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IMMUNE REGULATION BY CD40-CD40-L INTERACTIONS
Cees van Kooten and Jacques Banchereau
Dept of Nephrology, Leiden University Hospital, Leiden, the Netherlands and Schering-Plough, Laboratory for Immunological Research, Dardilly, France
Received 11/14/96; Accepted 12/02/96; On-line 01/01/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Immune regulation by CD40-CD40-L interactions
- 3.1. Structure and expression of CD40 and its ligand
- 3.2. CD40 signal transduction
- 3.3. Functions of CD40 in vitro
- 3.3.1. B lymphocytes
- 3.3.2. Monocytes and dendritic cells
- 3.3.3. Non-hematopoietic cells
- 3.4. In vivo functions of CD40/CD40-L interactions
- 3.4.1. Hyper-IgM syndrome
- 3.4.2. Formation of germinal centers
- 3.4.3. CD40/CD40-L: treatment of autoimmunity
- 3.4.4. CD40/CD40-L: induction of transplantation tolerance
- 4. Concluding remarks
- 5. References
- 6. Entire manuscript
Keywords: Basic science review, Immunology, CD40, CD40-L
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