[Frontiers in Bioscience 1, e42-54, August 1,1996]
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CAVEAT LECTOR



MYCOPLASMAS AND HIV INFECTION: FROM EPIDEMIOLOGY TO THEIR INTERACTION WITH IMMUNE CELLS

Catherine Brenner, Olivier Neyrolles, Alain Blanchard

Institut Pasteur, Unité d'Oncologie Virale, Département SIDA et Rétrovirus, 28, rue du Dr. Roux, 75724 Paris Cedex 15, France

Received 07/05/96; Accepted 07/09/96; On-line 08/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. In vitro synergy between HIV and mycoplasma cell killing activity
4. Mycoplasma isolation from HIV-infected patients
5. Prevalence of mycoplasmas in HIV-infected patients
5.1. Immuno-histochemistry evidence of mycoplasmas in tissues from AIDS patients
5.2. PCR-based detection of mycoplasmas
5.3. Seroprevalence of M. penetrans and M. fermentans
5.3.1. M. penetrans
5.3.2. M. fermentans
6. M. fermentans and M. penetrans cytopathogenicity
6.1. Cell invasion
6.2. Mycoplasma adherence to host cells
7. Mycoplasma interactions with the immune system
7.1. Immune cell activators
7.2. Antigenic surface variation and immune escape
7.3. Molecular mimicry
8. Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: mollicute/mycoplasma/Mycoplasma fermentans/Mycoplasma penetrans/ AIDS/HIV/cofactor/immune response/epidemiology