Life extension by compounds in Rattus Norvegicus

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Name of
Formulation

Dose

Avg/Med Lifespan Change (%) -96267.9

Max Lifespan Change (%) -94.993

Strain

Significance
(Yes: Y, No: N)

Reference

C60

1.7 mg/kg
of body weight

90


Y

22498298

Dimethylaminoethyl
p-chlorophenoxyacetate

0.3g/L

27.3

39.7

Swiss

Y

4147092

Polypeptide
Pineal extract

0.5 mg, 5
times a week

25


Y

575333

Epithalamin

NA

25


Y

9701766

Enalapril

10
mg/kg/day

21.36


Wistar

Y

17557916

Losartan

30
mg/kg/day

19.32


Wistar

Y

17557916

Olive Oil


18


Y

22498298

Ginkgo
biloba extract

50 mg/kg

17.4


Fischer
344

Y

9469738

L-deprenyl

0.0025

16.7

17

Fischer
344

Y

2118586

Thyroxin

1 µg/g
bodyweight

16.1


Wistar

ND

6632988

L-deprenyl

0.5 mg/kg.
3 times a week

15.1


F344/DuCrj

Y

8423709

Epigallocatechin-3-gallate

25 mg per
kg per day

13


Wistar

Y

23834676

Thyroxin

2 µg/g
bodyweight

11.6


Wistar

ND

6632988

Thyroxin

2 µg/g
bodyweight

11.1


Wistar

ND

6632988

Marine
collagen peptides

0.09

11

13

Sprague-Dawley

Y

20553190

Acticoa
powder

24 mg/5
ml/kg

11


Wistar-Unilever

Y

18179729

Sodim
cyclamate

0.43/100 g

9.77

-11.28

Wistar

Y

5132583

Thyroxin

1 µg/g
bodyweight

8.4


Wistar

ND

6632988

L-deprenyl

0.25
mg/kg. 3 times a week

8.1


F344/DuCrj

Y

16463106

Buformin

5 mg/day

7

5.5

LIO

Y

14618027

Thyroxin

0.5 µg/g
bodyweight

6.9


Wistar

ND

6632988

L-deprenyl

0.25
mg/kg. 3 times a week

6.7


F344/DuCrj

Y

16463106

L-deprenyl

0.5 mg/kg.
3 times a week

5.6

1

F344/DuCrj

Y

8030852

Metformin

300
mg/kg/day

2.3

2.1

Fischer
344

N

20304770

L-Glu-L-Trp
dipeptide

5 µg/rat.
5 times a week

0

10.4


ND

11707921

Alpha-lipoic
acid

1.5 g/kg

0


BN/SsNOlaHSD

N

18486188

Thyroxin

0.5 µg/g
bodyweight

-3.5


Wistar

ND

6632988

Disulfiram

1 in 2000

-5.08


Wistar

N

5469789

Disulfiram

1 in 1000

-21.18


Wistar

Y

5469789

Reference: HAGR
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