Age associated genes in humans























































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































HAGRID


Common name


Symbol


187


1-Acylglycerol-3-phosphate O-acyltransferase 2


AGPAT2


87


3-Phosphoinositide dependent protein kinase 1


PDPK1


78


ABL proto-oncogene 1, non-receptor tyrosine kinase


ABL1


193


Activating transcription factor 2


ATF2


255


Adenylate cyclase 5


ADCY5


139


Alpha-2-macroglobulin


A2M


137


Amyloid beta (A4) precursor protein


APP


110


Androgen receptor


AR


264


Angiotensin II receptor, type 1


AGTR1


195


APEX nuclease (multifunctional DNA repair enzyme) 1


APEX1


102


Apolipoprotein C-III


APOC3


138


Apolipoprotein E


APOE


135


Apoptosis-inducing factor, mitochondrion-associated, 1


AIFM1


95


Aprataxin


APTX


251


Aryl hydrocarbon receptor nuclear translocator-like


ARNTL


9


ATM serine/threonine kinase


ATM


146


ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit


ATP5O


231


ATR serine/threonine kinase


ATR


69


B-cell CLL/lymphoma 2


BCL2


278


BCL2-antagonist/killer 1


BAK1


119


BCL2-associated X protein


BAX


186


Berardinelli-Seip congenital lipodystrophy 2 (seipin)


BSCL2


68


Bloom syndrome, RecQ helicase-like


BLM


188


BMI1 proto-oncogene, polycomb ring finger


BMI1


191


Brain-derived neurotrophic factor


BDNF


61


Breast cancer 1, early onset


BRCA1


79


Breast cancer 2, early onset


BRCA2


197


BUB1 mitotic checkpoint serine/threonine kinase B


BUB1B


240


BUB3 mitotic checkpoint protein


BUB3


133


Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit


CACNA1A


192


cAMP responsive element binding protein 1


CREB1


282


Cannabinoid receptor 1 (brain)


CNR1


304


Cardiotrophin 1


CTF1


244


Casein kinase 1, epsilon


CSNK1E


107


Catalase


CAT


223


Catenin (cadherin-associated protein), beta 1, 88kDa


CTNNB1


88


CCAAT/enhancer binding protein (C/EBP), alpha


CEBPA


89


CCAAT/enhancer binding protein (C/EBP), beta


CEBPB


265


CDGSH iron sulfur domain 2


CISD2


250


Cell division cycle 42


CDC42


247


Checkpoint kinase 2


CHEK2


262


Cholesteryl ester transfer protein, plasma


CETP


252


Clock circadian regulator


CLOCK


220


Clusterin


CLU


220


Clusterin


CLU


132


Coenzyme Q7 homolog, ubiquinone (yeast)


COQ7


287


Complement component 1, q subcomponent, A chain


C1QA


206


Connective tissue growth factor


CTGF


206


Connective tissue growth factor


CTGF


64


CREB binding protein


CREBBP


177


Cyclin A2


CCNA2


201


Cyclin-dependent kinase 1


CDK1


299


Cyclin-dependent kinase 7


CDK7


284


Cyclin-dependent kinase inhibitor 1A (p21, Cip1)


CDKN1A


226


Cyclin-dependent kinase inhibitor 2A


CDKN2A


288


Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)


CDKN2B


225


Delta-like 3 (Drosophila)


DLL3


291


Diacylglycerol O-acyltransferase 1


DGAT1


203


DNA-damage-inducible transcript 3


DDIT3


228


Drebrin 1


DBN1


94


E1A binding protein p300


EP300


18


E2F transcription factor 1


E2F1


76


Early growth response 1


EGR1


260


EGF containing fibulin-like extracellular matrix protein 1


EFEMP1


230


Elastin


ELN


121


Emerin


EMD


48


Epidermal growth factor


EGF


40


Epidermal growth factor receptor


EGFR


267


Epidermal growth factor receptor pathway substrate 8


EPS8


41


Erb-b2 receptor tyrosine kinase 2


ERBB2


52


Erythropoietin receptor


EPOR


216


Estrogen receptor 1


ESR1


216


Estrogen receptor 1


ESR1


189


Eukaryotic translation elongation factor 1 alpha 1


EEF1A1


266


Eukaryotic translation elongation factor 1 epsilon 1


EEF1E1


103


Eukaryotic translation elongation factor 2


EEF2


289


Eukaryotic translation initiation factor 5A2


EIF5A2


149


Excision repair cross-complementation group 1


ERCC1


11


Excision repair cross-complementation group 2


ERCC2


104


Excision repair cross-complementation group 3


ERCC3


261


Excision repair cross-complementation group 4


ERCC4


109


Excision repair cross-complementation group 5


ERCC5


92


Excision repair cross-complementation group 6


ERCC6


12


Excision repair cross-complementation group 8


ERCC8


115


Fas cell surface death receptor


FAS


50


FBJ murine osteosarcoma viral oncogene homolog


FOS


293


Fibroblast growth factor 21


FGF21


259


Fibroblast growth factor 23


FGF23


169


Fibroblast growth factor receptor 1


FGFR1


114


Flap structure-specific endonuclease 1


FEN1


171


Fms-related tyrosine kinase 1


FLT1


131


Forkhead box M1


FOXM1


124


Forkhead box O1


FOXO1


123


Forkhead box O3


FOXO3


183


Forkhead box O4


FOXO4


111


General transcription factor IIH, polypeptide 2, 44kDa


GTF2H2


237


Glutamate-cysteine ligase, catalytic subunit


GCLC


238


Glutamate-cysteine ligase, modifier subunit


GCLM


153


Glutathione peroxidase 1


GPX1


257


Glutathione peroxidase 4


GPX4


154


Glutathione reductase


GSR


156


Glutathione S-transferase alpha 4


GSTA4


157


Glutathione S-transferase pi 1


GSTP1


155


Glutathione synthetase


GSS


295


Glycogen synthase kinase 3 alpha


GSK3A


97


Glycogen synthase kinase 3 beta


GSK3B


300


Granulin


GRN


309


Growth differentiation factor 11


GDF11


122


Growth factor receptor-bound protein 2


GRB2


26


Growth hormone 1


GH1


1


Growth hormone receptor


GHR


2


Growth hormone releasing hormone


GHRH


222


Growth hormone releasing hormone receptor


GHRHR


212


H2A histone family, member X


H2AFX


212


H2A histone family, member X


H2AFX


38


Harvey rat sarcoma viral oncogene homolog


HRAS


159


Heat shock 60kDa protein 1 (chaperonin)


HSPD1


160


Heat shock 70kDa protein 1A


HSPA1A


161


Heat shock 70kDa protein 1B


HSPA1B


199


Heat shock 70kDa protein 8


HSPA8


152


Heat shock 70kDa protein 9 (mortalin)


HSPA9


74


Heat shock protein 90kDa alpha (cytosolic), class A member 1


HSP90AA1


125


Heat shock transcription factor 1


HSF1


101


Helicase, lymphoid-specific


HELLS


184


HESX homeobox 1


HESX1


176


High mobility group box 1


HMGB1


178


High mobility group box 2


HMGB2


151


Histone deacetylase 1


HDAC1


207


Histone deacetylase 2


HDAC2


207


histone deacetylase 2


HDAC2


25


Histone deacetylase 3


HDAC3


196


HMG-box transcription factor 1


HBP1


213


Homeobox B7


HOXB7


213


Homeobox B7


HOXB7


214


Homeobox C4


HOXC4


214


Homeobox C4


HOXC4


294


HtrA serine peptidase 2


HTRA2


98


Huntingtin


HTT


253


Hypermethylated in cancer 1


HIC1


65


Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)


HIF1A


297


Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta


IKBKB


30


Insulin


INS


42


Insulin receptor


INSR


32


Insulin receptor substrate 1


IRS1


34


Insulin receptor substrate 2


IRS2


28


Insulin-like growth factor 1 (somatomedin c)


IGF1


15


Insulin-like growth factor 1 receptor


IGF1R


29


Insulin-like growth factor 2


IGF2


279


Insulin-like growth factor binding protein 2, 36kDa


IGFBP2


73


Insulin-like growth factor binding protein 3


IGFBP3


308


Interferon beta


IFNB1


46


Interleukin 2


IL2


49


Interleukin 2 receptor, gamma


IL2RG


144


Interleukin 6


IL6


167


Interleukin 7


IL7


27


Interleukin 7 receptor


IL7R


215


Janus kinase 2


JAK2


215


Janus kinase 2


JAK2


45


Jun D proto-oncogene


JUND


172


Jun proto-oncogene


JUN


17


Klotho


KL


14


Lamin A/C


LMNA


181


Lamin B1


LMNB1


217


Leptin


LEP


217


Leptin


LEP


218


Leptin receptor


LEPR


218


Leptin receptor


LEPR


134


Low density lipoprotein receptor-related protein 2


LRP2


290


Macrophage migration inhibitory factor (glycosylation-inhibiting factor)


MIF


209


MAX dimerization protein 1


MXD1


209


MAX dimerization protein 1


MXD1


90


MAX interactor 1, dimerization protein


MXI1


210


MDM2 proto-oncogene, E3 ubiquitin protein ligase


MDM2


210


MDM2 proto-oncogene, E3 ubiquitin protein ligase


MDM2


221


Mechanistic target of rapamycin (serine/threonine kinase)


MTOR


221


Mechanistic target of rapamycin (serine/threonine kinase)


MTOR


173


Mediator complex subunit 1


MED1


292


Metallothionein 1E


MT1E


127


Methionine sulfoxide reductase A


MSRA


205


Microtubule-associated protein tau


MAPT


205


Microtubule-associated protein tau


MAPT


158


Mitochondrially encoded cytochrome c oxidase I


MT-CO1


168


Mitogen-activated protein kinase 14


MAPK14


175


Mitogen-activated protein kinase 3


MAPK3


163


Mitogen-activated protein kinase 8


MAPK8


174


Mitogen-activated protein kinase 9


MAPK9


179


Mitogen-activated protein kinase kinase kinase 5


MAP3K5


243


MutL homolog 1


MLH1


208


MYC associated factor X


MAX


208


MYC associated factor X


MAX


31


Nerve growth factor (beta polypeptide)


NGF


37


Nerve growth factor receptor


NGFR


24


Neuregulin 1


NRG1


44


Nibrin


NBN


229


Noggin


NOG


20


Nuclear factor of kappa light polypeptide gene enhancer in b-cells 2 (p49/p100)


NFKB2


82


Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1


NFKB1


219


Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha


NFKBIA


219


Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha


NFKBIA


307


Nuclear factor, erythroid 2-like 1


NFE2L1


283


Nuclear factor, erythroid 2-like 2


NFE2L2


43


Nuclear receptor corepressor 1


NCOR1


276


Nuclear receptor corepressor 2


NCOR2


75


Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


NR3C1


296


nudix (nucleoside diphosphate linked moiety X)-type motif 1


NUDT1


142


Paraoxonase 1


PON1


62


Peptidylprolyl cis/trans isomerase, NIMA-interacting 1


PIN1


141


Peroxiredoxin 1


PRDX1


58


Peroxisomal biogenesis factor 5


PEX5


55


Peroxisome proliferator-activated receptor alpha


PPARA


263


Peroxisome proliferator-activated receptor gamma


PPARG


256


Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha


PPARGC1A


63


Phosphatase and tensin homolog


PTEN


36


Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta


PIK3CB


286


Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha


PIK3CA


248


Phosphoenolpyruvate carboxykinase 1 (soluble)


PCK1


185


Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)


PIK3R1


57


Phospholipase C, gamma 2 (phosphatidylinositol-specific)


PLCG2


10


Plasminogen activator, urokinase


PLAU


47


Platelet-derived growth factor beta polypeptide


PDGFB


285


Platelet-derived growth factor receptor, alpha polypeptide


PDGFRA


51


Platelet-derived growth factor receptor, beta polypeptide


PDGFRB


60


Poly (ADP-ribose) polymerase 1


PARP1


204


Polymerase (DNA directed), alpha 1, catalytic subunit


POLA1


236


Polymerase (DNA directed), beta


POLB


118


Polymerase (DNA directed), delta 1, catalytic subunit


POLD1


72


Polymerase (DNA directed), gamma


POLG


268


Potassium channel, voltage gated shaker related subfamily A, member 3


KCNA3


4


POU class 1 homeobox 1


POU1F1


254


Pregnancy-associated plasma protein A, pappalysin 1


PAPPA


224


Presenilin 1


PSEN1


113


proliferating cell nuclear antigen


PCNA


242


Pro-melanin-concentrating hormone


PMCH


96


Promyelocytic leukemia


PML


5


PROP paired-like homeobox 1


PROP1


198


Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)


PTGS2


99


Protein kinase C, alpha


PRKCA


54


Protein kinase C, delta


PRKCD


106


Protein kinase, DNA-activated, catalytic polypeptide


PRKDC


227


Protein phosphatase 1, catalytic subunit, alpha isozyme


PPP1CA


246






Protein phosphatase, Mg2+/Mn2+ dependent, 1D








PPM1D


166


Protein tyrosine kinase 2


PTK2


165


Protein tyrosine kinase 2 beta


PTK2B


33


Protein tyrosine phosphatase, non-receptor type 1


PTPN1


19


Protein tyrosine phosphatase, non-receptor type 11


PTPN11


162


Protein-L-isoaspartate (D-aspartate) O-methyltransferase


PCMT1


280


Pyrroline-5-carboxylate reductase 1


PYCR1


84


RAD51 recombinase


RAD51


147


RAD52 homolog, DNA repair protein


RAD52


128


RecQ helicase-like 4


RECQL4


145


Regucalcin


RGN


67


Replication protein A1, 70kDa


RPA1


56


Ret proto-oncogene


RET


120


Retinoblastoma 1


RB1


249


Rho GTPase activating protein 1


ARHGAP1


241


Ribonucleic acid export 1


RAE1


303


RPTOR independent companion of MTOR, complex 2


RICTOR


70


S100 calcium binding protein B


S100B


277


Sad1 and UNC84 domain containing 1


SUN1


298


Sequestosome 1


SQSTM1


93


Serine/threonine kinase 11


STK11


301


Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1


SERPINE1


3


SHC (Src homology 2 domain containing) transforming protein 1


SHC1


22


Signal transducer and activator of transcription 3 (acute-phase response factor)


STAT3


23


Signal transducer and activator of transcription 5a


STAT5A


21


Signal transducer and activator of transcription 5b


STAT5B


200


SIN3 transcription regulator family member A


SIN3A


150


Sirtuin 1


SIRT1


275


Sirtuin 3


SIRT3


239


Sirtuin 6


SIRT6


269


Sirtuin 7


SIRT7


211


Small ubiquitin-like modifier 1


SUMO1


211


Small ubiquitin-like modifier 1


SUMO1


270


Solute carrier family 13 (sodium/sulfate symporter), member 1


SLC13A1


53


Somatostatin


SST


100


Somatostatin receptor 3


SSTR3


170


Sp1 transcription factor


SP1


302


SprT-like N-terminal domain


SPRTN


245


STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase


STUB1


182


Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa


SDHC


130


Superoxide dismutase 1, soluble


SOD1


129


Superoxide dismutase 2, mitochondrial


SOD2


271


Suppressor of cytokine signaling 2


SOCS2


140


Synuclein, gamma (breast cancer-specific protein 1)


SNCG


180


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa


TAF1


194


TATA box binding protein


TBP


8


Telomerase reverse transcriptase


TERT


7


Telomerase rna component


TERC


105


Telomeric repeat binding factor (NIMA-interacting) 1


TERF1


116


Telomeric repeat binding factor 2


TERF2


16


Thioredoxin


TXN


305


TNF receptor-associated protein 1


TRAP1


83


Topoisomerase (DNA) I


TOP1


80


Topoisomerase (DNA) II alpha


TOP2A


81


Topoisomerase (DNA) II beta


TOP2B


148


Topoisomerase (DNA) III beta


TOP3B


59


Transcription factor 3


TCF3


190


Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)


TFAP2A


202


Transcription factor Dp-1


TFDP1


91


Transforming growth factor, beta 1


TGFB1


306


Transient receptor potential cation channel subfamily V member 1


TRPV1


273


Tripeptidyl peptidase II


TPP2


86


Tumor necrosis factor


TNF


6


Tumor protein p53


TP53


274


Tumor protein p53 binding protein 1


TP53BP1


234


Tumor protein p63


TP63


281


Tumor protein p73


TP73


164


Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta


YWHAZ


66


Ubiquitin B


UBB


136


Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)


UCHL1


85


Ubiquitin-conjugating enzyme E2I


UBE2I


258


Uncoupling protein 1 (mitochondrial, proton carrier)


UCP1


235


Uncoupling protein 2 (mitochondrial, proton carrier)


UCP2


232


Uncoupling protein 3 (mitochondrial, proton carrier)


UCP3


35


V-akt murine thymoma viral oncogene homolog 1


AKT1


71


Valosin containing protein


VCP


77


Vascular endothelial growth factor A


VEGFA


39


V-myc avian myelocytomatosis viral oncogene homolog


MYC


143


v-rel avian reticuloendotheliosis viral oncogene homolog A


RELA


13


Werner syndrome, RecQ helicase-like


WRN


126


Xeroderma pigmentosum, complementation group A


XPA


112


X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)


XRCC5


117


X-ray repair complementing defective repair in Chinese hamster cells 6


XRCC6


233


Zinc metallopeptidase STE24


ZMPSTE24

Reference: HAGR