|
CD |
Other |
Molecular weight |
Structure |
Distribution |
Function |
| CD1a |
T6 |
49kD |
IgSF, MHC-like |
cortical thymocytes, Langerhans cells, DC |
antigen presentation, with b2m |
| CD1b |
T6 |
45kD |
IgSF, MHC-like |
cortical thymocytes, Langerhans cells, DC |
antigen presentation, with b2m |
| CD1c |
T6 |
43kD |
IgSF, MHC-like |
cortical thymocytes, Langerhans cells, DC, B subset |
antigen presentation, with b2m |
| CD1d |
|
49kD |
IgSF, MHC-like |
intestinal epith, B subset, monolow, DC |
antigen presentation, with b2m |
|
CD1e |
|
28kD |
IgSF, MHC-like |
DC |
antigen presentation, with b2m |
| CD2 |
T11, LFA-2, SRBC-R |
50kD |
IgSF |
thymocytes, T, NK |
CD58 ligand, adhesion, T cell activation |
|
CD2R |
T11-3 |
50kD |
IgSF |
Tact |
activation-dependent form of CD2 |
| CD3 gamma, CD3 delta |
T3 |
|
IgSF |
T, thymocyte subset |
with TCR, TCR surface expression / signal transduction |
| CD3 epsilon |
T3 |
20kD |
IgSF |
T, thymocyte subset |
with TCR, TCR surface expression / signal transduction |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CD4 |
T4 |
55kD |
IgSF |
thymocyte subset, T subset, mono, mac |
MHC class II coreceptor, HIV receptor, T cell differentiation / activation |
|
|
|
|
|
|
|
| CD5 |
T1, Tp67 |
67kD |
Scavenger R SF |
thymocytes, T, B subset, B-CLL |
CD72 receptor, TCR or BCR signaling, T-B interaction |
| CD6 |
T12 |
100-130kD |
Scavenger R SF |
thymocytes, T, B subset |
CD166 receptor, T cell differentiation / costimulation |
| CD7 |
|
40kD |
IgSF |
hematopoietic progenitors, thymocytes, T, NK |
T costimulation |
| CD8a |
T8, Leu-2 |
32-34kD |
IgSF |
thymocyte subset, T subset, NK |
MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation / activation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CD8b |
|
30-32kD |
IgSF |
thymocyte subset, T subset |
|
| CD9 |
p24, MRP-1 |
22-27kD |
TM4SF |
pre-B, eosinophils, basophils, platelets, Tact |
cellular adhesion and migration |
| CD10 |
CALLA, NEP, gp100 |
100kD |
type II TM |
B precursors, T precursors, neutrophils |
zinc-binding metalloproteinase, B cell development |
| CD11a |
LFA-1, integrin alphaL |
180kD |
Integrin family |
lymph, gran, mono, mac |
CD11a / CD18 receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation |
| CD11b |
Mac-1, integrin alphaM |
170kD |
Integrin family |
myeloid cells, NK |
binds CD54, ECM, iC3b |
|
|
|
|
|
|
|
| CD11c |
p150, 95, CR4, integrin alphaX |
150kD |
Integrin family |
DC, myeloid cells, NK, B, T subset |
binds CD54, fibrinogen and iC3b |
|
CD12 |
|
90-120kD |
|
mono, gran, platelets |
|
| CD13 |
Aminopeptidase N, APN |
150-170kD |
type II TM |
myeloid cells |
zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains |
| CD14 |
LPS-R |
53-55kD |
GPI-linked |
mono, mac, Langerhans cells, granlow |
receptor for LPS/LBP, LPS recognition |
| CD15 |
Lewis-x, Lex |
|
CHO |
neutrophils, eosinophils, mono |
adhesion |
|
CD15s |
Sialyl Lewis X |
|
CHO |
neutrophils, eosinophils, mono, memory helper T, Tact and B, NK, HEV |
CD62L and CD62P ligand, adhesion |
|
CD15u |
Sulfated Lewis X |
|
CHO |
myeloid subset |
adhesion |
| CD16a |
FcgammaRIIIA |
50-65kD |
IgSF |
neutrophils, mac, NK |
component of low affinity Fc receptor, phagocytosis and ADCC |
| CD16b |
FcgammaRIIIB |
48kD |
IgSF |
neutrophils |
component of low affinity Fc receptor, phagocytosis and ADCC |
|
CD17 |
|
|
|
neutrophils, mono, platelets |
lactosyl ceramide |
| CD18 |
Integrin b2 |
95kD |
Integrin family |
broad, all leukocytes |
with CD11a, b & c, adhesion |
| CD19 |
B4 |
95kD |
IgSF |
B, FDC |
complex with CD21 and CD81, BCR coreceptor, B cell activation / differentiation |
| CD20 |
B1, Bp35 |
33-37kD |
TM4SF |
B, T subset |
B cell activation |
| CD21 |
C3DR, CR2, EBV-R |
145,110kD |
CCRSF |
B, FDC, T subset |
complement C3d and EBV receptor, complex with CD19 and CD81, BCR coreceptor |
| CD22 |
BL-CAM, Siglec-2 |
150kD |
IgSF, sialoadhesins |
B |
adhesion, B-mono, B-T interactions |
| CD23 |
FcepsilonRII |
45kD |
C-type lectin |
B, activated mac, eosinophils, FDC, platelets |
CD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction |
| CD24 |
BA-1 |
35-45kD |
GPI-linked |
thymocytes, erythrocytes, peripheral lymph, myeloid |
binds P-selectin |
| CD25 |
Tac, p55 |
55kD |
type I TM |
Tact, Bact, lymph progenitors |
IL-2Ralpha, with IL-2R b and gamma to form high affinity complex |
| CD26 |
DPP IV |
110kD |
type II TM |
thymocyte subset, Tact, soluble form |
dipeptidyl peptidase, T costimulation, HIV entry |
| CD27 |
T14 |
50-55kD |
TNFRSF |
medullary thymocytes, T, B subset, NK subset |
CD70 receptor, T costimulation |
|
|
|
|
|
|
|
| CD28 |
Tp44, T44 |
44kD |
IgSF |
most T, thymocytes, plasma cells |
CD80, CD86 receptor, T costimulation |
|
|
|
|
|
|
|
| CD29 |
Integrin b1 |
130kD |
Integrin family |
lymph, mono, granlow, platelets, mast cells, fibroblasts, endoth |
with CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM |
| CD30 |
Ki-1 |
105-120kD |
TNFRSF |
Bact, T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma |
CD153 receptor, lymph proliferation / apoptosis |
| CD31 |
PECAM-1 |
130-140kD |
IgSF |
mono, platelets, gran, endoth, lymph subset |
CD38 receptor, adhesion |
| CD32 |
FcgammaRII |
40kD |
IgSF |
mono, gran, B, platelets |
low affinity Fc receptor for aggregated Ig and immune complexes |
| CD33 |
p67, Siglec-3 |
67kD |
IgSF, sialoadhesins |
myeloid progenitors, mono, gran, DC, mast cells, Tact |
adhesion |
|
|
|
|
|
|
|
| CD34 |
|
105-120kD |
Sialomucin, type I TM |
hematopoietic precursors, capillary endoth, embryonic fibroblasts |
stem cell marker, adhesion, CD62L receptor |
|
CD35 |
CR1 |
250kD |
CCRSF |
erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset |
complement receptor 1, binds C3b and C4b, adhesion, phagocytosis |
| CD36 |
GPIV |
88kD |
|
platelets, mono, mac, endoth, early erythrocytes |
ECM receptor, adhesion, phagocytosis |
|
CD37 |
|
40-52kD |
TM4SF |
B, Tlow, granlow |
signal transduction |
| CD38 |
T10 |
45kD |
|
variable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact |
ecto-ADP-ribosyl cyclase, cell activation |
| CD39 |
|
78kD |
NK, mac, Langerhans cells, DC, Bact |
B cell adhesion, protects activated cells from lysis, ecto-apyrase |
|
| CD40 |
|
48kD |
TNFRSF |
B, mono, mac, FDC, endoth, T subset |
CD154 receptor, B differentiation / costimulation, isotype-switching, rescues B cells from apoptosis |
| CD41 |
gpIIb |
125/22kD |
Integrin family |
platelets, megakaryocytes |
with CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation |
|
|
|
|
|
|
|
| CD42a |
GPIX |
22kD |
LRRF |
platelets, megakaryocytes |
complex with CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices |
| CD42b |
GPIba |
145kD |
LRRF |
platelets, megakaryocytes |
complex with CD42a, c and d, binds to vWF and thrombin, platelet adhesion / activation |
|
CD42c |
GPIbb |
24kD |
LRRF |
platelets, megakaryocytes |
complex with CD42a, b, d |
| CD42d |
GPV |
82kD |
LRRF |
platelets, megakaryocytes |
complex with CD42a-c |
| CD43 |
Leukosialin, sialophorin |
115-135kD |
Sialomucin, type I TM |
leukocytes, except resting B, plateletslow |
inhibition of T cell interaction, CD54R, adhesion |
| CD44 |
H-CAM, Pgp-1 |
80-95kD |
hyaladherin family |
hematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis |
binds hyaluronic acid, adhesion |
|
CD44R |
CD44v |
|
|
CD44 variants heterogeneous expression, constitutively on epith, mono, upregulated on activated leukocytes |
adhesion, metastasis |
| CD45 |
LCA, T200, B220 |
180-240kD |
|
hematopoietic cells, multiple isoforms from alternative splicing |
tyrosine phosphatase, enhanced TCR & BCR signals |
|
|
|
|
|
|
|
| CD45RA |
|
205-220kD |
|
B, T subset(naive), mono |
exon A isoforms of CD45 |
|
|
|
|
|
|
|
| CD45RB |
|
190-220kD |
|
T subset, B, mono, mac, gran |
exon B isoforms of CD45 |
| CD45RO |
|
180kD |
|
Tact, memory T, B subset, mono, mac, gran |
isoform of CD45 lacking A, B, C exons |
| CD46 |
MCP |
56/66kD |
CCRSF |
nucleated cells |
membrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor |
| CD47 |
IAP |
47-52kD |
IgSF |
hematopoietic cells, epith, endoth, fibroblasts, other tissues |
leukocyte adhesion, migration, activation |
|
CD47R |
|
|
|
New designation for CDw149, similar distribution as CD47 but dimmer |
|
| CD48 |
Blast-1 |
45kD |
IgSF |
broad, all leukocytes |
cell adhesion |
|
CD49a |
VLA-1 |
210kD |
Integrin family |
Tact, mono |
integrin alpha1, adhesion, CD49a/CD29 binds collagen and laminin |
| CD49b |
VLA-2 |
165kD |
Integrin family |
B, mono, platelets, Tact, megakaryocytes |
integrin alpha2, adhesion, CD49b / CD29 binds collagen and laminin |
| CD49c |
VLA-3 |
125kD |
Integrin family |
B and Tlow, most adhesive cell lines |
integrin alpha3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen |
| CD49d |
VLA-4 |
150kD |
Integrin family |
T, B, NK, thymocytes, mono, eosinophils, mast, DC |
integrin alpha4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1 |
| CD49e |
VLA-5 |
135, 25kD |
Integrin family |
thymocytes, T, mono, platelets, early and Bact |
integrin alpha5, adhesion, CD49e/CD29 binds fibronectin |
| CD49f |
VLA-6 |
125kD |
Integrin family |
memory T, thymocytes, mono, platelets, megakaryocytes, epith |
integrin alpha6, adhesion, CD49f / CD29 binds laminin |
| CD50 |
ICAM-3 |
110-120kD |
IgSF |
hematopoietic, endoth, epidermal Langerhans cells |
adhesion, costimulation |
| CD51 |
Vitronectin receptor |
125, 24kD |
Integrin family |
plateletslow, endoth, osteoblasts, melanomas |
integrin alphav, adhesion, CD51 / CD61 binds vitronectin, vWF, fibrinogen and thrombospondin |
|
CD52 |
CAMPATH-1 |
21-28kD |
|
thymocytes, T, B (not plasma cells), mono, mac |
|
|
CD53 |
|
35-42kD |
TM4SF |
leukocytes, DC, osteoblasts, osteoclasts |
signal transduction |
| CD54 |
ICAM-1 |
90-110kD |
IgSF |
endoth, mono, lymph (high upon activation) |
receptor for CD11a / CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus |
| CD55 |
DAF |
60-70kD |
GPI-linked |
hematopoietic, endoth |
binds C3b, complement regulation |
| CD56 |
NCAM |
175-185kD |
IgSF |
NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias |
adhesion |
| CD57 |
HNK-1, Leu-7 |
110kD |
|
NK subset, T subset |
|
| CD58 |
LFA-3 |
55-70kD |
IgSF |
hematopoietic, non-hematopoietic cells |
CD2 receptor, adhesion |
| CD59 |
Protectin, MAC- inhibitor |
19kD |
GPI-linked |
hematopoietic, non-hematopoietic cells |
binds complement C8 and C9, blocks assembly of membrane attack complex |
|
CD60a |
GD3 |
|
CHO |
T subset, platelets, thymic epith, astrocytes |
costimulation |
|
CD60b |
9-O-sialyl GD3 |
|
CHO |
T subset, Bact |
|
|
CD60c |
7-O-sialyl GD3 |
|
CHO |
T subset |
|
| CD61 |
GPIIIa |
105kD |
Integrin family |
platelets, megakaryocytes, mac, endoth |
integrin b3, adhesion, CD41/CD61 or CD51 / CD61 mediate adhesion to ECM |
| CD62E |
E-selectin, ELAM-1 |
97,107-115kD |
Selectin family |
endoth |
binds CD15s, cell rolling, metastasis |
| CD62L |
L-selectin, LECAM-1 |
74, 95kD |
Selectin family |
B, naïve and memory T, mono, gran, NK, thymocytes |
CD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling |
| CD62P |
P-selectin, PADGEM |
140kD |
Selectin family |
activated platelets, endoth |
CD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions |
|
CD63 |
LIMP, LAMP-3 |
53kD |
TM4SF |
activated platelets, mono, mac |
lysosomal membrane protein, moves to cell surface after activation |
| CD64 |
FcgammaRI |
72kD |
IgSF |
mono, mac, DC, Interferon or G-CSF activated gran |
high affinity receptor for IgG, phagocytosis and ADCC |
| CD65 |
|
|
|
gran, mono subset, myeloid leukemias |
|
|
CD65s |
VIM2 |
|
|
gran, mono, myeloid leukemias |
phagocytosis |
| CD66a |
BGP-1, NCA-160 |
160-180kD |
IgSF, CEA family |
neutrophils, epith |
cell adhesion |
|
CD66b |
CD67, CGM6 |
95-100kD |
IgSF, CEA family |
gran |
cell adhesion, neutrophil activation |
|
CD66c |
NCA |
90kD |
IgSF, CEA family |
neutrophils, colon carcinoma |
cell adhesion |
|
CD66d |
CGM1 |
35kD |
IgSF, CEA family |
neutrophils |
|
| CD66e |
CEA |
180-200kD |
IgSF, CEA family |
colon epith, colon cancer |
cell adhesion |
|
CD66f |
PSG, Sp-1 |
54-72kD |
IgSF, CEA family |
pregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver |
immune regulation, protects fetus from maternal immune system |
| CD68 |
Macrosialin, gp110 |
110kD |
Sialomucin |
intracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver |
|
| CD69 |
AIM |
28, 32kD |
C-type lectin |
Tact, B, NK and gran, thymocytes, platelets, Langerhans cells |
signal transduction |
| CD70 |
Ki-24 |
50, 70, 90, 160kD |
TNFSF |
Bact and Tact |
CD27 ligand, T and B cell costimulation |
| CD71 |
T9 |
95kD |
|
proliferating cells, reticulocytes, erythroid precursors |
transferrin receptor, iron uptake |
|
|
|
|
|
|
|
|
CD72 |
Lyb-2 |
42kD |
C-type lectin |
B, FDC |
CD5, CD100 receptor, B proliferation |
| CD73 |
|
69kD |
GPI-linked |
B subset, T subset, FDC, epith |
ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion |
| CD74 |
Ii, invariant chain |
33, 35, 41, 43kD |
|
B, mac, mono, Langerhans cells, DC, Tact |
MHC class II traffic and function |
|
CD75 |
|
|
CHO Sialoglycan family |
B subset, epith |
lactosamines |
|
CD75s |
|
|
CHO Sialoglycan family |
B subset, T subset |
alpha-2,6-sialylated lactosamines (previously CDw75 and CDw76) |
|
CD77 |
Gb3, Pk blood group |
|
|
germinal center B, Burkitt’s lymphomashigh, follicular lymphomaslow |
apoptosis |
| CD79a |
Iga |
33, 45kD |
IgSF |
B |
component of BCR, BCR surface expression and signal transduction |
| CD79b |
Igb |
37kD |
IgSF |
B |
component of BCR, BCR surface expression and signal transduction |
| CD80 |
B7, B7-1, BB1 |
60kD |
IgSF |
Bact and Tact, mac, DC |
binds to CD28, CD152, T costimulation |
| CD81 |
TAPA-1 |
26kD |
TM4SF |
T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas |
complex with CD19 & CD21, signaling, T costimulation |
| CD82 |
R2 |
50-53kD |
TM4SF |
leukocytes |
signal transduction |
| CD83 |
HB15 |
43kD |
IgSF |
Bact and Tact, DC, Langerhans cells |
|
|
CDw84 |
|
73kD |
|
mono, platelets, B, T subset, mac subset |
|
|
CD85 |
|
110kD |
IgSF, ILT/LIR family |
DC, mono, B, NK, T subset |
inhibition of NK, T cell cytolytic function |
| CD86 |
B70, B7-2 |
80kD |
IgSF |
mono, DC, Bact and Tact |
binds to CD28, CD152, T costimulation |
| CD87 |
UPA-R |
39-66kD |
GPI-linked |
gran, mono, NK, Tact, endoth, fibroblasts |
urokinase plasminogen activator receptor, inflammatory cell invasion, metastasis |
|
CD88 |
C5aR |
40kD |
TM7SF |
gran, mono, DC |
C5a receptor, granulocyte activation |
|
CD89 |
FcalphaR |
55-75kD |
IgSF |
mono, mac, gran, neutrophils, B subset, T subset |
IgA receptor, phagocytosis, degranulation, respiratory burst |
| CD90 |
Thy-1 |
25-35kD |
IgSF, GPI-linked |
CD34+ hematopoietic subset, neurons |
hematopoietic stem cell and neuron differentiation |
|
CD91 |
|
600kD |
LDLR family |
mono, mac, neurons, fibroblasts |
receptor for alpha-2-macroglobulin |
|
CD92 |
|
70kD |
|
neutrophils, mono, platelets, endoth, fibroblasts |
|
| CD93 |
|
120kD |
|
neutrophils, mono, endoth |
|
| CD94 |
KP43 |
43kD |
C-type lectin |
NK, T subset |
complex with NKG2, inhibits NK function |
| CD95 |
Apo-1, Fas |
45kD |
TNFRSF |
lymph (high upon activation), mono, neutrophils |
FasL (CD178) receptor, apoptosis |
|
|
|
|
|
|
|
| CD96 |
TACTILE |
160kD |
IgSF |
NK, Tact |
adhesion of activated T and NK |
| CD97 |
|
74, 80, 90kD |
TM7SF |
Bact and Tact, mono, gran |
|
| CD98 |
4F2 |
80, 40kD |
|
T, B, NK, gran, all human cell lines |
cellular activation |
| CD99 |
MIC2, E2 |
32kD |
|
leukocytes |
T cell activation, adhesion |
|
CD99R |
E2 |
32kD |
|
T, NK, myeloid cells |
isoform of CD99 |
| CD100 |
|
150kD |
|
hematopoietic cells except immature bone marrow cells, RBC and platelets |
cell adhesion, cellular activation |
| CD101 |
V7, p126 |
120kD |
IgSF |
mono, gran, DC, Tact |
T cell activation |
| CD102 |
ICAM-2 |
55-65kD |
IgSF |
lymph, mono, platelets, endoth |
binds CD11a / CD18, costimulation |
| CD103 |
HML-1, alpha6, integrin alphaE |
150, 25kD |
Integrin family |
intraepithelial lymph, lymph subset, activated lymph |
with integrin b7, binds E-cadherin, lymph homing/retention |
| CD104 |
b 4 integrin |
220kD |
Integrin family |
epith, Schwann cells, keratinocytes, some tumor cells |
with integrin alpha6 (CD49f), cell adhesion, differentiation, metastasis |
| CD105 |
Endoglin |
95kD |
homodimer |
endoth, bone marrow subset, activated mac |
cellular response to TGF- b1 |
| CD106 |
VCAM-1 |
110kD |
IgSF |
activated endoth, FDC |
VLA-4 (CD49d / CD29) receptor, leukocyte adhesion, migration, costimulation |
| CD107a |
LAMP-1 |
110kD |
|
activated platelets, T, endoth, metastatic tumors |
a lysosomal membrane protein |
| CD107b |
LAMP-2 |
120kD |
|
activated platelets, T, endoth, metastatic tumors |
a lysosomal membrane protein |
|
CD108 |
|
80kD |
|
erythrocytes, lymphoblasts, resting lymphlow |
|
| CD109 |
|
170kD |
|
Tact and platelets, CD34+ subset, endoth |
|
|
CD110 |
MPL, TPO-R |
82-84kD |
CRSF |
megakaryocytes, platelets, some CD34+ stem cellslow |
thrombopoietin receptor, megakaryocyte progenitor cell growth / differentiation |
|
CD111 |
PRR1, Nectin-1 |
64-72kD |
IgSF |
stem cell subset, mac, neutrophils |
|
| CD112 |
PRR2, Nectin-2 |
64-72kD |
IgSF |
mono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith |
intercellular adhesion |
|
CD113 |
PVRL3, Nectin3 |
83kD |
IgSF |
testis, placenta |
adhesion molecule that interacts with afadin |
|
CD114 |
G-CSFR |
95, 139kD |
CRSF |
myeloid progenitors, endoth |
myeloid differentiation / proliferation |
| CD115 |
M-CSFR, c-fms |
150kD |
IgSF, RTK family |
mono, mac, monocytic progenitors |
CSF-1R, monocytic differentiation / proliferation |
| CD116 |
GM-CSFRalpha |
70-85kD |
CRSF |
mono, gran, DC, endoth |
with common b, myeloid differentiation / proliferation |
| CD117 |
c-kit, SCFR |
145kD |
IgSF, RTK family |
hematopoietic progenitors, mast cells |
SCF receptor, hematopoietic progenitor development / differentiation |
|
CD118 |
LIFR, gp190 |
190kD |
Type I CRSF & secreted forms |
epithelial cells in adult and embryo |
membrane-bound involved in signal transduction, soluble form inhibits activity of LIF |
| CD119 |
IFNgammaR |
90-100kD |
|
mac, mono, B, T, NK, neutrophils, endoth |
IFN-gamma Ralpha, with IFN-gamma AF-1, host defense |
| CD120a |
TNFR-I |
50-60kD |
TNFRSF |
hematopoietic, non-hematopoietic cells |
receptor for both TNF-alpha and TNF- b |
| CD120b |
TNFR-II |
75-85kD |
TNFRSF |
hematopoietic, non-hematopoietic cells |
receptor for both TNF-alpha and TNF- b |
|
CD121a |
IL-1R type I |
80kD |
IgSF |
dimly expressed on many cells |
binds IL-1alpha and IL-1 b, IL-1 signaling |
|
CD121b |
IL-1R, type II |
60-70kD |
IgSF |
B, mac, mono, T subset |
binds IL-1alpha and IL-1 b, negative signals |
| CD122 |
IL-2R b |
75kD |
CRSF |
NK, T, B, mono |
IL-2R b and IL-15Rb, signal transduction |
| CD123 |
IL-3R |
70kD |
CRSF |
lymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes |
IL-3Ralpha, with CDw131 |
| CD124 |
IL-4R |
140kD |
CRSF |
lymphlow, mono, hematopoietic precursors, .broblast, epith |
IL-4Ralpha, with CD132 or IL-13Ralpha, T cell growth / differentiation |
|
CD125 |
IL-5R |
60kD |
CRSF |
eosinophils, basophils |
IL-5Ralpha, with CDw131 |
| CD126 |
IL-6R |
80kD |
IgSF, CRSF |
Bact and plasma cells, most leukocyteslow, fibroblasts |
IL-6Ralpha, with CD130 |
| CD127 |
IL-7R |
65-75kD |
CRSF |
T, pro-B |
IL-7Ralpha, with CD132, B and T cell development |
|
CD128 |
see CD181 & CD182 |
|
|
|
|
| CD130 |
IL-6R b, gp130 |
130kD |
CRSF |
Bact and plasma cells, most leukocyteslow, endoth |
IL-6R b, IL-6, IL-11, LIF, CNF signals |
| CD131 |
IL-3R common b |
95-120kD |
CRSF |
mono, gran, early B |
with alpha subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction |
| CD132 |
Common gamma |
64kD |
CRSF |
T, B, NK, mono, gran |
subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction |
| CD133 |
AC133, prominin-like 1 |
120kD |
TM5SF |
hematopoietic stem cell subset, epith, endoth |
|
| CD134 |
OX-40 |
48-50kD |
TNFRSF |
Tact |
T cell activation, differentiation, apoptosis |
| CD135 |
Flt3/Flk2 |
130-150kD |
RTK family |
myelomonocytic, primitive B progenitors |
tyrosine kinase, binds FLT3 ligand, early lymph development |
|
CD136 |
MSP-R, RON |
180kD |
RTK family |
epith, CNS, PNS, hematopoietic subset |
migration, morphological change and proliferation of different target cells |
| CD137 |
4-1BB |
30kD |
TNFRSF |
Tact |
T costimulation |
| CD138 |
Syndecan-1 |
80-150kD |
Syndecan family |
plasma cells, pre-B, basolateral surface of epith, meurons |
receptor for ECM, cell morphology |
|
CD139 |
|
228kD |
|
B, mono, gran, erythrocyteslow |
|
| CD140a |
PDGFRalpha |
180kD |
RTK family |
fibroblasts, smooth muscle & glial cells, chondrocytes |
binds PDGF A and B |
| CD140b |
PDGFR b |
180kD |
RTK family |
fibroblasts, smooth muscle & glial cells, chondrocytes |
binds PDGF B |
|
CD141 |
Thrombomodulin |
100kD |
C-type lectin |
mono, neutrophils, endoth, smooth muscle cells |
initiation of protein C anticoagulant signal |
|
CD142 |
Tissue Factor |
45kD |
|
mono, endoth, keratinocytes, epith |
binds clotting factor VIIa, initiator of clotting |
|
CD143 |
ACE |
170kD |
|
endoth, epith, neurons, fibroblasts, activated mac |
angiotensin converting enzyme, angiotensin II & bradykinin metabolism |
| CD144 |
VE-Cadherin, Cadherin-5 |
130kD |
Cadherin family |
endoth |
adhesion, cell-cell interaction |
|
CD145 |
|
110, 90kD |
|
endoth, some stromal cells |
|
| CD146 |
MUC18, S-endo |
113-118kD |
IgSF |
endoth, melanomas, FDC, Tact |
adhesion |
| CD147 |
Neurothelin, basoglin |
|
IgSF |
leukocytes, erythrocytes, platelets, endoth |
adhesion |
| CD148 |
HPTP-eta |
240-260kD |
|
gran, mono, DC, T (high upon activation) |
tyrosine phosphatase R Type III |
| CD150 |
SLAM |
75-95kD |
IgSF |
T subset (high upon activation), B, DC, endoth |
costimulation, proliferation, Ig production, measles virus receptor |
| CD151 |
PETA-3 |
32kD |
|
endoth, megakaryocytes, platelets, epith |
cell adhesion |
| CD152 |
CTLA-4 |
33kD |
IgSF |
Tact and B |
CD80 and CD86 receptor, negative regulation of T cell costimulation |
|
|
|
|
|
|
|
| CD153 |
CD30L |
40kD |
TNFSF |
neutrophils, B, Tact and mac |
CD30 ligand, T costimulation |
| CD154 |
CD40L, gp39, TRAP |
32-39kD |
TNFSF |
Tact |
CD40 ligand, B and DC costimulation |
| CD155 |
PVR |
80-90kD |
IgSF |
mono, mac, CD34+ thymocytes |
Polio virus receptor (PVR) |
|
CD156a |
ADAM8 |
69kD |
|
neutrophils, mono |
leukocyte extravasation |
|
CD156b |
TACE / ADAM 17 |
100kD |
|
broad |
cleaves membrane proteins (TNF, TGFalpha) to generate soluble forms |
|
CD156c |
ADAM10 |
98kD |
Peptidase M12B family |
lymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver |
proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP and ephrin-A2 |
| CD157 |
BST-1 |
42-45kD |
|
gran, mono, B progenitors, endoth |
ADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth |
|
CD158a |
p58.1 |
50-58kD |
IgSF, KIR family |
NK subset, T subset |
inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor |
|
CD158b |
p58.2 |
50-58kD |
IgSF, KIR family |
NK subset, T subset |
inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor |
|
CD159a |
NKG2A |
43kD |
|
T subset, NK |
with CD94, NK cell receptor |
|
CD159c |
NKG2C |
40kD |
Type II C-Type Lectin |
NK |
with MHC class I HLA-E molecules, forms heterodimer with CD94 |
| CD160 |
BY55 |
27kD |
IgSF |
NK subset, T subset |
costimulation |
| CD161 |
NKR-P1A |
40kD |
C-type lectin |
T subset, NK |
NK cell-mediated cytotoxicity |
| CD162 |
PSGL-1 |
120kD |
Mucin family |
mono, gran, most lymph |
CD62P, CD62L ligand, adhesion, rolling |
|
CD162R |
PEN-5 |
|
CHO |
NK subset |
|
| CD163 |
130kD |
|
Scavenger receptor SF |
mono, mac |
|
|
CD164 |
MGC-24 |
80kD |
epith, mono, lymphlow, bone marrow stromal cells, CD34+ erythroid progenitors |
hematopoietic progenitor cell-stromal cell interaction |
|
|
CD165 |
AD2, gp37 |
42kD |
lymph subset, mono, immature thymocytes, platelets |
adhesion, thymocyte-thymic epith interaction |
|
| CD166 |
ALCAM |
105kD |
IgSF |
neurons, mono, epith, fibroblasts, Tact |
CD6 ligand, adhesion |
|
CD167a |
DDR1 |
120kD |
RTK family |
epith, myoblasts |
tyrosine kinase, adhesion to collagen |
|
CD168 |
RHAMM |
84-88kD |
|
mono, T subset, thymocyte subset, intracellularly in breast cancer cells |
adhesion, tumor migration, metastasis |
| CD169 |
sialoadhesin, Siglec-1 |
185kD |
IgSF, sialoadhesins |
tissue mac subset |
adhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells |
|
CD170 |
Siglec-5, CD33-like2 |
140kD |
IgSF, sialoadhesins |
Mac subset, neutrophils |
adhesion |
| CD171 |
L1 |
200-210kD |
IgSF |
CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells |
kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins |
| CD172a |
SIRPgamma |
110kD |
|
mono, T subset, stem cells |
adhesion, complex with CD47 |
|
CD172b |
SIRP b, SIRB1 |
50kD |
IgSF |
mono and DC |
negative regulation of RTK-coupled signaling |
|
CD172g |
SIRPgamma, SIRPB2 |
45-50kD |
IgSF, ASV |
mRNA: liver and at lower levels in many tissues |
binds CD47 |
|
CD173 |
Blood group H type 2 |
|
CHO |
erythrocytes, stem cell subset, platelets |
|
|
CD174 |
Lewis Y |
|
CHO |
stem cells subset, epith |
|
|
CD175 |
Tn |
|
CHO |
stem cells subset |
|
|
CD175s |
Sialyl-Tn |
|
CHO |
erythroblasts |
|
|
CD176 |
Thomson Friedrenreich Ag |
|
CHO |
stem cell subset |
|
| CD177 |
NB1 |
56-62kD |
|
neutrophil subset |
|
| CD178 |
FasL, CD95L |
38-42kD |
TNFSF |
Tact, testis |
CD95 ligand, apoptosis, immune privilege, soluble form in serum |
|
CD179a |
V pre B |
16-18kD |
IgSF |
Pro- and Pre-B |
B cell differentiation / signaling, with IgM |
|
CD179b |
Lambda 5 |
22kD |
IgSF |
Pro- and Pre-B |
B cell differentiation / signaling, with IgM |
| CD180 |
RP-105 |
95-105kD |
LRRF, TLR family |
B subset, mono, DC |
B cell activation, LPS signaling, with MD-1 |
| CD181 |
CXCR1, IL-8RA |
39kD |
GPCR1 family |
neutrophils, basophils, NK, T subset, mono |
binding of IL-8 induces chemotaxis of neutrophils |
| CD182 |
CXCR2, IL-8RB |
40kD |
GPCR1 family |
neutrophils, basophils, NK, T subset, mono |
binding of IL-8 induces chemotaxis of neutrophils |
| CD183 |
CXCR3 |
40kD |
TM7SF |
eosinophils, Tact and NK, GM-CSF activated CD34+ progenitors |
IP-10 , Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response |
| CD184 |
CXCR4, fusin |
45kD |
TM7SF |
B, DC, T subset, mono, endoth |
SDF-1 receptor, X4 HIV-1 coreceptor |
|
CD185 |
CXCR5, BLR1 |
45kD |
GPCR1 family |
mature B and Burkitt Lymphoma cells |
with chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B |
|
CD186 |
CXCR6, BONZO |
40kD |
GPCR1 family |
Tact |
receptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1 |
|
CD191 |
CCR1, MIP-1alphaR, RANTES-R |
39kD |
GPCR1 family |
T, mono, stem cell subset |
binds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels |
|
CD192 |
CCR2, MCP-1-R |
40kD |
GPCR1 family |
activated NK and mononuclear phagocytes, T subset, B, endoth |
binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection |
| CD193 |
CCR3, CKR3 |
45kD |
GPCR1 family |
eosinophils, lower expression in neutrophils and mono, T subset |
binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1delta, alternative coreceptor with CD4 for HIV-1 infectiongg |
| CD195 |
CCR5 |
45kD |
|
mono, T subset |
MIP-1alpha, MIP-1 b and RANTES receptor, R5 HIV-1 coreceptor |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CD196 |
CCR6, LARC receptor, DRY6 |
45kD |
GPCR1 family |
T subset, B, DC subset |
binds MIP-3alpha/LARC |
| CD197 |
CCR7 |
45kD |
|
T subset, DC Subset |
6Ckine and MIP-2 b receptor |
|
CD198 |
CCR8, GPRCY6, TER1 |
50kD |
GPCR1 family |
T, high expression in Th2, NK, mono |
allergic inflammation, alternative coreceptor with CD4 for HIV-1 infection |
| CD199 |
CCR9, GPR-9-6 |
43kD |
GPCR1 family |
subset of memory T, lamina propria mononuclear cells |
binds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection |
| CD200 |
OX-2 |
45-50kD |
|
thymocytes, endoth, B, Tact |
inhibition of immune response |
| CD201 |
EPC-R |
50kD |
|
endoth subset |
activated protein C receptor |
| CD202b |
Tie2, Tek |
150kD |
RTK family |
stem cells, endoth |
angiopoietin-1 receptor |
|
CD203c |
NPP3 / PDNP3, ENpp1, PD-1b |
130-150kD |
type II TM |
basophils, mast cells, glioma cells, megakaryocytes |
ectoenzyme, binding to and clearance of extracellular nucleotides |
|
CD204 |
Macrophage scavenger-R |
220kD |
|
mac |
endocytosis of macromolecules |
| CD205 |
DEC-205 |
205kD |
|
DC, thymic epith |
DC, thymic epith |
| CD206 |
macrophage mannose-R |
180kD |
|
DC subset, mac, mono |
phagocytosis and pinocytosis of mannose containing molecules |
| CD207 |
Langerin |
40kD |
|
Langerhans cells |
endocytic receptor |
|
CD208 |
DC-LAMP |
70-90kD |
|
DCact, interdigitating DC |
|
| CD209 |
DC-SIGN |
44kD |
|
DC subset |
ICAM-3 receptor, HIV-1 binding protein |
|
|
|
|
|
|
|
|
CD210 |
IL-10-R |
90-110kD |
|
T, B, NK, mono, mac |
IL-10 receptor, signal transduction |
|
CD212 |
IL-12-R b1 |
100kD |
|
Tact and NK |
binds IL-12 with high affinity, associates with IL-12 receptor b2 |
| CD213a1 |
IL-13-R alpha1 |
65kD |
|
B, mono, fibroblasts, endoth |
binds IL-13 with low affinity, with CD124 |
|
CD213a2 |
IL-13-R alpha2 |
65kD |
|
B, mono |
binds IL-13 with high affinity |
| CD217 |
IL-17-R |
120kD |
|
broad |
IL-17 receptor |
| CD218a |
IL-18Ralpha, IL-1Rrp |
70kD |
IL-1R family |
T, NK, DCs |
binds IL-18, activation of NF-kappaB |
|
CD218b |
IL-18R b, IL18RAP |
70kD |
IL-1R family |
T, NK and DCs |
heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding |
|
CD220 |
Insulin-R |
140, 70kD |
|
broad |
insulin receptor |
| CD221 |
IGF-1 R |
140, 70kD |
|
broad |
binds IGF with high affinity, signaling, cell proliferation/ differentiation |
|
CD222 |
IGF-II R, mannose-6 phosphate-R |
250kD |
Type I TM |
broad, 90-95% intracellular |
adhesion, tumor growth, a receptor for TGF b-LAP, plasminogen, proliferin, truncated form (220kD) found in serum |
| CD223 |
LAG-3 |
70kD |
IgSF |
Tact and NK |
an MHC class II ligand |
|
CD224 |
GGT |
27, 68kD |
|
leukocytes, stem cells |
|
|
CD225 |
Leu-13 |
17kD |
|
broad |
|
| CD226 |
DNAM-1, PTA-1, TLiSA1 |
65kD |
IgSF |
T, NK, mono, platelets, activated HUVEC |
activation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum |
| CD227 |
MUC1, EMA |
300kD |
Mucin family, type I TM |
epith, stem cell subset, FDC, mono, B subset, some myelomas |
adhesion, signaling, binds CD169, CD54, & selectins |
|
CD228 |
Melanotransferrin |
80-95kD |
|
stem cells, melanomas |
|
| CD229 |
Ly-9 |
95, 110kD |
IgSF |
T, B |
adhesion |
| CD230 |
Prion protein |
35kD |
broad |
|
|
|
CD231 |
TALLA-1, A15 |
30-45kD |
TM4SF |
T leukemias, neuroblastomas, brain neurons |
marker for T cell acute lymphoblastic leukemia |
|
CD232 |
VESP-R |
200kD |
|
broad |
|
|
CD233 |
Band 3, SLC4A1 |
90kD |
Anion exchanger family |
erythrocytes |
anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton |
|
CD234 |
Duffy, DARC |
35-45kD |
|
erythrocytes |
Duffy antigen chemokine receptor |
| CD235a |
Glycophorin A |
36kD |
|
erythrocytes |
|
|
CD235ab |
Glycophorin A/B |
20kD |
|
erythrocytes |
|
|
CD235b |
Glycophorin B |
20kD |
|
erythrocytes |
|
|
CD236 |
Glycophorin C/D |
32, 23kD |
|
erythrocytes, stem cell subset |
|
|
CD236R |
Glycophorin C |
32kD |
|
erythrocytes, stem cell subset |
|
|
CD238 |
Kell |
93kD |
|
erythrocytes, stem cell subset |
|
|
CD239 |
B-CAM |
78-85kD |
|
erythrocytes, stem cell subset |
|
|
CD240CE |
Rh30CE |
30-32kD |
|
erythrocytes |
|
|
CD240D |
Rh30D |
30-32kD |
TM12SF |
erythrocytes |
|
|
CD241 |
RhAg, Rh50 |
50kD |
TM12SF |
erythrocytes |
complex with CD47, LW, glycophorin B |
|
CD242 |
ICAM-4 |
42kD |
IgSF |
erythrocytes |
adhesion, Landsteiner-Wiener blood group |
| CD243 |
MDR-1, p170, P-gp |
180kD |
|
stem cells, small intestine, kidneystem cells, small intestine, kidney |
ion pump |
| CD244 |
2B4 |
70kD |
type II TM |
T subset, mono, basophils, NK |
NK activation, CD48 ligand |
|
|
|
|
|
|
|
|
CD245 |
p220/240 |
220-240kD |
|
T subset |
|
|
CD246 |
ALK, Ki-1 |
80kD |
|
anaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph |
brain development, implicated in ALK lymphomas |
| CD247 |
TCRz |
16kD |
RTK family |
T, NK |
TCR complex subunit, coupling of antigen recognition to signaling |
|
CD248 |
TEM1, Endosialin |
175kD |
C-Type Lectin |
endothelial tissue, stromal fibroblasts |
tumor progression and angiogenesis |
|
CD249 |
Aminopeptidase A |
160kD |
Peptidase M1 family |
epith, endoth |
renin-angiotensin system |
| CD252 |
OX-40Ligand, gp34 |
34kD |
TNFSF |
Bact, cardiac myocytes |
T costimulation |
| CD253 |
TRAIL, Apo-2L, TL2, TNFSF10 |
|
TNFSF |
Tact, many tissues |
death |
|
|
|
|
|
|
|
| CD254 |
TRANCE, RANKL, OPGL |
35kD |
TNFSF |
lymph node & BM stroma Tact |
binds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation |
|
|
|
|
|
|
|
|
CD256 |
APRIL, TALL-2 |
16kD |
TNFSF |
mono, mac |
binds TACI & BCMA, B proliferation |
| CD257 |
BLyS, BAFF, TALL-1 |
|
TNFSF |
monoact, soluble form |
B cell growth factor & costimulator of Ig production |
|
|
|
|
|
|
|
| CD258 |
LIGHT, HVEM-L |
28kD |
TNFSF |
Tact, immature DC |
binds LTBR, T proliferation, receptor for HVEM |
| CD261 |
TRAIL-R1, DR4 |
57kD |
TNFRSF |
Tact, peripheral blood leukocytes |
contains death domain, apoptosis via FADD & caspase-8 |
|
|
|
|
|
|
|
| CD262 |
TRAIL-R2, DR5 |
60kD |
TNFRSF |
widely expressed, peripheral blood lymphocytes |
contains death domain, apoptosis via FADD and caspase-8 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CD263 |
TRAIL-R3, DcR1, LIT |
65kD |
TNFRSF |
peripheral blood lymphocytes |
receptor for TRAIL but lacks death domain |
|
|
|
|
|
|
|
| CD265 |
RANK, TRANCE-R, ODFR |
97kD |
TNFRSF |
broad expression |
binds TRANCE, osteoclastogenesis, T-DC interactions |
| CD266 |
TWEAK-R, FGF-inducible 14 |
14kD |
TNFRSF |
heart, placenta and kidney, HUVEC |
TWEAK receptor, cell-matrix interactions and endoth growth and migration |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CD267 |
TACI, TNFR SF13B |
|
|
B, Tact |
binds BAFF & APRIL |
|
|
|
|
|
|
|
| CD268 |
BAFFR, TR13C |
25kD |
TNFRSF |
B |
binds BLyS, mature B survival |
|
|
|
|
|
|
|
|
CD269 |
BCMA, TNFRSF13B |
20kD |
TNFRSF |
mature B (membrane and perinuclear) |
APRIL & BAFF receptor, B survival & proliferation |
|
CD271 |
NGFR, p75 (NTR) |
45kD |
TNFRSF |
neurons (schwann cells, growing neurites), BM mesencymal cells |
NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death |
| CD272 |
BTLA |
33kD |
IgSF |
Tact, B , remains on Th1 |
HVEM receptor, inhibitory response |
| CD273 |
B7DC, PD-L2, PDCD1L2 |
25kD |
IgSF |
DC subset, mono, mac |
PD-1 receptor, costimulation or suppression of T proliferation |
| CD274 |
B7-H1, PD-L1 |
33kD |
IgSF |
leukocytes, broad |
PD-1 receptor, costimulation of lymphocytes |
| CD275 |
B7-H2, ICOSL, B7-RP1, GL50 |
60kD |
B7 Family |
B, DC, mono |
costimulation, cytokine production |
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| CD276 |
B7-H3 |
40-45kD |
B7 Family, ASV |
in vitro cultured DC and mono, Tact, mammary tissue |
costimulation, T activation |
| CD277 |
BT3.1, butyrophilin SF3 A1, BTF5 |
56kD |
B7/BT family, ASV |
T, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines |
T activation |
| CD278 |
ICOS, AILIM |
55-60kD |
CD28 family |
Tact, Th2 |
binds ICOS-L, T costimulation |
| CD279 |
PD1, SLEB2 |
55kD |
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Tact and Bact |
B7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance |
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CD280 |
ENDO180, UPARAP |
180kD |
C-type lectin SF |
chondrocytes, fibroblasts, endothelial, mac |
mannose receptor, collagen matrix remodeling and endocytic recycling |
| CD281 |
TLR1 |
90kD |
TLR family |
low levels in PBMC, mono and possibly DC |
innate immunity, with TLR2 |
| CD282 |
TLR2 |
90kD |
TLR family |
mono, neutrophil, upregulated in mac |
binds dsRNA, response to bacterial lipoproteins, innate immunity |
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| CD283 |
TLR3 |
100kD |
TLR family, ASV |
derived moDC (may be intracellular) |
binds dsRNA, innate immunity |
| CD284 |
TLR4 |
100kD |
TLR family, ASV |
PBMC (weak in mono, immature DC & neutro) |
binds LPS, innate immunity |
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| CD289 |
TLR9 |
120kD |
TLR family |
pDC (intracellular) |
binds CpG-DNA, innate immunity |
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CD292 |
BMPR1A, ALK3 |
57kD |
Type I |
bone progenitor |
BMP 2 & 4 receptor, bone development |
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CD293 |
BMPR1B, ALK6 |
57kD |
Type I, ASV |
bone progenitor |
BMP receptor, bone development |
| CD294 |
CRTH2. GPR44 |
55-70kD |
GPCR-7TM |
Th2, eosinophils, basophils |
binds prostaglandin D2, stimulatory effects on Th2, allergic inflammation |
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CD295 |
LeptinR, LEPR |
132kD |
Type I cytokine-like receptor |
broad |
adipose metabolism, immune dysfunction in obesity |
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CD296 |
ART1, RT6, ART2 |
37kD |
ADP- ribosyltransferase |
heart and skeletal muscle, peripheral T, NK subset |
modifies integrins during differentiation, ADP ribosylation of target proteins |
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CD297 |
ART4, dombrock blood group |
38kD |
ADP- ribosyltransferase |
erythroid, monoact |
ADP ribosylation of target proteins |
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CD298 |
Na+/K+-ATPase b3 subunit |
52kD |
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broad |
transport sodium & potassium ions across membrane |
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CD299 |
DC-SIGN-related, LSIGN, DC-SIGN2 |
45kD |
Type II, similar to CD209, ASV |
endothelial subset |
binds ICAM3, HIV-1 gp120, coreceptor with DC-SIGN, HIV infection |
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CD300a |
CMRF35H, IRC1, IRp60 |
60kD |
IgSF, ASV |
NK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML |
unknown |
| CD300c |
CMRF35A, LIR |
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IgSF |
mono, neutrophils, monocytic cell lines, B & T subsets |
unknown |
| CD300e |
CMRF35L |
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IgSF CMRF family |
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unknown |
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CD301 |
MGL, HML |
38kD |
C type lectin SF, ASV |
immature DC |
binds Tn antigen, uptake of glycosylated antigens |
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CD302 |
DCL1, BIMLEC |
19-28kD |
Type I TM C-type lectin receptor |
some myeloid and Hodgkin’s cell lines |
a fusion protein in Hodgkin’s lymphoma with DEC-205 |
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CD303 |
BDCA2, HECL |
38kD |
C-type lectin SF ASV |
plasmacytoid dendritic cells |
inhibit IFN-alpha production |
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CD304 |
BDCA4, neuropilin 1 |
130kD |
semaphorin family |
neurons, CD4+/CD25+ Treg, DC, endothelial and tumor cells |
interacts with VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration |
| CD305 |
LAIR1 |
32-40kD |
IgSF, ASV |
NK, B, T, mono |
inhibitory receptor on NK and T cells |
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CD306 |
LAIR2 |
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IgSF, ASV |
unknown |
soluble, mucosal tolerance |
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CD307 |
IRTA2 |
55-105kD |
IgSF (Fc receptor), ASV |
B subset, B lymphoma |
B cell development, translocation in some lymphomas |
| CD309 |
VEGFR2, KDR |
230kD |
Type III TM tyr kinase |
endothelial, angiogenic precursor cells, hemangioblast |
binds VEGF, regulates adhesion and cell signaling |
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CD312 |
EMR2 |
90kD |
EGFR-7TM ASV |
mono, mac, moDC, granslow |
cell adhesion and migration for phagocytosis |
| CD314 |
NKG2D, KLR |
42kD |
Type II lectin-like receptor |
NK, CD8+ activated, NK1.1+ T, some myeloid cells |
binds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation |
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CD315 |
CD9P1, SMAP6, FPRP, PTGFRN |
135kD |
IgSF |
B subset, monoact |
with CD81 and CD9 |
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CD316 |
EWI2, PGRL, CD81P3, KASP |
63-75kD |
IgSF8 |
B, T cells, low on NK cells |
with CD81 & CD9; involved in cell migration |
| CD317 |
BST2, HM1.24 |
30-36kD |
Type II |
B, T, NK, mono, DC, fibroblast cell line, myeloma |
pre-B cell growth, overexpressed in multiple myeloma |
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CD318 |
CDCP1, SIMA135 |
135kD |
Type I, ASV |
HSC (subset of CD34+), tumors |
cell adhesion with ECM |
| CD319 |
CRACC, SLAMF7 |
66kD |
Ig TM |
T, B and DC subset, NK, upregulated in DC |
regulate T and NK cells |
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CD320 |
8D6A, 8D6 |
30kD |
LDL receptor |
follicular DC, germinal centers |
B proliferation, tumor formation |
| CD321 |
JAM1, F11 receptor |
35kD |
IgSF, Type I, ASV |
platelet receptor, epithelia and endothelial, platelets |
tight junctions |
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CD322 |
JAM2, VE-JAM |
43kD |
IgSF |
HEV, other endoth |
cell adhesion, lymphocyte homing to secondary lymphoid organs |
| CD324 |
E-Cadherin, Uvomorulin |
120kD |
cadherin SF |
non-neural epith |
cell adhesion, homotypic interaction & binds alphaE/ b7 |
| CD325 |
N-Cadherin, NCAD |
140kD |
cadherin SF |
brain, skeletal and cardiac muscle |
cell adhesion, neuronal recognition |
| CD326 |
Ep-CAM, Ly74 |
35-40kD |
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most epith cell membranes |
growth factor receptor? |
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CD327 |
SIGLEC6 |
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IgSF |
placenta, spleen, B . sialic-acid dependent |
adhesion, membrane- bound & secreted forms |
| CD328 |
SIGLEC7, AIRM-1 |
75kD |
IgSF |
resting and activated NK, placenta, liver, spleen, lower in gran & mono |
sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis |
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CD329 |
SIGLEC9 |
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IgSF |
neutrophils and mono |
sialic-acid dependent adhesion molecule |
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CD331 |
FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM |
30kD |
TM tyr kinase |
fibroblasts, epithelial |
binds FGF, high affinity receptor for fibroblast growth factors |
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CD332 |
FGFR2, BEK, KGFR |
115-135kD |
TM RTK family |
fibroblasts, epithelial |
binds FGF, high affinity receptor for fibroblast growth factors |
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CD333 |
FGFR3, ACH, CEK2 |
115kD |
TM RTK family |
fibroblasts, epithelial |
binds FGF, high affinity receptor for fibroblast growth factors |
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CD334 |
FGFR4, JTK2, TKF |
110kD |
TM RTK family |
fibroblasts, epithelial |
binds FGF, high affinity receptor for fibroblast growth factors |
| CD335 |
NKp46, Ly-94 homolog |
46kD |
IgSF |
NK |
activates NK cells upon non-MHC ligand binding |
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CD336 |
NKp44, Ly-95 homolog |
44kD |
IgSF |
NK |
activates NK cells upon non-MHC ligand binding |
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CD337 |
NKp30, Ly117 |
30kD |
IgSF |
NK |
activates NK cells upon non-MHC ligand binding |
| CD338 |
ABCG2, BCRP, Bcrp1, MXR |
73kD |
GPCR 7TM |
stem cell subset (side population) |
multi-drug resistance transporter |
| CD339 |
Jagged-1, JAG1, JAGL1, hJ1 |
135kD |
EGF TM |
stromal cells, epithelial, AML |
binds Notch, hematopoiesis |