Genes that inhibit oncogene induced senescence

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Entrez ID


Symbol


Method Used To Cause Senescence


Cell type


Cell line


Cancer Line


4101


MAGEA2

Overexpression


Foreskin fibroblast


BJ


No


4609


MYC

Knockout


Fibroblast


LF1


No


6829


SUPT5H

Knockout


Cervical cancer


HeLa


Yes


7398


USP1

Knockdown


Foreskin fibroblast, Lung fibroblast


BJ, WI-38


No


7486


WRN

Knockdown


Fibroblast, WRN syndrome fibroblast


AG00780, AG03141


Yes


7490


WT1

Knockout


Lung cancer


NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727


Yes


7101


NR2E1

Knockout


Lung fibroblast, Neural Stem, Prostate epithelial


IMR-90, WI-38


No

Reference: HAGR
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