Pro-longevity genes in Drosophila Melanogaster

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Name


Symbol


Entrez ID


Max average lifespan change


AMP-Activated Kinase


aak-2


181727


Upregulated and Downregulated


AMP-Activated Kinase Beta subunit


aakb-1


181492


Downregulated


AMP-Activated Kinase Beta subunit


aakb-2


176552


Downregulated


Protein AAKG-2


aakg-2


181736


47%  Upregulatedd


Activated in Blocked Unfolded protein response


abu-11


173404


28%  Upregulatedd


Protein ACS-20


acs-20


178190


50%  Downregulated


Adenosine Deaminase that acts on RNA


adr-1


172542


50%  Downregulated


Adenosine Deaminase that acts on RNA


adr-2


176022


50%  Downregulated


Protein AGMO-1


agmo-1


176695


30%  Downregulated


Protein AHA-1


aha-1


172889


10%  Downregulated


ALG-1 INteracting protein


ain-1


181719


10%  Downregulated


Arsenite Inducible Protein


aip-1


179898


50%  Downregulated


Argonaute (plant)-Like Gene


alg-2


173468


24%  Downregulated


ALdehyde deHydrogenase


alh-6


173510


Upregulated and Downregulated


Beta-amyloid-like protein


apl-1


180783


30%  Upregulatedd


APYrase


apy-1


181019


Downregulated


Arginine Kinase


argk-1


180080


25%  Upregulatedd


ARF-Like


arl-8


178405


Downregulated


ARp2/3 compleX component


arx-4


175247


Downregulated


Autophagy (yeast Atg homolog)


atg-18


179246


20%  Downregulated


Autophagy (yeast Atg homolog)


atg-3


176921


Downregulated


Autophagy (yeast Atg homolog)


atg-4.1


190777


Downregulated


Autophagy (yeast Atg homolog)


atg-4.2


3565022


Downregulated


Autophagy (yeast Atg homolog)


atg-5


171735


Downregulated


Autophagy (yeast Atg homolog)


atg-7


178005


Upregulatedd


Autophagy (yeast Atg homolog)


atg-9


178561


Upregulated and Downregulated


Barrier to Autointegration Factor


baf-1


176330


28%  Downregulated


beta-catenin


bar-1


180982


45%  Downregulated


BEClin (human autophagy) homolog


bec-1


177345


40%  Downregulated


BET-1


bet-1


172054


Downregulated


Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog


blmp-1


172917


20%  Downregulated


Kinesin-like protein


bmk-1


179948


25%  Upregulatedd


BMP receptor Associated protein family


bra-1


181481


25%  Downregulated


Protein BUS-4


bus-4


188726


10%  Downregulated


Bacterially Un-Swollen (M. nematophilum resistant)


bus-8


180821


58%  Downregulated


Protein C01F1.1


C01F1.1


173764


28%  Downregulated


Protein C06A5.1


C06A5.1


182280


39%  Downregulated


Protein C07A9.2


C07A9.2


176368


26%  Downregulated


Protein C11H1.3


C11H1.3


181537


10%  Downregulated


Protein C14A4.9


C14A4.9


174637


14%  Downregulated


Protein C26B9.3


C26B9.3


180804


12%  Downregulated


Protein C29F9.1


C29F9.1


175180


Downregulated


Protein C29F9.2


C29F9.2


175179


12%  Downregulated


Protein C33H5.18


C33H5.18


3565046


44%  Downregulated


CALUmenin (calcium-binding protein) homolog


calu-1


180769


Downregulated


Cystathionine Beta-Synthase


cbs-1


181215


50%  Upregulatedd


CCR (yeast CCR4/NOT complex component) homolog


ccr-4


178184


33%  Downregulated


Cyclin-Dependent Kinase family


cdk-7


171784


Downregulated


Protein CDTL-7


cdtl-7


175559


22%  Downregulated


Ceh-10 Homeobox


ceh-10


175811


40%  Downregulated


Protein CEH-20


ceh-20


3565545


12%  Downregulated


Protein CEH-23


ceh-23


176096


25%  Upregulatedd


Protein CEH-37


ceh-37


181530


8%  Downregulated


mRNA Capping Enzyme Like


cel-1


172814


59%  Downregulated


Protein F40F12.7


CELE_F40F12.7


176402


Downregulated


Protein F43D2.1


CELE_F43D2.1


185704


20%  Downregulated


Protein F52C6.2


CELE_F52C6.2


173558


19%  Downregulated


Protein F59B2.8


CELE_F59B2.8


186593


Downregulated


Protein Y47G6A.18


CELE_Y47G6A.18


171919


Downregulated


hypothetical protein


CELE_Y52B11A.9


173005


20%  Downregulated


Clathrin Heavy Chain


chc-1


176434


40%  Downregulated


CyclIn T


cit-1.2


176126


Downregulated


Clock (biological timing) abnormality


clk-2


176065


25%  Upregulatedd


Caenorhabditis STE20-like kinase


cst-1


180708


Upregulated and Downregulated


CystaTHionine gamma lyase


cth-1


180079


15%  Downregulated


Putative cystathionine gamma-lyase 2


cth-2


174155


25%  Downregulated


CU (copper) ATPase


cua-1


176770


12%  Downregulated


CULlin


cul-1


176466


Downregulated


Coelomocyte UPtake defective


cup-4


176104


10%  Downregulated


CYtochrome P450 family


cyp-42A1


180236


39%  Downregulated


D1069.3b


D1069.3


173425


Downregulated


Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)


daf-16


172981


45%  Downregulated


Abnormal dauer Formation


daf-18


176869


Upregulated and Downregulated


Abnormal dauer Formation


daf-28


191014


15%  Upregulatedd


Abnormal dauer Formation


daf-5


175054


20%  Downregulated


DiAcylGlycerol Lipase homolog


dagl-2


3565075


13%  Upregulatedd


Endoribonuclease dcr-1


dcr-1


176138


Downregulated


DAF-16/FOXO Controlled, germline Tumor affecting


dct-11


189237


10%  Downregulated


DAF-16/FOXO Controlled, germline Tumor affecting


dct-18


174934


8%  Downregulated


DeHydrogenases, Short chain


dhs-21


179741


Downregulated


DAF-12 Interacting Protein


din-1


174782


Downregulated


DIS3 (yeast disjunction abnormal) exonuclease homolog


dis-3


177875


11%  Downregulated


DAP (Death Associated Protein kinase) Like Kinase


dlk-1


173128


Downregulated


Mitochondrial import inner membrane translocase subunit TIM14


dnj-21


172231


10%  Downregulated


Protein DPY-27


dpy-27


175492


24%  Downregulated


DVE (Defective proVEntriculus in Drosophila) homolog


dve-1


180398


53%  Downregulated


Protein E01B7.1


E01B7.1


180175


Downregulated


Probable mitochondrial import inner membrane translocase subunit Tim17


E04A4.5


177242


8%  Downregulated


hypothetical protein


eak-7


3564920


30%  Upregulatedd


Elongation Factor


eef-2


172743


Upregulated and Downregulated


Protein EGL-27


egl-27


174121


18%  Upregulatedd


fatty acid ELOngation


elo-5


177320


45%  Downregulated


Enhanced RNAI (RNA interference)


eri-1


176868


43%  Downregulated


Protein ETS-9


ets-9


180702


23%  Downregulated


EXOnuclease


exo-3


173069


20%  Downregulated


Protein F33H2.8


F33H2.8


185238


36%  Downregulated


Protein F37C4.4


F37C4.4


177145


Downregulated


Mitochondrial import inner membrane translocase subunit tim-16


F45G2.8


176769


8%  Downregulated


F56H1.7


F56H1.7


6418597


25%  Downregulated


FATty acid desaturase


fat-7


179100


Downregulated


F-box A protein


fbxa-121


189476


Downregulated


Dimethylaniline monooxygenase [N-oxide-forming]


fmo-2


177958


20%  Upregulatedd


FRataxin (involved in human Friedrich’s ataxia) Homolog


frh-1


174002


Upregulated and Downregulated


Fourteen-Three-Three family


ftt-2


181348


Upregulated and Downregulated


General Anaesthetic Sensitivity abnormal


gas-1


181646


Downregulated


GDI (RabGDP Dissociation Inhibitor) family


gdi-1


178402


Downregulated


Protein GEI-4


gei-4


175195


27%  Downregulated


GaLactoFuranose synthesis (UGM, UDP-galactopyranose mutase)


glf-1


177358


49%  Downregulated


G protein,O, Alpha subunit


goa-1


172505


33%  Downregulated


G Protein, Alpha subunit


gpa-10


179075


10%  Downregulated


G Protein, Alpha subunit


gpa-11


173759


25%  Upregulatedd


G Protein, Alpha subunit


gpa-2


179219


Upregulated and Downregulated


G Protein, Alpha subunit


gpa-3


179319


15%  Downregulated


G Protein, Alpha subunit


gpa-9


191659

 

Abnormal growth rate


gro-1


175725


29%  Upregulatedd


G protein, Subunit Alpha


gsa-1


171687


84%  Downregulated


Glutathione S-Transferase


gst-10


178725


Upregulated and Downregulated


Glutathione S-Transferase


gst-5


187537


Downregulated


Spliceosome RNA helicase DDX39B homolog


hel-1


174333


9%  Downregulated


HIF (Hypoxia Inducible Factor) homologa


hif-1


180359


34%  Upregulatedd


High Incidence of Males (increased X chromosome loss)


him-6


178201


Downregulated


HIStone


his-71


181057


19%  Downregulated


Protein HLB-1


hlb-1


181499


Downregulated


Helix Loop Helix


hlh-30


177157


20%  Upregulatedd


Homeodomain interacting Protein Kinase


hpk-1


180695


37%  Downregulated


Protein HPO-31


hpo-31


3565786


52%  Downregulated


Heat shock transcription factor 1


hsf-1


173078


Upregulated and Downregulated


Heat Shock Protein


hsp-12.6


177778


16%  Downregulated


Heat Shock Protein


hsp-16.1


179286


Upregulated and Downregulated


Heat Shock Protein


hsp-16.48


179287


Upregulatedd


Heat Shock Protein


hsp-16.49


179288


Upregulated and Downregulated


Heat Shock Protein


hsp-4


174203


Downregulated


Heat shock 70kDa protein 9B (mortalin-2)


hsp-6


178873


Upregulated and Downregulated


Homolog of Yeast Longevity gene


hyl-1


177660


10%  Downregulated


INitiation Factor


inf-1


175966


Upregulated and Downregulated


INSulin related


ins-1


177936


25%  Upregulatedd


IRE1 kinase related


ire-1


174305


20%  Downregulated


Inositol Triphosphate Receptor


itr-1


177546


53%  Upregulatedd


JNK Kinase


jkk-1


180810


Downregulated


Jun N-terminal Kinase


jnk-1


177460


Upregulated and Downregulated


Protein K11D12.9


K11D12.9


178892


Downregulated


3-Ketoacyl-coA Thiolase


kat-1


174161


30%  Downregulated


Kruppel-Like Factor (zinc finger protein)


klf-1


175404


15%  Upregulatedd


hypothetical protein


klo-1


177557


15%  Downregulated


hypothetical protein


klo-2


184000


15%  Downregulated


human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog


kri-1


191275


Downregulated


LAG1 (yeast Longevity-Assurance Gene) Related


lagr-1


189370


10%  Downregulated


Lipid Binding Protein


lbp-4


179161


Downregulated


Lipid Binding Protein


lbp-6


172390


Upregulated and Downregulated


Lipid Binding Protein


lbp-8


188761


30%  Upregulatedd


Lipid Binding Protein


lbp-9


178686


Downregulated


LIM domain Binding Protein


ldb-1


181292


Downregulated


LEM domain protein


lem-2


175058


Downregulated


LEThal


let-23


174462


Upregulated and Downregulated


LEThal


let-502


172088


30%  Downregulated


LEThal


let-60


178104


Upregulatedd


LEThal


let-653


178120


13%  Downregulated


LEThal


let-765


175934


27%  Downregulated


LC3, GABARAP and GATE-16 family


lgg-1


174050


43%  Downregulated


Protein LIN-11


lin-11


172893


9%  Downregulated


Abnormal cell lineage


lin-15B


181662


42%  Downregulated


Abnormal cell LINeage


lin-2


181400


Upregulatedd


Abnormal cell lineage


lin-23


174058


Downregulated


Abnormal cell lineage


lin-3


178001


Downregulated


Abnormal cell lineage


lin-4


266860

 

Abnormal cell LINeage


lin-40


178788


Upregulated and Downregulated


hypothetical protein


lin-65


171739


24%  Downregulated


LIPase Like


lipl-4


179046


55%  Upregulatedd


nuclear LaMiN


lmn-1


172687


12%  Downregulated


Protein LPR-5


lpr-5


181297


16%  Downregulated


LSM Sm-like protein


lsm-7


177988


24%  Downregulated


LYSozyme


lys-8


173944


29%  Downregulated


Protein M05B5.2


M05B5.2


187451


45%  Downregulated


Protein M57.2


M57.2


177113


20%  Downregulated


Drosophila MAGonashi homolog


mag-1


173073


15%  Downregulated


Protein MBOA-1


mboa-1


181681


16%  Downregulated


yeast MCM (licensing factor) related


mcm-2


174841


Upregulated and Downregulated


Malate DeHydrogenase


mdh-2


175936


10%  Downregulated


Mediator of RNA polymerase II transcription subunit 15


mdt-15


175817


34%  Downregulated


Protein MDT-26


mdt-26


173960


Downregulated


MEChanosensory abnormality


mec-8


172771


Upregulatedd


Dual specificity mitogen-activated protein kinase kinase mek-2


mek-2


171872


10%  Downregulated


Mog interacting, Ectopic P granules


mep-1


178074


8%  Downregulated


Histone-lysine N-methyltransferase met-2


met-2


176183


23%  Downregulated


Abnormal methyl Viologen sensitivity


mev-1


260040


Downregulated


mir-124


mir-124


3565990


16%  Upregulatedd


mir-238


mir-238


3565806


19%  Downregulated


mir-246


mir-246


3565660


10%  Downregulated


mir-71


mir-71


260100


48%  Downregulated


Myc and Mondo-Like


mml-1


176050


10%  Downregulated


MAP kinase iNtegrating Kinase (MNK) homolog


mnk-1


174623


Downregulated


Modulation Of locomotion Defective


mod-5


171879


Downregulated


MAP Kinase


mpk-1


175545


16%  Downregulated


MTM (myotubularin) famil


mtm-3


175490


Downregulated


Y42G9A.4b


mvk-1


175863


14%  Downregulated


MaX-Like


mxl-2


175184


7%  Downregulated


Nuclear Cap-Binding Protein


ncbp-2


184953


24%  Downregulated


NFI (Nuclear Factor I) family


nfi-1


174225


Downregulated


Protein NHR-119


nhr-119


187340


10%  Downregulated


Protein NHR-25


nhr-25


181432


8%  Downregulated


Nuclear Hormone Receptor family


nhr-49


172839


56%  Downregulated


Protein NHR-77


nhr-77


191726


7%  Downregulated


Nuclear hormone receptor family member nhr-8


nhr-8


177551


35%  Downregulated


Neuropeptide-like protein genes family


nlp-7


184647


10%  Downregulated


Nicotinamide Nucleotide Transhydrogenase


nnt-1


180884


18%  Downregulated


Nuclear Pore complex Protein


npp-2


172611


11%  Downregulated


Nuclear Pore complex Protein


npp-3


174823


14%  Downregulated


Protein NSTP-3


nstp-3


191128


29%  Downregulated


NOT-Like (yeast CCR4/NOT complex component)


ntl-3


176614


Downregulated


NUclear localized Metal Responsive


numr-1


176048


Upregulatedd


NUclear localized Metal Responsive


numr-2


176049


Upregulatedd


Overexpression Longevity Determinant


old-1


191737


65%  Upregulatedd


Serine/threonine-protein kinase pak-1


pak-1


180873


50%  Upregulatedd


Abnormal embryonic PARtitioning of cytoplasm


par-5


178113


Upregulated and Downregulated


PArtner of DroSHa (DRSH-1 interactor)


pash-1


172950


31%  Downregulated


Paralysed Arrest at Two-fold


pat-10


172127


30%  Upregulatedd


Protein PAT-3


pat-3


175504


28%  Downregulated


Proteasome subunit beta type


pbs-5


173334


25%  Upregulatedd


Protein PCF-11


pcf-11


246008


19%  Downregulated


Putative pachytene checkpoint protein 2


pch-2


174313


22%  Upregulatedd


Protein Carboxymethyltransferase


pcm-1


178981


30%  Upregulatedd


Pyruvate Dehydrogenase Phosphatase homolog


pdp-1


172035


17%  Upregulatedd


defective PHArynx development


pha-4


180357


13%  Downregulated


mitochondrial ProHiBitin complex


phb-1


171768


Downregulated


mitochondrial ProHiBitin complex


phb-2


174034


Downregulated


Pyrazinamidase and NiCotinamidase


pnc-1


176833


Downregulated


PaNtothenate Kinase


pnk-1


172327


Downregulated


PeRoxireDoXin


prdx-2


266858


Downregulated


PeRoxireDoXin


prdx-3


175573


Downregulated


PaTched Related family


ptr-23


173362


13%  Downregulated


Protein R12B2.6


R12B2.6


187837


22%  Downregulated


RAB family


rab-5


172755


50%  Downregulated


RAB family


rab-7


174834


32%  Downregulated


RB (Retinoblastoma Binding protein) Related


rbr-2


177985


Upregulated and Downregulated


ReCQ DNA helicase family


rcq-5


175522


37%  Downregulated


RHo GDI


rhi-1


180721


Downregulated


hypothetical protein


rict-1


3565035


10%  Upregulatedd


Protein RPN-11


rpn-11


173744


19%  Downregulated


Protein RPN-6.1


rpn-6.1


175972


Downregulated


Protein RPT-1


rpt-1


179641


28%  Downregulated


SR protein related


rsr-2


174862


Downregulated


Protein SAC-1


sac-1


172778


25%  Downregulated


Shwachman-Bodian-Diamond Syndrome protein homolog


sbds-1


175218


Downregulated


Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog


sbt-1


180366


Downregulated


Suppressor of Constitutive Dauer formation


scd-2


179054


Downregulated


SCP-Like extracellular protein


scl-1


186053


Downregulated


SCP-Like extracellular protein


scl-20


191309


18%  Downregulated


SERotonin/octopamine receptor family


ser-4


175322


Downregulated


Sestrin homolog


sesn-1


171593


Upregulated and Downregulated


SET (trithorax/polycomb) domain containing


set-6


181371


10%  Downregulated


Src Homology domain C-terminal, adaptor homolog


shc-1


3565745


38%  Downregulated


Stress-induced protein 1


sip-1


176471


18%  Downregulated


Yeast SIR related (68.8 kD) (sir-2.1)


sir-2.1


177924


Upregulated and Downregulated


SKiNhead


skn-1


177343


Upregulated and Downregulated


SKp1 Related (ubiquitin ligase complex component)


skr-1


172775


Downregulated


SKp1 Related (ubiquitin ligase complex component)


skr-2


172773


Downregulated


suppressor of MEK null


smk-1


179243


21%  Downregulated


SMN (human Survival Motor Neuron gene) homolog


smn-1


172783


26%  Downregulated


Protein SNAP-1


snap-1


179193


40%  Downregulated


Protein SNAP-29


snap-29


176233


49%  Downregulated


synuclein, alpha (non A4 component of amyloid precursor)


SNCA

 

25%  Upregulated >


Superoxide dismutase (24.5 kD) (sod-2)


sod-2


172632


44%  Upregulatedd


Sphingosine Phosphate Lyase


spl-1


176857


22%  Downregulated


Specificity Protein) Transcription Factor


sptf-3


189783


24%  Downregulated


SYnapse Defective


syd-2


181255


Downregulated


Protein T19B10.2


T19B10.2


179551


34%  Downregulated


Protein T27F7.1


T27F7.1


173863


34%  Downregulated


TBC (Tre-2/Bub2/Cdc16) domain family


tbc-7


180784


Downregulated


TATA-Binding Protein


tbp-1


176054


21%  Downregulated


TransCription Elongation Regulator homolog


tcer-1


174150


15%  Upregulatedd


Translocase, Inner Mitochondrial Membrane


timm-23


173041


7%  Downregulated


Probable mitochondrial import inner membrane translocase subunit tim-44


tin-44


172302


11%  Downregulated


TBP-Like Factor


tlf-1


172676


33%  Downregulated


K02G10.3


tmem-135


180740


Downregulated


TOMosyn synaptic protein


tom-1


172209


33%  Downregulated


Translocase of Outer Mitochondrial Membrane


tomm-22


173436


14%  Downregulated


TOPoisomerase


top-1


266847


19%  Downregulated


Protein TRPA-1


trpa-1


178118


34%  Upregulatedd


ThioRedoXin


trx-1


181863


Downregulated


Protein TTX-1


ttx-1


180313


25%  Downregulated


Abnormal thermotaxis


ttx-3


181357


10%  Downregulated


UBiquitin Conjugating enzyme


ubc-13


177073


Downregulated


UBiquitin C-terminal Hydrolase (family 1)


ubh-1


179039


Downregulated


UBiquitin C-terminal Hydrolase (family 1)


ubh-3


259626


Downregulated


Ubiquitin Fusion Degradation (yeast UFD homolog)


ufd-1


3565860


64%  Downregulated


Ubiquitin-Like Protease


ulp-1


175704


22%  Downregulated


UNCoordinated


unc-4


174544


100%  Upregulatedd


UNCoordinated


unc-51


180311


Upregulated and Downregulated


UNCoordinated


unc-60


178640


Downregulated


UNCoordinated


unc-64


176743


Upregulatedd


UNCoordinated


unc-76


180014


50%  Upregulatedd


Protein USP-48


usp-48


172782


Downregulated


Variable ABnormal morphology


vab-1


173794


20%  Upregulatedd


related to yeast Vacuolar Protein Sorting factor


vps-16


175913


21%  Downregulated


Protein VPS-20


vps-20


171654


Downregulated


Protein VPS-22


vps-22


175672


43%  Downregulated


Vacuolar sorting protein


vps-33.1


176221


15%  Downregulated


VPS-36


vps-36


179520


27%  Downregulated


related to yeast Vacuolar Protein Sorting factor


vps-37


178944


44%  Downregulated


Vaccinia Related Kinase


vrk-1


174004


36%  Downregulated


Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment


wip-1


175681


Downregulated


WW domain Protein (E3 ubiquitin ligase)


wwp-1


171647


Upregulated and Downregulated


Protein XBP-1


xbp-1


175541

 

Y46G5A.6 pseudogene


Y46G5A.6


189958


Downregulated


hypothetical protein


Y47D3A.29


176544


22%  Downregulated


Protein Y55F3AM.3


Y55F3AM.3


176922


9%  Downregulated


Y77E11A.7b


Y77E11A.7


176951


24%  Downregulated


Co-chaperone protein daf-41


ZC395.10


175727

 

Protein ZFH-2


zfh-2


171670


45%  Downregulated


Zinc Finger Protein


zfp-1


176237


Downregulated


Zinc finger Transcription Factor family


ztf-12


179257


Downregulated

Reference: HAGR
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