Life extension by compounds in Caenorhabditis Elegans – Part 4

Aging
* Reviews

Anti-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae

Aging
* Humans
* Homo Sapiens
* Mus Musculus

Senescence
* Overexpressed
* Underexpressed

Induced Senescence
* Oncogene
* Replicative
* Stress

Inhibiting Senescence
* Oncogene
* Replicative
* Stress

Variants of longevity
* Human

Pro-longevity
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus musculus
* Saccharomyces cerevisiae
Fitness
* Saccharomyces cerevisiae

Dietary restriction
* Overexpressed
* Underexpressed

Dietary restriction
* Caenorhabditis elegans
* Drosophila melanogaster
* Mus Musculus
* Saccharomyces cerevisiae
* Schizosaccharomyces pombe

Dietary restriction
* Overexpressed
* Underexpressed
* Overexpressed- Underexpressed
Life extension
* Caenorhabditis elegans
* Drosophila Melanogaster
* Mus Musculus
* Other Species
* Rattus Norvegicus
* Saccharomyces cerevisiae

Post-radiation SASP (Day 10)
* Renal Epithelial Cells
* Human Fibroblasts
* Exosome SASP - Human Fibroblasts

Post-Atazanivir SASP (Day 14)
* Human Fibroblasts

RAS induced SASP (Day 7)
* Fibroblasts
* Exosome SASP - Fibroblasts
Part 1 Part 2 Part 3 Part 4
Arctigenin 10 µM

6.7

N2 Y 26141518
Nicotinamide 100 µM

6.5

6

N2 Y 24077178
trans-2,40,5-trihydroxystilbene 100 µM

6.44

N2 Y 27882602
4-hydroxy-E-globularinin 200 µM

6.4

N2 Y 23000058
Butylated hydroxyanisole 25 µM

6.38

N2 Y 28054425
Metformin 100 mM

6.3

N2 N 24889636
Resveratrol 1 µM

6.3

9.1

N2 N 25976661
18α-Glycyrrhetinic acid 10 µg/ml

6.25

N2 N 26886723
Calycosin 50 µM

6.24

N2 Y 28434978
Resveratrol 50 µM

6.24

18.75

N2 Y 27683245
N-acetyl-L-cysteine 1 mM

6.1

9.5

N2 CGCb strain N 26039957
Coenzyme Q10 50 µg/ml

6

N2 Y 14706236
Colanic acid

6

N2 Y 28622510
Colanic acid

6

N2 Y 28622510
Colanic acid

6

N2 Y 28622510
Colanic acid

6

isp-1(qm150) N 28622510
DL-lactate 5 mM

6

N2 Y 25643626
Galactose 10 mM

6

N2 Y 25643626
Leucine 5 mM

6

N2 Y 25643626
Lysine 10 mM

6

N2 Y 25643626
Minocycline 50 µM

6

N2 Y 30479271
Minocycline 50 µM

6

N2 Y 30479271
Taurine 5 mM

6

N2 Y 25643626
Tryptophan 5 mM

6

N2 Y 25643626
Xylose 10 mM

6

N2 Y 25643626
Silydianin 10 µM

5.88

N2 Y 28039083
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

5.8

N2 Y 26433219
Proline 5 µM

5.8

N2 Y 22482728
1,3-dimemethyl Xan 50 µg/mL

5.54

N2 Y 30061824
N-nitrosodimethylamine 50 µM

5.5

N2 Y 25556763
N-acetyl-L-cysteine 2 mM

5.2

9.5

N2 CGCb strain N 26039957
Sesame Cake Peptides 50 µg/ml

5.2

3.57

N2 Y 27381188
1-methylxanthine 50 µg/mL

5.05

N2 Y 30061824
Asparagine 5 mM

5

N2 Y 25643626
Beta-alanine 5 mM

5

N2 N 25643626
Minocycline 50 µM

5

N2 N 30479271
Piericidin A 100 nM

5

N2 Y 24199155
Platinum nanoparticles 10 ppb

5

N2 N 21737933
Resveratrol 10 µg/ml

5

CB5586 Y 28727758
Sorbitol 2%

5

N2 N 19883616
SU 4312 88 µM

5

Y 24134630
Tyrosine 5 mM

5

N2 Y 25643626
Dehydroabietic acid 50 µM

4.8

8.3

N2 N 25976661
Epigallocatechin-3-gallate 25 µM

4.8

4.8

N2 N 17156833
Polygonum multiflorum Extract 100 µg/mL

4.8

N2 N 30036983
Diethyl Maleate 100 µM

4.64

2.33

N2 Y 28086197
β-Santalol 64 µM

4.64

8.33

N2 Y 30319772
Silymarin 10 µM

4.55

N2 Y 28039083
α-Santalol 16 µM

4.33

0

N2 N 30319772
Withanolide A 2 µM

4.32

7.59

N2 Y 26956478
Argyreia boseana 1 mg/mL

4.25

N2 Y 30448258
East Indian sandalwood oil 48 µ/mL

4.22

4.34

N2 N 30319772
Lonicera japonica 50 µg/mL

4.04

N2 N 30266681
Alanine 5 mM

4

N2 N 25643626
Carnosine 100 µM

4

N2 Y 25643626
Colanic acid

4

N2 N 28622510
Colanic acid

4

nuo-6(qm200) N 28622510
d-Allulose 5 mM

4

N2 Y 28965946
Histidine 1 mM

4

N2 N 25643626
L-histidine methyl ester 10 mM

4

N2 N 25643626
Methionine 1 mM

4

N2 N 25643626
Succinate 10 mM

4

N2 N 25643626
Vitamin E 400 µg/ml

4

N2 N 3374177
Platinum nanoparticles 2 ppb

3.9

N2 N 21737933
β-Santalol 32µM

3.78

8.33

N2 N 30319772
trans-3,5-dimethoxy-4-fluoro-4'-hydroxystilbene 100 µM

3.63

4.76

N2 Y 27882602
L-theanine 0.1 µM

3.6

4.4

N2 Y 22422488
Resveratrol 100 µM

3.4

N2 N 17875315
Colanic acid

3

N2 N 28622510
DL-isocitrate 1 mM

3

N2 N 25643626
DL-lactate 1 mM

3

N2 N 25643626
EUK-8 0.05 mM

3

N2 N 12521609
Glycine 5 mM

3

N2 N 25643626
Inositol 1 mM

3

N2 Y 25643626
Isoleucine 1 mM

3

N2 N 25643626
Isoleucine 5 mM

3

N2 N 25643626
Isoleucine 10 mM

3

N2 Y 25643626
N-acetyl-l-histidine 100 µM

3

N2 N 25643626
Ornithine 100 µM

3

N2 N 25643626
Oxoline 500 µM

3

12

N2 Y 21765926
Plumbagin 2.5 µM

3

5

N2 N 21765926
Plumbagin 5 µM

3

3

N2 N 21765926
Threonine 5 mM

3

N2 N 25643626
Vitamin E 80 ug/ml

2.9

N2 Y 10843344
β-Santalol 8 µM

2.66

8.33

N2 N 30319772
α-Santalol 8 µM

2.57

-4.16

N2 N 30319772
2,3-dehydrosilybin 5 µM

2.16

N2 Y 28039083
Cysteine 10 mM

2

N2 N 25643626
DL-lactate 10 mM

2

N2 N 25643626
Geldanamycin 20 µM

2

N2 N 26676933
Naphthazarin 50 µM

2

0

N2 N 21765926
Oxoline 100 µM

2

5

N2 N 21765926
Oxoline 50 µM

2

1

N2 N 21765926
Oxoline 100 µM

2

-8

N2 N 21765926
Quercetin 50 µM

2

N2 N 22493606
Tyrosine 10 mM

2

N2 N 25643626
Platinum nanoparticles 50 ppb

1.7

N2 N 21737933
Polygonum multiflorum Extract 10 µg/mL

1.5

N2 N 30036983
Agmatine 100 µM

1

N2 N 25643626
Asparagine 1 mM

1

N2 N 25643626
Caprylate 100 µM

1

N2 N 25643626
Carnosine 10 µM

1

N2 N 25643626
Colanic acid

1

isp-1(qm150) N 28622510
Colanic acid

1

nuo-6(qm200) N 28622510
Galactose 1 mM

1

N2 N 25643626
Plumbagin 1 µM

1

3

N2 N 21765926
Plumbagin 100 µM

1

2

N2 N 21765926
Putrescine 100 µM

1

N2 N 25643626
Ribose 10 mM

1

N2 N 25643626
Tannic acid 300 µM

1

N2 N 22493606
Tryptophan 10 mM

1

N2 N 25643626
East Indian sandalwood oil 3 µ/mL

0.94

4.34

N2 N 30319772
α-Santalol 64 µM

0.94

0

N2 N 30319772
3-methylxanthine 50 µg/mL

0.93

N2 N 30061824
Resveratrol 100 µM

0.87

N2 Y 27882602
Xanthine 50 µg/mL

0.82

N2 N 30061824
Sesamin 25 µg

0.8

N2 N 24549958
α-Santalol 4 µM

0.63

-4.16

N2 N 30319772
Luteolin 10 µM

0.47

2.76

N2 Y 29375370
GYY4137 100 µM

0.4

N2 N 24093496
Folic acid 50 µM

0.2

N2 N 26546011
Lithium Chloride 10 mM

0.1

0

JK1107 ND 24398558
4-dafachronic acid 250 nM

0

2.6

N2 Y 17360327
Ascorbic acid 80 µg/ml

0

N2 N 3374177
Caffeine 5 mM

0

N2 N 26696878
Caffeine 5 mM

0

N2 N 26696878
Colanic acid

0

isp-1(qm150) N 28622510
Glucose 2%

0

0

N2 N 26764305
Glucose 2%

0

N2 N 19883616
Plumbagin 7.5 µM

0

0

N2 N 21765926
Threonine 1 mM

0

N2 Y 25643626
Luteolin 5 µM

-0.6

8.28

N2 Y 29375370
Ascorbic acid 10 mM

-0.76

-12.9

N2 N 27683245
3,7-dimethylxanthine 50 µg/mL

-0.84

N2 N 30061824
EUK-8 0.05 mM

-0.9

N2 N 12521609
EUK-8 0.05 mM

-0.9

N2 N 12521609
Colanic acid

-1

N2 N 28622510
Valine 10 mM

-1

N2 Y 25643626
Luteolin 1 µM

-1.54

8.28

N2 Y 29375370
Citrate 10 mM

-2

N2 N 25643626
Sorbitol 2%

-2

N2 N 19883616
β-Santalol 4 µM

-2.73

0

N2 N 30319772
D-glutamate 10 mM

-3

N2 N 25643626
Plumbagin 50 µM

-3

-6

N2 N 21765926
Ascorbic acid 5 mM

-3.59

6.45

N2 Y 27683245
Argyreia boseana 0.1 mg/mL

-3.8

N2 N 30448258
Creatine 1 mM

-4

N2 Y 25643626
Glycine 10 mM

-4

N2 N 25643626
Taurine 10 mM

-4

N2 Y 25643626
Wortmannin 1 µM

-4.1

N2 Y 23543623
Ellagic acid 50 µM

-4.3

N2 N 27400265
Luteolin 0.5 µM

-4.5

-2.03

N2 Y 29375370
Metformin 25 mM

-4.7

N2 N 24889636
Caprylate 5 mM

-5

N2 Y 25643626
Colanic acid

-5

nuo-6(qm200) N 28622510
Argyreia boseana 0.01 mg/mL

-5.4

N2 Y 30448258
EUK-8 0.05 mM

-5.7

N2 N 12521609
Glucose 1%

-5.88

12.5

N2 N 26764305
Glucose 2%

-5.88

12.5

N2 Y 26764305
Glutamine 10 mM

-6

N2 Y 25643626
EUK-8 0.05 mM

-6.1

N2 Y 12521609
Diethyl Maleate 1 mM

-6.68

-6.4

N2 Y 28086197
Quercetin 250 µM

-7

N2 Y 22493606
Trimethadione 4 mg/ml

-7

-10

N2 N 15653505
D-glucose 50 mM

-7.75

-0.9

N2 Y 17908557
Epigallocatechin-3-gallate 800 µM

-7.9

-10.85

N2 Y 28992589
Glutamate 10 mM

-8

N2 Y 25643626
Menadione 100 µM

-8.72

-6.36

N2 Y 28086197
7-methyl-Dehydrosilybin 10 µM

-9

N2 Y 28039083
Glucose 2%

-9

N2 Y 19883616
Ornithine 10 mM

-10

N2 Y 25643626
EUK-8 0.5 mM

-10.7

N2 Y 12521609
Glucose 2%

-11

N2 Y 19883616
Plumbagin 100 µM

-11

-13

N2 Y 21765926
Tannic acid 400 µM

-11

N2 Y 22493606
Caffeine 7.5 mM

-11.6

N2 Y 24764514
Fish oil 2 mg/plate

-12.8

N2 Y 23526170
EUK-8 0.05 mM

-12.9

N2 Y 12521609
Putrescine 10 mM

-13

N2 Y 25643626
Caffeine 5 mM

-13.6

N2 Y 24764514
Zinc Sulfate 500 µM

-14

N2 Y 27078872
Glucose 2%

-15

N2 Y 19883616
Glucose 2%

-15

N2 Y 19883616
L-theanine 10 mM

-15

N2 Y 25643626
Glucose 2%

-16

N2 Y 19883616
Plumbagin 100 µM

-16

-15

N2 Y 21765926
Epigallocatechin-3-gallate 1 mM

-16.6

-13.14

N2 Y 28992589
Glucose 2%

-17

N2 Y 19883616
Glucose 102%

-17

N2 Y 19883616
2,4-pyridinedicarboxylic acid 10 mM

-17.13

N2 Y 26729005
Glucose 4%

-17.65

-8.33

N2 Y 26764305
Caprylate 10 mM

-18

N2 Y 25643626
Creatine 10 mM

-18

N2 Y 25643626
Glucose 400 mM

-18.69

N2 Y 27776915
Glucose 2%

-19

N2 Y 19883616
Glucose 2%

-19

N2 Y 19883616
Agmatine 10 mM

-20

N2 Y 25643626
Creatine 5 mM

-20

N2 Y 25643626
Glucose 2%

-20

N2 Y 19883616
EUK-8 0.5 mM

-21.1

N2 Y 12521609
Glucose 2%

-23

N2 Y 19883616
Glycerol 1%

-23

N2 Y 19883616
Plumbagin 150 µM

-23

N2 Y 21765926
Nitrophenyl piperazine containing compound 1 500 µM

-23.08

N2 Y 27220516
Glucose 4%

-23.6

-17.24

N2 Y 26764305
Glucose 2%

-23.75

-20.97

N2 Y 26764305
Glucose 2%

-24

N2 Y 19883616
Glycerol 1%

-24

N2 Y 19883616
Caffeine 30 mM

-24.4

N2 Y 24764514
Asparagine 10 mM

-25

N2 Y 25643626
Pyruvate 8 mM

-25.35

N2 Y 26729005
EUK-8 0.5 mM

-26.5

N2 Y 12521609
EUK-8 0.5 mM

-26.6

N2 Y 12521609
DL-isocitrate 10 mM

-28

N2 Y 25643626
Glucose 2%

-28

N2 Y 19883616
Glucose 2%

-31

N2 Y 19883616
Fructose 555 mM

-31.79

N2 Y 27680107
EUK-8 0.5 mM

-33.1

N2 Y 12521609
Glycerol 1%

-36

N2 Y 19883616
Caffeine 50 mM

-40.9

N2 Y 24764514
Glucose 111 mM

-46.8

N2 Y 27680107
Caffeine 30 mM

-60

N2 Y 26696878
EUK-8 5 mM

-81

N2 Y 12521609
Plumbagin 500 µM

-81

N2 Y 21765926
Caffeine 75 mM

-82.8

N2 Y 24764514
EUK-8 5 mM

-83.7

N2 Y 12521609
EUK-8 5 mM

-83.9

N2 Y 12521609
Plumbagin 200 µM

-84

N2 Y 21765926
Plumbagin 250 µM

-86

N2 Y 21765926
Plumbagin 300 µM

-86

N2 Y 21765926
Caffeine 100 mM

-89.5

N2 Y 24764514
Plumbagin 400 µM

-90

N2 Y 21765926
Plumbagin 250 µM

-91

N2 Y 21765926
Plumbagin 500 µM

-91

N2 Y 21765926
Caffeine 45 mM

-92

N2 Y 26696878
Caffeine 60 mM

-96

N2 Y 26696878
A.sinensis root peptides 2 mg/ml N2 ND 26941890
Ascorbic acid 25 µL Liposomes + 240 µg ascorbic acid

50

N2 Y 19580823
Glutathione 25 µL Liposomes + 360 µg glutathione

50

N2 Y 19580823
N-acetyl-L-cysteine 25 µL Liposomes + 100 µg NAC

42.9

N2 Y 19580823
Pine Bark extract 10 µg/mL

5.2

N2 Y 19350411
Psoralea corylifolia extract 10 µg/mL

9.8

N2 Y 19350411
Trimethadione 25 µL Liposomes + 0.6mg trimethadione

50

N2 Y 19580823
Reference: HAGR