Pro-longevity genes in Saccharomyces Cerevisiae

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Name


Symbol


Entrez ID


Max average lifespan change


Acetyl coa Synthetase


ACS2


850846


70%  Downregulated


Anaphase promoting complex subunit 9


APC9


850792


Downregulated


Anaphase promoting complex subunit CDC26


CDC26


850597


Downregulated


Aspartate AminoTransferase


AAT1


853755


25%  Upregulated


Aspartate AminoTransferase


AAT2


850714


15%  Upregulated


ATP synthase F1 subunit gamma


ATP2


853585


50%  Downregulated


Baculoviral IAP Repeat-containing protein


BIR1


853551


Upregulated


Biosynthesis of Nicotinic Acid


BNA6


850608


Downregulated


Brain Modulosignalin Homologue


BMH2


851676


Upregulated


Ca(2+)-dependent cysteine protease MCA1


MCA1


854372


56%  Upregulated


Cell division cycle


CDC13


851306


Downregulated


Chromosome Transmission Fidelity


CTF4


856254


Downregulated


Copper TRansport


CTR1


856241


Upregulated and Downregulated


Cu, Zn superoxide dismutase


SOD1


853568


Upregulated and Downregulated


Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes


LAT1


855653


20%  Upregulated


Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent


DNA2


856569


Downregulated


Glycerol UTilization


GUT2


854651


25%  Upregulated


Hap4p


HAP4


853751


Upregulated and Downregulated


Hcm1p


HCM1


850429


30%  Upregulated


Hst2p


HST2


856092


Upregulated


hypothetical protein


YKL069W


853794


Downregulated


Inositol phosphoSphingolipid phospholipase C


ISC1


856739


Downregulated


Lag2p


LAG2


854133


36%  Upregulated


Malate DeHydrogenase


MDH1


853777


25%  Upregulated


Malate DeHydrogenase


MDH2


853994


15%  Upregulated


Manganese-containing superoxide dismutase


SOD2


856399


Upregulated and Downregulated


Mpt5p


MPT5


852697


Upregulated and Downregulated


Mxr1p


MXR1


856765


Upregulated and Downregulated


NADH-ubiquinone reductase (H(+)-translocating) NDE2


NDE2


851474


25%  Upregulated


Ndt80p


NDT80


856524


Upregulated


Nicotinatephosphoribosyltranfserase


NPT1


854384


Upregulated and Downregulated


Nuclear Mediator of Apoptosis


NMA111


855600


Upregulated


oxysterol-binding protein OSH6


OSH6


853872


23%  Upregulated


PETite colonies


PET9


852250


30%  Downregulated


Phb1p


PHB1


853033


20%  Downregulated


Phb2p


PHB2


853146


30%  Downregulated


phosphate transporter PHO84


PHO84


854916


14%  Upregulated


potential anaphase-promoting complex processivity factor Apc10


APC10


3640787


Upregulated and Downregulated


Processing of Gas1p and ALP


PGA3


854914


30%  Upregulated


Pyrazinamidase and NiCotinamidase


PNC1


852846


Upregulated and Downregulated


Rad27p


RAD27


853747


50%  Downregulated


RAP1-Interacting Factor


RIF1


852578


30%  Downregulated


Sgs1p


SGS1


855228


30%  Downregulated


Srs2p


SRS2


853353


30%  Downregulated


telomerase_RNA


TLC1


9164870


Upregulated and Downregulated


thioredoxin peroxidase TSA1


TSA1


854980


Upregulated


Transporter of POlyamines


TPO1


850631


Upregulated and Downregulated


Ump1p


UMP1


852471


Upregulated and Downregulated


Yeast Frataxin Homolog


YFH1


851437


50%  Downregulated


Yeast Oligomycin Resistance


YOR1


853198


Upregulated and Downregulated


Zillion Different Screens


ZDS2


854931


20%  Downregulated

Reference: HAGR
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