Genes that inhibit replicative senescence

Entrez ID Symbol Method Used To Cause Senescence Cell type Cell line Cancer Line
47 ACLY Knockout Dermal fibroblast Primary cell No
444 ASPH Knockdown Liver cancer FOCUS, HepG2, Huh7 Yes
472 ATM Knockout Foreskin fibroblast, Lung fibroblast BJ, MRC-5, WI-38 No
6790 AURKA Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
9531 BAG3 Knockdown Glioma, Laryngeal cancer A172, HEp2 Yes
604 BCL6 Overexpression B-cell Primary cell No
648 BMI1 Knockout, Overexpression Foreskin fibroblast, Lung fibroblast, Skin fibroblast 82-6, BJ, WI-38 No
10950 BTG3 Knockdown Lung fibroblast IMR-90, WI-38 No
23492 CBX7 Knockdown, Overexpression Keratinocyte, Lung fibroblast Primary cell, WI-38 No
57332 CBX8 Overexpression Fibroblast TIG-3 No
983 CDK1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
8099 CDK2AP1 Knockdown Dermal fibroblast Primary cell No
1019 CDK4 Overexpression Foreskin fibroblast BJ No
1021 CDK6 Overexpression Foreskin fibroblast BJ No
1058 CENPA Knockdown Lung fibroblast TIG-3 No
1452 CSNK1A1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
1457 CSNK2A1 Knockdown Lung fibroblast IMR-90 No
8727 CTNNAL1 Knockdown Lung cancer, Squamous carcinoma A549, OC2 Yes
7913 DEK Overexpression Foreskin keratinocyte Primary cell No
54487 DGCR8 Knockdown Lung fibroblast IMR-90 No
1660 DHX9 Knockdown Lung fibroblast MRC-5 No
1746 DLX2 Overexpression Foreskin fibroblast, Lung fibroblast BJ, IMR-90 No
84661 DPY30 Knockout Lung fibroblast IMR-90 No
80824 DUSP16 Knockdown Embryonic kidney, Liver cancer HEK293FT, HepG2, PLC/PRF/5 Yes
1845 DUSP3 Knockdown Cervical cancer HeLa Yes
2021 ENDOG Knockdown Endothelial Primary cell No
2042 EPHA3 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
2353 FOS Overexpression Lung fibroblast WI-38 No
2305 FOXM1 Knockdown Gallbladder cancer GBC-SD Yes
2309 FOXO3 Knockdown Dermal fibroblast Primary cell No
8087 FXR1 Knockdown, Overexpression Laryngeal cancer, Tongue cancer CAL27, SCC25, SCC4, SCC9, UMSCC-11A, UMSCC-11B, UMSCC-74A, UMSCC-74B Yes
2539 G6PD Knockout Foreskin fibroblast Primary cell No
2597 GAPDH Knockdown Lung cancer A549 Yes
2720 GLB1 Knockdown Foreskin fibroblast Primary cell No
9759 HDAC4 Knockout, Overexpression Lung fibroblast 2BS No
3096 HIVEP1 Knockdown Foreskin fibroblast Primary cell No
55355 HJURP Knockdown, Overexpression Dermal fibroblast, Umbilical vein endothelial Primary cell No
3146 HMGB1 Knockdown Lung cancer, Melanoma A375, G361, NCI-H1299, SK-MEL-28 Yes
3397 ID1 Overexpression Dermal endothelial, Umbilical vein endothelial Primary cell No
3489 IGFBP6 Knockdown, Overexpression Fibroblast Primary cell No
10765 KDM5B Knockdown Colon cancer Colo201, DLD1, HCT116 Yes
57650 KIAA1524 Knockdown Gastric cancer AGS, BGC-823, HGC-27, KATO-III Yes
9365 KL Knockdown Lung fibroblast MRC-5, WI-38 No
9113 LATS1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
3958 LGALS3 Knockdown Gastric cancer AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2 Yes
4085 MAD2L1 Knockdown Breast epithelial, Lung fibroblast IMR-90, MCF-10A No
5606 MAP2K3 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
11184 MAP4K1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
54708 MARCH5 Knockdown Cervical cancer HeLa Yes
4190 MDH1 Knockdown Dermal fibroblast, Lung fibroblast IMR-90, Primary cell No
4204 MECP2 Knockdown Mesenchymal stem Primary cell No
4318 MMP9 Knockdown Medulloblastoma DAOY Yes
4638 MYLK Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
79923 NANOG Overexpression Dermal fibroblast, Fibroblast NIH3T3, Oct4-GiP Yes
4750 NEK1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
10783 NEK6 Overexpression Bladder cancer, Lung cancer EJ, NCI-H1299 Yes
4780 NFE2L2 Knockout Lung fibroblast HFL-1 No
23598 PATZ1 Knockdown, Overexpression Umbilical vein endothelial Primary cell No
25913 POT1 Knockdown Lung fibroblast IMR-90 No
5495 PPM1B Knockdown Lung fibroblast IMR-90 No
8493 PPM1D Overexpression Mesenchymal stem Primary cell No
55170 PRMT6 Knockdown Breast cancer, Breast epithelial MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3 Yes
27339 PRPF19 Overexpression Dermal fibroblast, Umbilical vein endothelial Primary cell No
5693 PSMB5 Overexpression Multipotent bone marrow stromal Primary cell No
10213 PSMD14 Knockdown Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, Mia PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75 Yes
5885 RAD21 Knockdown Breast cancer MDA-MB-231 No
5948 RBP2 Knockout Cervical cancer, Gastric cancer AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa Yes
9978 RBX1 Knockdown Glioblastoma, Lung cancer U87 Yes
26156 RSL1D1 Knockout, Overexpression Lung fibroblast 2BS No
10856 RUVBL2 Knockdown Kidney cancer A498, KRC/Y Yes
280636 SELENOH Knockdown Lung fibroblast MRC-5 No
29843 SENP1 Knockdown Foreskin fibroblast Primary cell No
59343 SENP2 Knockdown Foreskin fibroblast Primary cell No
57337 SENP7 Knockdown Foreskin fibroblast Primary cell No
6446 SGK1 Overexpression Umbilical vein endothelial Primary cell No
23411 SIRT1 Overexpression Lung fibroblast 2BS No
51548 SIRT6 Knockdown Chondrocyte NHAC-kn No
6495 SIX1 Knockdown Lung fibroblast IMR-90 No
9194 SLC16A7 Knockdown Colon cancer, Gastric cancer DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480 Yes
6597 SMARCA4 Knockdown Mesenchymal stem Primary cell No
23049 SMG1 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
6615 SNAI1 Knockdown Prostate cancer LNCaP, PC-3 Yes
6647 SOD1 Knockdown Lung fibroblast WI-38, WI38-SV40 No
6909 TBX2 Knockdown Melanoma B16 Yes
7012 TERC Knockdown Cervical cancer HeLa Yes
7014 TERF2 Knockout Neuroblastoma SH-SY5Y Yes
7015 TERT Overexpression Foreskin fibroblast, Retinal pigment epithelial BJ, RPE-340 No
7027 TFDP1 Knockdown Cervical cancer, Lung cancer, Lung fibroblast A549, HeLa, WI-38 Yes
7114 TMSB4X Overexpression Nucleus pulposus Primary cell No
8741 TNFSF13 Knockdown Colon cancer SW480 Yes
7175 TPR Knockdown Cervical cancer, Melanoma, Osteosarcoma A375, HeLa, U2OS Yes
79054 TRPM8 Knockdown Pancreatic cancer BxPC-3, PANC-1 Yes
7295 TXN Knockdown Foreskin fibroblast BJ, BJE-LT No
7422 VEGFA Overexpression Dermal endothelial Primary cell No
7472 WNT2 Knockdown Lung fibroblast WI-38 No
11059 WWP1 Knockdown, Overexpression Lung fibroblast 2BS, WI-38 No
10413 YAP1 Knockdown Foreskin fibroblast, Lung fibroblast BJ, IMR-90, WI-38 No
64393 ZMAT3 Knockdown Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma HEK293T, MCF-7, U2OS Yes
7707 ZNF148 Knockout Lung cancer NCI-H460 Yes
51474 LIMA1 Knockdown Lung fibroblast IMR-90 No
4116 MAGOH Knockdown Lung fibroblast IMR-90 No
55110 MAGOHB Knockdown Lung fibroblast IMR-90 No
64175 P3H1 Knockdown Lung fibroblast IMR-90 No
9682 KDM4A Knockdown Lung cancer A549 Yes
283455 KSR2 Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
123169 LEO1 Overexpression Lung fibroblast 2BS No
5286 PIK3C2A Knockdown Embryonic kidney, Retinal pigment epithelial HEK293T, hTERT-RPE1 Yes
Reference: HAGR