Pro-longevity genes in Mus Musculus

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Name of Formulation

Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993


Strain

Significance
(Yes: Y, No: N)

Reference

Rapamycin

128 ppm

36.7


C57BL/6JNia

Y

27549339

Polypeptide
Pineal extract

0.5 mg

31

14


C3H/Sn

Y

6752596

Epithalamin

NA

31


C3H/Sn

Y

9701766

Butylated
hydroxytoluene

0.75%

30.1


BaLB/c

Y

448040

Polypeptide
Bovine Thymus extract

0.5 mg

28

11.2


C3H/Sn

Y

6752596

Rapamycin

42 mg of
drug per kg of food

26

11


UM-HET3

Y

24341993

Rapamycin

8
mg/kg/day

26


C57BL/6JNia

Y

27549339

Butylated
hydroxytoluene

0.75%

24.8


BaLB/c

Y

448040

N-acetyl-L-cysteine

10 g/L of
water

24

45


UM-HET3

Y

20819793

Spermidine

Drinking
water supplemented with 3mM

23.79


C57BL/6

Y

28386016

Royal Jelly

500 ppm ad
libitum in diet

23.6


C3H/HeJ

Y

12954483

Rapamycin

42 mg of
drug per kg of food

23

8


UM-HET3

Y

24341993

Acarbose

1000 mg/kg

22

11


UM-HET3

Y

24245565

Phenformin

2 mg, 5
times a week

21

26


C3H/Sn

Y

14618027

Rapamycin

14 mg of
drug per kg of food

21

11


UM-HET3

Y

24341993

Calcium
Pantothenate

300 µg/day

20.02


C-57 black

Y

13614445

Ethoxyquin

0.5% w/w

19.9


C3H

Y

4927196

17‐α‐estradiol

14.4 ppm
of Chow

19

12


UM-HET3

Y

27312235

Calcium
Pantothenate

300 µg/day

18.3


C-57 black

Y

13614445

Ethoxyquin

0.5% w/w

18.1


C3H

Y

4927196

Melatonin

10
micro-g/ml of water

18.1


BALB/c

Y

8290600

Rapamycin

4.7 mg of
drug per kg of food

16

5


UM-HET3

Y

24341993

Rapamycin

8 mg/kg/day

16


C57BL/6JNia

Y

27549339

Vitamin E

550 mg/kg

15


C57BL/6J

Y

18257658

VI-28

0.0005

14.4


C57BL/6J

Y

20370440

Rapamycin

14 ppm

14


C57BL/6J

Y

24409289

VI-28

0.005

13.5


C57BL/6J

Y

20370440

Rapamycin

2 mg/kg
every 5 days

13

17.6


C57BL/6J.Nia

Y

27091134

Rapamycin

2.24 mg/kg/day

13

14


Hybrid of
CB6F1(F)& C3D2F1(M)

Y

19587680

Rapamycin

14 mg of
drug per kg of food

13

8


UM-HET3

Y

24341993

Branched-Chain
Amino Acids

1.5 mg/g
body weight

12

4.6


B6.129S2

Y

20889128

Nordihydroguaiaretic
acid

2.5 g/kg
food

12


UM-HET3

Y

18631321

Nordihydroguaiaretic
acid

3.5 g/kg
diet

12


B6C3F1

Y

25380600

Tetrahydrocurcumin

0.002

10.7

6.5


C57BL/6J

Y

17516143

Tetrahydrocurcumin

0.002

10.6


Sprague-Dawley

Y

15247057

Spermidine

0.3mM

10.6


C57BL/6J

Y

27841876

Rapamycin

1.5 mg/kg

10.1

9.3


129/Sv

Y

22107964

Metoprolol

1.1 g/kg
diet

10


C3B6F1

Y

23314750

L2-Cmu

20 mg/kg
weekly i.p. injection

9


CB6F1

Y

29921922

Creatine

0.01

8.9

3.5


C57BL/6J

Y

17416441

VI-28

0.0005

8.8


C57BL/6J

Y

20370440

SRT1720

100 mg/kg
body weight

8.8


C57BL/6J

N

24582957

BP-C3

10 mg/kg
Daily

8.4

12.4


Swiss-Derived
SHR

Y

27574962

Aspirin

21 mg/kg
food

8

47.2


UM-HET3

Y

18631321

Icariin

0.02% in
food

8

6


C57BL/6J

N

26145038

Rapamycin

128 ppm

8


C57BL/6JNia

Y

27549339

Rapamycin

128 ppm

8


C57BL/6JNia

Y

27549339

Nordihydroguaiaretic
acid

2.5 g/kg
diet

7.7


B6C3F1

N

25380600

VI-28

0.005

7.2


C57BL/6J

N

20370440

2,4-dinitrophenol

1 mg/L

7.1


Swiss
Webster

Y

18505478

L-deprenyl

0.25 mg/kg
3x/week

7

7.5


B6CBAF1

N

8914495

Protandim

600 ppm in
chow

7

6


UM-HET3

Y

27312235

Rapamycin

14 ppm

7


C57BL/6J

Y

24409289

Green tea
extract

2000 mg/kg
of food

6.6


UM-HET3

N

22451473

Spermidine

3 mM

6.5


C57BL/6J

Y

27841876

Green tea
polyphenols

80 mg/l

6.4

1.3


C57BL/6J

Y

17516143

Green tea
polyphenols

80 mg/L

6.4


Sprague-Dawley

Y

15247057

Nebivolol

0.27 g/kg
diet

6.4


C3B6F1

Y

23314750

Polyphenols

alternate
no food/high-fat chow

6.3


C57BL/6J

Y

22265987

Dasatinib +
Quercetin

5 mg/kg
(Das) + 50 mg/kg (Que)

6.29


C57BL/6

Y

29988130

Ivabradine

50
mg/kg/day

6.2


C57BL/6J

Y

25589054

Dimethylaminoethyl
p-chlorophenoxyacetate

702 µg/mL

5.9

-9.6


C57BL/6J

N

4788962

Metformin

0.1%
(w/w), 100 mg/kg diet

5.8


C57BL/6J

Y

23900241

D-glucosamine

10 g/kg

5.6

5.5


C57BL/6NRj

Y

24714520

Melatonin

20 mg/l

5.4

7.5


CBA

Y

11445596

Acarbose

1000 mg/kg
diet

5

9


UM-HET3

Y

24245565

Aspirin
(Bufferin)

113 µg/mL

5

-6.1


C57BL/6J

N

4788962

Rapamycin

14 ppm

4.8


C57BL/6

Y

23682161

Resveratrol

300 mg/kg
of food

4.7


UM-HET3

N

22451473

Nicotinamide
riboside

400
mg/kg/day

4.7


C57BL/6J

Y

27127236

Green tea
extract

2000 mg/kg
of food

4.6


UM-HET3

N

22451473

Curcumin

2000 mg/kg
of food

4.5


UM-HET3

N

22451473

Oxaloacetate

2200 mg/Kg
of food

4.2


UM-HET3

N

22451473

Icariin in
Epimedium Flavonoid

0.06% in
food

4

3


C57BL/6J

N

26145038

L-deprenyl

0.25 mg/kg
3x/week

3.9

31.2


B6CBAF1

N

8914495

N-tert-butyl-alpha-phenylnitrone

0.25 mg/ml
of water

3.8

5


C57BL/6J

Y

9614711

Acetaminophen

242 µg/mL

3.7

-11


C57BL/6J

N

4788962

Resveratrol

300 mg/kg
of food

3.4


UM-HET3

N

22451473

Rapamycin

4.7 mg of
drug per kg of food

3

6


UM-HET3

N

24341993

Curcumin

2000 mg/kg
of food

2.8


UM-HET3

N

22451473

L-deprenyl

0.25 mg/kg
3x/week

2.7

15.3


B6D2F1

N

8914495

Oxaloacetate

2200 mg/Kg
of food

2.7


UM-HET3

N

22451473

Medium-chain
triglyceride oil

60000
mg/kg of diet

1.8


UM-HET3

N

22451473

Alkaline
Water

1.8


CD1

Y

27340414

Chlorpheniramine

0.762
µg/mL

1.4

-14.7


C57BL/6J

N

4788962

Nordihydroguaiaretic
acid

4.5 g/kg
diet

1.2


B6C3F1

N

25380600

Sodium borate

0.5 mM
(21.6 ppm)

0.8


C57BL/6J

N

7889879

Methylene
blue

27 mg/kg
diet

0.7

6


UM-HET3

Y

24245565

Chloroquine

39.5 µg/mL

0.3

-15


C57BL/6J

N

4788962

Aspirin
(Bufferin)

495 µg/mL

0.1

-4.8


C57BL/6J

N

4788962

Rapamycin

8
mg/kg/day

0


C57BL/6JNia

N

27549339

L-deprenyl

0.25 mg/kg
3x/week

-0.1

-0.7


B6D2F1

N

8914495

Chlorpromazine

16.7 µg/mL

-0.2

5.5


C57BL/6J

N

4788962

Metformin

1% In
Standard Diet Every Other Week

-1

-6


C57BL/6

ND

29167747

Nordihydroguaiaretic
acid

1.5 g/kg
diet

-1


B6C3F1

N

25380600

Medium-chain
triglyceride oil

60000
mg/kg of diet

-1.1


UM-HET3

N

22451473

Sodium
borate

0.1 mM
(4.3 ppm)

-2.9


C57BL/6J

N

7889879

Chlorpheniramine

2.28 µg/mL

-3.3

7.2


C57BL/6J

N

4788962

Metformin

1%in
Standard Diet on 2 Consecutive Weeks Each Month

-5

-3


C57BL/6

ND

29167747

Quercetin

10 mg/day

-5.8


LACA

N

7140862

Quercetin

10 mg/day

-11.6


LACA

Y

7140862

Quercetin

10 mg/day

-14.2


LACA

Y

7140862

Chloroquine

13.2 µg/mL

-16.8

-10.8


C57BL/6J

Y

4788962

Aspirin
(Bufferin)

242 µg/mL

-17.5

-10.1


C57BL/6J

Y

4788962

Echinacea
purpurea root

2 mg/day

28


BALB/cByJ

ND

16041619

Rapamycin

4 mg/kg


C57BL/6J

Y

19934433

Spermine

3
mg.kg-1.dose-1


Crj:CD-1

Y

21858192

Rapamycin

14 mg/kg


C57BL/6J

Y

23863708

Nicotinamide

0.5/kg


C57BL/6J

N

29514072

Nicotinamide

1 g/kg


C57BL/6J

Y

29514072

Nicotinamide
mononucleotide

100
mg/kg/day


C57BL/6N

Y

28068222

Nicotinamide
mononucleotide

300 mg/kg/day


C57BL/6N

N

28068222

Reference: HAGR
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