Life extension by compounds in Caenorhabditis Elegans – Part 4

[raw]

Aging

* Reviews

Anti-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae

Aging

* Humans

* Homo Sapiens

* Mus Musculus

Senescence

* Overexpressed

* Underexpressed

Induced Senescence

* Oncogene

* Replicative

* Stress


Inhibiting Senescence

* Oncogene

* Replicative

* Stress


Variants of longevity

* Human


Pro-longevity

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus musculus

* Saccharomyces cerevisiae
Fitness

* Saccharomyces cerevisiae


Dietary restriction

* Overexpressed

* Underexpressed


Dietary restriction

* Caenorhabditis elegans

* Drosophila melanogaster

* Mus Musculus

* Saccharomyces cerevisiae

* Schizosaccharomyces pombe


Dietary restriction

* Overexpressed

* Underexpressed

* Overexpressed- Underexpressed
Life extension

* Caenorhabditis elegans

* Drosophila Melanogaster

* Mus Musculus

* Other Species

* Rattus Norvegicus

* Saccharomyces cerevisiae


Post-radiation SASP (Day 10)

* Renal Epithelial Cells

* Human Fibroblasts

* Exosome SASP – Human Fibroblasts


Post-Atazanivir SASP (Day 14)

* Human Fibroblasts


RAS induced SASP (Day 7)

* Fibroblasts

* Exosome SASP – Fibroblasts

Part 1
Part 2
Part 3
Part 4


Arctigenin

10 µM

6.7


N2

Y

26141518

Nicotinamide

100 µM

6.5

6


N2

Y

24077178

trans-2,40,5-trihydroxystilbene

100 µM

6.44


N2

Y

27882602

4-hydroxy-E-globularinin

200 µM

6.4


N2

Y

23000058

Butylated
hydroxyanisole

25 µM

6.38


N2

Y

28054425

Metformin

100 mM

6.3


N2

N

24889636

Resveratrol

1 µM

6.3

9.1


N2

N

25976661

18α-Glycyrrhetinic
acid

10 µg/ml

6.25


N2

N

26886723

Calycosin

50 µM

6.24


N2

Y

28434978

Resveratrol

50 µM

6.24

18.75


N2

Y

27683245

N-acetyl-L-cysteine

1 mM

6.1

9.5


N2 CGCb
strain

N

26039957

Coenzyme
Q10

50 µg/ml

6


N2

Y

14706236

Colanic
acid

6


N2

Y

28622510

Colanic
acid

6


N2

Y

28622510

Colanic
acid

6


N2

Y

28622510

Colanic
acid

6


isp-1(qm150)

N

28622510

DL-lactate

5 mM

6


N2

Y

25643626

Galactose

10 mM

6


N2

Y

25643626

Leucine

5 mM

6


N2

Y

25643626

Lysine

10 mM

6


N2

Y

25643626

Minocycline

50 µM

6


N2

Y

30479271

Minocycline

50 µM

6


N2

Y

30479271

Taurine

5 mM

6


N2

Y

25643626

Tryptophan

5 mM

6


N2

Y

25643626

Xylose

10 mM

6


N2

Y

25643626

Silydianin

10 µM

5.88


N2

Y

28039083

Acacetin
7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside

5.8


N2

Y

26433219

Proline

5 µM

5.8


N2

Y

22482728

1,3-dimemethyl
Xan

50 µg/mL

5.54


N2

Y

30061824

N-nitrosodimethylamine

50 µM

5.5


N2

Y

25556763

N-acetyl-L-cysteine

2 mM

5.2

9.5


N2 CGCb
strain

N

26039957

Sesame Cake
Peptides

50 µg/ml

5.2

3.57


N2

Y

27381188

1-methylxanthine

50 µg/mL

5.05


N2

Y

30061824

Asparagine

5 mM

5


N2

Y

25643626

Beta-alanine

5 mM

5


N2

N

25643626

Minocycline

50 µM

5


N2

N

30479271

Piericidin
A

100 nM

5


N2

Y

24199155

Platinum
nanoparticles

10 ppb

5


N2

N

21737933

Resveratrol

10 µg/ml

5


CB5586

Y

28727758

Sorbitol

2%

5


N2

N

19883616

SU 4312

88 µM

5


Y

24134630

Tyrosine

5 mM

5


N2

Y

25643626

Dehydroabietic
acid

50 µM

4.8

8.3


N2

N

25976661

Epigallocatechin-3-gallate

25 µM

4.8

4.8


N2

N

17156833

Polygonum
multiflorum Extract

100 µg/mL

4.8


N2

N

30036983

Diethyl Maleate

100 µM

4.64

2.33


N2

Y

28086197

β-Santalol

64 µM

4.64

8.33


N2

Y

30319772

Silymarin

10 µM

4.55


N2

Y

28039083

α-Santalol

16 µM

4.33

0


N2

N

30319772

Withanolide
A

2 µM

4.32

7.59


N2

Y

26956478

Argyreia
boseana

1 mg/mL

4.25


N2

Y

30448258

East Indian
sandalwood oil

48 µ/mL

4.22

4.34


N2

N

30319772

Lonicera
japonica

50 µg/mL

4.04


N2

N

30266681

Alanine

5 mM

4


N2

N

25643626

Carnosine

100 µM

4


N2

Y

25643626

Colanic
acid

4


N2

N

28622510

Colanic
acid

4


nuo-6(qm200)

N

28622510

d-Allulose

5 mM

4


N2

Y

28965946

Histidine

1 mM

4


N2

N

25643626

L-histidine
methyl ester

10 mM

4


N2

N

25643626

Methionine

1 mM

4


N2

N

25643626

Succinate

10 mM

4


N2

N

25643626

Vitamin E

400 µg/ml

4


N2

N

3374177

Platinum
nanoparticles

2 ppb

3.9


N2

N

21737933

β-Santalol

32µM

3.78

8.33


N2

N

30319772

trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene

100 µM

3.63

4.76


N2

Y

27882602

L-theanine

0.1 µM

3.6

4.4


N2

Y

22422488

Resveratrol

100 µM

3.4


N2

N

17875315

Colanic
acid

3


N2

N

28622510

DL-isocitrate

1 mM

3


N2

N

25643626

DL-lactate

1 mM

3


N2

N

25643626

EUK-8

0.05 mM

3


N2

N

12521609

Glycine

5 mM

3


N2

N

25643626

Inositol

1 mM

3


N2

Y

25643626

Isoleucine

1 mM

3


N2

N

25643626

Isoleucine

5 mM

3


N2

N

25643626

Isoleucine

10 mM

3


N2

Y

25643626

N-acetyl-l-histidine

100 µM

3


N2

N

25643626

Ornithine

100 µM

3


N2

N

25643626

Oxoline

500 µM

3

12


N2

Y

21765926

Plumbagin

2.5 µM

3

5


N2

N

21765926

Plumbagin

5 µM

3

3


N2

N

21765926

Threonine

5 mM

3


N2

N

25643626

Vitamin E

80 ug/ml

2.9


N2

Y

10843344

β-Santalol

8 µM

2.66

8.33


N2

N

30319772

α-Santalol

8 µM

2.57

-4.16


N2

N

30319772

2,3-dehydrosilybin

5 µM

2.16


N2

Y

28039083

Cysteine

10 mM

2


N2

N

25643626

DL-lactate

10 mM

2


N2

N

25643626

Geldanamycin

20 µM

2


N2

N

26676933

Naphthazarin

50 µM

2

0


N2

N

21765926

Oxoline

100 µM

2

5


N2

N

21765926

Oxoline

50 µM

2

1


N2

N

21765926

Oxoline

100 µM

2

-8


N2

N

21765926

Quercetin

50 µM

2


N2

N

22493606

Tyrosine

10 mM

2


N2

N

25643626

Platinum
nanoparticles

50 ppb

1.7


N2

N

21737933

Polygonum
multiflorum Extract

10 µg/mL

1.5


N2

N

30036983

Agmatine

100 µM

1


N2

N

25643626

Asparagine

1 mM

1


N2

N

25643626

Caprylate

100 µM

1


N2

N

25643626

Carnosine

10 µM

1


N2

N

25643626

Colanic
acid

1


isp-1(qm150)

N

28622510

Colanic
acid

1


nuo-6(qm200)

N

28622510

Galactose

1 mM

1


N2

N

25643626

Plumbagin

1 µM

1

3


N2

N

21765926

Plumbagin

100 µM

1

2


N2

N

21765926

Putrescine

100 µM

1


N2

N

25643626

Ribose

10 mM

1


N2

N

25643626

Tannic acid

300 µM

1


N2

N

22493606

Tryptophan

10 mM

1


N2

N

25643626

East Indian
sandalwood oil

3 µ/mL

0.94

4.34


N2

N

30319772

α-Santalol

64 µM

0.94

0


N2

N

30319772

3-methylxanthine

50 µg/mL

0.93


N2

N

30061824

Resveratrol

100 µM

0.87


N2

Y

27882602

Xanthine

50 µg/mL

0.82


N2

N

30061824

Sesamin

25 µg

0.8


N2

N

24549958

α-Santalol

4 µM

0.63

-4.16


N2

N

30319772

Luteolin

10 µM

0.47

2.76


N2

Y

29375370

GYY4137

100 µM

0.4


N2

N

24093496

Folic acid

50 µM

0.2


N2

N

26546011

Lithium
Chloride

10 mM

0.1

0


JK1107

ND

24398558

4-dafachronic
acid

250 nM

0

2.6


N2

Y

17360327

Ascorbic
acid

80 µg/ml

0


N2

N

3374177

Caffeine

5 mM

0


N2

N

26696878

Caffeine

5 mM

0


N2

N

26696878

Colanic
acid

0


isp-1(qm150)

N

28622510

Glucose

2%

0

0


N2

N

26764305

Glucose

2%

0


N2

N

19883616

Plumbagin

7.5 µM

0

0


N2

N

21765926

Threonine

1 mM

0


N2

Y

25643626

Luteolin

5 µM

-0.6

8.28


N2

Y

29375370

Ascorbic
acid

10 mM

-0.76

-12.9


N2

N

27683245

3,7-dimethylxanthine

50 µg/mL

-0.84


N2

N

30061824

EUK-8

0.05 mM

-0.9


N2

N

12521609

EUK-8

0.05 mM

-0.9


N2

N

12521609

Colanic
acid

-1


N2

N

28622510

Valine

10 mM

-1


N2

Y

25643626

Luteolin

1 µM

-1.54

8.28


N2

Y

29375370

Citrate

10 mM

-2


N2

N

25643626

Sorbitol

2%

-2


N2

N

19883616

β-Santalol

4 µM

-2.73

0


N2

N

30319772

D-glutamate

10 mM

-3


N2

N

25643626

Plumbagin

50 µM

-3

-6


N2

N

21765926

Ascorbic
acid

5 mM

-3.59

6.45


N2

Y

27683245

Argyreia
boseana

0.1 mg/mL

-3.8


N2

N

30448258

Creatine

1 mM

-4


N2

Y

25643626

Glycine

10 mM

-4


N2

N

25643626

Taurine

10 mM

-4


N2

Y

25643626

Wortmannin

1 µM

-4.1


N2

Y

23543623

Ellagic
acid

50 µM

-4.3


N2

N

27400265

Luteolin

0.5 µM

-4.5

-2.03


N2

Y

29375370

Metformin

25 mM

-4.7


N2

N

24889636

Caprylate

5 mM

-5


N2

Y

25643626

Colanic acid

-5


nuo-6(qm200)

N

28622510

Argyreia
boseana

0.01 mg/mL

-5.4


N2

Y

30448258

EUK-8

0.05 mM

-5.7


N2

N

12521609

Glucose

1%

-5.88

12.5


N2

N

26764305

Glucose

2%

-5.88

12.5


N2

Y

26764305

Glutamine

10 mM

-6


N2

Y

25643626

EUK-8

0.05 mM

-6.1


N2

Y

12521609

Diethyl
Maleate

1 mM

-6.68

-6.4


N2

Y

28086197

Quercetin

250 µM

-7


N2

Y

22493606

Trimethadione

4 mg/ml

-7

-10


N2

N

15653505

D-glucose

50 mM

-7.75

-0.9


N2

Y

17908557

Epigallocatechin-3-gallate

800 µM

-7.9

-10.85


N2

Y

28992589

Glutamate

10 mM

-8


N2

Y

25643626

Menadione

100 µM

-8.72

-6.36


N2

Y

28086197

7-methyl-Dehydrosilybin

10 µM

-9


N2

Y

28039083

Glucose

2%

-9


N2

Y

19883616

Ornithine

10 mM

-10


N2

Y

25643626

EUK-8

0.5 mM

-10.7


N2

Y

12521609

Glucose

2%

-11


N2

Y

19883616

Plumbagin

100 µM

-11

-13


N2

Y

21765926

Tannic acid

400 µM

-11


N2

Y

22493606

Caffeine

7.5 mM

-11.6


N2

Y

24764514

Fish oil

2 mg/plate

-12.8


N2

Y

23526170

EUK-8

0.05 mM

-12.9


N2

Y

12521609

Putrescine

10 mM

-13


N2

Y

25643626

Caffeine

5 mM

-13.6


N2

Y

24764514

Zinc
Sulfate

500 µM

-14


N2

Y

27078872

Glucose

2%

-15


N2

Y

19883616

Glucose

2%

-15


N2

Y

19883616

L-theanine

10 mM

-15


N2

Y

25643626

Glucose

2%

-16


N2

Y

19883616

Plumbagin

100 µM

-16

-15


N2

Y

21765926

Epigallocatechin-3-gallate

1 mM

-16.6

-13.14


N2

Y

28992589

Glucose

2%

-17


N2

Y

19883616

Glucose

102%

-17


N2

Y

19883616

2,4-pyridinedicarboxylic
acid

10 mM

-17.13


N2

Y

26729005

Glucose

4%

-17.65

-8.33


N2

Y

26764305

Caprylate

10 mM

-18


N2

Y

25643626

Creatine

10 mM

-18


N2

Y

25643626

Glucose

400 mM

-18.69


N2

Y

27776915

Glucose

2%

-19


N2

Y

19883616

Glucose

2%

-19


N2

Y

19883616

Agmatine

10 mM

-20


N2

Y

25643626

Creatine

5 mM

-20


N2

Y

25643626

Glucose

2%

-20


N2

Y

19883616

EUK-8

0.5 mM

-21.1


N2

Y

12521609

Glucose

2%

-23


N2

Y

19883616

Glycerol

1%

-23


N2

Y

19883616

Plumbagin

150 µM

-23


N2

Y

21765926

Nitrophenyl
piperazine containing compound 1

500 µM

-23.08


N2

Y

27220516

Glucose

4%

-23.6

-17.24


N2

Y

26764305

Glucose

2%

-23.75

-20.97


N2

Y

26764305

Glucose

2%

-24


N2

Y

19883616

Glycerol

1%

-24


N2

Y

19883616

Caffeine

30 mM

-24.4


N2

Y

24764514

Asparagine

10 mM

-25


N2

Y

25643626

Pyruvate

8 mM

-25.35


N2

Y

26729005

EUK-8

0.5 mM

-26.5


N2

Y

12521609

EUK-8

0.5 mM

-26.6


N2

Y

12521609

DL-isocitrate

10 mM

-28


N2

Y

25643626

Glucose

2%

-28


N2

Y

19883616

Glucose

2%

-31


N2

Y

19883616

Fructose

555 mM

-31.79


N2

Y

27680107

EUK-8

0.5 mM

-33.1


N2

Y

12521609

Glycerol

1%

-36


N2

Y

19883616

Caffeine

50 mM

-40.9


N2

Y

24764514

Glucose

111 mM

-46.8


N2

Y

27680107

Caffeine

30 mM

-60


N2

Y

26696878

EUK-8

5 mM

-81


N2

Y

12521609

Plumbagin

500 µM

-81


N2

Y

21765926

Caffeine

75 mM

-82.8


N2

Y

24764514

EUK-8

5 mM

-83.7


N2

Y

12521609

EUK-8

5 mM

-83.9


N2

Y

12521609

Plumbagin

200 µM

-84


N2

Y

21765926

Plumbagin

250 µM

-86


N2

Y

21765926

Plumbagin

300 µM

-86


N2

Y

21765926

Caffeine

100 mM

-89.5


N2

Y

24764514

Plumbagin

400 µM

-90


N2

Y

21765926

Plumbagin

250 µM

-91


N2

Y

21765926

Plumbagin

500 µM

-91


N2

Y

21765926

Caffeine

45 mM

-92


N2

Y

26696878

Caffeine

60 mM

-96


N2

Y

26696878

A.sinensis
root peptides

2 mg/ml


N2

ND

26941890

Ascorbic
acid

25 µL
Liposomes + 240 µg ascorbic acid

50


N2

Y

19580823

Glutathione

25 µL
Liposomes + 360 µg glutathione

50


N2

Y

19580823

N-acetyl-L-cysteine

25 µL
Liposomes + 100 µg NAC

42.9


N2

Y

19580823

Pine Bark
extract

10 µg/mL

5.2


N2

Y

19350411

Psoralea
corylifolia extract

10 µg/mL

9.8


N2

Y

19350411

Trimethadione

25 µL
Liposomes + 0.6mg trimethadione

50


N2

Y

19580823

Reference: HAGR


[/raw]