|[Frontiers in Bioscience 1, e34-41, July 1, 1996]|
PIG alpha1,3GALACTOSYLTRANSFERASE: A MAJOR TARGET FOR GENETIC MANIPULATION IN XENOTRANSPLANTATION
Karen Strahan, Andrew Preece and Kenth Gustafsson
Division of Cell & Molecular Biology, Institute of Child Health, University of London, 30 Guilford St., London WC1N 1EH, UK
Received 06/21/96; Accepted 07/02/96; On-line 07/08/96
From several recent studies, it seems clear that the Gala1,3Gal epitope is the major target for human anti-pig NAb leading to the events that precipitate the HAR. Therefore, attempts are being made to produce transgenic pigs with reduced levels of expression of the Gala1,3Gal epitope. One attractive option will be to breed such animals with other transgenic pigs, notably pigs expressing human complement inhibitors. The offsprings of such animals are likely to provide organs for human transplantation that evade the HAR, as well as lessen the likelihood of production of high titers of non-pre-formed anti-Gala1,3Gal Ab (e.g. IgG).