Pro-longevity genes in Mus Musculus

Name of Formulation Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993

Strain Significance (Yes: Y, No: N) Reference
Rapamycin 128 ppm

36.7

C57BL/6JNia Y 27549339
Polypeptide Pineal extract 0.5 mg

31

14

C3H/Sn Y 6752596
Epithalamin NA

31

C3H/Sn Y 9701766
Butylated hydroxytoluene 0.75%

30.1

BaLB/c Y 448040
Polypeptide Bovine Thymus extract 0.5 mg

28

11.2

C3H/Sn Y 6752596
Rapamycin 42 mg of drug per kg of food

26

11

UM-HET3 Y 24341993
Rapamycin 8 mg/kg/day

26

C57BL/6JNia Y 27549339
Butylated hydroxytoluene 0.75%

24.8

BaLB/c Y 448040
N-acetyl-L-cysteine 10 g/L of water

24

45

UM-HET3 Y 20819793
Spermidine Drinking water supplemented with 3mM

23.79

C57BL/6 Y 28386016
Royal Jelly 500 ppm ad libitum in diet

23.6

C3H/HeJ Y 12954483
Rapamycin 42 mg of drug per kg of food

23

8

UM-HET3 Y 24341993
Acarbose 1000 mg/kg

22

11

UM-HET3 Y 24245565
Phenformin 2 mg, 5 times a week

21

26

C3H/Sn Y 14618027
Rapamycin 14 mg of drug per kg of food

21

11

UM-HET3 Y 24341993
Calcium Pantothenate 300 µg/day

20.02

C-57 black Y 13614445
Ethoxyquin 0.5% w/w

19.9

C3H Y 4927196
17‐α‐estradiol 14.4 ppm of Chow

19

12

UM-HET3 Y 27312235
Calcium Pantothenate 300 µg/day

18.3

C-57 black Y 13614445
Ethoxyquin 0.5% w/w

18.1

C3H Y 4927196
Melatonin 10 micro-g/ml of water

18.1

BALB/c Y 8290600
Rapamycin 4.7 mg of drug per kg of food

16

5

UM-HET3 Y 24341993
Rapamycin 8 mg/kg/day

16

C57BL/6JNia Y 27549339
Vitamin E 550 mg/kg

15

C57BL/6J Y 18257658
VI-28 0.0005

14.4

C57BL/6J Y 20370440
Rapamycin 14 ppm

14

C57BL/6J Y 24409289
VI-28 0.005

13.5

C57BL/6J Y 20370440
Rapamycin 2 mg/kg every 5 days

13

17.6

C57BL/6J.Nia Y 27091134
Rapamycin 2.24 mg/kg/day

13

14

Hybrid of CB6F1(F)& C3D2F1(M) Y 19587680
Rapamycin 14 mg of drug per kg of food

13

8

UM-HET3 Y 24341993
Branched-Chain Amino Acids 1.5 mg/g body weight

12

4.6

B6.129S2 Y 20889128
Nordihydroguaiaretic acid 2.5 g/kg food

12

UM-HET3 Y 18631321
Nordihydroguaiaretic acid 3.5 g/kg diet

12

B6C3F1 Y 25380600
Tetrahydrocurcumin 0.002

10.7

6.5

C57BL/6J Y 17516143
Tetrahydrocurcumin 0.002

10.6

Sprague-Dawley Y 15247057
Spermidine 0.3mM

10.6

C57BL/6J Y 27841876
Rapamycin 1.5 mg/kg

10.1

9.3

129/Sv Y 22107964
Metoprolol 1.1 g/kg diet

10

C3B6F1 Y 23314750
L2-Cmu 20 mg/kg weekly i.p. injection

9

CB6F1 Y 29921922
Creatine 0.01

8.9

3.5

C57BL/6J Y 17416441
VI-28 0.0005

8.8

C57BL/6J Y 20370440
SRT1720 100 mg/kg body weight

8.8

C57BL/6J N 24582957
BP-C3 10 mg/kg Daily

8.4

12.4

Swiss-Derived SHR Y 27574962
Aspirin 21 mg/kg food

8

47.2

UM-HET3 Y 18631321
Icariin 0.02% in food

8

6

C57BL/6J N 26145038
Rapamycin 128 ppm

8

C57BL/6JNia Y 27549339
Rapamycin 128 ppm

8

C57BL/6JNia Y 27549339
Nordihydroguaiaretic acid 2.5 g/kg diet

7.7

B6C3F1 N 25380600
VI-28 0.005

7.2

C57BL/6J N 20370440
2,4-dinitrophenol 1 mg/L

7.1

Swiss Webster Y 18505478
L-deprenyl 0.25 mg/kg 3x/week

7

7.5

B6CBAF1 N 8914495
Protandim 600 ppm in chow

7

6

UM-HET3 Y 27312235
Rapamycin 14 ppm

7

C57BL/6J Y 24409289
Green tea extract 2000 mg/kg of food

6.6

UM-HET3 N 22451473
Spermidine 3 mM

6.5

C57BL/6J Y 27841876
Green tea polyphenols 80 mg/l

6.4

1.3

C57BL/6J Y 17516143
Green tea polyphenols 80 mg/L

6.4

Sprague-Dawley Y 15247057
Nebivolol 0.27 g/kg diet

6.4

C3B6F1 Y 23314750
Polyphenols alternate no food/high-fat chow

6.3

C57BL/6J Y 22265987
Dasatinib + Quercetin 5 mg/kg (Das) + 50 mg/kg (Que)

6.29

C57BL/6 Y 29988130
Ivabradine 50 mg/kg/day

6.2

C57BL/6J Y 25589054
Dimethylaminoethyl p-chlorophenoxyacetate 702 µg/mL

5.9

-9.6

C57BL/6J N 4788962
Metformin 0.1% (w/w), 100 mg/kg diet

5.8

C57BL/6J Y 23900241
D-glucosamine 10 g/kg

5.6

5.5

C57BL/6NRj Y 24714520
Melatonin 20 mg/l

5.4

7.5

CBA Y 11445596
Acarbose 1000 mg/kg diet

5

9

UM-HET3 Y 24245565
Aspirin (Bufferin) 113 µg/mL

5

-6.1

C57BL/6J N 4788962
Rapamycin 14 ppm

4.8

C57BL/6 Y 23682161
Resveratrol 300 mg/kg of food

4.7

UM-HET3 N 22451473
Nicotinamide riboside 400 mg/kg/day

4.7

C57BL/6J Y 27127236
Green tea extract 2000 mg/kg of food

4.6

UM-HET3 N 22451473
Curcumin 2000 mg/kg of food

4.5

UM-HET3 N 22451473
Oxaloacetate 2200 mg/Kg of food

4.2

UM-HET3 N 22451473
Icariin in Epimedium Flavonoid 0.06% in food

4

3

C57BL/6J N 26145038
L-deprenyl 0.25 mg/kg 3x/week

3.9

31.2

B6CBAF1 N 8914495
N-tert-butyl-alpha-phenylnitrone 0.25 mg/ml of water

3.8

5

C57BL/6J Y 9614711
Acetaminophen 242 µg/mL

3.7

-11

C57BL/6J N 4788962
Resveratrol 300 mg/kg of food

3.4

UM-HET3 N 22451473
Rapamycin 4.7 mg of drug per kg of food

3

6

UM-HET3 N 24341993
Curcumin 2000 mg/kg of food

2.8

UM-HET3 N 22451473
L-deprenyl 0.25 mg/kg 3x/week

2.7

15.3

B6D2F1 N 8914495
Oxaloacetate 2200 mg/Kg of food

2.7

UM-HET3 N 22451473
Medium-chain triglyceride oil 60000 mg/kg of diet

1.8

UM-HET3 N 22451473
Alkaline Water

1.8

CD1 Y 27340414
Chlorpheniramine 0.762 µg/mL

1.4

-14.7

C57BL/6J N 4788962
Nordihydroguaiaretic acid 4.5 g/kg diet

1.2

B6C3F1 N 25380600
Sodium borate 0.5 mM (21.6 ppm)

0.8

C57BL/6J N 7889879
Methylene blue 27 mg/kg diet

0.7

6

UM-HET3 Y 24245565
Chloroquine 39.5 µg/mL

0.3

-15

C57BL/6J N 4788962
Aspirin (Bufferin) 495 µg/mL

0.1

-4.8

C57BL/6J N 4788962
Rapamycin 8 mg/kg/day

0

C57BL/6JNia N 27549339
L-deprenyl 0.25 mg/kg 3x/week

-0.1

-0.7

B6D2F1 N 8914495
Chlorpromazine 16.7 µg/mL

-0.2

5.5

C57BL/6J N 4788962
Metformin 1% In Standard Diet Every Other Week

-1

-6

C57BL/6 ND 29167747
Nordihydroguaiaretic acid 1.5 g/kg diet

-1

B6C3F1 N 25380600
Medium-chain triglyceride oil 60000 mg/kg of diet

-1.1

UM-HET3 N 22451473
Sodium borate 0.1 mM (4.3 ppm)

-2.9

C57BL/6J N 7889879
Chlorpheniramine 2.28 µg/mL

-3.3

7.2

C57BL/6J N 4788962
Metformin 1%in Standard Diet on 2 Consecutive Weeks Each Month

-5

-3

C57BL/6 ND 29167747
Quercetin 10 mg/day

-5.8

LACA N 7140862
Quercetin 10 mg/day

-11.6

LACA Y 7140862
Quercetin 10 mg/day

-14.2

LACA Y 7140862
Chloroquine 13.2 µg/mL

-16.8

-10.8

C57BL/6J Y 4788962
Aspirin (Bufferin) 242 µg/mL

-17.5

-10.1

C57BL/6J Y 4788962
Echinacea purpurea root 2 mg/day

28

BALB/cByJ ND 16041619
Rapamycin 4 mg/kg C57BL/6J Y 19934433
Spermine 3 mg.kg-1.dose-1 Crj:CD-1 Y 21858192
Rapamycin 14 mg/kg C57BL/6J Y 23863708
Nicotinamide 0.5/kg C57BL/6J N 29514072
Nicotinamide 1 g/kg C57BL/6J Y 29514072
Nicotinamide mononucleotide 100 mg/kg/day C57BL/6N Y 28068222
Nicotinamide mononucleotide 300 mg/kg/day C57BL/6N N 28068222
Reference: HAGR