RAS induced SASP in Fibroblasts (day 7)

Comparison

UniProtIds

Protein Description

Genes

Log2 Ratio

Std. Dev.

PValue

QValue

GO Biological Process

GO Molecular Process

GO Cellular Process

Ratios

Unique Peptides

Elution Groups

Elution Group

SEN / CTL

P20700

Lamin-B1

LMNB1

4.88

1.02

0.0715

0.0389

structural molecule activity,protein binding,phosp...

nuclear envelope,nuclear inner membrane,lamin fila...

3

59

97

_LQIELGK_.2|_AGGPTTPLSPTR_.2|_LAVYIDK_.2|_ALYETELA...

SEN / CTL

P23246

Splicing factor, proline- and glutamine-rich

SFPQ

4.04

0.33

0.000148

0.000161

negative regulation of transcription from RNA poly...

nucleotide binding,transcription regulatory region...

chromatin,nucleus,nucleoplasm,cytoplasm,nuclear ma...

5

49

90

_GIVEFASKPAAR_.3|_GIVEFASKPAAR_.2|_YGEPGEVFINK_.2|...

SEN / CTL

P49321

Nuclear autoantigenic sperm protein

NASP

3.79

0.47

0.00555

0.00432

blastocyst development,DNA replication,DNA replica...

protein binding,histone binding,Hsp90 protein bind...

nuclear chromatin,nucleus,nucleoplasm,cytoplasm,pr...

4

59

92

_SGNVAELALK_.2|_SLLELAR_.2|_SIEVIENR_.2|_EAQLYAAQA...

SEN / CTL

Q96AE4

Far upstream element-binding protein 1

FUBP1

3.27

1.09

0.0079

0.00584

regulation of transcription, DNA-templated,transcr...

single-stranded DNA binding,transcription factor a...

nucleus,nucleoplasm

7

39

63

_IAQITGPPDR_.2|_LLDQIVEK_.2|_GTPQQIDYAR_.2|_ITGDPY...

SEN / CTL

O14979

Heterogeneous nuclear ribonucleoprotein D-like

HNRNPDL

3.1

0.22

2.03e-7

3.57e-7

transcription, DNA-templated,regulation of transcr...

nucleotide binding,DNA binding,RNA binding,protein...

nucleoplasm,cytoplasm,extracellular exosome

9

22

35

_FGEVVDC[+57]TIK_.2|_DLTEYLSR_.2|_RGFC[+57]FITYTDE...

SEN / CTL

P14866

Heterogeneous nuclear ribonucleoprotein L

HNRNPL

2.95

0.17

0.00677

0.00511

regulation of alternative mRNA splicing, via splic...

nucleotide binding,RNA binding,mRNA 3'-UTR binding...

nucleus,nucleoplasm,cytosol,membrane,intracellular...

3

43

90

_LC[+57]FSTAQHAS_.2|_LNVC[+57]VSK_.2|_FSTPEQAAK_.2...

SEN / CTL

Q92499

ATP-dependent RNA helicase DDX1

DDX1

2.84

0.32

0.0342

0.0207

spliceosomal complex assembly,double-strand break ...

DNA binding,chromatin binding,transcription cofact...

nucleus,nucleoplasm,cytoplasm,cytosol,cytoplasmic ...

4

56

98

_LNLSQVR_.2|_ELLIIGGVAAR_.2|_FLIC[+57]TDVAAR_.2|_M...

SEN / CTL

P26599

Polypyrimidine tract-binding protein 1

PTBP1

2.7

0.57

0.0000272

0.0000343

alternative mRNA splicing, via spliceosome,regulat...

nucleotide binding,RNA binding,protein binding,pol...

nucleoplasm,nucleolus,membrane,extracellular exoso...

12

35

87

_LSLDGQNIYNAC[+57]C[+57]TLR_.2|_LSLDGQNIYNAC[+57]C...

SEN / CTL

P62333

26S protease regulatory subunit 10B

PSMC6

2.7

0.12

0.0927

0.0486

MAPK cascade,protein polyubiquitination,stimulator...

protein binding,ATP binding,ATPase activity,TBP-cl...

proteasome complex,nucleus,nucleoplasm,cytosol,pro...

2

28

44

_AVASQLDC[+57]NFLK_.2|_VVSSSIVDKYIGESAR_.3|_ELREVI...

SEN / CTL

P22626

Heterogeneous nuclear ribonucleoproteins A2/B1

HNRNPA2B1

2.66

1.33

6.05e-16

2.56e-15

negative regulation of transcription from RNA poly...

nucleotide binding,RNA binding,mRNA 3'-UTR binding...

chromosome, telomeric region,nucleus,nucleoplasm,s...

48

47

96

_GGNFGFGDSR_.2|_GGGGNFGPGPGSNFR_.2|_GGGGNFGPGPGSNF...

SEN / CTL

P31942

Heterogeneous nuclear ribonucleoprotein H3

HNRNPH3

2.64

0.31

0.000584

0.000575

mRNA splicing, via spliceosome,RNA processing,RNA ...

nucleotide binding,RNA binding,protein binding,pol...

nucleus,nucleoplasm,spliceosomal complex

6

14

32

_EIAENALGK_.2|_STGEAFVQFASK_.2|_VHIDIGADGR_.2|_ATE...

SEN / CTL

P38159

RNA-binding motif protein, X chromosome

RBMX

2.63

0.07

0.00000322

0.00000473

regulation of alternative mRNA splicing, via splic...

nucleotide binding,core promoter binding,chromatin...

extracellular space,nucleus,nucleoplasm,nuclear eu...

5

32

43

_ALEAVFGK_.2|_LFIGGLNTETNEK_.2|_GFAFVTFESPADAKDAAR...

SEN / CTL

P09651

Heterogeneous nuclear ribonucleoprotein A1

HNRNPA1

2.56

0.83

1.5e-10

3.73e-10

mRNA splicing, via spliceosome,mRNA processing,RNA...

nucleotide binding,single-stranded DNA binding,RNA...

nucleus,nucleoplasm,spliceosomal complex,cytoplasm...

27

41

92

_KLFIGGLSFETTDESLR_.3|_KLFIGGLSFETTDESLR_.2|_SESPK...

SEN / CTL

Q15233

Non-POU domain-containing octamer-binding protein

NONO

2.55

0.25

1.1e-8

2.32e-8

mRNA splicing, via spliceosome,DNA repair,DNA reco...

nucleotide binding,transcription regulatory region...

nucleus,nucleoplasm,nucleolus,membrane,nuclear mat...

11

43

99

_AVVIVDDR_.2|_GIVEFSGKPAAR_.3|_GIVEFSGKPAAR_.2|_AL...

SEN / CTL

P52272

Heterogeneous nuclear ribonucleoprotein M

HNRNPM

2.54

0.23

0.000292

0.000306

alternative mRNA splicing, via spliceosome,mRNA sp...

nucleotide binding,RNA binding,protein binding,pro...

nucleoplasm,spliceosomal complex,nucleolus,integra...

5

58

148

_AFITNIPFDVK_.2|_VGQTIER_.2|_QGGGGGGGSVPGIER_.2|_M...

SEN / CTL

P11413

Glucose-6-phosphate 1-dehydrogenase

G6PD

2.53

0.25

0.000071

0.0000835

glucose metabolic process,pentose-phosphate shunt,...

glucose-6-phosphate dehydrogenase activity,protein...

nucleus,cytoplasm,cytosol,cytoplasmic side of plas...

8

50

86

_VQPNEAVYTK_.2|_LPDAYER_.2|_VGFQYEGTYK_.2|_IIVEKPF...

SEN / CTL

P52926

High mobility group protein HMGI-C

HMGA2

2.49

0.97

0.0000719

0.0000843

negative regulation of transcription from RNA poly...

regulatory region DNA binding,core promoter bindin...

nuclear chromosome,nucleus,nucleoplasm,protein-DNA...

13

5

7

_GEGAGQPSTSAQGQPAAPAPQKR_.3|_KQQQEPTGEPSPK_.3|_KQQ...

SEN / CTL

Q00839

Heterogeneous nuclear ribonucleoprotein U

HNRNPU

2.49

0.59

0.00437

0.0035

mRNA splicing, via spliceosome,osteoblast differen...

core promoter binding,DNA binding,RNA binding,prot...

nucleus,nucleoplasm,cell surface,membrane,intracel...

6

64

129

_SSGPTSLFAVTVAPPGAR_.2|_SSGPTSLFAVTVAPPGAR_.3|_LNT...

SEN / CTL

P35637

RNA-binding protein FUS

FUS

2.46

0.07

0.0256

0.0161

mRNA splicing, via spliceosome,cellular response t...

nucleotide binding,DNA binding,transcription coact...

nucleus,nucleoplasm,polysome,perikaryon,dendritic ...

2

17

37

_AAIDWFDGKEFSGNPIK_.3|_AAIDWFDGKEFSGNPIK_.2|_LKGEA...

SEN / CTL

P31943

Heterogeneous nuclear ribonucleoprotein H

HNRNPH1

2.44

0.67

6.22e-8

1.2e-7

mRNA splicing, via spliceosome,RNA processing,fibr...

nucleotide binding,RNA binding,protein binding,pol...

nucleus,nucleoplasm,cytosol,membrane,catalytic ste...

21

27

53

_ATENDIYNFFSPLNPVR_.2|_ATENDIYNFFSPLNPVR_.3|_HTGPN...

SEN / CTL

Q13185

Chromobox protein homolog 3

CBX3

2.41

0.07

0.00000682

0.00000956

chromatin remodeling,transcription, DNA-templated,...

protein binding,enzyme binding,protein domain spec...

chromosome, centromeric region,condensed chromosom...

5

13

22

_KVEEAEPEEFVVEK_.3|_KVEEAEPEEFVVEK_.2|_LTWHSC[+57]...

SEN / CTL

P43487

Ran-specific GTPase-activating protein

RANBP1

2.34

0.47

0.02

0.013

G1/S transition of mitotic cell cycle,RNA export f...

GDP-dissociation inhibitor activity,protein bindin...

nucleus,nuclear envelope,cytoplasm,centrosome,cyto...

10

10

21

_FLNAENAQK_.2|_FASENDLPEWK_.2|_FASENDLPEWKER_.3|_A...

SEN / CTL

Q12906

Interleukin enhancer-binding factor 3

ILF3

2.29

0.21

0.0000406

0.0000497

transcription, DNA-templated,protein phosphorylati...

DNA binding,RNA binding,double-stranded RNA bindin...

nucleus,nucleoplasm,nucleolus,cytoplasm,mitochondr...

6

70

118

_SC[+57]VIVIR_.2|_AYAALAALEK_.2|_C[+57]LAALASLR_.2...

SEN / CTL

P09429

High mobility group protein B1

HMGB1

2.28

0.71

5.25e-8

1.03e-7

negative regulation of transcription from RNA poly...

four-way junction DNA binding,bubble DNA binding,l...

condensed chromosome,extracellular region,extracel...

22

26

57

_RPPSAFFLFC[+57]SEYRPK_.3|_RPPSAFFLFC[+57]SEYRPK_....

SEN / CTL

P55786

Puromycin-sensitive aminopeptidase

NPEPPS

2.26

0.33

0.0353

0.0213

protein polyubiquitination,proteolysis,peptide cat...

aminopeptidase activity,zinc ion binding,peptide b...

nucleus,cytoplasm,cytosol,extracellular exosome,pl...

5

55

85

_AGIISTVEVLK_.2|_LGLQNDLFSLAR_.2|_LNLGTVGFYR_.2|_S...

SEN / CTL

O95302

Peptidyl-prolyl cis-trans isomerase FKBP9

FKBP9

2.25

0.93

0.0792

0.0428

protein peptidyl-prolyl isomerization,protein fold...

peptidyl-prolyl cis-trans isomerase activity,calci...

cytoplasm,endoplasmic reticulum,endoplasmic reticu...

6

24

29

_ISQSGDFLR_.2|_FVPDEC[+57]PR_.2|_TIQVSDFVR_.2|_VVP...

SEN / CTL

Q96AY3

Peptidyl-prolyl cis-trans isomerase FKBP10

FKBP10

2.2

0.25

2.53e-8

5.17e-8

protein peptidyl-prolyl isomerization,chaperone-me...

peptidyl-prolyl cis-trans isomerase activity,calci...

cytoplasm,endoplasmic reticulum lumen,endoplasmic ...

15

34

53

_GGTYDTYVGSGWLIK_.2|_IIIPPFLAYGEK_.2|_LMPGQDPEK_.2...

SEN / CTL

Q16851

UTP--glucose-1-phosphate uridylyltransferase

UGP2

2.11

1.37

0.0243

0.0153

glycogen metabolic process,glycogen biosynthetic p...

UTP:glucose-1-phosphate uridylyltransferase activi...

nucleus,cytoplasm,cytosol,extracellular exosome

10

37

59

_EFPTVPLVK_.2|_LVEIAQVPK_.2|_GLPDNISSVLNK_.2|_IYTF...

SEN / CTL

P51858

Hepatoma-derived growth factor

HDGF

2.08

0.41

0.0000516

0.0000621

negative regulation of transcription from RNA poly...

nucleotide binding,RNA polymerase II transcription...

extracellular space,nucleoplasm,cytoplasm,transcri...

12

29

48

_KGFSEGLWEIENNPTVK_.3|_KGFSEGLWEIENNPTVK_.2|_C[+57...

SEN / CTL

Q8WX93

Palladin

PALLD

2.05

0.2

0.0764

0.0415

keratinocyte development,epithelial cell morphogen...

actin binding,protein binding,muscle alpha-actinin...

ruffle,podosome,nucleus,cytosol,actin filament,pla...

6

44

58

_NEAGIVSC[+57]TAR_.2|_LQNTGVADGYPVRLEC[+57]R_.3|_Y...

SEN / CTL

P07910

Heterogeneous nuclear ribonucleoproteins C1/C2

HNRNPC

1.97

0.78

9.73e-7

0.00000154

mRNA splicing, via spliceosome,osteoblast differen...

nucleotide binding,RNA polymerase II core promoter...

nuclear chromatin,nucleus,nucleoplasm,spliceosomal...

26

30

47

_VPPPPPIAR_.2|_KSDVEAIFSK_.2|_MYSYPAR_.2|_SDVEAIFS...

SEN / CTL

Q13283

Ras GTPase-activating protein-binding protein 1

G3BP1

1.94

0.03

0.00205

0.00178

transport,Ras protein signal transduction,DNA dupl...

DNA binding,RNA binding,mRNA binding,ATP-dependent...

nucleus,cytosol,plasma membrane,focal adhesion,cyt...

3

27

59

_INSGGKLPNFGFVVFDDSEPVQK_.3|_INSGGKLPNFGFVVFDDSEPV...

SEN / CTL

O00410

Importin-5

IPO5

1.93

0.57

0.00929

0.0067

protein import into nucleus, translocation,NLS-bea...

RNA binding,GTPase inhibitor activity,protein bind...

nucleus,nuclear pore,nucleolus,cytoplasm,membrane,...

9

61

119

_SLVEIADTVPK_.2|_VC[+57]DIAAELAR_.2|_ITFLLQAIR_.2|...

SEN / CTL

P32119

Peroxiredoxin-2

PRDX2

1.93

1.73

0.0314

0.0192

response to reactive oxygen species,response to ox...

thioredoxin peroxidase activity,antioxidant activi...

cytoplasm,cytosol,extracellular exosome

24

24

40

_GLFIIDGK_.2|_ATAVVDGAFKEVK_.3|_ATAVVDGAFKEVK_.2|_...

SEN / CTL

Q13347

Eukaryotic translation initiation factor 3 subunit I

EIF3I

1.87

0.28

0.013

0.00899

translational initiation,formation of translation ...

translation initiation factor activity,protein bin...

cytosol,eukaryotic translation initiation factor 3...

7

28

48

_SYSSGGEDGYVR_.2|_QINDIQLSR_.2|_SGEVLVNVK_.2|_LWDC...

SEN / CTL

P33316

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

DUT

1.86

0.21

0.000825

0.000786

nucleobase-containing compound metabolic process,d...

RNA binding,dUTP diphosphatase activity,protein bi...

nucleus,nucleoplasm,mitochondrion,extracellular ex...

5

17

27

_IAQLIC[+57]ER_.2|_TDIQIALPSGC[+57]YGR_.2|_TDIQIAL...

SEN / CTL

O60701

UDP-glucose 6-dehydrogenase

UGDH

1.85

0.44

0.000506

0.000501

gastrulation with mouth forming second,UDP-glucose...

UDP-glucose 6-dehydrogenase activity,electron carr...

nucleoplasm,cytosol,extracellular exosome,nucleus

14

46

76

_LAANAFLAQR_.2|_VTVVDVNESR_.2|_ILTTNTWSSELSK_.2|_V...

SEN / CTL

Q12805

EGF-containing fibulin-like extracellular matrix protein 1

EFEMP1

1.85

0.19

0.0151

0.0103

regulation of transcription, DNA-templated,epiderm...

epidermal growth factor-activated receptor activit...

extracellular region,proteinaceous extracellular m...

7

16

18

_ADQVC[+57]INLR_.2|_NPC[+57]QDPYILTPENR_.2|_GSFAC[...

SEN / CTL

Q15436

Protein transport protein Sec23A

SEC23A

1.84

0.08

0.0399

0.0237

antigen processing and presentation of peptide ant...

protein binding,zinc ion binding

Golgi membrane,endoplasmic reticulum,endoplasmic r...

2

36

56

_FSWNVWPSSR_.2|_LAIYRAETEEGPDVLR_.3|_QLQEMLGLSK_.2...

SEN / CTL

O15347

High mobility group protein B3

HMGB3

1.83

0.26

0.0927

0.0486

DNA recombination,transcription, DNA-templated,reg...

four-way junction DNA binding,double-stranded DNA ...

nucleus,chromosome,cytoplasm

2

15

26

_STNPGISIGDVAK_.2|_M[+16]SAYAFFVQTC[+57]R_.2|_MSAY...

SEN / CTL

P61978

Heterogeneous nuclear ribonucleoprotein K

HNRNPK

1.82

0.87

6.33e-12

1.74e-11

mRNA splicing, via spliceosome,transcription from ...

RNA polymerase II core promoter proximal region se...

nuclear chromatin,podosome,nucleus,nucleoplasm,cyt...

61

41

76

_DLAGSIIGK_.2|_GSDFDC[+57]ELR_.2|_IILDLISESPIKGR_....

SEN / CTL

Q16555

Dihydropyrimidinase-related protein 2

DPYSL2

1.78

0.55

2.48e-12

7.21e-12

nucleobase-containing compound metabolic process,e...

dihydropyrimidinase activity,protein binding,micro...

cytosol,plasma membrane,extracellular exosome,micr...

36

34

71

_GSPLVVISQGK_.2|_SSAEVIAQAR_.2|_VFNLYPR_.2|_QIGENL...

SEN / CTL

O14818

Proteasome subunit alpha type-7

PSMA7

1.77

1.15

0.0084

0.00615

MAPK cascade,protein polyubiquitination,stimulator...

threonine-type endopeptidase activity,protein bind...

proteasome complex,nucleus,nucleoplasm,cytosol,pro...

13

16

28

_GRDIVVLGVEKK_.3|_LTVEDPVTVEYITR_.2|_LTVEDPVTVEYIT...

SEN / CTL

P12004

Proliferating cell nuclear antigen

PCNA

1.74

0.85

0.0000163

0.0000213

G1/S transition of mitotic cell cycle,regulation o...

purine-specific mismatch base pair DNA N-glycosyla...

nuclear chromosome, telomeric region,nucleus,nucle...

24

21

41

_DLSHIGDAVVISC[+57]AK_.3|_DLSHIGDAVVISC[+57]AK_.2|...

SEN / CTL

Q86V81

THO complex subunit 4

ALYREF

1.68

0.33

0.00877

0.00639

regulation of DNA recombination,mRNA splicing, via...

nucleotide binding,RNA binding,protein binding,pol...

transcription export complex,nucleoplasm,cytosol,m...

4

12

20

_SLGTADVHFER_.3|_SLGTADVHFER_.2|_QQLSAEELDAQLDAYNA...

SEN / CTL

P14324

Farnesyl pyrophosphate synthase

FDPS

1.66

0.01

0.0156

0.0105

cholesterol biosynthetic process,viral process,ger...

RNA binding,dimethylallyltranstransferase activity...

nucleoplasm,cytoplasm,cytosol

2

17

27

_IGTDIQDNK_.2|_ATPEQYQILK_.2|_C[+57]SWLVVQC[+57]LQ...

SEN / CTL

P49327

Fatty acid synthase

FASN

1.65

1.21

0.00131

0.00121

osteoblast differentiation,acetyl-CoA metabolic pr...

RNA binding,fatty acid synthase activity,[acyl-car...

mitochondrion,Golgi apparatus,cytosol,plasma membr...

23

162

312

_GTPLISPLIK_.2|_QEPLLIGSTK_.2|_GLVQALQTK_.2|_TGTVS...

SEN / CTL

P34932

Heat shock 70 kDa protein 4

HSPA4

1.64

0.52

0.000316

0.000328

response to unfolded protein,protein import into m...

protein binding,ATP binding

cytosol,extracellular exosome

21

84

155

_AGGIETIANEYSDR_.2|_AGGIETIANEYSDR_.3|_C[+57]TPAC[...

SEN / CTL

P00540

Proto-oncogene serine/threonine-protein kinase mos

MOS

1.64

2.18

0.00707

0.0053

MAPK cascade,activation of MAPKK activity,activati...

protein serine/threonine kinase activity,MAP kinas...

cytoplasm,intracellular

10

8

8

_LLLGATLPR_.2|_TGGQLSLGK_.2|_LGAGGFGSVYK_.2|_LLLVD...

SEN / CTL

P53396

ATP-citrate synthase

ACLY

1.62

1.25

0.024

0.0152

acetyl-CoA biosynthetic process,citrate metabolic ...

ATP citrate synthase activity,protein binding,ATP ...

extracellular region,nucleoplasm,cytosol,plasma me...

26

85

146

_LGQEATVGK_.2|_STTLFSR_.2|_EAGVFVPR_.2|_YQDTPGVK_....

SEN / CTL

Q7KZF4

Staphylococcal nuclease domain-containing protein 1

SND1

1.61

0.34

0.00143

0.00129

osteoblast differentiation,transcription, DNA-temp...

transcription cofactor activity,RNA binding,nuclea...

nucleus,cytoplasm,mitochondrion,cytosol,membrane,R...

16

71

115

_FVDGEWYR_.2|_LGTLSPAFSTR_.2|_VADISGDTQK_.2|_QINLS...

SEN / CTL

P25786

Proteasome subunit alpha type-1

PSMA1

1.61

0.64

0.00144

0.00129

MAPK cascade,protein polyubiquitination,stimulator...

RNA binding,threonine-type endopeptidase activity,...

proteasome complex,nucleus,nucleoplasm,centrosome,...

16

25

45

_LVSLIGSK_.2|_NVSIGIVGK_.2|_FVFDRPLPVSR_.3|_ALRETL...

SEN / CTL

A8MWD9 P62308

Putative small nuclear ribonucleoprotein G-like protein 15;Small nuclear ribonucleoprotein G

SNRPGP15 SNRPG

1.57

0.2

0.0701

0.0384

spliceosomal snRNP assembly,mRNA splicing, via spl...

RNA binding;RNA binding,protein binding,poly(A) RN...

U5 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,U12-type splic...

2

3

5

_GNSIIMLEALERV_.2|_GNSIIM[+16]LEALERV_.2|_HVQGILR_...

SEN / CTL

P55145

Mesencephalic astrocyte-derived neurotrophic factor

MANF

1.56

0.09

0.0000126

0.0000167

platelet degranulation,response to unfolded protei...

RNA binding,growth factor activity,poly(A) RNA bin...

extracellular region,extracellular space,nucleus,e...

6

16

22

_QIDLSTVDLK_.2|_LC[+57]YYIGATDDAATK_.2|_LC[+57]YYI...

SEN / CTL

P30048

Thioredoxin-dependent peroxide reductase, mitochondrial

PRDX3

1.55

0.21

2.62e-8

5.32e-8

response to reactive oxygen species,maternal place...

protein binding,protein C-terminus binding,thiored...

cytoplasm,mitochondrion,mitochondrial matrix,early...

19

19

41

_SVEETLR_.2|_GLFIIDPNGVIK_.2|_HLSVNDLPVGR_.3|_HLSV...

SEN / CTL

P16401

Histone H1.5

HIST1H1B

1.54

1.83

0.00587

0.00455

negative regulation of transcription from RNA poly...

RNA binding,chromatin DNA binding,histone deacetyl...

nucleosome,nuclear chromatin,nuclear heterochromat...

30

13

17

_ALAAGGYDVEKNNSR_.3|_KATGPPVSELITK_.3|_KATGPPVSELI...

SEN / CTL

P15121

Aldose reductase

AKR1B1

1.53

1.76

0.0339

0.0206

tissue homeostasis,renal water homeostasis,carbohy...

alditol:NADP+ 1-oxidoreductase activity,aldo-keto ...

extracellular space,nucleoplasm,cytosol,cell proje...

22

26

42

_VAIDVGYR_.2|_TTAQVLIR_.2|_LIQYC[+57]QSK_.2|_SPPGQ...

SEN / CTL

P25398

40S ribosomal protein S12

RPS12

1.52

0.89

0.00000172

0.00000258

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleoplasm,cytosol,membrane,cytosolic small ribos...

36

13

28

_TALIHDGLAR_.2|_LGEWVGLC[+57]K_.2|_LGEWVGLC[+57]K_...

SEN / CTL

P04908 Q7L7L0 Q93077

Histone H2A type 1-B/E;Histone H2A type 3;Histone H2A type 1-C

HIST1H2AB HIST3H2A HIST1H2AC

1.5

0.5

9.57e-15

3.68e-14

chromatin silencing,negative regulation of cell pr...

DNA binding,protein heterodimerization activity;DN...

nucleosome,nuclear chromatin,nucleus,extracellular...

29

6

13

_AGLQFPVGR_.2|_VTIAQGGVLPNIQAVLLPK_.2|_VTIAQGGVLPN...

SEN / CTL

P06748

Nucleophosmin

NPM1

1.5

1.72

5.33e-8

1.04e-7

DNA repair,nucleosome assembly,regulation of trans...

transcription coactivator activity,RNA binding,pro...

nucleus,nucleoplasm,nucleolus,cytoplasm,centrosome...

58

26

61

_GPSSVEDIK_.2|_GPSSVEDIKAK_.2|_MQASIEK_.2|_M[+16]Q...

SEN / CTL

Q14103

Heterogeneous nuclear ribonucleoprotein D0

HNRNPD

1.5

0.67

0.00000147

0.00000224

mRNA splicing, via spliceosome,telomere maintenanc...

nucleotide binding,AT DNA binding,chromatin bindin...

nucleus,nucleoplasm,cytosol,intracellular ribonucl...

22

25

51

_FGEVVDC[+57]TLK_.2|_IFVGGLSPDTPEEK_.2|_IFVGGLSPDT...

SEN / CTL

P10412 P16402

Histone H1.4;Histone H1.3

HIST1H1E HIST1H1D

1.48

1.07

6.28e-8

1.2e-7

negative regulation of transcription from RNA poly...

RNA binding,protein binding,chromatin DNA binding,...

nucleosome,nucleus,nuclear heterochromatin,extrace...

39

13

21

_KASGPPVSELITK_.3|_KASGPPVSELITK_.2|_ALAAAGYDVEKNN...

SEN / CTL

P27816

Microtubule-associated protein 4

MAP4

1.48

0.73

0.000175

0.000188

mitotic spindle organization,neuron projection dev...

RNA binding,structural molecule activity,protein b...

cytoplasm,microtubule,microtubule associated compl...

24

68

96

_SPSTLLPK_.2|_VGSLDNVGHLPAGGAVK_.3|_VGSLDNVGHLPAGG...

SEN / CTL

P49588

Alanine--tRNA ligase, cytoplasmic

AARS

1.44

0.15

0.0374

0.0225

hair follicle development,tRNA modification,tRNA a...

tRNA binding,aminoacyl-tRNA editing activity,alani...

cytoplasm,cytosol,membrane,extracellular exosome,m...

4

62

112

_LVSVLQNK_.2|_IVAVTGAEAQK_.2|_AVYTQDC[+57]PLAAAK_....

SEN / CTL

P02545

Prelamin-A/C

LMNA

1.43

0.94

1e-72

3.34e-71

mitotic nuclear envelope disassembly,mitotic nucle...

structural molecule activity,protein binding

nucleus,nuclear envelope,lamin filament,nucleoplas...

250

85

142

_SLETENAGLR_.2|_LADALQELR_.2|_EGDLIAAQAR_.2|_LQLEL...

SEN / CTL

Q02790

Peptidyl-prolyl cis-trans isomerase FKBP4

FKBP4

1.43

0.85

0.0417

0.0244

protein peptidyl-prolyl isomerization,protein fold...

RNA binding,peptidyl-prolyl cis-trans isomerase ac...

nucleoplasm,cytoplasm,mitochondrion,cytosol,microt...

21

58

112

_TQLAVC[+57]QQR_.2|_VLQLYPNNK_.2|_LQAFSAAIESC[+57]...

SEN / CTL

P23526

Adenosylhomocysteinase

AHCY

1.42

0.2

0.00457

0.00363

sulfur amino acid metabolic process,response to hy...

adenosylhomocysteinase activity,protein binding,ad...

nucleus,cytosol,melanosome,neuron projection,extra...

16

34

62

_AGIPVYAWK_.2|_VADIGLAAWGR_.2|_IILLAEGR_.2|_VAVVAG...

SEN / CTL

P06899 P23527 P33778 Q16778

Histone H2B type 1-J;Histone H2B type 1-O;Histone H2B type 1-B;Histone H2B type 2-E

HIST1H2BJ HIST1H2BO HIST1H2BB HIST2H2BE

1.4

1.64

0.00000878

0.0000119

innate immune response in mucosa,nucleosome assemb...

DNA binding,protein heterodimerization activity;DN...

nucleosome,extracellular space,nucleus,nucleoplasm...

41

8

16

_LLLPGELAK_.2|_QVHPDTGISSK_.2|_ESYSIYVYK_.2|_AMGIM...

SEN / CTL

Q15717

ELAV-like protein 1

ELAVL1

1.4

0.18

0.00625

0.0048

mRNA splicing, via spliceosome,multicellular organ...

nucleotide binding,RNA binding,double-stranded RNA...

nucleus,nucleoplasm,cytoplasm,cytosol,membrane,rib...

4

21

35

_VLVDQTTGLSR_.2|_SLFSSIGEVESAK_.2|_SLFSSIGEVESAK_....

SEN / CTL

P48444

Coatomer subunit delta

ARCN1

1.4

0.43

0.0388

0.0231

intracellular protein transport,ER to Golgi vesicl...

RNA binding,poly(A) RNA binding

Golgi membrane,endoplasmic reticulum membrane,cyto...

15

40

66

_ITLTC[+57]GR_.2|_VTQVDGNSPVR_.2|_SFPVNSDVGVLK_.2|...

SEN / CTL

O95782

AP-2 complex subunit alpha-1

AP2A1

1.4

0.58

0.0513

0.0292

intracellular protein transport,Golgi to endosome ...

protein binding,protein C-terminus binding,protein...

cytosol,plasma membrane,membrane,basolateral plasm...

9

48

68

_NADVELQQR_.2|_ALQVGC[+57]LLR_.2|_GLAVFISDIR_.2|_Q...

SEN / CTL

O00148

ATP-dependent RNA helicase DDX39A

DDX39A

1.38

0.16

0.0429

0.025

mRNA splicing, via spliceosome,termination of RNA ...

RNA binding,ATP-dependent RNA helicase activity,pr...

nucleus,nucleoplasm,spliceosomal complex,membrane,...

2

28

52

_DVQEIFR_.2|_ILVATNLFGR_.2|_GSYVSIHSSGFR_.3|_GSYVS...

SEN / CTL

Q12840

Kinesin heavy chain isoform 5A

KIF5A

1.38

0.46

0.09

0.0477

retrograde vesicle-mediated transport, Golgi to ER...

motor activity,protein binding,ATP binding,microtu...

cytosol,kinesin complex,microtubule,membrane,dendr...

4

40

50

_LYLVDLAGSEK_.2|_TGAEGAVLDEAK_.2|_STLMFGQR_.2|_ILQ...

SEN / CTL

P37837

Transaldolase

TALDO1

1.37

1.06

2.99e-7

5.15e-7

carbohydrate metabolic process,xylulose biosynthet...

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosp...

nucleus,cytoplasm,cytosol,extracellular exosome

36

31

43

_SYEPLEDPGVK_.2|_VSTEVDAR_.2|_AAQASDLEK_.2|_LLGELL...

SEN / CTL

P55060

Exportin-2

CSE1L

1.37

1.2

0.00341

0.00285

protein export from nucleus,apoptotic process,cell...

nuclear export signal receptor activity,protein bi...

nucleus,nucleoplasm,cytoplasm,cytosol,membrane,ext...

9

60

93

_IIIPEIQK_.2|_VIVPNMEFR_.2|_VIVPNM[+16]EFR_.2|_VC[...

SEN / CTL

P04080

Cystatin-B

CSTB

1.36

1.63

0.0706

0.0386

adult locomotory behavior,negative regulation of p...

protease binding,RNA binding,endopeptidase inhibit...

extracellular region,extracellular space,nucleolus...

12

8

11

_SQVVAGTNYFIK_.2|_SQVVAGTNYFIK_.3|_VHVGDEDFVHLR_.3...

SEN / CTL

P19338

Nucleolin

NCL

1.33

0.85

8.26e-10

1.95e-9

angiogenesis,positive regulation of transcription ...

nucleotide binding,RNA binding,protein binding,pro...

nucleus,nucleoplasm,nucleolus,cell cortex,membrane...

55

63

97

_NDLAVVDVR_.2|_TGISDVFAK_.2|_NSTWSGESK_.2|_SISLYYT...

SEN / CTL

P07585

Decorin

DCN

1.32

1.32

4.1e-12

1.16e-11

kidney development,placenta development,negative r...

RNA binding,protein kinase inhibitor activity,prot...

extracellular region,proteinaceous extracellular m...

95

22

33

_VSPGAFTPLVK_.2|_VSPGAFTPLVKLER_.3|_NLHALILVNNK_.3...

SEN / CTL

O60814 P57053 P58876 P62807 Q5QNW6 Q93079 Q99877 Q99879 Q99880

Histone H2B type 1-K;Histone H2B type F-S;Histone H2B type 1-D;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-F;Histone H2B type 1-H;Histone H2B type 1-N;Histone H2B type 1-M;Histone H2B type 1-L

HIST1H2BK H2BFS HIST1H2BD HIST1H2BC HIST2H2BF HIST1H2BH HIST1H2BN HIST1H2BM HIST1H2BL

1.31

0.84

0.00000468

0.00000675

innate immune response in mucosa,nucleosome assemb...

molecular_function,DNA binding,protein heterodimer...

nucleosome,extracellular space,nucleus,nucleoplasm...

19

3

4

_ESYSVYVYK_.2|_KESYSVYVYK_.3|_KESYSVYVYK_.2|_SRKES...

SEN / CTL

P52209

6-phosphogluconate dehydrogenase, decarboxylating

PGD

1.31

0.41

0.026

0.0163

pentose-phosphate shunt,pentose-phosphate shunt, o...

phosphogluconate dehydrogenase (decarboxylating) a...

nucleus,cytosol,extracellular exosome

13

36

73

_TIFQGIAAK_.2|_AGQAVDDFIEK_.2|_GILFVGSGVSGGEEGAR_....

SEN / CTL

P50454

Serpin H1

SERPINH1

1.29

0.79

2.25e-27

1.69e-26

chondrocyte development involved in endochondral b...

RNA binding,serine-type endopeptidase inhibitor ac...

endoplasmic reticulum,endoplasmic reticulum lumen,...

102

33

71

_AVLSAEQLRDEEVHAGLGELLR_.4|_AVLSAEQLRDEEVHAGLGELLR...

SEN / CTL

P46821

Microtubule-associated protein 1B

MAP1B

1.29

0.63

0.0518

0.0294

microtubule bundle formation,cellular process,dend...

structural molecule activity,protein binding,micro...

photoreceptor outer segment,cytosol,microtubule,mi...

23

110

158

_GAESPFEEK_.2|_FSPEVPGQK_.2|_AVLDALLEGK_.2|_LSKPC[...

SEN / CTL

P62318

Small nuclear ribonucleoprotein Sm D3

SNRPD3

1.27

0.71

0.00142

0.00129

spliceosomal complex assembly,spliceosomal snRNP a...

RNA binding,protein binding,enzyme binding,U2 snRN...

commitment complex,nucleoplasm,spliceosomal comple...

10

6

8

_VAQLEQVYIR_.2|_FLILPDMLK_.2|_FLILPDM[+16]LK_.2|_V...

SEN / CTL

P51884

Lumican

LUM

1.25

1.04

1.21e-7

2.19e-7

visual perception,response to organic cyclic compo...

extracellular matrix structural constituent,protei...

extracellular region,proteinaceous extracellular m...

60

21

29

_ILGPLSYSK_.2|_SVPMVPPGIK_.2|_FNALQYLR_.2|_LKEDAVS...

SEN / CTL

P38646

Stress-70 protein, mitochondrial

HSPA9

1.25

1.79

0.0488

0.0279

protein folding,protein export from nucleus,erythr...

RNA binding,protein binding,ATP binding,ubiquitin ...

nucleolus,cytoplasm,mitochondrion,focal adhesion,e...

37

68

123

_VLENAEGAR_.2|_DAGQISGLNVLR_.2|_DAGQISGLNVLR_.3|_T...

SEN / CTL

Q01105

Protein SET

SET

1.24

0.43

0.00000118

0.00000181

DNA replication,nucleosome assembly,nucleosome dis...

DNA binding,protein phosphatase inhibitor activity...

nucleus,nucleoplasm,cytoplasm,endoplasmic reticulu...

19

18

30

_VEVTEFEDIK_.2|_EFHLNESGDPSSK_.3|_EFHLNESGDPSSK_.2...

SEN / CTL

P40926

Malate dehydrogenase, mitochondrial

MDH2

1.23

1.49

0.0000198

0.0000257

gluconeogenesis,tricarboxylic acid cycle,oxaloacet...

RNA binding,L-malate dehydrogenase activity,protei...

nucleus,mitochondrion,mitochondrial inner membrane...

48

31

62

_ANTFVAELK_.2|_IQEAGTEVVK_.2|_GYLGPEQLPDC[+57]LKGC...

SEN / CTL

O00115

Deoxyribonuclease-2-alpha

DNASE2

1.23

0.27

0.0019

0.00167

DNA metabolic process,apoptotic DNA fragmentation,...

DNA binding,deoxyribonuclease II activity

intracellular,lysosome,extracellular exosome

5

6

6

_ALINSPEGAVGR_.2|_GPWTC[+57]VGDMNR_.2|_AFQPLVK_.2|...

SEN / CTL

Q9UL46

Proteasome activator complex subunit 2

PSME2

1.22

0.44

0.0167

0.0112

MAPK cascade,protein polyubiquitination,stimulator...

protein binding,identical protein binding,endopept...

proteasome complex,nucleoplasm,cytoplasm,cytosol,p...

6

23

36

_AMVLDLR_.2|_AM[+16]VLDLR_.2|_ALVHERDEAAYGELR_.4|_...

SEN / CTL

P06493

Cyclin-dependent kinase 1

CDK1

1.22

1.09

0.0337

0.0206

G1/S transition of mitotic cell cycle,regulation o...

chromatin binding,protein kinase activity,protein ...

cyclin-dependent protein kinase holoenzyme complex...

8

21

36

_LADFGLAR_.2|_IGEGTYGVVYK_.2|_SPEVLLGSAR_.2|_TTGQV...

SEN / CTL

Q16881

Thioredoxin reductase 1, cytoplasmic

TXNRD1

1.19

0.4

0.0000035

0.00000512

response to reactive oxygen species,response to ox...

thioredoxin-disulfide reductase activity,protein b...

fibrillar center,nucleoplasm,mitochondrion,cytosol...

25

37

60

_LYAGSTVK_.2|_QFVPIKVEQIEAGTPGR_.3|_YLGIPGDKEYC[+5...

SEN / CTL

P00441

Superoxide dismutase [Cu-Zn]

SOD1

1.17

0.9

0.000321

0.000332

activation of MAPK activity,response to reactive o...

superoxide dismutase activity,copper ion binding,p...

extracellular region,extracellular space,nucleus,n...

51

20

39

_LAC[+57]GVIGIAQ_.2|_ADDLGKGGNEESTK_.3|_ADDLGKGGNE...

SEN / CTL

P28070

Proteasome subunit beta type-4

PSMB4

1.16

0.38

0.00387

0.00318

MAPK cascade,protein polyubiquitination,stimulator...

lipopolysaccharide binding,threonine-type endopept...

proteasome complex,nucleus,nucleoplasm,cytosol,pro...

12

10

21

_FQIATVTEK_.2|_QPVLSQTEAR_.2|_EVLEKQPVLSQTEAR_.3|_...

SEN / CTL

P02462

Collagen alpha-1(IV) chain

COL4A1

1.15

1.45

0.0252

0.0159

patterning of blood vessels,brain development,neur...

extracellular matrix structural constituent,protei...

extracellular region,collagen type IV trimer,basem...

31

7

11

_HSQTIDDPQC[+57]PSGTK_.3|_HSQTIDDPQC[+57]PSGTK_.2|...

SEN / CTL

Q14195

Dihydropyrimidinase-related protein 3

DPYSL3

1.12

1.07

0.00127

0.00117

positive regulation of neuron projection developme...

protein binding,hydrolase activity, acting on carb...

extracellular space,cytosol,lamellipodium,growth c...

38

28

42

_GAPLVVIC[+57]QGK_.2|_SAADLISQAR_.2|_IFNLYPR_.2|_Q...

SEN / CTL

P56537

Eukaryotic translation initiation factor 6

EIF6

1.08

1.28

0.0405

0.024

ribosomal subunit export from nucleus,maturation o...

translation initiation factor activity,protein bin...

nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,pr...

16

13

23

_NSLPDTVQIR_.2|_HGLLVPNNTTDQELQHIR_.4|_HGLLVPNNTTD...

SEN / CTL

Q01813

ATP-dependent 6-phosphofructokinase, platelet type

PFKP

1.05

0.36

0.0153

0.0103

fructose 6-phosphate metabolic process,canonical g...

6-phosphofructokinase activity,ATP binding,protein...

nucleus,cytoplasm,cytosol,membrane,extracellular m...

5

55

92

_GGTPSAFDR_.2|_NVIFQPVAELK_.2|_EWSGLLEELAR_.2|_VTI...

SEN / CTL

P07951

Tropomyosin beta chain

TPM2

1.04

0.75

1.29e-8

2.69e-8

muscle contraction,actin filament organization,mus...

actin binding,structural constituent of muscle,act...

cytosol,muscle thin filament tropomyosin,actin fil...

59

29

46

_AMKDEEKMELQEMQLK_.4|_AMKDEEKMELQEMQLK_.3|_KLVILEG...

SEN / CTL

P20962

Parathymosin

PTMS

1.04

0.79

4.21e-7

7.06e-7

immune system process,DNA replication

zinc ion binding

nucleus,cytosol

23

5

8

_SVEAAAELSAK_.2|_AAEEEDEADPKR_.3|_AAEEEDEADPKR_.2|...

SEN / CTL

Q9P2E9

Ribosome-binding protein 1

RRBP1

1.03

0.96

0.000548

0.000541

osteoblast differentiation,translation,protein tra...

RNA binding,receptor activity,poly(A) RNA binding

endoplasmic reticulum,ribosome,membrane,integral c...

11

99

145

_EQEITAVQAR_.2|_LLATEQEDAAVAK_.2|_DALNQATSQVESK_.2...

SEN / CTL

P22314

Ubiquitin-like modifier-activating enzyme 1

UBA1

1.01

1.16

0.000134

0.000148

cellular response to DNA damage stimulus,protein u...

RNA binding,ubiquitin activating enzyme activity,p...

nucleus,nucleoplasm,cytoplasm,mitochondrion,cytoso...

56

67

128

_LQTSSVLVSGLR_.2|_NIILGGVK_.2|_LAGTQPLEVLEAVQR_.2|...

SEN / CTL

P26641

Elongation factor 1-gamma

EEF1G

1.01

1.34

0.0205

0.0133

translational elongation,response to virus,glutath...

translation elongation factor activity,protein bin...

nucleus,cytoplasm,cytosol,membrane,extracellular e...

38

36

59

_KLDPGSEETQTLVR_.3|_KLDPGSEETQTLVR_.2|_STFVLDEFKR_...

SEN / CTL

Q9Y2Z9

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

COQ6

1.01

1.24

0.0235

0.015

ubiquinone biosynthetic process,oxidation-reductio...

oxidoreductase activity, acting on paired donors, ...

mitochondrion,mitochondrial inner membrane,Golgi a...

8

15

21

_ILLLEAGPK_.2|_LLIGADGHNSGVR_.3|_HNTALLAATDLLK_.3|...

SEN / CTL

O60506

Heterogeneous nuclear ribonucleoprotein Q

SYNCRIP

1

1.54

0.0936

0.049

mRNA splicing, via spliceosome,osteoblast differen...

nucleotide binding,RNA binding,protein binding,pol...

nucleus,nucleoplasm,endoplasmic reticulum,membrane...

34

48

77

_LFVGSIPK_.2|_AGPIWDLR_.2|_GYAFVTFC[+57]TK_.2|_TGY...

SEN / CTL

P05388 Q8NHW5

60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like

RPLP0 RPLP0P6

0.99

0.78

0.0272

0.0169

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytoplasm,endoplasmic reticulum,cytosol,fo...

28

6

11

_IIQLLDDYPK_.2|_C[+57]FIVGADNVGSK_.2|_AGAIAPC[+57]...

SEN / CTL

P11940

Polyadenylate-binding protein 1

PABPC1

0.98

1.43

0.000382

0.00039

nuclear-transcribed mRNA catabolic process, nonsen...

nucleotide binding,RNA binding,mRNA 3'-UTR binding...

nucleus,cytoplasm,cytosol,focal adhesion,cytoplasm...

47

45

81

_FSPAGPILSIR_.2|_IVATKPLYVALAQR_.3|_IVATKPLYVALAQR...

SEN / CTL

P68431

Histone H3.1

HIST1H3A

0.97

0.73

8.81e-7

0.00000142

chromatin silencing at rDNA,chromatin organization...

DNA binding,protein binding,histone binding,cadher...

nuclear chromosome,nuclear chromosome, telomeric r...

27

15

24

_STELLIR_.2|_EIAQDFKTDLR_.3|_EIAQDFKTDLR_.2|_EIAQD...

SEN / CTL

P09972

Fructose-bisphosphate aldolase C

ALDOC

0.96

1.6

0.0462

0.0266

fructose metabolic process,gluconeogenesis,fructos...

fructose-bisphosphate aldolase activity,protein bi...

extracellular region,mitochondrion,cytosol,cytoske...

32

27

42

_VDKGVVPLAGTDGETTTQGLDGLSER_.3|_VDKGVVPLAGTDGETTTQ...

SEN / CTL

Q06323

Proteasome activator complex subunit 1

PSME1

0.95

1.54

0.0405

0.024

MAPK cascade,protein polyubiquitination,stimulator...

protein binding,endopeptidase activator activity

proteasome complex,nucleoplasm,cytoplasm,cytosol,p...

13

26

39

_IVVLLQR_.2|_LMVMEIR_.2|_LM[+16]VMEIR_.2|_LMVM[+16...

SEN / CTL

P62805

Histone H4

HIST1H4A

0.93

0.75

0.0000835

0.0000968

chromatin silencing at rDNA,double-strand break re...

DNA binding,RNA binding,protein binding,protein do...

nuclear chromosome,nuclear chromosome, telomeric r...

38

24

44

_DNIQGITKPAIR_.3|_DNIQGITKPAIR_.2|_ISGLIYEETR_.2|_...

SEN / CTL

Q16543

Hsp90 co-chaperone Cdc37

CDC37

0.93

0.59

0.006

0.00464

regulation of cyclin-dependent protein serine/thre...

protein tyrosine kinase activity,protein binding,p...

cytoplasm,cytosol,extracellular exosome,HSP90-CDC3...

34

26

48

_LQAEAQQLR_.2|_LGPGGLDPVEVYESLPEELQK_.3|_LGPGGLDPV...

SEN / CTL

Q01955

Collagen alpha-3(IV) chain

COL4A3

0.92

0.32

0.000337

0.000346

activation of cysteine-type endopeptidase activity...

integrin binding,structural molecule activity,extr...

extracellular region,collagen type IV trimer,basem...

7

1

1

_ASPFLEC[+57]HGR_.2

SEN / CTL

Q8NBS9

Thioredoxin domain-containing protein 5

TXNDC5

0.91

1.79

0.00412

0.00334

protein folding,response to endoplasmic reticulum ...

protein disulfide isomerase activity,protein bindi...

extracellular region,endoplasmic reticulum,endopla...

47

30

49

_FVLSQAKDEL_.2|_IAEVDC[+57]TAER_.2|_GYPTLLLFR_.2|_...

SEN / CTL

P14625

Endoplasmin

HSP90B1

0.89

1.22

1.8e-13

6.06e-13

response to hypoxia,toll-like receptor signaling p...

RNA binding,calcium ion binding,protein binding,AT...

extracellular region,nucleus,endoplasmic reticulum...

115

85

166

_SILFVPTSAPR_.2|_SGYLLPDTK_.2|_EAESSPFVER_.2|_LIIN...

SEN / CTL

P30101

Protein disulfide-isomerase A3

PDIA3

0.88

1.09

6.38e-15

2.52e-14

antigen processing and presentation of peptide ant...

RNA binding,protein disulfide isomerase activity,c...

nucleus,endoplasmic reticulum,endoplasmic reticulu...

154

62

120

_YGVSGYPTLK_.2|_LAPEYEAAATR_.2|_LNFAVASR_.2|_LKGIV...

SEN / CTL

P50395

Rab GDP dissociation inhibitor beta

GDI2

0.88

0.84

1.06e-8

2.25e-8

signal transduction,small GTPase mediated signal t...

RNA binding,Rab GDP-dissociation inhibitor activit...

extracellular region,cytoplasm,Golgi apparatus,cyt...

70

56

113

_LYSESLAR_.2|_FKIPGSPPESMGR_.3|_DLGTESQIFISR_.2|_T...

SEN / CTL

P61158

Actin-related protein 3

ACTR3

0.87

0.49

0.00238

0.00205

movement of cell or subcellular component,establis...

structural constituent of cytoskeleton,protein bin...

cytosol,Arp2/3 protein complex,brush border,cell-c...

51

34

61

_YSYVC[+57]PDLVK_.2|_LGYAGNTEPQFIIPSC[+57]IAIK_.2|...

SEN / CTL

Q8IYT4

Katanin p60 ATPase-containing subunit A-like 2

KATNAL2

0.86

0.59

0.000471

0.000467

cytoplasmic microtubule organization,microtubule s...

protein binding,ATP binding,microtubule-severing A...

nucleus,cytoplasm,microtubule

10

1

1

_GLLLYGPPGTGK_.2

SEN / CTL

P46940

Ras GTPase-activating-like protein IQGAP1

IQGAP1

0.86

0.83

0.0883

0.0469

regulation of cytokine production,signal transduct...

GTPase inhibitor activity,GTPase activator activit...

ruffle,nucleus,cytoplasm,cytosol,microtubule,actin...

28

128

200

_LQQTYAALNSK_.2|_LGNFFSPK_.2|_LIVDVIR_.2|_NKYQELIN...

SEN / CTL

P00736

Complement C1r subcomponent

C1R

0.85

0.86

0.0136

0.00931

proteolysis,immune response,complement activation,...

serine-type endopeptidase activity,calcium ion bin...

extracellular region,extracellular exosome,blood m...

54

25

35

_DYFIATC[+57]K_.2|_NIGEFC[+57]GK_.2|_LPVANPQAC[+57...

SEN / CTL

P49721

Proteasome subunit beta type-2

PSMB2

0.8

0.33

0.0295

0.0182

MAPK cascade,protein polyubiquitination,stimulator...

threonine-type endopeptidase activity,protein bind...

proteasome complex,nucleus,nucleoplasm,cytosol,pro...

4

21

33

_NLADC[+57]LR_.2|_FILNLPTFSVR_.2|_RNLADC[+57]LR_.2...

SEN / CTL

P09871

Complement C1s subcomponent

C1S

0.78

1.74

0.00942

0.00678

complement activation, lectin pathway,proteolysis,...

serine-type endopeptidase activity,calcium ion bin...

extracellular region,extracellular exosome,blood m...

35

27

39

_LLEVPEGR_.2|_TNFDNDIALVR_.2|_SDFSNEER_.2|_YHGDPMP...

SEN / CTL

P16949

Stathmin

STMN1

0.77

0.73

1.08e-9

2.51e-9

mitotic cytokinesis,microtubule depolymerization,m...

signal transducer activity,protein binding,tubulin...

intracellular,cytoplasm,cytosol,microtubule,membra...

62

18

24

_DLSLEEIQK_.2|_AIEENNNFSK_.2|_SHEAEVLK_.2|_SKESVPE...

SEN / CTL

P01031

Complement C5

C5

0.77

0.14

0.0117

0.00818

activation of MAPK activity,in utero embryonic dev...

endopeptidase inhibitor activity,receptor binding,...

extracellular region,membrane attack complex,extra...

3

68

93

_VTC[+57]TNAELVK_.2|_WLSEEQR_.2|_TGEAVAEK_.2|_FSYS...

SEN / CTL

Q04760

Lactoylglutathione lyase

GLO1

0.76

0.99

0.0262

0.0164

carbohydrate metabolic process,pyruvate metabolic ...

lactoylglutathione lyase activity,zinc ion binding

nucleus,cytoplasm,cytosol,plasma membrane,extracel...

37

16

31

_SLDFYTR_.2|_IAWALSR_.2|_RFEELGVK_.2|_VLGMTLIQK_.2...

SEN / CTL

P13667

Protein disulfide-isomerase A4

PDIA4

0.75

0.62

8.46e-14

2.89e-13

protein folding,protein secretion,response to endo...

RNA binding,protein disulfide isomerase activity,p...

endoplasmic reticulum,endoplasmic reticulum lumen,...

86

69

125

_FDVSGYPTIK_.2|_FDVSGYPTLK_.2|_IDATSASVLASR_.2|_VD...

SEN / CTL

P27797

Calreticulin

CALR

0.75

1.06

9.25e-9

2e-8

negative regulation of transcription from RNA poly...

complement component C1q binding,glycoprotein bind...

acrosomal vesicle,extracellular region,proteinaceo...

86

52

95

_FVLSSGK_.1|_EQFLDGDGWTSR_.2|_HEQNIDC[+57]GGGYVK_....

SEN / CTL

P69905

Hemoglobin subunit alpha

HBA1

0.75

0.65

8e-8

1.49e-7

receptor-mediated endocytosis,positive regulation ...

oxygen transporter activity,iron ion binding,prote...

extracellular region,cytosol,hemoglobin complex,me...

45

23

78

_LRVDPVNFK_.2|_MFLSFPTTK_.2|_M[+16]FLSFPTTK_.2|_TY...

SEN / CTL

Q93045

Stathmin-2

STMN2

0.73

0.23

0.0000155

0.0000204

negative regulation of microtubule depolymerizatio...

protein binding,tubulin binding,calcium-dependent ...

cytoplasm,endosome,Golgi apparatus,membrane,lamell...

9

1

1

_ALEENNNFSK_.2

SEN / CTL

P62280

40S ribosomal protein S11

RPS11

0.72

0.67

0.00171

0.00152

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,f...

18

16

23

_ILSGVVTK_.2|_DVQIGDIVTVGEC[+57]RPLSK_.3|_DVQIGDIV...

SEN / CTL

P00338

L-lactate dehydrogenase A chain

LDHA

0.7

0.95

1.7e-11

4.44e-11

response to hypoxia,lactate metabolic process,pyru...

L-lactate dehydrogenase activity,protein binding,k...

nucleus,cytosol,membrane,extracellular exosome,cel...

148

38

92

_LVIITAGAR_.2|_VTLTSEEEAR_.2|_SADTLWGIQK_.2|_DYNVT...

SEN / CTL

Q32P28

Prolyl 3-hydroxylase 1

LEPRE1

0.7

0.41

0.0527

0.0297

protein folding,negative regulation of cell prolif...

molecular_function,iron ion binding,procollagen-pr...

proteinaceous extracellular matrix,endoplasmic ret...

16

29

36

_AVGFSSGTENPHGVK_.3|_TVTAEVQPQC[+57]GR_.2|_TAIEEVQ...

SEN / CTL

Q96TA1

Niban-like protein 1

FAM129B

0.69

0.27

0.00168

0.00151

negative regulation of apoptotic process,cell-cell...

cadherin binding,cadherin binding involved in cell...

nucleoplasm,cytosol,plasma membrane,adherens junct...

6

38

58

_FDVSSTSVFK_.2|_FQELIFEDFAR_.2|_AVINSAGYK_.2|_GPTK...

SEN / CTL

P12814

Alpha-actinin-1

ACTN1

0.67

0.89

1.44e-20

8.31e-20

platelet degranulation,actin filament organization...

double-stranded RNA binding,integrin binding,calci...

stress fiber,ruffle,extracellular region,extracell...

254

94

202

_ALDFIASK_.2|_EGLLLWC[+57]QR_.2|_LAILGIHNEVSK_.3|_...

SEN / CTL

P35609

Alpha-actinin-2

ACTN2

0.67

0.35

0.00102

0.000969

MAPK cascade,platelet degranulation,cell adhesion,...

Ras guanyl-nucleotide exchange factor activity,int...

extracellular region,cytosol,cytoskeleton,actin fi...

11

7

10

_ISNRPAFMPSEGK_.3|_ISNRPAFMPSEGK_.2|_ISNRPAFM[+16]...

SEN / CTL

O14773

Tripeptidyl-peptidase 1

TPP1

0.67

0.61

0.0506

0.0288

proteolysis,lipid metabolic process,lysosome organ...

endopeptidase activity,serine-type endopeptidase a...

mitochondrion,lysosome,melanosome,lysosomal lumen,...

24

16

26

_LFGGNFAHQASVAR_.3|_LFGGNFAHQASVAR_.2|_VNTELMK_.2|...

SEN / CTL

P55072

Transitional endoplasmic reticulum ATPase

VCP

0.66

1.19

1.84e-13

6.14e-13

DNA repair,double-strand break repair,protein fold...

RNA binding,protein binding,ATP binding,lipid bind...

proteasome complex,extracellular region,nucleus,nu...

116

94

187

_GILLYGPPGTGK_.2|_LAGESESNLR_.2|_SVSDNDIR_.2|_LDQL...

SEN / CTL

P40925

Malate dehydrogenase, cytoplasmic

MDH1

0.66

0.47

5.37e-8

1.04e-7

gluconeogenesis,tricarboxylic acid cycle,oxaloacet...

malic enzyme activity,protein binding,L-malate deh...

extracellular space,mitochondrion,cytosol,myelin s...

46

23

39

_LGVTANDVK_.2|_FVEGLPINDFSR_.2|_ENFSC[+57]LTR_.2|_...

SEN / CTL

P04075

Fructose-bisphosphate aldolase A

ALDOA

0.65

0.89

6.62e-37

6.6e-36

platelet degranulation,fructose metabolic process,...

RNA binding,actin binding,fructose-bisphosphate al...

extracellular region,extracellular space,nucleus,c...

303

51

110

_ALQASALK_.2|_ALANSLAC[+57]QGK_.2|_ADDGRPFPQVIK_.3...

SEN / CTL

P04792

Heat shock protein beta-1

HSPB1

0.64

0.83

1.43e-7

2.55e-7

retina homeostasis,regulation of protein phosphory...

RNA binding,protein kinase C binding,protein bindi...

proteasome complex,extracellular space,nucleus,cyt...

92

23

44

_LFDQAFGLPR_.2|_VSLDVNHFAPDELTVK_.3|_VSLDVNHFAPDEL...

SEN / CTL

Q15084

Protein disulfide-isomerase A6

PDIA6

0.63

0.89

1.05e-7

1.92e-7

protein folding,response to endoplasmic reticulum ...

protein disulfide isomerase activity,protein bindi...

endoplasmic reticulum,endoplasmic reticulum lumen,...

68

32

56

_NSYLEVLLK_.2|_AATALKDVVK_.2|_LAAVDATVNQVLASR_.2|_...

SEN / CTL

P14314

Glucosidase 2 subunit beta

PRKCSH

0.63

1.1

0.000259

0.000272

protein folding,N-glycan processing,intracellular ...

protein kinase C binding,calcium ion binding,ion c...

intracellular,endoplasmic reticulum,endoplasmic re...

50

34

64

_LWEEQLAAAK_.2|_NKFEEAER_.2|_SLEDQVEMLR_.2|_SLEDQV...

SEN / CTL

P11021

78 kDa glucose-regulated protein

HSPA5

0.62

0.95

7.55e-23

4.92e-22

ER overload response,activation of signaling prote...

glycoprotein binding,calcium ion binding,protein b...

nucleus,mitochondrion,endoplasmic reticulum,endopl...

294

68

133

_LTPEEIER_.2|_VLEDSDLKKSDIDEIVLVGGSTR_.4|_VLEDSDLK...

SEN / CTL

P24844

Myosin regulatory light polypeptide 9

MYL9

0.62

0.91

0.00662

0.00504

muscle contraction,regulation of muscle contractio...

calcium ion binding,structural constituent of musc...

stress fiber,cytosol,muscle myosin complex,Z disc

10

6

10

_GNFNYVEFTR_.2|_NAFAC[+57]FDEEASGFIHEDHLR_.4|_NAFA...

SEN / CTL

Q99436

Proteasome subunit beta type-7

PSMB7

0.62

0.23

0.0152

0.0103

MAPK cascade,protein polyubiquitination,stimulator...

threonine-type endopeptidase activity,protein bind...

proteasome complex,extracellular region,nucleus,nu...

10

16

33

_GTTAVLTEK_.2|_ATEGMVVADKNC[+57]SK_.3|_ATEGMVVADKN...

SEN / CTL

P62263

40S ribosomal protein S14

RPS14

0.62

1.2

0.0382

0.0229

ribosomal small subunit assembly,negative regulati...

RNA binding,structural constituent of ribosome,pro...

nucleoplasm,nucleolus,mitochondrion,cytosol,focal ...

18

15

31

_TPGPGAQSALR_.2|_IGRIEDVTPIPSDSTRR_.4|_IGRIEDVTPIP...

SEN / CTL

P62191

26S protease regulatory subunit 4

PSMC1

0.62

0.09

0.0799

0.0431

MAPK cascade,protein polyubiquitination,stimulator...

RNA binding,protein binding,ATP binding,ATPase act...

proteasome complex,nucleus,nucleoplasm,cytosol,pro...

3

36

54

_GVILYGPPGTGK_.2|_VVGSELIQK_.2|_AVANQTSATFLR_.2|_A...

SEN / CTL

O43707

Alpha-actinin-4

ACTN4

0.61

1.26

0.0000676

0.0000808

response to hypoxia,platelet degranulation,protein...

RNA polymerase II regulatory region sequence-speci...

stress fiber,extracellular region,extracellular sp...

156

75

147

_VQQLVPK_.2|_ETTDTDTADQVIASFK_.2|_ETTDTDTADQVIASFK...

SEN / CTL

P30050

60S ribosomal protein L12

RPL12

0.6

0.55

0.0959

0.0499

ribosomal large subunit assembly,nuclear-transcrib...

RNA binding,structural constituent of ribosome,pro...

nucleolus,cytosol,focal adhesion,membrane,cytosoli...

16

9

17

_IGPLGLSPK_.2|_C[+57]TGGEVGATSALAPK_.2|_C[+57]TGGE...

SEN / CTL

P14618

Pyruvate kinase PKM

PKM

0.57

1.16

1.16e-17

5.44e-17

programmed cell death,cellular response to insulin...

magnesium ion binding,RNA binding,pyruvate kinase ...

extracellular region,nucleus,cytoplasm,mitochondri...

357

71

161

_APIIAVTR_.2|_GDLGIEIPAEK_.2|_KGVNLPGAAVDLPAVSEKDI...

SEN / CTL

Q92747

Actin-related protein 2/3 complex subunit 1A

ARPC1A

0.57

0.16

0.0869

0.0464

actin cytoskeleton organization,Arp2/3 complex-med...

actin binding,actin filament binding

cytosol,Arp2/3 protein complex,actin cytoskeleton,...

5

22

36

_TLESSIQGLR_.2|_SVQVSTLK_.2|_LAWVSHDSTVSVADASK_.3|...

SEN / CTL

P04004

Vitronectin

VTN

0.56

1.26

0.0207

0.0134

receptor-mediated endocytosis,immune response,cell...

scavenger receptor activity,integrin binding,prote...

extracellular region,basement membrane,extracellul...

19

22

33

_LIRDVWGIEGPIDAAFTR_.3|_DVWGIEGPIDAAFTR_.2|_DVWGIE...

SEN / CTL

P58546

Myotrophin

MTPN

0.56

0.64

0.0384

0.023

regulation of translation,catecholamine metabolic ...

sequence-specific DNA binding

nucleus,cytosol,F-actin capping protein complex,ax...

29

13

27

_GADKTVKGPDGLTAFEATDNQAIK_.4|_GADINAPDKHHITPLLSAVY...

SEN / CTL

P68371

Tubulin beta-4B chain

TUBB4B

0.55

1.07

3.83e-7

6.45e-7

G2/M transition of mitotic cell cycle,movement of ...

double-stranded RNA binding,GTPase activity,struct...

extracellular region,nucleus,cytosol,cytoskeleton,...

297

42

123

_YLTVAAVFR_.2|_IREEYPDR_.2|_INVYYNEATGGKYVPR_.3|_N...

SEN / CTL

Q14847

LIM and SH3 domain protein 1

LASP1

0.55

0.96

0.000116

0.000131

ion transport,positive regulation of signal transd...

SH3/SH2 adaptor activity,protein binding,zinc ion ...

cytoplasm,focal adhesion,cortical actin cytoskelet...

62

20

35

_GKGFSVVADTPELQR_.3|_LKQQSELQSQVR_.3|_LKQQSELQSQVR...

SEN / CTL

P46777

60S ribosomal protein L5

RPL5

0.54

0.94

0.0679

0.0374

ribosomal large subunit assembly,nuclear-transcrib...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleolus,cytoplasm,cytosol,focal adhesion...

59

27

56

_VGLTNYAAAYC[+57]TGLLLAR_.2|_VGLTNYAAAYC[+57]TGLLL...

SEN / CTL

Q15582

Transforming growth factor-beta-induced protein ig-h3

TGFBI

0.53

1.47

4.69e-13

1.53e-12

angiogenesis,chondrocyte differentiation,cell adhe...

integrin binding,protein binding,collagen binding,...

extracellular region,basement membrane,extracellul...

385

38

60

_SPYQLVLQHSR_.3|_SPYQLVLQHSR_.2|_EGVYTVFAPTNEAFR_....

SEN / CTL

P18206

Vinculin

VCL

0.53

0.92

5.83e-13

1.84e-12

morphogenesis of an epithelium,platelet degranulat...

dystroglycan binding,actin binding,structural mole...

podosome,extracellular region,cytosol,cytoskeleton...

207

102

192

_ELTPQVVSAAR_.2|_ALIQC[+57]AK_.2|_IPTISTQLK_.2|_ST...

SEN / CTL

Q13885

Tubulin beta-2A chain

TUBB2A

0.53

0.48

0.0000115

0.0000154

cytoskeleton organization,microtubule-based proces...

GTPase activity,structural constituent of cytoskel...

nucleus,cytoplasm,microtubule,microtubule cytoskel...

35

12

25

_YLTVAAIFR_.2|_AILVDLEPGTMDSVR_.2|_AILVDLEPGTMDSVR...

SEN / CTL

P07195

L-lactate dehydrogenase B chain

LDHB

0.53

0.98

0.00119

0.00111

carbohydrate metabolic process,lactate metabolic p...

L-lactate dehydrogenase activity,protein binding,k...

cytoplasm,mitochondrion,cytosol,membrane,myelin sh...

64

35

73

_IVVVTAGVR_.2|_GLTSVINQK_.2|_IVADKDYSVTANSK_.3|_IV...

SEN / CTL

Q96SI9

Spermatid perinuclear RNA-binding protein

STRBP

0.53

0.18

0.00684

0.00515

multicellular organism development,spermatid devel...

DNA binding,RNA binding,double-stranded RNA bindin...

nucleus,cytoplasm,microtubule cytoskeleton

3

24

25

_SC[+57]VIVLR_.2|_KDGENVSM[+16]K_.2|_GWPLELIC[+57]...

SEN / CTL

Q86SZ2

Trafficking protein particle complex subunit 6B

TRAPPC6B

0.53

0.55

0.0434

0.0252

ER to Golgi vesicle-mediated transport,positive re...

protein binding,Rab guanyl-nucleotide exchange fac...

Golgi membrane,endoplasmic reticulum,cis-Golgi net...

6

6

7

_TNHQGIYVLQDNK_.3|_TNHQGIYVLQDNK_.2|_GGLSNLGIK_.2|...

SEN / CTL

P14174

Macrophage migration inhibitory factor

MIF

0.52

1.35

0.00655

0.005

prostaglandin biosynthetic process,negative regula...

dopachrome isomerase activity,receptor binding,cyt...

extracellular region,extracellular space,nucleopla...

36

10

22

_LLC[+57]GLLAER_.2|_PMFIVNTNVPR_.2|_PMFIVNTNVPR_.3...

SEN / CTL

P07437

Tubulin beta chain

TUBB

0.52

0.57

0.0711

0.0388

G2/M transition of mitotic cell cycle,movement of ...

GTPase activity,structural molecule activity,struc...

extracellular region,nucleus,nuclear envelope lume...

40

8

21

_ISVYYNEATGGKYVPR_.3|_ALTVPELTQQVFDAK_.2|_ALTVPELT...

SEN / CTL

P08572

Collagen alpha-2(IV) chain

COL4A2

0.52

1.2

0.091

0.048

angiogenesis,transcription, DNA-templated,negative...

extracellular matrix structural constituent,protei...

extracellular region,collagen type IV trimer,extra...

79

15

19

_IAVQPGTVGPQGR_.2|_SVSIGYLLVK_.2|_ATPFIEC[+57]NGGR...

SEN / CTL

P42766

60S ribosomal protein L35

RPL35

0.51

0.35

0.00677

0.00511

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,mRNA binding,structural constituent of...

nucleolus,cytosol,membrane,cytosolic large ribosom...

10

8

10

_VLTVINQTQKENLR_.3|_QLDDLKVELSQLR_.3|_QLDDLKVELSQL...

SEN / CTL

O00151

PDZ and LIM domain protein 1

PDLIM1

0.5

1.62

0.0912

0.048

response to hypoxia,regulation of transcription, D...

transcription coactivator activity,zinc ion bindin...

transcription factor complex,cytoplasm,cytoskeleto...

77

27

50

_C[+57]GTGIVGVFVK_.2|_LVGGKDFEQPLAISR_.3|_LVGGKDFE...

SEN / CTL

P29692

Elongation factor 1-delta

EEF1D

0.49

0.81

0.00414

0.00335

transcription, DNA-templated,regulation of transcr...

DNA binding,translation elongation factor activity...

fibrillar center,nucleus,cytoplasm,cytosol,eukaryo...

51

24

46

_LVPVGYGIR_.2|_IASLEVENQSLR_.2|_IASLEVENQSLR_.3|_S...

SEN / CTL

Q99439

Calponin-2

CNN2

0.48

0.56

0.0112

0.00785

cytoskeleton organization,actomyosin structure org...

actin binding,calmodulin binding,cadherin binding,...

stress fiber,extracellular region,cytoskeleton,cel...

32

17

33

_NFDDATMK_.2|_GLKDGTILC[+57]TLMNK_.3|_GLKDGTILC[+5...

SEN / CTL

Q13561

Dynactin subunit 2

DCTN2

0.47

0.38

0.000127

0.000141

G2/M transition of mitotic cell cycle,ER to Golgi ...

motor activity,protein binding,spectrin binding,id...

kinetochore,cytoplasm,centrosome,cytosol,dynactin ...

28

28

43

_YADLPGIAR_.2|_LTELETAVR_.2|_WSPIASTLPELVQR_.2|_LL...

SEN / CTL

P60903

Protein S100-A10

S100A10

0.46

0.27

0.00121

0.00113

membrane raft assembly,membrane budding,response t...

calcium ion binding,protein binding,protein homodi...

endoplasmic reticulum,extrinsic component of plasm...

13

12

32

_FAGDKGYLTK_.2|_FAGDKGYLTKEDLR_.4|_FAGDKGYLTKEDLR_...

SEN / CTL

P07814

Bifunctional glutamate/proline--tRNA ligase

EPRS

0.46

0.26

0.0034

0.00285

tRNA aminoacylation for protein translation,glutam...

glutamate-tRNA ligase activity,proline-tRNA ligase...

cytoplasm,cytosol,membrane,aminoacyl-tRNA syntheta...

6

124

222

_VAVQGDVVR_.2|_INEAVEC[+57]LLSLK_.2|_INEAVEC[+57]L...

SEN / CTL

Q06830

Peroxiredoxin-1

PRDX1

0.45

0.99

1.57e-12

4.62e-12

response to reactive oxygen species,skeletal syste...

RNA binding,peroxidase activity,protein binding,th...

extracellular space,nucleus,cytoplasm,mitochondrio...

167

29

60

_SVDETLR_.2|_GLFIIDDKGILR_.2|_GLFIIDDKGILR_.3|_ADE...

SEN / CTL

P07900

Heat shock protein HSP 90-alpha

HSP90AA1

0.44

1.28

0.0148

0.0101

G2/M transition of mitotic cell cycle,mitochondria...

nucleotide binding,RNA binding,protein tyrosine ki...

extracellular region,nucleus,nucleoplasm,cytoplasm...

182

69

151

_ALLFVPR_.2|_ELISNSSDALDKIR_.3|_ELISNSSDALDKIR_.2|...

SEN / CTL

P55854 P61956 Q6EEV6

Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2;Small ubiquitin-related modifier 4

SUMO3 SUMO2 SUMO4

0.43

0.15

0.00000613

0.00000868

protein sumoylation,global genome nucleotide-excis...

protein binding,protein tag;RNA binding,protein bi...

kinetochore,nucleus,nucleoplasm,cytoplasm,PML body...

10

1

2

_VAGQDGSVVQFK_.2|_VAGQDGSVVQFK_.3

SEN / CTL

P62906

60S ribosomal protein L10a

RPL10A

0.42

0.43

0.00106

0.000993

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytosol,focal adhesion,membrane,cytosolic ...

14

19

35

_ILGPGLNK_.2|_DTLYEAVR_.2|_KYDAFLASESLIK_.3|_KYDAF...

SEN / CTL

P17931

Galectin-3

LGALS3

0.41

0.65

0.000391

0.000396

monocyte chemotaxis,mRNA processing,RNA splicing,n...

RNA binding,protein binding,IgE binding,carbohydra...

immunological synapse,extracellular space,nucleus,...

70

12

19

_IALDFQR_.2|_GNDVAFHFNPR_.3|_GNDVAFHFNPR_.2|_VIVC[...

SEN / CTL

Q9H444

Charged multivesicular body protein 4b

CHMP4B

0.4

0.37

0.0185

0.0122

mitotic cytokinesis,cell separation after cytokine...

protein binding,identical protein binding,protein ...

ESCRT III complex,nucleus,nuclear envelope,cytopla...

7

12

16

_EALENANTNTEVLK_.2|_GGPTPQEAIQR_.2|_LRDTEEMLSK_.3|...

SEN / CTL

O95399

Urotensin-2

UTS2

0.39

0.16

0.0000255

0.0000328

response to hypoxia,negative regulation of glomeru...

receptor binding,hormone activity

extracellular region,extracellular space,cell

10

1

1

_LTPEELER_.2

SEN / CTL

Q9HB07

UPF0160 protein MYG1, mitochondrial

C12orf10

0.39

0.17

0.0418

0.0244

locomotory exploration behavior,pigmentation

molecular_function

nucleus,nucleoplasm,mitochondrion,extracellular ex...

5

17

26

_ALVEEALAQR_.2|_YALTTTLSAR_.2|_LDFYQHSWLPAR_.3|_LD...

SEN / CTL

P62753

40S ribosomal protein S6

RPS6

0.37

0.49

0.00337

0.00284

G1/S transition of mitotic cell cycle,nuclear-tran...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleoplasm,nucleolus,cytosol,polysome,sma...

27

18

39

_LIEVDDER_.2|_KGEKDIPGLTDTTVPR_.3|_KGEKDIPGLTDTTVP...

SEN / CTL

Q13442

28 kDa heat- and acid-stable phosphoprotein

PDAP1

0.36

0.32

0.0169

0.0112

signal transduction,cell proliferation,neutrophil ...

RNA binding,poly(A) RNA binding

extracellular region,ficolin-1-rich granule lumen

9

15

23

_KGVEGLIDIENPNR_.3|_KGVEGLIDIENPNR_.2|_GVEGLIDIENP...

SEN / CTL

Q9UHV9

Prefoldin subunit 2

PFDN2

0.36

0.82

0.0542

0.0304

protein folding,positive regulation of cytoskeleto...

protein binding,protein binding involved in protei...

nucleus,cytoplasm,mitochondrion,cytosol,prefoldin ...

18

9

15

_GAVSAEQVIAGFNR_.2|_GAVSAEQVIAGFNR_.3|_MVGGVLVER_....

SEN / CTL

P07237

Protein disulfide-isomerase

P4HB

0.35

0.72

3.39e-15

1.4e-14

response to reactive oxygen species,protein foldin...

RNA binding,protein disulfide isomerase activity,i...

extracellular region,endoplasmic reticulum,endopla...

207

62

113

_ALAPEYAK_.2|_EADDIVNWLK_.2|_LKAEGSEIR_.2|_TVIDYNG...

SEN / CTL

Q14247

Src substrate cortactin

CTTN

0.35

0.41

0.000342

0.000351

intracellular protein transport,receptor-mediated ...

protein binding,profilin binding,cadherin binding,...

ruffle,podosome,cytoplasm,Golgi apparatus,cytosol,...

16

43

57

_YGLFPANYVELRQ_.2|_TVPVEAVTSK_.2|_ANFENLAK_.2|_FGV...

SEN / CTL

P62495

Eukaryotic peptide chain release factor subunit 1

ETF1

0.35

0.35

0.00893

0.00647

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,translation release factor activity,pr...

cytoplasm,cytosol,nucleus

7

35

53

_GFGGIGGILR_.2|_LSVLGAITSVQQR_.2|_LSVLGAITSVQQR_.3...

SEN / CTL

Q96D15

Reticulocalbin-3

RCN3

0.35

1.07

0.0956

0.0498

calcium ion binding,protein binding

endoplasmic reticulum lumen

20

13

20

_AGDGDGWVSLAELR_.2|_EVAKEFDQLTPEESQAR_.3|_EVAKEFDQ...

SEN / CTL

P06239 P06241 P07947 P07948 P08631 P09769 P11362 P20794 P21802 P22455 P22607 P51451 Q8IZL9 Q9UPZ9

Tyrosine-protein kinase Lck;Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Yes;Tyrosine-protein kinase Lyn;Tyrosine-protein kinase HCK;Tyrosine-protein kinase Fgr;Fibroblast growth factor receptor 1;Serine/threonine-protein kinase MAK;Fibroblast growth factor receptor 2;Fibroblast growth factor receptor 4;Fibroblast growth factor receptor 3;Tyrosine-protein kinase Blk;Cyclin-dependent kinase 20;Serine/threonine-protein kinase ICK

LCK FYN YES1 LYN HCK FGR FGFR1 MAK FGFR2 FGFR4 FGFR3 BLK CDK20 ICK

0.34

0.02

0.0302

0.0186

protein phosphorylation,protein dephosphorylation,...

glycoprotein binding,protein tyrosine kinase activ...

pericentriolar material,immunological synapse,cyto...

2

1

1

_IADFGLAR_.2

SEN / CTL

P21333

Filamin-A

FLNA

0.33

0.93

3.14e-24

2.19e-23

platelet degranulation,adenylate cyclase-inhibitin...

G-protein coupled receptor binding,glycoprotein bi...

extracellular region,nucleus,nucleolus,cytoplasm,c...

730

207

388

_AGVAPLQVK_.2|_YGGDEIPFSPYR_.2|_SSFTVDC[+57]SK_.2|...

SEN / CTL

P0DMV8 P0DMV9

Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B

HSPA1A HSPA1B

0.31

0.71

5.17e-10

1.24e-9

positive regulation of gene expression,negative re...

RNA polymerase II transcription corepressor activi...

extracellular region,nucleoplasm,cytoplasm,mitocho...

95

60

132

_ITITNDKGR_.2|_TTPSYVAFTDTER_.2|_TTPSYVAFTDTER_.3|...

SEN / CTL

P02461

Collagen alpha-1(III) chain

COL3A1

0.3

0.73

0.000029

0.0000364

skeletal system development,cell-matrix adhesion,t...

integrin binding,extracellular matrix structural c...

extracellular region,collagen type III trimer,extr...

87

25

27

_FTYTVLEDGC[+57]TK_.2|_SGEYWVDPNQGC[+57]K_.2|_LMGS...

SEN / CTL

P06753

Tropomyosin alpha-3 chain

TPM3

0.3

1.31

0.0103

0.00736

movement of cell or subcellular component,muscle c...

molecular_function,protein binding,structural cons...

stress fiber,cytosol,cytoskeleton,muscle thin fila...

163

33

55

_IQLVEEELDRAQER_.3|_IQLVEEELDRAQER_.2|_RIQLVEEELDR...

SEN / CTL

P62750

60S ribosomal protein L23a

RPL23A

0.3

0.46

0.0217

0.014

ribosomal large subunit assembly,nuclear-transcrib...

nucleotide binding,RNA binding,structural constitu...

nucleus,nucleolus,cytoplasm,cytosol,cytosolic larg...

16

15

28

_LYDIDVAK_.2|_LAPDYDALDVANK_.2|_LAPDYDALDVANK_.3|_...

SEN / CTL

P62269

40S ribosomal protein S18

RPS18

0.29

0.42

0.000636

0.00062

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleoplasm,cytosol,ribosome,focal adhesio...

9

17

23

_AGELTEDEVER_.2|_VITIMQNPR_.2|_VITIM[+16]QNPR_.2|_...

SEN / CTL

P61163

Alpha-centractin

ACTR1A

0.29

0.09

0.0229

0.0147

G2/M transition of mitotic cell cycle,spermatogene...

ATP binding

manchette,cytoplasm,centrosome,centriole,cytosol,d...

3

20

33

_YC[+57]FPNYVGRPK_.3|_AGFAGDQIPK_.2|_DQLQTFSEEHPVL...

SEN / CTL

Q9UQ80

Proliferation-associated protein 2G4

PA2G4

0.28

0.51

0.000951

0.000902

transcription, DNA-templated,rRNA processing,regul...

DNA binding,transcription factor activity, sequenc...

extracellular region,nucleus,nucleolus,cytoplasm,m...

30

38

76

_AFFSEVER_.2|_ALLQSSASR_.2|_MGGDIANR_.2|_M[+16]GGD...

SEN / CTL

P22234

Multifunctional protein ADE2

PAICS

0.28

0.14

0.0795

0.0429

'de novo' IMP biosynthetic process,purine nucleoba...

phosphoribosylaminoimidazole carboxylase activity,...

cytoplasm,cytosol,membrane,extracellular exosome,c...

3

31

54

_AC[+57]GNFGIPC[+57]ELR_.2|_DQITAGNAAR_.2|_ITSC[+5...

SEN / CTL

Q9Y3B8

Oligoribonuclease, mitochondrial

REXO2

0.28

0.06

0.0822

0.0441

nucleobase-containing compound metabolic process,n...

nucleic acid binding,3'-5' exonuclease activity,3'...

nucleus,nucleolus,mitochondrion,mitochondrial inte...

3

14

18

_IIDVSTVK_.2|_RWYPEEYEFAPK_.3|_RWYPEEYEFAPK_.2|_WY...

SEN / CTL

P61604

10 kDa heat shock protein, mitochondrial

HSPE1

0.26

0.54

0.0912

0.048

osteoblast differentiation,protein folding,activat...

RNA binding,protein binding,ATP binding,metal ion ...

mitochondrion,mitochondrial matrix,membrane,extrac...

76

19

27

_VLLPEYGGTK_.2|_GGEIQPVSVK_.2|_VGDKVLLPEYGGTK_.3|_...

SEN / CTL

P06744

Glucose-6-phosphate isomerase

GPI

0.25

0.75

0.0168

0.0112

angiogenesis,in utero embryonic development,mesode...

glucose-6-phosphate isomerase activity,cytokine ac...

extracellular region,extracellular space,nucleopla...

75

49

107

_SPEDLER_.2|_INYTEGR_.2|_AVLHVALR_.2|_TLAQLNPESSLF...

SEN / CTL

Q13501

Sequestosome-1

SQSTM1

0.25

0.44

0.0708

0.0387

negative regulation of transcription from RNA poly...

protein serine/threonine kinase activity,protein k...

pre-autophagosomal structure,cytoplasmic mRNA proc...

7

23

34

_AYLLGKEDAAR_.3|_AYLLGKEDAAR_.2|_AGEARPGPTAESASGPS...

SEN / CTL

P06733

Alpha-enolase

ENO1

0.24

1

7.14e-8

1.35e-7

gluconeogenesis,transcription, DNA-templated,respo...

magnesium ion binding,DNA binding,RNA binding,phos...

phosphopyruvate hydratase complex,extracellular sp...

291

52

112

_TIAPALVSK_.2|_VNQIGSVTESLQAC[+57]K_.2|_VNQIGSVTES...

SEN / CTL

P18669

Phosphoglycerate mutase 1

PGAM1

0.24

1.45

0.00874

0.00638

gluconeogenesis,glycolytic process,regulation of g...

bisphosphoglycerate mutase activity,phosphoglycera...

extracellular region,nucleus,cytoplasm,cytosol,mem...

114

38

83

_VLIAAHGNSLR_.2|_HGESAWNLENR_.3|_HGESAWNLENR_.2|_Y...

SEN / CTL

P18621

60S ribosomal protein L17

RPL17

0.23

0.2

0.0000504

0.0000609

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytosol,cytosolic large ribosomal subunit

7

17

35

_YSLDPENPTK_.2|_QWGWTQGR_.2|_VRYSLDPENPTK_.3|_VRYS...

SEN / CTL

Q9UMS4

Pre-mRNA-processing factor 19

PRPF19

0.23

0.77

0.00814

0.006

protein polyubiquitination,spliceosomal tri-snRNP ...

protein binding,ubiquitin-ubiquitin ligase activit...

Prp19 complex,nucleus,nucleoplasm,cytoplasm,lipid ...

6

24

48

_ATVLTTER_.2|_TVPEELVKPEELSK_.3|_TVPEELVKPEELSK_.2...

SEN / CTL

P54652

Heat shock-related 70 kDa protein 2

HSPA2

0.22

1.36

0.0209

0.0135

response to unfolded protein,male meiosis,spermato...

protein binding,ATP binding,enzyme binding,unfolde...

nucleus,cytosol,membrane,CatSper complex,extracell...

95

31

43

_ARFEELNADLFR_.3|_ARFEELNADLFR_.2|_STAGDTHLGGEDFDN...

SEN / CTL

P06576

ATP synthase subunit beta, mitochondrial

ATP5B

0.22

1.29

0.0368

0.0222

angiogenesis,osteoblast differentiation,generation...

transporter activity,protein binding,ATP binding,t...

nucleus,mitochondrion,mitochondrial proton-transpo...

104

47

115

_VVDLLAPYAK_.2|_IGLFGGAGVGK_.2|_AIAELGIYPAVDPLDSTS...

SEN / CTL

Q99497

Protein deglycase DJ-1

PARK7

0.2

0.64

0.0555

0.0311

negative regulation of protein phosphorylation,pos...

transcription coactivator activity,mRNA binding,re...

chromatin,nucleus,cytoplasm,mitochondrion,mitochon...

41

27

55

_VTVAGLAGKDPVQC[+57]SR_.3|_VTVAGLAGKDPVQC[+57]SR_....

SEN / CTL

P02649

Apolipoprotein E

APOE

0.19

0.41

0.00198

0.00173

response to reactive oxygen species,retinoid metab...

beta-amyloid binding,lipid transporter activity,pr...

extracellular region,extracellular space,nucleus,c...

9

24

40

_LQAEAFQAR_.2|_LGPLVEQGR_.2|_LAVYQAGAR_.2|_AKLEEQA...

SEN / CTL

P08123

Collagen alpha-2(I) chain

COL1A2

0.18

1.49

1.88e-10

4.62e-10

skeletal system development,blood vessel developme...

extracellular matrix structural constituent,protei...

extracellular region,collagen type I trimer,extrac...

230

44

57

_GVVGPQGAR_.2|_SLNNQIETLLTPEGSR_.2|_SLNNQIETLLTPEG...

SEN / CTL

Q16658

Fascin

FSCN1

0.18

1.26

0.00000522

0.00000745

cell-cell junction assembly,cell proliferation,ana...

RNA binding,actin binding,protein binding,drug bin...

stress fiber,ruffle,podosome,cytoplasm,cytosol,cyt...

107

44

69

_YLAPSGPSGTLK_.2|_YLTAEAFGFK_.2|_VNASASSLK_.2|_LIN...

SEN / CTL

P05997

Collagen alpha-2(V) chain

COL5A2

0.18

0.75

0.0111

0.00785

skeletal system development,ossification,extracell...

molecular_function,extracellular matrix structural...

extracellular region,collagen type V trimer,extrac...

45

15

16

_SPDNKPVWYGLDMNR_.3|_YIVLQDTC[+57]SK_.2|_NSVGYMDDQ...

SEN / CTL

P28300

Protein-lysine 6-oxidase

LOX

0.18

0.07

0.0648

0.0359

cellular protein modification process,heart develo...

protein-lysine 6-oxidase activity,copper ion bindi...

extracellular region,proteinaceous extracellular m...

2

2

3

_NQGTSDFLPSRPR_.3|_YTGHHAYASGC[+57]TISPY_.3|_YTGHH...

SEN / CTL

P08238

Heat shock protein HSP 90-beta

HSP90AB1

0.17

1.14

0.0000783

0.0000913

placenta development,protein folding,xenobiotic me...

glycoprotein binding,UTP binding,CTP binding,RNA b...

extracellular region,nucleus,nucleoplasm,cytoplasm...

300

84

175

_GVVDSEDLPLNISR_.2|_GVVDSEDLPLNISR_.3|_ALLFIPR_.2|...

SEN / CTL

O00154

Cytosolic acyl coenzyme A thioester hydrolase

ACOT7

0.17

0.31

0.00698

0.00525

coenzyme A biosynthetic process,long-chain fatty-a...

fatty-acyl-CoA binding,protein binding,palmitoyl-C...

nucleoplasm,mitochondrion,cytosol,extracellular ex...

13

22

42

_ATLWYVPLSLK_.2|_KGC[+57]VITISGR_.2|_LMDEVAGIVAAR_...

SEN / CTL

P68363

Tubulin alpha-1B chain

TUBA1B

0.17

1.79

0.0487

0.0279

microtubule cytoskeleton organization,microtubule-...

double-stranded RNA binding,GTPase activity,struct...

microtubule,cytoplasmic microtubule,microtubule cy...

39

3

7

_LISQIVSSITASLR_.2|_LISQIVSSITASLR_.3|_SIQFVDWC[+5...

SEN / CTL

P17655

Calpain-2 catalytic subunit

CAPN2

0.17

0.96

0.0597

0.0332

response to hypoxia,blastocyst development,proteol...

calcium-dependent cysteine-type endopeptidase acti...

chromatin,nucleus,cytoplasm,lysosome,endoplasmic r...

67

45

77

_SDGFSIETC[+57]K_.2|_SDTFINLR_.2|_NFFLTNR_.2|_IRNP...

SEN / CTL

Q9UJU6

Drebrin-like protein

DBNL

0.16

0.33

0.00142

0.00129

adaptive immune response,receptor-mediated endocyt...

actin binding,protein binding,protein C-terminus b...

Golgi membrane,ruffle,podosome,extracellular regio...

6

25

37

_VMYAFC[+57]R_.2|_NGPALQEAYVR_.2|_YQEQGGEASPQR_.2|...

SEN / CTL

O75083

WD repeat-containing protein 1

WDR1

0.16

0.78

0.0135

0.0093

neutrophil mediated immunity,platelet degranulatio...

actin filament binding

podosome,extracellular region,cytosol,cell-cell ju...

98

47

76

_YTSLMLR_.2|_VINSVDIK_.2|_IAVVGEGR_.2|_VFASLPQVER_...

SEN / CTL

Q9Y6R7

IgGFc-binding protein

FCGBP

0.16

0.22

0.0478

0.0274

protein binding

extracellular exosome

3

142

229

_LASVSVSR_.2|_NAAGDLQR_.2|_AQGDPHYTTFDGRR_.4|_AQGD...

SEN / CTL

P68104

Elongation factor 1-alpha 1

EEF1A1

0.14

1.14

0.0129

0.00897

transcription, DNA-templated,regulation of transcr...

tRNA binding,RNA binding,translation elongation fa...

extracellular region,extracellular space,nucleus,n...

225

52

144

_IGGIGTVPVGR_.2|_QTVAVGVIK_.2|_QLIVGVNK_.2|_YYVTII...

SEN / CTL

Q12931

Heat shock protein 75 kDa, mitochondrial

TRAP1

0.14

0.41

0.0146

0.01

response to stress,translational attenuation,chape...

RNA binding,tumor necrosis factor receptor binding...

nucleoplasm,mitochondrion,mitochondrial inner memb...

20

53

85

_GVVDSEDIPLNLSR_.2|_GVVDSEDIPLNLSR_.3|_LNELLVK_.2|...

SEN / CTL

P61254

60S ribosomal protein L26

RPL26

0.14

0.29

0.0152

0.0103

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,membrane,cytosolic large ribosomal subunit...

3

9

17

_YVIYIER_.2|_IMSSPLSK_.2|_IM[+16]SSPLSK_.2|_FNPFVT...

SEN / CTL

Q01082

Spectrin beta chain, non-erythrocytic 1

SPTBN1

0.13

0.58

0.0339

0.0206

MAPK cascade,mitotic cytokinesis,ER to Golgi vesic...

RNA binding,actin binding,Ras guanyl-nucleotide ex...

nucleolus,cytoplasm,cytosol,spectrin,postsynaptic ...

17

217

362

_VQAVVAVAR_.2|_LISDINK_.2|_VAVVNQIAR_.2|_SLLDAC[+5...

SEN / CTL

P02656

Apolipoprotein C-III

APOC3

0.11

0.43

0.0098

0.00702

retinoid metabolic process,triglyceride metabolic ...

phospholipid binding,cholesterol binding,enzyme re...

extracellular region,extracellular space,early end...

11

3

4

_DALSSVQESQVAQQAR_.2|_DALSSVQESQVAQQAR_.3|_TAKDALS...

SEN / CTL

Q04837

Single-stranded DNA-binding protein, mitochondrial

SSBP1

0.1

0.24

0.0108

0.00763

DNA replication,mitochondrion organization,positiv...

chromatin binding,single-stranded DNA binding,RNA ...

nucleus,mitochondrion,mitochondrial matrix,mitocho...

6

10

18

_VGQDPVLR_.2|_DVAYQYVK_.2|_SGDSEVYQLGDVSQK_.2|_SGD...

SEN / CTL

P11142

Heat shock cognate 71 kDa protein

HSPA8

0.09

1.07

0.00295

0.00251

mRNA splicing, via spliceosome,transcription, DNA-...

G-protein coupled receptor binding,phosphatidylser...

Prp19 complex,extracellular region,extracellular s...

258

47

112

_SQIHDIVLVGGSTR_.3|_SQIHDIVLVGGSTR_.2|_VC[+57]NPII...

SEN / CTL

Q96HC4

PDZ and LIM domain protein 5

PDLIM5

0.04

0.24

0.00000858

0.0000118

regulation of synapse assembly,regulation of dendr...

actin binding,protein kinase C binding,protein bin...

cytosol,cell-cell adherens junction,postsynaptic d...

21

30

44

_FFAPEC[+57]GR_.2|_GPFLVALGK_.2|_EVVKPVPITSPAVSK_....

SEN / CTL

O14950 P19105

Myosin regulatory light chain 12B;Myosin regulatory light chain 12A

MYL12B MYL12A

0.04

0.58

0.0853

0.0457

muscle contraction,regulation of cell shape;muscle...

calcium ion binding,protein binding,myosin heavy c...

stress fiber,cytosol,brush border,myosin II comple...

22

18

38

_GNFNYIEFTR_.2|_LNGTDPEDVIR_.2|_ELLTTMGDRFTDEEVDEL...

SEN / CTL

P43034

Platelet-activating factor acetylhydrolase IB subunit alpha

PAFAH1B1

0.03

0.29

5.27e-13

1.7e-12

G2/M transition of mitotic cell cycle,establishmen...

phospholipase A2 activity,protein binding,microtub...

astral microtubule,kinetochore,nuclear envelope,ce...

34

27

45

_AIADYLR_.2|_LWDFQGFEC[+57]IR_.2|_VWVVATK_.2|_TAPY...

SEN / CTL

P48643

T-complex protein 1 subunit epsilon

CCT5

0.03

0.77

0.000138

0.000151

protein folding,'de novo' protein folding,binding ...

protein binding,ATP binding,G-protein beta-subunit...

zona pellucida receptor complex,nucleolus,centroso...

58

49

103

_IADGYEQAAR_.2|_AVTIFIR_.2|_FSELTAEK_.2|_SLHDALC[+...

SEN / CTL

O75369

Filamin-B

FLNB

0.02

0.77

0.000818

0.000784

keratinocyte development,epithelial cell morphogen...

RNA binding,actin binding,protein binding,identica...

stress fiber,cytoplasm,cytosol,plasma membrane,bru...

141

210

349

_IQQNTFTR_.2|_LLGWIQNK_.2|_LIALLEVLSQK_.2|_IAGPGLG...

SEN / CTL

Q9NP79

Vacuolar protein sorting-associated protein VTA1 homolog

VTA1

0.02

0.05

0.0411

0.0242

protein transport,endosomal transport,macroautopha...

protein binding,protein C-terminus binding

nucleoplasm,cytosol,endosome membrane,intracellula...

2

12

19

_LTPEDFAR_.2|_TAQEHDKRDPVVAYYC[+57]R_.5|_TAQEHDKRD...

SEN / CTL

Q15121

Astrocytic phosphoprotein PEA-15

PEA15

0.01

0.31

0.0263

0.0164

DNA damage checkpoint,MAPK cascade,activation of M...

protein binding

nucleus,cytosol,microtubule associated complex

5

11

16

_RPDLLTMVVDYR_.3|_RPDLLTMVVDYR_.2|_ISEEDELDTK_.2|_...

SEN / CTL

Q6IBS0

Twinfilin-2

TWF2

0

0.34

0.00000691

0.00000964

positive regulation of lamellipodium assembly,posi...

RNA binding,actin monomer binding,protein kinase C...

cytoplasm,cytoskeleton,myofibril,lamellipodium,fil...

15

26

45

_MLYSSC[+57]K_.2|_MLYAATR_.2|_TEISVESK_.2|_LDLERET...

SEN / CTL

P60983

Glia maturation factor beta

GMFB

0

0.14

0.00465

0.00366

protein phosphorylation,negative regulation of pro...

actin binding,protein kinase inhibitor activity,si...

intracellular

7

11

15

_FIVYSYK_.2|_ETNNAAIIMK_.2|_LVVLDEELEGISPDELKDELPE...

SEN / CTL

P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1

-0.01

0.36

0.0522

0.0295

response to ischemia,axon target recognition,adult...

cysteine-type endopeptidase activity,thiol-depende...

nucleoplasm,cytoplasm,endoplasmic reticulum membra...

85

20

39

_FSAVALC[+57]K_.2|_LGVAGQWR_.2|_EFTEREQGEVR_.3|_QF...

SEN / CTL

Q15599

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

SLC9A3R2

-0.02

0.3

0.00633

0.00484

protein complex assembly,cell-cell adhesion

receptor binding,protein binding,beta-catenin bind...

nucleus,plasma membrane,focal adhesion,endomembran...

6

18

23

_SVDPGSPAAR_.2|_RVEPGSPAEAAALR_.3|_RVEPGSPAEAAALR_...

SEN / CTL

P30086

Phosphatidylethanolamine-binding protein 1

PEBP1

-0.02

0.9

0.0253

0.0159

MAPK cascade,negative regulation of endopeptidase ...

RNA binding,serine-type endopeptidase inhibitor ac...

nucleus,cytosol,extracellular exosome

56

25

48

_VLTPTQVK_.2|_LYEQLSGK_.2|_YVWLVYEQDRPLKC[+57]DEPI...

SEN / CTL

P61981

14-3-3 protein gamma

YWHAG

-0.03

0.4

0.000214

0.000227

G2/M transition of mitotic cell cycle,negative reg...

RNA binding,protein kinase C binding,insulin-like ...

mitochondrion,cytosol,focal adhesion,membrane,cyto...

52

21

36

_YLAEVATGEKR_.3|_YLAEVATGEKR_.2|_NC[+57]SETQYESK_....

SEN / CTL

Q13404

Ubiquitin-conjugating enzyme E2 variant 1

UBE2V1

-0.04

0.29

0.00000785

0.0000109

activation of MAPK activity,protein polyubiquitina...

protein binding,ubiquitin protein ligase binding,u...

ubiquitin ligase complex,nucleus,nucleoplasm,cytop...

14

10

16

_VVLQELR_.2|_WTGMIIGPPR_.2|_WTGM[+16]IIGPPR_.2|_IE...

SEN / CTL

P61970

Nuclear transport factor 2

NUTF2

-0.05

0.25

0.0000849

0.000098

protein import into nucleus, translocation,protein...

protein binding,protein transmembrane transporter ...

nuclear inner membrane,nuclear outer membrane,nucl...

13

8

20

_LSSLPFQK_.2|_NINDAWVC[+57]TNDMFR_.2|_NINDAWVC[+57...

SEN / CTL

P07686

Beta-hexosaminidase subunit beta

HEXB

-0.05

0.77

0.00288

0.00246

skeletal system development,glycosphingolipid meta...

beta-N-acetylhexosaminidase activity,acetylglucosa...

acrosomal vesicle,extracellular region,extracellul...

43

27

38

_VLDIIATINK_.2|_PGPALWPLPLSVK_.2|_DLLTPC[+57]YSR_....

SEN / CTL

P13639

Elongation factor 2

EEF2

-0.05

1.04

0.0174

0.0115

hematopoietic progenitor cell differentiation,resp...

p53 binding,RNA binding,translation elongation fac...

extracellular region,nucleus,cytoplasm,cytosol,pla...

266

84

183

_GGGQIIPTAR_.2|_FSVSPVVR_.2|_VNFTVDQIR_.2|_GEGQLGP...

SEN / CTL

Q15149

Plectin

PLEC

-0.06

0.93

5.32e-11

1.34e-10

hemidesmosome assembly,cell-cell adhesion

RNA binding,actin binding,protein binding,structur...

cytosol,plasma membrane,brush border,focal adhesio...

436

489

728

_LTVDEAVR_.2|_LAAEQELIR_.2|_LTVEEAVR_.2|_LLEAAAQST...

SEN / CTL

Q00610

Clathrin heavy chain 1

CLTC

-0.06

1.24

0.000787

0.000757

osteoblast differentiation,intracellular protein t...

RNA binding,double-stranded RNA binding,structural...

lysosome,endosome,spindle,cytosol,plasma membrane,...

166

154

302

_VANVELYYR_.2|_C[+57]NEPAVWSQLAK_.2|_YIQAAC[+57]K_...

SEN / CTL

Q99832

T-complex protein 1 subunit eta

CCT7

-0.06

0.96

0.0184

0.0121

protein folding,'de novo' protein folding,binding ...

protein binding,ATP binding,identical protein bind...

zona pellucida receptor complex,cytoplasm,mitochon...

42

48

102

_ALEIIPR_.2|_TC[+57]TFILR_.2|_TATQLAVNK_.2|_YNFFTG...

SEN / CTL

P02452

Collagen alpha-1(I) chain

COL1A1

-0.07

1.85

9.75e-7

0.00000154

skeletal system development,blood vessel developme...

extracellular matrix structural constituent,protei...

extracellular region,collagen type I trimer,extrac...

289

47

55

_SLSQQIENIR_.2|_ALLLQGSNEIEIR_.2|_DRDLEVDTTLK_.3|_...

SEN / CTL

P83881

60S ribosomal protein L36a

RPL36A

-0.07

0.29

0.00577

0.00449

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,ribosome,plasma membrane,cytosolic large r...

8

10

11

_LEC[+57]VEPNC[+57]R_.2|_QSGYGGQTKPIFR_.3|_IVLRLEC...

SEN / CTL

P10644

cAMP-dependent protein kinase type I-alpha regulatory subunit

PRKAR1A

-0.07

0.52

0.0412

0.0242

mesoderm formation,renal water homeostasis,regulat...

cAMP-dependent protein kinase inhibitor activity,p...

cytoplasm,cytosol,cAMP-dependent protein kinase co...

15

28

40

_ILMGSTLR_.2|_SENEEFVEVGR_.2|_VLGPC[+57]SDILKR_.3|...

SEN / CTL

P46778

60S ribosomal protein L21

RPL21

-0.08

0.55

0.00135

0.00124

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,membrane,cytosolic large ribosomal subunit...

10

10

17

_GTWVQLK_.2|_VYNVTQHAVGIVVNK_.3|_VYNVTQHAVGIVVNK_....

SEN / CTL

P63167

Dynein light chain 1, cytoplasmic

DYNLL1

-0.11

0.22

0.00198

0.00173

G2/M transition of mitotic cell cycle,transcriptio...

motor activity,protein binding,protein C-terminus ...

kinetochore,nucleus,cytoplasm,mitochondrion,centro...

7

7

13

_YNPTWHC[+57]IVGR_.3|_YNPTWHC[+57]IVGR_.2|_NADMSEE...

SEN / CTL

Q12792

Twinfilin-1

TWF1

-0.11

0.73

0.0113

0.00792

negative regulation of actin filament polymerizati...

actin monomer binding,ATP binding,phosphatidylinos...

cytosol,cell-cell junction,focal adhesion,actin cy...

12

22

29

_LLEIVER_.2|_QLQMDVIR_.2|_HQTLQGVAFPISR_.3|_HQTLQG...

SEN / CTL

P46776

60S ribosomal protein L27a

RPL27A

-0.12

1.47

0.0371

0.0223

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

endoplasmic reticulum,cytosol,membrane,cytosolic l...

11

12

15

_TGAAPIIDVVR_.2|_NKTGAAPIIDVVR_.3|_NKTGAAPIIDVVR_....

SEN / CTL

P30041

Peroxiredoxin-6

PRDX6

-0.14

0.5

0.0000123

0.0000164

response to reactive oxygen species,lipid cataboli...

glutathione peroxidase activity,protein binding,hy...

extracellular region,extracellular space,cytoplasm...

62

31

62

_NFDEILR_.2|_LSILYPATTGR_.2|_PGGLLLGDVAPNFEANTTVGR...

SEN / CTL

Q7L576

Cytoplasmic FMR1-interacting protein 1

CYFIP1

-0.14

0.2

0.00752

0.00561

regulation of cell shape,Rac protein signal transd...

RNA 7-methylguanosine cap binding,protein binding,...

ruffle,extracellular region,cytosol,mRNA cap bindi...

3

66

100

_LGTPQQIAIAR_.2|_DIVEYAELK_.2|_HVQLLGR_.2|_TLMEVMP...

SEN / CTL

Q9Y2J2

Band 4.1-like protein 3

EPB41L3

-0.14

0.53

0.0902

0.0477

regulation of cell growth,protein localization to ...

actin binding,structural constituent of cytoskelet...

cytosol,cytoskeleton,plasma membrane,cell-cell jun...

3

50

69

_AVLEQEETAAASR_.2|_GQVLFDK_.2|_HQTNISELKR_.3|_VC[+...

SEN / CTL

P80723

Brain acid soluble protein 1

BASP1

-0.15

0.37

3.8e-14

1.34e-13

thorax and anterior abdomen determination,gonad de...

transcription corepressor activity,protein binding...

nucleus,cytoplasm,cytoskeleton,plasma membrane,nuc...

36

28

41

_AQGPAASAEEPKPVEAPAANSDQTVTVKE_.3|_AQGPAASAEEPKPVE...

SEN / CTL

P49006

MARCKS-related protein

MARCKSL1

-0.15

0.34

0.000823

0.000786

positive regulation of cell proliferation

actin binding,protein binding,calmodulin binding

cytoplasm,plasma membrane,extracellular exosome

5

8

13

_GDVTAEEAAGASPAK_.2|_GDVTAEEAAGASPAK_.3|_AAATPESQE...

SEN / CTL

Q9HD42

Charged multivesicular body protein 1a

CHMP1A

-0.15

0.12

0.00766

0.0057

cell separation after cytokinesis,transcription, D...

protein binding,metallopeptidase activity,zinc ion...

condensed nuclear chromosome,ESCRT III complex,ear...

3

5

5

_VYAENAIR_.2|_VQTAVTMK_.2|_ALSTMDLQK_.2|_NEGVNWLR_...

SEN / CTL

Q9Y281

Cofilin-2

CFL2

-0.16

0.57

0.00000301

0.00000444

skeletal muscle tissue development,actin filament ...

protein binding,actin filament binding

extracellular space,actin cytoskeleton,nuclear mat...

98

17

27

_ESKKEDLVFIFWAPESAPLK_.4|_ESKKEDLVFIFWAPESAPLK_.3|...

SEN / CTL

P08670

Vimentin

VIM

-0.16

1.62

0.0000256

0.0000328

movement of cell or subcellular component,positive...

glycoprotein binding,double-stranded RNA binding,s...

cytoplasm,peroxisome,cytosol,cytoskeleton,intermed...

919

93

188

_ILLAELEQLKGQGK_.3|_ILLAELEQLKGQGK_.2|_KVESLQEEIAF...

SEN / CTL

Q99536

Synaptic vesicle membrane protein VAT-1 homolog

VAT1

-0.17

0.78

0.00544

0.00425

negative regulation of mitochondrial fusion,neutro...

zinc ion binding,oxidoreductase activity

extracellular region,mitochondrial outer membrane,...

34

28

53

_VLLVPGPEKEN_.2|_LQSRPAAPPAPGPGQLTLR_.3|_LQSRPAAPP...

SEN / CTL

Q9Y696

Chloride intracellular channel protein 4

CLIC4

-0.17

0.79

0.0387

0.0231

angiogenesis,endothelial cell morphogenesis,chlori...

voltage-gated ion channel activity,chloride channe...

intracellular,cytoplasm,mitochondrion,centrosome,c...

62

24

43

_NSRPEANEALER_.3|_NSRPEANEALER_.2|_YLTNAYSRDEFTNTC...

SEN / CTL

P60709 P63261

Actin, cytoplasmic 1;Actin, cytoplasmic 2

ACTB ACTG1

-0.18

1.34

0.00135

0.00124

retina homeostasis,movement of cell or subcellular...

structural constituent of cytoskeleton,protein bin...

nuclear chromatin,extracellular space,nucleoplasm,...

698

35

122

_AVFPSIVGRPR_.3|_AVFPSIVGRPR_.2|_AGFAGDDAPR_.2|_VA...

SEN / CTL

O00462

Beta-mannosidase

MANBA

-0.18

0.55

0.00319

0.00269

cellular protein modification process,oligosacchar...

beta-mannosidase activity,mannose binding

plasma membrane,azurophil granule membrane,lysosom...

7

10

12

_YSFDITNVVR_.2|_VNLILEGVDTVSK_.2|_FQSAVLYAAQQSK_.2...

SEN / CTL

P22061

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

PCMT1

-0.18

0.57

0.00398

0.00326

protein methylation,protein repair,cell-cell adhes...

protein-L-isoaspartate (D-aspartate) O-methyltrans...

cytoplasm,cytosol,extracellular exosome,extracellu...

20

19

49

_VQLVVGDGR_.2|_ALDVGSGSGILTAC[+57]FAR_.2|_ALDVGSGS...

SEN / CTL

Q9Y266

Nuclear migration protein nudC

NUDC

-0.19

0.27

9.12e-8

1.69e-7

protein folding,sister chromatid cohesion,mitotic ...

protein binding,cadherin binding,unfolded protein ...

nucleoplasm,cytoplasm,cytosol,microtubule,cell-cel...

19

34

61

_LVSSDPEINTK_.2|_LSDLDSETR_.2|_SETSGPQIK_.2|_LITQT...

SEN / CTL

P35080

Profilin-2

PFN2

-0.19

0.2

0.000447

0.000445

negative regulation of epithelial cell migration,a...

adenyl-nucleotide exchange factor activity,actin m...

cytoplasm,cytoskeleton,terminal bouton,extracellul...

9

8

11

_SQGGEPTYNVAVGR_.2|_SQGGEPTYNVAVGR_.3|_TKSQGGEPTYN...

SEN / CTL

P31946

14-3-3 protein beta/alpha

YWHAB

-0.19

1.15

0.0569

0.0318

MAPK cascade,protein targeting,viral process,negat...

transcription corepressor activity,protein binding...

nucleus,cytoplasm,mitochondrion,cytosol,focal adhe...

100

37

87

_NLLSVAYK_.2|_NLLSVAYK_.1|_VISSIEQK_.2|_AVTEQGHELS...

SEN / CTL

P50552

Vasodilator-stimulated phosphoprotein

VASP

-0.2

1.05

0.000201

0.000215

neural tube closure,axon guidance,actin polymeriza...

actin binding,protein binding,profilin binding,SH3...

cytosol,plasma membrane,bicellular tight junction,...

29

28

48

_VPAQSESVR_.2|_WLPAGTGPQAFSR_.2|_VKEEIIEAFVQELR_.3...

SEN / CTL

Q14019

Coactosin-like protein

COTL1

-0.2

0.83

0.00179

0.00159

biological_process,neutrophil degranulation,defens...

actin binding,protein binding,enzyme binding

extracellular region,nucleus,cytoskeleton,secretor...

67

20

26

_EVVQNFAK_.2|_AAYNLVR_.2|_SKFALITWIGENVSGLQR_.3|_S...

SEN / CTL

Q9BUF5

Tubulin beta-6 chain

TUBB6

-0.22

1.1

0.00602

0.00464

cytoskeleton organization,microtubule-based proces...

molecular_function,GTPase activity,structural cons...

nucleus,cytoplasm,microtubule,microtubule cytoskel...

35

25

55

_YLTVATVFR_.2|_ISEQFSAMFR_.2|_MASTFIGNSTAIQELFKR_....

SEN / CTL

P31947

14-3-3 protein sigma

SFN

-0.23

0.35

0.00033

0.000341

regulation of cyclin-dependent protein serine/thre...

protein binding,protein kinase C inhibitor activit...

extracellular space,nucleus,mitochondrion,cytosol,...

16

23

49

_VLSSIEQK_.2|_VLSSIEQK_.1|_RIIDSAR_.2|_YLAEVATGDDK...

SEN / CTL

Q99426

Tubulin-folding cofactor B

TBCB

-0.23

0.31

0.0307

0.0189

nervous system development,cell differentiation

protein binding

cytoplasm,cytosol,microtubule,microtubule cytoskel...

11

20

26

_AQASSIPVGSR_.2|_LGEYEDVSR_.2|_SLTIAEFK_.2|_RGTVMY...

SEN / CTL

P09486

SPARC

SPARC

-0.25

0.62

9.4e-7

0.0000015

ossification,negative regulation of endothelial ce...

calcium ion binding,protein binding,collagen bindi...

extracellular region,basement membrane,extracellul...

155

14

22

_YIPPC[+57]LDSELTEFPLR_.2|_YIPPC[+57]LDSELTEFPLR_....

SEN / CTL

P62854

40S ribosomal protein S26

RPS26

-0.25

0.14

0.00000849

0.0000117

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,mRNA binding,structural constituent of...

nucleoplasm,cytosol,small ribosomal subunit,membra...

10

6

9

_NIVEAAAVR_.2|_DISEASVFDAYVLPK_.2|_DISEASVFDAYVLPK...

SEN / CTL

P78371

T-complex protein 1 subunit beta

CCT2

-0.25

1.31

0.0698

0.0384

protein folding,binding of sperm to zona pellucida...

protein binding,ATP binding,ubiquitin protein liga...

zona pellucida receptor complex,extracellular regi...

68

49

108

_LAVEAVLR_.2|_NIGVDNPAAK_.2|_GATQQILDEAER_.2|_GATQ...

SEN / CTL

P35221

Catenin alpha-1

CTNNA1

-0.27

0.27

0.0135

0.0093

ovarian follicle development,actin filament organi...

RNA binding,structural molecule activity,protein b...

acrosomal vesicle,Golgi apparatus,cytosol,plasma m...

4

64

112

_IVAEC[+57]NAVR_.2|_IAEQVASFQEEK_.2|_ALLSAVTR_.2|_...

SEN / CTL

P29401

Transketolase

TKT

-0.28

2.09

0.00000148

0.00000224

xylulose biosynthetic process,pentose-phosphate sh...

transketolase activity,protein binding,protein hom...

nucleoplasm,peroxisome,cytosol,nuclear body,nuclea...

94

53

103

_AVELAANTK_.2|_IIALDGDTK_.2|_DAIAQAVR_.2|_SVPTSTVF...

SEN / CTL

P05413

Fatty acid-binding protein, heart

FABP3

-0.28

0.11

0.00401

0.00328

fatty acid metabolic process,negative regulation o...

long-chain fatty acid transporter activity,protein...

extracellular space,cytosol,sarcoplasm,extracellul...

4

8

11

_SLGVGFATR_.2|_SIVTLDGGK_.2|_WDGQETTLVR_.2|_NGDILT...

SEN / CTL

Q16643

Drebrin

DBN1

-0.29

0.51

3.95e-9

8.99e-9

actin filament organization,cell communication by ...

actin binding,protein binding,profilin binding,cad...

cytoplasm,plasma membrane,gap junction,cell cortex...

44

35

56

_DSQAALPK_.2|_SPSDSSTASTPVAEQIER_.2|_SPSDSSTASTPVA...

SEN / CTL

P21291

Cysteine and glycine-rich protein 1

CSRP1

-0.29

1.17

0.000428

0.00043

platelet aggregation

RNA binding,zinc ion binding,poly(A) RNA binding

nucleus,focal adhesion,extracellular exosome

48

16

31

_C[+57]SQAVYAAEK_.2|_GLESTTLADKDGEIYC[+57]K_.3|_GL...

SEN / CTL

P13645

Keratin, type I cytoskeletal 10

KRT10

-0.3

1.28

7.98e-20

4.44e-19

keratinocyte differentiation,keratinization,cornif...

structural constituent of epidermis

extracellular space,nucleus,cytoplasm,cytosol,inte...

297

51

100

_IRLENEIQTYR_.3|_IRLENEIQTYR_.2|_LKYENEVALR_.3|_LK...

SEN / CTL

P62158

Calmodulin

CALM1

-0.31

0.82

0.00127

0.00117

MAPK cascade,response to amphetamine,regulation of...

Ras guanyl-nucleotide exchange factor activity,cal...

spindle pole,extracellular region,nucleus,nucleopl...

53

13

30

_VFDKDGNGYISAAELR_.3|_VFDKDGNGYISAAELR_.2|_EAFSLFD...

SEN / CTL

P83731

60S ribosomal protein L24

RPL24

-0.31

0.99

0.0415

0.0243

ribosomal large subunit assembly,nuclear-transcrib...

RNA binding,structural constituent of ribosome,pro...

cytoplasm,cytosol,membrane,cytosolic large ribosom...

20

10

16

_QINWTVLYR_.2|_VFQFLNAK_.2|_AITGASLADIMAK_.2|_AITG...

SEN / CTL

P35579

Myosin-9

MYH9

-0.32

0.86

3.92e-15

1.59e-14

meiotic spindle organization,cytokinesis,angiogene...

microfilament motor activity,RNA binding,motor act...

stress fiber,ruffle,uropod,nucleus,cytoplasm,spind...

756

259

512

_ASITALEAK_.2|_NTNPNFVR_.2|_GALALEEK_.2|_ALELDSNLY...

SEN / CTL

P36955

Pigment epithelium-derived factor

SERPINF1

-0.32

0.52

1.36e-12

4.04e-12

kidney development,multicellular organism developm...

serine-type endopeptidase inhibitor activity,prote...

extracellular region,basement membrane,extracellul...

60

20

26

_LQSLFDSPDFSK_.2|_DTDTGALLFIGK_.2|_YGLDSDLSC[+57]K...

SEN / CTL

P20908

Collagen alpha-1(V) chain

COL5A1

-0.33

1.16

0.00195

0.00171

blood vessel development,heart morphogenesis,cell ...

integrin binding,extracellular matrix structural c...

extracellular region,collagen type V trimer,baseme...

63

15

18

_DAQLSAPTK_.2|_QLYPASAFPEDFSILTTVK_.2|_VLDFHNLPDGI...

SEN / CTL

O75223

Gamma-glutamylcyclotransferase

GGCT

-0.33

0.05

0.00497

0.0039

release of cytochrome c from mitochondria,glutathi...

gamma-glutamylcyclotransferase activity,protein ho...

cytosol,extracellular exosome

3

15

18

_NPSAAFFC[+57]VAR_.2|_NPSAAFFC[+57]VAR_.3|_VSEEIED...

SEN / CTL

P07737

Profilin-1

PFN1

-0.33

1.2

0.0082

0.00603

neural tube closure,positive regulation of epithel...

adenyl-nucleotide exchange factor activity,RNA bin...

nucleus,cytoplasm,cytosol,cytoskeleton,focal adhes...

158

19

37

_TFVNITPAEVGVLVGKDR_.3|_TFVNITPAEVGVLVGKDR_.2|_TDK...

SEN / CTL

Q86VP6

Cullin-associated NEDD8-dissociated protein 1

CAND1

-0.33

0.75

0.0239

0.0152

SCF complex assembly,protein ubiquitination,cell d...

protein binding,TBP-class protein binding

ubiquitin ligase complex,extracellular region,nucl...

10

81

119

_NVVAEC[+57]LGK_.2|_TVSPALISR_.2|_EGPAVVGQFIQDVK_....

SEN / CTL

P35908

Keratin, type II cytoskeletal 2 epidermal

KRT2

-0.34

1.24

4.51e-9

1e-8

keratinocyte development,epidermis development,ker...

structural constituent of cytoskeleton,protein bin...

extracellular space,nucleus,cytosol,intermediate f...

250

57

106

_SLVGLGGTK_.2|_YLDGLTAER_.2|_IEISELNR_.2|_STSSFSC[...

SEN / CTL

P62942

Peptidyl-prolyl cis-trans isomerase FKBP1A

FKBP1A

-0.34

0.46

6.53e-7

0.00000107

protein peptidyl-prolyl isomerization,heart morpho...

peptidyl-prolyl cis-trans isomerase activity,signa...

cytoplasm,cytosol,terminal cisterna,membrane,Z dis...

28

8

23

_GVQVETISPGDGR_.2|_GVQVETISPGDGR_.3|_GWEEGVAQMSVGQ...

SEN / CTL

P35241

Radixin

RDX

-0.34

1

0.00455

0.00362

regulation of cell shape,regulation of cell size,p...

RNA binding,actin binding,protein binding,protein ...

ruffle,extracellular space,plasma membrane,microvi...

92

51

88

_IGFPWSEIR_.2|_APDFVFYAPR_.2|_LFFLQVK_.2|_QLFDQVVK...

SEN / CTL

O75347

Tubulin-specific chaperone A

TBCA

-0.35

0.35

4.25e-17

1.9e-16

protein folding,tubulin complex assembly,post-chap...

RNA binding,protein binding,beta-tubulin binding,c...

nucleolus,cytoplasm,microtubule,microtubule cytosk...

68

14

23

_RLEAAYLDLQR_.3|_RLEAAYLDLQR_.2|_QAEILQESR_.2|_LEA...

SEN / CTL

P42677 Q71UM5

40S ribosomal protein S27;40S ribosomal protein S27-like

RPS27 RPS27L

-0.37

0.19

0.0000854

0.0000981

ribosomal small subunit assembly,nuclear-transcrib...

DNA binding,RNA binding,structural constituent of ...

nucleus,nucleoplasm,cytosol,ribosome,cytosolic sma...

9

2

4

_LTEGC[+57]SFR_.2|_LVQSPNSYFMDVK_.2|_LVQSPNSYFMDVK...

SEN / CTL

Q15027

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

ACAP1

-0.37

0.32

0.0018

0.00159

protein transport,positive regulation of GTPase ac...

GTPase activator activity,protein binding,metal io...

membrane,intracellular membrane-bounded organelle,...

10

14

16

_RAQEAEEAGAALRTAR_.4|_RAQEAEEAGAALRTAR_.3|_EGPGGLV...

SEN / CTL

Q8TD08

Mitogen-activated protein kinase 15

MAPK15

-0.37

0.17

0.00233

0.00201

MAPK cascade,regulation of gene expression,positiv...

MAP kinase activity,protein binding,ATP binding,SH...

extracellular region,intracellular,nucleus,cytopla...

6

1

1

_LC[+57]DFGLAR_.2

SEN / CTL

P46781

40S ribosomal protein S9

RPS9

-0.38

0.29

6.92e-7

0.00000113

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ri...

10

19

26

_LIGEYGLR_.2|_LFEGNALLR_.2|_IGVLDEGK_.2|_QVVNIPSFI...

SEN / CTL

Q07065

Cytoskeleton-associated protein 4

CKAP4

-0.38

1.61

0.00538

0.00422

neutrophil degranulation,cellular protein metaboli...

RNA binding,poly(A) RNA binding

cytoplasmic mRNA processing body,endoplasmic retic...

17

55

81

_LALQALTEK_.2|_LSSLDNLK_.2|_ASVSQVEADLK_.2|_VQEQVH...

SEN / CTL

P49207

60S ribosomal protein L34

RPL34

-0.41

0.33

2.68e-7

4.64e-7

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,cad...

mitochondrion,cytosol,cytosolic large ribosomal su...

16

9

10

_IVYLYTK_.2|_AFLIEEQK_.2|_LSYNTASNK_.2|_AYGGSMC[+5...

SEN / CTL

P28799

Granulins

GRN

-0.41

1.01

0.0000709

0.0000835

signal transduction,neutrophil degranulation

RNA binding,cytokine activity,protein binding,grow...

extracellular region,extracellular space,lysosome,...

51

18

23

_GSEIVAGLEK_.2|_SRC[+57]PDGSTC[+57]C[+57]ELPSGK_.3...

SEN / CTL

O95967

EGF-containing fibulin-like extracellular matrix protein 2

EFEMP2

-0.43

0.45

4.44e-9

9.95e-9

extracellular matrix structural constituent,calciu...

extracellular region,basement membrane,extracellul...

21

6

6

_AGNSQGDFYIR_.2|_C[+57]LC[+57]PASNPLC[+57]R_.2|_C[...

SEN / CTL

P62241

40S ribosomal protein S8

RPS8

-0.43

0.76

0.0000328

0.0000409

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleus,nucleoplasm,endoplasmic reticulum,cytosol,...

69

23

39

_IIDVVYNASNNELVR_.2|_IIDVVYNASNNELVR_.3|_ELEFYLR_....

SEN / CTL

P16035

Metalloproteinase inhibitor 2

TIMP2

-0.43

0.92

0.0502

0.0287

central nervous system development,aging,negative ...

protease binding,integrin binding,protein binding,...

extracellular region,proteinaceous extracellular m...

67

8

11

_AVSEKEVDSGNDIYGNPIKR_.4|_AVSEKEVDSGNDIYGNPIKR_.3|...

SEN / CTL

P04259

Keratin, type II cytoskeletal 6B

KRT6B

-0.44

1.22

0.0578

0.0322

cytoskeleton organization,ectoderm development,ker...

structural constituent of cytoskeleton,protein bin...

cytosol,keratin filament,extracellular exosome

19

9

14

_YEELQITAGR_.2|_YEELQITAGR_.1|_SGFSSISVSR_.2|_QLDN...

SEN / CTL

P62829

60S ribosomal protein L23

RPL23

-0.45

0.31

0.00000536

0.00000762

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleolus,cytosol,ribosome,focal adhesion,membrane...

11

14

27

_GSAITGPVAK_.2|_NLYIISVK_.2|_EC[+57]ADLWPR_.2|_ISL...

SEN / CTL

Q5TZA2

Rootletin

CROCC

-0.45

0.19

0.000106

0.000119

cell cycle,protein localization,centriole-centriol...

actin binding,structural molecule activity,protein...

photoreceptor inner segment,centrosome,centriole,c...

9

10

11

_LALLEEAR_.2|_AEVAEALTK_.2|_HSLATISLEMER_.3|_HSLAT...

SEN / CTL

Q99961

Endophilin-A2

SH3GL1

-0.45

0.26

0.000216

0.000228

signal transduction,central nervous system develop...

protein binding,lipid binding,phosphatase binding,...

podosome,cytoplasm,cell junction,early endosome me...

8

14

21

_AVTEVLAR_.2|_QAVQILDELAEK_.2|_TIEYLQPNPASR_.2|_AS...

SEN / CTL

O14737

Programmed cell death protein 5

PDCD5

-0.46

0.73

0.00000117

0.00000181

apoptotic process,negative regulation of cell prol...

DNA binding,protein binding,heparin binding,acetyl...

nucleus,cytoplasm,cytosol,extracellular exosome

32

9

16

_LSNLALVKPEK_.3|_LSNLALVKPEK_.2|_YGQLSEK_.2|_NSILA...

SEN / CTL

P26373

60S ribosomal protein L13

RPL13

-0.46

0.83

0.00000865

0.0000118

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytosol,membrane,cytosolic large ribosomal...

46

22

35

_STESLQANVQR_.2|_TIGISVDPR_.2|_GFSLEELR_.2|_VITEEE...

SEN / CTL

Q9Y3U8

60S ribosomal protein L36

RPL36

-0.46

0.35

0.0000958

0.000109

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleolus,cytoplasm,cytosol,membrane,cytosolic lar...

12

7

15

_EVC[+57]GFAPYER_.2|_YPMAVGLNK_.2|_YPM[+16]AVGLNK_...

SEN / CTL

Q9Y2D5

A-kinase anchor protein 2

AKAP2

-0.46

0.4

0.0031

0.00262

actin filament organization,transmembrane receptor...

protein kinase A binding

7

28

37

_YSEAAELR_.2|_LWAEDGEFTSAR_.2|_QVLQSTQSPR_.2|_MDDS...

SEN / CTL

P02533

Keratin, type I cytoskeletal 14

KRT14

-0.47

1.26

7.57e-9

1.66e-8

aging,epidermis development,response to zinc ion,r...

structural constituent of cytoskeleton,protein bin...

nucleus,cytoplasm,cytosol,intermediate filament,ke...

130

50

89

_LAADDFR_.2|_LASYLDK_.2|_VLDELTLAR_.2|_LASYLDKVR_....

SEN / CTL

P62851

40S ribosomal protein S25

RPS25

-0.47

0.43

9.98e-7

0.00000156

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,protein binding,poly(A) RNA binding

nucleus,nucleoplasm,nucleolus,cytosol,ribosome,sma...

23

11

13

_AQVIYTR_.2|_LITPAVVSER_.2|_AALQELLSK_.2|_NTKGGDAP...

SEN / CTL

Q96NY7

Chloride intracellular channel protein 6

CLIC6

-0.47

0.26

0.0000952

0.000109

regulation of ion transmembrane transport,chloride...

voltage-gated ion channel activity,chloride channe...

cytoplasm,plasma membrane,chloride channel complex...

8

13

16

_FLDGDELTLADC[+57]NLLPK_.2|_FLDGDELTLADC[+57]NLLPK...

SEN / CTL

P36578

60S ribosomal protein L4

RPL4

-0.48

0.63

2.38e-7

4.17e-7

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleolus,cytoplasm,cytosol,focal adhesion...

47

42

74

_AAAAAAALQAK_.2|_NVTLPAVFK_.2|_MINTDLSR_.2|_M[+16]...

SEN / CTL

P13647

Keratin, type II cytoskeletal 5

KRT5

-0.48

1.56

0.000124

0.000139

cytoskeleton organization,epidermis development,ke...

structural constituent of cytoskeleton,protein bin...

nucleus,cytoplasm,mitochondrion,cytosol,intermedia...

47

31

51

_ISISTSGGSFR_.2|_AQYEEIANR_.2|_YEELQQTAGR_.2|_TSFT...

SEN / CTL

P08758

Annexin A5

ANXA5

-0.48

1.62

0.027

0.0168

platelet degranulation,signal transduction,blood c...

phospholipase inhibitor activity,calcium ion bindi...

extracellular region,intracellular,cytoplasm,cytos...

172

45

70

_VLTEIIASR_.2|_GLGTDEESILTLLTSR_.2|_GLGTDEESILTLLT...

SEN / CTL

Q09666

Neuroblast differentiation-associated protein AHNAK

AHNAK

-0.49

1.08

4.47e-8

8.83e-8

regulation of RNA splicing,protein oligomerization...

RNA binding,protein binding,S100 protein binding,c...

nucleus,cytoplasm,lysosomal membrane,cytosol,plasm...

445

433

666

_ISMPDLDLNLKGPK_.3|_ISMPDLDLNLKGPK_.2|_SSGC[+57]DV...

SEN / CTL

O00299

Chloride intracellular channel protein 1

CLIC1

-0.5

0.69

1.66e-14

6.21e-14

chloride transport,signal transduction,regulation ...

voltage-gated ion channel activity,chloride channe...

extracellular space,nucleus,nuclear envelope,cytop...

151

24

42

_GFTIPEAFR_.2|_LAALNPESNTAGLDIFAK_.2|_LAALNPESNTAG...

SEN / CTL

P61247

40S ribosomal protein S3a

RPS3A

-0.5

0.92

4.26e-8

8.47e-8

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleoplasm,nucleolus,cytoplasm,endoplasmi...

72

30

55

_TTDGYLLR_.2|_LIPDSIGKDIEK_.3|_LIPDSIGKDIEK_.2|_LF...

SEN / CTL

P27635

60S ribosomal protein L10

RPL10

-0.5

0.16

0.00313

0.00265

ribosomal large subunit assembly,nuclear-transcrib...

RNA binding,structural constituent of ribosome,pro...

endoplasmic reticulum,cytosol,membrane,cytosolic l...

4

11

23

_MLSC[+57]AGADR_.2|_M[+16]LSC[+57]AGADR_.2|_GAFGKP...

SEN / CTL

P61353

60S ribosomal protein L27

RPL27

-0.51

0.69

0.0000258

0.0000329

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pol...

nucleus,cytosol,ribosome,focal adhesion,membrane,c...

29

11

19

_VVLVLAGR_.2|_YSVDIPLDK_.2|_VYNYNHLMPTR_.3|_VYNYNH...

SEN / CTL

P84098

60S ribosomal protein L19

RPL19

-0.53

0.36

0.000129

0.000143

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,focal adhesion,membrane,cytosolic large ri...

10

12

18

_LLADQAEAR_.2|_VWLDPNETNEIANANSR_.2|_VWLDPNETNEIAN...

SEN / CTL

Q16891

MICOS complex subunit MIC60

IMMT

-0.53

0.71

0.0938

0.049

biological_process,cristae formation,mitochondrial...

RNA binding,protein binding,poly(A) RNA binding

mitochondrion,mitochondrial inner membrane,membran...

3

79

130

_AFDSAVAK_.2|_SLEDALR_.2|_GVYSEETLR_.2|_FVNQLKGESR...

SEN / CTL

Q13576

Ras GTPase-activating-like protein IQGAP2

IQGAP2

-0.54

0.31

0.00145

0.0013

signal transduction,negative regulation of GTPase ...

actin binding,GTPase inhibitor activity,calmodulin...

cytoplasm,cytosol,plasma membrane,microvillus,cell...

8

88

113

_QLLAPVVK_.2|_ITLEDVISHSK_.3|_ITLEDVISHSK_.2|_HTDN...

SEN / CTL

Q9H299

SH3 domain-binding glutamic acid-rich-like protein 3

SH3BGRL3

-0.54

0.89

0.0419

0.0244

regulation of actin filament depolymerization,regu...

GTPase activator activity,electron carrier activit...

cytoplasm,nuclear body,lamellipodium,extracellular...

37

7

15

_VYSTSVTGSR_.2|_IQYQLVDISQDNALRDEMR_.3|_IQYQLVDISQ...

SEN / CTL

P35527

Keratin, type I cytoskeletal 9

KRT9

-0.55

1.71

8.87e-7

0.00000142

spermatogenesis,epidermis development,keratinizati...

structural constituent of cytoskeleton

extracellular space,nucleus,cytosol,intermediate f...

292

54

121

_TLLDIDNTR_.2|_MTLDDFR_.2|_M[+16]TLDDFR_.2|_QGVDAD...

SEN / CTL

P04264

Keratin, type II cytoskeletal 1

KRT1

-0.57

1.33

3.85e-13

1.27e-12

complement activation, lectin pathway,retina homeo...

receptor activity,structural molecule activity,pro...

extracellular region,extracellular space,nucleus,c...

479

63

114

_SISISVAR_.2|_TLLEGEESR_.2|_SLVNLGGSK_.2|_AQYEDIAQ...

SEN / CTL

Q86Y46

Keratin, type II cytoskeletal 73

KRT73

-0.57

1.07

0.0543

0.0304

biological_process,keratinization,cornification

molecular_function,structural molecule activity,pr...

nucleus,cytosol,keratin filament,extracellular exo...

13

3

4

_FLEQQNQVLETK_.2|_FLEQQNQVLETK_.3|_LSLDIEIATYRK_.3...

SEN / CTL

P55285

Cadherin-6

CDH6

-0.58

0.62

0.0000264

0.0000336

cell adhesion,homophilic cell adhesion via plasma ...

calcium ion binding

plasma membrane,integral component of membrane,ext...

21

12

12

_VEASNPYVEPR_.2|_IVVEDVDEPPVFSK_.2|_TPESSPPGTPIGR_...

SEN / CTL

P08779

Keratin, type I cytoskeletal 16

KRT16

-0.58

1.46

0.0003

0.000313

morphogenesis of an epithelium,inflammatory respon...

structural constituent of cytoskeleton,protein bin...

nucleus,cytosol,cytoskeleton,intermediate filament...

28

25

45

_APSTYGGGLSVSSR_.2|_DAETWFLSK_.2|_EVFTSSSSSSSR_.2|...

SEN / CTL

P61960

Ubiquitin-fold modifier 1

UFM1

-0.58

0.74

0.00217

0.00187

regulation of intracellular estrogen receptor sign...

protein binding

nucleus,cytoplasm,endoplasmic reticulum,extracellu...

11

5

9

_VLSVPESTPFTAVLK_.2|_VLSVPESTPFTAVLK_.3|_ITLTSDPR_...

SEN / CTL

O00469

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

PLOD2

-0.59

0.67

2.42e-9

5.59e-9

response to hypoxia,cellular protein modification ...

iron ion binding,procollagen-lysine 5-dioxygenase ...

endoplasmic reticulum,endoplasmic reticulum membra...

42

33

47

_SEDYVDIVQGNR_.2|_AC[+57]DELVEEMEHYGK_.3|_YLNSGGFI...

SEN / CTL

P04406

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

-0.6

1.24

2.16e-11

5.58e-11

microtubule cytoskeleton organization,gluconeogene...

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (p...

nucleus,cytoplasm,lipid particle,cytosol,plasma me...

291

51

166

_GALQNIIPASTGAAK_.2|_GALQNIIPASTGAAK_.3|_LISWYDNEF...

SEN / CTL

P26038

Moesin

MSN

-0.61

1.05

3.36e-12

9.7e-12

movement of cell or subcellular component,cytoskel...

double-stranded RNA binding,actin binding,receptor...

uropod,extracellular space,nucleus,cytoplasm,cytos...

343

58

108

_ALELEQER_.2|_SGYLAGDKLLPQR_.3|_SGYLAGDKLLPQR_.2|_...

SEN / CTL

P02538

Keratin, type II cytoskeletal 6A

KRT6A

-0.61

1.26

8.38e-10

1.96e-9

morphogenesis of an epithelium,cytoskeleton organi...

structural constituent of cytoskeleton,protein bin...

nucleus,cytosol,membrane,keratin filament,extracel...

147

61

85

_FLEQQNK_.2|_AQYEEIAQR_.2|_QLDSIVGER_.2|_WTLLQEQGT...

SEN / CTL

Q01469

Fatty acid-binding protein, epidermal

FABP5

-0.61

1.07

0.0172

0.0114

glucose metabolic process,lipid metabolic process,...

transporter activity,fatty acid binding,protein bi...

extracellular region,nucleoplasm,cytoplasm,cytosol...

20

17

34

_TTQFSC[+57]TLGEKFEETTADGRK_.4|_TTQFSC[+57]TLGEKFE...

SEN / CTL

P35555

Fibrillin-1

FBN1

-0.64

0.97

2.08e-14

7.52e-14

skeletal system development,metanephros developmen...

integrin binding,hormone activity,extracellular ma...

microfibril,extracellular region,proteinaceous ext...

210

32

32

_TLPGGNQC[+57]IVPIC[+57]R_.2|_GYILQEDGR_.2|_C[+57]...

SEN / CTL

Q16363

Laminin subunit alpha-4

LAMA4

-0.65

1.3

0.000023

0.0000297

cell adhesion,regulation of cell adhesion,extracel...

receptor binding,extracellular matrix structural c...

extracellular region,basement membrane,basal lamin...

70

42

51

_VDRDVEVEDFQR_.3|_AESSSDEAVADTSRR_.3|_C[+57]LDGYIG...

SEN / CTL

A6NCW0 A8MUK1 C9J2P7 C9JJH3 C9JLJ4 C9JPN9 C9JVI0 D6R901 D6R9N7 D6RA61 D6RBQ6 D6RCP7 D6RJB6 Q0WX57 Q7RTZ2

Ubiquitin carboxyl-terminal hydrolase 17-like protein 3;Ubiquitin carboxyl-terminal hydrolase 17-like protein 5;Ubiquitin carboxyl-terminal hydrolase 17-like protein 15;Ubiquitin carboxyl-terminal hydrolase 17-like protein 10;Ubiquitin carboxyl-terminal hydrolase 17-like protein 13;Ubiquitin carboxyl-terminal hydrolase 17-like protein 12;Ubiquitin carboxyl-terminal hydrolase 17-like protein 11;Ubiquitin carboxyl-terminal hydrolase 17-like protein 21;Ubiquitin carboxyl-terminal hydrolase 17-like protein 18;Ubiquitin carboxyl-terminal hydrolase 17-like protein 22;Ubiquitin carboxyl-terminal hydrolase 17-like protein 17;Ubiquitin carboxyl-terminal hydrolase 17-like protein 19;Ubiquitin carboxyl-terminal hydrolase 17-like protein 20;Ubiquitin carboxyl-terminal hydrolase 17-like protein 24;Ubiquitin carboxyl-terminal hydrolase 17-like protein 1

USP17L3 USP17L5 USP17L15 USP17L10 USP17L13 USP17L12 USP17L11 USP17L21 USP17L18 USP17L22 USP17L17 USP17L19 USP17L20 USP17L24 USP17L1

-0.65

0.35

0.00016

0.000174

ubiquitin-dependent protein catabolic process,apop...

thiol-dependent ubiquitinyl hydrolase activity;thi...

nucleus,endoplasmic reticulum;nucleus,endoplasmic ...

10

1

1

_FLQEQNK_.2

SEN / CTL

P23284

Peptidyl-prolyl cis-trans isomerase B

PPIB

-0.66

0.93

0.0153

0.0103

protein peptidyl-prolyl isomerization,positive reg...

RNA binding,peptidyl-prolyl cis-trans isomerase ac...

nucleus,endoplasmic reticulum,endoplasmic reticulu...

51

28

56

_IGDEDVGR_.2|_VLEGMEVVR_.2|_VLEGM[+16]EVVR_.2|_SIY...

SEN / CTL

P22692

Insulin-like growth factor-binding protein 4

IGFBP4

-0.69

0.48

1.07e-14

4.08e-14

skeletal system development,regulation of cell gro...

receptor binding,insulin-like growth factor I bind...

extracellular region,extracellular space

50

3

5

_THEDLYIIPIPNC[+57]DR_.3|_THEDLYIIPIPNC[+57]DR_.2|...

SEN / CTL

Q9BRA2

Thioredoxin domain-containing protein 17

TXNDC17

-0.69

1.57

0.00385

0.00318

tumor necrosis factor-mediated signaling pathway,o...

peroxidase activity,protein binding,protein-disulf...

cytosol,extracellular exosome

30

11

18

_VTAVPTLLK_.2|_SWC[+57]PDC[+57]VQAEPVVR_.2|_SWC[+5...

SEN / CTL

P02042 P02100 P68871 P69891 P69892

Hemoglobin subunit delta;Hemoglobin subunit epsilon;Hemoglobin subunit beta;Hemoglobin subunit gamma-1;Hemoglobin subunit gamma-2

HBD HBE1 HBB HBG1 HBG2

-0.69

0.64

0.00778

0.00578

blood coagulation,oxygen transport;blood coagulati...

oxygen transporter activity,iron ion binding,prote...

cytosol,hemoglobin complex,blood microparticle;cyt...

10

1

2

_LLVVYPWTQR_.2|_LLVVYPWTQR_.3

SEN / CTL

P15374

Ubiquitin carboxyl-terminal hydrolase isozyme L3

UCHL3

-0.69

0.45

0.0235

0.015

ubiquitin-dependent protein catabolic process,prot...

thiol-dependent ubiquitin-specific protease activi...

nucleus,cytoplasm,cytosol,extracellular exosome

6

15

26

_YLENYDAIR_.2|_WLPLEANPEVTNQFLK_.2|_WLPLEANPEVTNQF...

SEN / CTL

P62899

60S ribosomal protein L31

RPL31

-0.7

0.25

2.36e-10

5.75e-10

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,focal adhesion,membrane,cytosolic large ri...

19

13

16

_SAINEVVTR_.2|_EMGTPDVR_.2|_EM[+16]GTPDVR_.2|_NLQT...

SEN / CTL

Q02878

60S ribosomal protein L6

RPL6

-0.7

1.23

0.000178

0.000191

ribosomal large subunit assembly,nuclear-transcrib...

DNA binding,RNA binding,structural constituent of ...

nucleus,cytosol,focal adhesion,membrane,cytosolic ...

38

30

42

_AIPQLQGYLR_.2|_AVDSQILPK_.2|_YYPTEDVPR_.2|_FVIATS...

SEN / CTL

P15170

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

GSPT1

-0.7

0.17

0.0682

0.0376

G1/S transition of mitotic cell cycle,nuclear-tran...

RNA binding,translation release factor activity,GT...

intracellular,cytosol,translation release factor c...

4

36

61

_SVVAPPGAPK_.2|_FVKQDQVC[+57]IAR_.3|_TAGTIC[+57]LE...

SEN / CTL

O95447

Lebercilin-like protein

LCA5L

-0.71

0.2

0.0000012

0.00000183

protein binding

10

1

1

_QLAIETR_.2

SEN / CTL

P62979

Ubiquitin-40S ribosomal protein S27a

RPS27A

-0.72

0.71

4.94e-7

8.19e-7

G2/M transition of mitotic cell cycle,negative reg...

RNA binding,structural constituent of ribosome,pro...

extracellular space,nucleus,nucleoplasm,nucleolus,...

66

12

24

_TLSDYNIQK_.2|_ESTLHLVLR_.2|_TITLEVEPSDTIENVK_.2|_...

SEN / CTL

P08133

Annexin A6

ANXA6

-0.72

1.15

0.00000647

0.00000911

calcium ion transport,regulation of muscle contrac...

calcium ion binding,protein binding,GTP binding,ca...

mitochondrion,lysosomal membrane,focal adhesion,me...

114

72

121

_STPEYFAER_.2|_DAFVAIVQSVK_.2|_ALIEILATR_.2|_LVFDE...

SEN / CTL

O15511

Actin-related protein 2/3 complex subunit 5

ARPC5

-0.72

0.67

0.00176

0.00157

movement of cell or subcellular component,smooth m...

structural constituent of cytoskeleton,protein bin...

extracellular region,cytoplasm,endosome,cytosol,Ar...

10

13

23

_ALAAGGVGSIVR_.2|_QGNMTAALQAALKNPPINTK_.3|_GFESPSD...

SEN / CTL

P62917

60S ribosomal protein L8

RPL8

-0.74

0.42

4.19e-12

1.18e-11

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,5.8...

cytosol,focal adhesion,membrane,cytosolic large ri...

28

24

51

_AVVGVVAGGGR_.2|_AVDFAER_.2|_KVGLIAAR_.2|_KGAGSVFR...

SEN / CTL

P18124

60S ribosomal protein L7

RPL7

-0.74

0.74

0.00295

0.00251

nuclear-transcribed mRNA catabolic process, nonsen...

DNA binding,RNA binding,mRNA binding,structural co...

nucleus,nucleolus,cytoplasm,cytosol,polysome,focal...

14

24

42

_IALTDNALIAR_.2|_EVPAVPETLK_.2|_KKEVPAVPETLK_.3|_I...

SEN / CTL

P01344

Insulin-like growth factor II

IGF2

-0.74

0.81

0.02

0.013

skeletal system development,ossification,positive ...

insulin receptor binding,insulin-like growth facto...

extracellular region,extracellular space,plasma me...

19

2

3

_GIVEEC[+57]C[+57]FR_.2|_SC[+57]DLALLETYC[+57]ATPA...

SEN / CTL

Q9P246

Stromal interaction molecule 2

STIM2

-0.76

0.99

0.0292

0.018

store-operated calcium entry,cellular calcium ion ...

calcium channel regulator activity,calcium ion bin...

endoplasmic reticulum,endoplasmic reticulum membra...

10

15

17

_HITIEDLWK_.2|_RQYAEQELEQVR_.3|_RQYAEQELEQVR_.2|_E...

SEN / CTL

Q14112

Nidogen-2

NID2

-0.78

0.96

4.6e-22

2.94e-21

cell adhesion,cell-matrix adhesion,extracellular m...

calcium ion binding,protein binding,collagen bindi...

extracellular region,basement membrane,extracellul...

190

45

59

_VLYREDTSPAVLGLAAR_.3|_AIAVDPIR_.2|_ESYNVQLQLPAR_....

SEN / CTL

P50914

60S ribosomal protein L14

RPL14

-0.78

0.46

2.78e-8

5.6e-8

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,membrane,cytosolic large ribosomal subunit...

18

10

14

_LVAIVDVIDQNR_.2|_LVAIVDVIDQNR_.3|_ALVDGPC[+57]TQV...

SEN / CTL

P08253

72 kDa type IV collagenase

MMP2

-0.78

0.25

0.00000393

0.00000572

angiogenesis,response to hypoxia,blood vessel matu...

metalloendopeptidase activity,serine-type endopept...

extracellular region,proteinaceous extracellular m...

10

2

2

_IIGYTPDLDPETVDDAFAR_.2|_IDAVYEAPQEEK_.2

SEN / CTL

P02753

Retinol-binding protein 4

RBP4

-0.78

1.59

0.024

0.0152

retinoid metabolic process,eye development,glucone...

protein binding,retinal binding,retinol binding,re...

extracellular region,extracellular space,cytosol,p...

10

11

16

_QRQEELC[+57]LAR_.3|_QRQEELC[+57]LAR_.2|_YWGVASFLQ...

SEN / CTL

P35268

60S ribosomal protein L22

RPL22

-0.79

0.74

0.000728

0.000706

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytoplasm,cytosol,focal adhesion,cytosolic...

11

7

15

_AGNLGGGVVTIER_.2|_AGNLGGGVVTIER_.3|_VVANSKESYELR_...

SEN / CTL

P02768

Serum albumin

ALB

-0.79

1.98

0.0464

0.0267

retina homeostasis,platelet degranulation,transpor...

DNA binding,fatty acid binding,copper ion binding,...

extracellular region,extracellular space,nucleus,e...

69

107

232

_KVPQVSTPTLVEVSR_.3|_KVPQVSTPTLVEVSR_.2|_KVPQVSTPT...

SEN / CTL

P06703

Protein S100-A6

S100A6

-0.81

0.44

8.64e-19

4.47e-18

signal transduction,axonogenesis,ion transmembrane...

calcium ion binding,protein binding,tropomyosin bi...

ruffle,nucleus,nuclear envelope,cytoplasm,cytosol,...

59

12

14

_LQDAEIAR_.2|_ELIQKELTIGSK_.3|_ELIQKELTIGSK_.2|_EL...

SEN / CTL

P05155

Plasma protease C1 inhibitor

SERPING1

-0.81

0.69

5e-9

1.1e-8

negative regulation of complement activation, lect...

serine-type endopeptidase inhibitor activity,prote...

extracellular region,extracellular space,platelet ...

19

19

34

_LLDSLPSDTR_.2|_TLYSSSPR_.2|_FQPTLLTLPR_.2|_LVLLNA...

SEN / CTL

O60884

DnaJ homolog subfamily A member 2

DNAJA2

-0.81

0.04

0.000621

0.000607

positive regulation of cell proliferation,response...

ATPase activator activity,protein binding,ATP bind...

cytosol,membrane,extracellular exosome

3

22

31

_VIEPGC[+57]VR_.2|_NVLC[+57]SAC[+57]SGQGGK_.2|_NVL...

SEN / CTL

P40227

T-complex protein 1 subunit zeta

CCT6A

-0.83

1.34

0.00833

0.00611

protein folding,'de novo' protein folding,positive...

RNA binding,protein binding,ATP binding,protein bi...

cytoplasm,cytosol,chaperonin-containing T-complex,...

49

42

77

_GIDPFSLDALSK_.2|_IITEGFEAAKEK_.3|_GLQDVLR_.2|_IIT...

SEN / CTL

P08729

Keratin, type II cytoskeletal 7

KRT7

-0.84

0.98

0.0195

0.0127

viral process,keratinization,cornification

structural molecule activity,protein binding

nucleus,cytoplasm,cytosol,intermediate filament,ke...

11

50

74

_LALDIEIATYR_.2|_LQAEIDNIK_.2|_DVDAAYMSK_.2|_DVDAA...

SEN / CTL

P62424

60S ribosomal protein L7a

RPL7A

-0.85

1.21

0.000445

0.000445

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,nucleolus,cytoplasm,cytosol,focal adhesion...

17

31

43

_VAPAPAVVK_.2|_AGVNTVTTLVENK_.2|_AGVNTVTTLVENK_.3|...

SEN / CTL

P35900

Keratin, type I cytoskeletal 20

KRT20

-0.85

1.39

0.0539

0.0303

apoptotic process,keratinization,cellular response...

structural constituent of cytoskeleton,protein bin...

cytoplasm,cytosol,intermediate filament

8

37

60

_MAMQNLNDR_.2|_MAM[+16]QNLNDR_.2|_M[+16]AMQNLNDR_....

SEN / CTL

Q8WUM4

Programmed cell death 6-interacting protein

PDCD6IP

-0.87

1.01

0.00000113

0.00000176

actomyosin contractile ring assembly,cell separati...

protein binding,proteinase activated receptor bind...

immunological synapse,microtubule organizing cente...

53

63

96

_STPVNVPISQK_.2|_LALASLGYEK_.2|_EVFPVLAAK_.2|_FYNE...

SEN / CTL

Q9NZN4

EH domain-containing protein 2

EHD2

-0.87

1.32

0.0955

0.0498

endocytosis,blood coagulation,cortical actin cytos...

nucleic acid binding,calcium ion binding,protein b...

nucleus,cytosol,plasma membrane,caveola,endosome m...

23

30

46

_GYDFPAVLR_.2|_LEGHGLPANLPR_.3|_LEGHGLPANLPR_.2|_G...

SEN / CTL

P10909

Clusterin

CLU

-0.88

0.52

5.22e-37

5.4e-36

cell morphogenesis,microglial cell activation,rele...

protein binding,ubiquitin protein ligase binding,c...

extracellular region,extracellular space,nucleus,c...

161

25

42

_LFDSDPITVTVPVEVSR_.2|_LFDSDPITVTVPVEVSR_.3|_ASSII...

SEN / CTL

Q9UBR2

Cathepsin Z

CTSZ

-0.89

0.34

3.49e-21

2.1e-20

angiotensin maturation,proteolysis,ER to Golgi ves...

cysteine-type endopeptidase activity,protein bindi...

Golgi membrane,extracellular region,extracellular ...

43

16

25

_NSWGEPWGER_.2|_VGDYGSLSGR_.2|_STYPRPHEYLSPADLPK_....

SEN / CTL

O15031

Plexin-B2

PLXNB2

-0.9

0.34

0.0872

0.0465

neural tube closure,regulation of protein phosphor...

protein binding,semaphorin receptor activity

integral component of plasma membrane,cell surface...

2

52

71

_FGAQLQC[+57]VTGPQATR_.3|_FGAQLQC[+57]VTGPQATR_.2|...

SEN / CTL

P61313

60S ribosomal protein L15

RPL15

-0.92

0.41

2.84e-9

6.5e-9

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

nucleus,cytosol,ribosome,membrane,cytosolic large ...

20

16

23

_SLQSVAEER_.2|_QGYVIYR_.2|_YIQELWR_.2|_RNPDTQWITK_...

SEN / CTL

Q01518

Adenylyl cyclase-associated protein 1

CAP1

-0.93

1.17

5.1e-11

1.31e-10

cell morphogenesis,ameboidal-type cell migration,r...

actin binding,adenylate cyclase binding

extracellular region,extracellular space,plasma me...

128

52

100

_NSLDC[+57]EIVSAK_.2|_C[+57]VNTTLQIK_.2|_QVAYIYK_....

SEN / CTL

Q08431

Lactadherin

MFGE8

-0.97

0.81

8.57e-19

4.47e-18

angiogenesis,phagocytosis, recognition,phagocytosi...

phosphatidylserine binding,integrin binding,phosph...

extracellular region,extracellular space,external ...

85

15

19

_EVTGIITQGAR_.2|_NLFETPILAR_.2|_MWVTGVVTQGASR_.2|_...

SEN / CTL

Q07020

60S ribosomal protein L18

RPL18

-0.98

0.54

5.17e-7

8.52e-7

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome

nucleus,nucleolus,endoplasmic reticulum,cytosol,fo...

15

14

20

_ILTFDQLALDSPK_.2|_GC[+57]GTVLLSGPR_.2|_SQDIYLR_.2...

SEN / CTL

P21810

Biglycan

BGN

-0.99

1.19

6.18e-17

2.73e-16

blood vessel remodeling,negative regulation of pro...

protein kinase inhibitor activity,extracellular ma...

extracellular region,proteinaceous extracellular m...

99

23

37

_VPSGLPDLK_.2|_VVQC[+57]SDLGLK_.2|_LAIQFGNYK_.2|_I...

SEN / CTL

Q14114

Low-density lipoprotein receptor-related protein 8

LRP8

-0.99

0.29

0.00000202

0.00000302

negative regulation of transcription from RNA poly...

transmembrane signaling receptor activity,low-dens...

extracellular region,microtubule associated comple...

10

1

1

_AIAVDPLR_.2

SEN / CTL

Q9Y646

Carboxypeptidase Q

CPQ

-0.99

0.5

0.0202

0.0131

proteolysis,thyroid hormone generation,tissue rege...

carboxypeptidase activity,protein homodimerization...

extracellular space,cytoplasm,lysosome,endoplasmic...

4

10

10

_VGALASLIR_.2|_LALLVDTVGPR_.2|_AIINLAVYGK_.2|_VHLE...

SEN / CTL

P15311

Ezrin

EZR

-1.01

0.63

6.44e-12

1.76e-11

negative regulation of transcription from RNA poly...

RNA binding,actin binding,protein binding,microtub...

fibrillar center,ruffle,immunological synapse,urop...

83

50

90

_SGYLSSER_.2|_ELSEQIQR_.2|_QRIDEFEAL_.2|_IALLEEAR_...

SEN / CTL

Q12841

Follistatin-related protein 1

FSTL1

-1.01

0.86

8.38e-12

2.25e-11

BMP signaling pathway,response to starvation

calcium ion binding,protein binding,heparin bindin...

extracellular region,extracellular space,extracell...

68

12

12

_IC[+57]ANVFC[+57]GAGR_.2|_C[+57]LNPSFNPPEKK_.3|_L...

SEN / CTL

O43852

Calumenin

CALU

-1.04

0.79

1.34e-18

6.8e-18

biological_process

calcium ion binding,protein binding

extracellular region,endoplasmic reticulum,endopla...

98

34

62

_WIYEDVER_.2|_EQFVEFR_.2|_TFDQLTPEESKER_.3|_IDGDKD...

SEN / CTL

Q15907

Ras-related protein Rab-11B

RAB11B

-1.07

0.48

6.05e-13

1.89e-12

receptor recycling,small GTPase mediated signal tr...

GTPase activity,protein binding,GTP binding,GDP bi...

mitochondrion,cytosol,synaptic vesicle,cell juncti...

28

15

23

_AQIWDTAGQER_.2|_VVLIGDSGVGK_.2|_STIGVEFATR_.2|_GA...

SEN / CTL

P02774

Vitamin D-binding protein

GC

-1.07

1.6

0.00201

0.00175

vitamin D metabolic process,vitamin transport

actin binding,vitamin D binding,vitamin transporte...

extracellular region,extracellular space,cytosol,l...

50

46

77

_LC[+57]DNLSTK_.2|_HQPQEFPTYVEPTNDEIC[+57]EAFRKDPK...

SEN / CTL

P62195

26S protease regulatory subunit 8

PSMC5

-1.07

0.75

0.00408

0.00332

MAPK cascade,protein polyubiquitination,stimulator...

transcription cofactor activity,protein binding,AT...

proteasome complex,nucleus,nucleoplasm,cytoplasm,c...

10

32

57

_GVLLYGPPGTGK_.2|_VIMATNR_.2|_FVVDVDKNIDINDVTPNC[+...

SEN / CTL

Q92820

Gamma-glutamyl hydrolase

GGH

-1.08

0.72

9.47e-8

1.74e-7

proteolysis,glutamine metabolic process,response t...

exopeptidase activity,omega peptidase activity,gam...

extracellular region,extracellular space,nucleus,c...

22

19

26

_YLESAGAR_.2|_YYIAASYVK_.2|_NLDGISHAPNAVK_.3|_NLDG...

SEN / CTL

Q9C037

E3 ubiquitin-protein ligase TRIM4

TRIM4

-1.08

1.23

0.0455

0.0263

protein ubiquitination,innate immune response,prot...

zinc ion binding,transferase activity,ligase activ...

cytoplasm,cytosol,plasma membrane

9

11

13

_KVM[+16]HLQDVEVK_.2|_KVMHLQDVEVK_.3|_RFQVAVNLAEDT...

SEN / CTL

Q8WTW3

Conserved oligomeric Golgi complex subunit 1

COG1

-1.1

1

0.0171

0.0113

ER to Golgi vesicle-mediated transport,intra-Golgi...

protein binding

Golgi membrane,Golgi apparatus,Golgi transport com...

10

27

36

_LLLEIPEK_.2|_TLAHPISQEYLK_.3|_TLAHPISQEYLK_.2|_C[...

SEN / CTL

Q9BXP5

Serrate RNA effector molecule homolog

SRRT

-1.1

1.1

0.0412

0.0242

mRNA splicing, via spliceosome,regulation of trans...

DNA binding,RNA binding,protein binding,nucleotide...

nucleoplasm,cytoplasm

4

47

64

_NIAPNISR_.2|_LTPLLSVR_.2|_MLDAAVIK_.2|_AGAGLGDGER...

SEN / CTL

P00747

Plasminogen

PLG

-1.12

0.61

0.0109

0.00772

platelet degranulation,proteolysis,blood coagulati...

serine-type endopeptidase activity,receptor bindin...

extracellular region,extracellular space,plasma me...

5

58

96

_TPENFPC[+57]K_.2|_KDIALLK_.2|_RAPWC[+57]HTTNSQVR_...

SEN / CTL

Q99584

Protein S100-A13

S100A13

-1.12

0.15

0.0456

0.0263

positive regulation of cell proliferation,regulati...

copper ion binding,calcium ion binding,protein bin...

extracellular space,nucleus,nucleolus,cytoplasm,cy...

2

9

13

_DVGSLDEK_.2|_SLDVNQDSELKFNEYWR_.3|_DSLSVNEFK_.2|_...

SEN / CTL

P40261

Nicotinamide N-methyltransferase

NNMT

-1.12

1.13

0.0595

0.0331

response to organonitrogen compound,animal organ r...

nicotinamide N-methyltransferase activity,pyridine...

cytosol

5

13

20

_HSAESQILK_.2|_DTYLSHFNPR_.3|_DTYLSHFNPR_.2|_IFC[+...

SEN / CTL

P01008

Antithrombin-III

SERPINC1

-1.13

0.62

8.5e-7

0.00000138

acute inflammatory response to antigenic stimulus,...

protease binding,serine-type endopeptidase inhibit...

extracellular region,extracellular space,plasma me...

19

31

70

_LPGIVAEGR_.2|_RVWELSK_.2|_LQPLDFK_.2|_TSDQIHFFFAK...

SEN / CTL

Q9UBX5

Fibulin-5

FBLN5

-1.15

0.4

5.58e-20

3.16e-19

regulation of cell growth,cell-matrix adhesion,ext...

integrin binding,calcium ion binding,protein bindi...

extracellular region,proteinaceous extracellular m...

36

9

10

_YPGAYYIFQIK_.2|_DMDVVSGR_.2|_DQPFTILYR_.2|_QSGQC[...

SEN / CTL

Q92882

Osteoclast-stimulating factor 1

OSTF1

-1.15

0.11

0.0046

0.00363

ossification,signal transduction,neutrophil degran...

protein binding,SH3 domain binding

extracellular region,intracellular,secretory granu...

3

13

23

_GNLSWLR_.2|_ALYTFEPR_.2|_LAFDMATNAAC[+57]ASLLK_.2...

SEN / CTL

P08697

Alpha-2-antiplasmin

SERPINF2

-1.15

1.18

0.00967

0.00694

regulation of blood vessel size by renin-angiotens...

protease binding,endopeptidase inhibitor activity,...

extracellular region,fibrinogen complex,extracellu...

11

20

29

_LC[+57]QDLGPGAFR_.2|_DFLQSLK_.2|_NKFDPSLTQR_.3|_L...

SEN / CTL

Q9Y3A4

Ribosomal RNA-processing protein 7 homolog A

RRP7A

-1.16

0.41

0.00445

0.00356

ribosomal small subunit assembly,blastocyst format...

nucleotide binding,RNA binding,protein binding,pol...

nucleoplasm,cytoplasm,CURI complex,UTP-C complex

5

10

12

_ELLNFYAWQHR_.2|_ELLNFYAWQHR_.3|_QQASHYLYVR_.3|_GP...

SEN / CTL

Q4G0J3

La-related protein 7

LARP7

-1.16

0.57

0.0107

0.00759

RNA processing

nucleotide binding,RNA binding,protein binding,pol...

nucleoplasm,cytosol,intracellular ribonucleoprotei...

4

25

31

_QVLADIAK_.2|_IISTEPLPGRK_.3|_LEILSGDHEQR_.3|_LEIL...

SEN / CTL

Q02543

60S ribosomal protein L18a

RPL18A

-1.16

0.19

0.0415

0.0243

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,structural constituent of ribosome,pro...

cytosol,membrane,cytosolic large ribosomal subunit

3

17

25

_EYRDLTTAGAVTQC[+57]YR_.3|_DLTTAGAVTQC[+57]YR_.2|_...

SEN / CTL

Q9Y6C2

EMILIN-1

EMILIN1

-1.17

1.21

8.37e-17

3.64e-16

cell adhesion

protein binding,extracellular matrix constituent c...

extracellular region,proteinaceous extracellular m...

116

36

48

_GVLQGLSGR_.2|_LAEDVQR_.2|_LLASVEER_.2|_LVGGQAGLGR...

SEN / CTL

Q15113

Procollagen C-endopeptidase enhancer 1

PCOLCE

-1.17

1.15

3.36e-7

5.77e-7

proteolysis,multicellular organism development,pos...

protein binding,collagen binding,heparin binding,p...

extracellular space,extracellular exosome,extracel...

53

9

10

_TGGLDLPSPPTGASLK_.2|_YDALEVFAGSGTSGQR_.2|_MTTDEGT...

SEN / CTL

P05976 P08590

Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3

MYL1 MYL3

-1.18

0.31

0.000778

0.00075

muscle contraction,muscle filament sliding,cardiac...

calcium ion binding,structural constituent of musc...

cytosol,muscle myosin complex,myofibril,sarcomere;...

5

1

3

_VFDKEGNGTVMGAELR_.3|_VFDKEGNGTVMGAELR_.2|_VFDKEGN...

SEN / CTL

P07602

Prosaposin

PSAP

-1.19

0.82

7.75e-39

8.61e-38

platelet degranulation,glycosphingolipid metabolic...

G-protein coupled receptor binding,protein binding...

extracellular region,extracellular space,mitochond...

170

30

59

_LVGYLDR_.2|_GSAVWC[+57]QNVK_.2|_DGGFC[+57]EVC[+57...

SEN / CTL

Q02750

Dual specificity mitogen-activated protein kinase kinase 1

MAP2K1

-1.19

0.9

0.0159

0.0106

MAPK cascade,activation of MAPK activity,movement ...

protein kinase activity,protein serine/threonine k...

nucleus,mitochondrion,early endosome,late endosome...

5

23

34

_IPEQILGK_.2|_KLEELELDEQQR_.3|_KLEELELDEQQR_.2|_SY...

SEN / CTL

P01024

Complement C3

C3

-1.2

0.77

0.000172

0.000186

positive regulation of type IIa hypersensitivity,p...

serine-type endopeptidase activity,endopeptidase i...

extracellular region,extracellular space,plasma me...

20

130

202

_NEQVEIR_.2|_AC[+57]EPGVDYVYK_.2|_KGYTQQLAFR_.3|_K...

SEN / CTL

P11047

Laminin subunit gamma-1

LAMC1

-1.21

1.15

2.56e-50

5.13e-49

protein complex assembly,cell adhesion,endoderm de...

extracellular matrix structural constituent

extracellular region,basement membrane,laminin-1 c...

273

77

97

_AFDITYVR_.2|_NTIEETGNLAEQAR_.2|_NTIEETGNLAEQAR_.3...

SEN / CTL

Q6UXS9

Inactive caspase-12

CASP12

-1.21

0.48

0.0000108

0.0000145

endoplasmic reticulum unfolded protein response,re...

cysteine-type endopeptidase activity involved in a...

endoplasmic reticulum,IPAF inflammasome complex,NL...

11

1

2

_AGADTHGRLLQGNIC[+57]NDAVTK_.3|_AGADTHGRLLQGNIC[+5...

SEN / CTL

P29279

Connective tissue growth factor

CTGF

-1.22

1.42

0.00109

0.00102

cartilage condensation,ossification,angiogenesis,r...

fibronectin binding,integrin binding,protein bindi...

extracellular region,proteinaceous extracellular m...

26

8

8

_DGAPC[+57]IFGGTVYR_.2|_SGESFQSSC[+57]K_.2|_C[+57]...

SEN / CTL

P02787

Serotransferrin

TF

-1.23

0.75

0.000081

0.0000942

retina homeostasis,platelet degranulation,cellular...

protein binding,ferrous iron binding,ferric iron b...

extracellular region,extracellular space,early end...

14

86

160

_C[+57]LVEKGDVAFVK_.3|_C[+57]LVEKGDVAFVK_.2|_DGAGD...

SEN / CTL

Q9NVN3

Synembryn-B

RIC8B

-1.24

0.5

0.00357

0.00297

regulation of G-protein coupled receptor protein s...

G-protein alpha-subunit binding,guanyl-nucleotide ...

centrosome,cytosol,plasma membrane,cell cortex,cyt...

5

1

1

_GSSYREGLTPVLSLLTEC[+57]SR_.3

SEN / CTL

P40429

60S ribosomal protein L13a

RPL13A

-1.24

0.51

0.00402

0.00328

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,mRNA binding,structural constituent of...

nucleus,nucleolus,cytoplasm,cytosol,focal adhesion...

5

13

15

_YQAVTATLEEK_.2|_C[+57]EGINISGNFYR_.2|_KIDKYTEVLK_...

SEN / CTL

Q96FQ6

Protein S100-A16

S100A16

-1.24

1.24

0.00418

0.00337

response to calcium ion

RNA binding,calcium ion binding,protein binding,pr...

nucleolus,cytosol,plasma membrane,extracellular ex...

19

8

13

_LIHEQEQQSSS_.2|_AVIVLVENFYK_.2|_AVIVLVENFYK_.3|_A...

SEN / CTL

Q9BY43

Charged multivesicular body protein 4a

CHMP4A

-1.25

0.56

0.00103

0.000973

cell separation after cytokinesis,posttranslationa...

protein binding,lipid binding,identical protein bi...

ESCRT III complex,nucleus,cytoplasm,cytosol,cytopl...

8

11

12

_FEQQLAQTDGTLSTLEFQR_.3|_FEQQLAQTDGTLSTLEFQR_.2|_E...

SEN / CTL

P49915

GMP synthase [glutamine-hydrolyzing]

GMPS

-1.25

0.37

0.00271

0.00232

GMP biosynthetic process,glutamine metabolic proce...

GMP synthase activity,GMP synthase (glutamine-hydr...

cytosol,cytoplasm

6

55

95

_LENAGGDLK_.2|_SGNIVAGIANESK_.2|_RESQSVEEALK_.3|_R...

SEN / CTL

Q9H0U4

Ras-related protein Rab-1B

RAB1B

-1.26

2

0.0239

0.0152

ER to Golgi vesicle-mediated transport,retrograde ...

protein binding,GTP binding

Golgi membrane,mitochondrion,endoplasmic reticulum...

30

17

31

_LLLIGDSGVGK_.2|_TITSSYYR_.2|_LQIWDTAGQER_.2|_LQIW...

SEN / CTL

Q9NRG9

Aladin

AAAS

-1.28

0.58

0.00179

0.00159

mRNA export from nucleus,tRNA export from nucleus,...

molecular_function

nucleus,nuclear envelope,nuclear pore,nucleoplasm,...

7

20

25

_SATIVADLSETTIQTPDGEER_.3|_SATIVADLSETTIQTPDGEER_....

SEN / CTL

Q9C0H2

Protein tweety homolog 3

TTYH3

-1.28

0.56

0.00422

0.00339

chloride transport,ion transmembrane transport,chl...

intracellular calcium activated chloride channel a...

plasma membrane,chloride channel complex,extracell...

5

7

9

_TVAGVQDR_.2|_ALVEMQDVVAELLR_.2|_ALVEMQDVVAELLR_.3...

SEN / CTL

Q9H082

Ras-related protein Rab-33B

RAB33B

-1.29

1.04

0.00604

0.00465

protein targeting to Golgi,intra-Golgi vesicle-med...

GTPase activity,protein binding,GTP binding

Golgi membrane,Golgi apparatus,Golgi lumen,extrace...

10

4

5

_IQLWDTAGQER_.2|_IKIQLWDTAGQER_.3|_IKIQLWDTAGQER_....

SEN / CTL

P59190

Ras-related protein Rab-15

RAB15

-1.29

1.07

0.0072

0.00539

vesicle docking involved in exocytosis,small GTPas...

protein binding,GTP binding

cytoplasm,plasma membrane,cilium,endosome membrane...

10

1

1

_IQIWDTAGQER_.2

SEN / CTL

Q9Y4K0

Lysyl oxidase homolog 2

LOXL2

-1.3

1.01

5.29e-11

1.34e-10

response to hypoxia,epithelial to mesenchymal tran...

chromatin binding,transcription corepressor activi...

basement membrane,extracellular space,nucleus,nucl...

52

16

19

_VVC[+57]GMFGFPGER_.2|_LGQGIGPIHLNEIQC[+57]TGNEK_....

SEN / CTL

P80303

Nucleobindin-2

NUCB2

-1.3

0.75

2.01e-7

3.56e-7

DNA binding,calcium ion binding,protein binding

extracellular space,nuclear envelope,endoplasmic r...

21

26

37

_LVTLEEFLK_.2|_QVIDVLETDKHFR_.3|_ADIEEIK_.2|_VQNIH...

SEN / CTL

P12109

Collagen alpha-1(VI) chain

COL6A1

-1.35

1.17

2.2e-49

4.13e-48

osteoblast differentiation,cell adhesion,extracell...

platelet-derived growth factor binding

extracellular region,proteinaceous extracellular m...

319

49

69

_VPSYQALLR_.2|_VFSVAITPDHLEPR_.3|_VFSVAITPDHLEPR_....

SEN / CTL

O43237

Cytoplasmic dynein 1 light intermediate chain 2

DYNC1LI2

-1.36

0.12

0.0812

0.0436

microtubule cytoskeleton organization,ER to Golgi ...

microtubule motor activity,ATP binding,dynein heav...

centrosome,cytosol,cytoplasmic dynein complex,micr...

2

28

36

_TVLSNVQEELDR_.2|_NLDLLYK_.2|_ELAAEDEQVFLMK_.3|_EL...

SEN / CTL

Q93063

Exostosin-2

EXT2

-1.37

0.47

0.019

0.0125

ossification,mesoderm formation,glycosaminoglycan ...

protein binding,glucuronosyltransferase activity,t...

Golgi membrane,endoplasmic reticulum,endoplasmic r...

4

7

7

_ALLAGGGFSTWTYR_.2|_YFNYLYTYK_.2|_FASVFGTMPLK_.2|_...

SEN / CTL

Q92626

Peroxidasin homolog

PXDN

-1.38

1.35

4.72e-26

3.46e-25

negative regulation of cytokine-mediated signaling...

peroxidase activity,interleukin-1 receptor antagon...

proteinaceous extracellular matrix,extracellular s...

168

30

36

_IVNEGGIDPLLR_.2|_AEGNPKPEIIWLR_.3|_SPNDLLALFR_.2|...

SEN / CTL

P07355

Annexin A2

ANXA2

-1.41

1.12

1.29e-53

2.98e-52

angiogenesis,membrane raft assembly,positive regul...

protease binding,RNA binding,calcium ion binding,p...

ruffle,extracellular region,basement membrane,extr...

346

49

99

_GLGTDEDSLIEIIC[+57]SR_.2|_GLGTDEDSLIEIIC[+57]SR_....

SEN / CTL

P19823

Inter-alpha-trypsin inhibitor heavy chain H2

ITIH2

-1.41

2.11

1.1e-8

2.32e-8

negative regulation of endopeptidase activity,hyal...

endopeptidase inhibitor activity,serine-type endop...

extracellular region,extracellular exosome,blood m...

66

38

62

_IQPSGGTNINEALLR_.2|_VQSTITSR_.2|_FYNQVSTPLLR_.2|_...

SEN / CTL

P61106

Ras-related protein Rab-14

RAB14

-1.41

0.3

0.0131

0.0091

phosphatidylinositol biosynthetic process,Golgi to...

GTPase activity,protein binding,GTP binding,GDP bi...

Golgi membrane,intracellular,lysosome,lysosomal me...

3

21

36

_IIEVSGQK_.2|_YIIIGDMGVGK_.2|_YIIIGDM[+16]GVGK_.2|...

SEN / CTL

P14543

Nidogen-1

NID1

-1.43

0.94

6.82e-37

6.6e-36

cell-matrix adhesion,positive regulation of cell-s...

calcium ion binding,collagen binding,laminin bindi...

extracellular region,basement membrane,basal lamin...

157

39

51

_GIVTDSVR_.2|_VYYREDLSPSITQR_.3|_VLFETDLVNPR_.2|_Y...

SEN / CTL

Q02952

A-kinase anchor protein 12

AKAP12

-1.43

1.45

0.0313

0.0192

protein targeting,G-protein coupled receptor signa...

protein binding,adenylate cyclase binding,protein ...

cytoplasm,cytosol,cytoskeleton,plasma membrane,foc...

9

84

109

_STPVIVSATTK_.2|_VKEESQLPGTGGPEDVLQPVQR_.3|_LVQNII...

SEN / CTL

Q07954

Prolow-density lipoprotein receptor-related protein 1

LRP1

-1.47

0.36

1.45e-21

8.87e-21

retinoid metabolic process,receptor-mediated endoc...

protease binding,RNA binding,receptor activity,low...

nucleolus,lysosomal membrane,endosome,cytosol,plas...

32

65

72

_LDGLC[+57]IPLR_.2|_YVVISQGLDKPR_.3|_GVGGAPPTVTLLR...

SEN / CTL

P20340

Ras-related protein Rab-6A

RAB6A

-1.47

1.07

0.00459

0.00363

protein targeting to Golgi,retrograde vesicle-medi...

GTPase activity,protein binding,GTP binding,protei...

Golgi membrane,endoplasmic reticulum membrane,Golg...

10

12

15

_LQLWDTAGQER_.2|_SLIPSYIR_.2|_RQVSIEEGERK_.3|_RQVS...

SEN / CTL

P27105

Erythrocyte band 7 integral membrane protein

STOM

-1.47

1

0.00899

0.0065

neutrophil degranulation,positive regulation by ho...

protein binding,protein homodimerization activity,...

extracellular space,mitochondrion,endoplasmic reti...

6

20

38

_LLAQTTLR_.2|_LPVQLQR_.2|_AMAAEAEASR_.2|_AM[+16]AA...

SEN / CTL

Q8N9P6

Uncharacterized protein C9orf163

C9orf163

-1.47

0.4

0.0205

0.0133

3

1

1

_EGVISVPR_.2

SEN / CTL

Q08380

Galectin-3-binding protein

LGALS3BP

-1.48

1.43

9.76e-31

8.61e-30

platelet degranulation,receptor-mediated endocytos...

scavenger receptor activity

extracellular region,proteinaceous extracellular m...

206

23

30

_SDLAVPSELALLK_.2|_ASHEEVEGLVEK_.3|_ASHEEVEGLVEK_....

SEN / CTL

P02788

Lactotransferrin

LTF

-1.49

1.55

0.000212

0.000226

ossification,regulation of cytokine production,ret...

DNA binding,serine-type endopeptidase activity,iro...

extracellular region,extracellular space,nucleus,c...

23

76

117

_YYGYTGAFR_.2|_C[+57]GLVPVLAENYK_.2|_C[+57]LAENAGD...

SEN / CTL

P04083

Annexin A1

ANXA1

-1.5

1.02

5.35e-38

5.73e-37

DNA strand renaturation,neutrophil homeostasis,ada...

single-stranded DNA binding,single-stranded RNA bi...

cornified envelope,phagocytic cup,extracellular re...

167

38

69

_ALYEAGER_.2|_NALLSLAK_.2|_DLAKDITSDTSGDFR_.3|_DLA...

SEN / CTL

P50897

Palmitoyl-protein thioesterase 1

PPT1

-1.5

0.6

0.0116

0.00813

protein depalmitoylation,receptor-mediated endocyt...

protein binding,palmitoyl-(protein) hydrolase acti...

extracellular region,extracellular space,nucleus,l...

9

14

39

_ETIPLQETSLYTQDR_.2|_ETIPLQETSLYTQDR_.3|_TLNAGAYSK...

SEN / CTL

Q99519

Sialidase-1

NEU1

-1.52

0.21

0.00669

0.00508

glycosphingolipid metabolic process,ganglioside ca...

exo-alpha-sialidase activity,protein binding,exo-a...

extracellular region,lysosome,lysosomal membrane,p...

3

10

14

_GTLLAFAEAR_.2|_QIGSVDTFRIPLITATPR_.3|_IPLITATPR_....

SEN / CTL

Q02818

Nucleobindin-1

NUCB1

-1.53

0.91

1.66e-58

4.97e-57

response to cisplatin,regulation of protein target...

G-protein alpha-subunit binding,DNA binding,calciu...

extracellular space,nucleus,early endosome,rough e...

217

33

46

_LSQETEALGR_.2|_ELQQAVLHMEQR_.3|_ELQQAVLHMEQR_.2|_...

SEN / CTL

P51149

Ras-related protein Rab-7a

RAB7A

-1.54

0.96

3.23e-16

1.39e-15

protein targeting to lysosome,endocytosis,epiderma...

GTPase activity,protein binding,GTP binding,GDP bi...

autophagosome membrane,lysosome,lysosomal membrane...

54

23

34

_VIILGDSGVGK_.2|_FQSLGVAFYR_.2|_ATIGADFLTK_.2|_AQA...

SEN / CTL

Q9BRK3

Matrix-remodeling-associated protein 8

MXRA8

-1.54

1.4

0.0151

0.0103

establishment of glial blood-brain barrier

molecular_function

cell surface,integral component of membrane,extrac...

10

2

2

_GAPALLTC[+57]VNR_.2|_ERAELAHSPLPAK_.3

SEN / CTL

P07942

Laminin subunit beta-1

LAMB1

-1.56

1.14

3.54e-49

6.25e-48

cell adhesion,neuronal-glial interaction involved ...

structural molecule activity,extracellular matrix ...

extracellular region,basement membrane,laminin-1 c...

248

76

100

_TFRPAAMLIER_.3|_GALDSITK_.2|_TLLAQANSK_.2|_IPSWTG...

SEN / CTL

P23142

Fibulin-1

FBLN1

-1.56

1.59

1.27e-11

3.34e-11

negative regulation of protein phosphorylation,neg...

fibronectin binding,extracellular matrix structura...

extracellular region,proteinaceous extracellular m...

128

25

36

_EFTRPEEIIFLR_.3|_EFTRPEEIIFLR_.2|_TGYYFDGISR_.2|_...

SEN / CTL

P08962

CD63 antigen

CD63

-1.57

0.54

0.000311

0.000324

positive regulation of receptor internalization,pl...

protein binding

extracellular space,lysosomal membrane,plasma memb...

7

6

6

_VMSEFNNNFR_.2|_QQMENYPK_.2|_NNHTASILDR_.2|_AIHKEG...

SEN / CTL

Q15063

Periostin

POSTN

-1.6

1.14

2.41e-40

2.89e-39

skeletal system development,response to hypoxia,ne...

protein binding,heparin binding,metal ion binding,...

proteinaceous extracellular matrix,extracellular s...

176

48

80

_AAAITSDILEALGR_.2|_GFEPGVTNILK_.2|_QVIELAGK_.2|_I...

SEN / CTL

P07858

Cathepsin B

CTSB

-1.63

0.92

7.93e-51

1.7e-49

toll-like receptor signaling pathway,proteolysis,c...

cysteine-type endopeptidase activity,serine-type e...

extracellular region,extracellular space,intracell...

194

22

46

_GQDHC[+57]GIESEVVAGIPR_.3|_GQDHC[+57]GIESEVVAGIPR...

SEN / CTL

P24592

Insulin-like growth factor-binding protein 6

IGFBP6

-1.63

0.3

2.04e-27

1.57e-26

regulation of cell growth,signal transduction,nega...

receptor binding,insulin-like growth factor I bind...

extracellular region,extracellular space,Golgi app...

35

4

4

_HLDSVLQQLQTEVYR_.3|_EGQEC[+57]GVYTPNC[+57]APGLQC[...

SEN / CTL

Q9UBS4

DnaJ homolog subfamily B member 11

DNAJB11

-1.63

0.28

3.07e-8

6.14e-8

protein folding,positive regulation of ATPase acti...

protein binding,unfolded protein binding

endoplasmic reticulum,endoplasmic reticulum lumen,...

10

18

22

_TTQLGPGR_.2|_KGEGLPNFDNNNIK_.3|_KGEGLPNFDNNNIK_.2...

SEN / CTL

P46087

Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

NOP2

-1.63

0.63

0.000147

0.000161

maturation of LSU-rRNA,regulation of transcription...

RNA binding,protein binding,rRNA (cytosine-C5-)-me...

nucleoplasm,nucleolus

7

26

28

_LGVTNTIISHYDGR_.2|_LGVTNTIISHYDGR_.3|_GADSELSTVPS...

SEN / CTL

Q8N1N4

Keratin, type II cytoskeletal 78

KRT78

-1.66

0.82

0.0876

0.0466

keratinization,cornification

structural molecule activity

extracellular space,cytosol,keratin filament,extra...

3

13

14

_TLNNQFASFIDKVR_.3|_YLDFSSIITEVR_.2|_VQISQLHQEIQR_...

SEN / CTL

Q10471

Polypeptide N-acetylgalactosaminyltransferase 2

GALNT2

-1.67

0.75

1.47e-8

3.03e-8

immunoglobulin biosynthetic process,protein O-link...

polypeptide N-acetylgalactosaminyltransferase acti...

Golgi membrane,endoplasmic reticulum membrane,Golg...

25

28

40

_NVPYGNIQSR_.2|_SGQDPYAR_.2|_VWQC[+57]GGSLEIIPC[+5...

SEN / CTL

P15880

40S ribosomal protein S2

RPS2

-1.68

1.36

0.0000024

0.00000357

nuclear-transcribed mRNA catabolic process, nonsen...

RNA binding,mRNA binding,structural constituent of...

nucleus,nucleoplasm,cytosol,focal adhesion,membran...

37

20

34

_GTGIVSAPVPK_.2|_GC[+57]TATLGNFAK_.2|_TYSYLTPDLWK_...

SEN / CTL

P47897

Glutamine--tRNA ligase

QARS

-1.68

0.53

0.00453

0.00361

tRNA aminoacylation for protein translation,glutam...

glutamine-tRNA ligase activity,protein binding,ATP...

cytoplasm,mitochondrial matrix,cytosol,mitochondri...

5

59

101

_VGVTVAQTTMEPHLLEAC[+57]VR_.3|_VGVTVAQTTM[+16]EPHL...

SEN / CTL

P19021

Peptidyl-glycine alpha-amidating monooxygenase

PAM

-1.69

0.61

0.000052

0.0000624

peptide amidation,response to hypoxia,long-chain f...

peptidylglycine monooxygenase activity,peptidylami...

extracellular space,trans-Golgi network,plasma mem...

11

7

9

_QSPQLPQAFYPVGHPVDVSFGDLLAAR_.3|_QSPQLPQAFYPVGHPVD...

SEN / CTL

P12110

Collagen alpha-2(VI) chain

COL6A2

-1.72

1.26

6.82e-42

8.52e-41

cell adhesion,response to glucose,extracellular ma...

protein binding

extracellular region,proteinaceous extracellular m...

188

42

57

_NFVINVVNR_.2|_AAVFHEKDYDSLAQPGFFDR_.4|_AAVFHEKDYD...

SEN / CTL

P34741

Syndecan-2

SDC2

-1.72

0.41

0.000732

0.000708

retinoid metabolic process,glycosaminoglycan biosy...

protein binding,PDZ domain binding

Golgi lumen,plasma membrane,integral component of ...

5

1

1

_KMDPAEEDTNVYTEK_.3

SEN / CTL

O95084

Serine protease 23

PRSS23

-1.73

0.39

0.00000156

0.00000235

proteolysis

serine-type endopeptidase activity

extracellular space,nucleus,extracellular exosome

9

5

6

_LEVSSSC[+57]GPQC[+57]HK_.3|_LEVSSSC[+57]GPQC[+57]...

SEN / CTL

P55058

Phospholipid transfer protein

PLTP

-1.74

0.46

8.99e-13

2.75e-12

lipid metabolic process,lipid transport,vitamin E ...

lipid binding

extracellular region,extracellular space

20

6

7

_AVEPQLQEEER_.2|_FLEQELETITIPDLR_.2|_FLEQELETITIPD...

SEN / CTL

Q9NV70

Exocyst complex component 1

EXOC1

-1.74

0.17

0.00362

0.00299

exocytosis,Golgi to plasma membrane transport,prot...

protein binding,phosphatidylinositol-4,5-bisphosph...

exocyst,cytoplasm,cytosol,plasma membrane,membrane...

3

26

36

_LLDEALK_.2|_ELQVLDGANIQSIMASEK_.2|_LNHFFEGVEAR_.3...

SEN / CTL

Q96CG8

Collagen triple helix repeat-containing protein 1

CTHRC1

-1.76

0.55

2.39e-15

9.94e-15

cell migration,positive regulation of protein bind...

frizzled binding,Wnt-protein binding

proteinaceous extracellular matrix,collagen trimer...

30

3

3

_IIIEELPK_.2|_QC[+57]SWSSLNYGIDLGK_.2|_GDASTGWNSVS...

SEN / CTL

P05141 P12236

ADP/ATP translocase 2;ADP/ATP translocase 3

SLC25A5 SLC25A6

-1.76

0.81

0.0525

0.0297

transport,chromosome segregation,positive regulati...

RNA binding,ATP:ADP antiporter activity,protein bi...

nucleus,mitochondrion,mitochondrial inner membrane...

4

5

7

_TAVAPIER_.2|_GLGDC[+57]LVK_.2|_QIFLGGVDK_.2|_GAWS...

SEN / CTL

Q9UBG0

C-type mannose receptor 2

MRC2

-1.77

1.92

0.0221

0.0142

osteoblast differentiation,endocytosis,signal tran...

transmembrane signaling receptor activity,protein ...

integral component of plasma membrane,focal adhesi...

26

30

39

_TLGDQLSLLLGAR_.2|_AGQLSQGAAEEDHGC[+57]R_.3|_C[+57...

SEN / CTL

O60568

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

PLOD3

-1.81

0.79

8.91e-43

1.16e-41

in utero embryonic development,endothelial cell mo...

iron ion binding,protein binding,procollagen-lysin...

endoplasmic reticulum membrane,rough endoplasmic r...

112

41

68

_LVGPEEALSPGEAR_.2|_YDC[+57]VISSPR_.2|_SEDYVELVQR_...

SEN / CTL

P33908

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

MAN1A1

-1.82

0.28

0.000128

0.000143

protein glycosylation,N-glycan processing,Golgi ap...

mannosyl-oligosaccharide 1,2-alpha-mannosidase act...

Golgi membrane,endoplasmic reticulum,endoplasmic r...

5

12

15

_FDGGVEAIATR_.2|_GYAWGLNELKPISK_.3|_GYAWGLNELKPISK...

SEN / CTL

P98160

Basement membrane-specific heparan sulfate proteoglycan core protein

HSPG2

-1.85

1.57

8.86e-9

1.93e-8

retinoid metabolic process,angiogenesis,glycosamin...

calcium ion binding,protein binding,protein C-term...

extracellular region,basement membrane,extracellul...

139

163

239

_FSSGITGC[+57]VK_.2|_LVSEDPINDGEWHR_.3|_AVTLEC[+57...

SEN / CTL

P62873

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

GNB1

-1.86

1.16

1.36e-7

2.45e-7

protein folding,signal transduction,adenylate cycl...

GTPase activity,signal transducer activity,protein...

photoreceptor inner segment,intracellular,lysosoma...

24

10

16

_LFVSGAC[+57]DASAK_.2|_LLLAGYDDFNC[+57]NVWDALKADR_...

SEN / CTL

P35052

Glypican-1

GPC1

-1.9

1.02

5.6e-23

3.73e-22

retinoid metabolic process,glycosaminoglycan biosy...

copper ion binding,fibroblast growth factor bindin...

proteinaceous extracellular matrix,extracellular s...

67

13

13

_GFSLSDVPQAEISGEHLR_.3|_SFVQGLGVASDVVR_.2|_VLQAMLA...

SEN / CTL

P24593

Insulin-like growth factor-binding protein 5

IGFBP5

-1.91

1.88

0.000588

0.000576

regulation of cell growth,osteoblast differentiati...

fibronectin binding,protein binding,insulin-like g...

extracellular region,intracellular,insulin-like gr...

22

3

3

_FVGGAENTAHPR_.3|_HMEASLQELK_.2|_ALSMC[+57]PPSPLGC...

SEN / CTL

P61769

Beta-2-microglobulin

B2M

-1.93

2.01

0.0000139

0.0000184

retina homeostasis,positive regulation of T cell m...

glycoprotein binding,protein binding,identical pro...

Golgi membrane,extracellular region,extracellular ...

28

7

9

_VNHVTLSQPK_.2|_IEKVEHSDLSFSK_.3|_SNFLNC[+57]YVSGF...

SEN / CTL

Q8IUX7

Adipocyte enhancer-binding protein 1

AEBP1

-1.95

0.31

3.72e-7

6.3e-7

negative regulation of transcription from RNA poly...

RNA polymerase II regulatory region sequence-speci...

extracellular space,nucleus,cytoplasm,extracellula...

9

9

11

_VVNEEC[+57]PTITR_.2|_FTGVITQGR_.2|_YLSPDATVSTEVR_...

SEN / CTL

P61586

Transforming protein RhoA

RHOA

-1.98

0.55

7.92e-11

1.98e-10

transforming growth factor beta receptor signaling...

GTPase activity,protein binding,GTP binding,myosin...

endosome,endoplasmic reticulum membrane,cytosol,cy...

19

17

30

_EVFEMATR_.2|_LVIVGDGAC[+57]GK_.2|_TC[+57]LLIVFSK_...

SEN / CTL

P20339 P51148 P61020

Ras-related protein Rab-5A;Ras-related protein Rab-5C;Ras-related protein Rab-5B

RAB5A RAB5C RAB5B

-1.98

0.65

0.0000266

0.0000337

phosphatidylinositol biosynthetic process,endocyto...

GTPase activity,protein binding,GTP binding,GDP bi...

ruffle,cytoplasm,endosome,early endosome,cytosol,p...

9

2

4

_LVLLGESAVGK_.2|_YHSLAPMYYR_.3|_YHSLAPM[+16]YYR_.3...

SEN / CTL

Q92859

Neogenin

NEO1

-1.98

0.2

0.000428

0.00043

cell adhesion,axon guidance,positive regulation of...

receptor activity,protein binding,co-receptor bind...

nucleoplasm,Golgi apparatus,plasma membrane,integr...

4

6

6

_QLLPDGSLFISNVVHSK_.3|_NEEALDTESSER_.2|_SHLYHPGSPW...

SEN / CTL

Q9GZX9

Twisted gastrulation protein homolog 1

TWSG1

-2.03

0.91

5e-19

2.68e-18

ossification,mesoderm formation,salivary gland mor...

protein binding

extracellular space,extracellular exosome

49

4

6

_ALC[+57]ASDVSK_.2|_STVEELHEPIPSLFR_.3|_STVEELHEPI...

SEN / CTL

Q9Y240

C-type lectin domain family 11 member A

CLEC11A

-2.03

1.67

6.93e-12

1.87e-11

positive regulation of cell proliferation

growth factor activity,carbohydrate binding

extracellular region,extracellular space,cytoplasm

74

12

16

_VVELTQGLR_.2|_GGSLAQPADR_.2|_DFEAQAAAQAR_.2|_LAGL...

SEN / CTL

Q14767

Latent-transforming growth factor beta-binding protein 2

LTBP2

-2.05

1.56

5.33e-13

1.7e-12

protein targeting,transforming growth factor beta ...

calcium ion binding,protein binding,heparin bindin...

proteinaceous extracellular matrix,extracellular s...

65

8

8

_EQDAPVAGLQPVER_.2|_STPLGQQQPAPR_.2|_ALLEAPLKQSTFT...

SEN / CTL

P18465

HLA class I histocompatibility antigen, B-57 alpha chain

HLA-B

-2.05

0.33

0.00889

0.00646

3

1

1

_AYLEGLC[+57]VEWLR_.2

SEN / CTL

Q9BRK5

45 kDa calcium-binding protein

SDF4

-2.06

0.59

2.91e-28

2.29e-27

UV protection,calcium ion regulated exocytosis,cer...

calcium ion binding,identical protein binding

cytoplasm,late endosome,Golgi apparatus,Golgi lume...

53

20

30

_YSEFFTGSK_.2|_LNEELKVDEETQEVLENLKDR_.4|_LNEELKVDE...

SEN / CTL

Q6ZSZ5

Rho guanine nucleotide exchange factor 18

ARHGEF18

-2.07

0.52

4.76e-7

7.94e-7

transforming growth factor beta receptor signaling...

guanyl-nucleotide exchange factor activity,Rho gua...

cytosol,cytoskeleton,plasma membrane,apical plasma...

10

19

24

_LLLQQNK_.2|_YGVFC[+57]SGHNEAVSHYK_.4|_YGVFC[+57]S...

SEN / CTL

P48723

Heat shock 70 kDa protein 13

HSPA13

-2.11

0.31

1.02e-11

2.7e-11

protein binding,ATP binding

endoplasmic reticulum,intracellular membrane-bound...

14

11

13

_ILVPIQQVLK_.2|_LGGQDFNQR_.2|_VINEPTAAAMAYGLHK_.3|...

SEN / CTL

Q02809

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

PLOD1

-2.12

1.23

2.92e-56

7.98e-55

response to hypoxia,cellular protein modification ...

iron ion binding,procollagen-lysine 5-dioxygenase ...

endoplasmic reticulum membrane,rough endoplasmic r...

224

37

56

_NVIAPLMTR_.2|_LYPGYYTR_.2|_VGVDYEGGGC[+57]R_.2|_S...

SEN / CTL

P26022

Pentraxin-related protein PTX3

PTX3

-2.12

1.11

7.8e-21

4.59e-20

response to yeast,inflammatory response,opsonizati...

complement component C1q binding,(1->3)-beta-D-glu...

extracellular region,extracellular space,specific ...

60

7

7

_ALAAVLEELR_.2|_LTSALDELLQATR_.2|_ADLHAVQGWAAR_.3|...

SEN / CTL

P60953

Cell division control protein 42 homolog

CDC42

-2.14

0.41

7.78e-8

1.46e-7

sprouting angiogenesis,cardiac conduction system d...

GTPase activity,protein binding,GTP binding,protei...

Golgi membrane,storage vacuole,cytoplasm,endoplasm...

10

20

29

_YVEC[+57]SALTQK_.2|_QKPITPETAEK_.3|_QKPITPETAEK_....

SEN / CTL

Q86UD1

Out at first protein homolog

OAF

-2.22

0.14

0.0000882

0.000101

extracellular exosome

4

2

2

_ALILGELEK_.2|_GQSQFQALC[+57]FVTQLQHNEIIPSEAMAK_.3

SEN / CTL

Q99715

Collagen alpha-1(XII) chain

COL12A1

-2.26

1.25

3.94e-119

2.95e-117

skeletal system development,cell adhesion,collagen...

extracellular matrix structural constituent confer...

extracellular region,collagen type XII trimer,extr...

448

96

114

_ALALGALQNIR_.2|_VLVVVTDGR_.2|_IIYRPVAGGESR_.3|_VT...

SEN / CTL

Q14766

Latent-transforming growth factor beta-binding protein 1

LTBP1

-2.27

1.07

6.79e-56

1.7e-54

ventricular septum development,transmembrane recep...

transforming growth factor beta-activated receptor...

microfibril,extracellular region,proteinaceous ext...

144

35

44

_EAQPGQSQVSYQGLPVQK_.2|_VQEGYTC[+57]DC[+57]FDGYHLD...

SEN / CTL

Q8NBJ4

Golgi membrane protein 1

GOLM1

-2.27

0.91

0.0000382

0.0000471

nucleus organization,regulation of lipid metabolic...

protein binding

extracellular space,Golgi apparatus,integral compo...

16

21

27

_QQLQALSEPQPR_.2|_DTINLLDQR_.2|_NIDVFNVEDQKR_.3|_N...

SEN / CTL

P16070

CD44 antigen

CD44

-2.29

0.98

1.39e-21

8.66e-21

cell-matrix adhesion,single organismal cell-cell a...

protein binding,collagen binding,hyaluronic acid b...

Golgi apparatus,cytosol,plasma membrane,integral c...

62

12

18

_ALSIGFETC[+57]R_.2|_YGFIEGHVVIPR_.3|_YGFIEGHVVIPR...

SEN / CTL

P12111

Collagen alpha-3(VI) chain

COL6A3

-2.33

1.37

0

0

cell adhesion,muscle organ development,negative re...

serine-type endopeptidase inhibitor activity

extracellular region,proteinaceous extracellular m...

1292

165

233

_IIDELNVKPEGTR_.3|_IIDELNVKPEGTR_.2|_ALILVGLER_.2|...

SEN / CTL

Q16610

Extracellular matrix protein 1

ECM1

-2.33

1.25

1.43e-43

1.94e-42

ossification,angiogenesis,positive regulation of e...

protease binding,signal transducer activity,interl...

extracellular region,proteinaceous extracellular m...

160

22

28

_ELLALIQLER_.2|_LVWEEAMSR_.2|_FC[+57]EAEFSVK_.2|_L...

SEN / CTL

O00391

Sulfhydryl oxidase 1

QSOX1

-2.34

1.05

2.45e-81

9.18e-80

platelet degranulation,negative regulation of macr...

protein disulfide isomerase activity,flavin-linked...

extracellular region,extracellular space,Golgi app...

225

23

29

_DFNIPGFPTVR_.2|_LAGAPSEDPQFPK_.2|_SFYTAYLQR_.2|_V...

SEN / CTL

Q12797

Aspartyl/asparaginyl beta-hydroxylase

ASPH

-2.35

0.76

0.00000427

0.00000619

muscle contraction,pattern specification process,n...

peptide-aspartate beta-dioxygenase activity,struct...

endoplasmic reticulum,endoplasmic reticulum membra...

13

34

40

_ETGYTELVK_.2|_GLFLPEDENLREK_.3|_GSLLTLQR_.2|_KVYE...

SEN / CTL

P02751

Fibronectin

FN1

-2.39

1.3

0

0

angiogenesis,regulation of protein phosphorylation...

protease binding,integrin binding,protein binding,...

extracellular region,fibrinogen complex,proteinace...

1291

126

209

_STTPDITGYR_.2|_WSRPQAPITGYR_.3|_ISC[+57]TIANR_.2|...

SEN / CTL

P17900

Ganglioside GM2 activator

GM2A

-2.4

2.52

0.0625

0.0346

glycosphingolipid metabolic process,ganglioside ca...

lipid transporter activity,phospholipase activator...

extracellular region,mitochondrion,hydrogen:potass...

21

10

12

_EGTYSLPK_.2|_SEFVVPDLELPSWLTTGNYR_.2|_SEFVVPDLELP...

SEN / CTL

O14672

Disintegrin and metalloproteinase domain-containing protein 10

ADAM10

-2.43

0.34

3.19e-18

1.57e-17

in utero embryonic development,protein phosphoryla...

endopeptidase activity,metalloendopeptidase activi...

Golgi membrane,extracellular space,nucleus,cytopla...

22

21

28

_GGTFYVEPAER_.2|_YGPQGGC[+57]ADHSVFER_.3|_AIDTIYQT...

SEN / CTL

Q05707

Collagen alpha-1(XIV) chain

COL14A1

-2.45

0.82

0.0388

0.0231

single organismal cell-cell adhesion,extracellular...

RNA binding,extracellular matrix structural consti...

extracellular region,proteinaceous extracellular m...

3

66

92

_IGILITDGK_.2|_DEVIEAVR_.2|_HVFFVDDFDAFKK_.4|_HVFF...

SEN / CTL

Q6EMK4

Vasorin

VASN

-2.48

0.49

8.93e-46

1.41e-44

negative regulation of epithelial to mesenchymal t...

protein binding,cadherin binding,transforming grow...

extracellular space,mitochondrion,lysosomal membra...

62

8

8

_SLTLGIEPVSPTSLR_.2|_YLQGSSVQLR_.2|_ESHVTLASPEETR_...

SEN / CTL

O00560

Syntenin-1

SDCBP

-2.5

0.68

0.0000318

0.0000398

negative regulation of receptor internalization,pr...

frizzled binding,interleukin-5 receptor binding,pr...

extracellular region,extracellular space,nucleus,n...

9

13

25

_SLMDHTIPEV_.2|_ANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDV...

SEN / CTL

Q9UKU6

Thyrotropin-releasing hormone-degrading ectoenzyme

TRHDE

-2.51

0.02

0.00362

0.00299

proteolysis,signal transduction,cell-cell signalin...

aminopeptidase activity,zinc ion binding,peptide b...

cytoplasm,integral component of plasma membrane,ex...

2

2

2

_AVETVEANVR_.2|_IIITQQHFIYDISAK_.3

SEN / CTL

O95433

Activator of 90 kDa heat shock protein ATPase homolog 1

AHSA1

-2.53

1.02

0.0676

0.0373

response to stress,positive regulation of ATPase a...

ATPase activator activity,protein binding,cadherin...

endoplasmic reticulum,cytosol,extracellular exosom...

4

31

43

_C[+57]EVTEVSKLDGEASINNR_.3|_YYFEGIK_.2|_GIPAPEEER...

SEN / CTL

Q9HCU0

Endosialin

CD248

-2.54

0.23

6.49e-10

1.54e-9

biological_process,positive regulation of cell pro...

molecular_function,calcium ion binding,carbohydrat...

proteinaceous extracellular matrix,cytoplasm,integ...

9

1

1

_VDSLVGAGPASR_.2

SEN / CTL

Q92542

Nicastrin

NCSTN

-2.55

0.92

0.000389

0.000396

myeloid cell homeostasis,proteolysis,membrane prot...

endopeptidase activity,protein binding

lysosomal membrane,endoplasmic reticulum,Golgi app...

8

10

12

_SGAGVPAVILR_.2|_ALADVATVLGR_.2|_NQVEDLLATLEK_.2|_...

SEN / CTL

O00186

Syntaxin-binding protein 3

STXBP3

-2.57

0.19

0.00012

0.000135

vesicle docking involved in exocytosis,brain devel...

protein binding,syntaxin-1 binding,syntaxin bindin...

cytosol,plasma membrane,basolateral plasma membran...

4

24

32

_LAQLVEK_.2|_ALYFITPTSK_.2|_SVDC[+57]FLHDFASK_.3|_...

SEN / CTL

P14209

CD99 antigen

CD99

-2.59

1.74

0.0118

0.00823

cell adhesion

cytoplasm,plasma membrane,integral component of pl...

6

4

6

_NANAEPAVQR_.2|_ENAEQGEVDMESHR_.3|_ENAEQGEVDM[+16]...

SEN / CTL

P55290

Cadherin-13

CDH13

-2.62

1.29

0.0155

0.0104

mitotic cell cycle,positive regulation of endothel...

calcium ion binding,low-density lipoprotein partic...

extracellular space,cytoplasm,plasma membrane,cave...

7

7

9

_INENTGSVSVTR_.2|_SIVVSPILIPENQR_.2|_DIQGSLQDIFK_....

SEN / CTL

P13611

Versican core protein

VCAN

-2.66

1.34

5.05e-39

5.82e-38

skeletal system development,osteoblast differentia...

extracellular matrix structural constituent,calciu...

extracellular region,proteinaceous extracellular m...

106

17

23

_AQC[+57]GGGLLGVR_.2|_LLASDAGLYR_.2|_YEINSLIR_.2|_...

SEN / CTL

P63000

Ras-related C3 botulinum toxin substrate 1

RAC1

-2.66

0.42

3.36e-30

2.88e-29

positive regulation of protein phosphorylation,aud...

GTPase activity,protein binding,GTP binding,Rab GT...

Golgi membrane,pericentriolar material,phagocytic ...

40

12

21

_YLEC[+57]SALTQR_.2|_C[+57]VVVGDGAVGK_.2|_TVFDEAIR...

SEN / CTL

P15291

Beta-1,4-galactosyltransferase 1

B4GALT1

-2.67

2.53

0.0788

0.0426

epithelial cell development,acute inflammatory res...

beta-N-acetylglucosaminylglycopeptide beta-1,4-gal...

Golgi trans cisterna,Golgi membrane,extracellular ...

4

7

9

_VAIIIPFR_.2|_QQLDYGIYVINQAGDTIFNR_.3|_ETMLSDGLNSL...

SEN / CTL

Q15262

Receptor-type tyrosine-protein phosphatase kappa

PTPRK

-2.69

1.7

9.78e-7

0.00000154

protein dephosphorylation,cell adhesion,signal tra...

protein tyrosine phosphatase activity,transmembran...

photoreceptor outer segment,plasma membrane,integr...

22

12

13

_VLLTRPGEGGTGLPGPPLITR_.3|_GLNPGTLNILVR_.2|_GSGVSN...

SEN / CTL

Q14118

Dystroglycan

DAG1

-2.73

0.81

6.59e-13

2.04e-12

positive regulation of cell-matrix adhesion,morpho...

virus receptor activity,actin binding,calcium ion ...

extracellular region,basement membrane,extracellul...

23

17

21

_VTIPTDLIASSGDIIK_.2|_LGC[+57]SLNQNSVPDIHGVEAPAR_....

SEN / CTL

P50995

Annexin A11

ANXA11

-2.73

0.24

0.00000823

0.0000114

phagocytosis,cell cycle,cell division,response to ...

RNA binding,calcium ion binding,protein binding,ca...

nuclear envelope,nucleoplasm,cytoplasm,spindle,cyt...

5

29

45

_FNAVLC[+57]SR_.2|_GVGTDEAC[+57]LIEILASR_.2|_GVGTD...

SEN / CTL

P01137

Transforming growth factor beta-1

TGFB1

-2.74

1.25

3.83e-14

1.34e-13

protein import into nucleus, translocation,negativ...

glycoprotein binding,antigen binding,type II trans...

extracellular region,proteinaceous extracellular m...

44

16

20

_GGEIEGFR_.2|_VEQLSNMIVR_.2|_EAVPEPVLLSR_.2|_VLALY...

SEN / CTL

Q13438

Protein OS-9

OS9

-2.76

0.93

0.00357

0.00297

protein targeting,protein retention in ER lumen,pr...

glycoprotein binding,protease binding,protein bind...

Hrd1p ubiquitin ligase complex,endoplasmic reticul...

6

17

20

_AMLALTSTLNK_.2|_AM[+16]LALTSTLNK_.2|_IVRPWAEGTEEG...

SEN / CTL

P07711

Cathepsin L1

CTSL

-2.79

1.11

2.03e-17

9.39e-17

toll-like receptor signaling pathway,adaptive immu...

fibronectin binding,cysteine-type endopeptidase ac...

extracellular region,extracellular space,nucleus,l...

42

9

13

_NHC[+57]GIASAASYPTV_.2|_VFQEPLFYEAPR_.2|_VFQEPLFY...

SEN / CTL

P07093

Glia-derived nexin

SERPINE2

-2.79

0.77

6.52e-8

1.24e-7

blood coagulation,negative regulation of cell prol...

serine-type endopeptidase inhibitor activity,recep...

extracellular region,extracellular space,cytosol,e...

15

11

14

_ASAATTAILIAR_.2|_LVLVNAVYFK_.2|_SYQVPMLAQLSVFR_.2...

SEN / CTL

P35442

Thrombospondin-2

THBS2

-2.8

0.86

6.3e-18

3e-17

cell adhesion,negative regulation of angiogenesis,...

calcium ion binding,protein binding,heparin bindin...

extracellular region,basement membrane,extracellul...

34

10

12

_NALWHTGNTPGQVR_.3|_NALWHTGNTPGQVR_.2|_FYVVMWK_.2|...

SEN / CTL

Q9UBI6

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

GNG12

-2.82

1.02

0.0000693

0.0000822

signal transduction,G-protein coupled receptor sig...

signal transducer activity,protein binding,PDZ dom...

heterotrimeric G-protein complex,actin filament,pl...

12

6

10

_TASTNNIAQAR_.2|_LEASIER_.2|_ASADLMSYC[+57]EEHAR_....

SEN / CTL

P13987

CD59 glycoprotein

CD59

-2.83

0.6

4.96e-29

4.02e-28

cell activation,negative regulation of activation ...

complement binding,protein binding

Golgi membrane,extracellular space,endoplasmic ret...

42

6

9

_AGLQVYNK_.2|_LRENELTYYC[+57]C[+57]KK_.3|_FEHC[+57...

SEN / CTL

O00622

Protein CYR61

CYR61

-2.84

1.54

0.000412

0.000417

regulation of cell growth,osteoblast differentiati...

integrin binding,insulin-like growth factor bindin...

extracellular space,extracellular matrix,proteinac...

15

17

20

_C[+57]APGVGLVR_.2|_AQSEGRPC[+57]EYNSR_.3|_GLEC[+5...

SEN / CTL

P00749

Urokinase-type plasminogen activator

PLAU

-2.85

1.02

3.4e-7

5.8e-7

response to hypoxia,proteolysis,chemotaxis,signal ...

serine-type endopeptidase activity,protein binding

extracellular region,extracellular space,plasma me...

15

6

7

_VSHFLPWIR_.2|_IIGGEFTTIENQPWFAAIYR_.3|_DYSADTLAHH...

SEN / CTL

P08603

Complement factor H

CFH

-2.86

1.34

0.00983

0.00702

complement activation,complement activation, alter...

protein binding,heparin binding,heparan sulfate pr...

extracellular region,extracellular space,extracell...

11

66

115

_TGDEITYQC[+57]R_.2|_LSYTC[+57]EGGFR_.2|_SIDVAC[+5...

SEN / CTL

Q13308

Inactive tyrosine-protein kinase 7

PTK7

-2.87

1.51

0.000167

0.000181

establishment of planar polarity,ventricular septu...

protein kinase activity,protein binding,ATP bindin...

integral component of plasma membrane,cell-cell ju...

14

30

35

_VVLAPQDVVVAR_.2|_ADGSSLPEWVTDNAGTLHFAR_.3|_VFTAGS...

SEN / CTL

Q13740

CD166 antigen

ALCAM

-2.92

1.31

2.06e-18

1.03e-17

adaptive immune response,cell adhesion,heterophili...

receptor binding,protein binding

immunological synapse,integral component of plasma...

58

30

45

_ESLTLIVEGKPQIK_.2|_ESLTLIVEGKPQIK_.3|_SSNTYTLTDVR...

SEN / CTL

O00468

Agrin

AGRN

-2.95

1.33

6.96e-90

3.48e-88

retinoid metabolic process,glycosaminoglycan biosy...

dystroglycan binding,structural constituent of cyt...

extracellular region,basal lamina,Golgi lumen,cyto...

233

54

64

_VLGAPVPAFEGR_.2|_LELGIGPGAATR_.2|_LLDVNNQR_.2|_SF...

SEN / CTL

Q03113 Q14344

Guanine nucleotide-binding protein subunit alpha-12;Guanine nucleotide-binding protein subunit alpha-13

GNA12 GNA13

-2.99

0.57

2.67e-7

4.64e-7

in utero embryonic development,G-protein coupled r...

GTPase activity,signal transducer activity,protein...

heterotrimeric G-protein complex,plasma membrane,f...

9

2

2

_ILLLGAGESGK_.2|_MVDVGGQR_.2

SEN / CTL

Q9NZN5

Rho guanine nucleotide exchange factor 12

ARHGEF12

-3

0.87

0.0000486

0.000059

G-protein coupled receptor signaling pathway,regul...

G-protein coupled receptor binding,guanyl-nucleoti...

cytoplasm,cytosol,membrane,extracellular exosome

8

23

24

_SMGLTLAESELTK_.2|_MIHEGPLVWK_.3|_VNGTLVTHSNHLEVVK...

SEN / CTL

P19022

Cadherin-2

CDH2

-3.03

0.46

0.00000516

0.00000741

cell adhesion,homophilic cell adhesion via plasma ...

calcium ion binding,protein binding,beta-catenin b...

cytoplasm,plasma membrane,cell-cell junction,cell-...

8

17

22

_FAIQTDPNSNDGLVTVVKPIDFETNR_.3|_FAIQTDPNSNDGLVTVVK...

SEN / CTL

P62879

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

GNB2

-3.05

1.05

2.17e-14

7.74e-14

protein folding,G-protein coupled receptor signali...

GTPase activity,signal transducer activity,calcium...

extracellular space,lysosomal membrane,cytosol,pla...

33

18

31

_LLVSASQDGK_.2|_AGVLAGHDNR_.2|_ELPGHTGYLSC[+57]C[+...

SEN / CTL

P62834

Ras-related protein Rap-1A

RAP1A

-3.07

2.72

0.0776

0.0421

activation of MAPKK activity,signal transduction,p...

GTPase activity,protein binding,GTP binding,protei...

cytoplasm,early endosome,late endosome,cytosol,pla...

8

9

14

_LVVLGSGGVGK_.2|_SKINVNEIFYDLVR_.3|_SKINVNEIFYDLVR...

SEN / CTL

P07996

Thrombospondin-1

THBS1

-3.09

0.71

1.52e-142

1.52e-140

activation of MAPK activity,response to hypoxia,ne...

phosphatidylserine binding,glycoprotein binding,fi...

extracellular region,fibrinogen complex,extracellu...

233

61

86

_FVFGTTPEDILR_.2|_TIVTTLQDSIR_.2|_AQGYSGLSVK_.2|_F...

SEN / CTL

Q13443

Disintegrin and metalloproteinase domain-containing protein 9

ADAM9

-3.09

0.4

3.97e-12

1.14e-11

activation of MAPKK activity,membrane protein ecto...

metalloendopeptidase activity,protein kinase C bin...

extracellular space,focal adhesion,cell surface,in...

14

22

24

_QVSYVIQAEGK_.2|_EGTLITDHPNIQNHC[+57]HYR_.5|_EGTLI...

SEN / CTL

P05067

Amyloid beta A4 protein

APP

-3.11

0.51

2.97e-47

4.95e-46

positive regulation of protein phosphorylation,suc...

DNA binding,serine-type endopeptidase inhibitor ac...

extracellular region,extracellular space,nuclear e...

60

21

26

_WYFDVTEGK_.2|_THPHFVIPYR_.3|_QQLVETHMAR_.3|_C[+57...

SEN / CTL

P02786

Transferrin receptor protein 1

TFRC

-3.11

0.52

0.0000486

0.000059

cellular iron ion homeostasis,osteoclast different...

virus receptor activity,glycoprotein binding,RNA b...

extracellular region,extracellular space,endosome,...

7

42

60

_LLNENSYVPR_.2|_SSGLPNIPVQTISR_.2|_GFVEPDHYVVVGAQR...

SEN / CTL

Q29865

HLA class I histocompatibility antigen, Cw-18 alpha chain

HLA-C

-3.14

0.75

3.75e-18

1.81e-17

31

8

11

_WAAVVVPSGEEQR_.2|_FDSDAASPR_.2|_SWTAADTAAQITQR_.2...

SEN / CTL

P01892

HLA class I histocompatibility antigen, A-2 alpha chain

HLA-A

-3.16

1.81

2e-14

7.41e-14

60

21

35

_WAAVVVPSGQEQR_.2|_AYLEGTC[+57]VEWLR_.2|_FDSDAASQR...

SEN / CTL

P11233

Ras-related protein Ral-A

RALA

-3.23

0.01

0.00142

0.00129

cytokinesis,neural tube closure,exocytosis,chemota...

GTPase activity,protein binding,GTP binding,myosin...

plasma membrane,focal adhesion,cell surface,midbod...

2

7

11

_VIMVGSGGVGK_.2|_VIM[+16]VGSGGVGK_.2|_NRAEQWNVNYVE...

SEN / CTL

O43491

Band 4.1-like protein 2

EPB41L2

-3.24

0.13

0.0314

0.0192

cortical actin cytoskeleton organization,actomyosi...

actin binding,structural constituent of cytoskelet...

nucleus,nucleoplasm,cytosol,plasma membrane,focal ...

3

68

99

_EVPIVQTETK_.2|_SYTLVVAK_.2|_HQASISELK_.2|_EQHPDMS...

SEN / CTL

P04156

Major prion protein

PRNP

-3.26

1.22

0.00000984

0.0000133

negative regulation of protein phosphorylation,cel...

beta-amyloid binding,signal transducer activity,re...

cytoplasm,endoplasmic reticulum,Golgi apparatus,cy...

10

4

5

_VVEQMC[+57]ITQYER_.2|_VVEQM[+16]C[+57]ITQYER_.2|_...

SEN / CTL

P04899

Guanine nucleotide-binding protein G(i) subunit alpha-2

GNAI2

-3.32

0.89

2.46e-8

5.06e-8

activation of MAPKK activity,adenosine receptor si...

G-protein coupled receptor binding,GTPase activity...

nucleoplasm,cytoplasm,centrosome,cytosol,heterotri...

16

27

44

_MFDVGGQR_.2|_M[+16]FDVGGQR_.2|_IAQSDYIPTQQDVLR_.2...

SEN / CTL

P30479

HLA class I histocompatibility antigen, B-41 alpha chain

HLA-B

-3.48

0.87

4.08e-9

9.21e-9

14

6

8

_MYGC[+57]DVGPDGR_.2|_FDSDATSPR_.2|_APWIEQEGPEYWDR...

SEN / CTL

P01034

Cystatin-C

CST3

-3.54

0.68

3.18e-34

2.98e-33

eye development,response to hypoxia,apoptotic proc...

beta-amyloid binding,protease binding,endopeptidas...

extracellular region,basement membrane,extracellul...

53

7

11

_ALDFAVGEYNK_.2|_TQPNLDNC[+57]PFHDQPHLK_.4|_TQPNLD...

SEN / CTL

P01130

Low-density lipoprotein receptor

LDLR

-3.55

1.7

3.08e-17

1.4e-16

lipid metabolic process,endocytosis,receptor-media...

virus receptor activity,glycoprotein binding,prote...

lysosome,early endosome,late endosome,Golgi appara...

56

18

20

_NVVALDTEVASNR_.2|_AVGSIAYLFFTNR_.2|_SGDFSC[+57]GG...

SEN / CTL

P48509

CD151 antigen

CD151

-3.55

0.47

0.00782

0.00579

cell adhesion,cell surface receptor signaling path...

integrin binding,protein binding

basement membrane,cytosol,plasma membrane,integral...

3

4

4

_VVPDSC[+57]C[+57]K_.2|_TVVALC[+57]GQR_.2|_LETFIQE...

SEN / CTL

P05121

Plasminogen activator inhibitor 1

SERPINE1

-3.56

1.43

1.34e-29

1.11e-28

chronological cell aging,angiogenesis,platelet deg...

protease binding,serine-type endopeptidase inhibit...

extracellular region,extracellular space,plasma me...

68

9

10

_QFQADFTSLSDQEPLHVAQALQK_.3|_MAPEEIIMDRPFLFVVR_.3|...

SEN / CTL

Q15904

V-type proton ATPase subunit S1

ATP6AP1

-3.65

1.46

0.0000686

0.0000817

insulin receptor signaling pathway,ATP hydrolysis ...

transporter activity,ATP binding,Rab GTPase bindin...

endoplasmic reticulum membrane,endosome membrane,i...

13

9

11

_LPYTASSGLMAPR_.2|_LGASPLHVDLATLR_.3|_LGASPLHVDLAT...

SEN / CTL

P35613

Basigin

BSG

-3.78

0.37

5.19e-23

3.54e-22

pyruvate metabolic process,cell surface receptor s...

protein binding,mannose binding,monocarboxylic aci...

Golgi membrane,acrosomal membrane,mitochondrion,pl...

26

11

22

_FFVSSSQGR_.2|_GGVVLKEDALPGQK_.3|_GGVVLKEDALPGQK_....

SEN / CTL

P15151

Poliovirus receptor

PVR

-3.84

0.58

1.02e-12

3.05e-12

positive regulation of natural killer cell mediate...

virus receptor activity,receptor activity,receptor...

extracellular space,cytoplasm,plasma membrane,inte...

15

5

6

_VLAKPQNTAEVQK_.3|_VQLTGEPVPMAR_.2|_RLEFVAAR_.2|_H...

SEN / CTL

O75787

Renin receptor

ATP6AP2

-3.86

0.76

7.77e-15

3.03e-14

angiotensin maturation,rostrocaudal neural tube pa...

receptor activity,protein binding,enzyme binding

plasma membrane,external side of plasma membrane,i...

21

11

14

_ILVDALQK_.2|_ANSVFEDLSVTLR_.2|_LFQENSVLSSLPLNSLSR...

SEN / CTL

P25391

Laminin subunit alpha-1

LAMA1

-3.87

0.47

0.0133

0.00923

cell adhesion,cell surface receptor signaling path...

receptor binding,extracellular matrix structural c...

extracellular region,proteinaceous extracellular m...

4

71

84

_TPVTLGSDQPLLR_.2|_TPVTLGSDQPLLR_.3|_ASYGQGLQQSR_....

SEN / CTL

P05556

Integrin beta-1

ITGB1

-3.93

1.1

3.96e-45

5.95e-44

G1/S transition of mitotic cell cycle,in utero emb...

virus receptor activity,fibronectin binding,protea...

ruffle,cytoplasm,plasma membrane,focal adhesion,in...

81

36

53

_IGFGSFVEK_.2|_SAVTTVVNPK_.2|_SGEPQTFTLK_.2|_GIC[+...

SEN / CTL

O14786

Neuropilin-1

NRP1

-3.94

1.99

9.75e-9

2.09e-8

angiogenesis,patterning of blood vessels,neuron mi...

vascular endothelial growth factor-activated recep...

semaphorin receptor complex,extracellular space,ea...

29

12

14

_FVTAVGTQGAISK_.2|_EGNKPVLFQGNTNPTDVVVAVFPKPLITR_....

SEN / CTL

Q6UVK1

Chondroitin sulfate proteoglycan 4

CSPG4

-3.99

0.9

6.12e-102

3.67e-100

activation of MAPK activity,angiogenesis,transmemb...

signal transducer activity,protein kinase binding

extracellular region,Golgi lumen,integral componen...

158

46

56

_LVLGQEELR_.2|_GSLLLGGLDAEASR_.2|_HGELELDIPGAQAR_....

SEN / CTL

P50281

Matrix metalloproteinase-14

MMP14

-3.99

1.75

4.1e-14

1.42e-13

angiogenesis,ovarian follicle development,response...

metalloendopeptidase activity,serine-type endopept...

Golgi lumen,cytosol,plasma membrane,integral compo...

44

15

18

_FYGLQVTGK_.2|_SPQSLSAAIAAMQK_.2|_GLPASINTAYER_.2|...

SEN / CTL

Q9UNN8

Endothelial protein C receptor

PROCR

-4.05

0.88

5.21e-12

1.45e-11

blood coagulation,negative regulation of coagulati...

receptor activity,protein binding

extracellular region,centrosome,plasma membrane,in...

18

5

7

_TLAFPLTIR_.2|_TQSGLQSYLLQFHGLVR_.3|_TQSGLQSYLLQFH...

SEN / CTL

P11717

Cation-independent mannose-6-phosphate receptor

IGF2R

-4.19

0.51

0.0000405

0.0000497

liver development,receptor-mediated endocytosis,si...

glycoprotein binding,G-protein alpha-subunit bindi...

extracellular space,nuclear envelope lumen,lysosom...

7

80

95

_VQSSIAFLC[+57]GK_.2|_SYEEC[+57]IIESR_.2|_TVEAC[+5...

SEN / CTL

P01033

Metalloproteinase inhibitor 1

TIMP1

-4.34

0.62

2.31e-85

9.92e-84

cell activation,platelet degranulation,aging,posit...

protease binding,cytokine activity,protein binding...

extracellular region,proteinaceous extracellular m...

98

7

11

_EPGLC[+57]TWQSLR_.2|_GFQALGDAADIR_.2|_LQSGTHC[+57...

SEN / CTL

P26006

Integrin alpha-3

ITGA3

-4.46

0.37

9.66e-13

2.93e-12

neuron migration,cell-matrix adhesion,integrin-med...

glycoprotein binding,fibronectin binding,protease ...

plasma membrane,focal adhesion,integrin complex,ex...

13

26

39

_YLLLAGAPR_.2|_GNSYMIQR_.2|_AAFVSEQQQK_.2|_SETVLTC...

SEN / CTL

P31431

Syndecan-4

SDC4

-4.52

0.37

2.03e-14

7.42e-14

retinoid metabolic process,ureteric bud developmen...

fibronectin binding,protein kinase C binding,prote...

Golgi lumen,plasma membrane,integral component of ...

13

4

4

_AGSGSQVPTEPK_.2|_KLEENEVIPK_.2|_RISPVEESEDVSNK_.3...

SEN / CTL

P60033

CD81 antigen

CD81

-4.55

0.52

0.00104

0.000978

activation of MAPK activity,cell surface receptor ...

protein binding,MHC class II protein complex bindi...

immunological synapse,plasma membrane,integral com...

4

5

8

_QFYDQALQQAVVDDDANNAK_.3|_QFYDQALQQAVVDDDANNAK_.2|...

SEN / CTL

P08195

4F2 cell-surface antigen heavy chain

SLC3A2

-4.83

0.57

0.0000378

0.0000468

carbohydrate metabolic process,tryptophan cataboli...

RNA binding,double-stranded RNA binding,catalytic ...

nucleus,cytosol,plasma membrane,cell surface,membr...

6

36

56

_LLTSFLPAQLLR_.2|_GQSEDPGSLLSLFR_.2|_VILDLTPNYR_.2...

SEN / CTL

P24821

Tenascin

TNC

-5.04

1.05

2.3e-44

3.29e-43

osteoblast differentiation,cell adhesion,negative ...

syndecan binding

extracellular region,basement membrane,interstitia...

64

77

105

_ITAQGQYELR_.2|_GLEPGQEYNVLLTAEK_.2|_VSIYGVIR_.2|_...

SEN / CTL

P17301

Integrin alpha-2

ITGA2

-5.21

0.54

4.74e-15

1.89e-14

response to hypoxia,positive regulation of leukocy...

virus receptor activity,integrin binding,protein b...

nucleus,plasma membrane,focal adhesion,integrin co...

17

27

31

_ILGSDGAFR_.2|_FGIAVLGYLNR_.2|_FVQGLDIGPTK_.2|_TQV...

SEN / CTL

P05120

Plasminogen activator inhibitor 2

SERPINB2

-5.25

0.28

0.0000172

0.0000224

negative regulation of endopeptidase activity,woun...

serine-type endopeptidase inhibitor activity

extracellular region,extracellular space,cytoplasm...

5

10

11

_GKIPNLLPEGSVDGDTR_.3|_ITNC[+57]ILFFGR_.2|_TPVQMMY...

SEN / CTL

Q92520

Protein FAM3C

FAM3C

-5.48

0.76

1.21e-7

2.19e-7

platelet degranulation,multicellular organism deve...

cytokine activity,protein binding

extracellular region,extracellular space,platelet ...

10

12

17

_DNWVFC[+57]GGK_.2|_TGEVLDTK_.2|_MASGAANVVGPK_.2|_...

SEN / CTL

Q15758

Neutral amino acid transporter B(0)

SLC1A5

-5.65

0.26

0.0273

0.0169

amino acid transmembrane transport,extracellular a...

virus receptor activity,receptor activity,protein ...

plasma membrane,integral component of plasma membr...

2

16

21

_STEPELIQVK_.2|_SELPLDPLPVPTEEGNPLLK_.2|_SELPLDPLP...

SEN / CTL

P18065

Insulin-like growth factor-binding protein 2

IGFBP2

-5.69

2.56

0.086

0.046

regulation of cell growth,signal transduction,fema...

receptor binding,protein binding,insulin-like grow...

extracellular region,extracellular space,apical pl...

11

11

14

_TPC[+57]QQELDQVLER_.2|_LEGEAC[+57]GVYTPR_.2|_LAAC...

SEN / CTL

P21589

5'-nucleotidase

NT5E

-5.86

0.35

0.0443

0.0256

purine nucleotide catabolic process,AMP catabolic ...

nucleotide binding,5'-nucleotidase activity,metal ...

cytosol,plasma membrane,cell surface,membrane,anch...

2

28

42

_TIVYLDGSSQSC[+57]R_.2|_VIYPAVEGR_.2|_MKVIYPAVEGR_...

SEN / CTL

O75326

Semaphorin-7A

SEMA7A

-6.2

0.5

7.68e-34

6.99e-33

osteoblast differentiation,inflammatory response,i...

integrin binding,protein binding,neuropilin bindin...

plasma membrane,external side of plasma membrane,m...

31

6

8

_GDQGGESSLSVSK_.2|_SEGLLAC[+57]GTNAR_.2|_AMLVC[+57...

SEN / CTL

P08648

Integrin alpha-5

ITGA5

-6.25

0.63

4.77e-10

1.15e-9

angiogenesis,cell-substrate junction assembly,cell...

virus receptor activity,epidermal growth factor re...

ruffle,endoplasmic reticulum,Golgi apparatus,plasm...

11

23

32

_ILEYAPC[+57]R_.2|_AGASLWGGLR_.2|_VTAPPEAEYSGLVR_....

SEN / CTL

P03956

Interstitial collagenase

MMP1

-6.57

2.17

9.59e-26

6.85e-25

proteolysis,viral process,extracellular matrix dis...

endopeptidase activity,metalloendopeptidase activi...

extracellular region,proteinaceous extracellular m...

51

6

6

_AFQLWSNVTPLTFTK_.2|_SQNPVQPIGPQTPK_.2|_TYFFVANK_....

SEN / CTL

P52823

Stanniocalcin-1

STC1

-6.59

0.66

3.05e-19

1.67e-18

ossification,endothelial cell morphogenesis,growth...

hormone activity

extracellular space,nucleus,cytoplasm,apical plasm...

19

2

3

_RNPEAITEVVQLPNHFSNR_.3|_IGPNMASLFHILQTDHC[+57]AQT...