[Frontiers in Bioscience 1, d340-357, December 1, 1996]
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CAVEAT LECTOR



MOLECULAR AND CELLULAR BIOLOGY OF INTERLEUKIN-6 AND ITS RECEPTOR

Evan T. Keller1,2,3, Jon Wanagat1, W.B. Ershler1,3

1Glennan Center for Geriatrics and Gerontology, Departments of 2Pathology and 3Internal Medicine, Eastern Virginia Medical School.

Received 10/21/96; Accepted 11/01/96; On-line //96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. An overview of interleukin-6
3.1. Physiology and pathophysiology of interleukin-6
3.2. Interleukin-6 structure and function
3.3. Control of interleukin-6 promoter activity
4. Steroids and regulation of interleukin-6 expression
4.1. Glucocorticoid and interleukin-6 expression
4.2. Estrogen and interleukin-6 expression
4.3. Androgen and interleukin-6 expression
5. The interleukin-6 receptor
5.1. The interleukin-6 receptor: Structure and function
5.2. Expression of the interleukin-6 receptor
6. Summary
7. Acknowledgments
8. References
9. Entire manuscript

Keywords: Gerontology, Immunology, Cytokines, Interleukin-6, Interleukin-6 receptor gp80, osteoporosis, prostate cancer