RAS induced exosome SASP in fibroblasts (day 7)

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Comparison


UniProtIds


Protein Description


Genes


Log2 Ratio


Std. Dev.


PValue


QValue


GO Biological Process


GO Molecular Process


GO Cellular Process


Ratios


Unique Peptides


Elution Groups


Elution Group


SEN / CTL


P05362


Intercellular adhesion molecule 1


ICAM1


5.86


2.42


9.59e-20


2.4e-17


ovarian follicle development,regulation of leukocy…


virus receptor activity,receptor activity,transmem…


immunological synapse,extracellular space,plasma m…


55


18


22


GGSVLVTC[CAM]STSC[CAM]DQPK.2|DGTFPLPIGESVTVTR.2|LL…


SEN / CTL


P29966


Myristoylated alanine-rich C-kinase substrate


MARCKS


4.06


1.83


0.00609


0.0374


regulation of insulin secretion


protein kinase C binding,calmodulin binding,actin …


centrosome,plasma membrane,focal adhesion,cell cor…


5


20


36


TAAKGEAAAERPGEAAVASSPSK.4|TAAKGEAAAERPGEAAVASSPSK….


SEN / CTL


P22692


Insulin-like growth factor-binding protein 4


IGFBP4


3.5


2.45


0.00121


0.0138


skeletal system development,regulation of cell gro…


receptor binding,insulin-like growth factor I bind…


extracellular region,extracellular space


15


3


5


EDARPVPQGSC[CAM]QSELHR.4|GELDC[CAM]HQLADSFRE.3|GEL…


SEN / CTL


P21589


5′-nucleotidase


NT5E


2.82


2.62


0.0000446


0.000857


purine nucleotide catabolic process,AMP catabolic …


nucleotide binding,5′-nucleotidase activity,metal …


cytoplasm,plasma membrane,cell surface,membrane,an…


125


28


42


FPILSANIK.2|TIVYLDGSSQSC[CAM]R.2|EVPAGKYPFIVTSDDGR…


SEN / CTL


P04083


Annexin A1


ANXA1


2.63


2.25


3.83e-9


4.78e-7


DNA strand renaturation,neutrophil homeostasis,ada…


single-stranded DNA binding,single-stranded RNA bi…


cornified envelope,phagocytic cup,extracellular re…


170


38


69


TPAQFDADELR.2|GVDEATIIDILTKR.3|NALLSLAK.2|DLAKDITS…


SEN / CTL


Q15758


Neutral amino acid transporter B(0)


SLC1A5


2.61


3.37


0.00168


0.0171


amino acid transmembrane transport,extracellular a…


virus receptor activity,receptor activity,protein …


Golgi apparatus,plasma membrane,integral component…


25


16


21


STEPELIQVK.2|SELPLDPLPVPTEEGNPLLK.3|SELPLDPLPVPTEE…


SEN / CTL


P26038


Moesin


MSN


2.37


2.3


0.00288


0.0249


movement of cell or subcellular component,cytoskel…


double-stranded RNA binding,actin binding,receptor…


uropod,extracellular space,nucleus,cytoplasm,cytos…


190


65


122


IGFPWSEIR.2|ERQEAEEAKEALLQASR.4|ERQEAEEAKEALLQASR….


SEN / CTL


P80723


Brain acid soluble protein 1


BASP1


2.34


2.63


5.45e-8


0.00000341


thorax and anterior abdomen determination,gonad de…


transcription corepressor activity,protein binding…


nucleus,cytoplasm,cytoskeleton,plasma membrane,nuc…


60


28


41


AQGPAASAEEPKPVEAPAANSDQTVTVKE.3|AQGPAASAEEPKPVEAPA…


SEN / CTL


Q09666


Neuroblast differentiation-associated protein AHNAK


AHNAK


2.3


2.21


0.00447


0.0307


regulation of RNA splicing,protein oligomerization…


protein binding,S100 protein binding,poly(A) RNA b…


nucleus,cytoplasm,lysosomal membrane,cytosol,plasm…


280


433


666


LPTGQISGPEIK.2|LNVGAPDVTLR.2|ISMPEVDLNLKGPK.3|IKGD…


SEN / CTL


P09972


Fructose-bisphosphate aldolase C


ALDOC


2.06


2.08


0.0000484


0.000865


fructose metabolic process,gluconeogenesis,fructos…


fructose-bisphosphate aldolase activity,protein bi…


mitochondrion,cytosol,cytoskeleton,extracellular e…


30


27


42


VDKGVVPLAGTDGETTTQGLDGLSER.3|VDKGVVPLAGTDGETTTQGLD…


SEN / CTL


P17301


Integrin alpha-2


ITGA2


1.84


2.04


0.00000322


0.000101


response to hypoxia,positive regulation of leukocy…


virus receptor activity,integrin binding,protein b…


nucleus,plasma membrane,focal adhesion,integrin co…


95


27


31


KGILGQHQFLEGPEGIENTR.3|VVFNLNTYK.2|SVAC[CAM]DVGYPA…


SEN / CTL


P04004


Vitronectin


VTN


1.68


1.43


0.00442


0.0307


receptor-mediated endocytosis,immune response,cell…


scavenger receptor activity,integrin binding,prote…


extracellular region,basement membrane,extracellul…


15


22


33


DVWGIEGPIDAAFTR.2|DVWGIEGPIDAAFTR.3|LIRDVWGIEGPIDA…


SEN / CTL


P19013


Keratin, type II cytoskeletal 4


KRT4


1.59


1.49


0.00233


0.0224


cytoskeleton organization,epithelial cell differen…


structural molecule activity,protein binding


nucleus,intermediate filament,cell surface,keratin…


25


21


22


LALDIEIATYR.2|FASFIDKVQFLEQQNK.3|NLDLDSIIAEVR.2|II…


SEN / CTL


P07355


Annexin A2


ANXA2


1.54


2.4


1.43e-7


0.00000714


angiogenesis,membrane raft assembly,positive regul…


protease binding,calcium ion binding,protein bindi…


ruffle,basement membrane,extracellular space,nucle…


285


49


99


DLYDAGVK.2|AEDGSVIDYELIDQDAR.3|AEDGSVIDYELIDQDAR.2…


SEN / CTL


Q12931


Heat shock protein 75 kDa, mitochondrial


TRAP1


1.42


0.87


0.00114


0.0135


response to stress,translational attenuation,chape…


tumor necrosis factor receptor binding,protein bin…


nucleoplasm,mitochondrion,mitochondrial inner memb…


10


53


85


GVVDSEDIPLNLSR.2|GVVDSEDIPLNLSR.3|LNELLVK.2|HLAEHS…


SEN / CTL


P06702


Protein S100-A9


S100A9


1.32


0.97


0.00314


0.0259


cytokine production,leukocyte migration involved i…


signal transducer activity,calcium ion binding,pro…


extracellular region,extracellular space,nucleus,c…


10


18


44


LGHPDTLNQGEFK.3|LGHPDTLNQGEFK.2|NIETIINTFHQYSVK.3|…


SEN / CTL


P04406


Glyceraldehyde-3-phosphate dehydrogenase


GAPDH


1.09


2.29


0.0000371


0.000857


microtubule cytoskeleton organization,gluconeogene…


glyceraldehyde-3-phosphate dehydrogenase (NAD+) (p…


nucleus,cytoplasm,lipid particle,cytosol,plasma me…


140


51


166


VPTANVSVVDLTC[CAM]R.2|VPTANVSVVDLTC[CAM]R.3|GALQNI…


SEN / CTL


Q86YZ3


Hornerin


HRNR


1.06


1


0.00613


0.0374


keratinization,cell envelope organization,establis…


calcium ion binding


cornified envelope,nucleus,cytoplasm,cell envelope…


15


34


56


HGSGSGQSSSYSPYGSGSGWSSSR.3|HGSGSGQSSSYGPYGSGSGWSSS…


SEN / CTL


P69905


Hemoglobin subunit alpha


HBA1


1.06


1.55


0.00724


0.0431


receptor-mediated endocytosis,positive regulation …


oxygen transporter activity,iron ion binding,prote…


extracellular region,cytosol,hemoglobin complex,me…


35


23


78


MFLSFPTTK.2|M[Oxi]FLSFPTTK.2|LRVDPVNFK.2|VGAHAGEYG…


SEN / CTL


Q562R1


Beta-actin-like protein 2


ACTBL2


0.71


2.68


0.000528


0.00826


biological_process


molecular_function,ATP binding


extracellular space,cytoplasm,cytoskeleton,extrace…


45


9


17


VAPDEHPILLTEAPLNPK.3|VAPDEHPILLTEAPLNPK.4|KDLYANTV…


SEN / CTL


P60709


P63261


Actin, cytoplasmic 1;Actin, cytoplasmic 2


ACTB


ACTG1


0.32


2.14


0.0000184


0.000512


retina homeostasis,movement of cell or subcellular…


structural constituent of cytoskeleton,protein bin…


nuclear chromatin,extracellular space,nucleoplasm,…


160


11


55


GYSFTTTAER.2|VAPEEHPVLLTEAPLNPK.3|VAPEEHPVLLTEAPLN…


SEN / CTL


P13929


Beta-enolase


ENO3


0.18


3.05


0.000638


0.00926


gluconeogenesis,aging,response to drug,skeletal mu…


magnesium ion binding,phosphopyruvate hydratase ac…


phosphopyruvate hydratase complex,extracellular sp…


25


16


23


VNQIGSVTESIQAC[CAM]K.2|VNQIGSVTESIQAC[CAM]K.3|YGKD…


SEN / CTL


P68032


Actin, alpha cardiac muscle 1


ACTC1


-0.2


2.72


0.00512


0.0333


apoptotic process,positive regulation of gene expr…


ATP binding,ATPase activity,myosin binding


extracellular space,cytoplasm,cytosol,actin filame…


225


28


98


SYELPDGQVITIGNER.2|SYELPDGQVITIGNER.3|AVFPSIVGRPR….


SEN / CTL


P06733


Alpha-enolase


ENO1


-0.49


2.16


0.0000415


0.000857


gluconeogenesis,transcription, DNA-templated,respo…


magnesium ion binding,DNA binding,phosphopyruvate …


phosphopyruvate hydratase complex,extracellular sp…


120


54


117


VNQIGSVTESLQAC[CAM]K.2|VNQIGSVTESLQAC[CAM]K.3|AAVP…


SEN / CTL


P22392


Nucleoside diphosphate kinase B


NME2


-0.68


1


0.00455


0.0307


negative regulation of myeloid leukocyte different…


DNA binding,transcription factor activity, sequenc…


ruffle,nucleus,cytoplasm,cytosol,intermediate fila…


30


19


36


GDFC[CAM]IQVGR.2|SC[CAM]AHDWVYE.2|TFIAIKPDGVQR.3|T…


SEN / CTL


P56199


Integrin alpha-1


ITGA1


-0.83


1.51


0.00271


0.0242


activation of MAPK activity,muscle contraction,cel…


receptor binding,protein binding,collagen binding,…


acrosomal vesicle,plasma membrane,focal adhesion,i…


30


13


15


VIQDC[CAM]EDENIQR.2|ASQIIIPR.2|FGTAIAAVK.2|FSIAILG…


SEN / CTL


Q8WUM4


Programmed cell death 6-interacting protein


PDCD6IP


-0.87


1.6


0.00000135


0.0000482


cell separation after cytokinesis,apoptotic proces…


protein binding,proteinase activated receptor bind…


immunological synapse,cytoplasm,microtubule organi…


130


63


96


STPVNVPISQK.2|EVFPVLAAK.2|FYNELTEILVR.2|LANQAADYFG…


SEN / CTL


P16401


Histone H1.5


HIST1H1B


-0.87


1.2


0.00404


0.0306


negative regulation of transcription from RNA poly…


chromatin DNA binding,histone deacetylase binding,…


nucleosome,nuclear chromatin,nuclear heterochromat…


30


13


17


ALAAGGYDVEK.2|ALAAGGYDVEKNNSR.3|KATGPPVSELITK.3|KA…


SEN / CTL


P60866


40S ribosomal protein S20


RPS20


-1.08


1.13


0.000667


0.00926


nuclear-transcribed mRNA catabolic process, nonsen…


structural constituent of ribosome,poly(A) RNA bin…


nucleoplasm,cytoplasm,cytosol,membrane,cytosolic s…


15


5


10


LIDLHSPSEIVK.3|LIDLHSPSEIVK.2|DTGKTPVEPEVAIHR.4|DT…


SEN / CTL


P14618


Pyruvate kinase PKM


PKM


-1.08


2.43


0.000759


0.00999


programmed cell death,canonical glycolysis,cell-ce…


magnesium ion binding,pyruvate kinase activity,pro…


nucleus,cytoplasm,mitochondrion,cytosol,plasma mem…


225


71


161


GDLGIEIPAEK.2|KGVNLPGAAVDLPAVSEKDIQDLK.4|KGVNLPGAA…


SEN / CTL


P04217


Alpha-1B-glycoprotein


A1BG


-1.13


0.42


0.00442


0.0307


platelet degranulation,biological_process


molecular_function


extracellular region,extracellular space,platelet …


5


21


40


GVTFLLR.2|RGEKELLVPR.3|LELHVDGPPPR.3|LELHVDGPPPRPQ…


SEN / CTL


P12110


Collagen alpha-2(VI) chain


COL6A2


-1.22


2.42


0.000414


0.00691


cell adhesion,response to glucose,extracellular ma…


extracellular region,proteinaceous extracellular m…


155


42


57


NFVINVVNR.2|LFAVAPNQNLK.2|VFAVVITDGR.2|DIASTPHELYR…


SEN / CTL


Q9Y4K0


Lysyl oxidase homolog 2


LOXL2


-1.31


2.08


0.00327


0.0259


response to hypoxia,epithelial to mesenchymal tran…


chromatin binding,transcription corepressor activi…


basement membrane,extracellular space,nucleus,nucl…


35


16


19


VVC[CAM]GMFGFPGER.2|FNAESQGC[CAM]NHEEDAGVR.3|LGQGI…


SEN / CTL


P62249


40S ribosomal protein S16


RPS16


-1.44


1.87


0.00519


0.0333


nuclear-transcribed mRNA catabolic process, nonsen…


RNA binding,structural constituent of ribosome,pol…


nucleoplasm,cytosol,focal adhesion,small ribosomal…


30


14


19


TLLVADPR.2|LLEPVLLLGK.2|EIKDILIQYDR.3|EIKDILIQYDR….


SEN / CTL


P10412


P16402


P16403


Histone H1.4;Histone H1.3;Histone H1.2


HIST1H1E


HIST1H1D


HIST1H1C


-1.62


1.75


0.0000436


0.000857


negative regulation of transcription from RNA poly…


protein binding,chromatin DNA binding,poly(A) RNA …


nucleosome,nucleus,nuclear heterochromatin,extrace…


45


7


12


ALAAAGYDVEK.2|ALAAAGYDVEKNNSR.3|ALAAAGYDVEKNNSR.2|…


SEN / CTL


P12109


Collagen alpha-1(VI) chain


COL6A1


-1.71


1.78


5.6e-7


0.0000233


osteoblast differentiation,cell adhesion,extracell…


platelet-derived growth factor binding


extracellular region,collagen type VI trimer,lysos…


195


49


69


IALVITDGR.2|VPSYQALLR.2|VFSVAITPDHLEPR.3|VFSVAITPD…


SEN / CTL


P62805


Histone H4


HIST1H4A


-1.84


2.74


0.000849


0.0106


chromatin silencing at rDNA,double-strand break re…


DNA binding,protein binding,protein domain specifi…


nuclear chromosome,nuclear chromosome, telomeric r…


80


24


44


DNIQGITKPAIR.3|DNIQGITKPAIR.2|ISGLIYEETR.2|VFLENVI…


SEN / CTL


P13646


Keratin, type I cytoskeletal 13


KRT13


-2.33


2.53


0.00332


0.0259


cytoskeleton organization,response to radiation,to…


structural molecule activity


nucleus,keratin filament,intermediate filament cyt…


20


11


16


VILEIDNAR.2|ILTATIENNR.2|ITMQNLNDR.2|ITM[Oxi]QNLND…


SEN / CTL


P12111


Collagen alpha-3(VI) chain


COL6A3


-2.78


2.24


1.61e-8


0.00000134


cell adhesion,muscle organ development,negative re…


serine-type endopeptidase inhibitor activity


extracellular region,proteinaceous extracellular m…


855


165


233


ELPNIEER.2|EVQVFEITENSAK.2|YIAYLVR.2|LLVLITGGK.2|A…


SEN / CTL


O60814


P57053


P58876


P62807


Q5QNW6


Q93079


Q99877


Q99879


Q99880


Histone H2B type 1-K;Histone H2B type F-S;Histone H2B type 1-D;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-F;Histone H2B type 1-H;Histone H2B type 1-N;Histone H2B type 1-M;Histone H2B type 1-L


HIST1H2BK


H2BFS


HIST1H2BD


HIST1H2BC


HIST2H2BF


HIST1H2BH


HIST1H2BN


HIST1H2BM


HIST1H2BL


-4.26


3.12


0.00268


0.0242


innate immune response in mucosa,nucleosome assemb…


molecular_function,DNA binding,protein heterodimer…


nuclear nucleosome,extracellular space,nucleus,nuc…


15


2


3


ESYSVYVYK.2|KESYSVYVYK.3|KESYSVYVYK.2


SEN / CTL


Q14114


Low-density lipoprotein receptor-related protein 8


LRP8


-4.28


1.16


0.00162


0.0171


negative regulation of transcription from RNA poly…


transmembrane signaling receptor activity,low-dens…


extracellular region,microtubule associated comple…


5


1


1


AIAVDPLR.2


SEN / CTL


P06899


P23527


P33778


Q16778


Q8N257


Histone H2B type 1-J;Histone H2B type 1-O;Histone H2B type 1-B;Histone H2B type 2-E;Histone H2B type 3-B


HIST1H2BJ


HIST1H2BO


HIST1H2BB


HIST2H2BE


HIST3H2BB


-5.52


3.23


0.00171


0.0171


innate immune response in mucosa,nucleosome assemb…


DNA binding,protein heterodimerization activity;DN…


nucleosome,nuclear nucleosome,extracellular space,…


40


4


12


LLLPGELAK.2|ESYSIYVYK.2|AMGIMNSFVNDIFER.2|AMGIMNSF…


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