Life extension by compounds in Drosophila Melanogaster – Part 1

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Name of
Formulation
Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance
(Yes: Y, No: N)

Reference

Carnosine

200 mg/l


D-32

N

12447464

Cocoa

100 g/l
medium


rosy^+5

N

19083435

Cocoa

50 g/l
medium


rosy^+5

Y

19083435

Curcumin

10 mM


Ra

N

23063786

Curcumin

200 mM


Ra

Y

23063786

Curcumin

0.5 mg/g


Wild 1-A

N

23675008

Nordihydroguaiaretic
acid

1 mg/ml


Oregon-R-C

N

25380600

Rhodiola
rosea extract

30 mg/mL
every other day


28.6


ND

9825229

Rhodiola
rosea extract

30 mg/mL
every other day


42.9


ND

9825229

Tartaric
acid

0.1M

-72


Oregon R

ND

110607

Sodium
borate

0.01 M

-69.2


Oregon R

Y

7889879

Calcium
lactate

0.1 M

-66.1


Oregon R

ND

110607

Metformin

100 mM

-66


Dahomey

Y

23077661

Calcium
gluconate

0.1 M

-56.6


Oregon R

ND

110607

Sodium
borate

0.05 M

-51.9


Oregon R

Y

7889879

Paraquat

1 mM

-41.4


Dahomey

Y

27076081

Rutin

800 µM

-38


Canton-S

Y

28389882

Lactic acid

1 M

-32.7


Oregon R

ND

110607

Metformin

100 mM

-31


Dahomey

Y

23077661

Curcumin

100 mM

-23.4


Ra

N

23063786

Curcumin

100 mM

-23.4


Ra

Y

26136617

Rutin

600 µM

-23


Canton-S

Y

28389882

Caffeine

0.03%

-22.86

-11.6

Canton-S

Y

29093334

Metformin

50 mM

-22


Dahomey

Y

23077661

Sodium borate

1 mM

-21.2


Oregon R

Y

7889879

Rotenone

100 µM

-21.14


Dahomey

Y

27076081

Caffeine

0.05%

-17.14

-11.6

Canton-S

Y

29093334

Curcumin

100 mM

-17

-3

Ra

Y

26136617

Curcumin

100 mM

-17

3

Ra

Y

23063786

Rutin

800 µM

-16.66


Canton-S

Y

28389882

Galactose

6.50%

-15.9

-17.1


Y

15547319

Resveratrol

32 µM

-15.4


Canton S

N

17875315

Taurine

1.50%

-14.29

-23.19

Canton-S

Y

29093334

Resveratrol

32 µM

-13.9


Canton S

Y

17875315

Quercetin

1 µM

-13.79

-14.62

Canton S

Y

28066251

Rutin

600 µM

-13.33


Canton-S

Y

28389882

Calcium
gluconate

0.01 M

-13.2


Oregon R

ND

110607

Galactose

6.50%

-12.6

-12.9


Y

15547319

Quercetin

0.5 µM

-12

-13.84

Canton S

Y

28066251

Rhodiola
rosea

30 mg/ml

-11.9

-16.4

IF

Y

24472572

Epicatechin

1 µM

-11.44

-2.21

Canton S

Y

28066251

Sodium
butyrate

100 mM

-10.9


Ra

Y

23044027

Calcium
lactate

0.01 M

-10.7


Oregon R

ND

110607

Curcumin

100 mM

-10.2


Ra

N

23063786

Quercetin

1 µM

-10.2

-8.21

Canton S

Y

28066251

Caffeine

0.01 mg/ml

-10.1


Oregon R

N

8326745

Resveratrol

500 µmol/L

-9.9

-5.28

w1118

N

29324667

Gluconic
acid

1 M

-9.3


Oregon R

ND

110607

Sodium
butyrate

10 mM

-9.1


Ra

N

23044027

Rhodiola
rosea

30 mg/ml

-9.1

-12.2

IF

Y

24472572

Epicatechin

0.3µM

-9.08

-10

Canton S

Y

28066251

Catechin

0.1 mg/ml

-8.5


Oregon R

N

8326745

Resveratrol

10 µM

-8.3


Canton S

Y

17875315

Resveratrol

1000 µM

-8.3


Canton S

N

17875315

Curcumin

100 mM

-8.2

25

Ra

Y

23063786

Resveratrol

10 µM

-7.7


Canton S

Y

17875315

Resveratrol

3.2 µM

-7.4


Dahomey

N

17875315

Resveratrol

32 µM

-7.4


Dahomey

N

17875315

Resveratrol

1000 µM

-7.4


Dahomey

N

17875315

Resveratrol

200 µM

-7.4


Dahomey

N

17875315

Metformin

25 mM

-7


Dahomey

Y

23077661

Resveratrol

1 µM

-6.8


Canton S

N

17875315

Epicatechin

0.3µM

-6.49

-5.22

Canton S

Y

28066251

Sodium
butyrate

100 mM

-6.3


Ra

N

23044027

Sodium
butyrate

10 mM

-6.3


Ra

N

23044027

Metformin

50 mM

-6


Dahomey

N

23077661

Metformin

10 mM

-6


Dahomey

N

23077661

Metformin

25 mM

-6


Dahomey

N

23077661

Resveratrol

1 µM

-5.6


Dahomey

N

17875315

Resveratrol

10 µM

-5.6


Dahomey

Y

17875315

Resveratrol

1000 µM

-5.6


Dahomey

N

17875315

Gluconic
acid

0.1 M

-5.2


Oregon R

ND

110607

Catechin

1 mg/ml

-5.1


Oregon R

N

8326745

Catechin

0.01 mg/ml

-5.1


Oregon R

N

8326745

Quercetin

0.3µM

-5.09

-8.2

Canton S

Y

28066251

Quercetin

0.5 µM

-4.55

-6.7

Canton S

Y

28066251

Resveratrol

10 µM

-4.5


Canton S

N

17875315

Resveratrol

200 µM

-4.5


Canton S

N

17875315

Metformin

2.5 mM

-4


Dahomey

N

23077661

Epicatechin

1 µM

-3.78

-4.48

Canton S

Y

28066251

Calcium
gluconate

0.001 M

-3.7


Oregon R

ND

110607

Resveratrol

1 µM

-3.7


Dahomey

N

17875315

Resveratrol

100 µM

-3.7


Dahomey

N

17875315

Resveratrol

10 µM

-3.4


Canton S

N

17875315

Resveratrol

1 µM

-3.4


Canton S

N

17875315

Resveratrol

32 µM

-3.4


Canton S

Y

17875315

Resveratrol

100 µM

-3.4


Canton S

N

17875315

Resveratrol

3.2 µM

-3.4


Canton S

N

17875315

Resveratrol

100 µM

-3.4


Canton S

N

17875315

Resveratrol

200 µM

-3.4


Canton S

N

17875315

Resveratrol

1000 µM

-3.4


Canton S

N

17875315

Resveratrol

3.2 µM

-3.4


Dahomey

N

17875315

Resveratrol

100 µM

-3.4


Dahomey

N

17875315

Resveratrol

32 µM

-3.4


Dahomey

N

17875315

Caffeine

1 mg/ml

-3.3


Oregon R

N

8326745

Metformin

10 mM

-3


Dahomey

N

23077661

Resveratrol

3.2 µM

-3


Dahomey

N

17875315

Tannic acid

1 mg/ml

-2.9


Oregon R

N

8326745

Resveratrol

3.2 µM

-2.8


Canton S

N

17875315

Reference: HAGR
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