Age induced gene changes – Homo Sapiens

Part 1 Part 2 Part 3 Part 4
Gene Symbol (Name) Description Change gender Age change starts Age change ends Tissues Percentage change P value References
0910001L09Rik (RIKEN cDNA 0910001L09 gene)   Male and Female 8 24 Muscle -6.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
1110002B05Rik (RIKEN cDNA 1110002B05 gene)   Male and Female 6 22 Liver 5.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
1110008P14Rik (RIKEN cDNA 1110008P14 gene)   Male and Female 5 30 Anatomical System -2.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
1500001M20Rik (RIKEN cDNA 1500001M20 gene)   Male and Female 3 23 Hematological System -8.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
1600015I10Rik (RIKEN cDNA 1600015I10 gene)   Male and Female 5 22 Brain -53.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
1600029I14Rik (RIKEN cDNA 1600029I14 gene)   Male and Female 3 23 Hematological System 16.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
1700006E09Rik (RIKEN cDNA 1700006E09 gene)   Male and Female 3 23 Hematological System 88.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
1700056E22Rik (RIKEN cDNA 1700056E22 gene)   Male and Female 2 26 Lung 91.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
1810044D09Rik (RIKEN cDNA 1810044D09 gene)   Male and Female 3 23 Hematological System 4.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
2310033P09Rik (RIKEN cDNA 2310033P09 gene)   Male and Female 3 23 Hematological System -1.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
2310037I24Rik (RIKEN cDNA 2310037I24 gene)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
2410017P09Rik (RIKEN cDNA 2410017P09 gene)   Male and Female 8 24 Muscle -5.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
2610005L07Rik (RIKEN cDNA 2610005L07 gene)   Male and Female 5 22 Brain 2.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
2610018G03Rik (RIKEN cDNA 2610018G03 gene)   Male and Female 8 24 Muscle 5.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
2610201A13Rik (RIKEN cDNA 2610201A13 gene)   Male and Female 2 15 Hippocampus 2.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
2700007P21Rik (RIKEN cDNA 2700007P21 gene)   Male and Female 8 24 Muscle -6.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
2810021B07Rik (RIKEN cDNA 2810021B07 gene)   Male and Female 2 26 Lung 5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
2810038L03Rik (RIKEN cDNA 2810038L03 gene)   Male and Female 5 22 Brain 382.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
2810405K02Rik (RIKEN cDNA 2810405K02 gene)   Male and Female 8 24 Muscle -4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
3830431G21Rik (RIKEN cDNA 3830431G21 gene)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
4732418C07Rik (RIKEN cDNA 4732418C07 gene)   Male and Female 8 24 Muscle 3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
4833411C07Rik (RIKEN cDNA 4833411C07 gene)   Male and Female 5 22 Brain 114.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
4930453L07Rik (RIKEN cDNA 4930453L07 gene)   Male and Female 5 22 Brain -51.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
4930456G14Rik (RIKEN cDNA 4930456G14 gene)   Male and Female 2 26 Lung 55.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
4930517J16Rik (RIKEN cDNA 4930517J16 gene)   Male and Female 5 30 Anatomical System 146.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
4930578I06Rik (RIKEN cDNA 4930578I06 gene)   Male and Female 3 23 Hematological System 58.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
4933433G19Rik (RIKEN cDNA 4933433G19 gene)   Male and Female 3 23 Hematological System -12.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
5430427O19Rik (RIKEN cDNA 5430427O19 gene)   Male and Female 5 22 Brain -84.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
8430408G22Rik (RIKEN cDNA 8430408G22 gene)   Male and Female 2 26 Lung 8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
8430436O14Rik (RIKEN cDNA 8430436O14 gene)   Male and Female 2 26 Lung -4.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
9030418K01Rik (RIKEN cDNA 9030418K01 gene)   Male and Female 3 23 Hematological System 7.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
A130082M07Rik (RIKEN cDNA A130082M07 gene)   Male and Female 2 26 Lung 19.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
A230006K03Rik (RIKEN cDNA A230006K03 gene)   Male and Female 8 24 Muscle -16.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
A230038B01Rik (RIKEN cDNA A230038B01 gene)   Male and Female 5 22 Brain 240.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
A930005H10Rik (RIKEN cDNA A930005H10 gene)   Male and Female 3 23 Hematological System 7.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
AACS (acetoacetyl-CoA synthetase) Using a linear mixed model, differential expression with age was identified in AACS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AADAC (arylacetamide deacetylase) Using a linear mixed model, differential expression with age was identified in AADAC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Abat (4-aminobutyrate aminotransferase)   Male and Female 3 23 Hematological System 45.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ABCA1 (ATP-binding cassette, sub-family A (ABC1), member 1) Using a linear mixed model, differential expression with age was identified in ABCA1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4) Using a linear mixed model, differential expression with age was identified in ABCA4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) Using a linear mixed model, differential expression with age was identified in ABCA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABCA8 (ATP-binding cassette, sub-family A (ABC1), member 8) Comparison of DNA methylation showed a significantly decreased methylation level of ABCA8 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -23.4 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
ABCA8 (ATP-binding cassette, sub-family A (ABC1), member 8) Comparison of DNA methylation showed a significantly decreased methylation level of ABCA8 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -25.0 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) Using a linear mixed model, differential expression with age was identified in ABCB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1)   Male and Female 2 26 Lung 2.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ABCC4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) Using a linear mixed model, differential expression with age was identified in ABCC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABHD12 (abhydrolase domain containing 12) Using a linear mixed model, differential expression with age was identified in ABHD12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABHD12B (abhydrolase domain containing 12B) Using a linear mixed model, differential expression with age was identified in ABHD12B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Abhd14a (abhydrolase domain containing 14A)   Male and Female 8 24 Muscle -3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ABHD14A (abhydrolase domain containing 14A)   Male and Female 26 106 Brain -3.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ABHD14A (abhydrolase domain containing 14A) Using a linear mixed model, differential expression with age was identified in ABHD14A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABHD14A (abhydrolase domain containing 14A) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ABHD14A and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
ABHD5 (abhydrolase domain containing 5) Using a linear mixed model, differential expression with age was identified in ABHD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABI2 (abl-interactor 2)   Male and Female 26 106 Brain -18.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ABI3BP (ABI family, member 3 (NESH) binding protein) Using a linear mixed model, differential expression with age was identified in ABI3BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ABLIM1 (actin binding LIM protein 1)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ABLIM2 (actin binding LIM protein family, member 2)   Male and Female 20 75 Skeletal Muscle 5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)
ACACA (acetyl-CoA carboxylase alpha) Gene expression showed a significant (p<E-3) increase in the expression of ACACA in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 63.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ACACA (acetyl-CoA carboxylase alpha) Using a linear mixed model, differential expression with age was identified in ACACA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACACA (acetyl-CoA carboxylase alpha) Using a linear mixed model, differential expression with age was identified in ACACA in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACAD10 (acyl-CoA dehydrogenase family, member 10) Using a linear mixed model, differential expression with age was identified in ACAD10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACAD11 (acyl-CoA dehydrogenase family, member 11) Using a linear mixed model, differential expression with age was identified in ACAD11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACAD8 (acyl-CoA dehydrogenase family, member 8) Using a linear mixed model, differential expression with age was identified in ACAD8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACADL (acyl-CoA dehydrogenase, long chain) Using a linear mixed model, differential expression with age was identified in ACADL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACADM (acyl-CoA dehydrogenase, C-4 to C-12 straight chain) Using a linear mixed model, differential expression with age was identified in ACADM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACADVL (acyl-CoA dehydrogenase, very long chain) Using a linear mixed model, differential expression with age was identified in ACADVL in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACAT2 (acetyl-CoA acetyltransferase 2) Using a linear mixed model, differential expression with age was identified in ACAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Accn1 (amiloride-sensitive cation channel 1, neuronal (degenerin))   Male and Female 2 26 Lung 57.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ACE2 (angiotensin I converting enzyme 2) Using a linear mixed model, differential expression with age was identified in ACE2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACER3 (alkaline ceramidase 3) Using a linear mixed model, differential expression with age was identified in ACER3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACIN1 (apoptotic chromatin condensation inducer 1) Using a linear mixed model, differential expression with age was identified in ACIN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACLY (ATP citrate lyase) Using a linear mixed model, differential expression with age was identified in ACLY in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACO1 (aconitase 1, soluble) Using a linear mixed model, differential expression with age was identified in ACO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACOT11 (acyl-CoA thioesterase 11) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ACOT11 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Acot7 (acyl-CoA thioesterase 7)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ACOT7 (acyl-CoA thioesterase 7) Using a linear mixed model, differential expression with age was identified in ACOT7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACSBG1 (acyl-CoA synthetase bubblegum family member 1) Using a linear mixed model, differential expression with age was identified in ACSBG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACSL5 (acyl-CoA synthetase long-chain family member 5) Using a linear mixed model, differential expression with age was identified in ACSL5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Acsm2 (acyl-CoA synthetase medium-chain family member 2)   Male and Female 3 23 Hematological System -29.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ACSM3 (acyl-CoA synthetase medium-chain family member 3) Using a linear mixed model, differential expression with age was identified in ACSM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Acss1 (acyl-CoA synthetase short-chain family member 1)   Male and Female 2 15 Hippocampus -2.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
ACSS2 (acyl-CoA synthetase short-chain family member 2) Using a linear mixed model, differential expression with age was identified in ACSS2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACSS2 (acyl-CoA synthetase short-chain family member 2) Using a linear mixed model, differential expression with age was identified in ACSS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACTA1 (actin, alpha 1, skeletal muscle)   Male and Female 26 106 Brain -16.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Acta1 (actin, alpha 1, skeletal muscle)   Male and Female 5 25 Skeletal Muscle 55.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
ACTB (actin, beta)   Male and Female 26 106 Brain -4.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Actc1 (actin, alpha, cardiac muscle 1)   Male and Female 8 24 Muscle -13.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ACTC1 (actin, alpha, cardiac muscle 1)   Male and Female 20 75 Skeletal Muscle 8.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ACTC1 (actin, alpha, cardiac muscle 1) Using a linear mixed model, differential expression with age was identified in ACTC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACTG2 (actin, gamma 2, smooth muscle, enteric) Using a linear mixed model, differential expression with age was identified in ACTG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACTL6A (actin-like 6A)   Male and Female 26 106 Brain 21.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ACTN3 (actinin, alpha 3) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ACTN3 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
ACTR5 (ARP5 actin-related protein 5 homolog (yeast)) Using a linear mixed model, differential expression with age was identified in ACTR5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Actr6 (ARP6 actin-related protein 6 homolog (yeast))   Male and Female 5 25 Skeletal Muscle 7.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
ACVR1B (activin A receptor, type IB) Gene expression showed a significant (p<E-3) increase in the expression of ACVR1B in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 51.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ACVR1B (activin A receptor, type IB) Using a linear mixed model, differential expression with age was identified in ACVR1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACVR2A (activin A receptor, type IIA) Using a linear mixed model, differential expression with age was identified in ACVR2A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ACYP1 (acylphosphatase 1, erythrocyte (common) type) Using a linear mixed model, differential expression with age was identified in ACYP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADA (adenosine deaminase) Using a linear mixed model, differential expression with age was identified in ADA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADA (adenosine deaminase) Using a linear mixed model, differential expression with age was identified in ADA in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Adam25 (a disintegrin and metallopeptidase domain 25 (testase 2))   Male and Female 3 23 Hematological System 9.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5)   Male and Female 20 75 Skeletal Muscle 7.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ADAMTSL3 (ADAMTS-like 3) Using a linear mixed model, differential expression with age was identified in ADAMTSL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADAP2 (ArfGAP with dual PH domains 2) Using a linear mixed model, differential expression with age was identified in ADAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADARB1 (adenosine deaminase, RNA-specific, B1) Using a linear mixed model, differential expression with age was identified in ADARB1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADCK1 (aarF domain containing kinase 1) Using a linear mixed model, differential expression with age was identified in ADCK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADCK2 (aarF domain containing kinase 2) Using a linear mixed model, differential expression with age was identified in ADCK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADCK3 (aarF domain containing kinase 3) Using a linear mixed model, differential expression with age was identified in ADCK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADCK5 (aarF domain containing kinase 5) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of ADCK5 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
ADIPOR2 (adiponectin receptor 2) Using a linear mixed model, differential expression with age was identified in ADIPOR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ADM (adrenomedullin) Using a linear mixed model, differential expression with age was identified in ADM in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Adssl1 (adenylosuccinate synthetase like 1)   Male and Female 5 25 Skeletal Muscle -13.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of AGAP1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) Using a linear mixed model, differential expression with age was identified in AGAP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AGBL5 (ATP/GTP binding protein-like 5)   Male and Female 0 102 Cerebellum 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
AGBL5 (ATP/GTP binding protein-like 5)   Male and Female 0 102 Frontal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
AGBL5 (ATP/GTP binding protein-like 5)   Male and Female 0 102 Pons 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
AGBL5 (ATP/GTP binding protein-like 5)   Male and Female 0 102 Temporal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) Using a linear mixed model, differential expression with age was identified in AGPAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) Using a linear mixed model, differential expression with age was identified in AGPAT3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AGTPBP1 (ATP/GTP binding protein 1) Using a linear mixed model, differential expression with age was identified in AGTPBP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AGTRAP (angiotensin II receptor-associated protein) Using a linear mixed model, differential expression with age was identified in AGTRAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AHCTF1 (AT hook containing transcription factor 1)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1)   Male and Female 5 22 Brain 1.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1)   Male and Female 8 24 Muscle 2.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
AHCYL2 (adenosylhomocysteinase-like 2) Using a linear mixed model, differential expression with age was identified in AHCYL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AHNAK (AHNAK nucleoprotein)   Male and Female 26 106 Brain 13.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Ahnak2 (AHNAK nucleoprotein 2)   Male and Female 3 23 Hematological System 81.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
AHSA2 (AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast))   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
AHSP (alpha hemoglobin stabilizing protein) Using a linear mixed model, differential expression with age was identified in AHSP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AI317395 (expressed sequence AI317395)   Male and Female 2 26 Lung 6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
AI447881 (expressed sequence AI447881)   Male and Female 2 26 Lung 6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
AI596487 (expressed sequence AI596487)   Male and Female 5 25 Skeletal Muscle -1.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
AIF1 (allograft inflammatory factor 1) Using a linear mixed model, differential expression with age was identified in AIF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AIFM1 (apoptosis-inducing factor, mitochondrion-associated, 1) Using a linear mixed model, differential expression with age was identified in AIFM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AJUBA (ajuba LIM protein) Using a linear mixed model, differential expression with age was identified in AJUBA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AK4P3 (adenylate kinase 4 pseudogene 3) Gene expression showed a significant (p<E-3) increase in the expression of AK4P3 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 54.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
AKAP7 (A kinase (PRKA) anchor protein 7)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
AKAP8 (A kinase (PRKA) anchor protein 8) Using a linear mixed model, differential expression with age was identified in AKAP8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Akr1c18 (aldo-keto reductase family 1, member C18)   Male and Female 4 15 Cochlea -20.0 <0.001 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326)
AKR1C3 (aldo-keto reductase family 1, member C3) Comparison of DNA methylation showed a significantly decreased methylation level of AKR1C3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -19.3 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
AKR1C3 (aldo-keto reductase family 1, member C3) Using a linear mixed model, differential expression with age was identified in AKR1C3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AKR7A2 (aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)) Using a linear mixed model, differential expression with age was identified in AKR7A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALAS1 (aminolevulinate, delta-, synthase 1)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ALAS1 (aminolevulinate, delta-, synthase 1) Using a linear mixed model, differential expression with age was identified in ALAS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Alb (albumin)   Male and Female 5 22 Brain 88.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
Alcam (activated leukocyte cell adhesion molecule)   Male and Female 3 23 Hematological System 15.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ALDH1A1 (aldehyde dehydrogenase 1 family, member A1) Comparison of DNA methylation showed a significantly decreased methylation level of ALDH1A1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -30.3 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
Aldh1a1 (aldehyde dehydrogenase family 1, subfamily A1)   Male and Female 8 24 Muscle 6.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ALDH1A2 (aldehyde dehydrogenase 1 family, member A2) Using a linear mixed model, differential expression with age was identified in ALDH1A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALDH1L1 (aldehyde dehydrogenase 1 family, member L1) Using a linear mixed model, differential expression with age was identified in ALDH1L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALDH3B2 (aldehyde dehydrogenase 3 family, member B2) Using a linear mixed model, differential expression with age was identified in ALDH3B2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALDH6A1 (aldehyde dehydrogenase 6 family, member A1) Using a linear mixed model, differential expression with age was identified in ALDH6A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALDH9A1 (aldehyde dehydrogenase 9 family, member A1)   Male and Female 26 106 Brain 10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ALDOB (aldolase B, fructose-bisphosphate) Using a linear mixed model, differential expression with age was identified in ALDOB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALG13 (ALG13, UDP-N-acetylglucosaminyltransferase subunit) Gene expression showed a significant (p<E-3) decrease in the expression of ALG13 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -42.2 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ALOX15B (arachidonate 15-lipoxygenase, type B) Using a linear mixed model, differential expression with age was identified in ALOX15B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Alox5 (arachidonate 5-lipoxygenase) 5-LOX mRNA expression decreased in heart from age 2 to 22 month. Male 2 22 Heart     2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386)
Alox5 (arachidonate 5-lipoxygenase) 5-LOX mRNA expression level increased in frontal cortex from age 2 to 22 month. Male 2 22 Heart     2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386)
Alox5 (arachidonate 5-lipoxygenase) 5-LOX promoter-5’UTR DNA methylation increased in heart from age 2 to 22 month. Male 2 22 Heart     2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386)
Alox5 (arachidonate 5-lipoxygenase) 5-LOX promoter-5’UTR DNA methylation increased in cerebellum from age 2 to 22 month. Male 2 22 Cerebellum     2715: Dzitoyeva et al. (2009) "5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice." Neural Plast. 2009:209596 (20052386)
ALOX5 (arachidonate 5-lipoxygenase) Using a linear mixed model, differential expression with age was identified in ALOX5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALOX5AP (arachidonate 5-lipoxygenase-activating protein) Using a linear mixed model, differential expression with age was identified in ALOX5AP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALPK1 (alpha-kinase 1) Using a linear mixed model, differential expression with age was identified in ALPK1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALPK2 (alpha-kinase 2)   Male and Female 27 92 Kidney 20.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
ALPK3 (alpha-kinase 3)   Male and Female 20 75 Skeletal Muscle 6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ALS2CL (ALS2 C-terminal like) Using a linear mixed model, differential expression with age was identified in ALS2CL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ALX4 (ALX homeobox 4) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of ALX4 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
AMACR (alpha-methylacyl-CoA racemase) Using a linear mixed model, differential expression with age was identified in AMACR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ammecr1l (AMME chromosomal region gene 1-like)   Male and Female 2 26 Lung -2.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
AMOT (angiomotin)   Male and Female 26 106 Brain 10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
AMT (aminomethyltransferase) Using a linear mixed model, differential expression with age was identified in AMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Amy1 (amylase 1, salivary)   Male and Female 8 24 Muscle 12.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ANAPC11 (anaphase promoting complex subunit 11) Using a linear mixed model, differential expression with age was identified in ANAPC11 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANAPC4 (anaphase promoting complex subunit 4) Gene expression showed a significant (p<E-3) decrease in the expression of ANAPC4 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -35.48 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ANAPC4 (anaphase promoting complex subunit 4) Using a linear mixed model, differential expression with age was identified in ANAPC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANAPC5 (anaphase promoting complex subunit 5) Using a linear mixed model, differential expression with age was identified in ANAPC5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANGEL2 (angel homolog 2 (Drosophila)) Gene expression showed a significant (p<E-3) decrease in the expression of ANGEL2 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -65.28 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ANGEL2 (angel homolog 2 (Drosophila)) Using a linear mixed model, differential expression with age was identified in ANGEL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Angpt1 (angiopoietin 1)   Male and Female 8 24 Muscle -16.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ANGPTL2 (angiopoietin-like 2) Using a linear mixed model, differential expression with age was identified in ANGPTL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ank (progressive ankylosis)   Male and Female 2 15 Hippocampus 1.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
ANK2 (ankyrin 2, neuronal)   Male and Female 26 106 Brain -20.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ANKAR (ankyrin and armadillo repeat containing) Using a linear mixed model, differential expression with age was identified in ANKAR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKEF1 (ankyrin repeat and EF-hand domain containing 1) Using a linear mixed model, differential expression with age was identified in ANKEF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKMY2 (ankyrin repeat and MYND domain containing 2) Using a linear mixed model, differential expression with age was identified in ANKMY2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKRA2 (ankyrin repeat, family A (RFXANK-like), 2) Using a linear mixed model, differential expression with age was identified in ANKRA2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKRD13A (ankyrin repeat domain 13A) Using a linear mixed model, differential expression with age was identified in ANKRD13A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKRD13D (ankyrin repeat domain 13 family, member D) Using a linear mixed model, differential expression with age was identified in ANKRD13D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ankrd26 (ankyrin repeat domain 26)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ANKRD35 (ankyrin repeat domain 35) Using a linear mixed model, differential expression with age was identified in ANKRD35 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKRD39 (ankyrin repeat domain 39) Using a linear mixed model, differential expression with age was identified in ANKRD39 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) Using a linear mixed model, differential expression with age was identified in ANKS1A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANKZF1 (ankyrin repeat and zinc finger domain containing 1) Using a linear mixed model, differential expression with age was identified in ANKZF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANO10 (anoctamin 10) Using a linear mixed model, differential expression with age was identified in ANO10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ANP32B (acidic (leucine-rich) nuclear phosphoprotein 32 family, member B)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Antxr2 (anthrax toxin receptor 2)   Male and Female 3 23 Hematological System -15.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Anxa2 (annexin A2)   Male and Female 2 15 Hippocampus 8.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
Anxa3 (annexin A3)   Male and Female 5 25 Skeletal Muscle 23.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
ANXA4 (annexin A4)   Male and Female 26 106 Brain 11.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
AP1G2 (adaptor-related protein complex 1, gamma 2 subunit) Using a linear mixed model, differential expression with age was identified in AP1G2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)   Male and Female 26 106 Brain -12.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
AP1S2 (adaptor-related protein complex 1, sigma 2 subunit) Using a linear mixed model, differential expression with age was identified in AP1S2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ap2m1 (adaptor protein complex AP-2, mu1)   Male and Female 6 22 Liver 1.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
AP2S1 (adaptor-related protein complex 2, sigma 1 subunit) Using a linear mixed model, differential expression with age was identified in AP2S1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AP4B1 (adaptor-related protein complex 4, beta 1 subunit) Using a linear mixed model, differential expression with age was identified in AP4B1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AP5S1 (adaptor-related protein complex 5, sigma 1 subunit) Using a linear mixed model, differential expression with age was identified in AP5S1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APAF1 (apoptotic peptidase activating factor 1) Using a linear mixed model, differential expression with age was identified in APAF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APBB1IP (amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein)   Male and Female 27 92 Kidney 23.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
APBB3 (amyloid beta (A4) precursor protein-binding, family B, member 3) Using a linear mixed model, differential expression with age was identified in APBB3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APCDD1L (adenomatosis polyposis coli down-regulated 1-like) Using a linear mixed model, differential expression with age was identified in APCDD1L in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APEH (acylaminoacyl-peptide hydrolase) Using a linear mixed model, differential expression with age was identified in APEH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APEH (acylaminoacyl-peptide hydrolase) Using a linear mixed model, differential expression with age was identified in APEH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APH1B (APH1B gamma secretase subunit) Using a linear mixed model, differential expression with age was identified in APH1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Apln (apelin)   Male and Female 3 23 Hematological System 13.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
APMAP (adipocyte plasma membrane associated protein) Using a linear mixed model, differential expression with age was identified in APMAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APOA1BP (apolipoprotein A-I binding protein) Using a linear mixed model, differential expression with age was identified in APOA1BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Apobec1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1)   Male and Female 5 22 Brain 92.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
Apod (apolipoprotein D)   Male and Female 5 30 Anatomical System 14.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
APOD (apolipoprotein D)   Male and Female 26 106 Brain 14.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
APOE (apolipoprotein E) Methylation level of APOE in individuals 30 years of age apart decreased by 10.6% in the brain. Male and Female 63 92 Prefrontal Cortex     2707: Wang et al. (2008) "Age-specific epigenetic drift in late-onset Alzheimer's disease." PLoS ONE 3(7):e2698 (18628954)
APOLD1 (apolipoprotein L domain containing 1) Using a linear mixed model, differential expression with age was identified in APOLD1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APOO (apolipoprotein O)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)
APPL1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
APRT (adenine phosphoribosyltransferase) Using a linear mixed model, differential expression with age was identified in APRT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
APRT (adenine phosphoribosyltransferase) Using a linear mixed model, differential expression with age was identified in APRT in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARG2 (arginase 2) Using a linear mixed model, differential expression with age was identified in ARG2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARGLU1 (arginine and glutamate rich 1) Using a linear mixed model, differential expression with age was identified in ARGLU1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARHGAP15 (Rho GTPase activating protein 15) Using a linear mixed model, differential expression with age was identified in ARHGAP15 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Arhgap18 (Rho GTPase activating protein 18)   Male and Female 2 26 Lung 5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Arhgap26 (Rho GTPase activating protein 26)   Male and Female 2 26 Lung 2.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ARHGAP33 (Rho GTPase activating protein 33) Using a linear mixed model, differential expression with age was identified in ARHGAP33 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARHGAP33 (Rho GTPase activating protein 33) Using a linear mixed model, differential expression with age was identified in ARHGAP33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Arhgdia (Rho GDP dissociation inhibitor (GDI) alpha)   Male and Female 6 22 Liver 9.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
ARHGEF10 (Rho guanine nucleotide exchange factor (GEF) 10) Using a linear mixed model, differential expression with age was identified in ARHGEF10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARHGEF37 (Rho guanine nucleotide exchange factor (GEF) 37) Using a linear mixed model, differential expression with age was identified in ARHGEF37 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARHGEF4 (Rho guanine nucleotide exchange factor (GEF) 4) Using a linear mixed model, differential expression with age was identified in ARHGEF4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARID1A (AT rich interactive domain 1A (SWI-like)) Gene expression showed a significant (p<E-3) increase in the expression of ARID1A in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 51.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ARID1A (AT rich interactive domain 1A (SWI-like)) Gene expression showed a significant (p<E-3) increase in the expression of ARID1A in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 103.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ARID4B (AT rich interactive domain 4B (RBP1-like)) Using a linear mixed model, differential expression with age was identified in ARID4B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) Using a linear mixed model, differential expression with age was identified in ARIH2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Arl1 (ADP-ribosylation factor-like 1)   Male and Female 5 25 Skeletal Muscle 6.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
ARL4A (ADP-ribosylation factor-like 4A) Using a linear mixed model, differential expression with age was identified in ARL4A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARL4A (ADP-ribosylation factor-like 4A) Using a linear mixed model, differential expression with age was identified in ARL4A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Arl5a (ADP-ribosylation factor-like 5A)   Male and Female 8 24 Muscle 3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ARL6IP6 (ADP-ribosylation-like factor 6 interacting protein 6) Gene expression showed a significant (p<E-3) decrease in the expression of ARL6IP6 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -76.13 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
ARMC6 (armadillo repeat containing 6) Using a linear mixed model, differential expression with age was identified in ARMC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Armcx1 (armadillo repeat containing, X-linked 1)   Male and Female 2 26 Lung -6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ARNTL (aryl hydrocarbon receptor nuclear translocator-like) Using a linear mixed model, differential expression with age was identified in ARNTL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARPC2 (actin related protein 2/3 complex, subunit 2, 34kDa) Using a linear mixed model, differential expression with age was identified in ARPC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARPC5L (actin related protein 2/3 complex, subunit 5-like)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ARPIN (actin-related protein 2/3 complex inhibitor) Using a linear mixed model, differential expression with age was identified in C15orf38 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARRDC4 (arrestin domain containing 4) Using a linear mixed model, differential expression with age was identified in ARRDC4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARSA (arylsulfatase A)   Male and Female 26 106 Brain 17.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ARSF (arylsulfatase F) Using a linear mixed model, differential expression with age was identified in ARSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ARSG (arylsulfatase G) Comparison of DNA methylation showed a significantly increased methylation level of ARSG in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis 19.6 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2) Using a linear mixed model, differential expression with age was identified in ASAP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASB13 (ankyrin repeat and SOCS box containing 13) Using a linear mixed model, differential expression with age was identified in ASB13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASCL2 (achaete-scute family bHLH transcription factor 2) Using a linear mixed model, differential expression with age was identified in ASCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASIC2 (acid-sensing (proton-gated) ion channel 2) Using a linear mixed model, differential expression with age was identified in ASIC2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ASNS (asparagine synthetase (glutamine-hydrolyzing)) Using a linear mixed model, differential expression with age was identified in ASNS in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASPA (aspartoacylase) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of ASPA and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
ASPM (asp (abnormal spindle) homolog, microcephaly associated (Drosophila)) Using a linear mixed model, differential expression with age was identified in ASPM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ASUN (asunder spermatogenesis regulator) Using a linear mixed model, differential expression with age was identified in ASUN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATF6 (activating transcription factor 6) Using a linear mixed model, differential expression with age was identified in ATF6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATF6 (activating transcription factor 6) Using a linear mixed model, differential expression with age was identified in ATF6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Atg12 (autophagy-related 12 (yeast))   Male and Female 8 24 Muscle -5.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ATG16L2 (autophagy related 16-like 2 (S. cerevisiae)) Using a linear mixed model, differential expression with age was identified in ATG16L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATG4A (autophagy related 4A, cysteine peptidase) Using a linear mixed model, differential expression with age was identified in ATG4A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Atg5 (autophagy-related 5 (yeast))   Male and Female 6 22 Liver -7.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
Atg9b (ATG9 autophagy related 9 homolog B (S. cerevisiae))   Male and Female 3 23 Hematological System 7.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
ATL3 (atlastin GTPase 3) Using a linear mixed model, differential expression with age was identified in ATL3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATOX1 (antioxidant 1 copper chaperone) Using a linear mixed model, differential expression with age was identified in ATOX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Atp1b2 (ATPase, Na+/K+ transporting, beta 2 polypeptide)   Male and Female 5 30 Anatomical System 4.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP2B2 (ATPase, Ca++ transporting, plasma membrane 2)   Male and Female 26 106 Brain -23.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP5A1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle)   Male and Female 26 106 Brain -17.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP5B (ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide)   Male and Female 26 106 Brain -9.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP5C1 (ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ATP5D (ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit) Using a linear mixed model, differential expression with age was identified in ATP5D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP5G1 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9))   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ATP5G3 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9))   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Atp5j2 (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2)   Male and Female 8 24 Muscle -2.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Atp5l (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g)   Male and Female 8 24 Muscle -1.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
ATP5O (ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ATP5SL (ATP5S-like) Using a linear mixed model, differential expression with age was identified in ATP5SL in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V0A4 (ATPase, H+ transporting, lysosomal V0 subunit a4) Using a linear mixed model, differential expression with age was identified in ATP6V0A4 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V0B (ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b) Using a linear mixed model, differential expression with age was identified in ATP6V0B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V0C (ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c) Using a linear mixed model, differential expression with age was identified in ATP6V0C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1)   Male and Female 26 106 Brain -8.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP6V0D1 (ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1) Using a linear mixed model, differential expression with age was identified in ATP6V0D1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V0E1 (ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1) Using a linear mixed model, differential expression with age was identified in ATP6V0E1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V1A (ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A)   Male and Female 26 106 Brain -7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
ATP6V1C1 (ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1) Using a linear mixed model, differential expression with age was identified in ATP6V1C1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V1D (ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D) Using a linear mixed model, differential expression with age was identified in ATP6V1D in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2)   Male and Female 26 106 Brain -7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Atp7a (ATPase, Cu++ transporting, alpha polypeptide)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
ATPAF1 (ATP synthase mitochondrial F1 complex assembly factor 1)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
ATPIF1 (ATPase inhibitory factor 1) Using a linear mixed model, differential expression with age was identified in ATPIF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
ATXN1 (ataxin 1)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Atxn2 (ataxin 2)   Male and Female 2 26 Lung -3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
AU020206 (expressed sequence AU020206)   Male and Female 2 15 Hippocampus 10.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
Aurkc (aurora kinase C)   Male and Female 5 22 Brain -65.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
AUTS2 (autism susceptibility candidate 2) Using a linear mixed model, differential expression with age was identified in AUTS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AUTS2 (autism susceptibility candidate 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypermethylation of AUTS2 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
Avpi1 (arginine vasopressin-induced 1)   Male and Female 3 23 Hematological System 15.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
AWAT1 (acyl-CoA wax alcohol acyltransferase 1) Using a linear mixed model, differential expression with age was identified in AWAT1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AWAT2 (acyl-CoA wax alcohol acyltransferase 2) Using a linear mixed model, differential expression with age was identified in AWAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AXDND1 (axonemal dynein light chain domain containing 1) Using a linear mixed model, differential expression with age was identified in AXDND1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
AZIN1 (antizyme inhibitor 1)   Male and Female 26 106 Brain -11.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
B230312A22Rik (RIKEN cDNA B230312A22 gene)   Male and Female 8 24 Muscle 4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
B2m (beta-2 microglobulin)   Male and Female 2 15 Hippocampus 6.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group))   Male and Female 26 106 Brain -22.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
B3galt1 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1)   Male and Female 3 23 Hematological System 36.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)   Male and Female 0 102 Pons 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)   Male and Female 0 102 Frontal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)   Male and Female 0 102 Temporal Lobe 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)   Male and Female 0 102 Cerebellum 0.0 <0.001 2842: Hernandez et al. (2011) "Distinct DNA methylation changes highly correlated with chronological age in the human brain." Hum. Mol. Genet. 20(6):1164-1172 (21216877)
B4galnt4 (beta-1,4-N-acetyl-galactosaminyl transferase 4)   Male and Female 3 23 Hematological System 11.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
BAG2 (BCL2-associated athanogene 2)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
BATF3 (basic leucine zipper transcription factor, ATF-like 3) Using a linear mixed model, differential expression with age was identified in BATF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BAZ1A (bromodomain adjacent to zinc finger domain, 1A) Using a linear mixed model, differential expression with age was identified in BAZ1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BAZ2B (bromodomain adjacent to zinc finger domain, 2B) Using a linear mixed model, differential expression with age was identified in BAZ2B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BBOX1 (butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1) Using a linear mixed model, differential expression with age was identified in BBOX1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BBS2 (Bardet-Biedl syndrome 2) Using a linear mixed model, differential expression with age was identified in BBS2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BBS4 (Bardet-Biedl syndrome 4) Using a linear mixed model, differential expression with age was identified in BBS4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BC017643 (cDNA sequence BC017643)   Male and Female 3 23 Hematological System -9.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
BC026782 (cDNA sequence BC026782)   Male and Female 5 22 Brain 217.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
BC037703 (cDNA sequence BC037703)   Male and Female 5 22 Brain 809.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
BC048546 (cDNA sequence BC048546)   Male and Female 2 26 Lung 18.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
BCAN (brevican) Using a linear mixed model, differential expression with age was identified in BCAN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCAP29 (B-cell receptor-associated protein 29) Using a linear mixed model, differential expression with age was identified in BCAP29 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Bcap31 (B-cell receptor-associated protein 31)   Male and Female 5 25 Skeletal Muscle 4.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
BCAS3 (breast carcinoma amplified sequence 3) Using a linear mixed model, differential expression with age was identified in BCAS3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCAT2 (branched chain amino-acid transaminase 2, mitochondrial) Using a linear mixed model, differential expression with age was identified in BCAT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCKDHB (branched chain keto acid dehydrogenase E1, beta polypeptide) Using a linear mixed model, differential expression with age was identified in BCKDHB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCKDK (branched chain ketoacid dehydrogenase kinase) Using a linear mixed model, differential expression with age was identified in BCKDK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCL11A (B-cell CLL/lymphoma 11A (zinc finger protein))   Male and Female 26 106 Brain -14.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
BCL11A (B-cell CLL/lymphoma 11A (zinc finger protein)) Using a linear mixed model, differential expression with age was identified in BCL11A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Bcl3 (B-cell leukemia/lymphoma 3)   Male and Female 3 23 Hematological System 25.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
BCL6 (B-cell CLL/lymphoma 6) Using a linear mixed model, differential expression with age was identified in BCL6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCL6 (B-cell CLL/lymphoma 6) Using a linear mixed model, differential expression with age was identified in BCL6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BCO1 (beta-carotene oxygenase 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BCMO1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
BCS1L (BCS1-like (yeast))   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
BDH1 (3-hydroxybutyrate dehydrogenase, type 1) Using a linear mixed model, differential expression with age was identified in BDH1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Bdnf (brain derived neurotrophic factor)   Male and Female 5 25 Skeletal Muscle 5.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
Bdp1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
BEX1 (brain expressed, X-linked 1) Using a linear mixed model, differential expression with age was identified in BEX1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BHLHE22 (basic helix-loop-helix family, member e22) Using a linear mixed model, differential expression with age was identified in BHLHE22 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BHLHE40 (basic helix-loop-helix family, member e40) Using a linear mixed model, differential expression with age was identified in BHLHE40 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BICC1 (BicC family RNA binding protein 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of BICC1 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
BID (BH3 interacting domain death agonist) Using a linear mixed model, differential expression with age was identified in BID in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BIRC6 (baculoviral IAP repeat containing 6) Using a linear mixed model, differential expression with age was identified in BIRC6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Birc6 (baculoviral IAP repeat-containing 6)   Male and Female 2 15 Hippocampus 2.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
BLCAP (bladder cancer associated protein) Using a linear mixed model, differential expression with age was identified in BLCAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BLOC1S2 (biogenesis of lysosomal organelles complex-1, subunit 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BLOC1S2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
BMP6 (bone morphogenetic protein 6) Using a linear mixed model, differential expression with age was identified in BMP6 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BMP7 (bone morphogenetic protein 7)   Male and Female 26 106 Brain 20.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
BMPR1B (bone morphogenetic protein receptor, type IB)   Male and Female 22 73 Skeletal Muscle -11.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
BMS1 (BMS1 ribosome biogenesis factor) Using a linear mixed model, differential expression with age was identified in BMS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BMX (BMX non-receptor tyrosine kinase) Using a linear mixed model, differential expression with age was identified in BMX in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BOC (BOC cell adhesion associated, oncogene regulated) Using a linear mixed model, differential expression with age was identified in BOC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BOK (BCL2-related ovarian killer) Using a linear mixed model, differential expression with age was identified in BOK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BOLA3 (bolA homolog 3 (E. coli))   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Bptf (bromodomain PHD finger transcription factor)   Male and Female 8 24 Muscle 3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
BRD8 (bromodomain containing 8) Using a linear mixed model, differential expression with age was identified in BRD8 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BRE (brain and reproductive organ-expressed (TNFRSF1A modulator)) Using a linear mixed model, differential expression with age was identified in BRE in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BRI3BP (BRI3 binding protein) Using a linear mixed model, differential expression with age was identified in BRI3BP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Brms1l (breast cancer metastasis-suppressor 1-like)   Male and Female 2 26 Lung -1.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
BRP44L (brain protein 44-like)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
BRP44L (brain protein 44-like)   Male and Female 27 92 Kidney -9.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)) Using a linear mixed model, differential expression with age was identified in BSCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BSG (basigin (Ok blood group)) Using a linear mixed model, differential expression with age was identified in BSG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BST2 (bone marrow stromal cell antigen 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BST2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
BTBD11 (BTB (POZ) domain containing 11) Using a linear mixed model, differential expression with age was identified in BTBD11 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BTBD2 (BTB (POZ) domain containing 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of BTBD2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
BTBD3 (BTB (POZ) domain containing 3) Using a linear mixed model, differential expression with age was identified in BTBD3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BTBD6 (BTB (POZ) domain containing 6) Using a linear mixed model, differential expression with age was identified in BTBD6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BTD (biotinidase) Using a linear mixed model, differential expression with age was identified in BTD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BTN2A1 (butyrophilin, subfamily 2, member A1) Using a linear mixed model, differential expression with age was identified in BTN2A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
BTNL3 (butyrophilin-like 3)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
BUD31 (BUD31 homolog (S. cerevisiae)) Using a linear mixed model, differential expression with age was identified in BUD31 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C10orf35 (chromosome 10 open reading frame 35) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C10orf35 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
C10orf82 (chromosome 10 open reading frame 82) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of C10orf82 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
C11orf45 (chromosome 11 open reading frame 45) Using a linear mixed model, differential expression with age was identified in C11orf45 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C11orf70 (chromosome 11 open reading frame 70) Using a linear mixed model, differential expression with age was identified in C11orf70 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C11orf73 (chromosome 11 open reading frame 73)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C11orf74 (chromosome 11 open reading frame 74) Using a linear mixed model, differential expression with age was identified in C11orf74 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C12orf65 (chromosome 12 open reading frame 65) Using a linear mixed model, differential expression with age was identified in C12orf65 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C130026I21Rik (RIKEN cDNA C130026I21 gene)   Male and Female 2 26 Lung 27.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
C130026I21Rik (RIKEN cDNA C130026I21 gene)   Male and Female 3 23 Hematological System 22.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
C14orf132 (chromosome 14 open reading frame 132) Using a linear mixed model, differential expression with age was identified in C14orf132 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C14orf177 (chromosome 14 open reading frame 177) Comparison of DNA methylation showed a significantly decreased methylation level of C14orf177 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -16.2 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
C14orf177 (chromosome 14 open reading frame 177) Comparison of DNA methylation showed a significantly increased methylation level of C14orf177 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell 42.5 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
C14orf2 (chromosome 14 open reading frame 2)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C14orf2 (chromosome 14 open reading frame 2) Using a linear mixed model, differential expression with age was identified in C14orf2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C14orf28 (chromosome 14 open reading frame 28) Using a linear mixed model, differential expression with age was identified in C14orf28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C15orf27 (chromosome 15 open reading frame 27) Using a linear mixed model, differential expression with age was identified in C15orf27 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C15orf59 (chromosome 15 open reading frame 59) Using a linear mixed model, differential expression with age was identified in C15orf59 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C16orf61 (chromosome 16 open reading frame 61)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C17orf49 (chromosome 17 open reading frame 49) Using a linear mixed model, differential expression with age was identified in C17orf49 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C18orf19 (chromosome 18 open reading frame 19)   Male and Female 20 75 Skeletal Muscle -5.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C19orf10 (chromosome 19 open reading frame 10) Using a linear mixed model, differential expression with age was identified in C19orf10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C19orf24 (chromosome 19 open reading frame 24) Using a linear mixed model, differential expression with age was identified in C19orf24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1orf122 (chromosome 1 open reading frame 122) Using a linear mixed model, differential expression with age was identified in C1orf122 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1orf158 (chromosome 1 open reading frame 158) Using a linear mixed model, differential expression with age was identified in C1orf158 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1orf162 (chromosome 1 open reading frame 162)   Male and Female 27 92 Kidney 37.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
C1orf21 (chromosome 1 open reading frame 21) Using a linear mixed model, differential expression with age was identified in C1orf21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1orf64 (chromosome 1 open reading frame 64) Using a linear mixed model, differential expression with age was identified in C1orf64 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1orf95 (chromosome 1 open reading frame 95)   Male and Female 26 106 Brain -5.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
C1QA (complement component 1, q subcomponent, A chain) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 243.36 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QA (complement component 1, q subcomponent, A chain) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 154.93 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QA (complement component 1, q subcomponent, A chain) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QA from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 98.36 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QA (complement component 1, q subcomponent, A chain) Using a linear mixed model, differential expression with age was identified in C1QA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1qa (complement component 1, q subcomponent, alpha polypeptide)   Male and Female 5 30 Anatomical System 5.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
C1QB (complement component 1, q subcomponent, B chain) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 186.74 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QB (complement component 1, q subcomponent, B chain) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 391.36 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QB (complement component 1, q subcomponent, B chain) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 288.08 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QB (complement component 1, q subcomponent, B chain) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QB from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 166.75 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QB (complement component 1, q subcomponent, B chain) Using a linear mixed model, differential expression with age was identified in C1QB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1qb (complement component 1, q subcomponent, beta polypeptide)   Male and Female 2 15 Hippocampus 3.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
C1QC (complement component 1, q subcomponent, C chain)   Male and Female 27 92 Kidney 27.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
C1qc (complement component 1, q subcomponent, C chain)   Male and Female 5 30 Anatomical System 5.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
C1qc (complement component 1, q subcomponent, C chain)   Male and Female 2 15 Hippocampus 2.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
C1QC (complement component 1, q subcomponent, C chain) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 154.27 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QC (complement component 1, q subcomponent, C chain) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 323.41 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QC (complement component 1, q subcomponent, C chain) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 216.18 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QC (complement component 1, q subcomponent, C chain) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1QC from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 126.06 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1QC (complement component 1, q subcomponent, C chain) Using a linear mixed model, differential expression with age was identified in C1QC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1QTNF1 (C1q and tumor necrosis factor related protein 1) Using a linear mixed model, differential expression with age was identified in C1QTNF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1qtnf2 (C1q and tumor necrosis factor related protein 2)   Male and Female 2 26 Lung -8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
C1qtnf3 (C1q and tumor necrosis factor related protein 3)   Male and Female 2 26 Lung -22.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
C1QTNF5 (C1q and tumor necrosis factor related protein 5) Using a linear mixed model, differential expression with age was identified in C1QTNF5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1QTNF6 (C1q and tumor necrosis factor related protein 6) Using a linear mixed model, differential expression with age was identified in C1QTNF6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C1R (complement component 1, r subcomponent)   Male and Female 20 75 Skeletal Muscle 8.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C1R (complement component 1, r subcomponent)   Male and Female 27 92 Kidney 21.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
C1S (complement component 1, s subcomponent)   Male and Female 27 92 Kidney 24.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
C1S (complement component 1, s subcomponent)   Male and Female 20 75 Skeletal Muscle 7.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C1S (complement component 1, s subcomponent) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 152.93 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1S (complement component 1, s subcomponent) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 105.32 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1S (complement component 1, s subcomponent) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 54.03 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1S (complement component 1, s subcomponent) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 60.37 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C1S (complement component 1, s subcomponent) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C1S from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 71.93 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C20orf24 (chromosome 20 open reading frame 24) Using a linear mixed model, differential expression with age was identified in C20orf24 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C21orf33 (chromosome 21 open reading frame 33) Using a linear mixed model, differential expression with age was identified in C21orf33 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C2orf88 (chromosome 2 open reading frame 88)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C3 (complement component 3)   Male and Female 6 22 Liver 5.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
C3 (complement component 3)   Male and Female 20 75 Skeletal Muscle 16.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C3 (complement component 3) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 201.58 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C3 (complement component 3) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C3 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 108.42 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C3AR1 (complement component 3a receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 196.97 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C3AR1 (complement component 3a receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 134.8 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C3AR1 (complement component 3a receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C3AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 89.04 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C3orf18 (chromosome 3 open reading frame 18) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C3orf18 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
C4A (complement component 4A (Rodgers blood group)) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 115.31 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4A (complement component 4A (Rodgers blood group)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 226.29 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4A (complement component 4A (Rodgers blood group)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 216.42 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4A (complement component 4A (Rodgers blood group)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 153.8 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4A (complement component 4A (Rodgers blood group)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C4A from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 187.29 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4a (complement component 4A (Rodgers blood group))   Male and Female 5 30 Anatomical System 26.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
C4B (complement component 4B (Chido blood group)) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 289.92 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4B (complement component 4B (Chido blood group)) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 466.15 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4B (complement component 4B (Chido blood group)) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 444.8 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4B (complement component 4B (Chido blood group)) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C4B from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 895.88 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C4orf17 (chromosome 4 open reading frame 17)   Male and Female 20 75 Skeletal Muscle -13.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C5 (complement component 5) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 35.31 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C5 (complement component 5) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe C5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 43.68 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C5AR1 (complement component 5a receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus C5AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 166.23 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C5AR1 (complement component 5a receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe C5AR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 34.3 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
C5orf13 (chromosome 5 open reading frame 13)   Male and Female 26 106 Brain -8.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
C5orf30 (chromosome 5 open reading frame 30)   Male and Female 26 106 Brain -19.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
C6orf106 (chromosome 6 open reading frame 106)   Male and Female 26 106 Brain -12.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
C6orf106 (chromosome 6 open reading frame 106) Using a linear mixed model, differential expression with age was identified in C6orf106 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C6orf136 (chromosome 6 open reading frame 136)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C6orf52 (chromosome 6 open reading frame 52) Using a linear mixed model, differential expression with age was identified in C6orf52 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C78197 (expressed sequence C78197)   Male and Female 5 25 Skeletal Muscle 16.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
C78339 (expressed sequence C78339)   Male and Female 8 24 Muscle 4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
C7orf44 (chromosome 7 open reading frame 44)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C8orf44 (chromosome 8 open reading frame 44) Using a linear mixed model, differential expression with age was identified in C8orf44 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
C9orf123 (chromosome 9 open reading frame 123)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
C9orf139 (chromosome 9 open reading frame 139) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of C9orf139 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
C9orf16 (chromosome 9 open reading frame 16) Using a linear mixed model, differential expression with age was identified in C9orf16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CA11 (carbonic anhydrase XI)   Male and Female 26 106 Brain -6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CA12 (carbonic anhydrase XII) Using a linear mixed model, differential expression with age was identified in CA12 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CA12 (carbonic anhydrase XII) Using a linear mixed model, differential expression with age was identified in CA12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CA14 (carbonic anhydrase XIV) Using a linear mixed model, differential expression with age was identified in CA14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CA4 (carbonic anhydrase IV)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CA9 (carbonic anhydrase IX) Using a linear mixed model, differential expression with age was identified in CA9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CACFD1 (calcium channel flower domain containing 1) Using a linear mixed model, differential expression with age was identified in CACFD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit) Using a linear mixed model, differential expression with age was identified in CACNA1F in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CACNB2 (calcium channel, voltage-dependent, beta 2 subunit)   Male and Female 26 106 Brain -8.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CADM2 (cell adhesion molecule 2) Using a linear mixed model, differential expression with age was identified in CADM2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CADM3 (cell adhesion molecule 3) Using a linear mixed model, differential expression with age was identified in CADM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALB1 (calbindin 1, 28kDa)   Male and Female 26 106 Brain -58.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CALD1 (caldesmon 1) Using a linear mixed model, differential expression with age was identified in CALD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALM1 (calmodulin 1 (phosphorylase kinase, delta))   Male and Female 26 106 Brain -5.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CALM3 (calmodulin 3 (phosphorylase kinase, delta))   Male and Female 26 106 Brain -10.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CALML3 (calmodulin-like 3) Using a linear mixed model, differential expression with age was identified in CALML3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALML4 (calmodulin-like 4) Using a linear mixed model, differential expression with age was identified in CALML4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALR (calreticulin) Using a linear mixed model, differential expression with age was identified in CALR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALU (calumenin) Using a linear mixed model, differential expression with age was identified in CALU in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CALY (calcyon neuron-specific vesicular protein) Using a linear mixed model, differential expression with age was identified in CALY in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Camk1d (calcium/calmodulin-dependent protein kinase ID)   Male and Female 2 26 Lung 6.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Camk2b (calcium/calmodulin-dependent protein kinase II, beta)   Male and Female 8 24 Muscle 7.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CAMK2G (calcium/calmodulin-dependent protein kinase II gamma) Using a linear mixed model, differential expression with age was identified in CAMK2G in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CAMK4 (calcium/calmodulin-dependent protein kinase IV)   Male and Female 26 106 Brain -17.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, beta)   Male and Female 26 106 Brain -7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CANX (calnexin) Using a linear mixed model, differential expression with age was identified in CANX in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CAPG (capping protein (actin filament), gelsolin-like) Comparison of DNA methylation showed a significantly decreased methylation level of CAPG in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -20.1 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CAPG (capping protein (actin filament), gelsolin-like) Comparison of DNA methylation showed a significantly decreased methylation level of CAPG in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -19.3 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CAPN13 (calpain 13) Using a linear mixed model, differential expression with age was identified in CAPN13 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CAPNS1 (calpain, small subunit 1) Using a linear mixed model, differential expression with age was identified in CAPNS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CAPRIN2 (caprin family member 2) Using a linear mixed model, differential expression with age was identified in CAPRIN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CAPS (calcyphosine) Comparison of DNA methylation showed a significantly decreased methylation level of CAPS in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -28.0 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CAPS (calcyphosine) Comparison of DNA methylation showed a significantly decreased methylation level of CAPS in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -17.3 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
Car2 (carbonic anhydrase 2)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Card10 (caspase recruitment domain family, member 10)   Male and Female 3 23 Hematological System 19.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CARHSP1 (calcium regulated heat stable protein 1, 24kDa) Using a linear mixed model, differential expression with age was identified in CARHSP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CASC1 (cancer susceptibility candidate 1) Using a linear mixed model, differential expression with age was identified in CASC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 30.21 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 165.49 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 101.82 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 102.73 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 91.77 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 137.32 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 41.97 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 40.31 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 28.41 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 43.44 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASP1 (caspase 1, apoptosis-related cysteine peptidase) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CASP1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 53.3 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CASQ2 (calsequestrin 2 (cardiac muscle)) Using a linear mixed model, differential expression with age was identified in CASQ2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Catsper1 (cation channel, sperm associated 1)   Male and Female 8 24 Muscle -10.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CATSPERG (catsper channel auxiliary subunit gamma) Using a linear mixed model, differential expression with age was identified in CATSPERG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cav1 (caveolin 1, caveolae protein)   Male and Female 5 22 Brain 6.0 <0.001 2765: Godbout et al. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system." FASEB J. 19(10):1329-1331 (15919760)|2833: NCBI GEO Dataset (2005) "Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS1311)
CBS (cystathionine-beta-synthase)   Male and Female 26 106 Brain 18.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CBX7 (chromobox homolog 7)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CBX7 (chromobox homolog 7) Using a linear mixed model, differential expression with age was identified in CBX7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CBX7 (chromobox homolog 7) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CBX7 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Ccbe1 (collagen and calcium binding EGF domains 1)   Male and Female 3 23 Hematological System 57.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CCBL1 (cysteine conjugate-beta lyase, cytoplasmic) Using a linear mixed model, differential expression with age was identified in CCBL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC105 (coiled-coil domain containing 105) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CCDC105 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CCDC130 (coiled-coil domain containing 130) Using a linear mixed model, differential expression with age was identified in CCDC130 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC14 (coiled-coil domain containing 14) Using a linear mixed model, differential expression with age was identified in CCDC14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC146 (coiled-coil domain containing 146) Using a linear mixed model, differential expression with age was identified in CCDC146 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC167 (coiled-coil domain containing 167) Using a linear mixed model, differential expression with age was identified in CCDC167 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC174 (coiled-coil domain containing 174) Using a linear mixed model, differential expression with age was identified in CCDC174 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC3 (coiled-coil domain containing 3)   Male and Female 27 92 Kidney 19.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
CCDC3 (coiled-coil domain containing 3) Using a linear mixed model, differential expression with age was identified in CCDC3 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC46 (coiled-coil domain containing 46)   Male and Female 26 106 Brain 86.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CCDC72 (coiled-coil domain containing 72)   Male and Female 20 75 Skeletal Muscle 2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CCDC85A (coiled-coil domain containing 85A) Using a linear mixed model, differential expression with age was identified in CCDC85A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCDC86 (coiled-coil domain containing 86) Using a linear mixed model, differential expression with age was identified in CCDC86 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCK (cholecystokinin)   Male and Female 26 106 Brain -6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CCKBR (cholecystokinin B receptor)   Male and Female 26 106 Brain -11.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CCL2 (chemokine (C-C motif) ligand 2) Using a linear mixed model, differential expression with age was identified in CCL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCL21 (chemokine (C-C motif) ligand 21) Using a linear mixed model, differential expression with age was identified in CCL21 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ccl21b (chemokine (C-C motif) ligand 21B)   Male and Female 5 30 Anatomical System 51.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
CCL23 (chemokine (C-C motif) ligand 23) Using a linear mixed model, differential expression with age was identified in CCL23 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCL28 (chemokine (C-C motif) ligand 28) Using a linear mixed model, differential expression with age was identified in CCL28 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ccnf (cyclin F)   Male and Female 6 22 Liver -3.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CCNF (cyclin F) Using a linear mixed model, differential expression with age was identified in CCNF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CCR1 (chemokine (C-C motif) receptor 1) Comparison of DNA methylation showed a significantly decreased methylation level of CCR1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -16.5 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CCR1 (chemokine (C-C motif) receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 93.8 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CCR1 (chemokine (C-C motif) receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 53.94 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CCR1 (chemokine (C-C motif) receptor 1) Comparison of DNA methylation showed a significantly increased methylation level of CCR1 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell 31.2 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CCR1 (chemokine (C-C motif) receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 182.46 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CCR1 (chemokine (C-C motif) receptor 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CCR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 129.18 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CCRN4L (CCR4 carbon catabolite repression 4-like (S. cerevisiae)) Using a linear mixed model, differential expression with age was identified in CCRN4L in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cct5 (chaperonin containing Tcp1, subunit 5 (epsilon))   Male and Female 6 22 Liver 7.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CD14 (CD14 molecule) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 154.26 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD14 (CD14 molecule) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 395.01 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD14 (CD14 molecule) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 186.54 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD14 (CD14 molecule) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD14 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 134.89 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD14 (CD14 molecule) Using a linear mixed model, differential expression with age was identified in CD14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cd160 (CD160 antigen)   Male and Female 8 24 Muscle -6.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Cd163 (CD163 antigen)   Male and Female 2 26 Lung 28.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 515.74 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 552.3 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 488.09 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 491.51 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 283.01 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163 (CD163 molecule) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CD163 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 383.1 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CD163L1 (CD163 molecule-like 1) Using a linear mixed model, differential expression with age was identified in CD163L1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD164L2 (CD164 sialomucin-like 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CD164L2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CD1B (CD1b molecule) Using a linear mixed model, differential expression with age was identified in CD1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD1C (CD1c molecule) Using a linear mixed model, differential expression with age was identified in CD1C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD207 (CD207 molecule, langerin)   Male and Female 20 75 Skeletal Muscle -7.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CD209 (CD209 molecule) Using a linear mixed model, differential expression with age was identified in CD209 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD274 (CD274 molecule) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CD274 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Cd28 (CD28 antigen)   Male and Female 2 26 Lung 17.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CD2BP2 (CD2 (cytoplasmic tail) binding protein 2) Using a linear mixed model, differential expression with age was identified in CD2BP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD300A (CD300a molecule) Using a linear mixed model, differential expression with age was identified in CD300A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CD34 (CD34 molecule) Comparison of DNA methylation showed a significantly decreased methylation level of CD34 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -16.6 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CD34 (CD34 molecule) Comparison of DNA methylation showed a significantly decreased methylation level of CD34 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -17.3 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
Cd38 (CD38 antigen)   Male and Female 4 15 Cochlea 26.0 <0.001 2666: Someya et al. (2007) "Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis." Neurobiol. Aging 28(10):1613-1622 (16890326)
CD4 (CD4 molecule) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 718 Sweden subjects within the age range of 25 to 92 years, showed a possitive correlation between hypomethylation of CD4 and age. Male and Female 25 92 Blood     3455: McClay, JL et al. (2014) "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects." Hum. Mol. Genet. 23(5):1175-1185 (24135035)
CD79B (CD79b molecule, immunoglobulin-associated beta) Using a linear mixed model, differential expression with age was identified in CD79B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cd8b1 (CD8 antigen, beta chain 1)   Male and Female 2 26 Lung 36.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CDA (cytidine deaminase) Using a linear mixed model, differential expression with age was identified in CDA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDC16 (cell division cycle 16) Using a linear mixed model, differential expression with age was identified in CDC16 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDC25C (cell division cycle 25C) Using a linear mixed model, differential expression with age was identified in CDC25C in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDC2L2 (cell division cycle 2-like 2 (PITSLRE proteins))   Male and Female 26 106 Brain 27.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CDC42EP3 (CDC42 effector protein (Rho GTPase binding) 3)   Male and Female 20 75 Skeletal Muscle 6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CDCP1 (CUB domain containing protein 1) Using a linear mixed model, differential expression with age was identified in CDCP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDH12 (cadherin 12, type 2 (N-cadherin 2)) Using a linear mixed model, differential expression with age was identified in CDH12 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDH5 (cadherin 5, type 2 (vascular endothelium))   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Cdh6 (cadherin 6)   Male and Female 2 15 Hippocampus -9.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
CDHR1 (cadherin-related family member 1) Using a linear mixed model, differential expression with age was identified in CDHR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDK12 (cyclin-dependent kinase 12)   Male and Female 26 106 Brain 17.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CDK14 (cyclin-dependent kinase 14) Using a linear mixed model, differential expression with age was identified in CDK14 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cdk18 (cyclin-dependent kinase 18)   Male and Female 6 22 Liver -7.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CDK20 (cyclin-dependent kinase 20) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CDK20 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CDK3 (cyclin-dependent kinase 3) Using a linear mixed model, differential expression with age was identified in CDK3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDK5 (cyclin-dependent kinase 5)   Male and Female 26 106 Brain -7.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CDK5R1 (cyclin-dependent kinase 5, regulatory subunit 1 (p35)) Comparison of DNA methylation showed a significantly decreased methylation level of CDK5R1 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -17.2 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CDK5RAP3 (CDK5 regulatory subunit associated protein 3)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CDK5RAP3 (CDK5 regulatory subunit associated protein 3) Using a linear mixed model, differential expression with age was identified in CDK5RAP3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDKL2 (cyclin-dependent kinase-like 2 (CDC2-related kinase)) Using a linear mixed model, differential expression with age was identified in CDKL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21))   Male and Female 8 24 Muscle 14.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1))   Male and Female 20 75 Skeletal Muscle 50.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)) Using a linear mixed model, differential expression with age was identified in CDKN1A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDKN1C (cyclin-dependent kinase inhibitor 1C (p57, Kip2)) Gene expression showed a significant (p<E-3) decrease in the expression of CDKN1C in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary -69.33 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
CDKN2A (cyclin-dependent kinase inhibitor 2A) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CDKN2A and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Cdkn2a (cyclin-dependent kinase inhibitor 2A) p16 levels increase with aging in many tissues and is a marker of cellular senescence. Male and Female 1 -1 Whole Body     1947: Krishnamurthy et al. (2006) "p16INK4a induces an age-dependent decline in islet regenerative potential." Nature 443(7110):453-457 (16957737)|1945: Molofsky et al. (2006) "Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing." Nature 443(7110):448-452 (16957738)
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) Comparison of DNA methylation showed a significantly decreased methylation level of CDKN2B in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell -16.7 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) Comparison of DNA methylation showed a significantly increased methylation level of CDKN2B in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis 26.0 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CDPF1 (cysteine-rich, DPF motif domain containing 1) Using a linear mixed model, differential expression with age was identified in CDPF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CDRT4 (CMT1A duplicated region transcript 4) Using a linear mixed model, differential expression with age was identified in CDRT4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha)   Male and Female 20 75 Skeletal Muscle 28.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha) Using a linear mixed model, differential expression with age was identified in CEBPA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CEBPB (CCAAT/enhancer binding protein (C/EBP), beta)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Cebpd (CCAAT/enhancer binding protein (C/EBP), delta)   Male and Female 3 23 Hematological System 39.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CECR1 (cat eye syndrome chromosome region, candidate 1) Using a linear mixed model, differential expression with age was identified in CECR1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cecr5 (cat eye syndrome chromosome region, candidate 5 homolog (human))   Male and Female 6 22 Liver 15.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CELF6 (CUGBP, Elav-like family member 6) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypermethylation of CELF6 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CENPJ (centromere protein J) Using a linear mixed model, differential expression with age was identified in CENPJ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CENPM (centromere protein M) Using a linear mixed model, differential expression with age was identified in CENPM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CENPV (centromere protein V)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CEP135 (centrosomal protein 135kDa) Using a linear mixed model, differential expression with age was identified in CEP135 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CEP350 (centrosomal protein 350kDa)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CEP57 (centrosomal protein 57kDa) Gene expression showed a significant (p<E-3) increase in the expression of CEP57 in oocytes donated from older women (aged 37-39 years - both inclusive) compared to oocytes from younger women (aged 25-35 years) Female -1 -1 Ovary 86.0 <0.001 2714: Grøndahl et al. (2010) "Gene expression profiles of single human mature oocytes in relation to age." Hum. Reprod. 25(4):957-968 (20147335)
CEP63 (centrosomal protein 63kDa) Using a linear mixed model, differential expression with age was identified in CEP63 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CEP95 (centrosomal protein 95kDa) Using a linear mixed model, differential expression with age was identified in CEP95 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CERCAM (cerebral endothelial cell adhesion molecule) Using a linear mixed model, differential expression with age was identified in CERCAM in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CERCAM (cerebral endothelial cell adhesion molecule) Using a linear mixed model, differential expression with age was identified in CERCAM in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CES4A (carboxylesterase 4A) Using a linear mixed model, differential expression with age was identified in CES4A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CETN3 (centrin, EF-hand protein, 3) Using a linear mixed model, differential expression with age was identified in CETN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CFAP69 (cilia and flagella associated protein 69) Using a linear mixed model, differential expression with age was identified in C7orf63 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CFD (complement factor D (adipsin)) Comparison of DNA methylation showed a significantly decreased methylation level of CFD in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -21.7 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CFD (complement factor D (adipsin)) Comparison of DNA methylation showed a significantly increased methylation level of CFD in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell 22.2 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CFH (complement factor H) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 166.79 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CFH (complement factor H) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 138.86 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CFH (complement factor H) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CFH from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 210.85 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CFHR1 (complement factor H-related 1)   Male and Female 26 106 Brain 42.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CFHR1 (complement factor H-related 1) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 88.04 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CFHR1 (complement factor H-related 1) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 126.47 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CFHR1 (complement factor H-related 1) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CFHR1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 144.16 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CGGBP1 (CGG triplet repeat binding protein 1) Using a linear mixed model, differential expression with age was identified in CGGBP1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10)   Male and Female 20 75 Skeletal Muscle -3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10) Using a linear mixed model, differential expression with age was identified in CHCHD10 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CHCHD5 (coiled-coil-helix-coiled-coil-helix domain containing 5) Using a linear mixed model, differential expression with age was identified in CHCHD5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cherp (calcium homeostasis endoplasmic reticulum protein)   Male and Female 6 22 Liver -7.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CHI3L2 (chitinase 3-like 2) Using a linear mixed model, differential expression with age was identified in CHI3L2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Chi3l3 (chitinase 3-like 3)   Male and Female 3 23 Hematological System -53.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CHMP2A (chromatin modifying protein 2A)   Male and Female 20 75 Skeletal Muscle 3.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CHN1 (chimerin (chimaerin) 1)   Male and Female 26 106 Brain -6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CHN1 (chimerin (chimaerin) 1) Using a linear mixed model, differential expression with age was identified in CHN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CHN2 (chimerin 2) Using a linear mixed model, differential expression with age was identified in CHN2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Chordc1 (cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1)   Male and Female 2 26 Lung -8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CHPF (chondroitin polymerizing factor) Using a linear mixed model, differential expression with age was identified in CHPF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Chrnb1 (cholinergic receptor, nicotinic, beta polypeptide 1 (muscle))   Male and Female 8 24 Muscle 6.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CHRNE (cholinergic receptor, nicotinic, epsilon (muscle)) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CHRNE and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CHST13 (carbohydrate (chondroitin 4) sulfotransferase 13) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CHST13 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Chst2 (carbohydrate sulfotransferase 2)   Male and Female 2 26 Lung -10.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CHST7 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7) Using a linear mixed model, differential expression with age was identified in CHST7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Chsy1 (chondroitin sulfate synthase 1)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CHSY3 (chondroitin sulfate synthase 3) Using a linear mixed model, differential expression with age was identified in CHSY3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CIAO1 (cytosolic iron-sulfur assembly component 1) Using a linear mixed model, differential expression with age was identified in CIAO1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CIART (circadian associated repressor of transcription) Using a linear mixed model, differential expression with age was identified in C1orf51 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CIDEA (cell death-inducing DFFA-like effector a) Using a linear mixed model, differential expression with age was identified in CIDEA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cideb (cell death-inducing DNA fragmentation factor, alpha subunit-like effector B)   Male and Female 6 22 Liver -5.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CIRBP (cold inducible RNA binding protein)   Male and Female 20 75 Skeletal Muscle 2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CISH (cytokine inducible SH2-containing protein) Using a linear mixed model, differential expression with age was identified in CISH in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CISH (cytokine inducible SH2-containing protein) Using a linear mixed model, differential expression with age was identified in CISH in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ckap2 (cytoskeleton associated protein 2)   Male and Female 8 24 Muscle -4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CKB (creatine kinase, brain)   Male and Female 27 92 Kidney -10.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
CKB (creatine kinase, brain) Using a linear mixed model, differential expression with age was identified in CKB in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CKLF (chemokine-like factor)   Male and Female 20 75 Skeletal Muscle 4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CKMT2 (creatine kinase, mitochondrial 2 (sarcomeric))   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CLCF1 (cardiotrophin-like cytokine factor 1) Using a linear mixed model, differential expression with age was identified in CLCF1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Clcn3 (chloride channel 3)   Male and Female 2 26 Lung 3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CLCN6 (chloride channel, voltage-sensitive 6) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CLCN6 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CLDN5 (claudin 5) Using a linear mixed model, differential expression with age was identified in CLDN5 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLDN8 (claudin 8)   Male and Female 27 92 Kidney -17.0 <0.001 2993: Rodwell et al. (2004) "A transcriptional profile of aging in the human kidney." PLoS Biol. 2(12):e427 (15562319)
CLEC10A (C-type lectin domain family 10, member A) Using a linear mixed model, differential expression with age was identified in CLEC10A in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLEC10A (C-type lectin domain family 10, member A) Using a linear mixed model, differential expression with age was identified in CLEC10A in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Clec11a (C-type lectin domain family 11, member a)   Male and Female 8 24 Muscle -5.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Clec1b (C-type lectin domain family 1, member b)   Male and Female 2 26 Lung 22.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CLEC3B (C-type lectin domain family 3, member B) Comparison of DNA methylation showed a significantly decreased methylation level of CLEC3B in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -18.0 <0.001 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
Clic4 (chloride intracellular channel 4 (mitochondrial))   Male and Female 5 30 Anatomical System 4.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Clic4 (chloride intracellular channel 4 (mitochondrial))   Male and Female 6 22 Liver 3.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
Clint1 (clathrin interactor 1)   Male and Female 8 24 Muscle 5.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CLK2 (CDC-like kinase 2) Using a linear mixed model, differential expression with age was identified in CLK2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLK4 (CDC-like kinase 4) Using a linear mixed model, differential expression with age was identified in CLK4 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLMP (CXADR-like membrane protein) Using a linear mixed model, differential expression with age was identified in CLMP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLPSL2 (colipase-like 2) Using a linear mixed model, differential expression with age was identified in CLPSL2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLSTN1 (calsyntenin 1) Using a linear mixed model, differential expression with age was identified in CLSTN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLSTN3 (calsyntenin 3) Using a linear mixed model, differential expression with age was identified in CLSTN3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLTA (clathrin, light chain A) Using a linear mixed model, differential expression with age was identified in CLTA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of temporal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe 25.86 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 33.08 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 41.7 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 58.9 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 22.54 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 23.49 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 47.94 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 25.47 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 30.95 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLU (clusterin) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CLU from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 56.54 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CLYBL (citrate lyase beta like)   Male and Female 20 75 Skeletal Muscle -6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CMSS1 (cms1 ribosomal small subunit homolog (yeast)) Using a linear mixed model, differential expression with age was identified in CMSS1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) Using a linear mixed model, differential expression with age was identified in CMTM3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cmtm8 (CKLF-like MARVEL transmembrane domain containing 8)   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CNDP2 (CNDP dipeptidase 2 (metallopeptidase M20 family)) Using a linear mixed model, differential expression with age was identified in CNDP2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CNKSR3 (CNKSR family member 3) Using a linear mixed model, differential expression with age was identified in CNKSR3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CNN1 (calponin 1, basic, smooth muscle) Using a linear mixed model, differential expression with age was identified in CNN1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cnot8 (CCR4-NOT transcription complex, subunit 8)   Male and Female 8 24 Muscle -3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Cnpy4 (canopy 4 homolog (zebrafish))   Male and Female 2 26 Lung -5.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COA3 (cytochrome c oxidase assembly factor 3) Using a linear mixed model, differential expression with age was identified in COA3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COA5 (cytochrome c oxidase assembly factor 5) Using a linear mixed model, differential expression with age was identified in COA5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cog5 (component of oligomeric golgi complex 5)   Male and Female 6 22 Liver 52.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
COL11A1 (collagen, type XI, alpha 1) Using a linear mixed model, differential expression with age was identified in COL11A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL14A1 (collagen, type XIV, alpha 1) Using a linear mixed model, differential expression with age was identified in COL14A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Col16a1 (collagen, type XVI, alpha 1)   Male and Female 2 26 Lung -8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COL16A1 (collagen, type XVI, alpha 1) Using a linear mixed model, differential expression with age was identified in COL16A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL17A1 (collagen, type XVII, alpha 1) Using a linear mixed model, differential expression with age was identified in COL17A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL1A1 (collagen, type I, alpha 1) Using a linear mixed model, differential expression with age was identified in COL1A1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL1A1 (collagen, type I, alpha 1) Using a linear mixed model, differential expression with age was identified in COL1A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Col1a2 (collagen, type I, alpha 2)   Male and Female 2 26 Lung -11.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COL1A2 (collagen, type I, alpha 2) Using a linear mixed model, differential expression with age was identified in COL1A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL1A2 (collagen, type I, alpha 2) Using a linear mixed model, differential expression with age was identified in COL1A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Col27a1 (collagen, type XXVII, alpha 1)   Male and Female 2 26 Lung -4.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Col3a1 (collagen, type III, alpha 1)   Male and Female 2 26 Lung -11.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COL3A1 (collagen, type III, alpha 1) Using a linear mixed model, differential expression with age was identified in COL3A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL4A2 (collagen, type IV, alpha 2) Using a linear mixed model, differential expression with age was identified in COL4A2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL4A5 (collagen, type IV, alpha 5) Using a linear mixed model, differential expression with age was identified in COL4A5 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL4A6 (collagen, type IV, alpha 6) Using a linear mixed model, differential expression with age was identified in COL4A6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL5A1 (collagen, type V, alpha 1) Using a linear mixed model, differential expression with age was identified in COL5A1 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL5A2 (collagen, type V, alpha 2) Using a linear mixed model, differential expression with age was identified in COL5A2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Col6a3 (collagen, type VI, alpha 3)   Male and Female 2 26 Lung -9.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COL7A1 (collagen, type VII, alpha 1) Using a linear mixed model, differential expression with age was identified in COL7A1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COL8A2 (collagen, type VIII, alpha 2) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of COL8A2 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
COLQ (collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase) Using a linear mixed model, differential expression with age was identified in COLQ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COMMD1 (copper metabolism (Murr1) domain containing 1) Using a linear mixed model, differential expression with age was identified in COMMD1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Commd4 (COMM domain containing 4)   Male and Female 2 15 Hippocampus -1.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
COMMD7 (COMM domain containing 7) Using a linear mixed model, differential expression with age was identified in COMMD7 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COMT (catechol-O-methyltransferase) Using a linear mixed model, differential expression with age was identified in COMT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COPG1 (coatomer protein complex, subunit gamma 1) Using a linear mixed model, differential expression with age was identified in COPG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cops5 (COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana))   Male and Female 8 24 Muscle 2.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
COPS7B (COP9 signalosome subunit 7B) Using a linear mixed model, differential expression with age was identified in COPS7B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Coq5 (coenzyme Q5 homolog, methyltransferase (yeast))   Male and Female 8 24 Muscle -3.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Coq7 (demethyl-Q 7)   Male and Female 6 22 Liver 10.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
COQ9 (coenzyme Q9 homolog (S. cerevisiae))   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
CORIN (corin, serine peptidase) Using a linear mixed model, differential expression with age was identified in CORIN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CORO1B (coronin, actin binding protein, 1B) Using a linear mixed model, differential expression with age was identified in CORO1B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CORO6 (coronin 6) Using a linear mixed model, differential expression with age was identified in CORO6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
COX4I1 (cytochrome c oxidase subunit IV isoform 1)   Male and Female 20 75 Skeletal Muscle -2.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Cox6a1 (cytochrome c oxidase, subunit VI a, polypeptide 1)   Male and Female 2 26 Lung 1.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
COX7B (cytochrome c oxidase subunit VIIb)   Male and Female 22 73 Skeletal Muscle -4.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
Cox8b (cytochrome c oxidase, subunit VIIIb)   Male and Female 8 24 Muscle -2.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
Cpeb1 (cytoplasmic polyadenylation element binding protein 1)   Male and Female 6 22 Liver -53.0 <0.001 1334: Papaconstantinou et al. (2005) "Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice." Mech. Ageing Dev. 126(6-7):692-704 (15888324)|2981: NCBI GEO Dataset (2005) "Age effect on livers of long-lived Snell dwarf mutants" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2019)
CPN2 (carboxypeptidase N, polypeptide 2) Using a linear mixed model, differential expression with age was identified in CPN2 in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch, and random effects as family relationship and zygosity. Female 39 85 Adipose Tissue     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CPNE1 (copine I) Using a linear mixed model, differential expression with age was identified in CPNE1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cpne2 (copine II)   Male and Female 8 24 Muscle 42.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CPS1 (carbamoyl-phosphate synthetase 1, mitochondrial)   Male and Female 26 106 Brain 20.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CPT2 (carnitine palmitoyltransferase 2) Using a linear mixed model, differential expression with age was identified in CPT2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CPXM1 (carboxypeptidase X (M14 family), member 1) Using a linear mixed model, differential expression with age was identified in CPXM1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CPZ (carboxypeptidase Z) Using a linear mixed model, differential expression with age was identified in CPZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CRAT (carnitine O-acetyltransferase) Using a linear mixed model, differential expression with age was identified in CRAT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Creg1 (cellular repressor of E1A-stimulated genes 1)   Male and Female 2 26 Lung 3.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CREG1 (cellular repressor of E1A-stimulated genes 1) Using a linear mixed model, differential expression with age was identified in CREG1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like))   Male and Female 22 73 Skeletal Muscle 9.0 <0.001 2823: Welle et al. (2002) "Computational method for reducing variance with Affymetrix microarrays." BMC Bioinformatics 3:23 (12204100)
CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like))   Male and Female 20 75 Skeletal Muscle 6.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Crlf3 (cytokine receptor-like factor 3)   Male and Female 5 30 Anatomical System 3.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
CRMP1 (collapsin response mediator protein 1)   Male and Female 26 106 Brain -4.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CRNN (cornulin) Using a linear mixed model, differential expression with age was identified in CRNN in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CROT (carnitine O-octanoyltransferase) Using a linear mixed model, differential expression with age was identified in CROT in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CRP (C-reactive protein, pentraxin-related) Blood C-reactive protein (CRP) level was significant higher in thirty-seven elderly subjects (median age, 87, range 70-95 years; minimum: 0.04 mg\\dL, median: 0.41 mg\\dL, maximum: 51.62 mg\\dL) than in 22 young subjects (median age, 26, range 21-37 years; minimum: 0.08 mg\\dL, median: 0.21 mg\\dL, maximum: 0.70 mg\\dL). Male and Female 26 87 Plasma     2871: Ogawa et al. (2008) "The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly." Immun Ageing 5:13 (18950479)
CRTAP (cartilage associated protein) Using a linear mixed model, differential expression with age was identified in CRTAP in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cryba1 (crystallin, beta A1)   Male and Female 3 23 Hematological System 95.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CRYBB3 (crystallin, beta B3)   Male and Female 26 106 Brain -4.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CRYM (crystallin, mu)   Male and Female 26 106 Brain -12.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Cs (citrate synthase)   Male and Female 5 25 Skeletal Muscle 4.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
CSAD (cysteine sulfinic acid decarboxylase) Using a linear mixed model, differential expression with age was identified in CSAD in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CSF2 (colony stimulating factor 2 (granulocyte-macrophage))   Male and Female 26 106 Brain 6.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
CSN3 (casein kappa) Comparison of DNA methylation showed a significantly decreased methylation level of CSN3 in dermal fibroblasts from elderly women (aged 60-73 years old) compared to cells from younger women (aged 6-23 years old) Female 6 73 Dermis -15.0 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CSN3 (casein kappa) Comparison of DNA methylation showed a significantly increased methylation level of CSN3 in bone marrow mesenchymal stem cells obtained from elderly donors (aged 53-85 years old) compared to cells from younger donors (aged 21-50 years old) Male and Female 21 85 Mesenchymal Stem Cell 16.3 None 2751: Koch et al. (2011) "Specific age-associated DNA methylation changes in human dermal fibroblasts." PLoS ONE 6(2):e16679 (21347436)
CSNK1D (casein kinase 1, delta) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CSNK1D and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
CSPP1 (centrosome and spindle pole associated protein 1) Using a linear mixed model, differential expression with age was identified in CSPP1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Csprs (component of Sp100-rs)   Male and Female 2 26 Lung 27.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Csprs (component of Sp100-rs)   Male and Female 3 23 Hematological System 68.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Csrp1 (cysteine and glycine-rich protein 1)   Male and Female 5 25 Skeletal Muscle 14.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
CST3 (cystatin C) Using a linear mixed model, differential expression with age was identified in CST3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CST6 (cystatin E/M) Using a linear mixed model, differential expression with age was identified in CST6 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CSTB (cystatin B (stefin B)) Using a linear mixed model, differential expression with age was identified in CSTB in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CSTF3 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa) Using a linear mixed model, differential expression with age was identified in CSTF3 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CTAGE4 (CTAGE family, member 4)   Male and Female 20 75 Skeletal Muscle -4.0 <0.001 2828: Welle et al. (2004) "Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women." Exp. Gerontol. 39(3):369-377 (15036396)|2841: Welle et al. (2003) "Gene expression profile of aging in human muscle." Physiol. Genomics 14(2):149-159 (12783983)
Ctf1 (cardiotrophin 1)   Male and Female 8 24 Muscle 4.0 <0.001 2651: Beggs et al. (2004) "Alterations in the TGFbeta signaling pathway in myogenic progenitors with age." Aging Cell 3(6):353-361 (15569352)
CTHRC1 (collagen triple helix repeat containing 1) Using a linear mixed model, differential expression with age was identified in CTHRC1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ctla2a (cytotoxic T lymphocyte-associated protein 2 alpha)   Male and Female 2 15 Hippocampus 13.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
CTNNAL1 (catenin (cadherin-associated protein), alpha-like 1) Using a linear mixed model, differential expression with age was identified in CTNNAL1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CTSA (cathepsin A) Using a linear mixed model, differential expression with age was identified in CTSA in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CTSC (cathepsin C) Using a linear mixed model, differential expression with age was identified in CTSC in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ctse (cathepsin E)   Male and Female 5 30 Anatomical System -8.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
CTSF (cathepsin F) Using a linear mixed model, differential expression with age was identified in CTSF in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CTSG (cathepsin G) Using a linear mixed model, differential expression with age was identified in CTSG in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ctsk (cathepsin K)   Male and Female 2 24 Visual Apparatus 58.0 <0.001 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767)
CTSK (cathepsin K) Using a linear mixed model, differential expression with age was identified in CTSK in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ctss (cathepsin S)   Male and Female 2 24 Visual Apparatus 74.0 <0.001 2708: Ida et al. (2003) "Age-related changes in the transcriptional profile of mouse RPE/choroid." Physiol. Genomics 15(3):258-262 (14519767)
Ctss (cathepsin S)   Male and Female 5 30 Anatomical System 6.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Ctss (cathepsin S)   Male and Female 3 23 Hematological System -21.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
Ctss (cathepsin S)   Male and Female 2 15 Hippocampus 4.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
CTSV (cathepsin V) Using a linear mixed model, differential expression with age was identified in CTSV in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Ctsz (cathepsin Z)   Male and Female 5 30 Anatomical System 11.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
Ctsz (cathepsin Z)   Male and Female 2 15 Hippocampus 6.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
CTSZ (cathepsin Z) Using a linear mixed model, differential expression with age was identified in CTSZ in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CTSZ (cathepsin Z) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CTSZ and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Cttnbp2nl (CTTNBP2 N-terminal like)   Male and Female 3 23 Hematological System 12.0 <0.001 2882: Rossi et al. (2005) "Cell intrinsic alterations underlie hematopoietic stem cell aging." Proc. Natl. Acad. Sci. U.S.A. 102(26):9194-9199 (15967997)
CUL9 (cullin 9) Using a linear mixed model, differential expression with age was identified in CUL9 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
Cuta (cutA divalent cation tolerance homolog (E. coli))   Male and Female 2 15 Hippocampus -2.0 <0.001 2706: Verbitsky et al. (2004) "Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice." Learn. Mem. 11(3):253-260 (15169854)
CUX2 (cut-like homeobox 2)   Male and Female 26 106 Brain -19.0 <0.001 2742: Lu et al. (2004) "Gene regulation and DNA damage in the ageing human brain." Nature 429(6994):883-891 (15190254)
Cx3cl1 (chemokine (C-X3-C motif) ligand 1)   Male and Female 5 25 Skeletal Muscle 10.0 <0.001 2648: NCBI GEO Dataset (2006) "Caloric restriction effect on aged skeletal muscle" (http://www.ncbi.nlm.nih.gov/sites/GDSbrowser?acc=GDS2612)|2835: Edwards et al. (2007) "Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program." BMC Genomics 8:80 (17381838)
Cx3cl1 (chemokine (C-X3-C motif) ligand 1)   Male and Female 5 30 Anatomical System -2.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of temporal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Temporal Lobe -46.68 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of hippocampus CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus -31.6 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe -61.04 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of parietal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe -56.19 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe -61.1 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Gene expression showed a significant (p<0.01) decrease in the expression of frontal lobe CX3CL1 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe -58.02 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CX3CL1 (chemokine (C-X3-C motif) ligand 1) Methylation analysis of CpG sites in DNA from blood cells, spanning samples from 575 individuals within the age range of 0 to 78 years, showed a possitive correlation between hypomethylation of CX3CL1 and age. Male and Female 0 78 Blood     3456: Weidner, CI et al. (2014) "Aging of blood can be tracked by DNA methylation changes at just three CpG sites." Genome Biol. 15(2):R24 (24490752)
Cxcl1 (chemokine (C-X-C motif) ligand 1)   Male and Female 5 30 Anatomical System 33.0 <0.001 2926: Lee et al. (2000) "Gene-expression profile of the ageing brain in mice." Nat. Genet. 25(3):294-297 (10888876)
CXCL12 (chemokine (C-X-C motif) ligand 12) Gene expression showed a significant (p<0.01) decrease in the expression of hippocampus CXCL12 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus -30.87 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
Cxcl13 (chemokine (C-X-C motif) ligand 13)   Male and Female 2 26 Lung 20.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
Cxcl14 (chemokine (C-X-C motif) ligand 14)   Male and Female 2 26 Lung -8.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CXCL14 (chemokine (C-X-C motif) ligand 14) Using a linear mixed model, differential expression with age was identified in CXCL14 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)
CXCL16 (chemokine (C-X-C motif) ligand 16) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 100.64 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CXCL16 (chemokine (C-X-C motif) ligand 16) Gene expression showed a significant (p<0.01) increase in the expression of parietal lobe CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Parietal Lobe 78.92 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CXCL16 (chemokine (C-X-C motif) ligand 16) Gene expression showed a significant (p<0.01) increase in the expression of frontal lobe CXCL16 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Frontal Lobe 44.13 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
CXCL5 (chemokine (C-X-C motif) ligand 5) Gene expression showed a significant (p<0.01) increase in the expression of hippocampus CXCL5 from elderly (aged 69-99 years old) compared to cells from younger persons (aged 20-52 years old) Male and Female 20 99 Hippocampus 64.89 None 2984: Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (22824372)
Cxcr3 (chemokine (C-X-C motif) receptor 3)   Male and Female 2 26 Lung 20.0 <0.001 2785: Misra et al. (2007) "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiol. Genomics 31(3):429-440 (17726092)
CXorf40B (chromosome X open reading frame 40B) Using a linear mixed model, differential expression with age was identified in CXorf40B in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of Female twins. The linear mixed model was used to examine gene expression variability by age and confounding factors including fixed effect batch and RNA concentration, and random effects as family relationship and zygosity. Female 39 85 Skin     3454: Glass, D et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75 (23889843)

Reference: Digital Aging Atlas