein 31) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FBXW12 (F-box and WD repeat domain containing 12) | Male and Female | 20 | 75 | Skeletal Muscle | 9.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Fbxw4 (F-box and WD-40 domain protein 4) | Male and Female | 3 | 23 | Hematological System | -12.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase) | Using a linear mixed model, differential expression with age was identified in FBXW7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 144.23 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 342.83 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 187.24 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 105.27 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 98.14 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 222.59 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 177.42 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCER1G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 111.38 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGBP (Fc fragment of IgG binding protein) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 138.31 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGBP (Fc fragment of IgG binding protein) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 290.6 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGBP (Fc fragment of IgG binding protein) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGBP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 212.37 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 150.96 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 423.11 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 157.35 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR1A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 207.57 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 166.0 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 434.19 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 225.53 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR1B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 170.41 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 124.01 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 316.44 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 141.5 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR2A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 104.3 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)) | CD16 is a receptor for the Fc part of immunoglobulin G (IgG). Its expression was reduced in neutrophils from elderly donors. | Male and Female | -1 | -1 | Neutrophil | 2850: Butcher et al. (2001) "Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans." J. Leukoc. Biol. 70(6):881-886 (11739550) | ||
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 647.0 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 404.56 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 261.05 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 80.84 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 131.12 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGR3B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 52.13 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGRT (Fc fragment of IgG, receptor, transporter, alpha) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe FCGRT from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 76.72 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCGRT (Fc fragment of IgG, receptor, transporter, alpha) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe FCGRT from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 89.34 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| FCN1 (ficolin (collagen/fibrinogen domain containing) 1) | Using a linear mixed model, differential expression with age was identified in FCN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FDFT1 (farnesyl-diphosphate farnesyltransferase 1) | Using a linear mixed model, differential expression with age was identified in FDFT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FDPS (farnesyl diphosphate synthase) | Using a linear mixed model, differential expression with age was identified in FDPS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fdps (farnesyl diphosphate synthetase) | Male and Female | 8 | 24 | Muscle | -7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| FDX1 (ferredoxin 1) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Fermt3 (fermitin family homolog 3 (Drosophila)) | Male and Female | 2 | 26 | Lung | 14.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FETUB (fetuin B) | Using a linear mixed model, differential expression with age was identified in FETUB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FEV (FEV (ETS oncogene family)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FEV and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| FEZ1 (fasciculation and elongation protein zeta 1 (zygin I)) | Using a linear mixed model, differential expression with age was identified in FEZ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FEZ2 (fasciculation and elongation protein zeta 2 (zygin II)) | Male and Female | 22 | 73 | Skeletal Muscle | 5.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| FGF1 (fibroblast growth factor 1 (acidic)) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FGF12 (fibroblast growth factor 12) | Male and Female | 26 | 106 | Brain | -29.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Fgf13 (fibroblast growth factor 13) | Male and Female | 2 | 26 | Lung | 28.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FGF13 (fibroblast growth factor 13) | Male and Female | 26 | 106 | Brain | -28.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FGF2 (fibroblast growth factor 2 (basic)) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FGF8 (fibroblast growth factor 8 (androgen-induced)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FGF8 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| FGFR3 (fibroblast growth factor receptor 3) | Male and Female | 26 | 106 | Brain | 13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| FGFR3 (fibroblast growth factor receptor 3) | Using a linear mixed model, differential expression with age was identified in FGFR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fggy (FGGY carbohydrate kinase domain containing) | Male and Female | 5 | 25 | Skeletal Muscle | 17.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| FGL2 (fibrinogen-like 2) | Using a linear mixed model, differential expression with age was identified in FGL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FGL2 (fibrinogen-like 2) | Using a linear mixed model, differential expression with age was identified in FGL2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FH (fumarate hydratase) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Fhod1 (formin homology 2 domain containing 1) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FIGN (fidgetin) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FIGN and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| FILIP1 (filamin A interacting protein 1) | Using a linear mixed model, differential expression with age was identified in FILIP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FIP1L1 (factor interacting with PAPOLA and CPSF1) | Using a linear mixed model, differential expression with age was identified in FIP1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FIS1 (fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in FIS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FJX1 (four jointed box 1 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in FJX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FKBP1A (FK506 binding protein 1A, 12kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FLNB (filamin B, beta) | Using a linear mixed model, differential expression with age was identified in FLNB in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FLT1 (fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor recep) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FLT4 (fms-related tyrosine kinase 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of FLT4 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Fmc1 (formation of mitochondrial complexes 1 homolog (S. cerevisiae)) | Male and Female | 5 | 30 | Anatomical System | -1.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| FMO3 (flavin containing monooxygenase 3) | Using a linear mixed model, differential expression with age was identified in FMO3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FMO3 (flavin containing monooxygenase 3) | Using a linear mixed model, differential expression with age was identified in FMO3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FNDC4 (fibronectin type III domain containing 4) | Using a linear mixed model, differential expression with age was identified in FNDC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FNDC5 (fibronectin type III domain containing 5) | Using a linear mixed model, differential expression with age was identified in FNDC5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FOCAD (focadhesin) | Using a linear mixed model, differential expression with age was identified in FOCAD in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FOLR2 (folate receptor 2 (fetal)) | Using a linear mixed model, differential expression with age was identified in FOLR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fosb (FBJ osteosarcoma oncogene B) | Male and Female | 2 | 26 | Lung | -13.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Fosl2 (fos-like antigen 2) | Male and Female | 6 | 22 | Liver | -40.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Foxa3 (forkhead box A3) | Male and Female | 6 | 22 | Liver | 13.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| FOXC1 (forkhead box C1) | Using a linear mixed model, differential expression with age was identified in FOXC1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FOXJ3 (forkhead box J3) | Using a linear mixed model, differential expression with age was identified in FOXJ3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Foxl1 (forkhead box L1) | Male and Female | 5 | 25 | Skeletal Muscle | -1.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| FOXO1 (forkhead box O1) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FOXP1 (forkhead box P1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of FOXP1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| FOXQ1 (forkhead box Q1) | Using a linear mixed model, differential expression with age was identified in FOXQ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Foxred2 (FAD-dependent oxidoreductase domain containing 2) | Male and Female | 2 | 26 | Lung | 89.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FRMD3 (FERM domain containing 3) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FRMPD4 (FERM and PDZ domain containing 4) | Male and Female | 26 | 106 | Brain | -22.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Fryl (furry homolog-like (Drosophila)) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Frzb (frizzled-related protein) | Male and Female | 8 | 24 | Muscle | -12.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| FST (follistatin) | Male and Female | 20 | 75 | Skeletal Muscle | 8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| FSTL1 (follistatin-like 1) | Expression level of miR-198 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 74.25246561 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| FTO (fat mass and obesity associated) | Using a linear mixed model, differential expression with age was identified in FTO in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FTSJ1 (FtsJ RNA methyltransferase homolog 1 (E. coli)) | Using a linear mixed model, differential expression with age was identified in FTSJ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FUK (fucokinase) | Using a linear mixed model, differential expression with age was identified in FUK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| FUT3 (fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of FUT3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Fut9 (fucosyltransferase 9) | Male and Female | 5 | 22 | Brain | -2.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| FXYD2 (FXYD domain containing ion transport regulator 2) | Male and Female | 27 | 92 | Kidney | -5.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| FXYD6 (FXYD domain containing ion transport regulator 6) | Using a linear mixed model, differential expression with age was identified in FXYD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Fzd2 (frizzled homolog 2 (Drosophila)) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| FZD9 (frizzled class receptor 9) | Using a linear mixed model, differential expression with age was identified in FZD9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| G6PC3 (glucose 6 phosphatase, catalytic, 3) | Using a linear mixed model, differential expression with age was identified in G6PC3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| G6PD (glucose-6-phosphate dehydrogenase) | Using a linear mixed model, differential expression with age was identified in G6PD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gab1 (growth factor receptor bound protein 2-associated protein 1) | Male and Female | 8 | 24 | Muscle | -3.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2) | Using a linear mixed model, differential expression with age was identified in GABBR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gabra3 (gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3) | Male and Female | 5 | 30 | Anatomical System | 5.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Gabra4 (gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4) | Male and Female | 3 | 23 | Hematological System | 252.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| GABRB3 (gamma-aminobutyric acid (GABA) A receptor, beta 3) | Male and Female | 26 | 106 | Brain | -31.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| GABRD (gamma-aminobutyric acid (GABA) A receptor, delta) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| GABRE (gamma-aminobutyric acid (GABA) A receptor, epsilon) | Using a linear mixed model, differential expression with age was identified in GABRE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gad1 (glutamic acid decarboxylase 1) | Male and Female | 5 | 30 | Anatomical System | 1.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of GAD2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| GADD45A (growth arrest and DNA-damage-inducible, alpha) | Male and Female | 20 | 75 | Skeletal Muscle | 19.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16) | Using a linear mixed model, differential expression with age was identified in GALNT16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16) | Using a linear mixed model, differential expression with age was identified in GALNT16 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GAP43 (growth associated protein 43) | Using a linear mixed model, differential expression with age was identified in GAP43 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GAP43 (growth associated protein 43) | Using a linear mixed model, differential expression with age was identified in GAP43 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gapdhs (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic) | Male and Female | 6 | 22 | Liver | -14.0 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | ||
| Gas2l2 (growth arrest-specific 2 like 2) | Male and Female | 2 | 26 | Lung | 15.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gas2l3 (growth arrest-specific 2 like 3) | Male and Female | 3 | 23 | Hematological System | 14.0 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | ||
| GAS2L3 (growth arrest-specific 2 like 3) | Male and Female | 0 | 102 | Cerebellum | 0.0 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | ||
| GAS2L3 (growth arrest-specific 2 like 3) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | ||
| GAS2L3 (growth arrest-specific 2 like 3) | Male and Female | 0 | 102 | Pons | 0.0 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | ||
| GAS2L3 (growth arrest-specific 2 like 3) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | ||
| Gas5 (growth arrest specific 5) | Male and Female | 2 | 15 | Hippocampus | 2.0 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | ||
| GAS6 (growth arrest-specific 6) | Using a linear mixed model, differential expression with age was identified in GAS6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GATM (glycine amidinotransferase (L-arginine:glycine amidinotransferase)) | Male and Female | 26 | 106 | Brain | 8.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GBP1 (guanylate binding protein 1, interferon-inducible) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GBP1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| GBP4 (guanylate binding protein 4) | Using a linear mixed model, differential expression with age was identified in GBP4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gcat (glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)) | Male and Female | 5 | 25 | Skeletal Muscle | 10.0 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | ||
| GCDH (glutaryl-CoA dehydrogenase) | Using a linear mixed model, differential expression with age was identified in GCDH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GCHFR (GTP cyclohydrolase I feedback regulator) | Using a linear mixed model, differential expression with age was identified in GCHFR in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gclc (glutamate-cysteine ligase, catalytic subunit) | The apparent Km for cysteine and glutamine of the glutamate-cysteine ligase (GCL) were, respectively, 300 and 450 mM in the young (6-month-old) and 800 and 710 mM in the old mice (24-month-old). | Male and Female | 6 | 12 | Liver | 2825: Rebrin and Sohal (2008) "Pro-oxidant shift in glutathione redox state during aging." Adv. Drug Deliv. Rev. 60(13-14):1545-1552 (18652861)|2851: Toroser et al. (2006) "Mechanisms of gamma-glutamylcysteine ligase regulation." Biochim. Biophys. Acta 1760(2):233-244 (16324789) | ||
| GCM2 (glial cells missing homolog 2 (Drosophila)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GCM2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Gcsh (glycine cleavage system protein H (aminomethyl carrier)) | Male and Female | 8 | 24 | Muscle | 4.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GCSH (glycine cleavage system protein H (aminomethyl carrier)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GDA (guanine deaminase) | Male and Female | 20 | 75 | Skeletal Muscle | 8.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GDE1 (glycerophosphodiester phosphodiesterase 1) | Using a linear mixed model, differential expression with age was identified in GDE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GDPD2 (glycerophosphodiester phosphodiesterase domain containing 2) | Using a linear mixed model, differential expression with age was identified in GDPD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gdpd5 (glycerophosphodiester phosphodiesterase domain containing 5) | Male and Female | 8 | 24 | Muscle | 23.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| Gem (GTP binding protein (gene overexpressed in skeletal muscle)) | Male and Female | 2 | 26 | Lung | -13.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gfap (glial fibrillary acidic protein) | Male and Female | 5 | 30 | Anatomical System | 11.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| Gfap (glial fibrillary acidic protein) | Male and Female | 2 | 15 | Hippocampus | 4.0 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | ||
| GFPT2 (glutamine-fructose-6-phosphate transaminase 2) | Using a linear mixed model, differential expression with age was identified in GFPT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GFRA2 (GDNF family receptor alpha 2) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Gfra2 (glial cell line derived neurotrophic factor family receptor alpha 2) | Male and Female | 8 | 24 | Muscle | -4.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GGA3 (golgi-associated, gamma adaptin ear containing, ARF binding protein 3) | Using a linear mixed model, differential expression with age was identified in GGA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GGNBP2 (gametogenetin binding protein 2) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ggt1 (gamma-glutamyltransferase 1) | Male and Female | 2 | 26 | Lung | 7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| GGT5 (gamma-glutamyltransferase 5) | Using a linear mixed model, differential expression with age was identified in GGT5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GGT6 (gamma-glutamyltransferase 6) | Using a linear mixed model, differential expression with age was identified in GGT6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GHDC (GH3 domain containing) | Using a linear mixed model, differential expression with age was identified in GHDC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GHDC (GH3 domain containing) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GHDC and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| GHITM (growth hormone inducible transmembrane protein) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of GIT1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Gkap1 (G kinase anchoring protein 1) | Male and Female | 8 | 24 | Muscle | 8.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GLB1 (galactosidase, beta 1) | Using a linear mixed model, differential expression with age was identified in GLB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GLDC (glycine dehydrogenase (decarboxylating)) | Using a linear mixed model, differential expression with age was identified in GLDC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GLG1 (golgi apparatus protein 1) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GLG1 (golgi apparatus protein 1) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| Glo1 (glyoxalase 1) | Male and Female | 8 | 24 | Muscle | -3.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GLRA1 (glycine receptor, alpha 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GLRA1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| GLRX2 (glutaredoxin 2) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GLRX5 (glutaredoxin 5) | Using a linear mixed model, differential expression with age was identified in GLRX5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gltp (glycolipid transfer protein) | Male and Female | 5 | 30 | Anatomical System | 5.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| Gm11346 (predicted gene 11346) | Male and Female | 2 | 26 | Lung | 55.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Gm885 (predicted gene 885) | Male and Female | 5 | 22 | Brain | 674.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| GMDS (GDP-mannose 4,6-dehydratase) | Using a linear mixed model, differential expression with age was identified in GMDS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gna11 (guanine nucleotide binding protein, alpha 11) | Male and Female | 8 | 24 | Muscle | 2.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GNA12 (guanine nucleotide binding protein (G protein) alpha 12) | Using a linear mixed model, differential expression with age was identified in GNA12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2) | Gene expression showed a significant (p<E-3) increase in the expression of GNAI2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 58.0 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) | |
| GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1) | Male and Female | 26 | 106 | Brain | -4.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GNB5 (guanine nucleotide binding protein (G protein), beta 5) | Male and Female | 26 | 106 | Brain | -17.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GNG11 (guanine nucleotide binding protein (G protein), gamma 11) | Male and Female | 26 | 106 | Brain | 23.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GNG12 (guanine nucleotide binding protein (G protein), gamma 12) | Male and Female | 26 | 106 | Brain | 19.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GNG2 (guanine nucleotide binding protein (G protein), gamma 2) | Gene expression showed a significant (p<E-3) decrease in the expression of GNG2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -45.65 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) | |
| GNG5 (guanine nucleotide binding protein (G protein), gamma 5) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GNPAT (glyceronephosphate O-acyltransferase) | Using a linear mixed model, differential expression with age was identified in GNPAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GNPDA1 (glucosamine-6-phosphate deaminase 1) | Male and Female | 22 | 73 | Skeletal Muscle | 3.0 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | ||
| Gnpda1 (glucosamine-6-phosphate deaminase 1) | Male and Female | 6 | 22 | Liver | -6.0 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | ||
| GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)) | Using a linear mixed model, differential expression with age was identified in GNRH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GNRH2 (gonadotropin-releasing hormone 2) | Using a linear mixed model, differential expression with age was identified in GNRH2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GNRHR2 (gonadotropin-releasing hormone (type 2) receptor 2) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| Gns (glucosamine (N-acetyl)-6-sulfatase) | Male and Female | 8 | 24 | Muscle | 3.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GOLGB1 (golgin B1) | Using a linear mixed model, differential expression with age was identified in GOLGB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GOLPH3L (golgi phosphoprotein 3-like) | Using a linear mixed model, differential expression with age was identified in GOLPH3L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GOT1 (glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)) | Using a linear mixed model, differential expression with age was identified in GOT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GOT1 (glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| GOT2 (glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| Gp1ba (glycoprotein 1b, alpha polypeptide) | Male and Female | 2 | 26 | Lung | 20.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gp1bb (glycoprotein Ib, beta polypeptide) | Male and Female | 2 | 26 | Lung | 22.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gp5 (glycoprotein 5 (platelet)) | Male and Female | 2 | 26 | Lung | 15.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gp6 (glycoprotein 6 (platelet)) | Male and Female | 2 | 26 | Lung | 16.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| GPC1 (glypican 1) | Using a linear mixed model, differential expression with age was identified in GPC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPC2 (glypican 2) | Using a linear mixed model, differential expression with age was identified in GPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPC6 (glypican 6) | Using a linear mixed model, differential expression with age was identified in GPC6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gpcpd1 (glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)) | Male and Female | 2 | 26 | Lung | 8.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Gpd1 (glycerol-3-phosphate dehydrogenase 1 (soluble)) | Male and Female | 8 | 24 | Muscle | -6.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GPHN (gephyrin) | Using a linear mixed model, differential expression with age was identified in GPHN in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPI (glucose-6-phosphate isomerase) | Using a linear mixed model, differential expression with age was identified in GPI in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPN2 (GPN-loop GTPase 2) | Using a linear mixed model, differential expression with age was identified in GPN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPR128 (G protein-coupled receptor 128) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of GPR128 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| GPR137B (G protein-coupled receptor 137B) | Using a linear mixed model, differential expression with age was identified in GPR137B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPR137B (G protein-coupled receptor 137B) | Male and Female | 26 | 106 | Brain | 16.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GPR25 (G protein-coupled receptor 25) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GPR25 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| GPRC5B (G protein-coupled receptor, family C, group 5, member B) | Male and Female | 26 | 106 | Brain | 10.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GPRC5D (G protein-coupled receptor, class C, group 5, member D) | Using a linear mixed model, differential expression with age was identified in GPRC5D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPT (glutamic-pyruvate transaminase (alanine aminotransferase)) | Using a linear mixed model, differential expression with age was identified in GPT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GPX3 (glutathione peroxidase 3 (plasma)) | Using a linear mixed model, differential expression with age was identified in GPX3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gpx3 (glutathione peroxidase 3) | Male and Female | 3 | 23 | Hematological System | 45.0 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | ||
| GPX4 (glutathione peroxidase 4) | Using a linear mixed model, differential expression with age was identified in GPX4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GRAMD2 (GRAM domain containing 2) | Using a linear mixed model, differential expression with age was identified in GRAMD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GRAMD3 (GRAM domain containing 3) | Using a linear mixed model, differential expression with age was identified in GRAMD3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Grcc10 (gene rich cluster, C10 gene) | Male and Female | 5 | 30 | Anatomical System | 3.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| GREB1 (growth regulation by estrogen in breast cancer 1) | Using a linear mixed model, differential expression with age was identified in GREB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GREB1L (growth regulation by estrogen in breast cancer-like) | Using a linear mixed model, differential expression with age was identified in GREB1L in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GREB1L (growth regulation by estrogen in breast cancer-like) | Using a linear mixed model, differential expression with age was identified in GREB1L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GREM1 (gremlin 1, DAN family BMP antagonist) | Using a linear mixed model, differential expression with age was identified in GREM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GREM1 (gremlin 1, DAN family BMP antagonist) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of GREM1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| GRHPR (glyoxylate reductase/hydroxypyruvate reductase) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| Grhpr (glyoxylate reductase/hydroxypyruvate reductase) | Male and Female | 8 | 24 | Muscle | -1.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GRIA1 (glutamate receptor, ionotropic, AMPA 1) | Male and Female | 26 | 106 | Brain | -17.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GRIA2 (glutamate receptor, ionotropic, AMPA 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of GRIA2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| GRIN2A (glutamate receptor, ionotropic, N-methyl D-aspartate 2A) | Male and Female | 26 | 106 | Brain | -18.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GRIN2D (glutamate receptor, ionotropic, N-methyl D-aspartate 2D) | Male and Female | 26 | 106 | Brain | -7.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GRP (gastrin-releasing peptide) | Using a linear mixed model, differential expression with age was identified in GRP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GRTP1 (growth hormone regulated TBC protein 1) | Using a linear mixed model, differential expression with age was identified in GRTP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GSDMB (gasdermin B) | Using a linear mixed model, differential expression with age was identified in GSDMB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GSDMC (gasdermin C) | Using a linear mixed model, differential expression with age was identified in GSDMC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gse1 (genetic suppressor element 1) | Male and Female | 5 | 30 | Anatomical System | -31.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| GSTA1 (glutathione S-transferase alpha 1) | Using a linear mixed model, differential expression with age was identified in GSTA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GSTM2 (glutathione S-transferase mu 2 (muscle)) | Using a linear mixed model, differential expression with age was identified in GSTM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GTDC1 (glycosyltransferase-like domain containing 1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| Gtf2i (general transcription factor II I) | Male and Female | 2 | 15 | Hippocampus | -1.0 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | ||
| GTF3C2 (general transcription factor IIIC, polypeptide 2, beta 110kDa) | Using a linear mixed model, differential expression with age was identified in GTF3C2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gtpbp2 (GTP binding protein 2) | Male and Female | 8 | 24 | Muscle | -2.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| GTPBP3 (GTP binding protein 3 (mitochondrial)) | Using a linear mixed model, differential expression with age was identified in GTPBP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GUCA1B (guanylate cyclase activator 1B (retina)) | Using a linear mixed model, differential expression with age was identified in GUCA1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GUK1 (guanylate kinase 1) | Male and Female | 26 | 106 | Brain | -5.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| GYLTL1B (glycosyltransferase-like 1B) | Using a linear mixed model, differential expression with age was identified in GYLTL1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GYPC (glycophorin C (Gerbich blood group)) | Using a linear mixed model, differential expression with age was identified in GYPC in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GYPC (glycophorin C (Gerbich blood group)) | Using a linear mixed model, differential expression with age was identified in GYPC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) | Using a linear mixed model, differential expression with age was identified in GZMH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) | Using a linear mixed model, differential expression with age was identified in GZMH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Gzmm (granzyme M (lymphocyte met-ase 1)) | Male and Female | 2 | 26 | Lung | 16.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| H2-Aa (histocompatibility 2, class II antigen A, alpha) | Male and Female | 6 | 22 | Liver | 53.0 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | ||
| H2-Ab1 (histocompatibility 2, class II antigen A, beta 1) | Male and Female | 6 | 22 | Liver | 30.0 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | ||
| H2AFJ (H2A histone family, member J) | Using a linear mixed model, differential expression with age was identified in H2AFJ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| H2AFJ (H2A histone family, member J) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| H3F3B (H3 histone, family 3B (H3.3B)) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HABP4 (hyaluronan binding protein 4) | Using a linear mixed model, differential expression with age was identified in HABP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HADH (hydroxyacyl-CoA dehydrogenase) | Using a linear mixed model, differential expression with age was identified in HADH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HAO2 (hydroxyacid oxidase 2 (long chain)) | Using a linear mixed model, differential expression with age was identified in HAO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HARS2 (histidyl-tRNA synthetase 2, mitochondrial) | Using a linear mixed model, differential expression with age was identified in HARS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HAS3 (hyaluronan synthase 3) | Gene expression showed a significant (p<E-3) increase in the expression of HAS3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 60.0 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) | |
| HAUS7 (HAUS augmin-like complex, subunit 7) | Using a linear mixed model, differential expression with age was identified in HAUS7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HBEGF (heparin-binding EGF-like growth factor) | Using a linear mixed model, differential expression with age was identified in HBEGF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HCCS (holocytochrome c synthase (cytochrome c heme-lyase)) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HCCS (holocytochrome c synthase (cytochrome c heme-lyase)) | Male and Female | 26 | 106 | Brain | -14.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HCLS1 (hematopoietic cell-specific Lyn substrate 1) | Using a linear mixed model, differential expression with age was identified in HCLS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HCP5 (HLA complex P5 (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in HCP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HCP5 (HLA complex P5 (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in HCP5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HDAC4 (histone deacetylase 4) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HEATR4 (HEAT repeat containing 4) | Using a linear mixed model, differential expression with age was identified in HEATR4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HEY2 (hes-related family bHLH transcription factor with YRPW motif 2) | Using a linear mixed model, differential expression with age was identified in HEY2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Heyl (hairy/enhancer-of-split related with YRPW motif-like) | Male and Female | 8 | 24 | Muscle | -4.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| HIBCH (3-hydroxyisobutyryl-CoA hydrolase) | Using a linear mixed model, differential expression with age was identified in HIBCH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIGD1B (HIG1 hypoxia inducible domain family, member 1B) | Using a linear mixed model, differential expression with age was identified in HIGD1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HILPDA (hypoxia inducible lipid droplet-associated) | Using a linear mixed model, differential expression with age was identified in HILPDA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HINT1 (histidine triad nucleotide binding protein 1) | Male and Female | 26 | 106 | Brain | -5.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HIPK2 (homeodomain interacting protein kinase 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of HIPK2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HIST1H1C (histone cluster 1, H1c) | Using a linear mixed model, differential expression with age was identified in HIST1H1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hist1h1c (histone cluster 1, H1c) | Male and Female | 2 | 26 | Lung | 7.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| Hist1h1c (histone cluster 1, H1c) | Male and Female | 6 | 22 | Liver | 26.0 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | ||
| HIST1H2BD (histone cluster 1, H2bd) | Using a linear mixed model, differential expression with age was identified in HIST1H2BD in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIST1H2BD (histone cluster 1, H2bd) | Using a linear mixed model, differential expression with age was identified in HIST1H2BD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIST1H2BK (histone cluster 1, H2bk) | Using a linear mixed model, differential expression with age was identified in HIST1H2BK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hist1h3a (histone cluster 1, H3a) | Male and Female | 2 | 26 | Lung | 11.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| HIST1H4H (histone cluster 1, H4h) | Using a linear mixed model, differential expression with age was identified in HIST1H4H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIST2H2BE (histone cluster 2, H2be) | Using a linear mixed model, differential expression with age was identified in HIST2H2BE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIST3H2A (histone cluster 3, H2a) | Using a linear mixed model, differential expression with age was identified in HIST3H2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HIVEP3 (human immunodeficiency virus type I enhancer binding protein 3) | Using a linear mixed model, differential expression with age was identified in HIVEP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hjurp (Holliday junction recognition protein) | Male and Female | 2 | 26 | Lung | 4.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| HLA-B (major histocompatibility complex, class I, B) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 34.98 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-B (major histocompatibility complex, class I, B) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 36.48 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-B (major histocompatibility complex, class I, B) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 43.98 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-B (major histocompatibility complex, class I, B) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 38.96 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 39.81 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 32.6 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 37.72 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 40.14 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 38.88 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 37.81 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 34.85 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 36.98 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 56.51 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 32.79 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-C (major histocompatibility complex, class I, C) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-C from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 44.0 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMA (major histocompatibility complex, class II, DM alpha) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 110.56 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMA (major histocompatibility complex, class II, DM alpha) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 221.51 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMA (major histocompatibility complex, class II, DM alpha) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 169.94 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMA (major histocompatibility complex, class II, DM alpha) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DMA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 115.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMB (major histocompatibility complex, class II, DM beta) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DMB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 90.51 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DMB (major histocompatibility complex, class II, DM beta) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DMB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 56.95 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Using a linear mixed model, differential expression with age was identified in HLA-DPA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 210.32 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 262.92 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 124.35 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 169.04 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 97.14 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 35.77 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 153.21 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 160.52 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 13.18 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 81.55 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DPB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 76.89 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 496.71 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DQA1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 203.67 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 135.36 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DQB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 105.97 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 317.66 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 146.66 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 241.65 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 146.81 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 150.4 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 324.53 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 303.68 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRA (major histocompatibility complex, class II, DR alpha) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 135.28 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 193.49 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 90.28 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 82.98 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 204.16 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 111.08 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 84.78 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 177.65 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 100.42 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 88.46 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 95.76 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 183.97 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB5 (major histocompatibility complex, class II, DR beta 5) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-DRB5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 64.14 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB6 (major histocompatibility complex, class II, DR beta 6 (pseudogene)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-DRB6 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 150.16 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-DRB6 (major histocompatibility complex, class II, DR beta 6 (pseudogene)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-DRB6 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 33.5 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 76.64 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 58.3 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 39.23 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 43.93 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 34.88 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 41.65 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 65.73 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 61.18 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-E (major histocompatibility complex, class I, E) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-E from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 76.89 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-F (major histocompatibility complex, class I, F) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-F from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 28.92 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| HLA-G (major histocompatibility complex, class I, G) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 30.56 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| HLA-G (major histocompatibility complex, class I, G) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 30.53 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| HLA-G (major histocompatibility complex, class I, G) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 25.96 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| HLA-G (major histocompatibility complex, class I, G) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe HLA-G from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 28.42 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)) | Using a linear mixed model, differential expression with age was identified in HLCS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HLF (hepatic leukemia factor) | Male and Female | 26 | 106 | Brain | -10.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HMGB2 (high mobility group box 2) | Using a linear mixed model, differential expression with age was identified in HMGB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HMGCL (3-hydroxymethyl-3-methylglutaryl-CoA lyase) | Using a linear mixed model, differential expression with age was identified in HMGCL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)) | Using a linear mixed model, differential expression with age was identified in HMGCS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HMGN2 (high-mobility group nucleosomal binding domain 2) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HN1 (hematological and neurological expressed 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HNRNPC (heterogeneous nuclear ribonucleoprotein C (C1/C2)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) | Using a linear mixed model, differential expression with age was identified in HNRNPD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HNRNPDL (heterogeneous nuclear ribonucleoprotein D-like) | Using a linear mixed model, differential expression with age was identified in HNRNPDL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HNRNPM (heterogeneous nuclear ribonucleoprotein M) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HOOK2 (hook microtubule-tethering protein 2) | Using a linear mixed model, differential expression with age was identified in HOOK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HOXA9 (homeobox A9) | Using a linear mixed model, differential expression with age was identified in HOXA9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HOXB1 (homeobox B1) | Comparison of DNA methylation showed a significantly decreased methylation level of HOXB1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.6 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) | |
| HOXB1 (homeobox B1) | Comparison of DNA methylation showed a significantly decreased methylation level of HOXB1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -49.3 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) | |
| Hoxb4 (homeobox B4) | Male and Female | 2 | 26 | Lung | -6.0 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | ||
| HOXB5 (homeobox B5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB5 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HOXB6 (homeobox B6) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB6 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HOXB7 (homeobox B7) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB7 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HOXB8 (homeobox B8) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of HOXB8 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HOXC4 (homeobox C4) | Using a linear mixed model, differential expression with age was identified in HOXC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HOXC6 (homeobox C6) | Using a linear mixed model, differential expression with age was identified in HOXC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HOXC8 (homeobox C8) | Using a linear mixed model, differential expression with age was identified in HOXC8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HOXD12 (homeobox D12) | Using a linear mixed model, differential expression with age was identified in HOXD12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HPCAL1 (hippocalcin-like 1) | Using a linear mixed model, differential expression with age was identified in HPCAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HPN (hepsin) | Male and Female | 22 | 73 | Skeletal Muscle | 4.0 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | ||
| HPS4 (Hermansky-Pudlak syndrome 4) | Using a linear mixed model, differential expression with age was identified in HPS4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HS3ST2 (heparan sulfate (glucosamine) 3-O-sulfotransferase 2) | Using a linear mixed model, differential expression with age was identified in HS3ST2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hsbp1 (heat shock factor binding protein 1) | Male and Female | 8 | 24 | Muscle | -2.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1) | Using a linear mixed model, differential expression with age was identified in HSD11B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10) | Using a linear mixed model, differential expression with age was identified in HSD17B10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD17B10 (hydroxysteroid (17-beta) dehydrogenase 10) | Using a linear mixed model, differential expression with age was identified in HSD17B10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD17B13 (hydroxysteroid (17-beta) dehydrogenase 13) | Using a linear mixed model, differential expression with age was identified in HSD17B13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD17B2 (hydroxysteroid (17-beta) dehydrogenase 2) | Using a linear mixed model, differential expression with age was identified in HSD17B2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7) | Male and Female | 8 | 24 | Muscle | 4.0 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | ||
| HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) | Using a linear mixed model, differential expression with age was identified in HSD3B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7) | Using a linear mixed model, differential expression with age was identified in HSD3B7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of HSD3B7 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| HSF1 (heat shock transcription factor 1) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HSF4 (heat shock transcription factor 4) | Using a linear mixed model, differential expression with age was identified in HSF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Hsfy2 (heat shock transcription factor, Y linked 2) | Male and Female | 5 | 22 | Brain | -81.0 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | ||
| Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1) | Male and Female | 5 | 30 | Anatomical System | -1.0 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | ||
| HSP90AB1 (heat shock protein 90kDa alpha (cytosolic), class B member 1) | Male and Female | 26 | 106 | Brain | -5.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HSPA12A (heat shock 70kDa protein 12A) | Using a linear mixed model, differential expression with age was identified in HSPA12A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HSPA1A (heat shock 70kDa protein 1A) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | ||
| HSPA2 (heat shock 70kDa protein 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of HSPA2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| HSPA8 (heat shock 70kDa protein 8) | Male and Female | 26 | 106 | Brain | -7.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1) | Using a linear mixed model, differential expression with age was identified in HSPBAP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HTATSF1 (HIV-1 Tat specific factor 1) | Using a linear mixed model, differential expression with age was identified in HTATSF1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled) | Using a linear mixed model, differential expression with age was identified in HTR2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of HTR7 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| HTRA1 (HtrA serine peptidase 1) | Using a linear mixed model, differential expression with age was identified in HTRA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Htra1 (HtrA serine peptidase 1) | Male and Female | 2 | 15 | Hippocampus | 2.0 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | ||
| HTRA1 (HtrA serine peptidase 1) | Male and Female | 26 | 106 | Brain | 7.0 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | ||
| HYAL1 (hyaluronoglucosaminidase 1) | Using a linear mixed model, differential expression with age was identified in HYAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| HYOU1 (hypoxia up-regulated 1) | Using a linear mixed model, differential expression with age was identified in HYOU1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| hypothetical gene supported by BC015790; BC041634 | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396) | |
| hypothetical LOC100126583 | Male and Female | 27 | 92 | Kidney | 43.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| hypothetical LOC144438 | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| hypothetical LOC202781 | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| hypothetical LOC440993 | Male and Female | 20 | 75 | Skeletal Muscle | 10.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| hypothetical protein DKFZp586I1420 | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| hypothetical protein LOC157860 | Male and Female | 20 | 75 | Skeletal Muscle | -15.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| hypothetical protein LOC284214 | Male and Female | 27 | 92 | Kidney | 53.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| hypothetical protein LOC552889 | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| IAH1 (isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ICA1 (islet cell autoantigen 1, 69kDa) | Using a linear mixed model, differential expression with age was identified in ICA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ICAM2 (intercellular adhesion molecule 2) | Using a linear mixed model, differential expression with age was identified in ICAM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ICAM3 (intercellular adhesion molecule 3) | Using a linear mixed model, differential expression with age was identified in ICAM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ICMT (isoprenylcysteine carboxyl methyltransferase) | Using a linear mixed model, differential expression with age was identified in ICMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Icmt (isoprenylcysteine carboxyl methyltransferase) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| IDS (iduronate 2-sulfatase) | Using a linear mixed model, differential expression with age was identified in IDS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IER3 (immediate early response 3) | Using a linear mixed model, differential expression with age was identified in IER3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ifi205 (interferon activated gene 205) | Male and Female | 3 | 23 | Hematological System | -3.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| IFI35 (interferon-induced protein 35) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of IFI35 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Ifi35 (interferon-induced protein 35) | Male and Female | 8 | 24 | Muscle | -10.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Igdcc3 (immunoglobulin superfamily, DCC subclass, member 3) | Male and Female | 6 | 22 | Liver | -5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of IGF2BP1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| IGFBP4 (insulin-like growth factor binding protein 4) | Using a linear mixed model, differential expression with age was identified in IGFBP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IGFBP5 (insulin-like growth factor binding protein 5) | Using a linear mixed model, differential expression with age was identified in IGFBP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IGFBP6 (insulin-like growth factor binding protein 6) | Using a linear mixed model, differential expression with age was identified in IGFBP6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IGFBP6 (insulin-like growth factor binding protein 6) | Using a linear mixed model, differential expression with age was identified in IGFBP6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IGFN1 (immunoglobulin-like and fibronectin type III domain containing 1) | Male and Female | 20 | 75 | Skeletal Muscle | -15.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| IGJ (immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides) | Male and Female | 27 | 92 | Kidney | 60.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Igj (immunoglobulin joining chain) | Male and Female | 5 | 22 | Brain | 51.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Igj (immunoglobulin joining chain) | Male and Female | 6 | 22 | Liver | 14.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| IGKV1-5 (immunoglobulin kappa variable 1-5) | Male and Female | 27 | 92 | Kidney | 35.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| IGLV3-25 (immunoglobulin lambda variable 3-25) | Male and Female | 27 | 92 | Kidney | 46.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| IGLV4-3 (immunoglobulin lambda variable 4-3) | Male and Female | 27 | 92 | Kidney | 41.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| IGSF9 (immunoglobulin superfamily, member 9) | Using a linear mixed model, differential expression with age was identified in IGSF9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) | Using a linear mixed model, differential expression with age was identified in IKBKB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IL11RA (interleukin 11 receptor, alpha) | Using a linear mixed model, differential expression with age was identified in IL11RA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IL18 (interleukin 18 (interferon-gamma-inducing factor)) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus IL18 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 68.88 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| IL18 (interleukin 18 (interferon-gamma-inducing factor)) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe IL18 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 56.68 | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) | |
| Il18rap (interleukin 18 receptor accessory protein) | Male and Female | 5 | 25 | Skeletal Muscle | -14.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| IL1B (interleukin 1, beta) | Using a linear mixed model, differential expression with age was identified in IL1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IL20RA (interleukin 20 receptor, alpha) | Using a linear mixed model, differential expression with age was identified in IL20RA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IL20RB (interleukin 20 receptor beta) | Using a linear mixed model, differential expression with age was identified in IL20RB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Il22ra2 (interleukin 22 receptor, alpha 2) | Male and Female | 2 | 26 | Lung | -14.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| IL32 (interleukin 32) | Using a linear mixed model, differential expression with age was identified in IL32 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IL33 (interleukin 33) | Male and Female | 26 | 106 | Brain | 47.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| IL34 (interleukin 34) | Comparison of DNA methylation showed a significantly decreased methylation level of IL34 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -27.7 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| IL34 (interleukin 34) | Comparison of DNA methylation showed a significantly decreased methylation level of IL34 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.6 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ILF3 (interleukin enhancer binding factor 3, 90kDa) | Using a linear mixed model, differential expression with age was identified in ILF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IMPA2 (inositol(myo)-1(or 4)-monophosphatase 2) | Using a linear mixed model, differential expression with age was identified in IMPA2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Impdh2 (inosine 5'-phosphate dehydrogenase 2) | Male and Female | 6 | 22 | Liver | 6.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Ing2 (inhibitor of growth family, member 2) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Ing4 (inhibitor of growth family, member 4) | Male and Female | 8 | 24 | Muscle | -8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Inha (inhibin alpha) | Male and Female | 5 | 30 | Anatomical System | -5.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| INHBB (inhibin, beta B) | Male and Female | 26 | 106 | Brain | 17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Inmt (indolethylamine N-methyltransferase) | Male and Female | 4 | 15 | Cochlea | -6.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| INO80D (INO80 complex subunit D) | Using a linear mixed model, differential expression with age was identified in INO80D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| INSIG1 (insulin induced gene 1) | Using a linear mixed model, differential expression with age was identified in INSIG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| INSR (insulin receptor) | Male and Female | 26 | 106 | Brain | 8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| INTU (inturned planar cell polarity protein) | Using a linear mixed model, differential expression with age was identified in INTU in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IP6K3 (inositol hexakisphosphate kinase 3) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| IPO8 (importin 8) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of IPO8 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| IQCB1 (IQ motif containing B1) | Using a linear mixed model, differential expression with age was identified in IQCB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IQCD (IQ motif containing D) | Gene expression showed a significant (p<E-3) increase in the expression of IQCD in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 56.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| Iqcf1 (IQ motif containing F1) | Male and Female | 5 | 22 | Brain | -98.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| IRAK2 (interleukin-1 receptor-associated kinase 2) | Using a linear mixed model, differential expression with age was identified in IRAK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IREB2 (iron-responsive element binding protein 2) | Male and Female | 26 | 106 | Brain | -25.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| IRF8 (interferon regulatory factor 8) | Using a linear mixed model, differential expression with age was identified in IRF8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IRS1 (insulin receptor substrate 1) | Using a linear mixed model, differential expression with age was identified in IRS1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IRS1 (insulin receptor substrate 1) | Using a linear mixed model, differential expression with age was identified in IRS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Irs1 (insulin receptor substrate 1) | Male and Female | 2 | 26 | Lung | -7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Irx2 (Iroquois related homeobox 2 (Drosophila)) | Male and Female | 2 | 26 | Lung | -8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| IRX6 (iroquois homeobox 6) | Using a linear mixed model, differential expression with age was identified in IRX6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Isca1 (iron-sulfur cluster assembly 1 homolog (S. cerevisiae)) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ISG20 (interferon stimulated exonuclease gene 20kDa) | Using a linear mixed model, differential expression with age was identified in ISG20 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ISL1 (ISL LIM homeobox 1) | Using a linear mixed model, differential expression with age was identified in ISL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)) | Using a linear mixed model, differential expression with age was identified in ITGA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ITGA2B and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ITGAM (integrin, alpha M (complement component 3 receptor 3 subunit)) | Using a linear mixed model, differential expression with age was identified in ITGAM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Itgb2 (integrin beta 2) | Male and Female | 2 | 24 | Visual Apparatus | 306.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| ITGB4 (integrin, beta 4) | Using a linear mixed model, differential expression with age was identified in ITGB4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Itgb5 (integrin beta 5) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Itm2a (integral membrane protein 2A) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| ITPKA (inositol 1,4,5-trisphosphate 3-kinase A) | Male and Female | 26 | 106 | Brain | -24.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ITPKB (inositol 1,4,5-trisphosphate 3-kinase B) | Male and Female | 26 | 106 | Brain | 15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ITPR3 (inositol 1,4,5-trisphosphate receptor, type 3) | Using a linear mixed model, differential expression with age was identified in ITPR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| IVD (isovaleryl-CoA dehydrogenase) | Using a linear mixed model, differential expression with age was identified in IVD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| JAG2 (jagged 2) | Using a linear mixed model, differential expression with age was identified in JAG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| JAKMIP3 (Janus kinase and microtubule interacting protein 3) | Gene expression showed a significant (p<E-3) increase in the expression of JAKMIP3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 100.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| JAM2 (junctional adhesion molecule 2) | Using a linear mixed model, differential expression with age was identified in JAM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| JOSD2 (Josephin domain containing 2) | Using a linear mixed model, differential expression with age was identified in JOSD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| JPH1 (junctophilin 1) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| JUND (jun D proto-oncogene) | Using a linear mixed model, differential expression with age was identified in JUND in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KANK1 (KN motif and ankyrin repeat domains 1) | Male and Female | 26 | 106 | Brain | 16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KANSL1 (KAT8 regulatory NSL complex subunit 1) | Using a linear mixed model, differential expression with age was identified in KANSL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KANSL3 (KAT8 regulatory NSL complex subunit 3) | Using a linear mixed model, differential expression with age was identified in KANSL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KAT2A (K(lysine) acetyltransferase 2A) | Using a linear mixed model, differential expression with age was identified in KAT2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KAZALD1 (Kazal-type serine peptidase inhibitor domain 1) | Using a linear mixed model, differential expression with age was identified in KAZALD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KBTBD11 (kelch repeat and BTB (POZ) domain containing 11) | Using a linear mixed model, differential expression with age was identified in KBTBD11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Kcnab1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| KCNAB3 (potassium voltage-gated channel, shaker-related subfamily, beta member 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of KCNAB3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| KCNG2 (potassium voltage-gated channel, subfamily G, member 2) | Male and Female | 20 | 75 | Skeletal Muscle | -10.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| KCNG3 (potassium voltage-gated channel, subfamily G, member 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of KCNG3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| KCNIP4 (Kv channel interacting protein 4) | Using a linear mixed model, differential expression with age was identified in KCNIP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCNJ2 (potassium inwardly-rectifying channel, subfamily J, member 2) | Using a linear mixed model, differential expression with age was identified in KCNJ2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCNJ8 (potassium inwardly-rectifying channel, subfamily J, member 8) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of KCNJ8 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| KCNJ9 (potassium inwardly-rectifying channel, subfamily J, member 9) | Male and Female | 26 | 106 | Brain | -27.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KCNK12 (potassium channel, subfamily K, member 12) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of KCNK12 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| KCNK2 (potassium channel, subfamily K, member 2) | Using a linear mixed model, differential expression with age was identified in KCNK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCNMB1 (potassium large conductance calcium-activated channel, subfamily M, beta member 1) | Using a linear mixed model, differential expression with age was identified in KCNMB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCNS1 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1) | Using a linear mixed model, differential expression with age was identified in KCNS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCTD13 (potassium channel tetramerization domain containing 13) | Using a linear mixed model, differential expression with age was identified in KCTD13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KCTD15 (potassium channel tetramerization domain containing 15) | Using a linear mixed model, differential expression with age was identified in KCTD15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Kctd3 (potassium channel tetramerisation domain containing 3) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Kdelr1 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1) | Male and Female | 6 | 22 | Liver | 2.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| KDELR3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3) | Using a linear mixed model, differential expression with age was identified in KDELR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Kdr (kinase insert domain protein receptor) | Male and Female | 3 | 23 | Hematological System | 28.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| KHDRBS3 (KH domain containing, RNA binding, signal transduction associated 3) | Using a linear mixed model, differential expression with age was identified in KHDRBS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0226L (KIAA0226-like) | Using a linear mixed model, differential expression with age was identified in KIAA0226L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0232 (KIAA0232) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| KIAA0317 (KIAA0317) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KIAA0319 (KIAA0319) | Using a linear mixed model, differential expression with age was identified in KIAA0319 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0430 (KIAA0430) | Using a linear mixed model, differential expression with age was identified in KIAA0430 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0513 (KIAA0513) | Using a linear mixed model, differential expression with age was identified in KIAA0513 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0586 (KIAA0586) | Using a linear mixed model, differential expression with age was identified in KIAA0586 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0753 (KIAA0753) | Using a linear mixed model, differential expression with age was identified in KIAA0753 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA0907 (KIAA0907) | Using a linear mixed model, differential expression with age was identified in KIAA0907 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA1407 (KIAA1407) | Using a linear mixed model, differential expression with age was identified in KIAA1407 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA1430 (KIAA1430) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| KIAA1467 (KIAA1467) | Using a linear mixed model, differential expression with age was identified in KIAA1467 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA1467 (KIAA1467) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KIAA1468 (KIAA1468) | Using a linear mixed model, differential expression with age was identified in KIAA1468 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIAA1551 (KIAA1551) | Gene expression showed a significant (p<E-3) increase in the expression of KIAA1551 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 71.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| KIAA1737 (KIAA1737) | Gene expression showed a significant (p<E-3) decrease in the expression of KIAA1737 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -50.25 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| KIF19 (kinesin family member 19) | Using a linear mixed model, differential expression with age was identified in KIF19 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIF1B (kinesin family member 1B) | Using a linear mixed model, differential expression with age was identified in KIF1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KIF1B (kinesin family member 1B) | Gene expression showed a significant (p<E-3) decrease in the expression of KIF1B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -43.18 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| Kif2a (kinesin family member 2A) | Male and Female | 2 | 26 | Lung | 6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| KIF3C (kinesin family member 3C) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Kif6 (kinesin family member 6) | Male and Female | 3 | 23 | Hematological System | 33.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| KLF13 (Kruppel-like factor 13) | Male and Female | 20 | 75 | Skeletal Muscle | 8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| KLHDC3 (kelch domain containing 3) | Using a linear mixed model, differential expression with age was identified in KLHDC3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KLHDC3 (kelch domain containing 3) | Male and Female | 26 | 106 | Brain | -26.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KLHDC8B (kelch domain containing 8B) | Using a linear mixed model, differential expression with age was identified in KLHDC8B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KLHL29 (kelch-like family member 29) | Using a linear mixed model, differential expression with age was identified in KLHL29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KLHL3 (kelch-like 3 (Drosophila)) | Male and Female | 27 | 92 | Kidney | -14.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| KLHL31 (kelch-like 31 (Drosophila)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| KLHL9 (kelch-like 9 (Drosophila)) | Male and Female | 26 | 106 | Brain | 6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| KLK12 (kallikrein-related peptidase 12) | Using a linear mixed model, differential expression with age was identified in KLK12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Klk1b5 (kallikrein 1-related peptidase b5) | Male and Female | 2 | 26 | Lung | -36.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Klk6 (kallikrein related-peptidase 6) | Male and Female | 5 | 30 | Anatomical System | 68.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| KLK6 (kallikrein-related peptidase 6) | Using a linear mixed model, differential expression with age was identified in KLK6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Klra19 (killer cell lectin-like receptor, subfamily A, member 19) | Male and Female | 5 | 22 | Brain | -97.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Klraq1 (KLRAQ motif containing 1) | Male and Female | 6 | 22 | Liver | 2.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| KLRB1 (killer cell lectin-like receptor subfamily B, member 1) | Using a linear mixed model, differential expression with age was identified in KLRB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KNG1 (kininogen 1) | Male and Female | 27 | 92 | Kidney | -17.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Kpna2 (karyopherin (importin) alpha 2) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| KPNA6 (karyopherin alpha 6 (importin alpha 7)) | Using a linear mixed model, differential expression with age was identified in KPNA6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRI1 (KRI1 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in KRI1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT15 (keratin 15) | Using a linear mixed model, differential expression with age was identified in KRT15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Krt15 (keratin 15) | Male and Female | 6 | 22 | Liver | -26.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| KRT16 (keratin 16) | Using a linear mixed model, differential expression with age was identified in KRT16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT25 (keratin 25) | Using a linear mixed model, differential expression with age was identified in KRT25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT27 (keratin 27) | Using a linear mixed model, differential expression with age was identified in KRT27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT32 (keratin 32) | Using a linear mixed model, differential expression with age was identified in KRT32 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT33B (keratin 33B) | Using a linear mixed model, differential expression with age was identified in KRT33B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT34 (keratin 34) | Using a linear mixed model, differential expression with age was identified in KRT34 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT35 (keratin 35) | Using a linear mixed model, differential expression with age was identified in KRT35 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT38 (keratin 38) | Using a linear mixed model, differential expression with age was identified in KRT38 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT4 (keratin 4) | Using a linear mixed model, differential expression with age was identified in KRT4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT5 (keratin 5) | Using a linear mixed model, differential expression with age was identified in KRT5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT6A (keratin 6A) | Using a linear mixed model, differential expression with age was identified in KRT6A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT6A (keratin 6A) | Comparison of DNA methylation showed a significantly decreased methylation level of KRT6A in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.7 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| KRT6B (keratin 6B) | Using a linear mixed model, differential expression with age was identified in KRT6B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT71 (keratin 71) | Using a linear mixed model, differential expression with age was identified in KRT71 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT74 (keratin 74) | Using a linear mixed model, differential expression with age was identified in KRT74 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT75 (keratin 75) | Using a linear mixed model, differential expression with age was identified in KRT75 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT79 (keratin 79) | Using a linear mixed model, differential expression with age was identified in KRT79 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT81 (keratin 81) | Using a linear mixed model, differential expression with age was identified in KRT81 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT85 (keratin 85) | Using a linear mixed model, differential expression with age was identified in KRT85 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT86 (keratin 86) | Using a linear mixed model, differential expression with age was identified in KRT86 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRT9 (keratin 9) | Using a linear mixed model, differential expression with age was identified in KRT9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP10-1 (keratin associated protein 10-1) | Using a linear mixed model, differential expression with age was identified in KRTAP10-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP10-2 (keratin associated protein 10-2) | Using a linear mixed model, differential expression with age was identified in KRTAP10-2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP10-4 (keratin associated protein 10-4) | Using a linear mixed model, differential expression with age was identified in KRTAP10-4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP10-9 (keratin associated protein 10-9) | Using a linear mixed model, differential expression with age was identified in KRTAP10-9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP11-1 (keratin associated protein 11-1) | Using a linear mixed model, differential expression with age was identified in KRTAP11-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP12-1 (keratin associated protein 12-1) | Using a linear mixed model, differential expression with age was identified in KRTAP12-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP12-2 (keratin associated protein 12-2) | Using a linear mixed model, differential expression with age was identified in KRTAP12-2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP17-1 (keratin associated protein 17-1) | Using a linear mixed model, differential expression with age was identified in KRTAP17-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP19-1 (keratin associated protein 19-1) | Using a linear mixed model, differential expression with age was identified in KRTAP19-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP24-1 (keratin associated protein 24-1) | Using a linear mixed model, differential expression with age was identified in KRTAP24-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP26-1 (keratin associated protein 26-1) | Using a linear mixed model, differential expression with age was identified in KRTAP26-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP4-1 (keratin associated protein 4-1) | Using a linear mixed model, differential expression with age was identified in KRTAP4-1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP4-2 (keratin associated protein 4-2) | Using a linear mixed model, differential expression with age was identified in KRTAP4-2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP4-3 (keratin associated protein 4-3) | Using a linear mixed model, differential expression with age was identified in KRTAP4-3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP4-4 (keratin associated protein 4-4) | Using a linear mixed model, differential expression with age was identified in KRTAP4-4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP4-5 (keratin associated protein 4-5) | Using a linear mixed model, differential expression with age was identified in KRTAP4-5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP5-2 (keratin associated protein 5-2) | Using a linear mixed model, differential expression with age was identified in KRTAP5-2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP5-5 (keratin associated protein 5-5) | Using a linear mixed model, differential expression with age was identified in KRTAP5-5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP5-7 (keratin associated protein 5-7) | Using a linear mixed model, differential expression with age was identified in KRTAP5-7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP9-3 (keratin associated protein 9-3) | Using a linear mixed model, differential expression with age was identified in KRTAP9-3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP9-4 (keratin associated protein 9-4) | Using a linear mixed model, differential expression with age was identified in KRTAP9-4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP9-8 (keratin associated protein 9-8) | Using a linear mixed model, differential expression with age was identified in KRTAP9-8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| KRTAP9-9 (keratin associated protein 9-9) | Using a linear mixed model, differential expression with age was identified in KRTAP9-9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| L1cam (L1 cell adhesion molecule) | Male and Female | 5 | 30 | Anatomical System | -12.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| LAD1 (ladinin 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of LAD1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| LAG3 (lymphocyte-activation gene 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of LAG3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| LAG3 (lymphocyte-activation gene 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of LAG3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| LAMA3 (laminin, alpha 3) | Using a linear mixed model, differential expression with age was identified in LAMA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAMA5 (laminin, alpha 5) | Using a linear mixed model, differential expression with age was identified in LAMA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAMB1 (laminin, beta 1) | Using a linear mixed model, differential expression with age was identified in LAMB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lamb1-1 (laminin B1 subunit 1) | Male and Female | 8 | 24 | Muscle | -8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| LAMB3 (laminin, beta 3) | Using a linear mixed model, differential expression with age was identified in LAMB3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAMB4 (laminin, beta 4) | Using a linear mixed model, differential expression with age was identified in LAMB4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lamp1 (lysosomal-associated membrane protein 1) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Lamp1 (lysosomal-associated membrane protein 1) | Male and Female | 5 | 22 | Brain | 2.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| LAMP2 (lysosomal-associated membrane protein 2) | Using a linear mixed model, differential expression with age was identified in LAMP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAMP2 (lysosomal-associated membrane protein 2) | Male and Female | 26 | 106 | Brain | 21.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1) | Using a linear mixed model, differential expression with age was identified in LAMTOR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) | Using a linear mixed model, differential expression with age was identified in LAMTOR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LAPTM5 (lysosomal protein transmembrane 5) | Using a linear mixed model, differential expression with age was identified in LAPTM5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lat (linker for activation of T cells) | Male and Female | 2 | 26 | Lung | 18.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| LCAT (lecithin-cholesterol acyltransferase) | Using a linear mixed model, differential expression with age was identified in LCAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LCAT (lecithin-cholesterol acyltransferase) | Comparison of DNA methylation showed a significantly decreased methylation level of LCAT in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -18.6 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| LDHD (lactate dehydrogenase D) | Using a linear mixed model, differential expression with age was identified in LDHD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LDLRAD3 (low density lipoprotein receptor class A domain containing 3) | Gene expression showed a significant (p<E-3) increase in the expression of LDLRAD3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 60.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| LEAP2 (liver expressed antimicrobial peptide 2) | Using a linear mixed model, differential expression with age was identified in LEAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LEF1 (lymphoid enhancer-binding factor 1) | Using a linear mixed model, differential expression with age was identified in LEF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LENG8 (leukocyte receptor cluster (LRC) member 8) | Using a linear mixed model, differential expression with age was identified in LENG8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LEPR (leptin receptor) | Using a linear mixed model, differential expression with age was identified in LEPR in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LEPRE1 (leucine proline-enriched proteoglycan (leprecan) 1) | Using a linear mixed model, differential expression with age was identified in LEPRE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LEPREL1 (leprecan-like 1) | Using a linear mixed model, differential expression with age was identified in LEPREL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LEPREL2 (leprecan-like 2) | Using a linear mixed model, differential expression with age was identified in LEPREL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) | Using a linear mixed model, differential expression with age was identified in LFNG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LGALS1 (lectin, galactoside-binding, soluble, 1) | Using a linear mixed model, differential expression with age was identified in LGALS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lgals3 (lectin, galactose binding, soluble 3) | Male and Female | 2 | 24 | Visual Apparatus | 141.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| LGALS3BP (lectin, galactoside-binding, soluble, 3 binding protein) | Using a linear mixed model, differential expression with age was identified in LGALS3BP in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LGALS8 (lectin, galactoside-binding, soluble, 8) | Using a linear mixed model, differential expression with age was identified in LGALS8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LGI3 (leucine-rich repeat LGI family, member 3) | Using a linear mixed model, differential expression with age was identified in LGI3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LGMN (legumain) | Using a linear mixed model, differential expression with age was identified in LGMN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LGMN (legumain) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| LHCGR (luteinizing hormone/choriogonadotropin receptor) | Using a linear mixed model, differential expression with age was identified in LHCGR in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LHX5 (LIM homeobox 5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of LHX5 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| LIF (leukemia inhibitory factor) | Using a linear mixed model, differential expression with age was identified in LIF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LIG1 (ligase I, DNA, ATP-dependent) | Using a linear mixed model, differential expression with age was identified in LIG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LIMCH1 (LIM and calponin homology domains 1) | Using a linear mixed model, differential expression with age was identified in LIMCH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LINC00467 (long intergenic non-protein coding RNA 467) | Using a linear mixed model, differential expression with age was identified in LINC00467 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LINC00479 (long intergenic non-protein coding RNA 479) | Using a linear mixed model, differential expression with age was identified in LINC00479 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LIPG (lipase, endothelial) | Using a linear mixed model, differential expression with age was identified in LIPG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LLGL2 (lethal giant larvae homolog 2 (Drosophila)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of LLGL2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Lman1 (lectin, mannose-binding, 1) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| LMO3 (LIM domain only 3 (rhombotin-like 2)) | Using a linear mixed model, differential expression with age was identified in LMO3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LMO3 (LIM domain only 3 (rhombotin-like 2)) | Using a linear mixed model, differential expression with age was identified in LMO3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LMTK2 (lemur tyrosine kinase 2) | Male and Female | 20 | 75 | Skeletal Muscle | 15.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| LMX1A (LIM homeobox transcription factor 1, alpha) | Using a linear mixed model, differential expression with age was identified in LMX1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lnx1 (ligand of numb-protein X 1) | Male and Female | 5 | 30 | Anatomical System | -4.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| LOC380889 (LOC380889) | Male and Female | 5 | 22 | Brain | -80.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| LOC641050 (LOC641050) | Male and Female | 2 | 26 | Lung | 30.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| LOC67527 (LOC67527) | Male and Female | 2 | 26 | Lung | 20.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| LOC728592 (similar to hCG2020539) | Gene expression showed a significant (p<E-3) decrease in the expression of LOC728592 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -56.14 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| LOX (lysyl oxidase) | Using a linear mixed model, differential expression with age was identified in LOX in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LOXL4 (lysyl oxidase-like 4) | Using a linear mixed model, differential expression with age was identified in LOXL4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Loxl4 (lysyl oxidase-like 4) | Male and Female | 5 | 22 | Brain | -48.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| LPCAT3 (lysophosphatidylcholine acyltransferase 3) | Using a linear mixed model, differential expression with age was identified in LPCAT3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LPIN1 (lipin 1) | Male and Female | 22 | 73 | Skeletal Muscle | -5.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| Lpin1 (lipin 1) | Male and Female | 2 | 15 | Hippocampus | 5.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| LPL (lipoprotein lipase) | Male and Female | 27 | 92 | Kidney | -17.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| LPPR4 (lipid phosphate phosphatase-related protein type 4) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| LPXN (leupaxin) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of LPXN and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| LRG1 (leucine-rich alpha-2-glycoprotein 1) | Using a linear mixed model, differential expression with age was identified in LRG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRIG1 (leucine-rich repeats and immunoglobulin-like domains 1) | Male and Female | 26 | 106 | Brain | 13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| LRIG3 (leucine-rich repeats and immunoglobulin-like domains 3) | Using a linear mixed model, differential expression with age was identified in LRIG3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRP3 (low density lipoprotein receptor-related protein 3) | Using a linear mixed model, differential expression with age was identified in LRP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRP4 (low density lipoprotein receptor-related protein 4) | Using a linear mixed model, differential expression with age was identified in LRP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRP5L (low density lipoprotein receptor-related protein 5-like) | Using a linear mixed model, differential expression with age was identified in LRP5L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRRC15 (leucine rich repeat containing 15) | Using a linear mixed model, differential expression with age was identified in LRRC15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRRC17 (leucine rich repeat containing 17) | Using a linear mixed model, differential expression with age was identified in LRRC17 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LRRC18 (leucine rich repeat containing 18) | Using a linear mixed model, differential expression with age was identified in LRRC18 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Lrrc28 (leucine rich repeat containing 28) | Male and Female | 2 | 26 | Lung | 2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Lrrc63 (leucine rich repeat containing 63) | Male and Female | 5 | 22 | Brain | -87.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Lrrc69 (leucine rich repeat containing 69) | Male and Female | 5 | 22 | Brain | 197.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| LRRN4CL (LRRN4 C-terminal like) | Using a linear mixed model, differential expression with age was identified in LRRN4CL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LSAMP (limbic system-associated membrane protein) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of LSAMP and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| LSM1 (LSM1, U6 small nuclear RNA associated) | Using a linear mixed model, differential expression with age was identified in LSM1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LSM4 (LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in LSM4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LSM5 (LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)) | Gene expression showed a significant (p<E-3) decrease in the expression of LSM5 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -66.33 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| LSS (lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)) | Using a linear mixed model, differential expression with age was identified in LSS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LTB (lymphotoxin beta (TNF superfamily, member 3)) | Using a linear mixed model, differential expression with age was identified in LTB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LTB4R (leukotriene B4 receptor) | Using a linear mixed model, differential expression with age was identified in LTB4R in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LTBP1 (latent transforming growth factor beta binding protein 1) | Male and Female | 26 | 106 | Brain | 19.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Ltbp3 (latent transforming growth factor beta binding protein 3) | Male and Female | 2 | 26 | Lung | -9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| LTF (lactotransferrin) | Male and Female | 27 | 92 | Kidney | 115.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Ltf (lactotransferrin) | Male and Female | 2 | 15 | Hippocampus | 23.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| LUC7L3 (LUC7-like 3 (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in LUC7L3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LUC7L3 (LUC7-like 3 (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ly6a (lymphocyte antigen 6 complex, locus A) | Male and Female | 6 | 22 | Liver | 17.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| LY6E (lymphocyte antigen 6 complex, locus E) | Using a linear mixed model, differential expression with age was identified in LY6E in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LY6G6D (lymphocyte antigen 6 complex, locus G6D) | Using a linear mixed model, differential expression with age was identified in LY6G6D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LY86 (lymphocyte antigen 86) | Using a linear mixed model, differential expression with age was identified in LY86 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ly86 (lymphocyte antigen 86) | Male and Female | 2 | 15 | Hippocampus | 8.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| LYG2 (lysozyme G-like 2) | Using a linear mixed model, differential expression with age was identified in LYG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LYPD6 (LY6/PLAUR domain containing 6) | Using a linear mixed model, differential expression with age was identified in LYPD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LYSMD4 (LysM, putative peptidoglycan-binding, domain containing 4) | Using a linear mixed model, differential expression with age was identified in LYSMD4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1) | Using a linear mixed model, differential expression with age was identified in LYVE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| LYZ (lysozyme (renal amyloidosis)) | Male and Female | 27 | 92 | Kidney | 57.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Lyz1 (lysozyme 1) | Male and Female | 5 | 30 | Anatomical System | 82.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Lyz1 (lysozyme 1) | Male and Female | 2 | 24 | Visual Apparatus | 82.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| LZTS1 (leucine zipper, putative tumor suppressor 1) | Using a linear mixed model, differential expression with age was identified in LZTS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAATS1 (MYCBP-associated, testis expressed 1) | Using a linear mixed model, differential expression with age was identified in MAATS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAD1L1 (MAD1 mitotic arrest deficient-like 1 (yeast)) | Using a linear mixed model, differential expression with age was identified in MAD1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAD2L1BP (MAD2L1 binding protein) | Gene expression showed a significant (p<E-3) increase in the expression of MAD2L1BP in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 58.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| MAGED1 (melanoma antigen family D, 1) | Using a linear mixed model, differential expression with age was identified in MAGED1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAGED2 (melanoma antigen family D, 2) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Maged2 (melanoma antigen, family D, 2) | Male and Female | 5 | 25 | Skeletal Muscle | 2.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| MAGEE1 (melanoma antigen family E, 1) | Using a linear mixed model, differential expression with age was identified in MAGEE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mal (myelin and lymphocyte protein, T-cell differentiation protein) | Male and Female | 5 | 30 | Anatomical System | 3.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1) | Using a linear mixed model, differential expression with age was identified in MALT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAMDC2 (MAM domain containing 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of MAMDC2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Mamdc2 (MAM domain containing 2) | Male and Female | 3 | 23 | Hematological System | -7.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| MAMDC4 (MAM domain containing 4) | Using a linear mixed model, differential expression with age was identified in MAMDC4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MANF (mesencephalic astrocyte-derived neurotrophic factor) | Using a linear mixed model, differential expression with age was identified in MANF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAP1A (microtubule-associated protein 1A) | Using a linear mixed model, differential expression with age was identified in MAP1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAP2 (microtubule-associated protein 2) | Male and Female | 26 | 106 | Brain | -20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MAP2K1 (mitogen-activated protein kinase kinase 1) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Map2k2 (mitogen-activated protein kinase kinase 2) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Map2k6 (mitogen-activated protein kinase kinase 6) | Male and Female | 8 | 24 | Muscle | -8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MAP3K15 (mitogen-activated protein kinase kinase kinase 15) | Male and Female | 20 | 75 | Skeletal Muscle | -8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MAP3K5 (mitogen-activated protein kinase kinase kinase 5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MAP3K5 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MAP3K5 (mitogen-activated protein kinase kinase kinase 5) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of MAP3K5 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| MAP3K6 (mitogen-activated protein kinase kinase kinase 6) | Using a linear mixed model, differential expression with age was identified in MAP3K6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAP3K7 (mitogen-activated protein kinase kinase kinase 7) | Using a linear mixed model, differential expression with age was identified in MAP3K7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAP3K7CL (MAP3K7 C-terminal like) | Using a linear mixed model, differential expression with age was identified in MAP3K7CL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Map3k9 (mitogen-activated protein kinase kinase kinase 9) | Male and Female | 3 | 23 | Hematological System | 16.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Map4k2 (mitogen-activated protein kinase kinase kinase kinase 2) | Male and Female | 5 | 30 | Anatomical System | -19.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) | Gene expression showed a significant (p<E-3) increase in the expression of MAP4K4 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 69.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| MAPK1 (mitogen-activated protein kinase 1) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MAPK3 (mitogen-activated protein kinase 3) | Using a linear mixed model, differential expression with age was identified in MAPK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPK6 (mitogen-activated protein kinase 6) | Male and Female | 22 | 73 | Skeletal Muscle | -4.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2) | Using a linear mixed model, differential expression with age was identified in MAPK8IP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3) | Using a linear mixed model, differential expression with age was identified in MAPK8IP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPK9 (mitogen-activated protein kinase 9) | Male and Female | 26 | 106 | Brain | -15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MAPKAP1 (mitogen-activated protein kinase associated protein 1) | Using a linear mixed model, differential expression with age was identified in MAPKAP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPKAPK5-AS1 (MAPKAPK5 antisense RNA 1) | Using a linear mixed model, differential expression with age was identified in MAPKAPK5-AS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPKBP1 (mitogen-activated protein kinase binding protein 1) | Using a linear mixed model, differential expression with age was identified in MAPKBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAPRE2 (microtubule-associated protein, RP/EB family, member 2) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MAPT (microtubule-associated protein tau) | Male and Female | 26 | 106 | Brain | -14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| March7 (membrane-associated ring finger (C3HC4) 7) | Male and Female | 2 | 26 | Lung | 4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| March7 (membrane-associated ring finger (C3HC4) 7) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MARCKSL1 (MARCKS-like 1) | Using a linear mixed model, differential expression with age was identified in MARCKSL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MARK1 (MAP/microtubule affinity-regulating kinase 1) | Using a linear mixed model, differential expression with age was identified in MARK1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MASP1 (mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)) | Using a linear mixed model, differential expression with age was identified in MASP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MASP2 (mannan-binding lectin serine peptidase 2) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MAST4 (microtubule associated serine/threonine kinase family member 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MAST4 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MATN2 (matrilin 2) | Using a linear mixed model, differential expression with age was identified in MATN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAU2 (MAU2 sister chromatid cohesion factor) | Using a linear mixed model, differential expression with age was identified in MAU2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MAX (MYC associated factor X) | Using a linear mixed model, differential expression with age was identified in MAX in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mbd2 (methyl-CpG binding domain protein 2) | Male and Female | 8 | 24 | Muscle | 5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MBD6 (methyl-CpG binding domain protein 6) | Using a linear mixed model, differential expression with age was identified in MBD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mbd6 (methyl-CpG binding domain protein 6) | Male and Female | 8 | 24 | Muscle | 6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Mbl2 (mannose-binding lectin (protein C) 2) | Male and Female | 6 | 22 | Liver | 4.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MBNL2 (muscleblind-like 2 (Drosophila)) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MBOAT1 (membrane bound O-acyltransferase domain containing 1) | Using a linear mixed model, differential expression with age was identified in MBOAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MBP (myelin basic protein) | Gene expression showed a significant (p<E-3) increase in the expression of MBP in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 139.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| MC5R (melanocortin 5 receptor) | Using a linear mixed model, differential expression with age was identified in MC5R in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MCAT (malonyl CoA:ACP acyltransferase (mitochondrial)) | Using a linear mixed model, differential expression with age was identified in MCAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mcfd2 (multiple coagulation factor deficiency 2) | Male and Female | 6 | 22 | Liver | 0.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MCM3AP (minichromosome maintenance complex component 3 associated protein) | Using a linear mixed model, differential expression with age was identified in MCM3AP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MCOLN2 (mucolipin 2) | Using a linear mixed model, differential expression with age was identified in MCOLN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MCUR1 (mitochondrial calcium uniporter regulator 1) | Using a linear mixed model, differential expression with age was identified in MCUR1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MDC1 (mediator of DNA-damage checkpoint 1) | Using a linear mixed model, differential expression with age was identified in MDC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MDH1 (malate dehydrogenase 1, NAD (soluble)) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MDH1 (malate dehydrogenase 1, NAD (soluble)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MDH2 (malate dehydrogenase 2, NAD (mitochondrial)) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Mdm4 (transformed mouse 3T3 cell double minute 4) | Male and Female | 5 | 25 | Skeletal Muscle | -25.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ME1 (malic enzyme 1, NADP(+)-dependent, cytosolic) | Using a linear mixed model, differential expression with age was identified in ME1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ME2 (malic enzyme 2, NAD(+)-dependent, mitochondrial) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ME3 (malic enzyme 3, NADP(+)-dependent, mitochondrial) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MEA1 (Male-enhanced antigen 1) | Using a linear mixed model, differential expression with age was identified in MEA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MECR (mitochondrial trans-2-enoyl-CoA reductase) | Using a linear mixed model, differential expression with age was identified in MECR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MEF2A (myocyte enhancer factor 2A) | Using a linear mixed model, differential expression with age was identified in MEF2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MEG3 (maternally expressed 3 (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in MEG3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MEGF8 (multiple EGF-like-domains 8) | Male and Female | 26 | 106 | Brain | -27.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MEIS1 (Meis homeobox 1) | Using a linear mixed model, differential expression with age was identified in MEIS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MEIS1 (Meis homeobox 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MEIS1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Meis2 (Meis homeobox 2) | Male and Female | 3 | 23 | Hematological System | 17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Meox1 (mesenchyme homeobox 1) | Male and Female | 2 | 26 | Lung | -19.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| MERTK (MER proto-oncogene, tyrosine kinase) | Using a linear mixed model, differential expression with age was identified in MERTK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mesdc2 (mesoderm development candidate 2) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| METTL17 (methyltransferase like 17) | Using a linear mixed model, differential expression with age was identified in METTL17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mettl2 (methyltransferase like 2) | Male and Female | 5 | 22 | Brain | -5.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| METTL2B (methyltransferase like 2B) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| METTL7B (methyltransferase like 7B) | Using a linear mixed model, differential expression with age was identified in METTL7B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MFAP3L (microfibrillar-associated protein 3-like) | Using a linear mixed model, differential expression with age was identified in MFAP3L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MFAP5 (microfibrillar associated protein 5) | Comparison of DNA methylation showed a significantly decreased methylation level of MFAP5 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -46.4 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| MFAP5 (microfibrillar associated protein 5) | Comparison of DNA methylation showed a significantly decreased methylation level of MFAP5 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.0 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| MFF (mitochondrial fission factor) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MFSD12 (major facilitator superfamily domain containing 12) | Using a linear mixed model, differential expression with age was identified in MFSD12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MFSD5 (major facilitator superfamily domain containing 5) | Using a linear mixed model, differential expression with age was identified in MFSD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mfsd7b (major facilitator superfamily domain containing 7B) | Male and Female | 3 | 23 | Hematological System | 5.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| MGAT1 (mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase) | Using a linear mixed model, differential expression with age was identified in MGAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MGEA5 (meningioma expressed antigen 5 (hyaluronidase)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MGEA5 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MGME1 (mitochondrial genome maintenance exonuclease 1) | Using a linear mixed model, differential expression with age was identified in MGME1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MGST1 (microsomal glutathione S-transferase 1) | Using a linear mixed model, differential expression with age was identified in MGST1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MIAT (myocardial infarction associated transcript (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in MIAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MICA (MHC class I polypeptide-related sequence A) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe MICA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 39.49 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MICA (MHC class I polypeptide-related sequence A) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe MICA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 37.9 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MICALL2 (MICAL-like 2) | Using a linear mixed model, differential expression with age was identified in MICALL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MICB (MHC class I polypeptide-related sequence B) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe MICB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 39.86 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| Miip (migration and invasion inhibitory protein) | Male and Female | 8 | 24 | Muscle | -6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MIPEP (mitochondrial intermediate peptidase) | Using a linear mixed model, differential expression with age was identified in MIPEP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MIPEP (mitochondrial intermediate peptidase) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MIR100 (microRNA 100) | Expression level of miR-100 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -49.12957126 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR101-1 (microRNA 101-1) | Expression level of miR-101 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -49.52890172 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR101-1 (microRNA 101-1) | Expression level of miR-101 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -29.60331458 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR103A1 (microRNA 103a-1) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-103 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR106A (microRNA 106a) | MicroRNA level showed a significant (p<E-4) decrease in the expression of miR-106a from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | -98.7 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR106B (microRNA 106b) | Expression level of miR-106b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -40.42070508 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR107 (microRNA 107) | Expression level of miR-107 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -29.66190219 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR107 (microRNA 107) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) individuals shows that miR-107 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR10A (microRNA 10a) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MIR10A and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MIR10A (microRNA 10a) | Expression level of miR-10a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -52.22402421 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR10B (microRNA 10b) | Expression level of miR-10b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -41.64350787 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR1248 (microRNA 1248) | MicroRNA level of miR-1248 showed a decrease in older individuals (mean age 64) when compared with younger controls (mean age 30) | Male and Female | 30 | 64 | Blood | 3453: Noren Hooten, N et al. (2013) "Age-related changes in microRNA levels in serum." Aging (Albany NY) 5(10):725-740 (24088671) | ||
| MIR125A (microRNA 125a) | Expression level of miR-125a-5p is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -48.17039516 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR125B1 (microRNA 125b-1) | Expression level of miR-125b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -30.47602874 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR126 (microRNA 126) | Expression level of miR-126 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -33.08045221 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR126 (microRNA 126) | Expression level of miR-126* is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -32.25540503 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR126 (microRNA 126) | MicroRNA level showed a significant (p<E-4) decrease in the expression of miR-126 from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | -93.3 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR128-1 (microRNA 128-1) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-128 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR128-2 (microRNA 128-2) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-128 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR130A (microRNA 130a) | Expression level of miR-130a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -44.56983319 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR130A (microRNA 130a) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-130a has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR144 (microRNA 144) | Expression level of miR-144 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 390.1654161 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR144 (microRNA 144) | MicroRNA level showed a significant (p<E-4) decrease in the expression of miR-144* from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | -85.9 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR146B (microRNA 146b) | Expression level of miR-146b-5p is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 59.35098471 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR148B (microRNA 148b) | Expression level of miR-148b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -31.81083997 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR149 (microRNA 149) | Expression level of miR-149 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -34.64544232 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR151A (microRNA 151a) | Expression level of miR-151-5p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -26.76799245 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR152 (microRNA 152) | Expression level of miR-152 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -35.1083559 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR1538 (microRNA 1538) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-1538 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR154 (microRNA 154) | Expression level of miR-154* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 67.71547678 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR155 (microRNA 155) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-155 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR15A (microRNA 15a) | Expression level of miR-15a is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -78.01472003 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR15B (microRNA 15b) | Expression level of miR-15b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -28.15990463 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR15B (microRNA 15b) | Expression level of miR-15b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -29.40933779 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR17 (microRNA 17) | Expression level of miR-17 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -63.09918737 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR17HG (miR-17-92 cluster host gene (non-protein coding)) | Gene expression showed a significant (p<E-3) decrease in the expression of MIR17HG in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -41.18 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| MIR181A1 (microRNA 181a-1) | Expression level of miR-181a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -40.74009933 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR181A1 (microRNA 181a-1) | MicroRNA level of miR-181a-5p showed a decrease in older individuals (mean age 64) when compared with younger controls (mean age 30) | Male and Female | 30 | 64 | Blood | 3453: Noren Hooten, N et al. (2013) "Age-related changes in microRNA levels in serum." Aging (Albany NY) 5(10):725-740 (24088671) | ||
| MIR181A2 (microRNA 181a-2) | MicroRNA level of miR-181a-5p showed a decrease in older individuals (mean age 64) when compared with younger controls (mean age 30) | Male and Female | 30 | 64 | Blood | 3453: Noren Hooten, N et al. (2013) "Age-related changes in microRNA levels in serum." Aging (Albany NY) 5(10):725-740 (24088671) | ||
| MIR183 (microRNA 183) | Expression level of miR-183* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 82.53008701 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR184 (microRNA 184) | Expression level of miR-184 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 52.13278979 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR18A (microRNA 18a) | MicroRNA level showed a significant (p<E-4) decrease in the expression of miR-18a from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | -89.8 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR18B (microRNA 18b) | Expression level of miR-18b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -39.33285003 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR191 (microRNA 191) | Expression level of miR-191 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -38.35663761 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR196A1 (microRNA 196a-1) | Expression level of miR-196a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -40.49744884 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR199A1 (microRNA 199a-1) | Expression level of miR-199a-3p/199b-3p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -39.99425153 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR199A1 (microRNA 199a-1) | Expression level of miR-199a-3p/199b-3p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -39.85796514 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR199A1 (microRNA 199a-1) | Expression level of miR-199a-5p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -26.45615697 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR199B (microRNA 199b) | Expression level of miR-199b-5p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -62.19124036 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR19A (microRNA 19a) | Expression level of miR-19a is significantly decreased in mesenchymal stem cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | Mesenchymal Stem Cell | -40.73026724 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR19A (microRNA 19a) | Expression level of miR-19a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -24.60681084 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR19A (microRNA 19a) | Expression level of miR-19a is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -49.00595031 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR19B1 (microRNA 19b-1) | Expression level of miR-19b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -63.54192801 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR200C (microRNA 200c) | Expression level of miR-200c is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -35.55872976 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR206 (microRNA 206) | Expression level of miR-206 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -47.42358866 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR20A (microRNA 20a) | MicroRNA level showed a significant (p<E-4) decrease in the expression of miR-20a from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | -94.2 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR20B (microRNA 20b) | Expression level of miR-20b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -53.29074374 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR21 (microRNA 21) | Expression level of miR-21 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -83.59939039 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR210 (microRNA 210) | Expression level of miR-210 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -21.84260838 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR212 (microRNA 212) | Expression level of miR-212 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -66.0492758 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR214 (microRNA 214) | Expression level of miR-214 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -27.09458454 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR221 (microRNA 221) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-221 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR23A (microRNA 23a) | Expression level of miR-23a is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 137.1939302 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR23B (microRNA 23b) | Expression level of miR-23b is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 32.79614927 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR24-1 (microRNA 24-1) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-24 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR24-2 (microRNA 24-2) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-24 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR26A1 (microRNA 26a-1) | Expression level of miR-26a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -27.46615314 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR27A (microRNA 27a) | Expression level of miR-27a is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -47.71839105 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR27B (microRNA 27b) | Expression level of miR-27b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -31.73098046 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR28 (microRNA 28) | Expression level of miR-28-5p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -38.07325363 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR29A (microRNA 29a) | Expression level of miR-29a is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 30.40432246 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR29B1 (microRNA 29b-1) | Expression level of miR-29b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -57.25032491 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR29C (microRNA 29c) | Expression level of miR-29c is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -29.54318021 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30B (microRNA 30b) | Expression level of miR-30b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -43.00511438 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30B (microRNA 30b) | Expression level of miR-30b* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 59.52568737 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30C1 (microRNA 30c-1) | Expression level of miR-30c is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -43.24047937 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30D (microRNA 30d) | Expression level of miR-30d is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -40.71624525 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30E (microRNA 30e) | Expression level of miR-30e is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -33.15182984 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30E (microRNA 30e) | Expression level of miR-30e is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -73.82882308 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR30E (microRNA 30e) | Expression level of miR-30e* is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -40.76226564 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR320B1 (microRNA 320b-1) | MicroRNA level showed a significant (p<E-4) increase in the expression of miR-320b from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | 1049.9 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR320B2 (microRNA 320b-2) | MicroRNA level showed a significant (p<E-4) increase in the expression of miR-320b from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | 1049.9 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR320D1 (microRNA 320d-1) | MicroRNA level showed a significant (p<E-4) increase in the expression of miR-320d from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | 529.9 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR320D2 (microRNA 320d-2) | MicroRNA level showed a significant (p<E-4) increase in the expression of miR-320d from blood samples of German centenarians and nonagenarians (mean age at the time of recruitment: 98.9 years) compared to younger controls (mean age at the time of enrollment: 43.8 years) | Male and Female | 45 | 96 | Blood | 529.9 | <0.001 | 3452: ElSharawy, A et al. (2012) "Genome-wide miRNA signatures of human longevity." Aging Cell 11(4):607-616 (22533606) |
| MIR326 (microRNA 326) | Expression level of miR-326 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -32.80748136 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR335 (microRNA 335) | Expression level of miR-335 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -57.15538287 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR335 (microRNA 335) | Expression level of miR-335 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -57.93470145 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR338 (microRNA 338) | Expression level of miR-338-3p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -61.67465399 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR340 (microRNA 340) | Expression level of miR-340 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -46.64030837 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR342 (microRNA 342) | Expression level of miR-342-3p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -36.54149688 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR342 (microRNA 342) | Expression level of miR-342-3p is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 57.50191219 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR361 (microRNA 361) | Expression level of miR-361-5p is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -24.89880959 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR374A (microRNA 374a) | Expression level of miR-374a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -36.13611207 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR374B (microRNA 374b) | Expression level of miR-374b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -37.92670721 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR376A1 (microRNA 376a-1) | Expression level of miR-376a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -31.31874117 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR381 (microRNA 381) | Expression level of miR-381 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 50.54887548 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR423 (microRNA 423) | Expression level of miR-423-3p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 33.76594085 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR424 (microRNA 424) | Expression level of miR-424 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -39.22191961 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR432 (microRNA 432) | Expression level of miR-432* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 37.12254738 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR451A (microRNA 451a) | Expression level of miR-451 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 110.9968213 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR483 (microRNA 483) | Expression level of miR-483-5p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 92.15722509 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR486 (microRNA 486) | Expression level of miR-486-5p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 72.48925493 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR487B (microRNA 487b) | Expression level of miR-487b is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -58.5805346 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR489 (microRNA 489) | Expression level of miR-489 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -29.76117731 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR491 (microRNA 491) | Expression level of miR-491-3p is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -45.92484981 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR492 (microRNA 492) | Expression level of miR-492 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 83.89723272 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR494 (microRNA 494) | Expression level of miR-494 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 24.97400511 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR496 (microRNA 496) | Genome-wide assessment, followed by rtPCR, of miRNA expression in the peripheral blood mononuclear cells between young (age 30) and old (age 64) patients shows that miR-496 has a significantly lower expression in older individuals. | Male and Female | -1 | -1 | Blood, Immune System | 2812: Noren Hooten et al. (2010) "microRNA expression patterns reveal differential expression of target genes with age." PLoS ONE 5(5):e10724 (20505758) | ||
| MIR498 (microRNA 498) | Expression level of miR-498 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -29.67819659 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR503HG (MIR503 host gene (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in MIR503HG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MIR512-1 (microRNA 512-1) | Expression level of miR-512-5p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 26.04598497 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR518A1 (microRNA 518a-1) | Expression level of miR-518a-5p/527 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 38.55100302 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR518C (microRNA 518c) | Expression level of miR-518c* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 55.54795576 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR518D (microRNA 518d) | Expression level of miR-518d-5p/518f*/520c-5p/526a is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 41.43034314 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR519D (microRNA 519d) | Expression level of miR-519d is significantly decreased in mesenchymal stem cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | Mesenchymal Stem Cell | -44.70047638 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR519D (microRNA 519d) | Expression level of miR-519d is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -61.58384839 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR519E (microRNA 519e) | Expression level of miR-519e* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 88.83022063 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR525 (microRNA 525) | Expression level of miR-525-5p is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -61.38102312 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR525 (microRNA 525) | Expression level of miR-525-5p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 102.475888 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR526B (microRNA 526b) | Expression level of miR-526b is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 50.21656589 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR543 (microRNA 543) | Expression level of miR-543 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 40.66315114 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR583 (microRNA 583) | Expression level of miR-583 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 105.4245302 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR584 (microRNA 584) | Expression level of miR-584 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 40.89226779 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR590 (microRNA 590) | Expression level of miR-590-5p is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -55.80327827 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR602 (microRNA 602) | Expression level of miR-602 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 39.04096531 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR642A (microRNA 642a) | Expression level of miR-642 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -27.53022762 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR658 (microRNA 658) | Expression level of miR-658 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 65.65478753 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR668 (microRNA 668) | Expression level of miR-668 is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 251.3577246 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR671 (microRNA 671) | Expression level of miR-671-5p is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 45.93859491 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR675 (microRNA 675) | Expression level of miR-675 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 68.98168599 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR744 (microRNA 744) | Expression level of miR-744 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -28.85903186 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR765 (microRNA 765) | Expression level of miR-765 is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 117.1928508 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR96 (microRNA 96) | Expression level of miR-96* is significantly increased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | 62.44505659 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR98 (microRNA 98) | Expression level of miR-98 is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -43.76695802 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR98 (microRNA 98) | Expression level of miR-98 is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -18.90982526 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR99A (microRNA 99a) | Expression level of miR-99a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -49.91098759 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIR99B (microRNA 99b) | Expression level of miR-99b is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -25.2805164 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7A1 (microRNA let-7a-1) | Expression level of let-7a is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -36.57002887 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7C (microRNA let-7c) | Expression level of let-7c is significantly increased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | 33.63957266 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7D (microRNA let-7d) | Expression level of let-7d is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -25.78825365 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7F1 (microRNA let-7f-1) | Expression level of let-7f is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -34.46205163 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7F1 (microRNA let-7f-1) | Expression level of let-7f is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -65.56927071 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7G (microRNA let-7g) | Expression level of let-7g is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -32.90181338 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7I (microRNA let-7i) | Expression level of let-7i is significantly decreased in foreskin cells from elderly when compared with younger controls. | Male | -1 | -1 | Foreskin | -18.72576513 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIRLET7I (microRNA let-7i) | Expression level of let-7i is significantly decreased in T cells from elderly when compared with younger controls. | Male and Female | -1 | -1 | T Cell | -46.85444339 | <0.001 | 2690: Hackl et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296 (20089119) |
| MIS18BP1 (MIS18 binding protein 1) | Using a linear mixed model, differential expression with age was identified in MIS18BP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MISP (mitotic spindle positioning) | Comparison of DNA methylation showed a significantly decreased methylation level of C19orf21 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| MISP (mitotic spindle positioning) | Comparison of DNA methylation showed a significantly decreased methylation level of C19orf21 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -24.8 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| MKRN1 (makorin ring finger protein 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MKRNP5 (makorin ring finger protein pseudogene 5) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MLANA (melan-A) | Using a linear mixed model, differential expression with age was identified in MLANA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MLC1 (megalencephalic leukoencephalopathy with subcortical cysts 1) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MLEC (Malectin) | Using a linear mixed model, differential expression with age was identified in MLEC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MLEC (Malectin) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MLF2 (myeloid leukemia factor 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of MLF2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MLKL (mixed lineage kinase domain-like) | Using a linear mixed model, differential expression with age was identified in MLKL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MLKL (mixed lineage kinase domain-like) | Male and Female | 20 | 75 | Skeletal Muscle | -7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10) | Using a linear mixed model, differential expression with age was identified in MLLT10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MLLT11 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of MLLT11 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| MMD (monocyte to macrophage differentiation-associated) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MMGT1 (membrane magnesium transporter 1) | Using a linear mixed model, differential expression with age was identified in MMGT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mmp14 (matrix metallopeptidase 14 (membrane-inserted)) | Male and Female | 6 | 22 | Liver | 5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MMP28 (matrix metallopeptidase 28) | Using a linear mixed model, differential expression with age was identified in MMP28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MMP7 (matrix metallopeptidase 7 (matrilysin, uterine)) | Male and Female | 27 | 92 | Kidney | 23.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| MMRN1 (multimerin 1) | Using a linear mixed model, differential expression with age was identified in MMRN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mmrn1 (multimerin 1) | Male and Female | 2 | 26 | Lung | 9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| MMS19 (MMS19 nucleotide excision repair homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in MMS19 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mn1 (meningioma 1) | Male and Female | 3 | 23 | Hematological System | -10.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| MOB3B (MOB kinase activator 3B) | Using a linear mixed model, differential expression with age was identified in MOB3B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mocos (molybdenum cofactor sulfurase) | Male and Female | 3 | 23 | Hematological System | 18.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| MOCS1 (molybdenum cofactor synthesis 1) | Using a linear mixed model, differential expression with age was identified in MOCS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MOGAT1 (monoacylglycerol O-acyltransferase 1) | Using a linear mixed model, differential expression with age was identified in MOGAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mogs (mannosyl-oligosaccharide glucosidase) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| MON2 (MON2 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in MON2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MORC4 (MORC family CW-type zinc finger 4) | Using a linear mixed model, differential expression with age was identified in MORC4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Morf4l2 (mortality factor 4 like 2) | Male and Female | 6 | 22 | Liver | 4.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MORN2 (MORN repeat containing 2) | Using a linear mixed model, differential expression with age was identified in MORN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MORN5 (MORN repeat containing 5) | Male and Female | 20 | 75 | Skeletal Muscle | -20.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Mos (Moloney sarcoma oncogene) | Male and Female | 6 | 22 | Liver | -28.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MPC2 (mitochondrial pyruvate carrier 2) | Using a linear mixed model, differential expression with age was identified in MPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MPDU1 (mannose-P-dolichol utilization defect 1) | Using a linear mixed model, differential expression with age was identified in MPDU1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mpdu1 (mannose-P-dolichol utilization defect 1) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Mpeg1 (macrophage expressed gene 1) | Male and Female | 2 | 15 | Hippocampus | 7.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| MPST (mercaptopyruvate sulfurtransferase) | Using a linear mixed model, differential expression with age was identified in MPST in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MPZL1 (myelin protein zero-like 1) | Using a linear mixed model, differential expression with age was identified in MPZL1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MPZL2 (myelin protein zero-like 2) | Using a linear mixed model, differential expression with age was identified in MPZL2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MR1 (major histocompatibility complex, class I-related) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus MR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 46.64 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MR1 (major histocompatibility complex, class I-related) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe MR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 22.37 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MR1 (major histocompatibility complex, class I-related) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe MR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 32.21 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MRFAP1L1 (Morf4 family associated protein 1-like 1) | Using a linear mixed model, differential expression with age was identified in MRFAP1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mrgpra4 (MAS-related GPR, member A4) | Male and Female | 5 | 22 | Brain | -92.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| MRI1 (methylthioribose-1-phosphate isomerase 1) | Using a linear mixed model, differential expression with age was identified in MRI1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mrp63 (mitochondrial ribosomal protein 63) | Male and Female | 5 | 30 | Anatomical System | -27.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| MRPL11 (mitochondrial ribosomal protein L11) | Using a linear mixed model, differential expression with age was identified in MRPL11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL12 (mitochondrial ribosomal protein L12) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPL14 (mitochondrial ribosomal protein L14) | Using a linear mixed model, differential expression with age was identified in MRPL14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL18 (mitochondrial ribosomal protein L18) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPL27 (mitochondrial ribosomal protein L27) | Using a linear mixed model, differential expression with age was identified in MRPL27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL33 (mitochondrial ribosomal protein L33) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MRPL37 (mitochondrial ribosomal protein L37) | Using a linear mixed model, differential expression with age was identified in MRPL37 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL41 (mitochondrial ribosomal protein L41) | Using a linear mixed model, differential expression with age was identified in MRPL41 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL41 (mitochondrial ribosomal protein L41) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPL43 (mitochondrial ribosomal protein L43) | Gene expression showed a significant (p<E-3) increase in the expression of MRPL43 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 151.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| MRPL48 (mitochondrial ribosomal protein L48) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPL51 (mitochondrial ribosomal protein L51) | Using a linear mixed model, differential expression with age was identified in MRPL51 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL53 (mitochondrial ribosomal protein L53) | Using a linear mixed model, differential expression with age was identified in MRPL53 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPL55 (mitochondrial ribosomal protein L55) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of MRPL55 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| MRPS11 (mitochondrial ribosomal protein S11) | Using a linear mixed model, differential expression with age was identified in MRPS11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPS12 (mitochondrial ribosomal protein S12) | Using a linear mixed model, differential expression with age was identified in MRPS12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPS12 (mitochondrial ribosomal protein S12) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Mrps12 (mitochondrial ribosomal protein S12) | Male and Female | 6 | 22 | Liver | 5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| MRPS15 (mitochondrial ribosomal protein S15) | Using a linear mixed model, differential expression with age was identified in MRPS15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPS15 (mitochondrial ribosomal protein S15) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPS22 (mitochondrial ribosomal protein S22) | Male and Female | 20 | 75 | Skeletal Muscle | -1.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Mrps23 (mitochondrial ribosomal protein S23) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MRPS24 (mitochondrial ribosomal protein S24) | Using a linear mixed model, differential expression with age was identified in MRPS24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPS24 (mitochondrial ribosomal protein S24) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPS25 (mitochondrial ribosomal protein S25) | Using a linear mixed model, differential expression with age was identified in MRPS25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MRPS30 (mitochondrial ribosomal protein S30) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MRPS7 (mitochondrial ribosomal protein S7) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MS4A6A (membrane-spanning 4-domains, subfamily A, member 6A) | Using a linear mixed model, differential expression with age was identified in MS4A6A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MS4A7 (membrane-spanning 4-domains, subfamily A, member 7) | Using a linear mixed model, differential expression with age was identified in MS4A7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MSC (musculin) | Using a linear mixed model, differential expression with age was identified in MSC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Msl2 (Male-specific lethal 2 homolog (Drosophila)) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| MSMO1 (methylsterol monooxygenase 1) | Using a linear mixed model, differential expression with age was identified in MSMO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MSRA (methionine sulfoxide reductase A) | Using a linear mixed model, differential expression with age was identified in MSRA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MSRB1 (methionine sulfoxide reductase B1) | Using a linear mixed model, differential expression with age was identified in MSRB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MSRB2 (methionine sulfoxide reductase B2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of MSRB2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) | Using a linear mixed model, differential expression with age was identified in MST1R in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MSX1 (msh homeobox 1) | Using a linear mixed model, differential expression with age was identified in MSX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MT1E (metallothionein 1E) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MT1G (metallothionein 1G) | Using a linear mixed model, differential expression with age was identified in MT1G in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MT2A (metallothionein 2A) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Mtap (methylthioadenosine phosphorylase) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Mthfd1 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, ) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Mtm1 (X-linked myotubular myopathy gene 1) | Male and Female | 5 | 25 | Skeletal Muscle | -14.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| MTMR10 (myotubularin related protein 10) | Using a linear mixed model, differential expression with age was identified in MTMR10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MTMR14 (myotubularin related protein 14) | Using a linear mixed model, differential expression with age was identified in MTMR14 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MTOR (mechanistic target of rapamycin (serine/threonine kinase)) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) | Using a linear mixed model, differential expression with age was identified in MTR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MTSS1 (metastasis suppressor 1) | Using a linear mixed model, differential expression with age was identified in MTSS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MTSS1 (metastasis suppressor 1) | Comparison of DNA methylation showed a significantly decreased methylation level of MTSS1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.5 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| MTX2 (metaxin 2) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MUC1 (mucin 1, cell surface associated) | Using a linear mixed model, differential expression with age was identified in MUC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MUC7 (mucin 7, secreted) | Using a linear mixed model, differential expression with age was identified in MUC7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MUL1 (mitochondrial E3 ubiquitin protein ligase 1) | Using a linear mixed model, differential expression with age was identified in MUL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MUSK (muscle, skeletal, receptor tyrosine kinase) | Using a linear mixed model, differential expression with age was identified in MUSK in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MVD (mevalonate (diphospho) decarboxylase) | Using a linear mixed model, differential expression with age was identified in MVD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MVK (mevalonate kinase) | Using a linear mixed model, differential expression with age was identified in MVK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mxi1 (Max interacting protein 1) | Male and Female | 2 | 26 | Lung | 4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| MXRA5 (matrix-remodelling associated 5) | Using a linear mixed model, differential expression with age was identified in MXRA5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Mybph (myosin binding protein H) | Male and Female | 5 | 25 | Skeletal Muscle | 37.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| MYD88 (myeloid differentiation primary response 88) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus MYD88 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 59.28 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MYD88 (myeloid differentiation primary response 88) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe MYD88 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 54.79 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MYD88 (myeloid differentiation primary response 88) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe MYD88 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 58.67 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| MYH11 (myosin, heavy chain 11, smooth muscle) | Using a linear mixed model, differential expression with age was identified in MYH11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYH15 (myosin, heavy chain 15) | Using a linear mixed model, differential expression with age was identified in MYH15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) | Male and Female | 20 | 75 | Skeletal Muscle | 20.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MYL12A (myosin, light chain 12A, regulatory, non-sarcomeric) | Using a linear mixed model, differential expression with age was identified in MYL12A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYL4 (myosin, light chain 4, alkali; atrial, embryonic) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of MYL4 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Myl6 (myosin, light polypeptide 6, alkali, smooth muscle and non-muscle) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Myl9 (myosin, light polypeptide 9, regulatory) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Mylk (myosin, light polypeptide kinase) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| MYO10 (myosin X) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MYO3A (myosin IIIA) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of MYO3A and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| MYO6 (myosin VI) | Male and Female | 26 | 106 | Brain | 18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| MYOC (myocilin, trabecular meshwork inducible glucocorticoid response) | Using a linear mixed model, differential expression with age was identified in MYOC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYOD1 (myogenic differentiation 1) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| MYOD1 (myogenic differentiation 1) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| MYOD1 (myogenic differentiation 1) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| MYOD1 (myogenic differentiation 1) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| MYOF (myoferlin) | Using a linear mixed model, differential expression with age was identified in MYOF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYOM2 (myomesin (M-protein) 2, 165kDa) | Using a linear mixed model, differential expression with age was identified in MYOM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYOM2 (myomesin (M-protein) 2, 165kDa) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| MYOM3 (myomesin 3) | Using a linear mixed model, differential expression with age was identified in MYOM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| MYOT (myotilin) | Using a linear mixed model, differential expression with age was identified in MYOT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Myoz1 (myozenin 1) | Male and Female | 5 | 25 | Skeletal Muscle | -1.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| N4BP2L1 (NEDD4 binding protein 2-like 1) | Using a linear mixed model, differential expression with age was identified in N4BP2L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NAB1 (NGFI-A binding protein 1 (EGR1 binding protein 1)) | Gene expression showed a significant (p<E-3) decrease in the expression of NAB1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -47.92 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| NAP1L4 (nucleosome assembly protein 1-like 4) | Using a linear mixed model, differential expression with age was identified in NAP1L4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NAPA (N-ethylMaleimide-sensitive factor attachment protein, alpha) | Male and Female | 26 | 106 | Brain | -13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NAPG (N-ethylMaleimide-sensitive factor attachment protein, gamma) | Male and Female | 26 | 106 | Brain | -23.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NAPSB (napsin B aspartic peptidase, pseudogene) | Using a linear mixed model, differential expression with age was identified in NAPSB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Narf (nuclear prelamin A recognition factor) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial (putative)) | Using a linear mixed model, differential expression with age was identified in NARS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nat15 (N-acetyltransferase 15 (GCN5-related, putative)) | Male and Female | 2 | 15 | Hippocampus | -1.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| NAT9 (N-acetyltransferase 9 (GCN5-related, putative)) | Using a linear mixed model, differential expression with age was identified in NAT9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nav1 (neuron navigator 1) | Male and Female | 3 | 23 | Hematological System | 25.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Nbea (neurobeachin) | Male and Female | 8 | 24 | Muscle | 10.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NBEAL2 (neurobeachin-like 2) | Using a linear mixed model, differential expression with age was identified in NBEAL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NBPF10 (neuroblastoma breakpoint family, member 10) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NCALD (neurocalcin delta) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Ncald (neurocalcin delta) | Male and Female | 2 | 26 | Lung | -7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| NCAM2 (neural cell adhesion molecule 2) | Using a linear mixed model, differential expression with age was identified in NCAM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NCAPG (non-SMC condensin I complex, subunit G) | Using a linear mixed model, differential expression with age was identified in NCAPG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NCF1C (neutrophil cytosolic factor 1C pseudogene) | Male and Female | 22 | 73 | Skeletal Muscle | -4.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| NCF4 (neutrophil cytosolic factor 4, 40kDa) | Using a linear mixed model, differential expression with age was identified in NCF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NCOA6 (nuclear receptor coactivator 6) | Using a linear mixed model, differential expression with age was identified in NCOA6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NCOR2 (nuclear receptor corepressor 2) | Using a linear mixed model, differential expression with age was identified in NCOR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NCOR2 (nuclear receptor corepressor 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of NCOR2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| NCRNA00116 (non-protein coding RNA 116) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NCS1 (neuronal calcium sensor 1) | Using a linear mixed model, differential expression with age was identified in NCS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ndc80 (NDC80 homolog, kinetochore complex component (S. cerevisiae)) | Male and Female | 3 | 23 | Hematological System | -20.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| NDP (Norrie disease (pseudoglioma)) | Male and Female | 26 | 106 | Brain | 9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NDUFA10 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NDUFA11 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa) | Using a linear mixed model, differential expression with age was identified in NDUFA11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFA12 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NDUFA8 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa) | Using a linear mixed model, differential expression with age was identified in NDUFA8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFA9 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NDUFAF3 (NADH dehydrogenase (ubiquinone) complex I, assembly factor 3) | Using a linear mixed model, differential expression with age was identified in NDUFAF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFAF5 (NADH dehydrogenase (ubiquinone) complex I, assembly factor 5) | Using a linear mixed model, differential expression with age was identified in NDUFAF5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFAF7 (NADH dehydrogenase (ubiquinone) complex I, assembly factor 7) | Using a linear mixed model, differential expression with age was identified in NDUFAF7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFB11 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa) | Using a linear mixed model, differential expression with age was identified in NDUFB11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFB2 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa) | Using a linear mixed model, differential expression with age was identified in NDUFB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NDUFB3 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ndufb4 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4) | Male and Female | 8 | 24 | Muscle | -1.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NDUFB4 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ndufb5 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5) | Male and Female | 5 | 30 | Anatomical System | -1.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Ndufc1 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NDUFC1 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NDUFS5 (NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of NDUFS5 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| NDUFV2 (NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NEDD1 (neural precursor cell expressed, developmentally down-regulated 1) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NEFH (neurofilament, heavy polypeptide) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of NEFH and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Neil1 (nei endonuclease VIII-like 1 (E. coli)) | Male and Female | 3 | 23 | Hematological System | 18.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| NEK11 (NIMA-related kinase 11) | Using a linear mixed model, differential expression with age was identified in NEK11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NEK3 (NIMA-related kinase 3) | Using a linear mixed model, differential expression with age was identified in NEK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NEK7 (NIMA (never in mitosis gene a)-related kinase 7) | Male and Female | 26 | 106 | Brain | 17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NETO2 (neuropilin (NRP) and tolloid (TLL)-like 2) | Using a linear mixed model, differential expression with age was identified in NETO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2) | Male and Female | 3 | 23 | Hematological System | -19.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| NEU3 (sialidase 3 (membrane sialidase)) | Male and Female | 20 | 75 | Skeletal Muscle | -8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NEXN (nexilin (F actin binding protein)) | Using a linear mixed model, differential expression with age was identified in NEXN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NFAT5 (nuclear factor of activated T-cells 5, tonicity-responsive) | Using a linear mixed model, differential expression with age was identified in NFAT5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NFKBIZ (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta) | Using a linear mixed model, differential expression with age was identified in NFKBIZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nfs1 (nitrogen fixation gene 1 (S. cerevisiae)) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NGEF (neuronal guanine nucleotide exchange factor) | Using a linear mixed model, differential expression with age was identified in NGEF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NGF (nerve growth factor (beta polypeptide)) | Comparison of DNA methylation showed a significantly decreased methylation level of NGFB in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -22.5 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| NGF (nerve growth factor (beta polypeptide)) | Comparison of DNA methylation showed a significantly increased methylation level of NGF in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 19.3 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| NHLRC1 (NHL repeat containing E3 ubiquitin protein ligase 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of NHLRC1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| NIF3L1 (NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in NIF3L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NIPA2 (non imprinted in Prader-Willi/Angelman syndrome 2) | Using a linear mixed model, differential expression with age was identified in NIPA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NIPBL (Nipped-B homolog (Drosophila)) | Using a linear mixed model, differential expression with age was identified in NIPBL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NISCH (nischarin) | Using a linear mixed model, differential expression with age was identified in NISCH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nisch (nischarin) | Male and Female | 5 | 25 | Skeletal Muscle | 3.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Nit2 (nitrilase family, member 2) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| NKD2 (naked cuticle homolog 2 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in NKD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nktr (natural killer tumor recognition sequence) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| NKTR (natural killer-tumor recognition sequence) | Using a linear mixed model, differential expression with age was identified in NKTR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NKTR (natural killer-tumor recognition sequence) | Gene expression showed a significant (p<E-3) decrease in the expression of NKTR in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -37.5 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| NKX2-2 (NK2 homeobox 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of NKX2-2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| NKX2-2 (NK2 homeobox 2) | Male and Female | 26 | 106 | Brain | 14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NLRP1 (NLR family, pyrin domain containing 1) | Using a linear mixed model, differential expression with age was identified in NLRP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NLRP1 (NLR family, pyrin domain containing 1) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe NLRP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -29.44 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| NLRP1 (NLR family, pyrin domain containing 1) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe NLRP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -24.82 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| NMB (neuromedin B) | Using a linear mixed model, differential expression with age was identified in NMB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NME3 (NME/NM23 nucleoside diphosphate kinase 3) | Using a linear mixed model, differential expression with age was identified in NME3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NME6 (NME/NM23 nucleoside diphosphate kinase 6) | Using a linear mixed model, differential expression with age was identified in NME6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NME8 (NME/NM23 family member 8) | Using a linear mixed model, differential expression with age was identified in NME8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nmnat2 (nicotinamide nucleotide adenylyltransferase 2) | Male and Female | 2 | 26 | Lung | -7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| NMNAT3 (nicotinamide nucleotide adenylyltransferase 3) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NMRK1 (nicotinamide riboside kinase 1) | Using a linear mixed model, differential expression with age was identified in NMRK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NMT2 (N-myristoyltransferase 2) | Using a linear mixed model, differential expression with age was identified in NMT2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NNMT (nicotinamide N-methyltransferase) | Using a linear mixed model, differential expression with age was identified in NNMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NNMT (nicotinamide N-methyltransferase) | Male and Female | 20 | 75 | Skeletal Muscle | 17.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NNMT (nicotinamide N-methyltransferase) | Male and Female | 27 | 92 | Kidney | 40.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| NNT (nicotinamide nucleotide transhydrogenase) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NOD2 (nucleotide-binding oligomerization domain containing 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of NOD2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| NOL12 (nucleolar protein 12) | Using a linear mixed model, differential expression with age was identified in NOL12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NOL3 (nucleolar protein 3 (apoptosis repressor with CARD domain)) | Using a linear mixed model, differential expression with age was identified in NOL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NOLC1 (nucleolar and coiled-body phosphoprotein 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| NOP10 (NOP10 ribonucleoprotein) | Using a linear mixed model, differential expression with age was identified in NOP10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NOP58 (NOP58 ribonucleoprotein) | Using a linear mixed model, differential expression with age was identified in NOP58 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NOTCH3 (notch 3) | Using a linear mixed model, differential expression with age was identified in NOTCH3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NOXA1 (NADPH oxidase activator 1) | Using a linear mixed model, differential expression with age was identified in NOXA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPAS2 (neuronal PAS domain protein 2) | Using a linear mixed model, differential expression with age was identified in NPAS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPC2 (Niemann-Pick disease, type C2) | Using a linear mixed model, differential expression with age was identified in NPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPDC1 (neural proliferation, differentiation and control, 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of NPDC1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| NPEPL1 (aminopeptidase-like 1) | Using a linear mixed model, differential expression with age was identified in NPEPL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPL (N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)) | Using a linear mixed model, differential expression with age was identified in NPL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPM3 (nucleophosmin/nucleoplasmin 3) | Using a linear mixed model, differential expression with age was identified in NPM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPM3 (nucleophosmin/nucleoplasmin 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of NPM3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| NPR2 (natriuretic peptide receptor 2) | Using a linear mixed model, differential expression with age was identified in NPR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NPR3 (natriuretic peptide receptor 3) | Using a linear mixed model, differential expression with age was identified in NPR3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nptn (neuroplastin) | Male and Female | 2 | 26 | Lung | 2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Npy (neuropeptide Y) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| NR1D2 (nuclear receptor subfamily 1, group D, member 2) | Using a linear mixed model, differential expression with age was identified in NR1D2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NR1H2 (nuclear receptor subfamily 1, group H, member 2) | Gene expression showed a significant (p<E-3) increase in the expression of NR1H2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 77.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| NR2C2AP (nuclear receptor 2C2-associated protein) | Using a linear mixed model, differential expression with age was identified in NR2C2AP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NR2E1 (nuclear receptor subfamily 2, group E, member 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of NR2E1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| NR2F6 (nuclear receptor subfamily 2, group F, member 6) | Using a linear mixed model, differential expression with age was identified in NR2F6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NRBP2 (nuclear receptor binding protein 2) | Using a linear mixed model, differential expression with age was identified in NRBP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NRG2 (neuregulin 2) | Using a linear mixed model, differential expression with age was identified in NRG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NRGN (neurogranin (protein kinase C substrate, RC3)) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Nrp1 (neuropilin 1) | Male and Female | 5 | 22 | Brain | -5.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| NRROS (negative regulator of reactive oxygen species) | Using a linear mixed model, differential expression with age was identified in NRROS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NRXN1 (neurexin 1) | Male and Female | 26 | 106 | Brain | -15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NSDHL (NAD(P) dependent steroid dehydrogenase-like) | Using a linear mixed model, differential expression with age was identified in NSDHL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NSF (N-ethylMaleimide-sensitive factor) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NSMCE4A (non-SMC element 4 homolog A (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in NSMCE4A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Nsmce4a (non-SMC element 4 homolog A (S. cerevisiae)) | Male and Female | 5 | 25 | Skeletal Muscle | -6.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| NSUN7 (NOP2/Sun domain family, member 7) | Using a linear mixed model, differential expression with age was identified in NSUN7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NT5C2 (5'-nucleotidase, cytosolic II) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ntf3 (neurotrophin 3) | Male and Female | 3 | 23 | Hematological System | 34.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| NTF4 (neurotrophin 4) | Using a linear mixed model, differential expression with age was identified in NTF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NTM (neurotrimin) | Using a linear mixed model, differential expression with age was identified in NTM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NTN5 (netrin 5) | Using a linear mixed model, differential expression with age was identified in NTN5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NTRK3 (neurotrophic tyrosine kinase, receptor, type 3) | Using a linear mixed model, differential expression with age was identified in NTRK3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NTSR2 (neurotensin receptor 2) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Nucks1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) | Male and Female | 6 | 22 | Liver | 6.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21) | Male and Female | 26 | 106 | Brain | -28.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NUFIP1 (nuclear fragile X mental retardation protein interacting protein 1) | Male and Female | 26 | 106 | Brain | -24.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| NUP205 (nucleoporin 205kDa) | Using a linear mixed model, differential expression with age was identified in NUP205 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NUP85 (nucleoporin 85kDa) | Using a linear mixed model, differential expression with age was identified in NUP85 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NUPL2 (nucleoporin like 2) | Gene expression showed a significant (p<E-3) increase in the expression of NUPL2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 59.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| NXF1 (nuclear RNA export factor 1) | Using a linear mixed model, differential expression with age was identified in NXF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NXPE2 (neurexophilin and PC-esterase domain family, member 2) | Using a linear mixed model, differential expression with age was identified in NXPE2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| NXT2 (nuclear transport factor 2-like export factor 2) | Male and Female | 26 | 106 | Brain | 22.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OAF (OAF homolog (Drosophila)) | Using a linear mixed model, differential expression with age was identified in OAF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa) | Using a linear mixed model, differential expression with age was identified in OAS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OAZ1 (ornithine decarboxylase antizyme 1) | Using a linear mixed model, differential expression with age was identified in OAZ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OAZ1 (ornithine decarboxylase antizyme 1) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OCA2 (oculocutaneous albinism II) | Using a linear mixed model, differential expression with age was identified in OCA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OCEL1 (occludin/ELL domain containing 1) | Using a linear mixed model, differential expression with age was identified in OCEL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) | Using a linear mixed model, differential expression with age was identified in OGT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLAH (oleoyl-ACP hydrolase) | Using a linear mixed model, differential expression with age was identified in OLAH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLFM1 (olfactomedin 1) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OLFM2 (olfactomedin 2) | Using a linear mixed model, differential expression with age was identified in OLFM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLFML1 (olfactomedin-like 1) | Using a linear mixed model, differential expression with age was identified in OLFML1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLFML2B (olfactomedin-like 2B) | Using a linear mixed model, differential expression with age was identified in OLFML2B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLFML3 (olfactomedin-like 3) | Using a linear mixed model, differential expression with age was identified in OLFML3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OLIG2 (oligodendrocyte lineage transcription factor 2) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OMD (osteomodulin) | Using a linear mixed model, differential expression with age was identified in OMD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OR2B6 (olfactory receptor, family 2, subfamily B, member 6) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of OR2B6 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| OR2H2 (olfactory receptor, family 2, subfamily H, member 2) | Male and Female | 26 | 106 | Brain | -16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OR5V1 (olfactory receptor, family 5, subfamily V, member 1) | Comparison of DNA methylation showed a significantly increased methylation level of OR5V1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 15.3 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ORC2 (origin recognition complex, subunit 2) | Using a linear mixed model, differential expression with age was identified in ORC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ORC4L (origin recognition complex, subunit 4-like (yeast)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Orc6l (origin recognition complex, subunit 6-like (S. cerevisiae)) | Male and Female | 5 | 25 | Skeletal Muscle | -7.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1) | Using a linear mixed model, differential expression with age was identified in ORMDL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OSBP (oxysterol binding protein) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OSER1 (oxidative stress responsive serine-rich 1) | Using a linear mixed model, differential expression with age was identified in OSER1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Osmr (oncostatin M receptor) | Male and Female | 2 | 15 | Hippocampus | 9.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| OSTF1 (osteoclast stimulating factor 1) | Male and Female | 26 | 106 | Brain | -29.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) | Using a linear mixed model, differential expression with age was identified in OTUB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ovca2 (candidate tumor suppressor in ovarian cancer 2) | Male and Female | 2 | 26 | Lung | 4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| OVGP1 (oviductal glycoprotein 1, 120kDa) | Using a linear mixed model, differential expression with age was identified in OVGP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OXER1 (oxoeicosanoid (OXE) receptor 1) | Using a linear mixed model, differential expression with age was identified in OXER1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OXT (oxytocin/neurophysin I prepropeptide) | Using a linear mixed model, differential expression with age was identified in OXT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| OXT (oxytocin/neurophysin I prepropeptide) | Using a linear mixed model, differential expression with age was identified in OXT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Oxtr (oxytocin receptor) | Male and Female | 4 | 15 | Cochlea | 19.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| P2RX2 (purinergic receptor P2X, ligand-gated ion channel, 2) | Using a linear mixed model, differential expression with age was identified in P2RX2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7) | Using a linear mixed model, differential expression with age was identified in P2RX7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| P4HA1 (prolyl 4-hydroxylase, alpha polypeptide I) | Using a linear mixed model, differential expression with age was identified in P4HA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| P4HA2 (prolyl 4-hydroxylase, alpha polypeptide II) | Using a linear mixed model, differential expression with age was identified in P4HA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| P4HA2 (prolyl 4-hydroxylase, alpha polypeptide II) | Using a linear mixed model, differential expression with age was identified in P4HA2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PABPN1 (poly(A) binding protein, nuclear 1) | Using a linear mixed model, differential expression with age was identified in PABPN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PADI3 (peptidyl arginine deiminase, type III) | Using a linear mixed model, differential expression with age was identified in PADI3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PADI4 (peptidyl arginine deiminase, type IV) | Using a linear mixed model, differential expression with age was identified in PADI4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PAFAH2 (platelet-activating factor acetylhydrolase 2, 40kDa) | Using a linear mixed model, differential expression with age was identified in PAFAH2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PAK1 (p21 protein (Cdc42/Rac)-activated kinase 1) | Male and Female | 26 | 106 | Brain | -23.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PAK6 (p21 protein (Cdc42/Rac)-activated kinase 6) | Using a linear mixed model, differential expression with age was identified in PAK6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PAK7 (p21 protein (Cdc42/Rac)-activated kinase 7) | Using a linear mixed model, differential expression with age was identified in PAK7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PAN2 (PAN2 poly(A) specific ribonuclease subunit) | Using a linear mixed model, differential expression with age was identified in PAN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PANK1 (pantothenate kinase 1) | Using a linear mixed model, differential expression with age was identified in PANK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Panx1 (pannexin 1) | Male and Female | 8 | 24 | Muscle | 28.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PANX1 (pannexin 1) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe PANX1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -59.93 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PANX1 (pannexin 1) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe PANX1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -50.03 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PANX1 (pannexin 1) | Gene expression showed a significant (p<0.01) decrease in the expression of temporal lobe PANX1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | -41.63 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PANX2 (pannexin 2) | Using a linear mixed model, differential expression with age was identified in PANX2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PANX2 (pannexin 2) | Gene expression showed a significant (p<0.01) decrease in the expression of hippocampus PANX3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | -19.05 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PANX2 (pannexin 2) | Gene expression showed a significant (p<0.01) decrease in the expression of temporal lobe PANX4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | -16.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PANX2 (pannexin 2) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe PANX2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -8.11 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| PAPLN (papilin, proteoglycan-like sulfated glycoprotein) | Using a linear mixed model, differential expression with age was identified in PAPLN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PAQR6 (progestin and adipoQ receptor family member VI) | Using a linear mixed model, differential expression with age was identified in PAQR6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pard6a (par-6 (partitioning defective 6,) homolog alpha (C. elegans)) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PARM1 (prostate androgen-regulated mucin-like protein 1) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PARP1 (poly (ADP-ribose) polymerase 1) | In human pelvic skin samples obtained from patients aged between 15-77 and newborn babies (0-1 year old) PARP activity significantly increased with age in Males and inversely correlated with tissue NAD(+) levels. These associations were less evident in Females. | Male and Female | 0 | 77 | Skin | 2933: Massudi et al. (2012) "Age-associated changes in oxidative stress and NAD+ metabolism in human tissue." PLoS ONE 7(7):e42357 (22848760) | ||
| PARP14 (poly (ADP-ribose) polymerase family, member 14) | Using a linear mixed model, differential expression with age was identified in PARP14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PARP2 (poly (ADP-ribose) polymerase 2) | Using a linear mixed model, differential expression with age was identified in PARP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PARP3 (poly (ADP-ribose) polymerase family, member 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PARP3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PARVB (parvin, beta) | Using a linear mixed model, differential expression with age was identified in PARVB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PARVG (parvin, gamma) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PAXBP1 (PAX3 and PAX7 binding protein 1) | Using a linear mixed model, differential expression with age was identified in PAXBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pbx2 (pre B-cell leukemia transcription factor 2) | Male and Female | 6 | 22 | Liver | 28.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| PC (pyruvate carboxylase) | Using a linear mixed model, differential expression with age was identified in PC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCBD1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha) | Using a linear mixed model, differential expression with age was identified in PCBD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCBD2 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2) | Using a linear mixed model, differential expression with age was identified in PCBD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCBP1 (poly(rC) binding protein 1) | Gene expression showed a significant (p<E-3) increase in the expression of PCBP1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 59.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| PCCB (propionyl CoA carboxylase, beta polypeptide) | Using a linear mixed model, differential expression with age was identified in PCCB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pcdh12 (protocadherin 12) | Male and Female | 2 | 26 | Lung | -20.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PCDH7 (protocadherin 7) | Using a linear mixed model, differential expression with age was identified in PCDH7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCDH9 (protocadherin 9) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of PCDH9 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PCDHA1 (protocadherin alpha 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PCDHA1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PCDHA2 (protocadherin alpha 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PCDHA2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PCDHA3 (protocadherin alpha 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PCDHA3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PCDHA4 (protocadherin alpha 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PCDHA4 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Pcdhb21 (protocadherin beta 21) | Male and Female | 3 | 23 | Hematological System | 75.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Pcdhb9 (protocadherin beta 9) | Male and Female | 5 | 22 | Brain | 7.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| PCF11 (PCF11 cleavage and polyadenylation factor subunit) | Using a linear mixed model, differential expression with age was identified in PCF11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCK2 (phosphoenolpyruvate carboxykinase 2 (mitochondrial)) | Using a linear mixed model, differential expression with age was identified in PCK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCM1 (pericentriolar material 1) | Using a linear mixed model, differential expression with age was identified in PCM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCM1 (pericentriolar material 1) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PCNXL4 (pecanex-like 4 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in PCNXL4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCP4 (Purkinje cell protein 4) | Using a linear mixed model, differential expression with age was identified in PCP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pcp4l1 (Purkinje cell protein 4-like 1) | Male and Female | 2 | 26 | Lung | 3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PCTK1 (PCTAIRE protein kinase 1) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PCTK2 (PCTAIRE protein kinase 2) | Male and Female | 26 | 106 | Brain | -19.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PCTP (phosphatidylcholine transfer protein) | Using a linear mixed model, differential expression with age was identified in PCTP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PCYOX1 (prenylcysteine oxidase 1) | Using a linear mixed model, differential expression with age was identified in PCYOX1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDCD1LG2 (programmed cell death 1 ligand 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PDCD1LG2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PDCD4 (programmed cell death 4 (neoplastic transformation inhibitor)) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Pdcd4 (programmed cell death 4) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| PDCD6 (programmed cell death 6) | Gene expression showed a significant (p<E-3) decrease in the expression of PDCD6 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -60.94 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| PDE1B (phosphodiesterase 1B, calmodulin-dependent) | Using a linear mixed model, differential expression with age was identified in PDE1B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pde4b (phosphodiesterase 4B, cAMP specific) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PDE4B (phosphodiesterase 4B, cAMP-specific) | Using a linear mixed model, differential expression with age was identified in PDE4B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDE4C (phosphodiesterase 4C, cAMP-specific) | Using a linear mixed model, differential expression with age was identified in PDE4C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDE4C (phosphodiesterase 4C, cAMP-specific) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of PDE4C and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PDE4D (phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)) | Male and Female | 26 | 106 | Brain | -21.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PDGFC (platelet derived growth factor C) | Using a linear mixed model, differential expression with age was identified in PDGFC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDGFRL (platelet-derived growth factor receptor-like) | Using a linear mixed model, differential expression with age was identified in PDGFRL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDHA1 (pyruvate dehydrogenase (lipoamide) alpha 1) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PDHB (pyruvate dehydrogenase (lipoamide) beta) | Using a linear mixed model, differential expression with age was identified in PDHB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDHB (pyruvate dehydrogenase (lipoamide) beta) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PDHX (pyruvate dehydrogenase complex, component X) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Pdk4 (pyruvate dehydrogenase kinase, isoenzyme 4) | Male and Female | 2 | 15 | Hippocampus | 6.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| PDLIM2 (PDZ and LIM domain 2 (mystique)) | Comparison of DNA methylation showed a significantly decreased methylation level of PDLIM2 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PDLIM2 (PDZ and LIM domain 2 (mystique)) | Comparison of DNA methylation showed a significantly increased methylation level of PDLIM2 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 43.9 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PDLIM3 (PDZ and LIM domain 3) | Male and Female | 26 | 106 | Brain | 22.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PDPN (podoplanin) | Using a linear mixed model, differential expression with age was identified in PDPN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PDXK (pyridoxal (pyridoxine, vitamin B6) kinase) | Comparison of DNA methylation showed a significantly increased methylation level of PDXK in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 17.2 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PDZK1IP1 (PDZK1 interacting protein 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PDZK1IP1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PDZRN3 (PDZ domain containing ring finger 3) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PECR (peroxisomal trans-2-enoyl-CoA reductase) | Using a linear mixed model, differential expression with age was identified in PECR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Peli1 (pellino 1) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| PEPD (peptidase D) | Using a linear mixed model, differential expression with age was identified in PEPD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PER3 (period circadian clock 3) | Using a linear mixed model, differential expression with age was identified in PER3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pes1 (pescadillo homolog 1, containing BRCT domain (zebrafish)) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PEX11A (peroxisomal biogenesis factor 11 alpha) | Using a linear mixed model, differential expression with age was identified in PEX11A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PEX11B (peroxisomal biogenesis factor 11 beta) | Using a linear mixed model, differential expression with age was identified in PEX11B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PEX16 (peroxisomal biogenesis factor 16) | Using a linear mixed model, differential expression with age was identified in PEX16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) | Using a linear mixed model, differential expression with age was identified in PFKFB4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PFN2 (profilin 2) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Pgam2 (phosphoglycerate mutase 2) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PGAM5 (phosphoglycerate mutase family member 5) | Using a linear mixed model, differential expression with age was identified in PGAM5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PGBD5 (piggyBac transposable element derived 5) | Using a linear mixed model, differential expression with age was identified in PGBD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pgf (placental growth factor) | Male and Female | 5 | 22 | Brain | -42.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| PGLS (6-phosphogluconolactonase) | Using a linear mixed model, differential expression with age was identified in PGLS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pglyrp1 (peptidoglycan recognition protein 1) | Male and Female | 2 | 15 | Hippocampus | 8.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| PGM1 (phosphoglucomutase 1) | Using a linear mixed model, differential expression with age was identified in PGM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PGM3 (phosphoglucomutase 3) | Using a linear mixed model, differential expression with age was identified in PGM3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PGP (phosphoglycolate phosphatase) | Using a linear mixed model, differential expression with age was identified in PGP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PGRMC1 (progesterone receptor membrane component 1) | Using a linear mixed model, differential expression with age was identified in PGRMC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PHACTR3 (phosphatase and actin regulator 3) | Using a linear mixed model, differential expression with age was identified in PHACTR3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Phb (prohibitin) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PHF12 (PHD finger protein 12) | Using a linear mixed model, differential expression with age was identified in PHF12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Phf13 (PHD finger protein 13) | Male and Female | 5 | 25 | Skeletal Muscle | -5.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Phf16 (PHD finger protein 16) | Male and Female | 2 | 26 | Lung | -7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PHF21A (PHD finger protein 21A) | Using a linear mixed model, differential expression with age was identified in PHF21A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PHF3 (PHD finger protein 3) | Gene expression showed a significant (p<E-3) decrease in the expression of PHF3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -69.33 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| PHF7 (PHD finger protein 7) | Using a linear mixed model, differential expression with age was identified in PHF7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PHLDA2 (pleckstrin homology-like domain, family A, member 2) | Using a linear mixed model, differential expression with age was identified in PHLDA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PHLDB1 (pleckstrin homology-like domain, family B, member 1) | Using a linear mixed model, differential expression with age was identified in PHLDB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Phldb2 (pleckstrin homology-like domain, family B, member 2) | Male and Female | 3 | 23 | Hematological System | -8.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Phpt1 (phosphohistidine phosphatase 1) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PIANP (PILR alpha associated neural protein) | Using a linear mixed model, differential expression with age was identified in PIANP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIAS1 (protein inhibitor of activated STAT, 1) | Using a linear mixed model, differential expression with age was identified in PIAS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIAS2 (protein inhibitor of activated STAT, 2) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PIAS3 (protein inhibitor of activated STAT, 3) | Using a linear mixed model, differential expression with age was identified in PIAS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIAS3 (protein inhibitor of activated STAT, 3) | Male and Female | 26 | 106 | Brain | 10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PIEZO2 (piezo-type mechanosensitive ion channel component 2) | Using a linear mixed model, differential expression with age was identified in PIEZO2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIGC (phosphatidylinositol glycan anchor biosynthesis, class C) | Using a linear mixed model, differential expression with age was identified in PIGC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIGC (phosphatidylinositol glycan anchor biosynthesis, class C) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PIGL (phosphatidylinositol glycan anchor biosynthesis, class L) | Using a linear mixed model, differential expression with age was identified in PIGL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PIGN (phosphatidylinositol glycan anchor biosynthesis, class N) | Using a linear mixed model, differential expression with age was identified in PIGN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PILRB (paired immunoglobin-like type 2 receptor beta) | Using a linear mixed model, differential expression with age was identified in PILRB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PILRB (paired immunoglobin-like type 2 receptor beta) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PIPOX (pipecolic acid oxidase) | Comparison of DNA methylation showed a significantly increased methylation level of PIPOX in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 22.8 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PIPOX (pipecolic acid oxidase) | Comparison of DNA methylation showed a significantly increased methylation level of PIPOX in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 32.2 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PIPOX (pipecolic acid oxidase) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PIPOX (pipecolic acid oxidase) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PIPOX (pipecolic acid oxidase) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PIPOX (pipecolic acid oxidase) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PISD (phosphatidylserine decarboxylase) | Using a linear mixed model, differential expression with age was identified in PISD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pisd-ps3 (phosphatidylserine decarboxylase, pseudogene 3) | Male and Female | 2 | 26 | Lung | 9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PITPNA (phosphatidylinositol transfer protein, alpha) | Gene expression showed a significant (p<E-3) increase in the expression of PITPNA in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 75.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| PITPNB (phosphatidylinositol transfer protein, beta) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PITPNC1 (phosphatidylinositol transfer protein, cytoplasmic 1) | Using a linear mixed model, differential expression with age was identified in PITPNC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pitx2 (paired-like homeodomain transcription factor 2) | Male and Female | 3 | 23 | Hematological System | -17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| PIWIL2 (piwi-like RNA-mediated gene silencing 2) | Using a linear mixed model, differential expression with age was identified in PIWIL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PKLR (pyruvate kinase, liver and RBC) | Using a linear mixed model, differential expression with age was identified in PKLR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pkm2 (pyruvate kinase, muscle) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PKN1 (protein kinase N1) | Comparison of DNA methylation showed a significantly increased methylation level of PKN1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 17.6 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PKN1 (protein kinase N1) | Comparison of DNA methylation showed a significantly increased methylation level of PKN1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 27.7 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Pkp2 (plakophilin 2) | Male and Female | 5 | 25 | Skeletal Muscle | 12.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| PLA1A (phospholipase A1 member A) | Using a linear mixed model, differential expression with age was identified in PLA1A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLA2G12A (phospholipase A2, group XIIA) | Male and Female | 20 | 75 | Skeletal Muscle | -8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PLA2G4B (phospholipase A2, group IVB (cytosolic)) | Using a linear mixed model, differential expression with age was identified in PLA2G4B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLA2G7 (phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)) | Using a linear mixed model, differential expression with age was identified in PLA2G7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Plac9 (placenta specific 9) | Male and Female | 8 | 24 | Muscle | -7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PLAU (plasminogen activator, urokinase) | Using a linear mixed model, differential expression with age was identified in PLAU in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLCH2 (phospholipase C, eta 2) | Using a linear mixed model, differential expression with age was identified in PLCH2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLCL2 (phospholipase C-like 2) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PLD3 (phospholipase D family, member 3) | Using a linear mixed model, differential expression with age was identified in PLD3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLD3 (phospholipase D family, member 3) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PLEK (pleckstrin) | Using a linear mixed model, differential expression with age was identified in PLEK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Plek (pleckstrin) | Male and Female | 2 | 26 | Lung | 13.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PLEK2 (pleckstrin 2) | Using a linear mixed model, differential expression with age was identified in PLEK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLEKHH3 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 3) | Using a linear mixed model, differential expression with age was identified in PLEKHH3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLEKHS1 (pleckstrin homology domain containing, family S member 1) | Using a linear mixed model, differential expression with age was identified in PLEKHS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLIN2 (perilipin 2) | Using a linear mixed model, differential expression with age was identified in PLIN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Plin4 (perilipin 4) | Male and Female | 6 | 22 | Liver | -29.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Plk1s1 (polo-like kinase 1 substrate 1) | Male and Female | 5 | 22 | Brain | 7.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| PLLP (plasmolipin) | Using a linear mixed model, differential expression with age was identified in PLLP in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLOD1 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1) | Using a linear mixed model, differential expression with age was identified in PLOD1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) | Male and Female | 26 | 106 | Brain | 24.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PLXNA3 (plexin A3) | Using a linear mixed model, differential expression with age was identified in PLXNA3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PLXNB1 (plexin B1) | Male and Female | 26 | 106 | Brain | 11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PM20D1 (peptidase M20 domain containing 1) | Using a linear mixed model, differential expression with age was identified in PM20D1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PM20D1 (peptidase M20 domain containing 1) | Using a linear mixed model, differential expression with age was identified in PM20D1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PMEPA1 (prostate transmembrane protein, androgen induced 1) | Comparison of DNA methylation showed a significantly decreased methylation level of PMEPA1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -20.8 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Pmp22 (peripheral myelin protein 22) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PMP22 (peripheral myelin protein 22) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PMPCA (peptidase (mitochondrial processing) alpha) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PMVK (phosphomevalonate kinase) | Using a linear mixed model, differential expression with age was identified in PMVK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PNCK (pregnancy up-regulated nonubiquitous CaM kinase) | Using a linear mixed model, differential expression with age was identified in PNCK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PNLIPRP3 (pancreatic lipase-related protein 3) | Using a linear mixed model, differential expression with age was identified in PNLIPRP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PNMAL1 (paraneoplastic Ma antigen family-like 1) | Using a linear mixed model, differential expression with age was identified in PNMAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PNMAL2 (paraneoplastic Ma antigen family-like 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PNMAL2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PNN (pinin, desmosome associated protein) | Using a linear mixed model, differential expression with age was identified in PNN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pnp (purine-nucleoside phosphorylase) | Male and Female | 5 | 25 | Skeletal Muscle | 8.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| PNPLA3 (patatin-like phospholipase domain containing 3) | Using a linear mixed model, differential expression with age was identified in PNPLA3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PNPLA5 (patatin-like phospholipase domain containing 5) | Using a linear mixed model, differential expression with age was identified in PNPLA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PODXL (podocalyxin-like) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PODXL and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| POGLUT1 (protein O-glucosyltransferase 1) | Using a linear mixed model, differential expression with age was identified in POGLUT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POGLUT1 (protein O-glucosyltransferase 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of POGLUT1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POLD4 (polymerase (DNA-directed), delta 4, accessory subunit) | Using a linear mixed model, differential expression with age was identified in POLD4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLDIP3 (polymerase (DNA-directed), delta interacting protein 3) | Male and Female | 22 | 73 | Skeletal Muscle | 5.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| POLE4 (polymerase (DNA-directed), epsilon 4, accessory subunit) | Using a linear mixed model, differential expression with age was identified in POLE4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLR1C (polymerase (RNA) I polypeptide C, 30kDa) | Using a linear mixed model, differential expression with age was identified in POLR1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Polr2b (polymerase (RNA) II (DNA directed) polypeptide B) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| POLR2H (polymerase (RNA) II (DNA directed) polypeptide H) | Using a linear mixed model, differential expression with age was identified in POLR2H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POLR3GL (polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like) | Using a linear mixed model, differential expression with age was identified in POLR3GL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of POMGNT1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POMGNT2 (protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)) | Using a linear mixed model, differential expression with age was identified in POMGNT2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PON3 (paraoxonase 3) | Using a linear mixed model, differential expression with age was identified in PON3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PON3 (paraoxonase 3) | Male and Female | 27 | 92 | Kidney | -13.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| POPDC2 (popeye domain containing 2) | Using a linear mixed model, differential expression with age was identified in POPDC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Postn (periostin, osteoblast specific factor) | Male and Female | 3 | 23 | Hematological System | -39.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| POU3F1 (POU class 3 homeobox 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of POU3F1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| POU4F3 (POU class 4 homeobox 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of POU4F3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| POU6F1 (POU class 6 homeobox 1) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PPARG (peroxisome proliferator-activated receptor gamma) | Using a linear mixed model, differential expression with age was identified in PPARG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ppbp (pro-platelet basic protein) | Male and Female | 2 | 26 | Lung | 11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Ppbp (pro-platelet basic protein) | Male and Female | 3 | 23 | Hematological System | -27.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Ppcdc (phosphopantothenoylcysteine decarboxylase) | Male and Female | 4 | 15 | Cochlea | 6.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| PPCS (phosphopantothenoylcysteine synthetase) | Using a linear mixed model, differential expression with age was identified in PPCS in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPIA (peptidylprolyl isomerase A (cyclophilin A)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIA (peptidylprolyl isomerase A (cyclophilin A)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIC (peptidylprolyl isomerase C (cyclophilin C)) | Using a linear mixed model, differential expression with age was identified in PPIC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPIC (peptidylprolyl isomerase C (cyclophilin C)) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIF (peptidylprolyl isomerase F) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PPIG (peptidylprolyl isomerase G (cyclophilin G)) | Using a linear mixed model, differential expression with age was identified in PPIG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPM1E (protein phosphatase 1E (PP2C domain containing)) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PPM1H (protein phosphatase, Mg2+/Mn2+ dependent, 1H) | Using a linear mixed model, differential expression with age was identified in PPM1H in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPM1J (protein phosphatase, Mg2+/Mn2+ dependent, 1J) | Using a linear mixed model, differential expression with age was identified in PPM1J in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP1R11 (protein phosphatase 1, regulatory (inhibitor) subunit 11) | Using a linear mixed model, differential expression with age was identified in PPP1R11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ppp1r14a (protein phosphatase 1, regulatory (inhibitor) subunit 14A) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PPP1R21 (protein phosphatase 1, regulatory subunit 21) | Using a linear mixed model, differential expression with age was identified in PPP1R21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP1R35 (protein phosphatase 1, regulatory subunit 35) | Using a linear mixed model, differential expression with age was identified in PPP1R35 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP1R36 (protein phosphatase 1, regulatory subunit 36) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of PPP1R36 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PPP2R1A (protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PPP2R1B (protein phosphatase 2, regulatory subunit A, beta) | Using a linear mixed model, differential expression with age was identified in PPP2R1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP2R2B (protein phosphatase 2, regulatory subunit B, beta) | Using a linear mixed model, differential expression with age was identified in PPP2R2B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4) | Using a linear mixed model, differential expression with age was identified in PPP2R4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPP5C (protein phosphatase 5, catalytic subunit) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PPT2 (palmitoyl-protein thioesterase 2) | Using a linear mixed model, differential expression with age was identified in PPT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1) | Using a linear mixed model, differential expression with age was identified in PPWD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Pramef8 (PRAME family member 8) | Male and Female | 2 | 26 | Lung | 2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PRCP (prolylcarboxypeptidase (angiotensinase C)) | Using a linear mixed model, differential expression with age was identified in PRCP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRDX6 (peroxiredoxin 6) | Male and Female | 26 | 106 | Brain | 11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PRELP (proline/arginine-rich end leucine-rich repeat protein) | Using a linear mixed model, differential expression with age was identified in PRELP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRKAA1 (protein kinase, AMP-activated, alpha 1 catalytic subunit) | Using a linear mixed model, differential expression with age was identified in PRKAA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRKAA2 (protein kinase, AMP-activated, alpha 2 catalytic subunit) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PRKAG3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit) | Comparison of DNA methylation showed a significantly decreased methylation level of PRKAG3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.8 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PRKAG3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit) | Comparison of DNA methylation showed a significantly decreased methylation level of PRKAG3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -20.1 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) | |
| PRKAG3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit) | Comparison of DNA methylation showed a significantly decreased methylation level of PRKAG3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -15.1 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| PRKAG3 (protein kinase, AMP-activated, gamma 3 non-catalytic subunit) | Comparison of DNA methylation showed a significantly decreased methylation level of PRKAG3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -20.1 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Prkar2b (protein kinase, cAMP dependent regulatory, type II beta) | Male and Female | 2 | 26 | Lung | 10.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PRKCB (protein kinase C, beta) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PRKCDBP (protein kinase C, delta binding protein) | Using a linear mixed model, differential expression with age was identified in PRKCDBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRKCG (protein kinase C, gamma) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PRKCZ (protein kinase C, zeta) | Male and Female | 26 | 106 | Brain | -12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PRKG2 (protein kinase, cGMP-dependent, type II) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PRKG2 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Prkrir (protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repr) | Male and Female | 5 | 25 | Skeletal Muscle | -5.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| PRMT2 (protein arginine methyltransferase 2) | Using a linear mixed model, differential expression with age was identified in PRMT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRNP (prion protein) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PROCR (protein C receptor, endothelial) | Using a linear mixed model, differential expression with age was identified in PROCR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Prodh (proline dehydrogenase) | Male and Female | 2 | 26 | Lung | 5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PRPF3 (pre-mRNA processing factor 3) | Using a linear mixed model, differential expression with age was identified in PRPF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Prpf38a (PRP38 pre-mRNA processing factor 38 (yeast) domain containing A) | Male and Female | 5 | 22 | Brain | 2.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| PRPF40A (PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in PRPF40A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Prpf6 (PRP6 pre-mRNA splicing factor 6 homolog (yeast)) | Male and Female | 5 | 30 | Anatomical System | -1.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| PRPF8 (PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PRR14 (proline rich 14) | Using a linear mixed model, differential expression with age was identified in PRR14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRR34 (proline rich 34) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PRR34 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PRR4 (proline rich 4 (lacrimal)) | Using a linear mixed model, differential expression with age was identified in PRR4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRR5L (proline rich 5 like) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of PRR5L and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PRRG1 (proline rich Gla (G-carboxyglutamic acid) 1) | Using a linear mixed model, differential expression with age was identified in PRRG1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRRX1 (paired related homeobox 1) | Using a linear mixed model, differential expression with age was identified in PRRX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PRUNE2 (prune homolog 2 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in PRUNE2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Psmb10 (proteasome (prosome, macropain) subunit, beta type 10) | Male and Female | 6 | 22 | Liver | 6.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| PSMB2 (proteasome (prosome, macropain) subunit, beta type, 2) | Using a linear mixed model, differential expression with age was identified in PSMB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PSMB5 (proteasome (prosome, macropain) subunit, beta type, 5) | Using a linear mixed model, differential expression with age was identified in PSMB5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PSMB6 (proteasome (prosome, macropain) subunit, beta type, 6) | Using a linear mixed model, differential expression with age was identified in PSMB6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PSMC5 (proteasome (prosome, macropain) 26S subunit, ATPase, 5) | Using a linear mixed model, differential expression with age was identified in PSMC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PSMD8 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 8) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Psme1 (proteasome (prosome, macropain) 28 subunit, alpha) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PSME1 (proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PSME1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PSME3 (proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)) | Using a linear mixed model, differential expression with age was identified in PSME3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PSPC1 (paraspeckle component 1) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2) | Using a linear mixed model, differential expression with age was identified in PSTPIP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTCHD1 (patched domain containing 1) | Using a linear mixed model, differential expression with age was identified in PTCHD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTDSS1 (phosphatidylserine synthase 1) | Using a linear mixed model, differential expression with age was identified in PTDSS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTGDS (prostaglandin D2 synthase 21kDa (brain)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of PTGDS and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| PTGER3 (prostaglandin E receptor 3 (subtype EP3)) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PTGER3 (prostaglandin E receptor 3 (subtype EP3)) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PTGER3 (prostaglandin E receptor 3 (subtype EP3)) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PTGER3 (prostaglandin E receptor 3 (subtype EP3)) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| PTHLH (parathyroid hormone-like hormone) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of PTHLH and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| Ptk2b (PTK2 protein tyrosine kinase 2 beta) | Male and Female | 2 | 26 | Lung | 9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| PTMS (parathymosin) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of PTMS and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PTPN3 (protein tyrosine phosphatase, non-receptor type 3) | Using a linear mixed model, differential expression with age was identified in PTPN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTPN3 (protein tyrosine phosphatase, non-receptor type 3) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PTPRE (protein tyrosine phosphatase, receptor type, E) | Using a linear mixed model, differential expression with age was identified in PTPRE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTPRE (protein tyrosine phosphatase, receptor type, E) | Male and Female | 26 | 106 | Brain | -39.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PTPRJ (protein tyrosine phosphatase, receptor type, J) | Male and Female | 20 | 75 | Skeletal Muscle | 11.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ptpro (protein tyrosine phosphatase, receptor type, O) | Male and Female | 2 | 15 | Hippocampus | -5.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Ptprr (protein tyrosine phosphatase, receptor type, R) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| PTPRT (protein tyrosine phosphatase, receptor type, T) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of PTPRT and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| PTPRZ1 (protein tyrosine phosphatase, receptor-type, Z polypeptide 1) | Using a linear mixed model, differential expression with age was identified in PTPRZ1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PTS (6-pyruvoyltetrahydropterin synthase) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PUSL1 (pseudouridylate synthase-like 1) | Using a linear mixed model, differential expression with age was identified in PUSL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PVRL2 (poliovirus receptor-related 2 (herpesvirus entry mediator B)) | Using a linear mixed model, differential expression with age was identified in PVRL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PVRL3 (poliovirus receptor-related 3) | Male and Female | 26 | 106 | Brain | -20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| PXDNL (peroxidasin homolog (Drosophila)-like) | Male and Female | 20 | 75 | Skeletal Muscle | 20.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| PXMP4 (peroxisomal membrane protein 4, 24kDa) | Using a linear mixed model, differential expression with age was identified in PXMP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| PYCR2 (pyrroline-5-carboxylate reductase family, member 2) | Using a linear mixed model, differential expression with age was identified in PYCR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| QKI (quaking homolog, KH domain RNA binding (mouse)) | Male and Female | 26 | 106 | Brain | 8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| QPRT (quinolinate phosphoribosyltransferase) | Using a linear mixed model, differential expression with age was identified in QPRT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Qrsl1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1) | Male and Female | 2 | 15 | Hippocampus | -3.0 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | ||
| QTRT1 (queuine tRNA-ribosyltransferase 1) | Using a linear mixed model, differential expression with age was identified in QTRT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB10 (RAB10, member RAS oncogene family) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RAB11A (RAB11A, member RAS oncogene family) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RAB11FIP5 (RAB11 family interacting protein 5 (class I)) | Using a linear mixed model, differential expression with age was identified in RAB11FIP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB26 (RAB26, member RAS oncogene family) | Using a linear mixed model, differential expression with age was identified in RAB26 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB2A (RAB2A, member RAS oncogene family) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RAB2B (RAB2B, member RAS oncogene family) | Using a linear mixed model, differential expression with age was identified in RAB2B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB31 (RAB31, member RAS oncogene family) | Using a linear mixed model, differential expression with age was identified in RAB31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB32 (RAB32, member RAS oncogene family) | Using a linear mixed model, differential expression with age was identified in RAB32 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB36 (RAB36, member RAS oncogene family) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of RAB36 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| RAB38 (RAB38, member RAS oncogene family) | Using a linear mixed model, differential expression with age was identified in RAB38 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAB3A (RAB3A, member RAS oncogene family) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RAB3IL1 (RAB3A interacting protein (rabin3)-like 1) | Using a linear mixed model, differential expression with age was identified in RAB3IL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rab40b (Rab40b, member RAS oncogene family) | Male and Female | 3 | 23 | Hematological System | 18.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Rab40b (Rab40b, member RAS oncogene family) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RABAC1 (Rab acceptor 1 (prenylated)) | Using a linear mixed model, differential expression with age was identified in RABAC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rabl5 (RAB, member of RAS oncogene family-like 5) | Male and Female | 2 | 26 | Lung | 3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RAC2 (ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)) | Using a linear mixed model, differential expression with age was identified in RAC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rad23b (RAD23b homolog (S. cerevisiae)) | Male and Female | 5 | 30 | Anatomical System | -1.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| Rad51ap1 (RAD51 associated protein 1) | Male and Female | 2 | 26 | Lung | -11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RAD54B (RAD54 homolog B (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in RAD54B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAI1 (retinoic acid induced 1) | Using a linear mixed model, differential expression with age was identified in RAI1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RALB (v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RALGAPA1 (Ral GTPase activating protein, alpha subunit 1 (catalytic)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Ralgapa2 (Ral GTPase activating protein, alpha subunit 2 (catalytic)) | Male and Female | 2 | 26 | Lung | 7.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RALGDS (ral guanine nucleotide dissociation stimulator) | Using a linear mixed model, differential expression with age was identified in RALGDS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RALY (RALY heterogeneous nuclear ribonucleoprotein) | Using a linear mixed model, differential expression with age was identified in RALY in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAMP1 (receptor (G protein-coupled) activity modifying protein 1) | Male and Female | 26 | 106 | Brain | 16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RAN (RAN, member RAS oncogene family) | Gene expression showed a significant (p<E-3) decrease in the expression of RAN in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -40.12 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| RANBP10 (RAN binding protein 10) | Using a linear mixed model, differential expression with age was identified in RANBP10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RANBP3 (RAN binding protein 3) | Using a linear mixed model, differential expression with age was identified in RANBP3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RAP2A (RAP2A, member of RAS oncogene family) | Male and Female | 26 | 106 | Brain | -28.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1) | Using a linear mixed model, differential expression with age was identified in RAPGEF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RARRES1 (retinoic acid receptor responder (tazarotene induced) 1) | Using a linear mixed model, differential expression with age was identified in RARRES1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RARRES2 (retinoic acid receptor responder (tazarotene induced) 2) | Male and Female | 26 | 106 | Brain | 9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RARS2 (arginyl-tRNA synthetase 2, mitochondrial) | Gene expression showed a significant (p<E-3) decrease in the expression of RARS2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -48.72 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| RASA1 (RAS p21 protein activator (GTPase activating protein) 1) | Using a linear mixed model, differential expression with age was identified in RASA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rasd2 (RASD family, member 2) | Male and Female | 8 | 24 | Muscle | 7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RASEF (RAS and EF-hand domain containing) | Using a linear mixed model, differential expression with age was identified in RASEF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) | Male and Female | 26 | 106 | Brain | -22.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RASSF2 (Ras association (RalGDS/AF-6) domain family member 2) | Using a linear mixed model, differential expression with age was identified in RASSF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RASSF2 (Ras association (RalGDS/AF-6) domain family member 2) | Male and Female | 26 | 106 | Brain | 18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RASSF6 (Ras association (RalGDS/AF-6) domain family member 6) | Using a linear mixed model, differential expression with age was identified in RASSF6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBBP5 (retinoblastoma binding protein 5) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RBBP8 (retinoblastoma binding protein 8) | Using a linear mixed model, differential expression with age was identified in RBBP8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM18 (RNA binding motif protein 18) | Using a linear mixed model, differential expression with age was identified in RBM18 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM20 (RNA binding motif protein 20) | Using a linear mixed model, differential expression with age was identified in RBM20 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM25 (RNA binding motif protein 25) | Using a linear mixed model, differential expression with age was identified in RBM25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rbm3 (RNA binding motif protein 3) | Male and Female | 2 | 26 | Lung | -9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Rbm3 (RNA binding motif protein 3) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| RBM33 (RNA binding motif protein 33) | Using a linear mixed model, differential expression with age was identified in RBM33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM38 (RNA binding motif protein 38) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RBM39 (RNA binding motif protein 39) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RBM41 (RNA binding motif protein 41) | Using a linear mixed model, differential expression with age was identified in RBM41 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM5 (RNA binding motif protein 5) | Using a linear mixed model, differential expression with age was identified in RBM5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBM6 (RNA binding motif protein 6) | Using a linear mixed model, differential expression with age was identified in RBM6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RBP1 (retinol binding protein 1, cellular) | Using a linear mixed model, differential expression with age was identified in RBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rbp1 (retinol binding protein 1, cellular) | Male and Female | 6 | 22 | Liver | 33.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| RBP4 (retinol binding protein 4, plasma) | Male and Female | 26 | 106 | Brain | -13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Rcbtb2 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RCCD1 (RCC1 domain containing 1) | Using a linear mixed model, differential expression with age was identified in RCCD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RCN3 (reticulocalbin 3, EF-hand calcium binding domain) | Using a linear mixed model, differential expression with age was identified in RCN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RCOR3 (REST corepressor 3) | Using a linear mixed model, differential expression with age was identified in RCOR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RDH11 (retinol dehydrogenase 11 (all-trans/9-cis/11-cis)) | Using a linear mixed model, differential expression with age was identified in RDH11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RDH5 (retinol dehydrogenase 5 (11-cis/9-cis)) | Using a linear mixed model, differential expression with age was identified in RDH5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RDX (radixin) | Male and Female | 26 | 106 | Brain | 13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| REEP6 (receptor accessory protein 6) | Using a linear mixed model, differential expression with age was identified in REEP6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Reep6 (receptor accessory protein 6) | Male and Female | 6 | 22 | Liver | -5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) | Gene expression showed a significant (p<E-3) increase in the expression of RELA in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 60.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| Rell1 (RELT-like 1) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RELN (reelin) | RELN promoter methylation increase in neocortal of individuals past their puberty (20-30 years) compared with those that had yet to enter the period of maturation (4-8 years). Prepupertal individuals display little or no methylation at RELN promoter. Mean overall methylation exhibits a striking 25-fold increase after puberty. Postpubertal growth in methylation is the result of a mean 18-fold increase in the number of methylated CpG positions (i.e. extend of methylation) and a four-fold rise in mean percentage of methylation at each methylated CpG position. | Male and Female | 4 | 30 | Brain, Cerebral Cortex | 2962: Lintas and Persico (2010) "Neocortical RELN promoter methylation increases significantly after puberty." Neuroreport 21(2):114-118 (19952965) | ||
| Rem1 (rad and gem related GTP binding protein 1) | Male and Female | 8 | 24 | Muscle | -17.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| REPS2 (RALBP1 associated Eps domain containing 2) | Using a linear mixed model, differential expression with age was identified in REPS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RET (ret proto-oncogene) | Using a linear mixed model, differential expression with age was identified in RET in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| REXO2 (RNA exonuclease 2) | Using a linear mixed model, differential expression with age was identified in REXO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RFC4 (replication factor C (activator 1) 4, 37kDa) | Using a linear mixed model, differential expression with age was identified in RFC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rfc5 (replication factor C (activator 1) 5) | Male and Female | 5 | 25 | Skeletal Muscle | -13.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| RFC5 (replication factor C (activator 1) 5, 36.5kDa) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Rftn2 (raftlin family member 2) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RGMA (repulsive guidance molecule family member a) | Using a linear mixed model, differential expression with age was identified in RGMA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RGN (regucalcin (senescence marker protein-30)) | Male and Female | 26 | 106 | Brain | 15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RGPD5 (RANBP2-like and GRIP domain containing 5) | Comparison of DNA methylation showed a significantly decreased methylation level of RGPD5 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -20.4 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| RGS12 (regulator of G-protein signaling 12) | Using a linear mixed model, differential expression with age was identified in RGS12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rgs18 (regulator of G-protein signaling 18) | Male and Female | 2 | 26 | Lung | 18.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RGS20 (regulator of G-protein signaling 20) | Male and Female | 26 | 106 | Brain | 25.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RGS4 (regulator of G-protein signaling 4) | Male and Female | 26 | 106 | Brain | -16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RGS9BP (regulator of G protein signaling 9 binding protein) | Using a linear mixed model, differential expression with age was identified in RGS9BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RHBDD1 (rhomboid domain containing 1) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| RHBDD1 (rhomboid domain containing 1) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| RHBDD1 (rhomboid domain containing 1) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| RHBDD1 (rhomboid domain containing 1) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| RHBG (Rh family, B glycoprotein (gene/pseudogene)) | Using a linear mixed model, differential expression with age was identified in RHBG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RHCG (Rh family, C glycoprotein) | Male and Female | 27 | 92 | Kidney | -16.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Rhob (ras homolog gene family, member B) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| RHOBTB3 (Rho-related BTB domain containing 3) | Male and Female | 26 | 106 | Brain | 25.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RHOG (ras homolog family member G) | Using a linear mixed model, differential expression with age was identified in RHOG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RICTOR (RPTOR independent companion of MTOR, complex 2) | Gene expression showed a significant (p<E-3) decrease in the expression of RICTOR in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -35.06 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| RIMBP2 (RIMS binding protein 2) | Using a linear mixed model, differential expression with age was identified in RIMBP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RIMS4 (regulating synaptic membrane exocytosis 4) | Using a linear mixed model, differential expression with age was identified in RIMS4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rin2 (Ras and Rab interactor 2) | Male and Female | 2 | 15 | Hippocampus | 7.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| RMDN3 (regulator of microtubule dynamics 3) | Using a linear mixed model, differential expression with age was identified in RMDN3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RMI2 (RecQ mediated genome instability 2) | Using a linear mixed model, differential expression with age was identified in RMI2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RMND5B (required for meiotic nuclear division 5 homolog B (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in RMND5B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RNASE1 (ribonuclease, RNase A family, 1 (pancreatic)) | Using a linear mixed model, differential expression with age was identified in RNASE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RNASE6 (ribonuclease, RNase A family, k6) | Using a linear mixed model, differential expression with age was identified in RNASE6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RNASEK (ribonuclease, RNase K) | Using a linear mixed model, differential expression with age was identified in RNASEK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RND1 (Rho family GTPase 1) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RNF103 (ring finger protein 103) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RNF144B (ring finger protein 144B) | Using a linear mixed model, differential expression with age was identified in RNF144B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RNF144B (ring finger protein 144B) | Gene expression showed a significant (p<E-3) decrease in the expression of RNF144B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -70.24 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| Rnf187 (ring finger protein 187) | Male and Female | 8 | 24 | Muscle | 3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RNF19B (ring finger protein 19B) | Male and Female | 26 | 106 | Brain | -11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Rnf6 (ring finger protein (C3H2C3 type) 6) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RNLS (renalase, FAD-dependent amine oxidase) | Using a linear mixed model, differential expression with age was identified in RNLS in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RORA (RAR-related orphan receptor A) | Using a linear mixed model, differential expression with age was identified in RORA in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase) | Using a linear mixed model, differential expression with age was identified in ROS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RPL29 (ribosomal protein L29) | Using a linear mixed model, differential expression with age was identified in RPL29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RPL3 (ribosomal protein L3) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RPL37 (ribosomal protein L37) | Using a linear mixed model, differential expression with age was identified in RPL37 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rpl37 (ribosomal protein L37) | Male and Female | 6 | 22 | Liver | 4.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Rpl3l (ribosomal protein L3-like) | Male and Female | 8 | 24 | Muscle | -4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| RPN1 (ribophorin I) | Using a linear mixed model, differential expression with age was identified in RPN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RPP25 (ribonuclease P/MRP 25kDa subunit) | Using a linear mixed model, differential expression with age was identified in RPP25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Rprd1b (regulation of nuclear pre-mRNA domain containing 1B) | Male and Female | 6 | 22 | Liver | 10.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| RPS27L (ribosomal protein S27-like) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RPS29 (ribosomal protein S29) | Using a linear mixed model, differential expression with age was identified in RPS29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RPS6KA2 (ribosomal protein S6 kinase, 90kDa, polypeptide 2) | Using a linear mixed model, differential expression with age was identified in RPS6KA2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RRAGD (Ras-related GTP binding D) | Male and Female | 27 | 92 | Kidney | -14.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Rrbp1 (ribosome binding protein 1) | Male and Female | 6 | 22 | Liver | 6.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Rrm2 (ribonucleotide reductase M2) | Male and Female | 2 | 15 | Hippocampus | -14.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Rrp1 (ribosomal RNA processing 1 homolog (S. cerevisiae)) | Male and Female | 5 | 25 | Skeletal Muscle | 5.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| RSPO1 (R-spondin 1) | Using a linear mixed model, differential expression with age was identified in RSPO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RSRP1 (arginine/serine-rich protein 1) | Using a linear mixed model, differential expression with age was identified in C1orf63 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RTCD1 (RNA terminal phosphate cyclase domain 1) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| RTDR1 (rhabdoid tumor deletion region gene 1) | Using a linear mixed model, differential expression with age was identified in RTDR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RTN1 (reticulon 1) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RTN4 (reticulon 4) | Using a linear mixed model, differential expression with age was identified in RTN4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RTN4 (reticulon 4) | Male and Female | 26 | 106 | Brain | -8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| RUFY3 (RUN and FYVE domain containing 3) | Using a linear mixed model, differential expression with age was identified in RUFY3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RUNDC3A (RUN domain containing 3A) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Runx1t1 (runt-related transcription factor 1; translocated to, 1 (cyclin D-related)) | Male and Female | 3 | 23 | Hematological System | 17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| RWDD2A (RWD domain containing 2A) | Using a linear mixed model, differential expression with age was identified in RWDD2A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RXRA (retinoid X receptor, alpha) | Using a linear mixed model, differential expression with age was identified in RXRA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RXRG (retinoid X receptor, gamma) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Rybp (RING1 and YY1 binding protein) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| RYK (receptor-like tyrosine kinase) | Using a linear mixed model, differential expression with age was identified in RYK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| RYR1 (ryanodine receptor 1 (skeletal)) | Using a linear mixed model, differential expression with age was identified in RYR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ryr1 (ryanodine receptor 1, skeletal muscle) | Male and Female | 5 | 30 | Anatomical System | -9.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| RYR2 (ryanodine receptor 2 (cardiac)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of RYR2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| RYR3 (ryanodine receptor 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of RYR3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| S100A3 (S100 calcium binding protein A3) | Using a linear mixed model, differential expression with age was identified in S100A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| S100A4 (S100 calcium binding protein A4) | Using a linear mixed model, differential expression with age was identified in S100A4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| S100a6 (S100 calcium binding protein A6 (calcyclin)) | Male and Female | 2 | 15 | Hippocampus | 4.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| S100a8 (S100 calcium binding protein A8 (calgranulin A)) | Male and Female | 3 | 23 | Hematological System | -40.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| S100A8 (S100 calcium binding protein A8) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe S100A8 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 1228.24 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100A8 (S100 calcium binding protein A8) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe S100A8 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 530.64 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100A8 (S100 calcium binding protein A8) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus S100A8 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 1115.4 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100A8 (S100 calcium binding protein A8) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe S100A8 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 921.38 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100a9 (S100 calcium binding protein A9 (calgranulin B)) | Male and Female | 2 | 15 | Hippocampus | 33.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| S100A9 (S100 calcium binding protein A9) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe S100A9 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 228.96 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100A9 (S100 calcium binding protein A9) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe S100A9 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 92.75 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| S100B (S100 calcium binding protein B) | Male and Female | 26 | 106 | Brain | 11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| S100b (S100 protein, beta polypeptide, neural) | Male and Female | 2 | 15 | Hippocampus | 4.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| S100PBP (S100P binding protein) | Using a linear mixed model, differential expression with age was identified in S100PBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| S1PR1 (sphingosine-1-phosphate receptor 1) | Male and Female | 26 | 106 | Brain | 27.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| S1PR5 (sphingosine-1-phosphate receptor 5) | Using a linear mixed model, differential expression with age was identified in S1PR5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Saa1 (serum amyloid A 1) | Male and Female | 3 | 23 | Hematological System | 118.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SAFB2 (scaffold attachment factor B2) | Using a linear mixed model, differential expression with age was identified in SAFB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SAMD10 (sterile alpha motif domain containing 10) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of SAMD10 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SAMD9L (sterile alpha motif domain containing 9-like) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SAMM50 (sorting and assembly machinery component 50 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in SAMM50 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SAMM50 (sorting and assembly machinery component 50 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Sap30l (SAP30-like) | Male and Female | 5 | 25 | Skeletal Muscle | -4.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| SAPCD1 (suppressor APC domain containing 1) | Using a linear mixed model, differential expression with age was identified in SAPCD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SAR1B (secretion associated, Ras related GTPase 1B) | Using a linear mixed model, differential expression with age was identified in SAR1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SARS (seryl-tRNA synthetase) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SATL1 (spermidine/spermine N1-acetyl transferase-like 1) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SBNO1 (strawberry notch homolog 1 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in SBNO1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SC5D (sterol-C5-desaturase) | Using a linear mixed model, differential expression with age was identified in SC5D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Scamp2 (secretory carrier membrane protein 2) | Male and Female | 5 | 25 | Skeletal Muscle | 4.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| SCAP (SREBF chaperone) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of SCAP and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SCARB1 (scavenger receptor class B, member 1) | Using a linear mixed model, differential expression with age was identified in SCARB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SCCPDH (saccharopine dehydrogenase (putative)) | Gene expression showed a significant (p<E-3) decrease in the expression of SCCPDH in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -46.52 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SCGB3A1 (secretoglobin, family 3A, member 1) | Using a linear mixed model, differential expression with age was identified in SCGB3A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SCGN (secretagogin, EF-hand calcium binding protein) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of SCGN and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SCLY (selenocysteine lyase) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SCMH1 (sex comb on midleg homolog 1 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in SCMH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SCN2B (sodium channel, voltage-gated, type II, beta) | Male and Female | 26 | 106 | Brain | -50.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SCN7A (sodium channel, voltage-gated, type VII, alpha subunit) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of SCN7A and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SCNN1G (sodium channel, non-voltage-gated 1, gamma subunit) | Using a linear mixed model, differential expression with age was identified in SCNN1G in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SCO2 (SCO2 cytochrome c oxidase assembly protein) | Using a linear mixed model, differential expression with age was identified in SCO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Scyl1 (SCY1-like 1 (S. cerevisiae)) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SDC2 (syndecan 2) | Male and Female | 26 | 106 | Brain | 25.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SDCCAG3 (serologically defined colon cancer antigen 3) | Using a linear mixed model, differential expression with age was identified in SDCCAG3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SDF2 (stromal cell-derived factor 2) | Using a linear mixed model, differential expression with age was identified in SDF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SDF2L1 (stromal cell-derived factor 2-like 1) | Using a linear mixed model, differential expression with age was identified in SDF2L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SDS (serine dehydratase) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of SDS and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SDSL (serine dehydratase-like) | Using a linear mixed model, differential expression with age was identified in SDSL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEC14L1 (SEC14-like 1 (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in SEC14L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEC14L4 (SEC14-like 4 (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in SEC14L4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEC22B (SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)) | Using a linear mixed model, differential expression with age was identified in SEC22B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sec61a1 (Sec61 alpha 1 subunit (S. cerevisiae)) | Male and Female | 2 | 15 | Hippocampus | -1.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SECISBP2 (SECIS binding protein 2) | Using a linear mixed model, differential expression with age was identified in SECISBP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Seh1l (SEH1-like (S. cerevisiae) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SEL1L2 (sel-1 suppressor of lin-12-like 2 (C. elegans)) | Using a linear mixed model, differential expression with age was identified in SEL1L2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SELENBP1 (selenium binding protein 1) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SELENBP1 (selenium binding protein 1) | Male and Female | 22 | 73 | Skeletal Muscle | 7.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| SELENBP1 (selenium binding protein 1) | Comparison of DNA methylation showed a significantly decreased methylation level of SELENBP1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -20.8 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SELENBP1 (selenium binding protein 1) | Comparison of DNA methylation showed a significantly decreased methylation level of SELENBP1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.7 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SELL (selectin L) | Using a linear mixed model, differential expression with age was identified in SELL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B) | Comparison of DNA methylation showed a significantly increased methylation level of SEMA3B in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 19.1 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B) | Comparison of DNA methylation showed a significantly increased methylation level of SEMA3B in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 16.1 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SEMA3F (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F) | Using a linear mixed model, differential expression with age was identified in SEMA3F in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEMA4B (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B) | Using a linear mixed model, differential expression with age was identified in SEMA4B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEMA4B (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B) | Gene expression showed a significant (p<E-3) increase in the expression of SEMA4B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 58.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SEMA5B (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) | Using a linear mixed model, differential expression with age was identified in SEMA5B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SEMA6A (sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A) | Male and Female | 26 | 106 | Brain | 8.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SENP3 (SUMO1/sentrin/SMT3 specific peptidase 3) | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Senp6 (SUMO/sentrin specific peptidase 6) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SEPHS1 (selenophosphate synthetase 1) | Male and Female | 26 | 106 | Brain | 12.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SEPP1 (selenoprotein P, plasma, 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SEPT3 (septin 3) | Using a linear mixed model, differential expression with age was identified in SEPT3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sept5 (septin 5) | Male and Female | 3 | 23 | Hematological System | 36.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Sepx1 (selenoprotein X 1) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SERF2 (small EDRK-rich factor 2) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1) | Using a linear mixed model, differential expression with age was identified in SERPINA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SERPINA12 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12) | Comparison of DNA methylation showed a significantly decreased methylation level of SERPINA12 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -15.2 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SERPINA12 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12) | Comparison of DNA methylation showed a significantly increased methylation level of SERPINA12 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 52.7 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3) | Using a linear mixed model, differential expression with age was identified in SERPINA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Serpina3n (serine (or cysteine) peptidase inhibitor, clade A, member 3N) | Male and Female | 2 | 24 | Visual Apparatus | 141.0 | <0.001 | 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767) | |
| SERPINA5 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5) | Using a linear mixed model, differential expression with age was identified in SERPINA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SERPINA5 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5) | Male and Female | 27 | 92 | Kidney | -11.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2) | Using a linear mixed model, differential expression with age was identified in SERPINB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SERPINE2 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2) | Using a linear mixed model, differential expression with age was identified in SERPINE2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Serpinf1 (serine (or cysteine) peptidase inhibitor, clade F, member 1) | Male and Female | 8 | 24 | Muscle | -8.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)) | Using a linear mixed model, differential expression with age was identified in SERPINH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SETDB1 (SET domain, bifurcated 1) | Using a linear mixed model, differential expression with age was identified in SETDB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SETDB2 (SET domain, bifurcated 2) | Using a linear mixed model, differential expression with age was identified in SETDB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SF3B5 (splicing factor 3b, subunit 5, 10kDa) | Using a linear mixed model, differential expression with age was identified in SF3B5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sfi1 (Sfi1 homolog, spindle assembly associated (yeast)) | Male and Female | 2 | 26 | Lung | 10.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SFPQ (splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Sfrs5 (splicing factor, arginine/serine-rich 5 (SRp40, HRS)) | Male and Female | 2 | 15 | Hippocampus | 3.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SFRS5 (splicing factor, arginine/serine-rich 5) | Using a linear mixed model, differential expression with age was identified in SRSF5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SFRS5 (splicing factor, arginine/serine-rich 5) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SFRS6 (splicing factor, arginine/serine-rich 6) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SFSWAP (splicing factor, suppressor of white-apricot family) | Using a linear mixed model, differential expression with age was identified in SFSWAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SFTPC (surfactant protein C) | Using a linear mixed model, differential expression with age was identified in SFTPC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sgca (sarcoglycan, alpha (dystrophin-associated glycoprotein)) | Male and Female | 5 | 25 | Skeletal Muscle | 13.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Sgk1 (serum/glucocorticoid regulated kinase 1) | Male and Female | 2 | 15 | Hippocampus | 9.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SGK2 (serum/glucocorticoid regulated kinase 2) | Using a linear mixed model, differential expression with age was identified in SGK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SGPL1 (sphingosine-1-phosphate lyase 1) | Using a linear mixed model, differential expression with age was identified in SGPL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SGPP2 (sphingosine-1-phosphate phosphatase 2) | Using a linear mixed model, differential expression with age was identified in SGPP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SGSM2 (small G protein signaling modulator 2) | Using a linear mixed model, differential expression with age was identified in SGSM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SH3BGRL3 (SH3 domain binding glutamate-rich protein like 3) | Using a linear mixed model, differential expression with age was identified in SH3BGRL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SH3GLB1 (SH3-domain GRB2-like endophilin B1) | Using a linear mixed model, differential expression with age was identified in SH3GLB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SH3KBP1 (SH3-domain kinase binding protein 1) | Male and Female | 20 | 75 | Skeletal Muscle | -5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SHB (Src homology 2 domain containing adaptor protein B) | Using a linear mixed model, differential expression with age was identified in SHB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SHF (Src homology 2 domain containing F) | Using a linear mixed model, differential expression with age was identified in SHF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SHISA2 (shisa family member 2) | Using a linear mixed model, differential expression with age was identified in SHISA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SHKBP1 (SH3KBP1 binding protein 1) | Using a linear mixed model, differential expression with age was identified in SHKBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SHROOM3 (shroom family member 3) | Using a linear mixed model, differential expression with age was identified in SHROOM3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SIDT2 (SID1 transmembrane family, member 2) | Using a linear mixed model, differential expression with age was identified in SIDT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SIL1 (SIL1 nucleotide exchange factor) | Using a linear mixed model, differential expression with age was identified in SIL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sirt1 (sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)) | Bone marrow stromal cells derived from 15-month-old mice had decreased Sirt1 activity than cells derived from 4-month-old mice. | Male | 0 | 15 | Bone Marrow | 2855: Li et al. (2011) "Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals." J. Bone Miner. Res. 26(11):2656-2664 (21812028) | ||
| SIRT5 (sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SKA2P1 (spindle and kinetochore associated complex subunit 2 pseudogene 1) | Gene expression showed a significant (p<E-3) decrease in the expression of SKA2P1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -36.71 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SKP1 (S-phase kinase-associated protein 1) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SLC10A3 (solute carrier family 10, member 3) | Using a linear mixed model, differential expression with age was identified in SLC10A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC10A4 (solute carrier family 10, member 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of SLC10A4 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SLC11A2 (solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2) | Using a linear mixed model, differential expression with age was identified in SLC11A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC12A3 (solute carrier family 12 (sodium/chloride transporters), member 3) | Male and Female | 27 | 92 | Kidney | -16.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| SLC15A3 (solute carrier family 15 (oligopeptide transporter), member 3) | Using a linear mixed model, differential expression with age was identified in SLC15A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC15A3 (solute carrier family 15 (oligopeptide transporter), member 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of SLC15A3 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SLC16A5 (solute carrier family 16 (monocarboxylate transporter), member 5) | Using a linear mixed model, differential expression with age was identified in SLC16A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC16A9 (solute carrier family 16, member 9) | Using a linear mixed model, differential expression with age was identified in SLC16A9 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc17a3 (solute carrier family 17 (sodium phosphate), member 3) | Male and Female | 5 | 22 | Brain | 11.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| SLC17A7 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7) | Using a linear mixed model, differential expression with age was identified in SLC17A7 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC17A7 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SLC22A17 (solute carrier family 22, member 17) | Using a linear mixed model, differential expression with age was identified in SLC22A17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC22A18 (solute carrier family 22, member 18) | Comparison of DNA methylation showed a significantly increased methylation level of SLC22A18 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 16.9 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SLC25A1 (solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC25A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc25a11 (solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11) | Male and Female | 8 | 24 | Muscle | -1.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SLC25A12 (solute carrier family 25 (mitochondrial carrier, Aralar), member 12) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC25A18 (solute carrier family 25 (glutamate carrier), member 18) | Using a linear mixed model, differential expression with age was identified in SLC25A18 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC25A20 (solute carrier family 25 (carnitine/acylcarnitine translocase), member 20) | Using a linear mixed model, differential expression with age was identified in SLC25A20 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC25A25 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25) | Using a linear mixed model, differential expression with age was identified in SLC25A25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC25A28 (solute carrier family 25 (mitochondrial iron transporter), member 28) | Using a linear mixed model, differential expression with age was identified in SLC25A28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc25a28 (solute carrier family 25, member 28) | Male and Female | 8 | 24 | Muscle | 5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SLC25A3 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC25A30 (solute carrier family 25, member 30) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC25A34 (solute carrier family 25, member 34) | Using a linear mixed model, differential expression with age was identified in SLC25A34 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC25A35 (solute carrier family 25, member 35) | Using a linear mixed model, differential expression with age was identified in SLC25A35 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC25A4 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC25A4 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4) | Male and Female | 26 | 106 | Brain | -9.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SLC25A42 (solute carrier family 25, member 42) | Using a linear mixed model, differential expression with age was identified in SLC25A42 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc25a5 (solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5) | Male and Female | 2 | 15 | Hippocampus | -2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SLC26A10 (solute carrier family 26, member 10) | Using a linear mixed model, differential expression with age was identified in SLC26A10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC26A10 (solute carrier family 26, member 10) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of SLC26A10 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SLC26A3 (solute carrier family 26 (anion exchanger), member 3) | Using a linear mixed model, differential expression with age was identified in SLC26A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC27A2 (solute carrier family 27 (fatty acid transporter), member 2) | Using a linear mixed model, differential expression with age was identified in SLC27A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC27A3 (solute carrier family 27 (fatty acid transporter), member 3) | Using a linear mixed model, differential expression with age was identified in SLC27A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC2A1 (solute carrier family 2 (facilitated glucose transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC2A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC2A1 (solute carrier family 2 (facilitated glucose transporter), member 1) | An age-associated decrease in the activity of glucose transport across the blood brain barrier is thought to be associated with vulnerability to hypoglycemia and cognitive decline. | Male and Female | -1 | -1 | Blood Brain Barrier | 2864: Zeevi et al. (2010) "The blood-brain barrier: geriatric relevance of a critical brain-body interface." J Am Geriatr Soc 58(9):1749-1757 (20863334) | ||
| Slc2a1 (solute carrier family 2 (facilitated glucose transporter), member 1) | Male and Female | 2 | 15 | Hippocampus | 6.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SLC2A3P1 (solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SLC2A5 (solute carrier family 2 (facilitated glucose/fructose transporter), member 5) | Using a linear mixed model, differential expression with age was identified in SLC2A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC30A1 (solute carrier family 30 (zinc transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC30A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC31A2 (solute carrier family 31 (copper transporter), member 2) | Using a linear mixed model, differential expression with age was identified in SLC31A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC35A2 (solute carrier family 35 (UDP-galactose transporter), member A2) | Using a linear mixed model, differential expression with age was identified in SLC35A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc35a2 (solute carrier family 35 (UDP-galactose transporter), member A2) | Male and Female | 8 | 24 | Muscle | -9.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SLC35B1 (solute carrier family 35, member B1) | Using a linear mixed model, differential expression with age was identified in SLC35B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC35F1 (solute carrier family 35, member F1) | Using a linear mixed model, differential expression with age was identified in SLC35F1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC35F2 (solute carrier family 35, member F2) | Using a linear mixed model, differential expression with age was identified in SLC35F2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC35G1 (solute carrier family 35, member G1) | Using a linear mixed model, differential expression with age was identified in SLC35G1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC37A4 (solute carrier family 37 (glucose-6-phosphate transporter), member 4) | Using a linear mixed model, differential expression with age was identified in SLC37A4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC38A1 (solute carrier family 38, member 1) | Male and Female | 20 | 75 | Skeletal Muscle | -7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC38A10 (solute carrier family 38, member 10) | Using a linear mixed model, differential expression with age was identified in SLC38A10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC38A10 (solute carrier family 38, member 10) | Using a linear mixed model, differential expression with age was identified in SLC38A10 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc38a2 (solute carrier family 38, member 2) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SLC39A3 (solute carrier family 39 (zinc transporter), member 3) | Using a linear mixed model, differential expression with age was identified in SLC39A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC41A1 (solute carrier family 41 (magnesium transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC41A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC41A3 (solute carrier family 41, member 3) | Gene expression showed a significant (p<E-3) increase in the expression of SLC41A3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 52.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SLC45A2 (solute carrier family 45, member 2) | Using a linear mixed model, differential expression with age was identified in SLC45A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC45A4 (solute carrier family 45, member 4) | Using a linear mixed model, differential expression with age was identified in SLC45A4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC46A3 (solute carrier family 46, member 3) | Using a linear mixed model, differential expression with age was identified in SLC46A3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC47A1 (solute carrier family 47 (multidrug and toxin extrusion), member 1) | Using a linear mixed model, differential expression with age was identified in SLC47A1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC47A1 (solute carrier family 47 (multidrug and toxin extrusion), member 1) | Using a linear mixed model, differential expression with age was identified in SLC47A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC48A1 (solute carrier family 48 (heme transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC48A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC4A11 (solute carrier family 4, sodium borate transporter, member 11) | Using a linear mixed model, differential expression with age was identified in SLC4A11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC50A1 (solute carrier family 50 (sugar efflux transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC50A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC52A1 (solute carrier family 52 (riboflavin transporter), member 1) | Using a linear mixed model, differential expression with age was identified in SLC52A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC52A2 (solute carrier family 52 (riboflavin transporter), member 2) | Using a linear mixed model, differential expression with age was identified in SLC52A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC52A2 (solute carrier family 52 (riboflavin transporter), member 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of SLC52A2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| SLC5A6 (solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6) | Using a linear mixed model, differential expression with age was identified in SLC5A6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC6A17 (solute carrier family 6 (neutral amino acid transporter), member 17) | Using a linear mixed model, differential expression with age was identified in SLC6A17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) | Male and Female | 2 | 26 | Lung | 16.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SLC6A8 (solute carrier family 6 (neurotransmitter transporter), member 8) | Using a linear mixed model, differential expression with age was identified in SLC6A8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC7A1 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 1) | Using a linear mixed model, differential expression with age was identified in SLC7A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC7A3 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 3) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SLC7A4 (solute carrier family 7, member 4) | Using a linear mixed model, differential expression with age was identified in SLC7A4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC7A5 (solute carrier family 7 (amino acid transporter light chain, L system), member 5) | Using a linear mixed model, differential expression with age was identified in SLC7A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLC7A8 (solute carrier family 7 (amino acid transporter light chain, L system), member 8) | Using a linear mixed model, differential expression with age was identified in SLC7A8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SLC9A9 (solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9) | Using a linear mixed model, differential expression with age was identified in SLC9A9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLCO2B1 (solute carrier organic anion transporter family, member 2B1) | Using a linear mixed model, differential expression with age was identified in SLCO2B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLCO3A1 (solute carrier organic anion transporter family, member 3A1) | Gene expression showed a significant (p<E-3) increase in the expression of SLCO3A1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 92.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| Slco4a1 (solute carrier organic anion transporter family, member 4a1) | Male and Female | 3 | 23 | Hematological System | 17.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SLFN11 (schlafen family member 11) | Male and Female | 0 | 102 | Temporal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| SLFN11 (schlafen family member 11) | Male and Female | 0 | 102 | Pons | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| SLFN11 (schlafen family member 11) | Male and Female | 0 | 102 | Frontal Lobe | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| SLFN11 (schlafen family member 11) | Male and Female | 0 | 102 | Cerebellum | 0.0 | <0.001 | 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877) | |
| SLITRK4 (SLIT and NTRK-like family, member 4) | Using a linear mixed model, differential expression with age was identified in SLITRK4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLMAP (sarcolemma associated protein) | Using a linear mixed model, differential expression with age was identified in SLMAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLMAP (sarcolemma associated protein) | Using a linear mixed model, differential expression with age was identified in SLMAP in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLPI (secretory leukocyte peptidase inhibitor) | Comparison of DNA methylation showed a significantly decreased methylation level of SLPI in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -18.6 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SLTM (SAFB-like, transcription modulator) | Using a linear mixed model, differential expression with age was identified in SLTM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SLTM (SAFB-like, transcription modulator) | Using a linear mixed model, differential expression with age was identified in SLTM in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Slu7 (SLU7 splicing factor homolog (S. cerevisiae)) | Male and Female | 3 | 23 | Hematological System | -5.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Smad1 (MAD homolog 1 (Drosophila)) | Male and Female | 2 | 15 | Hippocampus | 4.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| SMAD2 (SMAD family member 2) | Comparison of DNA methylation showed a significantly increased methylation level of SMAD2 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 16.5 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SMAD2 (SMAD family member 2) | Gene expression showed a significant (p<E-3) decrease in the expression of SMAD2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -57.98 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SMAD3 (SMAD family member 3) | Using a linear mixed model, differential expression with age was identified in SMAD3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMAD7 (SMAD family member 7) | Using a linear mixed model, differential expression with age was identified in SMAD7 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMAGP (small cell adhesion glycoprotein) | Using a linear mixed model, differential expression with age was identified in SMAGP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2) | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) | Using a linear mixed model, differential expression with age was identified in SMARCA4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMARCAD1 (SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1) | Using a linear mixed model, differential expression with age was identified in SMARCAD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMC4 (structural maintenance of chromosomes 4) | Using a linear mixed model, differential expression with age was identified in SMC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMG1 (SMG1 phosphatidylinositol 3-kinase-related kinase) | Using a linear mixed model, differential expression with age was identified in SMG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMIM14 (small integral membrane protein 14) | Gene expression showed a significant (p<E-3) decrease in the expression of C4orf34 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -35.9 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SMOC1 (SPARC related modular calcium binding 1) | Using a linear mixed model, differential expression with age was identified in SMOC1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMOC2 (SPARC related modular calcium binding 2) | Using a linear mixed model, differential expression with age was identified in SMOC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMOX (spermine oxidase) | Using a linear mixed model, differential expression with age was identified in SMOX in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMPD1 (sphingomyelin phosphodiesterase 1, acid lysosomal) | Using a linear mixed model, differential expression with age was identified in SMPD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SMYD2 (SET and MYND domain containing 2) | Using a linear mixed model, differential expression with age was identified in SMYD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNAP23 (synaptosomal-associated protein, 23kDa) | Gene expression showed a significant (p<E-3) decrease in the expression of SNAP23 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -51.46 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SND1 (staphylococcal nuclease and tudor domain containing 1) | Using a linear mixed model, differential expression with age was identified in SND1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Snd1 (staphylococcal nuclease and tudor domain containing 1) | Male and Female | 3 | 23 | Hematological System | -5.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SNN (stannin) | Comparison of DNA methylation showed a significantly increased methylation level of SNN in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 19.5 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SNRK (SNF related kinase) | Using a linear mixed model, differential expression with age was identified in SNRK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNRNP25 (small nuclear ribonucleoprotein 25kDa (U11/U12)) | Using a linear mixed model, differential expression with age was identified in SNRNP25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNRNP70 (small nuclear ribonucleoprotein 70kDa (U1)) | Using a linear mixed model, differential expression with age was identified in SNRNP70 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNRNP70 (small nuclear ribonucleoprotein 70kDa (U1)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Snrpd2 (small nuclear ribonucleoprotein D2) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa) | Using a linear mixed model, differential expression with age was identified in SNRPD3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNTA1 (syntrophin, alpha 1) | Using a linear mixed model, differential expression with age was identified in SNTA1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SNTB1 (syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of SNTB1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| SNTG1 (syntrophin, gamma 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of SNTG1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Snx12 (sorting nexin 12) | Male and Female | 8 | 24 | Muscle | -3.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SNX20 (sorting nexin 20) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of SNX20 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Snx20 (sorting nexin 20) | Male and Female | 8 | 24 | Muscle | -7.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SNX3 (sorting nexin 3) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Snx33 (sorting nexin 33) | Male and Female | 3 | 23 | Hematological System | 62.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SOAT1 (sterol O-acyltransferase 1) | Using a linear mixed model, differential expression with age was identified in SOAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SOD2 (superoxide dismutase 2, mitochondrial) | Using a linear mixed model, differential expression with age was identified in SOD2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SORBS2 (sorbin and SH3 domain containing 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of SORBS2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| SORD (sorbitol dehydrogenase) | Using a linear mixed model, differential expression with age was identified in SORD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SORT1 (sortilin 1) | Using a linear mixed model, differential expression with age was identified in SORT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sos1 (son of sevenless homolog 1 (Drosophila)) | Male and Female | 2 | 26 | Lung | -5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SOWAHC (sosondowah ankyrin repeat domain family member C) | Using a linear mixed model, differential expression with age was identified in SOWAHC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sox10 (SRY-box containing gene 10) | Male and Female | 5 | 30 | Anatomical System | 4.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| SOX15 (SRY (sex determining region Y)-box 15) | Using a linear mixed model, differential expression with age was identified in SOX15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sp110 (Sp110 nuclear body protein) | Male and Female | 3 | 23 | Hematological System | 10.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SPAG7 (sperm associated antigen 7) | Comparison of DNA methylation showed a significantly decreased methylation level of SPAG7 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -26.2 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SPAG7 (sperm associated antigen 7) | Comparison of DNA methylation showed a significantly increased methylation level of SPAG7 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 26.1 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SPAG9 (sperm associated antigen 9) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Spata17 (spermatogenesis associated 17) | Male and Female | 2 | 26 | Lung | 30.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SPATS2 (spermatogenesis associated, serine-rich 2) | Using a linear mixed model, differential expression with age was identified in SPATS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Spats2 (spermatogenesis associated, serine-rich 2) | Male and Female | 3 | 23 | Hematological System | 20.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SPCS3 (signal peptidase complex subunit 3 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in SPCS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPEN (spen family transcriptional repressor) | Using a linear mixed model, differential expression with age was identified in SPEN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPG11 (spastic paraplegia 11 (autosomal recessive)) | Using a linear mixed model, differential expression with age was identified in SPG11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Spg20 (spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)) | Male and Female | 5 | 25 | Skeletal Muscle | 11.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| SPG7 (spastic paraplegia 7 (pure and complicated autosomal recessive)) | Using a linear mixed model, differential expression with age was identified in SPG7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPINT2 (serine peptidase inhibitor, Kunitz type, 2) | Male and Female | 26 | 106 | Brain | -3.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Spint2 (serine protease inhibitor, Kunitz type 2) | Male and Female | 8 | 24 | Muscle | 6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| SPIRE2 (spire-type actin nucleation factor 2) | Using a linear mixed model, differential expression with age was identified in SPIRE2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPOCK1 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1) | Using a linear mixed model, differential expression with age was identified in SPOCK1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPON1 (spondin 1, extracellular matrix protein) | Using a linear mixed model, differential expression with age was identified in SPON1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPON1 (spondin 1, extracellular matrix protein) | Using a linear mixed model, differential expression with age was identified in SPON1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPON1 (spondin 1, extracellular matrix protein) | Male and Female | 26 | 106 | Brain | 21.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SPR (sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)) | Using a linear mixed model, differential expression with age was identified in SPR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPRR1A (small proline-rich protein 1A) | Using a linear mixed model, differential expression with age was identified in SPRR1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPRR4 (small proline-rich protein 4) | Using a linear mixed model, differential expression with age was identified in SPRR4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPRY2 (sprouty homolog 2 (Drosophila)) | Using a linear mixed model, differential expression with age was identified in SPRY2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPRYD4 (SPRY domain containing 4) | Using a linear mixed model, differential expression with age was identified in SPRYD4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPTBN1 (spectrin, beta, non-erythrocytic 1) | Gene expression showed a significant (p<E-3) decrease in the expression of SPTBN1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -48.45 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| SPTBN4 (spectrin, beta, non-erythrocytic 4) | Using a linear mixed model, differential expression with age was identified in SPTBN4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SPTLC3 (serine palmitoyltransferase, long chain base subunit 3) | Using a linear mixed model, differential expression with age was identified in SPTLC3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Sqle (squalene epoxidase) | Male and Female | 6 | 22 | Liver | 26.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| SREBF1 (sterol regulatory element binding transcription factor 1) | Using a linear mixed model, differential expression with age was identified in SREBF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Srgn (serglycin) | Male and Female | 2 | 26 | Lung | 5.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| SRM (spermidine synthase) | Using a linear mixed model, differential expression with age was identified in SRM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SRPK2 (SRSF protein kinase 2) | Using a linear mixed model, differential expression with age was identified in SRPK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SRRM2 (serine/arginine repetitive matrix 2) | Using a linear mixed model, differential expression with age was identified in SRRM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SRRT (serrate, RNA effector molecule) | Using a linear mixed model, differential expression with age was identified in SRRT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SRSF2 (serine/arginine-rich splicing factor 2) | Using a linear mixed model, differential expression with age was identified in SRSF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SRSF4 (serine/arginine-rich splicing factor 4) | Using a linear mixed model, differential expression with age was identified in SRSF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SS18L1 (synovial sarcoma translocation gene on chromosome 18-like 1) | Using a linear mixed model, differential expression with age was identified in SS18L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SSH2 (slingshot protein phosphatase 2) | Using a linear mixed model, differential expression with age was identified in SSH2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SSH3 (slingshot protein phosphatase 3) | Using a linear mixed model, differential expression with age was identified in SSH3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ssrp1 (structure specific recognition protein 1) | Male and Female | 5 | 25 | Skeletal Muscle | -3.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| St3gal3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3) | Male and Female | 6 | 22 | Liver | 25.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5) | Using a linear mixed model, differential expression with age was identified in ST3GAL5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6) | Using a linear mixed model, differential expression with age was identified in ST3GAL6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ST5 (suppression of tumorigenicity 5) | Using a linear mixed model, differential expression with age was identified in ST5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ST6GALNAC2 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ST6GALNAC4 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4) | Using a linear mixed model, differential expression with age was identified in ST6GALNAC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ST6GALNAC6 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6) | Using a linear mixed model, differential expression with age was identified in ST6GALNAC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STAMBP (STAM binding protein) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| STAMBPL1 (STAM binding protein-like 1) | Using a linear mixed model, differential expression with age was identified in STAMBPL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STARD8 (StAR-related lipid transfer (START) domain containing 8) | Male and Female | 27 | 92 | Kidney | -14.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| Stat5a (signal transducer and activator of transcription 5A) | Male and Female | 3 | 23 | Hematological System | 7.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Stbd1 (starch binding domain 1) | Male and Female | 5 | 25 | Skeletal Muscle | 17.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| STC2 (stanniocalcin 2) | Using a linear mixed model, differential expression with age was identified in STC2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STEAP2 (STEAP family member 2, metalloreductase) | Using a linear mixed model, differential expression with age was identified in STEAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Stfa2l1 (stefin A2 like 1) | Male and Female | 2 | 26 | Lung | 53.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| STK31 (serine/threonine kinase 31) | Using a linear mixed model, differential expression with age was identified in STK31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STK32B (serine/threonine kinase 32B) | Using a linear mixed model, differential expression with age was identified in STK32B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STMN1 (stathmin 1) | Using a linear mixed model, differential expression with age was identified in STMN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Stmn1 (stathmin 1) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| STMN2 (stathmin-like 2) | Using a linear mixed model, differential expression with age was identified in STMN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STMN2 (stathmin-like 2) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Stmn2 (stathmin-like 2) | Male and Female | 3 | 23 | Hematological System | 97.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| STMN4 (stathmin-like 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of STMN4 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| STPG1 (sperm-tail PG-rich repeat containing 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of STPG1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| STRADB (STE20-related kinase adaptor beta) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Sts (steroid sulfatase) | Male and Female | 8 | 24 | Muscle | 27.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| STX11 (syntaxin 11) | Using a linear mixed model, differential expression with age was identified in STX11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STX16 (syntaxin 16) | Using a linear mixed model, differential expression with age was identified in STX16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Stx1a (syntaxin 1A (brain)) | Male and Female | 5 | 30 | Anatomical System | -3.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| STX4 (syntaxin 4) | Using a linear mixed model, differential expression with age was identified in STX4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| STXBP5 (syntaxin binding protein 5 (tomosyn)) | Using a linear mixed model, differential expression with age was identified in STXBP5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SUCLG1 (succinate-CoA ligase, alpha subunit) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SUGP2 (SURP and G patch domain containing 2) | Using a linear mixed model, differential expression with age was identified in SUGP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SULF2 (sulfatase 2) | Using a linear mixed model, differential expression with age was identified in SULF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SULT2B1 (sulfotransferase family, cytosolic, 2B, member 1) | Using a linear mixed model, differential expression with age was identified in SULT2B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SULT4A1 (sulfotransferase family 4A, member 1) | Using a linear mixed model, differential expression with age was identified in SULT4A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SUMF1 (sulfatase modifying factor 1) | Using a linear mixed model, differential expression with age was identified in SUMF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SUMO2 (SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1) | Using a linear mixed model, differential expression with age was identified in SVEP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Svs4 (seminal vesicle secretory protein 4) | Male and Female | 5 | 22 | Brain | 2642.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| SYN2 (synapsin II) | Male and Female | 26 | 106 | Brain | -29.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SYNC (syncoilin, intermediate filament protein) | Comparison of DNA methylation showed a significantly decreased methylation level of SYNC in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -16.0 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SYNC (syncoilin, intermediate filament protein) | Comparison of DNA methylation showed a significantly increased methylation level of SYNC in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 21.4 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| SYNGR1 (synaptogyrin 1) | Using a linear mixed model, differential expression with age was identified in SYNGR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SYNM (synemin, intermediate filament protein) | Using a linear mixed model, differential expression with age was identified in SYNM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Synm (synemin, intermediate filament protein) | Male and Female | 3 | 23 | Hematological System | 66.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| SYPL2 (synaptophysin-like 2) | Using a linear mixed model, differential expression with age was identified in SYPL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SYT1 (synaptotagmin I) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| SYT17 (synaptotagmin XVII) | Using a linear mixed model, differential expression with age was identified in SYT17 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SYT9 (synaptotagmin IX) | Using a linear mixed model, differential expression with age was identified in SYT9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SYTL2 (synaptotagmin-like 2) | Using a linear mixed model, differential expression with age was identified in SYTL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| SZRD1 (SUZ RNA binding domain containing 1) | Using a linear mixed model, differential expression with age was identified in SZRD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TACC2 (transforming, acidic coiled-coil containing protein 2) | Using a linear mixed model, differential expression with age was identified in TACC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAF10 (TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa) | Using a linear mixed model, differential expression with age was identified in TAF10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAF1C (TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa) | Using a linear mixed model, differential expression with age was identified in TAF1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa) | Using a linear mixed model, differential expression with age was identified in TAF5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAF7L (TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa) | Using a linear mixed model, differential expression with age was identified in TAF7L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAGLN3 (transgelin 3) | Using a linear mixed model, differential expression with age was identified in TAGLN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAGLN3 (transgelin 3) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)) | Using a linear mixed model, differential expression with age was identified in TAP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAP2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) | Using a linear mixed model, differential expression with age was identified in TAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TARBP1 (TAR (HIV-1) RNA binding protein 1) | Using a linear mixed model, differential expression with age was identified in TARBP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TARDBP (TAR DNA binding protein) | Using a linear mixed model, differential expression with age was identified in TARDBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TAZ (tafazzin) | Using a linear mixed model, differential expression with age was identified in TAZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TBATA (thymus, brain and testes associated) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of TBATA and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| TBC1D16 (TBC1 domain family, member 16) | Using a linear mixed model, differential expression with age was identified in TBC1D16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TBC1D2 (TBC1 domain family, member 2) | Using a linear mixed model, differential expression with age was identified in TBC1D2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TBC1D8 (TBC1 domain family, member 8 (with GRAM domain)) | Using a linear mixed model, differential expression with age was identified in TBC1D8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tbl1x (transducin (beta)-like 1 X-linked) | Male and Female | 8 | 24 | Muscle | 2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| TBX20 (T-box 20) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of TBX20 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| TBX4 (T-box 4) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of TBX4 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TBXAS1 (thromboxane A synthase 1 (platelet)) | Using a linear mixed model, differential expression with age was identified in TBXAS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TCERG1 (transcription elongation regulator 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TCF12 (transcription factor 12) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TCF25 (transcription factor 25 (basic helix-loop-helix)) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TCF4 (transcription factor 4) | At least seven CpG nucleotides in the first exon of TCF4 increase in methylation level with ageing. | Male and Female | 50 | 70 | Gastric Mucosa | 0.0 | 2804: Kim et al. (2008) "CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers." Carcinogenesis 29(8):1623-1631 (18635522) | |
| Tcfcp2l1 (transcription factor CP2-like 1) | Male and Female | 2 | 26 | Lung | -6.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Tcfcp2l1 (transcription factor CP2-like 1) | Male and Female | 2 | 15 | Hippocampus | 5.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| Tcfe3 (transcription factor E3) | Male and Female | 2 | 26 | Lung | -3.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TCHH (trichohyalin) | Using a linear mixed model, differential expression with age was identified in TCHH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TCHHL1 (trichohyalin-like 1) | Using a linear mixed model, differential expression with age was identified in TCHHL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TCHP (trichoplein, keratin filament binding) | Using a linear mixed model, differential expression with age was identified in TCHP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TCN2 (transcobalamin II) | Using a linear mixed model, differential expression with age was identified in TCN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tcra (T-cell receptor alpha chain) | Male and Female | 2 | 26 | Lung | 17.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TEX264 (testis expressed 264) | Using a linear mixed model, differential expression with age was identified in TEX264 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TF (transferrin) | Using a linear mixed model, differential expression with age was identified in TF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TFB1M (transcription factor B1, mitochondrial) | Using a linear mixed model, differential expression with age was identified in TFB1M in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tfdp1 (transcription factor Dp 1) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| TFF3 (trefoil factor 3 (intestinal)) | Using a linear mixed model, differential expression with age was identified in TFF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tff3 (trefoil factor 3, intestinal) | Male and Female | 6 | 22 | Liver | 97.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| TFG (TRK-fused gene) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of TFG and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TGFBI (transforming growth factor, beta-induced, 68kDa) | Using a linear mixed model, differential expression with age was identified in TGFBI in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TGM2 (transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)) | Male and Female | 26 | 106 | Brain | 18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| THBS2 (thrombospondin 2) | Using a linear mixed model, differential expression with age was identified in THBS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Thbs3 (thrombospondin 3) | Male and Female | 2 | 26 | Lung | -12.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| THOC1 (THO complex 1) | Using a linear mixed model, differential expression with age was identified in THOC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| THRSP (thyroid hormone responsive) | Using a linear mixed model, differential expression with age was identified in THRSP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| THY1 (Thy-1 cell surface antigen) | Using a linear mixed model, differential expression with age was identified in THY1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| THY1 (Thy-1 cell surface antigen) | Using a linear mixed model, differential expression with age was identified in THY1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| THY1 (Thy-1 cell surface antigen) | Male and Female | 26 | 106 | Brain | -7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Thy1 (thymus cell antigen 1, theta) | Male and Female | 2 | 26 | Lung | 15.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TIAL1 (TIA1 cytotoxic granule-associated RNA binding protein-like 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of TIAL1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TIMM17A (translocase of inner mitochondrial membrane 17 homolog A (yeast)) | Male and Female | 26 | 106 | Brain | -13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TIMP1 (TIMP metallopeptidase inhibitor 1) | Using a linear mixed model, differential expression with age was identified in TIMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TJAP1 (tight junction associated protein 1 (peripheral)) | Using a linear mixed model, differential expression with age was identified in TJAP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TLCD1 (TLC domain containing 1) | Using a linear mixed model, differential expression with age was identified in TLCD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TLE2 (transducin-like enhancer of split 2) | Using a linear mixed model, differential expression with age was identified in TLE2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TLN2 (talin 2) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TLR1 (toll-like receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 39.77 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR1 (toll-like receptor 1) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 87.35 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR2 (toll-like receptor 2) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe TLR2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 185.14 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR2 (toll-like receptor 2) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 189.07 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR2 (toll-like receptor 2) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TLR2 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 155.56 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR3 (toll-like receptor 3) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 52.96 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 150.87 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 115.49 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 148.44 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 46.0 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 114.73 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 83.71 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 65.24 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 69.38 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR4 (toll-like receptor 4) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR4 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 82.15 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR5 (toll-like receptor 5) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 96.4 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR5 (toll-like receptor 5) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 69.17 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR5 (toll-like receptor 5) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TLR5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 48.66 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR7 (toll-like receptor 7) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TLR7 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 38.78 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR7 (toll-like receptor 7) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR7 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 94.74 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR7 (toll-like receptor 7) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR7 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 56.5 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TLR8 (toll-like receptor 8) | Gene expression showed a significant (p<0.01) increase in the expression of hippocampus TLR8 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Hippocampus | 39.68 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| Tm2d2 (TM2 domain containing 2) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TM7SF2 (transmembrane 7 superfamily member 2) | Using a linear mixed model, differential expression with age was identified in TM7SF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMBIM6 (transmembrane BAX inhibitor motif containing 6) | Using a linear mixed model, differential expression with age was identified in TMBIM6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMED3 (transmembrane emp24 protein transport domain containing 3) | Using a linear mixed model, differential expression with age was identified in TMED3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tmed7 (transmembrane emp24 protein transport domain containing 7) | Male and Female | 8 | 24 | Muscle | 5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Tmem100 (transmembrane protein 100) | Male and Female | 8 | 24 | Muscle | 13.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| TMEM119 (transmembrane protein 119) | Using a linear mixed model, differential expression with age was identified in TMEM119 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM125 (transmembrane protein 125) | Using a linear mixed model, differential expression with age was identified in TMEM125 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM135 (transmembrane protein 135) | Gene expression showed a significant (p<E-3) decrease in the expression of TMEM135 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -67.53 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TMEM141 (transmembrane protein 141) | Using a linear mixed model, differential expression with age was identified in TMEM141 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tmem158 (transmembrane protein 158) | Male and Female | 3 | 23 | Hematological System | 16.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| TMEM163 (transmembrane protein 163) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of TMEM163 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| TMEM164 (transmembrane protein 164) | Using a linear mixed model, differential expression with age was identified in TMEM164 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM167B (transmembrane protein 167B) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TMEM178A (transmembrane protein 178A) | Using a linear mixed model, differential expression with age was identified in TMEM178A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM178A (transmembrane protein 178A) | Using a linear mixed model, differential expression with age was identified in TMEM178A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM189 (transmembrane protein 189) | Using a linear mixed model, differential expression with age was identified in TMEM189 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM19 (transmembrane protein 19) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TMEM194A (transmembrane protein 194A) | Using a linear mixed model, differential expression with age was identified in TMEM194A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM208 (transmembrane protein 208) | Using a linear mixed model, differential expression with age was identified in TMEM208 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM219 (transmembrane protein 219) | Using a linear mixed model, differential expression with age was identified in TMEM219 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM249 (transmembrane protein 249) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of TMEM249 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TMEM254 (transmembrane protein 254) | Using a linear mixed model, differential expression with age was identified in TMEM254 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM258 (transmembrane protein 258) | Using a linear mixed model, differential expression with age was identified in TMEM258 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM31 (transmembrane protein 31) | Using a linear mixed model, differential expression with age was identified in TMEM31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM33 (transmembrane protein 33) | Gene expression showed a significant (p<E-3) decrease in the expression of TMEM33 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -63.9 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TMEM50B (transmembrane protein 50B) | Using a linear mixed model, differential expression with age was identified in TMEM50B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM56 (transmembrane protein 56) | Using a linear mixed model, differential expression with age was identified in TMEM56 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM59L (transmembrane protein 59-like) | Male and Female | 20 | 75 | Skeletal Muscle | -8.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TMEM71 (transmembrane protein 71) | Using a linear mixed model, differential expression with age was identified in TMEM71 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM74B (transmembrane protein 74B) | Using a linear mixed model, differential expression with age was identified in TMEM74B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM91 (transmembrane protein 91) | Using a linear mixed model, differential expression with age was identified in TMEM91 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM97 (transmembrane protein 97) | Using a linear mixed model, differential expression with age was identified in TMEM97 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM98 (transmembrane protein 98) | Using a linear mixed model, differential expression with age was identified in TMEM98 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMEM99 (transmembrane protein 99) | Using a linear mixed model, differential expression with age was identified in TMEM99 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMOD1 (tropomodulin 1) | Using a linear mixed model, differential expression with age was identified in TMOD1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TMOD3 (tropomodulin 3 (ubiquitous)) | Gene expression showed a significant (p<E-3) decrease in the expression of TMOD3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -35.9 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TMUB2 (transmembrane and ubiquitin-like domain containing 2) | Using a linear mixed model, differential expression with age was identified in TMUB2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tmx1 (thioredoxin-related transmembrane protein 1) | Male and Female | 8 | 24 | Muscle | 4.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| TMX3 (thioredoxin-related transmembrane protein 3) | Using a linear mixed model, differential expression with age was identified in TMX3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNF (tumor necrosis factor) | An age-related demethylation of CpG motifs in the TNF promoter was observed in human peripheral blood leucocytes and macrophages. | Male and Female | -1 | -1 | Macrophage, Leukocyte | 2959: Gowers et al. (2011) "Age-related loss of CpG methylation in the tumour necrosis factor promoter." Cytokine 56(3):792-797 (22004920) | ||
| TNFAIP2 (tumor necrosis factor, alpha-induced protein 2) | Using a linear mixed model, differential expression with age was identified in TNFAIP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tnfaip2 (tumor necrosis factor, alpha-induced protein 2) | Male and Female | 3 | 23 | Hematological System | 14.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Tnfrsf13c (tumor necrosis factor receptor superfamily, member 13c) | Male and Female | 3 | 23 | Hematological System | -22.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| TNFRSF17 (tumor necrosis factor receptor superfamily, member 17) | Comparison of DNA methylation showed a significantly decreased methylation level of TNFRSF17 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.6 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| TNFRSF17 (tumor necrosis factor receptor superfamily, member 17) | Comparison of DNA methylation showed a significantly increased methylation level of TNFRSF17 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 18.8 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| TNFRSF19 (tumor necrosis factor receptor superfamily, member 19) | Using a linear mixed model, differential expression with age was identified in TNFRSF19 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNFRSF21 (tumor necrosis factor receptor superfamily, member 21) | Using a linear mixed model, differential expression with age was identified in TNFRSF21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNFRSF21 (tumor necrosis factor receptor superfamily, member 21) | Male and Female | 26 | 106 | Brain | -18.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TNFRSF25 (tumor necrosis factor receptor superfamily, member 25) | Using a linear mixed model, differential expression with age was identified in TNFRSF25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNFSF13B (tumor necrosis factor (ligand) superfamily, member 13b) | Using a linear mixed model, differential expression with age was identified in TNFSF13B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNK2 (tyrosine kinase, non-receptor, 2) | Using a linear mixed model, differential expression with age was identified in TNK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNN (tenascin N) | Using a linear mixed model, differential expression with age was identified in TNN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNNI2 (troponin I type 2 (skeletal, fast)) | Using a linear mixed model, differential expression with age was identified in TNNI2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNNT2 (troponin T type 2 (cardiac)) | Using a linear mixed model, differential expression with age was identified in TNNT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TNPO2 (transportin 2) | Using a linear mixed model, differential expression with age was identified in TNPO2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -36.33 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -53.57 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -59.51 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -61.54 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | -57.78 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TOLLIP (toll interacting protein) | Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe TOLLIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | -33.42 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1) | Using a linear mixed model, differential expression with age was identified in TP53AIP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TPBG (trophoblast glycoprotein) | Male and Female | 26 | 106 | Brain | -13.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TPD52 (tumor protein D52) | Using a linear mixed model, differential expression with age was identified in TPD52 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tpd52l1 (tumor protein D52-like 1) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| TPM2 (tropomyosin 2 (beta)) | Using a linear mixed model, differential expression with age was identified in TPM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TPP1 (tripeptidyl peptidase I) | Using a linear mixed model, differential expression with age was identified in TPP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TPPP (tubulin polymerization promoting protein) | Male and Female | 26 | 106 | Brain | -21.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TPPP3 (tubulin polymerization-promoting protein family member 3) | Using a linear mixed model, differential expression with age was identified in TPPP3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TPPP3 (tubulin polymerization-promoting protein family member 3) | Male and Female | 20 | 75 | Skeletal Muscle | 48.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TPR (translocated promoter region, nuclear basket protein) | Using a linear mixed model, differential expression with age was identified in TPR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TPRG1 (tumor protein p63 regulated 1) | Using a linear mixed model, differential expression with age was identified in TPRG1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRAF6 (TNF receptor-associated factor 6, E3 ubiquitin protein ligase) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of TRAF6 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TRAK1 (trafficking protein, kinesin binding 1) | Using a linear mixed model, differential expression with age was identified in TRAK1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRAK1 (trafficking protein, kinesin binding 1) | Using a linear mixed model, differential expression with age was identified in TRAK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRAPPC1 (trafficking protein particle complex 1) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TRAPPC5 (trafficking protein particle complex 5) | Using a linear mixed model, differential expression with age was identified in TRAPPC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Trf (transferrin) | Male and Female | 8 | 24 | Muscle | 11.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| TRHDE (thyrotropin-releasing hormone degrading enzyme) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of TRHDE and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| TRIM15 (tripartite motif-containing 15) | Using a linear mixed model, differential expression with age was identified in TRIM15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRIM15 (tripartite motif-containing 15) | Male and Female | 22 | 73 | Skeletal Muscle | 18.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| TRIM27 (tripartite motif-containing 27) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TRIM39 (tripartite motif containing 39) | Using a linear mixed model, differential expression with age was identified in TRIM39 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Trim43a (tripartite motif-containing 43A) | Male and Female | 6 | 22 | Liver | -5.0 | <0.001 | 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019) | |
| Trim46 (tripartite motif-containing 46) | Male and Female | 3 | 23 | Hematological System | 19.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| TRIM52 (tripartite motif containing 52) | Using a linear mixed model, differential expression with age was identified in TRIM52 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRIM55 (tripartite motif containing 55) | Using a linear mixed model, differential expression with age was identified in TRIM55 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRIM8 (tripartite motif containing 8) | Using a linear mixed model, differential expression with age was identified in TRIM8 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRIOBP (TRIO and F-actin binding protein) | Using a linear mixed model, differential expression with age was identified in TRIOBP in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRIOBP (TRIO and F-actin binding protein) | Gene expression showed a significant (p<E-3) increase in the expression of TRIOBP in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 73.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TRIP12 (thyroid hormone receptor interactor 12) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TRIT1 (tRNA isopentenyltransferase 1) | Using a linear mixed model, differential expression with age was identified in TRIT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRMT112 (tRNA methyltransferase 11-2 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Trmt5 (TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)) | Male and Female | 2 | 26 | Lung | 8.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TRMT5 (TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Trmt61a (tRNA methyltransferase 61 homolog A (S. cerevisiae)) | Male and Female | 5 | 22 | Brain | 6.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| TRPC1 (transient receptor potential cation channel, subfamily C, member 1) | Using a linear mixed model, differential expression with age was identified in TRPC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRPM4 (transient receptor potential cation channel, subfamily M, member 4) | Using a linear mixed model, differential expression with age was identified in TRPM4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRPS1 (trichorhinophalangeal syndrome I) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of TRPS1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Trpt1 (tRNA phosphotransferase 1) | Male and Female | 2 | 26 | Lung | 12.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TRPV1 (transient receptor potential cation channel, subfamily V, member 1) | Using a linear mixed model, differential expression with age was identified in TRPV1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TRPV2 (transient receptor potential cation channel, subfamily V, member 2) | Using a linear mixed model, differential expression with age was identified in TRPV2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSC1 (tuberous sclerosis 1) | Using a linear mixed model, differential expression with age was identified in TSC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSHZ1 (teashirt zinc finger homeobox 1) | Gene expression showed a significant (p<E-3) increase in the expression of TSHZ1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 57.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TSHZ2 (teashirt zinc finger homeobox 2) | Using a linear mixed model, differential expression with age was identified in TSHZ2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSKU (tsukushi, small leucine rich proteoglycan) | Using a linear mixed model, differential expression with age was identified in TSKU in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSKU (tsukushi, small leucine rich proteoglycan) | Using a linear mixed model, differential expression with age was identified in TSKU in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSNAX (translin-associated factor X) | Male and Female | 20 | 75 | Skeletal Muscle | 4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TSPAN31 (tetraspanin 31) | Using a linear mixed model, differential expression with age was identified in TSPAN31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSPAN6 (tetraspanin 6) | Using a linear mixed model, differential expression with age was identified in TSPAN6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSPAN8 (tetraspanin 8) | Comparison of DNA methylation showed a significantly decreased methylation level of TSPAN8 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.9 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| TSPAN8 (tetraspanin 8) | Comparison of DNA methylation showed a significantly increased methylation level of TSPAN8 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 36.4 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| TSPAN9 (tetraspanin 9) | Using a linear mixed model, differential expression with age was identified in TSPAN9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSPYL2 (TSPY-like 2) | Using a linear mixed model, differential expression with age was identified in TSPYL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TSPYL2 (TSPY-like 2) | Male and Female | 26 | 106 | Brain | -14.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| TSPYL5 (TSPY-like 5) | Gene expression showed a significant (p<E-3) decrease in the expression of TSPYL5 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -45.36 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| TST (thiosulfate sulfurtransferase (rhodanese)) | Using a linear mixed model, differential expression with age was identified in TST in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TST (thiosulfate sulfurtransferase (rhodanese)) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TTC13 (tetratricopeptide repeat domain 13) | Using a linear mixed model, differential expression with age was identified in TTC13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ttc18 (tetratricopeptide repeat domain 18) | Male and Female | 2 | 26 | Lung | 9.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| TTC31 (tetratricopeptide repeat domain 31) | Using a linear mixed model, differential expression with age was identified in TTC31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TTC32 (tetratricopeptide repeat domain 32) | Using a linear mixed model, differential expression with age was identified in TTC32 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TTC39B (tetratricopeptide repeat domain 39B) | Using a linear mixed model, differential expression with age was identified in TTC39B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TTLL3 (tubulin tyrosine ligase-like family, member 3) | Using a linear mixed model, differential expression with age was identified in TTLL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TTYH3 (tweety family member 3) | Using a linear mixed model, differential expression with age was identified in TTYH3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Tubg1 (tubulin, gamma 1) | Male and Female | 2 | 15 | Hippocampus | -4.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| TUBGCP6 (tubulin, gamma complex associated protein 6) | Using a linear mixed model, differential expression with age was identified in TUBGCP6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TUFM (Tu translation elongation factor, mitochondrial) | Using a linear mixed model, differential expression with age was identified in TUFM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TUFT1 (tuftelin 1) | Using a linear mixed model, differential expression with age was identified in TUFT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TWF2 (twinfilin actin-binding protein 2) | Using a linear mixed model, differential expression with age was identified in TWF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TWIST1 (twist family bHLH transcription factor 1) | Using a linear mixed model, differential expression with age was identified in TWIST1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TXNDC5 (thioredoxin domain containing 5 (endoplasmic reticulum)) | Using a linear mixed model, differential expression with age was identified in TXNDC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TXNIP (thioredoxin interacting protein) | Using a linear mixed model, differential expression with age was identified in TXNIP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 143.11 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 250.19 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Frontal Lobe | 277.8 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 146.62 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Parietal Lobe | 124.83 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNIP (thioredoxin interacting protein) | Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe TXNIP from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) | Male and Female | 20 | 99 | Temporal Lobe | 130.7 | None | 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372) |
| TXNL4A (thioredoxin-like 4A) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| TYROBP (TYRO protein tyrosine kinase binding protein) | Using a linear mixed model, differential expression with age was identified in TYROBP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| TYRP1 (tyrosinase-related protein 1) | Male and Female | 27 | 92 | Kidney | -21.0 | <0.001 | 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319) | |
| TYSND1 (trypsin domain containing 1) | Using a linear mixed model, differential expression with age was identified in TYSND1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| U2AF1 (U2 small nuclear RNA auxiliary factor 1) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| UBE2D2 (ubiquitin-conjugating enzyme E2D 2) | Gene expression showed a significant (p<E-3) decrease in the expression of UBE2D2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -48.19 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| UBE2D4 (ubiquitin-conjugating enzyme E2D 4 (putative)) | Using a linear mixed model, differential expression with age was identified in UBE2D4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UBE2E2 (ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)) | Using a linear mixed model, differential expression with age was identified in UBE2E2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UBE2E2 (ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| UBE2E3 (ubiquitin-conjugating enzyme E2E 3) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of UBE2E3 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Ube2g1 (ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)) | Male and Female | 5 | 25 | Skeletal Muscle | -2.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Ube2l3 (ubiquitin-conjugating enzyme E2L 3) | Male and Female | 8 | 24 | Muscle | -2.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| UBE4B (ubiquitination factor E4B) | Gene expression showed a significant (p<E-3) decrease in the expression of UBE4B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -43.82 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| UBIAD1 (UbiA prenyltransferase domain containing 1) | Using a linear mixed model, differential expression with age was identified in UBIAD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UBL7 (ubiquitin-like 7) | Using a linear mixed model, differential expression with age was identified in UBL7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Ubqln4 (ubiquilin 4) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| UBR5 (ubiquitin protein ligase E3 component n-recognin 5) | Using a linear mixed model, differential expression with age was identified in UBR5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UBTF (upstream binding transcription factor, RNA polymerase I) | Using a linear mixed model, differential expression with age was identified in UBTF in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UCKL1 (uridine-cytidine kinase 1-like 1) | Using a linear mixed model, differential expression with age was identified in UCKL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UCKL1 (uridine-cytidine kinase 1-like 1) | Gene expression showed a significant (p<E-3) increase in the expression of UCKL1 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 86.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| UCN2 (urocortin 2) | Using a linear mixed model, differential expression with age was identified in UCN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UCP2 (uncoupling protein 2 (mitochondrial, proton carrier)) | Using a linear mixed model, differential expression with age was identified in UCP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UCRC (ubiquinol-cytochrome c reductase complex (7.2 kD)) | Using a linear mixed model, differential expression with age was identified in UQCR10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UCRC (ubiquinol-cytochrome c reductase complex (7.2 kD)) | Male and Female | 20 | 75 | Skeletal Muscle | -2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| UEVLD (UEV and lactate/malate dehyrogenase domains) | Using a linear mixed model, differential expression with age was identified in UEVLD in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UGT2B17 (UDP glucuronosyltransferase 2 family, polypeptide B17) | Using a linear mixed model, differential expression with age was identified in UGT2B17 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UIMC1 (ubiquitin interaction motif containing 1) | Using a linear mixed model, differential expression with age was identified in UIMC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ULK3 (unc-51 like kinase 3) | Using a linear mixed model, differential expression with age was identified in ULK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UNC5B (unc-5 homolog B (C. elegans)) | Using a linear mixed model, differential expression with age was identified in UNC5B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UPB1 (ureidopropionase, beta) | Using a linear mixed model, differential expression with age was identified in UPB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UPF2 (UPF2 regulator of nonsense transcripts homolog (yeast)) | Using a linear mixed model, differential expression with age was identified in UPF2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UPF3A (UPF3 regulator of nonsense transcripts homolog A (yeast)) | Using a linear mixed model, differential expression with age was identified in UPF3A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UPF3B (UPF3 regulator of nonsense transcripts homolog B (yeast)) | Using a linear mixed model, differential expression with age was identified in UPF3B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UQCRC2 (ubiquinol-cytochrome c reductase core protein II) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) | Male and Female | 22 | 73 | Skeletal Muscle | -4.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| UQCRH (ubiquinol-cytochrome c reductase hinge protein) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| UQCRH (ubiquinol-cytochrome c reductase hinge protein) | Male and Female | 22 | 73 | Skeletal Muscle | -4.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| UQCRQ (ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa) | Using a linear mixed model, differential expression with age was identified in UQCRQ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| USP24 (ubiquitin specific peptidase 24) | Using a linear mixed model, differential expression with age was identified in USP24 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Usp37 (ubiquitin specific peptidase 37) | Male and Female | 5 | 22 | Brain | 7.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| USP42 (ubiquitin specific peptidase 42) | Gene expression showed a significant (p<E-3) increase in the expression of USP42 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 60.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| USP6 (ubiquitin specific peptidase 6 (Tre-2 oncogene)) | Male and Female | 20 | 75 | Skeletal Muscle | 5.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| USPL1 (ubiquitin specific peptidase like 1) | Using a linear mixed model, differential expression with age was identified in USPL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| UVSSA (UV-stimulated scaffold protein A) | Using a linear mixed model, differential expression with age was identified in UVSSA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VAMP2 (vesicle-associated membrane protein 2 (synaptobrevin 2)) | Male and Female | 26 | 106 | Brain | -4.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VAMP3 (vesicle-associated membrane protein 3 (cellubrevin)) | Male and Female | 26 | 106 | Brain | 7.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VAMP4 (vesicle-associated membrane protein 4) | Using a linear mixed model, differential expression with age was identified in VAMP4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VANGL2 (VANGL planar cell polarity protein 2) | Using a linear mixed model, differential expression with age was identified in VANGL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VASN (vasorin) | Using a linear mixed model, differential expression with age was identified in VASN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Vasn (vasorin) | Male and Female | 3 | 23 | Hematological System | -10.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| VAT1 (vesicle amine transport 1) | Using a linear mixed model, differential expression with age was identified in VAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VAV3 (vav 3 guanine nucleotide exchange factor) | Using a linear mixed model, differential expression with age was identified in VAV3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VCAM1 (vascular cell adhesion molecule 1) | Using a linear mixed model, differential expression with age was identified in VCAM1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VCAN (versican) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VDAC1 (voltage-dependent anion channel 1) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VEGFB (vascular endothelial growth factor B) | Male and Female | 20 | 75 | Skeletal Muscle | -6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| VEGFC (vascular endothelial growth factor C) | Using a linear mixed model, differential expression with age was identified in VEGFC in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VEZT (vezatin, adherens junctions transmembrane protein) | Using a linear mixed model, differential expression with age was identified in VEZT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VIM (vimentin) | Male and Female | 26 | 106 | Brain | 11.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VIMP (VCP-interacting membrane protein) | Using a linear mixed model, differential expression with age was identified in VIMP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VIPR1 (vasoactive intestinal peptide receptor 1) | Using a linear mixed model, differential expression with age was identified in VIPR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VKORC1L1 (vitamin K epoxide reductase complex, subunit 1-like 1) | Using a linear mixed model, differential expression with age was identified in VKORC1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VLDLR (very low density lipoprotein receptor) | Male and Female | 20 | 75 | Skeletal Muscle | -4.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| VMP1 (vacuole membrane protein 1) | Using a linear mixed model, differential expression with age was identified in VMP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VPS13A (vacuolar protein sorting 13 homolog A (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in VPS13A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VPS13C (vacuolar protein sorting 13 homolog C (S. cerevisiae)) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| VPS13C (vacuolar protein sorting 13 homolog C (S. cerevisiae)) | Gene expression showed a significant (p<E-3) decrease in the expression of VPS13C in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -58.68 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| VPS33B (vacuolar protein sorting 33 homolog B (yeast)) | Using a linear mixed model, differential expression with age was identified in VPS33B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VPS45 (vacuolar protein sorting 45 homolog (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in VPS45 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VSIG4 (V-set and immunoglobulin domain containing 4) | Using a linear mixed model, differential expression with age was identified in VSIG4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| VSNL1 (visinin-like 1) | Male and Female | 26 | 106 | Brain | -6.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| VTI1B (vesicle transport through interaction with t-SNAREs homolog 1B (yeast)) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Vtn (vitronectin) | Male and Female | 5 | 30 | Anatomical System | 4.0 | <0.001 | 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876) | |
| VWA5A (von Willebrand factor A domain containing 5A) | Gene expression showed a significant (p<E-3) decrease in the expression of VWA5A in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -55.95 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| VWF (von Willebrand factor) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of VWF and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| Wdfy4 (WD repeat and FYVE domain containing 4) | Male and Female | 3 | 23 | Hematological System | -10.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| WDR12 (WD repeat domain 12) | Male and Female | 20 | 75 | Skeletal Muscle | -3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Wdr31 (WD repeat domain 31) | Male and Female | 2 | 26 | Lung | 11.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| WDR33 (WD repeat domain 33) | Using a linear mixed model, differential expression with age was identified in WDR33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WDR37 (WD repeat domain 37) | Using a linear mixed model, differential expression with age was identified in WDR37 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Wdr4 (WD repeat domain 4) | Male and Female | 8 | 24 | Muscle | -5.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| WDR5 (WD repeat domain 5) | Using a linear mixed model, differential expression with age was identified in WDR5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WDR59 (WD repeat domain 59) | Using a linear mixed model, differential expression with age was identified in WDR59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WDR60 (WD repeat domain 60) | Using a linear mixed model, differential expression with age was identified in WDR60 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WDR75 (WD repeat domain 75) | Using a linear mixed model, differential expression with age was identified in WDR75 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WDR91 (WD repeat domain 91) | Using a linear mixed model, differential expression with age was identified in WDR91 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Wisp1 (WNT1 inducible signaling pathway protein 1) | Male and Female | 2 | 26 | Lung | -20.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| WISP2 (WNT1 inducible signaling pathway protein 2) | Using a linear mixed model, differential expression with age was identified in WISP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WISP2 (WNT1 inducible signaling pathway protein 2) | Comparison of DNA methylation showed a significantly decreased methylation level of WISP2 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -17.7 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| WISP2 (WNT1 inducible signaling pathway protein 2) | Comparison of DNA methylation showed a significantly decreased methylation level of WISP2 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | -23.5 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| Wnt10a (wingless related MMTV integration site 10a) | Male and Female | 4 | 15 | Cochlea | 16.0 | <0.001 | 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326) | |
| WNT10A (wingless-type MMTV integration site family, member 10A) | Using a linear mixed model, differential expression with age was identified in WNT10A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WNT3 (wingless-type MMTV integration site family, member 3) | Using a linear mixed model, differential expression with age was identified in WNT3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WNT3A (wingless-type MMTV integration site family, member 3A) | Using a linear mixed model, differential expression with age was identified in WNT3A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Wnt4 (wingless-related MMTV integration site 4) | Male and Female | 3 | 23 | Hematological System | 44.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| WNT4 (wingless-type MMTV integration site family, member 4) | Using a linear mixed model, differential expression with age was identified in WNT4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Wnt5a (wingless-related MMTV integration site 5A) | Male and Female | 3 | 23 | Hematological System | 34.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| WRN (Werner syndrome, RecQ helicase-like) | In a study comparing young (22-37 years old), middle-aged (60-69 years old) and long-lived (90-100) individuals, it was shown that the expression of WRN mRNA steadily decreases with age. The level of WRN mRNA in the old was approximately half of the level found in the young. Notably, the mean levels of the WRN mRNA were similar in men and women. | Male and Female | 22 | 100 | Blood, Immune System | -52.0 | None | 2799: Polosak et al. (2011) "Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells." J. Gerontol. A Biol. Sci. Med. Sci. 66(1):19-25 (20855428) |
| WSB2 (WD repeat and SOCS box-containing 2) | Male and Female | 26 | 106 | Brain | -5.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| WWC2 (WW and C2 domain containing 2) | Using a linear mixed model, differential expression with age was identified in WWC2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| WWTR1 (WW domain containing transcription regulator 1) | Male and Female | 26 | 106 | Brain | 24.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| XAF1 (XIAP associated factor 1) | Using a linear mixed model, differential expression with age was identified in XAF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Xiap (X-linked inhibitor of apoptosis) | Male and Female | 5 | 25 | Skeletal Muscle | -13.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| XIST (X inactive specific transcript (non-protein coding)) | Using a linear mixed model, differential expression with age was identified in XIST in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| XPC (xeroderma pigmentosum, complementation group C) | Using a linear mixed model, differential expression with age was identified in XPC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| XPC (xeroderma pigmentosum, complementation group C) | Male and Female | 22 | 73 | Skeletal Muscle | 6.0 | <0.001 | 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100) | |
| XPC (xeroderma pigmentosum, complementation group C) | Male and Female | 20 | 75 | Skeletal Muscle | 7.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound) | Using a linear mixed model, differential expression with age was identified in XPNPEP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| XPO5 (exportin 5) | Using a linear mixed model, differential expression with age was identified in XPO5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| XPO6 (exportin 6) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| XYLT2 (xylosyltransferase II) | Using a linear mixed model, differential expression with age was identified in XYLT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| YEATS2 (YEATS domain containing 2) | Using a linear mixed model, differential expression with age was identified in YEATS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| YIF1B (Yip1 interacting factor homolog B (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in YIF1B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| YIF1B (Yip1 interacting factor homolog B (S. cerevisiae)) | Using a linear mixed model, differential expression with age was identified in YIF1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| YTHDC1 (YTH domain containing 1) | Using a linear mixed model, differential expression with age was identified in YTHDC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ZBED1 (zinc finger, BED-type containing 1) | Using a linear mixed model, differential expression with age was identified in ZBED1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZBED5 (zinc finger, BED-type containing 5) | Using a linear mixed model, differential expression with age was identified in ZBED5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZBTB1 (zinc finger and BTB domain containing 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of ZBTB1 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| ZBTB10 (zinc finger and BTB domain containing 10) | Gene expression showed a significant (p<E-3) decrease in the expression of ZBTB10 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -59.35 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZBTB16 (zinc finger and BTB domain containing 16) | Using a linear mixed model, differential expression with age was identified in ZBTB16 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Zbtb16 (zinc finger and BTB domain containing 16) | Male and Female | 2 | 15 | Hippocampus | 2.0 | <0.001 | 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854) | |
| ZBTB18 (zinc finger and BTB domain containing 18) | Gene expression showed a significant (p<E-3) decrease in the expression of ZNF238 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -39.02 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZBTB25 (zinc finger and BTB domain containing 25) | Using a linear mixed model, differential expression with age was identified in ZBTB25 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZBTB4 (zinc finger and BTB domain containing 4) | Male and Female | 20 | 75 | Skeletal Muscle | 2.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Zc3hav1 (zinc finger CCCH type, antiviral 1) | Male and Female | 3 | 23 | Hematological System | -5.0 | <0.001 | 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997) | |
| Zcchc18 (zinc finger, CCHC domain containing 18) | Male and Female | 2 | 26 | Lung | 14.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ZCCHC24 (zinc finger, CCHC domain containing 24) | Male and Female | 26 | 106 | Brain | 15.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ZDHHC16 (zinc finger, DHHC-type containing 16) | Using a linear mixed model, differential expression with age was identified in ZDHHC16 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZDHHC24 (zinc finger, DHHC-type containing 24) | Using a linear mixed model, differential expression with age was identified in ZDHHC24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZDHHC6 (zinc finger, DHHC-type containing 6) | Using a linear mixed model, differential expression with age was identified in ZDHHC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZDHHC8 (zinc finger, DHHC-type containing 8) | Using a linear mixed model, differential expression with age was identified in ZDHHC8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZEB2 (zinc finger E-box binding homeobox 2) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of ZEB2 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| ZER1 (zer-1 homolog (C. elegans)) | Male and Female | 26 | 106 | Brain | -16.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Zfhx3 (zinc finger homeobox 3) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| Zfp251 (zinc finger protein 251) | Male and Female | 2 | 26 | Lung | -4.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ZFP3 (ZFP3 zinc finger protein) | Gene expression showed a significant (p<E-3) increase in the expression of ZFP3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 51.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZFP36L1 (zinc finger protein 36, C3H type-like 1) | Male and Female | 20 | 75 | Skeletal Muscle | 6.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| Zfp62 (zinc finger protein 62) | Male and Female | 8 | 24 | Muscle | 6.0 | <0.001 | 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352) | |
| Zfp64 (zinc finger protein 64) | Male and Female | 5 | 22 | Brain | 5.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Zfp651 (zinc finger protein 651) | Male and Female | 5 | 25 | Skeletal Muscle | 7.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Zfp68 (zinc finger protein 68) | Male and Female | 5 | 22 | Brain | 5.0 | <0.001 | 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311) | |
| Zfp84 (zinc finger protein 84) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ZFR (zinc finger RNA binding protein) | Gene expression showed a significant (p<E-3) increase in the expression of ZFR in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | 150.0 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZFYVE20 (zinc finger, FYVE domain containing 20) | Using a linear mixed model, differential expression with age was identified in ZFYVE20 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZFYVE20 (zinc finger, FYVE domain containing 20) | Male and Female | 20 | 75 | Skeletal Muscle | 3.0 | <0.001 | 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983) | |
| ZFYVE26 (zinc finger, FYVE domain containing 26) | Using a linear mixed model, differential expression with age was identified in ZFYVE26 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZGPAT (zinc finger, CCCH-type with G patch domain) | Using a linear mixed model, differential expression with age was identified in ZGPAT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZHX2 (zinc fingers and homeoboxes 2) | Male and Female | 26 | 106 | Brain | 20.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ZIC1 (Zic family member 1) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ZIC1 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ZMIZ2 (zinc finger, MIZ-type containing 2) | Using a linear mixed model, differential expression with age was identified in ZMIZ2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZMIZ2 (zinc finger, MIZ-type containing 2) | Male and Female | 26 | 106 | Brain | -17.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| Zmym1 (zinc finger, MYM domain containing 1) | Male and Female | 2 | 26 | Lung | -10.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ZMYM2 (zinc finger, MYM-type 2) | Using a linear mixed model, differential expression with age was identified in ZMYM2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZMYND8 (zinc finger, MYND-type containing 8) | Using a linear mixed model, differential expression with age was identified in ZMYND8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZMYND8 (zinc finger, MYND-type containing 8) | Comparison of DNA methylation showed a significantly increased methylation level of ZMYND8 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 19.9 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ZMYND8 (zinc finger, MYND-type containing 8) | Comparison of DNA methylation showed a significantly increased methylation level of ZMYND8 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 19.5 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ZNF175 (zinc finger protein 175) | Using a linear mixed model, differential expression with age was identified in ZNF175 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF177 (zinc finger protein 177) | Using a linear mixed model, differential expression with age was identified in ZNF177 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF195 (zinc finger protein 195) | Using a linear mixed model, differential expression with age was identified in ZNF195 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF224 (zinc finger protein 224) | Using a linear mixed model, differential expression with age was identified in ZNF224 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF248 (zinc finger protein 248) | Using a linear mixed model, differential expression with age was identified in ZNF248 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF25 (zinc finger protein 25) | Gene expression showed a significant (p<E-3) decrease in the expression of ZNF25 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -51.46 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZNF266 (zinc finger protein 266) | Using a linear mixed model, differential expression with age was identified in ZNF266 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF273 (zinc finger protein 273) | Using a linear mixed model, differential expression with age was identified in ZNF273 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF280A (zinc finger protein 280A) | Male and Female | 26 | 106 | Brain | -10.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ZNF295-AS1 (ZNF295 antisense RNA 1) | Using a linear mixed model, differential expression with age was identified in ZNF295-AS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF311 (zinc finger protein 311) | Using a linear mixed model, differential expression with age was identified in ZNF311 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF32 (zinc finger protein 32) | Using a linear mixed model, differential expression with age was identified in ZNF32 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF331 (zinc finger protein 331) | Using a linear mixed model, differential expression with age was identified in ZNF331 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF333 (zinc finger protein 333) | Using a linear mixed model, differential expression with age was identified in ZNF333 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF33B (zinc finger protein 33B) | Using a linear mixed model, differential expression with age was identified in ZNF33B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF385B (zinc finger protein 385B) | Using a linear mixed model, differential expression with age was identified in ZNF385B in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF395 (zinc finger protein 395) | Using a linear mixed model, differential expression with age was identified in ZNF395 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF439 (zinc finger protein 439) | Using a linear mixed model, differential expression with age was identified in ZNF439 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF451 (zinc finger protein 451) | Using a linear mixed model, differential expression with age was identified in ZNF451 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF471 (zinc finger protein 471) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ZNF471 and age. | Male and Female | 0 | 78 | Blood | 3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752) | ||
| ZNF502 (zinc finger protein 502) | Using a linear mixed model, differential expression with age was identified in ZNF502 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF507 (zinc finger protein 507) | Male and Female | 26 | 106 | Brain | 43.0 | <0.001 | 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254) | |
| ZNF514 (zinc finger protein 514) | Using a linear mixed model, differential expression with age was identified in ZNF514 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF518A (zinc finger protein 518A) | Using a linear mixed model, differential expression with age was identified in ZNF518A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF518B (zinc finger protein 518B) | Using a linear mixed model, differential expression with age was identified in ZNF518B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF524 (zinc finger protein 524) | Using a linear mixed model, differential expression with age was identified in ZNF524 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF529 (zinc finger protein 529) | Using a linear mixed model, differential expression with age was identified in ZNF529 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF536 (zinc finger protein 536) | Comparison of DNA methylation showed a significantly decreased methylation level of ZNF536 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | -19.1 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ZNF540 (zinc finger protein 540) | Using a linear mixed model, differential expression with age was identified in ZNF540 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF549 (zinc finger protein 549) | Comparison of DNA methylation showed a significantly increased methylation level of ZNF549 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) | Male and Female | 21 | 85 | Mesenchymal Stem Cell | 19.3 | None | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ZNF549 (zinc finger protein 549) | Comparison of DNA methylation showed a significantly increased methylation level of ZNF549 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) | Female | 6 | 73 | Dermis | 16.0 | <0.001 | 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436) |
| ZNF559 (zinc finger protein 559) | Using a linear mixed model, differential expression with age was identified in ZNF559 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF581 (zinc finger protein 581) | Using a linear mixed model, differential expression with age was identified in ZNF581 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF621 (zinc finger protein 621) | Using a linear mixed model, differential expression with age was identified in ZNF621 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF662 (zinc finger protein 662) | Using a linear mixed model, differential expression with age was identified in ZNF662 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF700 (zinc finger protein 700) | Using a linear mixed model, differential expression with age was identified in ZNF700 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF75D (zinc finger protein 75D) | Using a linear mixed model, differential expression with age was identified in ZNF75D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF770 (zinc finger protein 770) | Gene expression showed a significant (p<E-3) decrease in the expression of ZNF770 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) | Female | -1 | -1 | Ovary | -48.72 | <0.001 | 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335) |
| ZNF789 (zinc finger protein 789) | Using a linear mixed model, differential expression with age was identified in ZNF789 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF81 (zinc finger protein 81) | Using a linear mixed model, differential expression with age was identified in ZNF81 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF827 (zinc finger protein 827) | Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of ZNF827 and age. | Male and Female | 25 | 92 | Blood | 3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035) | ||
| ZNF83 (zinc finger protein 83) | Using a linear mixed model, differential expression with age was identified in ZNF83 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZNF839 (zinc finger protein 839) | Using a linear mixed model, differential expression with age was identified in ZNF839 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Znrd1 (zinc ribbon domain containing, 1) | Male and Female | 2 | 26 | Lung | -2.0 | <0.001 | 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092) | |
| ZP1 (zona pellucida glycoprotein 1 (sperm receptor)) | Using a linear mixed model, differential expression with age was identified in ZP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZSCAN2 (zinc finger and SCAN domain containing 2) | Using a linear mixed model, differential expression with age was identified in ZSCAN2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. | Female | 39 | 85 | Adipose Tissue | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZSWIM5 (zinc finger, SWIM-type containing 5) | Using a linear mixed model, differential expression with age was identified in ZSWIM5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZSWIM8 (zinc finger, SWIM-type containing 8) | Using a linear mixed model, differential expression with age was identified in ZSWIM8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| ZZEF1 (zinc finger, ZZ-type with EF-hand domain 1) | Using a linear mixed model, differential expression with age was identified in ZZEF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. | Female | 39 | 85 | Skin | 3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843) | ||
| Zzz3 (zinc finger, ZZ domain containing 3) | Male and Female | 5 | 25 | Skeletal Muscle | -12.0 | <0.001 | 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838) | |
| Reference:Digital Aging Atlas |