Pro-longevity genes in Saccharomyces Cerevisiae

Name

Symbol

Entrez ID

Max average lifespan change

Acetyl coa Synthetase

ACS2

850846

70%  Downregulated

Anaphase promoting complex subunit 9

APC9

850792

Downregulated

Anaphase promoting complex subunit CDC26

CDC26

850597

Downregulated

Aspartate AminoTransferase

AAT1

853755

25%  Upregulated

Aspartate AminoTransferase

AAT2

850714

15%  Upregulated

ATP synthase F1 subunit gamma

ATP2

853585

50%  Downregulated

Baculoviral IAP Repeat-containing protein

BIR1

853551

Upregulated

Biosynthesis of Nicotinic Acid

BNA6

850608

Downregulated

Brain Modulosignalin Homologue

BMH2

851676

Upregulated

Ca(2+)-dependent cysteine protease MCA1

MCA1

854372

56%  Upregulated

Cell division cycle

CDC13

851306

Downregulated

Chromosome Transmission Fidelity

CTF4

856254

Downregulated

Copper TRansport

CTR1

856241

Upregulated and Downregulated

Cu, Zn superoxide dismutase

SOD1

853568

Upregulated and Downregulated

Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes

LAT1

855653

20%  Upregulated

Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent

DNA2

856569

Downregulated

Glycerol UTilization

GUT2

854651

25%  Upregulated

Hap4p

HAP4

853751

Upregulated and Downregulated

Hcm1p

HCM1

850429

30%  Upregulated

Hst2p

HST2

856092

Upregulated

hypothetical protein

YKL069W

853794

Downregulated

Inositol phosphoSphingolipid phospholipase C

ISC1

856739

Downregulated

Lag2p

LAG2

854133

36%  Upregulated

Malate DeHydrogenase

MDH1

853777

25%  Upregulated

Malate DeHydrogenase

MDH2

853994

15%  Upregulated

Manganese-containing superoxide dismutase

SOD2

856399

Upregulated and Downregulated

Mpt5p

MPT5

852697

Upregulated and Downregulated

Mxr1p

MXR1

856765

Upregulated and Downregulated

NADH-ubiquinone reductase (H(+)-translocating) NDE2

NDE2

851474

25%  Upregulated

Ndt80p

NDT80

856524

Upregulated

Nicotinatephosphoribosyltranfserase

NPT1

854384

Upregulated and Downregulated

Nuclear Mediator of Apoptosis

NMA111

855600

Upregulated

oxysterol-binding protein OSH6

OSH6

853872

23%  Upregulated

PETite colonies

PET9

852250

30%  Downregulated

Phb1p

PHB1

853033

20%  Downregulated

Phb2p

PHB2

853146

30%  Downregulated

phosphate transporter PHO84

PHO84

854916

14%  Upregulated

potential anaphase-promoting complex processivity factor Apc10

APC10

3640787

Upregulated and Downregulated

Processing of Gas1p and ALP

PGA3

854914

30%  Upregulated

Pyrazinamidase and NiCotinamidase

PNC1

852846

Upregulated and Downregulated

Rad27p

RAD27

853747

50%  Downregulated

RAP1-Interacting Factor

RIF1

852578

30%  Downregulated

Sgs1p

SGS1

855228

30%  Downregulated

Srs2p

SRS2

853353

30%  Downregulated

telomerase_RNA

TLC1

9164870

Upregulated and Downregulated

thioredoxin peroxidase TSA1

TSA1

854980

Upregulated

Transporter of POlyamines

TPO1

850631

Upregulated and Downregulated

Ump1p

UMP1

852471

Upregulated and Downregulated

Yeast Frataxin Homolog

YFH1

851437

50%  Downregulated

Yeast Oligomycin Resistance

YOR1

853198

Upregulated and Downregulated

Zillion Different Screens

ZDS2

854931

20%  Downregulated

Reference: HAGR