Pro-longevity genes in Caenorhabditis Elegans

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Name


Symbol


Entrez ID


Max average lifespan change


CG4006 gene product from transcript CG4006-RA


Akt1


41957


11%  Downregulated


Autophagy-specific gene 1


Atg1


39454


25%  Upregulatedd


Autophagy-specific gene 2


Atg2


38344


28%  Upregulatedd


Autophagy-specific gene 7


Atg7


37141


Downregulated


Autophagy-related 8a


Atg8a


32001


Upregulated and Downregulated


Aut1 -CG6877 gene product from transcript CG6877-RA


Aut1


40044


28%  Downregulated


Bag of marbles


bam


43038


50%  Upregulatedd


Blue cheese


bchs


33819


45%  Downregulated


Basket


bsk


44801


16%  Downregulated


Carnation


car


32947


Upregulatedd


Catalase


Cat


40048


33%  Upregulatedd


Cystathionine beta-synthase


Cbs


33081


43%  Upregulatedd


CTP:phosphocholine cytidylyltransferase 1


Cct1


117353


8%  Upregulatedd


Cyclin-dependent kinase 5


Cdk5


36727


33%  Downregulated


Ceramide transfer protein


cert


38928


Downregulated


CG11165


CG11165


35751


54%  Upregulatedd


CG13890


CG13890


38100


31%  Upregulatedd


CG14207-PA


CG14207


32955


5%  Upregulatedd


Juvenile hormone esterase binding protein 29 (DmP29)


CG3776


37996


39%  Downregulated


CG9940


CG9940


32328


Upregulatedd


Cheerio


cher


42066


9%  Upregulatedd


Carmine


cm


31647


Downregulated


DJ-1alpha


DJ-1alpha


36543


Downregulated


dj-1beta


dj-1beta


43652


Downregulated


Daxx-like protein


DLP


33906


20%  Downregulated


deep orange


dor


31118


Downregulated


decapentaplegic


dpp


33432


29%  Downregulated


Dynamin related protein 1


Drp1


33445


21%  Upregulatedd


Dystrophin


Dys


42327


Downregulated


Elongation factor 148D


Ef1alpha48D


36271


41%  Upregulatedd


Ecdysone-induced protein 28/29kD


Eip71CD


39675


70%  Upregulatedd


embryonic lethal abnormal vision


elav


31000


66%  Downregulated


fatty acid bindin protein


fabp


3772232


81%  Upregulatedd


frataxin homolog


fh


31845


35%  Upregulatedd


fork head


fkh


43383


14%  Upregulatedd


Forkhead box, sub-group O


foxo


41709


33%  Upregulatedd


four wheel drive


fwd


45374


9%  Upregulatedd


garnet


g


44819


Downregulated


CG11086 gene product from transcript CG11086-RA


Gadd45


35646


77%  Upregulatedd


Glutamate-cysteine ligase catalytic subunit


Gclc


53581


50%  Upregulatedd


Glutamate-cysteine ligase modifier subunit


Gclm


248194


24%  Upregulatedd


gigas


gig


40201


Upregulatedd


Glial Lazarillo


GLaz


36447


Upregulated and Downregulated


Glycine N-methyltransferase


Gnmt


41561


Upregulatedd


Glutathione S transferase S1


GstS1


36927


33%  Upregulatedd


hebe gene product from transcript hebe-RD


hebe


36011


24%  Upregulatedd


hook


hk


35169


Downregulated


hopscotch


hop


32080


Upregulated and Downregulated


Heat shock protein cognate 3


Hsc70-3


32133


27%  Upregulatedd


Heat shock protein 22


Hsp22


3772576


Upregulated and Downregulated


Heat shock protein 26


Hsp26


39075


30%  Upregulatedd


Heat shock protein 27


Hsp27


39078


30%  Upregulatedd


Heat shock gene 67Bc


Hsp67Bc


39071


6%  Upregulatedd


Heat shock protein 68


Hsp68


42852


20%  Upregulatedd


Heat Shock Protein


hsp70

 

Upregulatedd


Heat shock 70kDa protein 1A


Hsp70Ba


44921


Upregulated and Downregulated


Insulin-like peptide 6


Ilp6


31220


16%  Upregulatedd


Ecdysone-inducible gene L2


ImpL2


38513


23%  Upregulatedd


inactivation no afterpotential E


inaE


32343


73%  Upregulatedd


Inositol-requiring enzyme-1


Ire1


42358


Downregulated


Thioredoxin peroxidase 1


Jafrac1


53578


29%  Upregulatedd


CG11546


kermit


46027


30%  Downregulated


let-7


let-7


12798012

 

light


lt


3355130


Downregulated


Mothers against dpp


Mad


33529


22%  Downregulated


magu gene product from transcript magu -RD


magu


36048


5%  Upregulatedd


Malic enzyme


Men


47173


45%  Upregulatedd


mir-125 stem loop


mir-125


12798013


Downregulated


mir-14 stem loop


mir-14


12798384


Downregulated


mir-34 stem loop


mir-34


12798087


Downregulated


Maleless


mle


35523


48%  Downregulated


Muscle LIM protein at 84B


Mlp84B


40849


35%  Downregulated


CG13316-PC, isoform C


Mnt


31331


Upregulated and Downregulated


CG5475-PA


Mpk2


42866


40%  Downregulated


Multidrug resistance protein 4 ortholog


Mrp4


41387


Upregulated and Downregulated


DNA methyltransferase 2


Mt2


34632


Upregulatedd


Metal response element-binding Transcription Factor-1


MTF-1


39089


40%  Upregulatedd


methuselah


mth


38058


35%  Upregulatedd


myoglianin


myo


43811


25%  Upregulatedd


Naam gene product from transcript Naam-RA


Naam


42348


30%  Upregulatedd


Neurofibromin 1


Nf1


43149


68%  Upregulatedd


Neural Lazarillo


NLaz


33324


31%  Downregulated


NAD-dependent methylenetetrahydrofolate dehydrogenase


Nmdmc


47895


120%  Upregulatedd


ornithine carbamoyltransferase


OTC


5009


21%  Upregulatedd


CG7393-PA


p38b


34780


60%  Downregulated


parkin


park


40336


28%  Upregulatedd


Protein-L-isoaspartate (D-aspartate) O-methyltransferase


Pcmt


40668


39%  Upregulatedd


peroxin 16


Pex16


40293


75%  Downregulated


Phosphoglycerate mutase 5


Pgam5


31143


9%  Downregulated


CG4141 gene product from transcript CG4141-RA


Pi3K92E


42446


5%  Downregulated


PTEN-induced putative kinase 1


Pink1


31607


18%  Upregulatedd


cAMP-dependent protein kinase 1


Pka-C1


34284


Upregulatedd


Plenty of SH3s


POSH


36990


14%  Upregulatedd


Pre-RNA processing factor 19


Prp19


37123


25%  Upregulatedd


Peroxiredoxin 5


Prx5


3771951


30%  Upregulatedd


CG5671 gene product from transcript CG5671-RB


Pten


43991


13%  Upregulatedd


ruby


rb


31381


Downregulated


RNA-binding protein 9


Rbp9


33498


33%  Downregulated


CG14975-PA


Rdh


2769007


8%  Upregulatedd


rhomboid-7


rho-7


36281


Downregulated


rutabaga


rut


32406


Downregulated


rosy


ry


41605


Downregulated


Sarcoglycan delta


Scgdelta


31129


30%  Downregulated


Succinate dehydrogenase B


SdhB


35590


66%  Downregulated


succinate dehydrogenase, cytochrome b556 subunit


SdhC


41340


22%  Downregulated


CG5216-PA


Sir2


34708


Upregulated and Downregulated


CG5085-PA


Sirt2


42414


20%  Downregulated


Sirtuin 4


Sirt4


31480


20%  Upregulatedd


CG6284-PB


Sirt6


41254


20%  Downregulated


SNF1A/AMP-activated protein kinase


SNF1A


43904


20%  Upregulatedd


SNF4/AMP-activated protein kinase gamma subunit


SNF4Agamma


42515


23%  Downregulated


Superoxide dismutase


Sod


39251


Upregulated and Downregulated


Superoxide dismutase 2 (Mn)


Sod2


36878


Upregulated and Downregulated


Spargel


Spargel


40562


33%  Upregulatedd


Signal-transducer and activator of transcription protein at 92E


Stat92E


42428


33%  Downregulated


Suppressor of variegation 205


Su(var)205


34119


Upregulated and Downregulated


sugarbabe


sug


36424


9%  Upregulatedd


telomerase reverse transcriptase


tert


796551


60%  Downregulated


CG8846 gene product from transcript CG8846-RA


Thor


33569


22%  Upregulatedd


takeout


to


43036


26%  Upregulatedd


Topoisomerase 3alpha


Top3alpha


35236


20%  Downregulated


thioredoxin-2


Trx-2


34281


Downregulated


Thioredoxin reductase-1


Trxr-1


31760


Upregulatedd


Thioredoxin T


TrxT


31443


15%  Upregulatedd


CG6147-PA Tuberous sclerosis complex genes 1


Tsc1


42862


Upregulatedd


uncoupling protein 2 (mitochondrial, proton carrier)


UCP2


7351


30%  Upregulatedd


Vacuolar H+-ATPase SFD subunit


VhaSFD


34997


10%  Upregulatedd


Vinculin


Vinc


31201


150%  Upregulatedd


CG1973 gene product from transcript CG1973-RA


yata


43508


Downregulated


Zwischenferment


Zw


32974


38%  Upregulatedd

Reference: HAGR
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