Life extension by compounds in Drosophila Melanogaster – Part 4

Name of Formulation Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance (Yes: Y, No: N) Reference
Sevelamer 1% 16 yw Y 22942172
Stachys lavandulifolia ethanol extract 4 µl/100 ml media 16 14 Oregon R Y 20738162
Dimethyl Sulfide 1 mM 16.04 w1118 Y 27790859
Ludwigia octovalvis extract 100 µg/ml 16.1 Canton S Y 24338263
Curcumin 100 mM 16.3 25 Ra Y 23063786
Rapamycin 5 µM 16.35 -2.89 Dahomey Y 28025308
D-chiro-inositol 16.6 Canton S Y 22843669
Epitalon 1*10^-9 % 16.6 Canton S Y 11087911
Everolimus 3 mM 16.6 Oregon R Y 22363408
Tert-butyl hydroperoxide 1 mM 16.7 w iso31 Y 29515102
Rhodiola rosea 5 mg/ml 16.7 6.6 IF Y 24472572
Proanthocyanidins from Kunlun Chrysanthemum flowers 16.8 14 Oregon R+ Y 25628774
N-acetyl-L-cysteine 100 µg/ml 16.8 15.1 Oregon R Y 9447249
CU701 0.30% 16.9 Canton S Y 24305778
Minocycline 0.05mM 16.9 w1118 Y 29152127
Cinnamon Extract 25 mg/ml 17 w1118 Y 25456850
Colanic acid 350 µg/ml 17 OreR Y 28622510
Rutin 200 µM 17 Canton-S Y 28389882
Lamotrigine 12 mg/ml 17.2 Ives Y 19430925
Tyrphostin 9 300-500 µM 17.3 Oregon R Y 22363408
Tert-butyl hydroperoxide 10 mM 17.4 w iso31 Y 29515102
AG-490 300 µM 17.5 Oregon R Y 22363408
Cynomorium songaricum Rupr. 20 mg/ml 17.6 Canton S Y 22844336
Turmeric powder 5 g/L 17.6 Y 24967413
Turmeric powder 7 g/L 17.6 Y 24967413
Nectarine 0.04 17.6 2.7 Canton S Y 21406223
Glucomannan Hydrolysate 0.25% w/v 17.66 Canton-S Y 30137218
Curcumin 250 µM 18 Ives Y 20645870
Erbstatin analog 5 mM 18 Oregon R Y 22363408
HA-1004 1-10 µM 18 Oregon R Y 22363408
Pomegrenate juice 0.1 18 Canton S Y 25566518
Lithium Chloride 25 mM 18 18 Dahomey Y 27068460
Crocus Sativus Aqueous Extract 1% 18.3 w1118 Y 27878268
Tert-butyl hydroperoxide 1.25 mM 18.3 w iso31 Y 29515102
Lithium Chloride 10 mM 18.5 4 Dahomey Y 27068460
Curcumin 100 µM 19 Canton S Y 20645870
Curcumin 10 µM 19 Canton S ND 25173182
Green tea polyphenols 10 mg/ml 19 w1118 Y 25058464
Tyrphostin 1 100-300 µM 19 Oregon R Y 22363408
Carnosine 0.2 mg/l 19.5 D-32 Y 12447464
Tyrphostin AG 1478 100 µM 19.5 Oregon R Y 22363408
Tert-butyl hydroperoxide 5 mM 19.7 w iso31 Y 29515102
Baicalein 0.2mg/ml 19.8 3.97 w1118 Y 26778291
Korean mistletoe extract 50 µg/ml 19.9 Canton S Y 24337961
Carnosine 50 mg/l 20 Y 20681748
Colanic acid 35 µg/ml 20 OreR Y 28622510
KN-93 10-100 µM 20 Oregon R Y 22363408
Resveratrol 100 µm 20 Canton S Y 15254550
Black tea extract Instead of water 20.2 Oregon R Y 8326745
Glucomannan Hydrolysate 0.25% w/v 20.2 B18 Y 30137218
Tea (Camellia sinensis) extract Instead of water 20.2 Oregon R Y 8326745
2,4-dinitrophenol 0.008 20.2 0 Oregon R ND 16266268
Curcumin 1 mg/g 20.3 Wild 1-A Y 23675008
Sodium Yeast Nucleate 5 g/kg 20.3 Oregon Y 18856648
Gluconic acid 0.1 M 20.8 Oregon R ND 110607
Stachys lavandulifolia water extract 12 µl/100 ml media 21.9 8 Oregon R Y 20738162
Stachys lavandulifolia water extract 12 µl/100 ml media 22.1 10.6 Oregon R Y 20738162
Gluconic acid 0.25 M 22.2 Oregon R ND 110607
Rosa damascena extract 22.4 12.7 B Y 21928072
Tyrphostin AG 1295 300-500 µM 22.5 Oregon R Y 22363408
Tert-butyl hydroperoxide 5 mM 22.6 Canton-S Y 29515102
Tert-butyl hydroperoxide 1 mM 22.7 Canton-S Y 29515102
PP2 AG1879 300 µM 22.8 Oregon R Y 22363408
Minocycline 0.05mM 22.9 w1118 Y 29152127
3,4-dihydroxybenzaldehyde 1 mM 23 yw (y1w67c23) Y 22809229
Fisetin 100 µm 23 Canton S Y 15254550
Ibuprofen 1 µM 23 Canton-S Y 28066251
Nordihydroguaiaretic acid 3 mg/ml 23 Oregon-R-C Y 25380600
Quercetin dihydrate 1 mM 23 Oregon R Y 22363408
Lithium Chloride 25 mM 23 13.5 Dahomey Y 27068460
Trichostatin A 10 µM 23.3 37 Canton S Y 15346199
SP600125 10 mM 23.5 Oregon R Y 22363408
Rutin 400 µM 23.52 Canton-S Y 28389882
Rhodiola rosea extract 25 mg/mL 24 16 Y 19634056
Rhodiola rosea extract 25 mg/mL 24 31 Y 19634056
Ludwigia octovalvis extract 100 µg/ml 24.2 Canton S Y 24338263
Dimethyl Sulfide 100 µM 24.25 w1118 Y 27790859
Carnosine 200 mg/l 24.3 D-32 Y 12447464
Lithocholic acid 50 µM 24.94 15.39 w1118 Y 30051966
Simvastatin 240 µM 25 Y 22737247
Curcumin 100 mM 25 20.2 Ra Y 23063786
Curcumin 100 mM 25.5 0 Ra Y 23063786
Curcumin 100 mM 25.5 0 Ra Y 26136617
Curcumin 1 mg/g 25.8 -5.2 Oregon R Y 22653297
Carnosine 2 mg/l 26.4 D-32 Y 12447464
Minocycline 0.05mM 26.7 Canton S Y 29152127
Stachys lavandulifolia ethanol extract 12 µl/100 ml media 26.8 21.3 Oregon R Y 20738162
N-acetyl-L-cysteine 10 mg/ml 26.8 24.5 Oregon R Y 9447249
PD-98059 300-1000 µM 27 Oregon R Y 22363408
Torin 1 0.5 µM 27.27 8.33 Dahomey Y 29329306
Trichostatin A 10 µM 27.3 37.9 Canton S Y 15346199
Calcium Pantothenate 0.5g/kg 27.8 Oregon Y 18856647
Tert-butyl hydroperoxide 5 mM 28.4 Canton-S Y 29515102
Diiodomethane 10 µg/ml 29.3 ND 412727
Rutin 200 µM 30 Canton-S Y 28389882
Spermidine 1 mM 30 w1118 Y 19801973
Cranberry extract 0.02 30.1 Canton S Y 24316039
SB203580 300 µM 30.3 Oregon R Y 22363408
Thiazolidine carboxylic acid 0.3% wt/vol 31 Oregon R Y 6821144
Stachys lavandulifolia ethanol extract 12 µl/100 ml media 31.3 22 Oregon R Y 20738162
Rosa damascena extract 31.7 13 B Y 21928072
Stachys lavandulifolia water extract 20 µl/100 ml media 32 14.9 Oregon R Y 20738162
Cordyceps sinensis oral liquid 0.20 mg/ml 32 15.4 Oregon-K Y 26239097
Curcumin 10 µM 34 Canton S ND 25173182
Staurosporine 30-50 µM 34.8 Oregon R Y 22363408
Stachys lavandulifolia water extract 20 µl/100 ml media 35.6 14 Oregon R Y 20738162
Rhodiola rosea root extract NA 36 w1118 Y 23704949
S,S-trolox-carnosine 50 mg/L 36 Y 20681748
Torin 1 1 µM 36.36 16.6 Dahomey Y 29329306
Cinnamon Extract 75 mg/ml 37 w1118 Y 25456850
Rhodiola rosea root extract NA 40 w1118 Y 23704949
4-phenylbutyrate 5 mM 40 41 Canton S ND 11792861
Epicatechin 0.1 mM/l 42 Canton S Y 21525262
Rutin 400 µM 43.33 Canton-S Y 28389882
Stachys lavandulifolia ethanol extract 20 µl/100 ml media 44.4 8 Oregon R Y 20738162
Curcumin 100 mM 46.8 38 Ra Y 23063786
Curcumin 100 mM 46.8 38 Ra Y 26136617
Minocycline 0.05 mM 49 Oregon Y 22330257
Curcumin 100 mM 49 49 Ra Y 23063786
Torin 1 5 µM 50 13.89 Dahomey Y 29329306
Minocycline 0.87 mM 50 25 Oregon R Y 23185716
Minocycline 0.87 mM 50 66 Oregon R Y 23185716
Rasayana 1 drop 51.1 Oregon-K Y 21836798
Rasayana 1 drop 55 Oregon-K Y 21836798
Stachys lavandulifolia ethanol extract 20 µl/100 ml media 55.7 36 Oregon R Y 20738162
Torin 1 10 µM 59.09 0 Dahomey Y 29329306
Minocycline 0.05 mM 63 Oregon ND 23947005
Guduchi Churna 0.7 g/100 ml 85.91 Oregon-K Y 28827958
Guduchi Churna 0.50g/100ml 155.65 Oregon-K Y 28827958
Guduchi Churna 0.25g/100ml 193.83 Oregon-K Y 28827958
Reference: HAGR