Anti-longevity genes in Mus Musculus

Name

Symbol

Entrez ID

Max average lifespan change

adenylate cyclase 5

Adcy5

224129

30%  Upregulatedd

Adrenergic receptor, alpha 1b

Adra1b

11548

11%  Downregulated

Angiotensin II receptor, type 1a

Agtr1a

11607

26%  Upregulatedd

thymoma viral proto-oncogene 1

Akt1

11651

12%  Upregulatedd

thymoma viral proto-oncogene 2

Akt2

11652

9%  Upregulatedd

Cyclin-dependent kinase inhibitor 1A

Cdkn1a

12575

Upregulatedd

demethyl-Q 7

Coq7

12850

30%  Upregulatedd

Cardiotrophin 1

Ctf1

13019

18%  Upregulatedd

diacylglycerol O-acyltransferase 1

Dgat1

13350

23%  Upregulatedd

Eukaryotic translation elongation factor 1 epsilon 1

Eef1e1

66143

50%  Downregulated

eukaryotic translation initiation factor 5A2

Eif5a2

208691

Downregulated

Epidermal growth factor receptor pathway substrate 8

Eps8

13860

37%  Upregulatedd

Growth hormone

Gh

14599

Downregulated

Growth hormone receptor

Ghr

14600

40%  Upregulatedd

growth hormone releasing hormone

Ghrh

14601

46%  Upregulatedd

Growth hormone releasing hormone receptor

Ghrhr

14602

20%  Upregulatedd

glia maturation factor beta

GMFB

2764

6%  Downregulated

Glutathione peroxidase 4

Gpx4

625249

7%  Upregulatedd

glutathione S-transferase, alpha 4

Gsta4

14860

13%  Upregulatedd

Huntingtin

Htt

15194

18%  Upregulatedd

Insulin-like growth factor 1 receptor

Igf1r

16001

40%  Upregulatedd

inhibitor of kappaB kinase beta

Ikbkb

16150

23%  Upregulatedd

Insulin receptor

Insr

16337

33%  Upregulatedd

insulin receptor substrate 1

Irs1

16367

18%  Upregulatedd

insulin receptor substrate 2

Irs2

384783

18%  Upregulatedd

Potassium voltage-gated channel, shaker-related subfamily, member 3

Kcna3

16491

22%  Upregulatedd

macrophage migration inhibitory factor

Mif

17319

16%  Upregulatedd

myostatin

Mstn

17700

15%  Upregulatedd

Mdm2, transformed 3T3 cell double minute p53 binding protein

Mtbp

105837

20%  Upregulatedd

mechanistic target of rapamycin (serine/threonine kinase)

Mtor

56717

20%  Upregulatedd

myelocytomatosis oncogene

Myc

17869

21%  Upregulatedd

Pregnancy-associated plasma protein A

Pappa

18491

30%  Upregulatedd

period circadian clock 2

Per2

18627

Upregulatedd

POU domain, class 1, transcription factor 1

Pou1f1

18736

40%  Upregulatedd

protein kinase, cAMP dependent regulatory, type II beta

Prkar2b

19088

14%  Upregulatedd

Prophet of Pit1, paired-like homeodomain transcription factor

Prop1

19127

Upregulatedd

ribosomal protein S6 kinase, polypeptide 1

Rps6kb1

72508

19%  Upregulatedd

serine (or cysteine) peptidase inhibitor, clade E, member 1

Serpine1

18787

Upregulatedd

SHC (Src homology 2 domain containing) transforming protein 1

Shc1

20416

30%  Upregulatedd

Solute carrier family 13 (sodium/sulfate symporters), member 1

Slc13a1

55961

25%  Upregulatedd

surfeit gene 1

Surf1

20930

20%  Upregulatedd

telomeric repeat binding factor 2

Terf2

21750

Downregulated

Transformation related protein 53 binding protein 1

Trp53bp1

27223

Upregulatedd

transient receptor potential cation channel, subfamily V, member 1

Trpv1

193034

16%  Upregulatedd

ubiquitin D

Ubd

24108

20%  Upregulatedd

Reference: HAGR