Genes that inhibit replicative senescence

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Entrez ID

Symbol

Method Used To Cause Senescence

Cell type

Cell line

Cancer Line

47

ACLY

Knockout

Dermal fibroblast

Primary cell

No

444

ASPH

Knockdown

Liver cancer

FOCUS, HepG2, Huh7

Yes

472

ATM

Knockout

Foreskin fibroblast, Lung fibroblast

BJ, MRC-5, WI-38

No

6790

AURKA

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

9531

BAG3

Knockdown

Glioma, Laryngeal cancer

A172, HEp2

Yes

604

BCL6

Overexpression

B-cell

Primary cell

No

648

BMI1

Knockout, Overexpression

Foreskin fibroblast, Lung fibroblast, Skin fibroblast

82-6, BJ, WI-38

No

10950

BTG3

Knockdown

Lung fibroblast

IMR-90, WI-38

No

23492

CBX7

Knockdown, Overexpression

Keratinocyte, Lung fibroblast

Primary cell, WI-38

No

57332

CBX8

Overexpression

Fibroblast

TIG-3

No

983

CDK1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

8099

CDK2AP1

Knockdown

Dermal fibroblast

Primary cell

No

1019

CDK4

Overexpression

Foreskin fibroblast

BJ

No

1021

CDK6

Overexpression

Foreskin fibroblast

BJ

No

1058

CENPA

Knockdown

Lung fibroblast

TIG-3

No

1452

CSNK1A1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

1457

CSNK2A1

Knockdown

Lung fibroblast

IMR-90

No

8727

CTNNAL1

Knockdown

Lung cancer, Squamous carcinoma

A549, OC2

Yes

7913

DEK

Overexpression

Foreskin keratinocyte

Primary cell

No

54487

DGCR8

Knockdown

Lung fibroblast

IMR-90

No

1660

DHX9

Knockdown

Lung fibroblast

MRC-5

No

1746

DLX2

Overexpression

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90

No

84661

DPY30

Knockout

Lung fibroblast

IMR-90

No

80824

DUSP16

Knockdown

Embryonic kidney, Liver cancer

HEK293FT, HepG2, PLC/PRF/5

Yes

1845

DUSP3

Knockdown

Cervical cancer

HeLa

Yes

2021

ENDOG

Knockdown

Endothelial

Primary cell

No

2042

EPHA3

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

2353

FOS

Overexpression

Lung fibroblast

WI-38

No

2305

FOXM1

Knockdown

Gallbladder cancer

GBC-SD

Yes

2309

FOXO3

Knockdown

Dermal fibroblast

Primary cell

No

8087

FXR1

Knockdown, Overexpression

Laryngeal cancer, Tongue cancer

CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B

Yes

2539

G6PD

Knockout

Foreskin fibroblast

Primary cell

No

2597

GAPDH

Knockdown

Lung cancer

A549

Yes

2720

GLB1

Knockdown

Foreskin fibroblast

Primary cell

No

9759

HDAC4

Knockout, Overexpression

Lung fibroblast

2BS

No

3096

HIVEP1

Knockdown

Foreskin fibroblast

Primary cell

No

55355

HJURP

Knockdown, Overexpression

Dermal fibroblast, Umbilical vein endothelial

Primary cell

No

3146

HMGB1

Knockdown

Lung cancer, Melanoma

A375, G361, NCI-H1299, SK-MEL-28

Yes

3397

ID1

Overexpression

Dermal endothelial, Umbilical vein endothelial

Primary cell

No

3489

IGFBP6

Knockdown, Overexpression

Fibroblast

Primary cell

No

10765

KDM5B

Knockdown

Colon cancer

Colo201, DLD1, HCT116

Yes

57650

KIAA1524

Knockdown

Gastric cancer

AGS, BGC-823, HGC-27, KATO-III

Yes

9365

KL

Knockdown

Lung fibroblast

MRC-5, WI-38

No

9113

LATS1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

3958

LGALS3

Knockdown

Gastric cancer

AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2

Yes

4085

MAD2L1

Knockdown

Breast epithelial, Lung fibroblast

IMR-90, MCF-10A

No

5606

MAP2K3

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

11184

MAP4K1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

54708

MARCH5

Knockdown

Cervical cancer

HeLa

Yes

4190

MDH1

Knockdown

Dermal fibroblast, Lung fibroblast

IMR-90, Primary cell

No

4204

MECP2

Knockdown

Mesenchymal stem

Primary cell

No

4318

MMP9

Knockdown

Medulloblastoma

DAOY

Yes

4638

MYLK

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

79923

NANOG

Overexpression

Dermal fibroblast, Fibroblast

NIH3T3, Oct4-GiP

Yes

4750

NEK1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

10783

NEK6

Overexpression

Bladder cancer, Lung cancer

EJ, NCI-H1299

Yes

4780

NFE2L2

Knockout

Lung fibroblast

HFL-1

No

23598

PATZ1

Knockdown, Overexpression

Umbilical vein endothelial

Primary cell

No

25913

POT1

Knockdown

Lung fibroblast

IMR-90

No

5495

PPM1B

Knockdown

Lung fibroblast

IMR-90

No

8493

PPM1D

Overexpression

Mesenchymal stem

Primary cell

No

55170

PRMT6

Knockdown

Breast cancer, Breast epithelial

MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3

Yes

27339

PRPF19

Overexpression

Dermal fibroblast, Umbilical vein endothelial

Primary cell

No

5693

PSMB5

Overexpression

Multipotent bone marrow stromal

Primary cell

No

10213

PSMD14

Knockdown

Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer

A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75

Yes

5885

RAD21

Knockdown

Breast cancer

MDA-MB-231

No

5948

RBP2

Knockout

Cervical cancer, Gastric cancer

AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa

Yes

9978

RBX1

Knockdown

Glioblastoma, Lung cancer

U87

Yes

26156

RSL1D1

Knockout, Overexpression

Lung fibroblast

2BS

No

10856

RUVBL2

Knockdown

Kidney cancer

A498, KRC/Y

Yes

280636

SELENOH

Knockdown

Lung fibroblast

MRC-5

No

29843

SENP1

Knockdown

Foreskin fibroblast

Primary cell

No

59343

SENP2

Knockdown

Foreskin fibroblast

Primary cell

No

57337

SENP7

Knockdown

Foreskin fibroblast

Primary cell

No

6446

SGK1

Overexpression

Umbilical vein endothelial

Primary cell

No

23411

SIRT1

Overexpression

Lung fibroblast

2BS

No

51548

SIRT6

Knockdown

Chondrocyte

NHAC-kn

No

6495

SIX1

Knockdown

Lung fibroblast

IMR-90

No

9194

SLC16A7

Knockdown

Colon cancer, Gastric cancer

DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480

Yes

6597

SMARCA4

Knockdown

Mesenchymal stem

Primary cell

No

23049

SMG1

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

6615

SNAI1

Knockdown

Prostate cancer

LNCaP, PC-3

Yes

6647

SOD1

Knockdown

Lung fibroblast

WI-38, WI38-SV40

No

6909

TBX2

Knockdown

Melanoma

B16

Yes

7012

TERC

Knockdown

Cervical cancer

HeLa

Yes

7014

TERF2

Knockout

Neuroblastoma

SH-SY5Y

Yes

7015

TERT

Overexpression

Foreskin fibroblast, Retinal pigment epithelial

BJ, RPE-340

No

7027

TFDP1

Knockdown

Cervical cancer, Lung cancer, Lung fibroblast

A549, HeLa, WI-38

Yes

7114

TMSB4X

Overexpression

Nucleus pulposus

Primary cell

No

8741

TNFSF13

Knockdown

Colon cancer

SW480

Yes

7175

TPR

Knockdown

Cervical cancer, Melanoma, Osteosarcoma

A375, HeLa, U2OS

Yes

79054

TRPM8

Knockdown

Pancreatic cancer

BxPC-3, PANC-1

Yes

7295

TXN

Knockdown

Foreskin fibroblast

BJ, BJE-LT

No

7422

VEGFA

Overexpression

Dermal endothelial

Primary cell

No

7472

WNT2

Knockdown

Lung fibroblast

WI-38

No

11059

WWP1

Knockdown, Overexpression

Lung fibroblast

2BS, WI-38

No

10413

YAP1

Knockdown

Foreskin fibroblast, Lung fibroblast

BJ, IMR-90, WI-38

No

64393

ZMAT3

Knockdown

Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma

HEK293T, MCF-7, U2OS

Yes

7707

ZNF148

Knockout

Lung cancer

NCI-H460

Yes

51474

LIMA1

Knockdown

Lung fibroblast

IMR-90

No

4116

MAGOH

Knockdown

Lung fibroblast

IMR-90

No

55110

MAGOHB

Knockdown

Lung fibroblast

IMR-90

No

64175

P3H1

Knockdown

Lung fibroblast

IMR-90

No

9682

KDM4A

Knockdown

Lung cancer

A549

Yes

283455

KSR2

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

123169

LEO1

Overexpression

Lung fibroblast

2BS

No

5286

PIK3C2A

Knockdown

Embryonic kidney, Retinal pigment epithelial

HEK293T, hTERT-RPE1

Yes

Reference: HAGR
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