Life extension by compounds in other species

[raw]


Name of
Formulation

Dose

>Avg/Med Lifespan Change (%) -96267.9

>Max Lifespan Change (%) -94.993

Strain

Significance
(Yes: Y, No: N)

Reference

Indolepropionamide

30 µM

>267.9


odiosa

Y

20421998

Indolepropionamide

20 µM

>229.7


odiosa

Y

20421998

Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate

1.25 µM

>157.3


Y

25190068

Indolepropionamide

10 µM

>137.8


odiosa

Y

20421998

Aspirin

5.65×10^5
g aspirin/g food

>134


Y

25833406

Aspirin

2.263×10^4
g aspirin/g food

>111


Y

25833406

SkQ1

0.55 nM

>100


Y

19120018

Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate

2.5 µM

>98.6


Y

25190068

Kinetin

25 ppm

>80

>19.7


Y

7488181

Metformin

1.78×10^3
g metformin/g diet

>79


Y

25833406

Aspirin

2.263×10^4
g aspirin/g food

>77


Y

25833406

EGTA

0.25% on
alternate days

>75.9


ND

804507

Aspirin

5.65×10^5
g aspirin/g food

>67


Y

25833406

Nordihydroguaiaretic
acid

0.005%
(w/v)

>64.3


Y

3749035

Resveratrol

600 µg/g
food

>56

>59

Gonarezhou

Y

16461283

Aspirin

5.65×10^5
g aspirin/g food

>52


Y

25833406

Citrate

0.25% on
alternate days

>51.7


ND

804507

Glycerol

274 mM

>51


Y

24835191

SkQ1

100 nM

>50


Y

19120018

Edetate
Calcium Disodium

0.25% on
alternate days

>49.4


ND

804507

Aspirin

2.263×10^4
g aspirin/g food

>49


Y

25833406

EUK-134

3.1 µM

>48.8


Y

25190068

Tartrate

0.25% on
alternate days

>43.7


ND

804507

Oregano and
Cranberry extracts

0.02

>43


Loew

Y

21455602

Resveratrol

12 µg

>42.9

>17


Y

23220248

Nordihydroguaiaretic
acid

0.001%
(w/v)

>42.7


Y

3749035

Metformin

1.78×10^3
g metformin/g diet

>39


Y

25833406

Resveratrol

30 µM

>38


Y

22868943

Curare

0.00%

>34


Y

3833547

N-Acetyl
Cysteine

10 nM

>32.4

>8.6


Y

30243020

Curare

0.00%

>32


Y

3833547

N-Acetyl
Cysteine

100 nM

>31

>8.69


Y

30243020

N-Acetyl
Cysteine

1 µM

>31

>7.6


Y

30243020

N-Acetyl
Cysteine

100 µM

>31

>7.6


Y

30243020

N-Acetyl
Cysteine

1 mM

>31

>2.9


Y

30243020

N-Acetyl
Cysteine

10 µM

>29.6

>7.6


Y

30243020

Sodium
hypophosphite

1 mM

>28.5

>34.3


Y

3721207

Sodium
hypophosphite

1 mM

>28.1

>27


Y

3721207

Butylated
hydroxyanisole

10 mM

>27

>17.6


Y

9207858

EUK-134

1.6 µM

>26.4


Y

25190068

Butylated
hydroxytoluene

1000 µM

>26.1


Y

6656301

Curare

0.00%

>26


Y

3833547

N-Acetyl
Cysteine

100 µM

>26

>9.8


Y

30243020

Sodium
hypophosphite

5 mM

>25.4

>19.7


Y

3721207

Sodium
hypophosphite

100 µM

>24.9

>22.9


Y

3721207

Vitamin E

3 mM

>24.5


clone 4B61

Y

15374519

N-Acetyl
Cysteine

1 mM

>24

>8.8


Y

30243020

Sodium
hypophosphite

5 mM

>23.6

>21.9


Y

3721207

Resveratrol

100 µL

>23

>32

TZ 97-2

Y

22960591

Kinetin

125 ppm

>22.9

>15.8


Y

7488181

Melatonin

10 mg/L

>22.8

>20.9


Y

9406982

N-Acetyl
Cysteine

10 µM

>22.7

>6.9


Y

30243020

N-Acetyl
Cysteine

10 nM

>22.6

>6.9


Y

30243020

Vitamin E

25 µg/mL

>21


Y

6479253

Cortisone

100 µM

>20.8

>0

clone 4B61

Y

2782995

Melatonin

10 mg/L

>20.8

>14.8


Y

9406982

Butylated
hydroxyanisole

25 mM

>20.5

>2.2


Y

9207858

EUK-134

12.5 µM

>20.2


Y

25190068

Cortisone

200 µM

>19.3

>0

clone 4B61

Y

2782995

Butylated
hydroxytoluene

1000 µM

>19


Y

6656301

Resveratrol

200 µg/g

>19


TZ 97-2

Y

25569124

N-Acetyl
Cysteine

100 nM

>18.7

>4.9


Y

30243020

Butylated
hydroxyanisole

5 mM

>18.4

>6.6


Y

9207858

Sodium
hypophosphite

100 µM

>18

>21


Y

3721207

Vitamin E

3 mM

>16.4

>6.7

clone 4B61

Y

15374519

3,3′-thiodipropionic
acid

2 mM

>16.4


clone 4B61

Y

15374519

N-Acetyl
Cysteine

100 µM

>16

>13.9


Y

30243020

N-Acetyl
Cysteine

1 mM

>16

>13.9


Y

30243020

N-Acetyl
Cysteine

1 µM

>16

>11.1


Y

30243020

N-Acetyl
Cysteine

10 µM

>16

>0


Y

30243020

N-Acetyl
Cysteine

1 µM

>16

>6.9


Y

30243020

Resveratrol

100 µM

>15.6

>22.5


Y

19264118

Butylated
hydroxyanisole

10 mM

>15.1

>27


Y

9207858

Propyl
gallate

25 µg/ml

>15.1

>12.2


Y

8950031

Butylated
hydroxytoluene

100 µM

>14.3


Y

6656301

Kinetin

25 ppm

>14.2

>12.9


Y

7488181

Acanthophora
spicifera extract

5 µg/ml

>14


Y

24120568

Resveratrol

200 µg/g

>14


TZ 97-2

Y

25569124

Naproxen

1 µM

>13.93

>5.56


Y

27484416

Nordihydroguaiaretic
acid

0.01%
(w/v)

>13.6


N

3749035

Sodium
hypophosphite

10 µM

>13.2

>12.4


Y

3721207

Butylated
hydroxyanisole

25 mM

>13.1

>4.4


Y

9207858

Sodium
hypophosphite

10 µM

>13

>13.3


Y

3721207

Butylated
hydroxytoluene

100 µM

>13


Y

6656301

Resveratrol

100 µL

>13

>23

TZ 97-2

Y

22960591

Ascorbic
acid

50 mg/L

>12.1

>6.7


ND

9406982

N-Acetyl
Cysteine

100 nM

>12

>8.3


Y

30243020

Nordihydroguaiaretic
acid

0.001%
(w/v)

>11.9


N

3749035

Vitamin E

25 mg/L

>11.7

>17.1


ND

9406982

Resveratrol

100 µM

>11.2

>-1.4


N

19264118

Melatonin

10 mg/L

>10.8

>5.1


ND

9406982

3,3′-thiodipropionic
acid

2 mM

>10

>0

clone 4B61

Y

15374519

Vitamin E

concentration
of 10^ -4

>9.2

>0


N

7428854

Jania
acutilobum extract

5 µg/ml

>9.1


Y

24120568

Hydralazine

1 µM

>9.01

>0


Y

27484416

Propyl
gallate

25 µg/ml

>8.7

>15.3


Y

8950031

Recombinant
GDF11

0.2 mg/kg

>8.51

>7.69


Y

30519861

Peyssonnelia
sp. extract

2 µg/ml

>8.5


Y

24120568

Rotenone

15 pM

>8.1


MZM-0410

Y

27135165

Resveratrol

100 µM

>8

>36.3


N

19264118

N-Acetyl
Cysteine

10 nM

>8

>19.4


Y

30243020

Butylated
hydroxyanisole

5 mM

>7.9

>6.9


Y

9207858

Nordihydroguaiaretic
acid

0.005%
(w/v)

>6.7


N

3749035

Resveratrol

100 µM

>6.2

>7.3


N

19264118

Sodium
hypophosphite

1 µM

>5.3

>5.7


Y

3721207

N-Acetyl
Cysteine

10 nM

>5.1

>0


Y

30243020

N-Acetyl
Cysteine

100 nM

>5.1

>-2


Y

30243020

Butylated
hydroxytoluene

10 µM

>4.8


Y

6656301

Butylated
hydroxytoluene

10 µM

>4.3


Y

6656301

Butylated
hydroxyanisole

1 mM

>4

>1.3


N

9207858

Resveratrol

100 µM

>3.8

>5.7


N

19264118

Rhodiola
rosea


>2.7

>2.7

N4

Y

26497336

Resveratrol

100 µM

>2.6

>17.5


N

19264118

Resveratrol

100 µM

>2.6

>13.9


N

19264118

Resveratrol

100 µM

>2.5

>-7.7


N

19264118

Resveratrol

100 µM

>2.3

>5


N

19264118

Cortisone

50 µM

>2.2

>0

clone 4B61

N

2782995

Butylated
hydroxyanisole

1 mM

>1.7

>0.8


N

9207858

Resveratrol

100 µM

>1.5

>10


N

19264118

Rhodiola
rosea


>1.5

>1.6

N4

Y

26497336

Resveratrol

100 µM

>1.3

>16.6


N

19264118

Sodium
hypophosphite

1 µM

>1

>6


Y

3721207

Cortisone

10 µM

>0.7

>0

clone 4B61

N

2782995

Resveratrol

100 µM

>0

>-3.4


N

19264118

Resveratrol

3 µM

>0


N

24133070

Resveratrol

0.3 µM

>0


N

24133070

Resveratrol

100 µM

>-0.5

>3.7


N

19264118

Resveratrol

100 µM

>-1.4

>-12


N

19264118

Resveratrol

100 µM

>-2.3

>26.5


N

19264118

Resveratrol

100 µM

>-2.3

>16.7


N

19264118

Resveratrol

100 µM

>-2.8

>-4.8


N

19264118

Kinetin

125 ppm

>-2.9

>17.1


Y

7488181

Kinetin

625 ppm

>-2.9

>-13.2


Y

7488181

Cortisone

400 µM

>-3.2

>0

clone 4B61

N

2782995

Resveratrol

100 µM

>-3.3

>-12.1


N

19264118

Sodium
hypophosphite

10 mM

>-4.1

>-1.4


N

3721207

Resveratrol

100 µM

>-4.6

>-12.4


N

19264118

Resveratrol

100 µM

>-4.9

>5.4


N

19264118

Resveratrol

100 µM

>-5.6

>10.2


N

19264118

Resveratrol

100 µM

>-5.8

>-7.3


N

19264118

Cortisone

800 µM

>-6.3

>0

clone 4B61

N

2782995

Resveratrol

0.3 µM

>-6.5


N

24133070

Sodium
hypophosphite

10 mM

>-8.3

>-1.7


Y

3721207

Resveratrol

100 µM

>-14.5

>-14.4


N

19264118

Galactose

20 mg/ml

>-19.8

>-21.9


Y

15547319

Kinetin

625 ppm

>-20

>0


N

7488181

Rotenone

150 pM

>-20.09


MZM-0410

Y

27190265

Curare

0.00%

>-24


Y

3833547

2-Oxothiazolidine-4-carboxylate

3 mM

>-24


Y

2866912

Sodium hypophosphite

60 mM

>-24.2

>-8.1


Y

3721207

Sodium
hypophosphite

60 mM

>-24.4

>-11.2


Y

3721207

Resveratrol

100 µM

>-25.3

>-9.5


Y

19264118

Galactose

20 mg/ml

>-27.1

>-27.1


Y

15547319

Buthionine
Sulfoximine

3 mM

>-30


Y

2866912

Butylated
hydroxyanisole

50 mM

>-31.7

>-46.3


Y

9207858

Resveratrol

3 µM

>-32.3


Y

24133070

Butylated
hydroxyanisole

50 mM

>-45.9

>-40.7


Y

9207858

Sodium hypophosphite

100 mM

>-46.9

>-47.2


Y

3721207

Butylated
hydroxyanisole

100 mM

>-57.2

>-55.2


Y

9207858

Sodium
hypophosphite

100 mM

>-58.8

>-54.8


Y

3721207

Butylated
hydroxyanisole

100 mM

>-63.8

>-53.7


Y

9207858

Kinetin

3125 ppm

>-65.7

>-55.2


Y

7488181

Kinetin

3125 ppm

>-71

>-47.1


Y

7488181

Sodium
hypophosphite

500 mM

>-84.1

>-78.1


Y

3721207

Sodium hypophosphite

500 mM

>-85.3

>-78.6


Y

3721207

Sodium
hypophosphite

1 mM

>-88.5

>-91.4


Y

3721207

Sodium
hypophosphite

1 mM

>-89.8

>-94.9


Y

3721207

Powdered
Broccoli Lyophilisate

1%


San
Bernardino

Y

23321956

L-deprenyl

1 mg/kg


Beagles

ND

9307048

L-deprenyl

0.05
mg/kg/day


>16.4


Y

9258898

Melatonin

10 mg/L


>17.9


N

9406982

Reference: HAGR
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