[Frontiers in Bioscience 2, d61-77, February 15, 1997]

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Dieter Kabelitz & Ottmar Janssen

Department of Immunology, Paul-Ehrlich-Institute, Langen, Germany

Received 1/24/97; Accepted 1/31/97 On-line 2/15/97


1. Abstract
2. Introduction
2.1 Features of apoptosis
2.2 Role of death molecules
2.3 Apoptosis in intrahymic T-cell development
3. Activation-induced cell death (AICD) of mature T-Lymphocytes
3.1 Induction via the CD3/T-cell receptor molecular complex
3.2 AICD triggered by superantigens
3.3 AICD triggered by conventional antigens
3.4 Role of Fas/Fas-Ligand interaction in antigen-induced AICD
4. Clinical implications
4.1 Role of AICD in peripheral T-cell tolerance
4.2 Therapeutical perspectives in autoimmune diseases
5. Concluding remarks
6. References
7. Entire manuscript

Key words: Antigen, Apoptosis, Autoimmune Disease, Immunology, Peripheral Tolerance, Programmed Cell Death, T-Lymphocytes, 47

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