RAS induced exosome SASP in fibroblasts (day 7)

Comparison

UniProtIds

Protein Description

Genes

Log2 Ratio

Std. Dev.

PValue

QValue

GO Biological Process

GO Molecular Process

GO Cellular Process

Ratios

Unique Peptides

Elution Groups

Elution Group

SEN / CTL

P05362

Intercellular adhesion molecule 1

ICAM1

5.86

2.42

9.59e-20

2.4e-17

ovarian follicle development,regulation of leukocy...

virus receptor activity,receptor activity,transmem...

immunological synapse,extracellular space,plasma m...

55

18

22

GGSVLVTC[CAM]STSC[CAM]DQPK.2|DGTFPLPIGESVTVTR.2|LL...

SEN / CTL

P29966

Myristoylated alanine-rich C-kinase substrate

MARCKS

4.06

1.83

0.00609

0.0374

regulation of insulin secretion

protein kinase C binding,calmodulin binding,actin ...

centrosome,plasma membrane,focal adhesion,cell cor...

5

20

36

TAAKGEAAAERPGEAAVASSPSK.4|TAAKGEAAAERPGEAAVASSPSK....

SEN / CTL

P22692

Insulin-like growth factor-binding protein 4

IGFBP4

3.5

2.45

0.00121

0.0138

skeletal system development,regulation of cell gro...

receptor binding,insulin-like growth factor I bind...

extracellular region,extracellular space

15

3

5

EDARPVPQGSC[CAM]QSELHR.4|GELDC[CAM]HQLADSFRE.3|GEL...

SEN / CTL

P21589

5'-nucleotidase

NT5E

2.82

2.62

0.0000446

0.000857

purine nucleotide catabolic process,AMP catabolic ...

nucleotide binding,5'-nucleotidase activity,metal ...

cytoplasm,plasma membrane,cell surface,membrane,an...

125

28

42

FPILSANIK.2|TIVYLDGSSQSC[CAM]R.2|EVPAGKYPFIVTSDDGR...

SEN / CTL

P04083

Annexin A1

ANXA1

2.63

2.25

3.83e-9

4.78e-7

DNA strand renaturation,neutrophil homeostasis,ada...

single-stranded DNA binding,single-stranded RNA bi...

cornified envelope,phagocytic cup,extracellular re...

170

38

69

TPAQFDADELR.2|GVDEATIIDILTKR.3|NALLSLAK.2|DLAKDITS...

SEN / CTL

Q15758

Neutral amino acid transporter B(0)

SLC1A5

2.61

3.37

0.00168

0.0171

amino acid transmembrane transport,extracellular a...

virus receptor activity,receptor activity,protein ...

Golgi apparatus,plasma membrane,integral component...

25

16

21

STEPELIQVK.2|SELPLDPLPVPTEEGNPLLK.3|SELPLDPLPVPTEE...

SEN / CTL

P26038

Moesin

MSN

2.37

2.3

0.00288

0.0249

movement of cell or subcellular component,cytoskel...

double-stranded RNA binding,actin binding,receptor...

uropod,extracellular space,nucleus,cytoplasm,cytos...

190

65

122

IGFPWSEIR.2|ERQEAEEAKEALLQASR.4|ERQEAEEAKEALLQASR....

SEN / CTL

P80723

Brain acid soluble protein 1

BASP1

2.34

2.63

5.45e-8

0.00000341

thorax and anterior abdomen determination,gonad de...

transcription corepressor activity,protein binding...

nucleus,cytoplasm,cytoskeleton,plasma membrane,nuc...

60

28

41

AQGPAASAEEPKPVEAPAANSDQTVTVKE.3|AQGPAASAEEPKPVEAPA...

SEN / CTL

Q09666

Neuroblast differentiation-associated protein AHNAK

AHNAK

2.3

2.21

0.00447

0.0307

regulation of RNA splicing,protein oligomerization...

protein binding,S100 protein binding,poly(A) RNA b...

nucleus,cytoplasm,lysosomal membrane,cytosol,plasm...

280

433

666

LPTGQISGPEIK.2|LNVGAPDVTLR.2|ISMPEVDLNLKGPK.3|IKGD...

SEN / CTL

P09972

Fructose-bisphosphate aldolase C

ALDOC

2.06

2.08

0.0000484

0.000865

fructose metabolic process,gluconeogenesis,fructos...

fructose-bisphosphate aldolase activity,protein bi...

mitochondrion,cytosol,cytoskeleton,extracellular e...

30

27

42

VDKGVVPLAGTDGETTTQGLDGLSER.3|VDKGVVPLAGTDGETTTQGLD...

SEN / CTL

P17301

Integrin alpha-2

ITGA2

1.84

2.04

0.00000322

0.000101

response to hypoxia,positive regulation of leukocy...

virus receptor activity,integrin binding,protein b...

nucleus,plasma membrane,focal adhesion,integrin co...

95

27

31

KGILGQHQFLEGPEGIENTR.3|VVFNLNTYK.2|SVAC[CAM]DVGYPA...

SEN / CTL

P04004

Vitronectin

VTN

1.68

1.43

0.00442

0.0307

receptor-mediated endocytosis,immune response,cell...

scavenger receptor activity,integrin binding,prote...

extracellular region,basement membrane,extracellul...

15

22

33

DVWGIEGPIDAAFTR.2|DVWGIEGPIDAAFTR.3|LIRDVWGIEGPIDA...

SEN / CTL

P19013

Keratin, type II cytoskeletal 4

KRT4

1.59

1.49

0.00233

0.0224

cytoskeleton organization,epithelial cell differen...

structural molecule activity,protein binding

nucleus,intermediate filament,cell surface,keratin...

25

21

22

LALDIEIATYR.2|FASFIDKVQFLEQQNK.3|NLDLDSIIAEVR.2|II...

SEN / CTL

P07355

Annexin A2

ANXA2

1.54

2.4

1.43e-7

0.00000714

angiogenesis,membrane raft assembly,positive regul...

protease binding,calcium ion binding,protein bindi...

ruffle,basement membrane,extracellular space,nucle...

285

49

99

DLYDAGVK.2|AEDGSVIDYELIDQDAR.3|AEDGSVIDYELIDQDAR.2...

SEN / CTL

Q12931

Heat shock protein 75 kDa, mitochondrial

TRAP1

1.42

0.87

0.00114

0.0135

response to stress,translational attenuation,chape...

tumor necrosis factor receptor binding,protein bin...

nucleoplasm,mitochondrion,mitochondrial inner memb...

10

53

85

GVVDSEDIPLNLSR.2|GVVDSEDIPLNLSR.3|LNELLVK.2|HLAEHS...

SEN / CTL

P06702

Protein S100-A9

S100A9

1.32

0.97

0.00314

0.0259

cytokine production,leukocyte migration involved i...

signal transducer activity,calcium ion binding,pro...

extracellular region,extracellular space,nucleus,c...

10

18

44

LGHPDTLNQGEFK.3|LGHPDTLNQGEFK.2|NIETIINTFHQYSVK.3|...

SEN / CTL

P04406

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

1.09

2.29

0.0000371

0.000857

microtubule cytoskeleton organization,gluconeogene...

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (p...

nucleus,cytoplasm,lipid particle,cytosol,plasma me...

140

51

166

VPTANVSVVDLTC[CAM]R.2|VPTANVSVVDLTC[CAM]R.3|GALQNI...

SEN / CTL

Q86YZ3

Hornerin

HRNR

1.06

1

0.00613

0.0374

keratinization,cell envelope organization,establis...

calcium ion binding

cornified envelope,nucleus,cytoplasm,cell envelope...

15

34

56

HGSGSGQSSSYSPYGSGSGWSSSR.3|HGSGSGQSSSYGPYGSGSGWSSS...

SEN / CTL

P69905

Hemoglobin subunit alpha

HBA1

1.06

1.55

0.00724

0.0431

receptor-mediated endocytosis,positive regulation ...

oxygen transporter activity,iron ion binding,prote...

extracellular region,cytosol,hemoglobin complex,me...

35

23

78

MFLSFPTTK.2|M[Oxi]FLSFPTTK.2|LRVDPVNFK.2|VGAHAGEYG...

SEN / CTL

Q562R1

Beta-actin-like protein 2

ACTBL2

0.71

2.68

0.000528

0.00826

biological_process

molecular_function,ATP binding

extracellular space,cytoplasm,cytoskeleton,extrace...

45

9

17

VAPDEHPILLTEAPLNPK.3|VAPDEHPILLTEAPLNPK.4|KDLYANTV...

SEN / CTL

P60709

P63261

Actin, cytoplasmic 1;Actin, cytoplasmic 2

ACTB

ACTG1

0.32

2.14

0.0000184

0.000512

retina homeostasis,movement of cell or subcellular...

structural constituent of cytoskeleton,protein bin...

nuclear chromatin,extracellular space,nucleoplasm,...

160

11

55

GYSFTTTAER.2|VAPEEHPVLLTEAPLNPK.3|VAPEEHPVLLTEAPLN...

SEN / CTL

P13929

Beta-enolase

ENO3

0.18

3.05

0.000638

0.00926

gluconeogenesis,aging,response to drug,skeletal mu...

magnesium ion binding,phosphopyruvate hydratase ac...

phosphopyruvate hydratase complex,extracellular sp...

25

16

23

VNQIGSVTESIQAC[CAM]K.2|VNQIGSVTESIQAC[CAM]K.3|YGKD...

SEN / CTL

P68032

Actin, alpha cardiac muscle 1

ACTC1

-0.2

2.72

0.00512

0.0333

apoptotic process,positive regulation of gene expr...

ATP binding,ATPase activity,myosin binding

extracellular space,cytoplasm,cytosol,actin filame...

225

28

98

SYELPDGQVITIGNER.2|SYELPDGQVITIGNER.3|AVFPSIVGRPR....

SEN / CTL

P06733

Alpha-enolase

ENO1

-0.49

2.16

0.0000415

0.000857

gluconeogenesis,transcription, DNA-templated,respo...

magnesium ion binding,DNA binding,phosphopyruvate ...

phosphopyruvate hydratase complex,extracellular sp...

120

54

117

VNQIGSVTESLQAC[CAM]K.2|VNQIGSVTESLQAC[CAM]K.3|AAVP...

SEN / CTL

P22392

Nucleoside diphosphate kinase B

NME2

-0.68

1

0.00455

0.0307

negative regulation of myeloid leukocyte different...

DNA binding,transcription factor activity, sequenc...

ruffle,nucleus,cytoplasm,cytosol,intermediate fila...

30

19

36

GDFC[CAM]IQVGR.2|SC[CAM]AHDWVYE.2|TFIAIKPDGVQR.3|T...

SEN / CTL

P56199

Integrin alpha-1

ITGA1

-0.83

1.51

0.00271

0.0242

activation of MAPK activity,muscle contraction,cel...

receptor binding,protein binding,collagen binding,...

acrosomal vesicle,plasma membrane,focal adhesion,i...

30

13

15

VIQDC[CAM]EDENIQR.2|ASQIIIPR.2|FGTAIAAVK.2|FSIAILG...

SEN / CTL

Q8WUM4

Programmed cell death 6-interacting protein

PDCD6IP

-0.87

1.6

0.00000135

0.0000482

cell separation after cytokinesis,apoptotic proces...

protein binding,proteinase activated receptor bind...

immunological synapse,cytoplasm,microtubule organi...

130

63

96

STPVNVPISQK.2|EVFPVLAAK.2|FYNELTEILVR.2|LANQAADYFG...

SEN / CTL

P16401

Histone H1.5

HIST1H1B

-0.87

1.2

0.00404

0.0306

negative regulation of transcription from RNA poly...

chromatin DNA binding,histone deacetylase binding,...

nucleosome,nuclear chromatin,nuclear heterochromat...

30

13

17

ALAAGGYDVEK.2|ALAAGGYDVEKNNSR.3|KATGPPVSELITK.3|KA...

SEN / CTL

P60866

40S ribosomal protein S20

RPS20

-1.08

1.13

0.000667

0.00926

nuclear-transcribed mRNA catabolic process, nonsen...

structural constituent of ribosome,poly(A) RNA bin...

nucleoplasm,cytoplasm,cytosol,membrane,cytosolic s...

15

5

10

LIDLHSPSEIVK.3|LIDLHSPSEIVK.2|DTGKTPVEPEVAIHR.4|DT...

SEN / CTL

P14618

Pyruvate kinase PKM

PKM

-1.08

2.43

0.000759

0.00999

programmed cell death,canonical glycolysis,cell-ce...

magnesium ion binding,pyruvate kinase activity,pro...

nucleus,cytoplasm,mitochondrion,cytosol,plasma mem...

225

71

161

GDLGIEIPAEK.2|KGVNLPGAAVDLPAVSEKDIQDLK.4|KGVNLPGAA...

SEN / CTL

P04217

Alpha-1B-glycoprotein

A1BG

-1.13

0.42

0.00442

0.0307

platelet degranulation,biological_process

molecular_function

extracellular region,extracellular space,platelet ...

5

21

40

GVTFLLR.2|RGEKELLVPR.3|LELHVDGPPPR.3|LELHVDGPPPRPQ...

SEN / CTL

P12110

Collagen alpha-2(VI) chain

COL6A2

-1.22

2.42

0.000414

0.00691

cell adhesion,response to glucose,extracellular ma...

extracellular region,proteinaceous extracellular m...

155

42

57

NFVINVVNR.2|LFAVAPNQNLK.2|VFAVVITDGR.2|DIASTPHELYR...

SEN / CTL

Q9Y4K0

Lysyl oxidase homolog 2

LOXL2

-1.31

2.08

0.00327

0.0259

response to hypoxia,epithelial to mesenchymal tran...

chromatin binding,transcription corepressor activi...

basement membrane,extracellular space,nucleus,nucl...

35

16

19

VVC[CAM]GMFGFPGER.2|FNAESQGC[CAM]NHEEDAGVR.3|LGQGI...

SEN / CTL

P62249

40S ribosomal protein S16

RPS16

-1.44

1.87

0.00519

0.0333

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleoplasm,cytosol,focal adhesion,small ribosomal...

30

14

19

TLLVADPR.2|LLEPVLLLGK.2|EIKDILIQYDR.3|EIKDILIQYDR....

SEN / CTL

P10412

P16402

P16403

Histone H1.4;Histone H1.3;Histone H1.2

HIST1H1E

HIST1H1D

HIST1H1C

-1.62

1.75

0.0000436

0.000857

negative regulation of transcription from RNA poly...

protein binding,chromatin DNA binding,poly(A) RNA ...

nucleosome,nucleus,nuclear heterochromatin,extrace...

45

7

12

ALAAAGYDVEK.2|ALAAAGYDVEKNNSR.3|ALAAAGYDVEKNNSR.2|...

SEN / CTL

P12109

Collagen alpha-1(VI) chain

COL6A1

-1.71

1.78

5.6e-7

0.0000233

osteoblast differentiation,cell adhesion,extracell...

platelet-derived growth factor binding

extracellular region,collagen type VI trimer,lysos...

195

49

69

IALVITDGR.2|VPSYQALLR.2|VFSVAITPDHLEPR.3|VFSVAITPD...

SEN / CTL

P62805

Histone H4

HIST1H4A

-1.84

2.74

0.000849

0.0106

chromatin silencing at rDNA,double-strand break re...

DNA binding,protein binding,protein domain specifi...

nuclear chromosome,nuclear chromosome, telomeric r...

80

24

44

DNIQGITKPAIR.3|DNIQGITKPAIR.2|ISGLIYEETR.2|VFLENVI...

SEN / CTL

P13646

Keratin, type I cytoskeletal 13

KRT13

-2.33

2.53

0.00332

0.0259

cytoskeleton organization,response to radiation,to...

structural molecule activity

nucleus,keratin filament,intermediate filament cyt...

20

11

16

VILEIDNAR.2|ILTATIENNR.2|ITMQNLNDR.2|ITM[Oxi]QNLND...

SEN / CTL

P12111

Collagen alpha-3(VI) chain

COL6A3

-2.78

2.24

1.61e-8

0.00000134

cell adhesion,muscle organ development,negative re...

serine-type endopeptidase inhibitor activity

extracellular region,proteinaceous extracellular m...

855

165

233

ELPNIEER.2|EVQVFEITENSAK.2|YIAYLVR.2|LLVLITGGK.2|A...

SEN / CTL

O60814

P57053

P58876

P62807

Q5QNW6

Q93079

Q99877

Q99879

Q99880

Histone H2B type 1-K;Histone H2B type F-S;Histone H2B type 1-D;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-F;Histone H2B type 1-H;Histone H2B type 1-N;Histone H2B type 1-M;Histone H2B type 1-L

HIST1H2BK

H2BFS

HIST1H2BD

HIST1H2BC

HIST2H2BF

HIST1H2BH

HIST1H2BN

HIST1H2BM

HIST1H2BL

-4.26

3.12

0.00268

0.0242

innate immune response in mucosa,nucleosome assemb...

molecular_function,DNA binding,protein heterodimer...

nuclear nucleosome,extracellular space,nucleus,nuc...

15

2

3

ESYSVYVYK.2|KESYSVYVYK.3|KESYSVYVYK.2

SEN / CTL

Q14114

Low-density lipoprotein receptor-related protein 8

LRP8

-4.28

1.16

0.00162

0.0171

negative regulation of transcription from RNA poly...

transmembrane signaling receptor activity,low-dens...

extracellular region,microtubule associated comple...

5

1

1

AIAVDPLR.2

SEN / CTL

P06899

P23527

P33778

Q16778

Q8N257

Histone H2B type 1-J;Histone H2B type 1-O;Histone H2B type 1-B;Histone H2B type 2-E;Histone H2B type 3-B

HIST1H2BJ

HIST1H2BO

HIST1H2BB

HIST2H2BE

HIST3H2BB

-5.52

3.23

0.00171

0.0171

innate immune response in mucosa,nucleosome assemb...

DNA binding,protein heterodimerization activity;DN...

nucleosome,nuclear nucleosome,extracellular space,...

40

4

12

LLLPGELAK.2|ESYSIYVYK.2|AMGIMNSFVNDIFER.2|AMGIMNSF...