|
Antigen |
Other |
MW |
Structure |
Distribution |
Function |
| 4-1BB Ligand |
CD137L |
|
TNFSF |
Bact, DC, carcinoma cell lines |
T costimulation |
| AID |
|
|
RNA-editing deaminase family |
Bact, Germinal Center B |
Activation-Induced Deaminase, Ig class switch recombination |
| AITR |
TNFRSF18, GITR |
|
|
Treg, Tact |
costimulation |
|
AITRL |
TNFSF18, TL6, GITRL |
|
|
APC |
|
|
B7 family |
see CD273-276 |
|
|
|
|
| B7-H4 |
B7-S1, B7x |
|
B7 family |
|
may interact with BTLA (?), inhibition |
| BAMBI |
TGFBR |
29kD |
TGFBR |
carcinoma cell |
pseudoreceptor for TGF- b (short cytoplasmic domain), growth inhibition |
|
BCMA |
see CD269 |
|
|
|
|
| BLyS |
see CD257 |
|
|
|
|
| BR3 |
see CD268 |
|
|
|
|
| BTLA |
see CD272 |
|
|
|
|
| CCR7 |
see CD197 |
|
|
|
|
| c-Met |
HGFR/SFR |
190kD |
heterodimer, PTK |
epith, hematopoietic progenitors, early thymocytes |
tumor growth / metastasis, Hepatocyte Growth Factor / Scatter Factor receptor, T development, hematopoiesis |
| CMKLR1 |
chemokine-like receptor 1 |
42kD |
GPCR 7TM, chemokine receptor |
pDC (CD123+), in vitro derived moDC |
binds chemerin, pDC recruitment, bone development |
| DcR3 |
TR6, TNFRSF6B |
|
Soluble |
tumors |
Fas decoy receptor, tumor evasion |
|
|
|
|
|
|
|
| DEC-205 |
see CD205 |
|
|
|
|
| DR3 |
TRAMP, Apo-3, WSL-1, LARD, TR3 |
|
TNFRSF |
Tact, leukocytes |
lymphocyte homeostasis |
|
|
|
|
|
|
|
|
DR6 |
TR7 |
|
TNFRSF |
|
death, Th2 response |
| Fc epsilonRI alpha |
high-affinity IgE receptor |
|
tetramer complex |
mast cells, basophils |
triggers IgE-mediated allergic reactions |
| Foxp3 |
SCURFIN |
50kD |
Fox family forkhead |
T subsets (CD4+/CD25+ subset and CD8+ subset) |
transcription factor, upregulated in T regs |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Granzyme B |
Granzyme-2, CTLA-1 |
30kD |
Peptidase S1 family |
Cytotoxic T, NK |
target cell apoptotic lysis, cell-mediated immune responses |
| HLA-ABC |
|
45, 11-12kD |
|
nucleated cells |
cell-mediated immune response & tumor surveillance |
| HLA-DR |
|
|
|
APC, Tact |
presentation of peptides to CD4+ T lymphocytes |
| HVEM |
TNFRSF14, TR2 |
60kD |
TNFRSF |
broad expression |
receptor for LIGHT, LT-alpha, BTLA, Herpes Simplex Virus, lymphocyte activation |
| ICOS |
see CD278 |
|
|
|
|
| ICOSL |
see CD275 |
|
|
|
|
| IL-15R alpha |
|
|
|
monoact |
binds to IL-15, w/ IL-2RB and common gamma, IL-15 trans-presentation |
| Integrin b5 |
|
100kD |
|
carcinoma cell lines, fibroblast lines |
w/ alphav subunit, vitronectin receptor |
| MD-2 |
|
30KD |
|
w/ TLR4 distribution and LPS recognition |
|
| MICA/MICB |
|
70kD |
MHC Class I-related proteins |
intestinal epith, some tumors |
unregulated on epith after shock, NKG2D receptors |
| Nanog |
|
34kD |
|
ES cells |
transcription factor, self renewal of ES cells |
|
|
|
|
|
|
|
| NKG2D |
see CD314 |
|
|
|
|
| NOD2 |
CARD-15, IBD1 |
|
|
monocytes, intracellular |
|
| Notch-1 |
Lin-12, Tan 1 |
|
|
developing embryo, variety of adult tissues |
cell-cell interaction, cell fate determination |
| OPG |
TRAIL-R5, TR1, TNFRSF11B |
|
|
binds TRAIL? |
bone resorption |
| OX-40 |
see CD134 |
|
|
|
|
| OX-40 Ligand |
see CD252 |
|
|
|
|
| p38 |
|
38kD |
SAP/MAP kinase |
NK, CD8+ T subset, upregulated on CD8+T |
role in cytolytic activity |
| PD-1 |
see CD279 |
|
|
|
|
| PD-L1 |
see CD274 |
|
|
|
|
| PD-L2 |
see CD273 |
|
|
|
|
| Perforin |
|
70-75kD |
|
CTL, NK |
cytolytic protein |
|
|
|
|
|
|
|
| RP105 |
see CD180 |
|
|
|
|
| RANK |
see CD265 |
|
|
|
|
| RANKL |
see CD254 |
|
|
|
|
| SAP |
SLAM-associated protein |
14kD |
adaptor protein |
T, NK |
negatively regulates SLAM- family receptors |
| SLP-76 |
|
76kD |
|
T, Blow |
T cell receptor mediated signaling |
| SSEA-1 |
stage-specific embryonic antigen-1 |
|
|
ES cells, embryonic carcinomas, germ cells |
down regulated by differentiation |
| SSEA-3 |
stage-specific embryonic antigen-3 |
|
|
|
|
| SSEA-4 |
stage-specific embryonic antigen-4 |
|
|
|
|
|
Stro-1 |
|
|
|
BM stroma, erythroid progenitors |
surface marker for immature mesenchymal cells |
| TACI |
see CD267 |
|
|
|
|
| T-bet |
|
|
|
Th1 cells |
transcription factor, T development / differentiation |
| TCL1 |
|
|
|
B cell tumors, lymphoid lineages in a developmentally controlled manner, pDC |
intracellular, lymphoid proto-oncogene |
| TCR alpha b |
|
|
|
peripheral T subset |
antigen recognition |
| TCR gamma delta |
|
|
|
T subset |
antigen recognition |
|
TLR1 - TLR4 |
see CD281 - CD284 |
|
|
|
|
|
TLR5 |
TIL3 |
|
TLR family |
mRNA: leukocytes, prostate, ovary, liver, lung |
interacts w/ microbial lipoproteins, NF-kappaB, responds to Salmonella |
| TLR6 |
|
|
TLR family |
mRNA: leukocytes, ovary, lung |
interacts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response |
| TLR7 |
|
|
TLR family |
mRNA: spleen, placenta, lung; upregulated on mac |
|
|
TLR8 |
|
|
TLR family |
mRNA: leukocytes, lung |
|
| TLR9 |
see CD289 |
|
|
|
|
|
TLR10 |
|
|
TLR family |
mRNA: lymphoid tissues |
most closely related to TLR1 and TLR6 |
| TNFRI |
see CD120a |
|
|
|
|
| TRAIL |
see CD253 |
|
|
|
|
| TSLPR |
|
50kD |
heterodimer with IL-7Ralpha/CD127 |
monocytes, DC, B |
binds TSLP (Thymic Stromal Lymphopoietin) to activate DC |
| TWEAK |
TNFSF12, APO3L |
|
TNFSF |
activated mono |
death |
|
|
|
|
|
|
|
| TWEAK Receptor |
see CD266 |
|
|
|
|
|
ULBPs |
|
|
MHC class I-related protiens, GPI-linked |
tumors |
NKG2D receptors, NK activation |
| ZAP-70 |
TCRζ-associated kinase |
70kD |
Syk family |
Intracellular T, NK |
TCR signaling & development |