Life extension by compounds in Saccharomyces Cerevisiae

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Name of
Formulation

Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993

Strain

Significance
(Yes: Y, No: N)

Reference

L-Carnitine

1 mM

260


BY4741

N

20550520

Spermidine

4 mM

233


Y

19801973

L-Carnitine

1 mM

140


BY4741

N

20550520

Lithocholic
acid

50 µM

105.5

93

BY4742

Y

30405886

Lithocholic
acid

50 µM

100


BY4741

Y

20622262

Caffeine

0.2-0.4 mM

86


BY4741

Y

18513215

Apple

1 gr

78.5


MCY4/KlLSM4::kanMX4

N

22970337

Resveratrol

10 µM

70


PSY316AT
MATα

Y

12939617

3,5-dihydroxy-4′-acetoxy-trans-stilbene

10 µM

68.2


PSY316ATα

Y

17156081

Glucose

20%

63.1


PSY316

ND

12391171

L-Carnitine

1 mM

62.4


CM39L-11A

N

20550520

Resveratrol

10 µM

60.7


PSY316AT
MATα

Y

12939617

Fisetin

10 µM

55


PSY316AT
MATα

Y

12939617

Chlorophytum
borivilianum polysaccharide extract

10 ng/ml

55


FY631

ND

28727758

3,5-dihydroxy-4′-ethyl-trans-stilbene

10 µM

51.5


PSY316ATα

Y

17156081

L-Carnitine

1 mM

50


CM39L-11A

N

20550520

D-glycerol

1 M

49.8


PSY316

ND

12391171

L-Carnitine

1 mM

42.8


CM39L-11A

N

20550520

Resveratrol

10 µM

41.6


PSY316ATα

Y

17156081

Resveratrol

100 µM

40


PSY316AT
MATα

Y

12939617

Glyceollin
I

12.5 nM

40


Y

24399048

Resveratrol

500 µM

39.5


PSY316AT
MATα

Y

12939617

Chlorophytum
borivilianum polysaccharide extract

100 ng/ml

37


FY631

ND

28727758

Hesperidin

10 µM

36.9


BY4741

Y

22484922

D-xylitol

1 M

36.8


PSY316

ND

12391171

Nicotinamide

5 mM

35.96

50

W303-1A

Y

27320176

Resveratrol

10 µM

33.9


PSY316ATα

Y

17156081

Resveratrol

10 µM

33.8


BY4741

Y

22484922

Butein

10 µM

31


PSY316AT
MATα

Y

12939617

Sorbitol

1 M

29.9


PSY316

ND

12391171

Apple peal

1 gr

28.5


MCY4/KlLSM4::kanMX4

N

22970337

Chlorophytum
borivilianum polysaccharide extract

1 ng/ml

23


FY631

ND

28727758

3,5-dihydroxy-4′-thiomethyl-trans-stilbene

10 µM

22.7


PSY316ATα

Y

17156081

Nolinospiroside
F

3 µM

22.6


K6001

Y

23439553

L-Carnitine

1 mM

21.4


CM39L-11A

N

20550520

Nolinospiroside
F

10 µM

21.3


K6001

Y

23439553

Nicotinamide

1 mM

20.2

19.83

W303-1A

Y

27320176

Nicotinamide
riboside

10 µM

20


BY4741

N

17482543

Resveratrol

10 µg/ml

20


FY631

ND

28727758

Glucose

10%

19.8


PSY316

ND

12391171

Nolinospiroside
F

1 µM

19


K6001

Y

23439553

Resveratrol

10 µM

17.4


K6001

Y

23439553

Hesperidin

5 µM

15.4


BY4741

Y

22484922

Chlorophytum
borivilianum polysaccharide extract

1 µg/ml

15


FY631

ND

28727758

Apple flesh

1 gr

7


MCY4/KlLSM4::kanMX4

N

22970337

Hesperidin

50 µM

4.6


BY4741

Y

22484922

D-glucosamine

0.5 mg/ml

0


W303R

N

11805047

Resveratrol

100 mg/ml

0


BY4741

N

15684413

Resveratrol

100 mg/ml

0


PSY316

N

15684413

Resveratrol

100 mg/ml

0


W303R

N

15684413

Resveratrol

100 µM

-34.8

-25

W303-1A

Y

28412652

Myriocin

600 ng/ml


BY4741

ND

23725375

Myriocin

600 ng/ml


DBY746

ND

23725375

Glyceollin
I

100000 nM


ND

24399048

Glyceollin
I

0.5 nM


Y

24399048

Glyceollin
I

5 nM


Y

24399048

Glyceollin
I

10 nM


Y

24399048

Glyceollin
I

50 nM


Y

24399048

Glyceollin
I

1 nM


Y

24399048

Glyceollin
I

100 nM


Y

24399048

Glyceollin
I

1250 nM


Y

24399048

Glyceollin
I

25000 nM


Y

24399048

Glyceollin
I

25 nM


Y

24399048

Reference: HAGR
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