Pro-longevity genes in Drosophila Melanogaster

Name

Symbol

Entrez ID

Max average lifespan change

AMP-Activated Kinase

aak-2

181727

Upregulated and Downregulated

AMP-Activated Kinase Beta subunit

aakb-1

181492

Downregulated

AMP-Activated Kinase Beta subunit

aakb-2

176552

Downregulated

Protein AAKG-2

aakg-2

181736

47%  Upregulatedd

Activated in Blocked Unfolded protein response

abu-11

173404

28%  Upregulatedd

Protein ACS-20

acs-20

178190

50%  Downregulated

Adenosine Deaminase that acts on RNA

adr-1

172542

50%  Downregulated

Adenosine Deaminase that acts on RNA

adr-2

176022

50%  Downregulated

Protein AGMO-1

agmo-1

176695

30%  Downregulated

Protein AHA-1

aha-1

172889

10%  Downregulated

ALG-1 INteracting protein

ain-1

181719

10%  Downregulated

Arsenite Inducible Protein

aip-1

179898

50%  Downregulated

Argonaute (plant)-Like Gene

alg-2

173468

24%  Downregulated

ALdehyde deHydrogenase

alh-6

173510

Upregulated and Downregulated

Beta-amyloid-like protein

apl-1

180783

30%  Upregulatedd

APYrase

apy-1

181019

Downregulated

Arginine Kinase

argk-1

180080

25%  Upregulatedd

ARF-Like

arl-8

178405

Downregulated

ARp2/3 compleX component

arx-4

175247

Downregulated

Autophagy (yeast Atg homolog)

atg-18

179246

20%  Downregulated

Autophagy (yeast Atg homolog)

atg-3

176921

Downregulated

Autophagy (yeast Atg homolog)

atg-4.1

190777

Downregulated

Autophagy (yeast Atg homolog)

atg-4.2

3565022

Downregulated

Autophagy (yeast Atg homolog)

atg-5

171735

Downregulated

Autophagy (yeast Atg homolog)

atg-7

178005

Upregulatedd

Autophagy (yeast Atg homolog)

atg-9

178561

Upregulated and Downregulated

Barrier to Autointegration Factor

baf-1

176330

28%  Downregulated

beta-catenin

bar-1

180982

45%  Downregulated

BEClin (human autophagy) homolog

bec-1

177345

40%  Downregulated

BET-1

bet-1

172054

Downregulated

Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog

blmp-1

172917

20%  Downregulated

Kinesin-like protein

bmk-1

179948

25%  Upregulatedd

BMP receptor Associated protein family

bra-1

181481

25%  Downregulated

Protein BUS-4

bus-4

188726

10%  Downregulated

Bacterially Un-Swollen (M. nematophilum resistant)

bus-8

180821

58%  Downregulated

Protein C01F1.1

C01F1.1

173764

28%  Downregulated

Protein C06A5.1

C06A5.1

182280

39%  Downregulated

Protein C07A9.2

C07A9.2

176368

26%  Downregulated

Protein C11H1.3

C11H1.3

181537

10%  Downregulated

Protein C14A4.9

C14A4.9

174637

14%  Downregulated

Protein C26B9.3

C26B9.3

180804

12%  Downregulated

Protein C29F9.1

C29F9.1

175180

Downregulated

Protein C29F9.2

C29F9.2

175179

12%  Downregulated

Protein C33H5.18

C33H5.18

3565046

44%  Downregulated

CALUmenin (calcium-binding protein) homolog

calu-1

180769

Downregulated

Cystathionine Beta-Synthase

cbs-1

181215

50%  Upregulatedd

CCR (yeast CCR4/NOT complex component) homolog

ccr-4

178184

33%  Downregulated

Cyclin-Dependent Kinase family

cdk-7

171784

Downregulated

Protein CDTL-7

cdtl-7

175559

22%  Downregulated

Ceh-10 Homeobox

ceh-10

175811

40%  Downregulated

Protein CEH-20

ceh-20

3565545

12%  Downregulated

Protein CEH-23

ceh-23

176096

25%  Upregulatedd

Protein CEH-37

ceh-37

181530

8%  Downregulated

mRNA Capping Enzyme Like

cel-1

172814

59%  Downregulated

Protein F40F12.7

CELE_F40F12.7

176402

Downregulated

Protein F43D2.1

CELE_F43D2.1

185704

20%  Downregulated

Protein F52C6.2

CELE_F52C6.2

173558

19%  Downregulated

Protein F59B2.8

CELE_F59B2.8

186593

Downregulated

Protein Y47G6A.18

CELE_Y47G6A.18

171919

Downregulated

hypothetical protein

CELE_Y52B11A.9

173005

20%  Downregulated

Clathrin Heavy Chain

chc-1

176434

40%  Downregulated

CyclIn T

cit-1.2

176126

Downregulated

Clock (biological timing) abnormality

clk-2

176065

25%  Upregulatedd

Caenorhabditis STE20-like kinase

cst-1

180708

Upregulated and Downregulated

CystaTHionine gamma lyase

cth-1

180079

15%  Downregulated

Putative cystathionine gamma-lyase 2

cth-2

174155

25%  Downregulated

CU (copper) ATPase

cua-1

176770

12%  Downregulated

CULlin

cul-1

176466

Downregulated

Coelomocyte UPtake defective

cup-4

176104

10%  Downregulated

CYtochrome P450 family

cyp-42A1

180236

39%  Downregulated

D1069.3b

D1069.3

173425

Downregulated

Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)

daf-16

172981

45%  Downregulated

Abnormal dauer Formation

daf-18

176869

Upregulated and Downregulated

Abnormal dauer Formation

daf-28

191014

15%  Upregulatedd

Abnormal dauer Formation

daf-5

175054

20%  Downregulated

DiAcylGlycerol Lipase homolog

dagl-2

3565075

13%  Upregulatedd

Endoribonuclease dcr-1

dcr-1

176138

Downregulated

DAF-16/FOXO Controlled, germline Tumor affecting

dct-11

189237

10%  Downregulated

DAF-16/FOXO Controlled, germline Tumor affecting

dct-18

174934

8%  Downregulated

DeHydrogenases, Short chain

dhs-21

179741

Downregulated

DAF-12 Interacting Protein

din-1

174782

Downregulated

DIS3 (yeast disjunction abnormal) exonuclease homolog

dis-3

177875

11%  Downregulated

DAP (Death Associated Protein kinase) Like Kinase

dlk-1

173128

Downregulated

Mitochondrial import inner membrane translocase subunit TIM14

dnj-21

172231

10%  Downregulated

Protein DPY-27

dpy-27

175492

24%  Downregulated

DVE (Defective proVEntriculus in Drosophila) homolog

dve-1

180398

53%  Downregulated

Protein E01B7.1

E01B7.1

180175

Downregulated

Probable mitochondrial import inner membrane translocase subunit Tim17

E04A4.5

177242

8%  Downregulated

hypothetical protein

eak-7

3564920

30%  Upregulatedd

Elongation Factor

eef-2

172743

Upregulated and Downregulated

Protein EGL-27

egl-27

174121

18%  Upregulatedd

fatty acid ELOngation

elo-5

177320

45%  Downregulated

Enhanced RNAI (RNA interference)

eri-1

176868

43%  Downregulated

Protein ETS-9

ets-9

180702

23%  Downregulated

EXOnuclease

exo-3

173069

20%  Downregulated

Protein F33H2.8

F33H2.8

185238

36%  Downregulated

Protein F37C4.4

F37C4.4

177145

Downregulated

Mitochondrial import inner membrane translocase subunit tim-16

F45G2.8

176769

8%  Downregulated

F56H1.7

F56H1.7

6418597

25%  Downregulated

FATty acid desaturase

fat-7

179100

Downregulated

F-box A protein

fbxa-121

189476

Downregulated

Dimethylaniline monooxygenase [N-oxide-forming]

fmo-2

177958

20%  Upregulatedd

FRataxin (involved in human Friedrich's ataxia) Homolog

frh-1

174002

Upregulated and Downregulated

Fourteen-Three-Three family

ftt-2

181348

Upregulated and Downregulated

General Anaesthetic Sensitivity abnormal

gas-1

181646

Downregulated

GDI (RabGDP Dissociation Inhibitor) family

gdi-1

178402

Downregulated

Protein GEI-4

gei-4

175195

27%  Downregulated

GaLactoFuranose synthesis (UGM, UDP-galactopyranose mutase)

glf-1

177358

49%  Downregulated

G protein,O, Alpha subunit

goa-1

172505

33%  Downregulated

G Protein, Alpha subunit

gpa-10

179075

10%  Downregulated

G Protein, Alpha subunit

gpa-11

173759

25%  Upregulatedd

G Protein, Alpha subunit

gpa-2

179219

Upregulated and Downregulated

G Protein, Alpha subunit

gpa-3

179319

15%  Downregulated

G Protein, Alpha subunit

gpa-9

191659

 

Abnormal growth rate

gro-1

175725

29%  Upregulatedd

G protein, Subunit Alpha

gsa-1

171687

84%  Downregulated

Glutathione S-Transferase

gst-10

178725

Upregulated and Downregulated

Glutathione S-Transferase

gst-5

187537

Downregulated

Spliceosome RNA helicase DDX39B homolog

hel-1

174333

9%  Downregulated

HIF (Hypoxia Inducible Factor) homologa

hif-1

180359

34%  Upregulatedd

High Incidence of Males (increased X chromosome loss)

him-6

178201

Downregulated

HIStone

his-71

181057

19%  Downregulated

Protein HLB-1

hlb-1

181499

Downregulated

Helix Loop Helix

hlh-30

177157

20%  Upregulatedd

Homeodomain interacting Protein Kinase

hpk-1

180695

37%  Downregulated

Protein HPO-31

hpo-31

3565786

52%  Downregulated

Heat shock transcription factor 1

hsf-1

173078

Upregulated and Downregulated

Heat Shock Protein

hsp-12.6

177778

16%  Downregulated

Heat Shock Protein

hsp-16.1

179286

Upregulated and Downregulated

Heat Shock Protein

hsp-16.48

179287

Upregulatedd

Heat Shock Protein

hsp-16.49

179288

Upregulated and Downregulated

Heat Shock Protein

hsp-4

174203

Downregulated

Heat shock 70kDa protein 9B (mortalin-2)

hsp-6

178873

Upregulated and Downregulated

Homolog of Yeast Longevity gene

hyl-1

177660

10%  Downregulated

INitiation Factor

inf-1

175966

Upregulated and Downregulated

INSulin related

ins-1

177936

25%  Upregulatedd

IRE1 kinase related

ire-1

174305

20%  Downregulated

Inositol Triphosphate Receptor

itr-1

177546

53%  Upregulatedd

JNK Kinase

jkk-1

180810

Downregulated

Jun N-terminal Kinase

jnk-1

177460

Upregulated and Downregulated

Protein K11D12.9

K11D12.9

178892

Downregulated

3-Ketoacyl-coA Thiolase

kat-1

174161

30%  Downregulated

Kruppel-Like Factor (zinc finger protein)

klf-1

175404

15%  Upregulatedd

hypothetical protein

klo-1

177557

15%  Downregulated

hypothetical protein

klo-2

184000

15%  Downregulated

human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog

kri-1

191275

Downregulated

LAG1 (yeast Longevity-Assurance Gene) Related

lagr-1

189370

10%  Downregulated

Lipid Binding Protein

lbp-4

179161

Downregulated

Lipid Binding Protein

lbp-6

172390

Upregulated and Downregulated

Lipid Binding Protein

lbp-8

188761

30%  Upregulatedd

Lipid Binding Protein

lbp-9

178686

Downregulated

LIM domain Binding Protein

ldb-1

181292

Downregulated

LEM domain protein

lem-2

175058

Downregulated

LEThal

let-23

174462

Upregulated and Downregulated

LEThal

let-502

172088

30%  Downregulated

LEThal

let-60

178104

Upregulatedd

LEThal

let-653

178120

13%  Downregulated

LEThal

let-765

175934

27%  Downregulated

LC3, GABARAP and GATE-16 family

lgg-1

174050

43%  Downregulated

Protein LIN-11

lin-11

172893

9%  Downregulated

Abnormal cell lineage

lin-15B

181662

42%  Downregulated

Abnormal cell LINeage

lin-2

181400

Upregulatedd

Abnormal cell lineage

lin-23

174058

Downregulated

Abnormal cell lineage

lin-3

178001

Downregulated

Abnormal cell lineage

lin-4

266860

 

Abnormal cell LINeage

lin-40

178788

Upregulated and Downregulated

hypothetical protein

lin-65

171739

24%  Downregulated

LIPase Like

lipl-4

179046

55%  Upregulatedd

nuclear LaMiN

lmn-1

172687

12%  Downregulated

Protein LPR-5

lpr-5

181297

16%  Downregulated

LSM Sm-like protein

lsm-7

177988

24%  Downregulated

LYSozyme

lys-8

173944

29%  Downregulated

Protein M05B5.2

M05B5.2

187451

45%  Downregulated

Protein M57.2

M57.2

177113

20%  Downregulated

Drosophila MAGonashi homolog

mag-1

173073

15%  Downregulated

Protein MBOA-1

mboa-1

181681

16%  Downregulated

yeast MCM (licensing factor) related

mcm-2

174841

Upregulated and Downregulated

Malate DeHydrogenase

mdh-2

175936

10%  Downregulated

Mediator of RNA polymerase II transcription subunit 15

mdt-15

175817

34%  Downregulated

Protein MDT-26

mdt-26

173960

Downregulated

MEChanosensory abnormality

mec-8

172771

Upregulatedd

Dual specificity mitogen-activated protein kinase kinase mek-2

mek-2

171872

10%  Downregulated

Mog interacting, Ectopic P granules

mep-1

178074

8%  Downregulated

Histone-lysine N-methyltransferase met-2

met-2

176183

23%  Downregulated

Abnormal methyl Viologen sensitivity

mev-1

260040

Downregulated

mir-124

mir-124

3565990

16%  Upregulatedd

mir-238

mir-238

3565806

19%  Downregulated

mir-246

mir-246

3565660

10%  Downregulated

mir-71

mir-71

260100

48%  Downregulated

Myc and Mondo-Like

mml-1

176050

10%  Downregulated

MAP kinase iNtegrating Kinase (MNK) homolog

mnk-1

174623

Downregulated

Modulation Of locomotion Defective

mod-5

171879

Downregulated

MAP Kinase

mpk-1

175545

16%  Downregulated

MTM (myotubularin) famil

mtm-3

175490

Downregulated

Y42G9A.4b

mvk-1

175863

14%  Downregulated

MaX-Like

mxl-2

175184

7%  Downregulated

Nuclear Cap-Binding Protein

ncbp-2

184953

24%  Downregulated

NFI (Nuclear Factor I) family

nfi-1

174225

Downregulated

Protein NHR-119

nhr-119

187340

10%  Downregulated

Protein NHR-25

nhr-25

181432

8%  Downregulated

Nuclear Hormone Receptor family

nhr-49

172839

56%  Downregulated

Protein NHR-77

nhr-77

191726

7%  Downregulated

Nuclear hormone receptor family member nhr-8

nhr-8

177551

35%  Downregulated

Neuropeptide-like protein genes family

nlp-7

184647

10%  Downregulated

Nicotinamide Nucleotide Transhydrogenase

nnt-1

180884

18%  Downregulated

Nuclear Pore complex Protein

npp-2

172611

11%  Downregulated

Nuclear Pore complex Protein

npp-3

174823

14%  Downregulated

Protein NSTP-3

nstp-3

191128

29%  Downregulated

NOT-Like (yeast CCR4/NOT complex component)

ntl-3

176614

Downregulated

NUclear localized Metal Responsive

numr-1

176048

Upregulatedd

NUclear localized Metal Responsive

numr-2

176049

Upregulatedd

Overexpression Longevity Determinant

old-1

191737

65%  Upregulatedd

Serine/threonine-protein kinase pak-1

pak-1

180873

50%  Upregulatedd

Abnormal embryonic PARtitioning of cytoplasm

par-5

178113

Upregulated and Downregulated

PArtner of DroSHa (DRSH-1 interactor)

pash-1

172950

31%  Downregulated

Paralysed Arrest at Two-fold

pat-10

172127

30%  Upregulatedd

Protein PAT-3

pat-3

175504

28%  Downregulated

Proteasome subunit beta type

pbs-5

173334

25%  Upregulatedd

Protein PCF-11

pcf-11

246008

19%  Downregulated

Putative pachytene checkpoint protein 2

pch-2

174313

22%  Upregulatedd

Protein Carboxymethyltransferase

pcm-1

178981

30%  Upregulatedd

Pyruvate Dehydrogenase Phosphatase homolog

pdp-1

172035

17%  Upregulatedd

defective PHArynx development

pha-4

180357

13%  Downregulated

mitochondrial ProHiBitin complex

phb-1

171768

Downregulated

mitochondrial ProHiBitin complex

phb-2

174034

Downregulated

Pyrazinamidase and NiCotinamidase

pnc-1

176833

Downregulated

PaNtothenate Kinase

pnk-1

172327

Downregulated

PeRoxireDoXin

prdx-2

266858

Downregulated

PeRoxireDoXin

prdx-3

175573

Downregulated

PaTched Related family

ptr-23

173362

13%  Downregulated

Protein R12B2.6

R12B2.6

187837

22%  Downregulated

RAB family

rab-5

172755

50%  Downregulated

RAB family

rab-7

174834

32%  Downregulated

RB (Retinoblastoma Binding protein) Related

rbr-2

177985

Upregulated and Downregulated

ReCQ DNA helicase family

rcq-5

175522

37%  Downregulated

RHo GDI

rhi-1

180721

Downregulated

hypothetical protein

rict-1

3565035

10%  Upregulatedd

Protein RPN-11

rpn-11

173744

19%  Downregulated

Protein RPN-6.1

rpn-6.1

175972

Downregulated

Protein RPT-1

rpt-1

179641

28%  Downregulated

SR protein related

rsr-2

174862

Downregulated

Protein SAC-1

sac-1

172778

25%  Downregulated

Shwachman-Bodian-Diamond Syndrome protein homolog

sbds-1

175218

Downregulated

Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog

sbt-1

180366

Downregulated

Suppressor of Constitutive Dauer formation

scd-2

179054

Downregulated

SCP-Like extracellular protein

scl-1

186053

Downregulated

SCP-Like extracellular protein

scl-20

191309

18%  Downregulated

SERotonin/octopamine receptor family

ser-4

175322

Downregulated

Sestrin homolog

sesn-1

171593

Upregulated and Downregulated

SET (trithorax/polycomb) domain containing

set-6

181371

10%  Downregulated

Src Homology domain C-terminal, adaptor homolog

shc-1

3565745

38%  Downregulated

Stress-induced protein 1

sip-1

176471

18%  Downregulated

Yeast SIR related (68.8 kD) (sir-2.1)

sir-2.1

177924

Upregulated and Downregulated

SKiNhead

skn-1

177343

Upregulated and Downregulated

SKp1 Related (ubiquitin ligase complex component)

skr-1

172775

Downregulated

SKp1 Related (ubiquitin ligase complex component)

skr-2

172773

Downregulated

suppressor of MEK null

smk-1

179243

21%  Downregulated

SMN (human Survival Motor Neuron gene) homolog

smn-1

172783

26%  Downregulated

Protein SNAP-1

snap-1

179193

40%  Downregulated

Protein SNAP-29

snap-29

176233

49%  Downregulated

synuclein, alpha (non A4 component of amyloid precursor)

SNCA

 

25%  Upregulated >

Superoxide dismutase (24.5 kD) (sod-2)

sod-2

172632

44%  Upregulatedd

Sphingosine Phosphate Lyase

spl-1

176857

22%  Downregulated

Specificity Protein) Transcription Factor

sptf-3

189783

24%  Downregulated

SYnapse Defective

syd-2

181255

Downregulated

Protein T19B10.2

T19B10.2

179551

34%  Downregulated

Protein T27F7.1

T27F7.1

173863

34%  Downregulated

TBC (Tre-2/Bub2/Cdc16) domain family

tbc-7

180784

Downregulated

TATA-Binding Protein

tbp-1

176054

21%  Downregulated

TransCription Elongation Regulator homolog

tcer-1

174150

15%  Upregulatedd

Translocase, Inner Mitochondrial Membrane

timm-23

173041

7%  Downregulated

Probable mitochondrial import inner membrane translocase subunit tim-44

tin-44

172302

11%  Downregulated

TBP-Like Factor

tlf-1

172676

33%  Downregulated

K02G10.3

tmem-135

180740

Downregulated

TOMosyn synaptic protein

tom-1

172209

33%  Downregulated

Translocase of Outer Mitochondrial Membrane

tomm-22

173436

14%  Downregulated

TOPoisomerase

top-1

266847

19%  Downregulated

Protein TRPA-1

trpa-1

178118

34%  Upregulatedd

ThioRedoXin

trx-1

181863

Downregulated

Protein TTX-1

ttx-1

180313

25%  Downregulated

Abnormal thermotaxis

ttx-3

181357

10%  Downregulated

UBiquitin Conjugating enzyme

ubc-13

177073

Downregulated

UBiquitin C-terminal Hydrolase (family 1)

ubh-1

179039

Downregulated

UBiquitin C-terminal Hydrolase (family 1)

ubh-3

259626

Downregulated

Ubiquitin Fusion Degradation (yeast UFD homolog)

ufd-1

3565860

64%  Downregulated

Ubiquitin-Like Protease

ulp-1

175704

22%  Downregulated

UNCoordinated

unc-4

174544

100%  Upregulatedd

UNCoordinated

unc-51

180311

Upregulated and Downregulated

UNCoordinated

unc-60

178640

Downregulated

UNCoordinated

unc-64

176743

Upregulatedd

UNCoordinated

unc-76

180014

50%  Upregulatedd

Protein USP-48

usp-48

172782

Downregulated

Variable ABnormal morphology

vab-1

173794

20%  Upregulatedd

related to yeast Vacuolar Protein Sorting factor

vps-16

175913

21%  Downregulated

Protein VPS-20

vps-20

171654

Downregulated

Protein VPS-22

vps-22

175672

43%  Downregulated

Vacuolar sorting protein

vps-33.1

176221

15%  Downregulated

VPS-36

vps-36

179520

27%  Downregulated

related to yeast Vacuolar Protein Sorting factor

vps-37

178944

44%  Downregulated

Vaccinia Related Kinase

vrk-1

174004

36%  Downregulated

Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment

wip-1

175681

Downregulated

WW domain Protein (E3 ubiquitin ligase)

wwp-1

171647

Upregulated and Downregulated

Protein XBP-1

xbp-1

175541

 

Y46G5A.6 pseudogene

Y46G5A.6

189958

Downregulated

hypothetical protein

Y47D3A.29

176544

22%  Downregulated

Protein Y55F3AM.3

Y55F3AM.3

176922

9%  Downregulated

Y77E11A.7b

Y77E11A.7

176951

24%  Downregulated

Co-chaperone protein daf-41

ZC395.10

175727

 

Protein ZFH-2

zfh-2

171670

45%  Downregulated

Zinc Finger Protein

zfp-1

176237

Downregulated

Zinc finger Transcription Factor family

ztf-12

179257

Downregulated

Reference: HAGR