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AMINOALKYLAZIRIDINES AS SUBSTRATES AND INHIBITORS OF LYSYL OXIDASE: SPECIFIC INACTIVATION OF THE ENZYME BY N-(5-AMINOPENTYL)AZIRIDINE
Narasimhan Nagan1, Patrick S. Callery2 and Herbert M. Kagan1
1 Department of Biochemistry, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, and the 2 Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506
Received 4/2/98 Accepted4/6/98
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Materials and Methods
- 3.1. Enzyme purification and assay
- 4. Results
- 4.1 Substrate potential of aminoalkylaziridines
4.2 Competitive nature of inhibition
4.3 Irreversibility of inhibition
- 5. Discussion
- 6. Acknowledgement
- 7. References
- 8. Entire manuscript
Key words: Enzymology, Connective Tissue, Lysyl Oxidase, Aminoalkylaziridines, Enzyme Inhibition
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