FRONTIERS IN BIOSCIENCE;
GENE KNOCKOUT DATABASE





TENASCIN-C

Lack of influence on development, adulthood, life span, and fecundity
Lack of alteration in the regeneration of the sciatic nerve, after axotomy
Deposition of collagen one, fibulin-two, and nidogen during wound healing similar to wild-type
Diminished appearance of fibronectin in wounds

Forsberg, 1996
Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
Proc. Natl. Acad. Sci. U.S.A. 93, 6594-6599 (1996) [96270586]

METHODOLOGY ( FROM T-BASE)

((tenascin))

Line Name DNA Construct
1. beta-1 (+/-) ES cel A 5' mouse beta-1 integrin cDNA probe was provided by R.O. Hynes (REG:97212) and used to isolate several overlapping cosmid clones from a mouse genomic library from 129/....
2. TN (+/-) A genomic DNA clone containing exon 2 of mouse tenascin (TN) (also known by the synonyms cytotactin, hexabrachion, J1 glycoprotein, myotendinous antigen, and glioma mese....
3. beta-1 (-/-) ES cel A 5' mouse beta-1 integrin cDNA probe was provided by R.O. Hynes (REG:97212) and used to isolate several overlapping cosmid clones from a mouse genomic library from 129/....
4. P(zero) (-/-) The XbaI-HindIII fragment from lambda phage MP(zero)G118 containing the first coding exon of the P(zero) gene was subcloned into pBluescript KS(+)....
5. TGF-beta3 (exon 6) A replacement-type targeting vector was constructed in which exon 6 of the transforming growth factor, beta-3 (Tgfb3) gene was replaced with a neomycin-resistance gene d....
6. TN (-/-) A genomic DNA clone containing exon 2 of mouse tenascin (TN) (also known by the synonyms cytotactin, hexabrachion, J1 glycoprotein, myotendinous antigen, and glioma mese....
7. Mag (-/-) A genomic clone containing the entire Mag (myelin-associated glycoprotein) gene was isolated from a mouse C57BL/6J genomic library by hybridization with the rat 0.95b


Database Links

OMIM MEDLINE Citations Protein Links Nucleotide Links Gene Map GDB 30 MEDLINE Neighbors