Pro-longevity genes in Caenorhabditis Elegans

Name

Symbol

Entrez ID

Max average lifespan change

CG4006 gene product from transcript CG4006-RA

Akt1

41957

11%  Downregulated

Autophagy-specific gene 1

Atg1

39454

25%  Upregulatedd

Autophagy-specific gene 2

Atg2

38344

28%  Upregulatedd

Autophagy-specific gene 7

Atg7

37141

Downregulated

Autophagy-related 8a

Atg8a

32001

Upregulated and Downregulated

Aut1 -CG6877 gene product from transcript CG6877-RA

Aut1

40044

28%  Downregulated

Bag of marbles

bam

43038

50%  Upregulatedd

Blue cheese

bchs

33819

45%  Downregulated

Basket

bsk

44801

16%  Downregulated

Carnation

car

32947

Upregulatedd

Catalase

Cat

40048

33%  Upregulatedd

Cystathionine beta-synthase

Cbs

33081

43%  Upregulatedd

CTP:phosphocholine cytidylyltransferase 1

Cct1

117353

8%  Upregulatedd

Cyclin-dependent kinase 5

Cdk5

36727

33%  Downregulated

Ceramide transfer protein

cert

38928

Downregulated

CG11165

CG11165

35751

54%  Upregulatedd

CG13890

CG13890

38100

31%  Upregulatedd

CG14207-PA

CG14207

32955

5%  Upregulatedd

Juvenile hormone esterase binding protein 29 (DmP29)

CG3776

37996

39%  Downregulated

CG9940

CG9940

32328

Upregulatedd

Cheerio

cher

42066

9%  Upregulatedd

Carmine

cm

31647

Downregulated

DJ-1alpha

DJ-1alpha

36543

Downregulated

dj-1beta

dj-1beta

43652

Downregulated

Daxx-like protein

DLP

33906

20%  Downregulated

deep orange

dor

31118

Downregulated

decapentaplegic

dpp

33432

29%  Downregulated

Dynamin related protein 1

Drp1

33445

21%  Upregulatedd

Dystrophin

Dys

42327

Downregulated

Elongation factor 148D

Ef1alpha48D

36271

41%  Upregulatedd

Ecdysone-induced protein 28/29kD

Eip71CD

39675

70%  Upregulatedd

embryonic lethal abnormal vision

elav

31000

66%  Downregulated

fatty acid bindin protein

fabp

3772232

81%  Upregulatedd

frataxin homolog

fh

31845

35%  Upregulatedd

fork head

fkh

43383

14%  Upregulatedd

Forkhead box, sub-group O

foxo

41709

33%  Upregulatedd

four wheel drive

fwd

45374

9%  Upregulatedd

garnet

g

44819

Downregulated

CG11086 gene product from transcript CG11086-RA

Gadd45

35646

77%  Upregulatedd

Glutamate-cysteine ligase catalytic subunit

Gclc

53581

50%  Upregulatedd

Glutamate-cysteine ligase modifier subunit

Gclm

248194

24%  Upregulatedd

gigas

gig

40201

Upregulatedd

Glial Lazarillo

GLaz

36447

Upregulated and Downregulated

Glycine N-methyltransferase

Gnmt

41561

Upregulatedd

Glutathione S transferase S1

GstS1

36927

33%  Upregulatedd

hebe gene product from transcript hebe-RD

hebe

36011

24%  Upregulatedd

hook

hk

35169

Downregulated

hopscotch

hop

32080

Upregulated and Downregulated

Heat shock protein cognate 3

Hsc70-3

32133

27%  Upregulatedd

Heat shock protein 22

Hsp22

3772576

Upregulated and Downregulated

Heat shock protein 26

Hsp26

39075

30%  Upregulatedd

Heat shock protein 27

Hsp27

39078

30%  Upregulatedd

Heat shock gene 67Bc

Hsp67Bc

39071

6%  Upregulatedd

Heat shock protein 68

Hsp68

42852

20%  Upregulatedd

Heat Shock Protein

hsp70

 

Upregulatedd

Heat shock 70kDa protein 1A

Hsp70Ba

44921

Upregulated and Downregulated

Insulin-like peptide 6

Ilp6

31220

16%  Upregulatedd

Ecdysone-inducible gene L2

ImpL2

38513

23%  Upregulatedd

inactivation no afterpotential E

inaE

32343

73%  Upregulatedd

Inositol-requiring enzyme-1

Ire1

42358

Downregulated

Thioredoxin peroxidase 1

Jafrac1

53578

29%  Upregulatedd

CG11546

kermit

46027

30%  Downregulated

let-7

let-7

12798012

 

light

lt

3355130

Downregulated

Mothers against dpp

Mad

33529

22%  Downregulated

magu gene product from transcript magu -RD

magu

36048

5%  Upregulatedd

Malic enzyme

Men

47173

45%  Upregulatedd

mir-125 stem loop

mir-125

12798013

Downregulated

mir-14 stem loop

mir-14

12798384

Downregulated

mir-34 stem loop

mir-34

12798087

Downregulated

Maleless

mle

35523

48%  Downregulated

Muscle LIM protein at 84B

Mlp84B

40849

35%  Downregulated

CG13316-PC, isoform C

Mnt

31331

Upregulated and Downregulated

CG5475-PA

Mpk2

42866

40%  Downregulated

Multidrug resistance protein 4 ortholog

Mrp4

41387

Upregulated and Downregulated

DNA methyltransferase 2

Mt2

34632

Upregulatedd

Metal response element-binding Transcription Factor-1

MTF-1

39089

40%  Upregulatedd

methuselah

mth

38058

35%  Upregulatedd

myoglianin

myo

43811

25%  Upregulatedd

Naam gene product from transcript Naam-RA

Naam

42348

30%  Upregulatedd

Neurofibromin 1

Nf1

43149

68%  Upregulatedd

Neural Lazarillo

NLaz

33324

31%  Downregulated

NAD-dependent methylenetetrahydrofolate dehydrogenase

Nmdmc

47895

120%  Upregulatedd

ornithine carbamoyltransferase

OTC

5009

21%  Upregulatedd

CG7393-PA

p38b

34780

60%  Downregulated

parkin

park

40336

28%  Upregulatedd

Protein-L-isoaspartate (D-aspartate) O-methyltransferase

Pcmt

40668

39%  Upregulatedd

peroxin 16

Pex16

40293

75%  Downregulated

Phosphoglycerate mutase 5

Pgam5

31143

9%  Downregulated

CG4141 gene product from transcript CG4141-RA

Pi3K92E

42446

5%  Downregulated

PTEN-induced putative kinase 1

Pink1

31607

18%  Upregulatedd

cAMP-dependent protein kinase 1

Pka-C1

34284

Upregulatedd

Plenty of SH3s

POSH

36990

14%  Upregulatedd

Pre-RNA processing factor 19

Prp19

37123

25%  Upregulatedd

Peroxiredoxin 5

Prx5

3771951

30%  Upregulatedd

CG5671 gene product from transcript CG5671-RB

Pten

43991

13%  Upregulatedd

ruby

rb

31381

Downregulated

RNA-binding protein 9

Rbp9

33498

33%  Downregulated

CG14975-PA

Rdh

2769007

8%  Upregulatedd

rhomboid-7

rho-7

36281

Downregulated

rutabaga

rut

32406

Downregulated

rosy

ry

41605

Downregulated

Sarcoglycan delta

Scgdelta

31129

30%  Downregulated

Succinate dehydrogenase B

SdhB

35590

66%  Downregulated

succinate dehydrogenase, cytochrome b556 subunit

SdhC

41340

22%  Downregulated

CG5216-PA

Sir2

34708

Upregulated and Downregulated

CG5085-PA

Sirt2

42414

20%  Downregulated

Sirtuin 4

Sirt4

31480

20%  Upregulatedd

CG6284-PB

Sirt6

41254

20%  Downregulated

SNF1A/AMP-activated protein kinase

SNF1A

43904

20%  Upregulatedd

SNF4/AMP-activated protein kinase gamma subunit

SNF4Agamma

42515

23%  Downregulated

Superoxide dismutase

Sod

39251

Upregulated and Downregulated

Superoxide dismutase 2 (Mn)

Sod2

36878

Upregulated and Downregulated

Spargel

Spargel

40562

33%  Upregulatedd

Signal-transducer and activator of transcription protein at 92E

Stat92E

42428

33%  Downregulated

Suppressor of variegation 205

Su(var)205

34119

Upregulated and Downregulated

sugarbabe

sug

36424

9%  Upregulatedd

telomerase reverse transcriptase

tert

796551

60%  Downregulated

CG8846 gene product from transcript CG8846-RA

Thor

33569

22%  Upregulatedd

takeout

to

43036

26%  Upregulatedd

Topoisomerase 3alpha

Top3alpha

35236

20%  Downregulated

thioredoxin-2

Trx-2

34281

Downregulated

Thioredoxin reductase-1

Trxr-1

31760

Upregulatedd

Thioredoxin T

TrxT

31443

15%  Upregulatedd

CG6147-PA Tuberous sclerosis complex genes 1

Tsc1

42862

Upregulatedd

uncoupling protein 2 (mitochondrial, proton carrier)

UCP2

7351

30%  Upregulatedd

Vacuolar H+-ATPase SFD subunit

VhaSFD

34997

10%  Upregulatedd

Vinculin

Vinc

31201

150%  Upregulatedd

CG1973 gene product from transcript CG1973-RA

yata

43508

Downregulated

Zwischenferment

Zw

32974

38%  Upregulatedd

Reference: HAGR