Life extension by compounds in Drosophila Melanogaster – Part 4

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Name of
Formulation
Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance
(Yes: Y, No: N)

Reference

Sevelamer

1%

16


yw

Y

22942172

Stachys
lavandulifolia ethanol extract

4 µl/100
ml media

16

14

Oregon R

Y

20738162

Dimethyl
Sulfide

1 mM

16.04


w1118

Y

27790859

Ludwigia
octovalvis extract

100 µg/ml

16.1


Canton S

Y

24338263

Curcumin

100 mM

16.3

25

Ra

Y

23063786

Rapamycin

5 µM

16.35

-2.89

Dahomey

Y

28025308

D-chiro-inositol


16.6


Canton S

Y

22843669

Epitalon

1*10^-9 %

16.6


Canton S

Y

11087911

Everolimus

3 mM

16.6


Oregon R

Y

22363408

Tert-butyl
hydroperoxide

1 mM

16.7


w iso31

Y

29515102

Rhodiola
rosea

5 mg/ml

16.7

6.6

IF

Y

24472572

Proanthocyanidins
from Kunlun Chrysanthemum flowers


16.8

14

Oregon R+

Y

25628774

N-acetyl-L-cysteine

100 µg/ml

16.8

15.1

Oregon R

Y

9447249

CU701

0.30%

16.9


Canton S

Y

24305778

Minocycline

0.05mM

16.9


w1118

Y

29152127

Cinnamon
Extract

25 mg/ml

17


w1118

Y

25456850

Colanic
acid

350 µg/ml

17


OreR

Y

28622510

Rutin

200 µM

17


Canton-S

Y

28389882

Lamotrigine

12 mg/ml

17.2


Ives

Y

19430925

Tyrphostin
9

300-500 µM

17.3


Oregon R

Y

22363408

Tert-butyl
hydroperoxide

10 mM

17.4


w iso31

Y

29515102

AG-490

300 µM

17.5


Oregon R

Y

22363408

Cynomorium
songaricum Rupr.

20 mg/ml

17.6


Canton S

Y

22844336

Turmeric
powder

5 g/L

17.6


Y

24967413

Turmeric
powder

7 g/L

17.6


Y

24967413

Nectarine

0.04

17.6

2.7

Canton S

Y

21406223

Glucomannan
Hydrolysate

0.25% w/v

17.66


Canton-S

Y

30137218

Curcumin

250 µM

18


Ives

Y

20645870

Erbstatin
analog

5 mM

18


Oregon R

Y

22363408

HA-1004

1-10 µM

18


Oregon R

Y

22363408

Pomegrenate
juice

0.1

18


Canton S

Y

25566518

Lithium
Chloride

25 mM

18

18

Dahomey

Y

27068460

Crocus
Sativus Aqueous Extract

1%

18.3


w1118

Y

27878268

Tert-butyl
hydroperoxide

1.25 mM

18.3


w iso31

Y

29515102

Lithium
Chloride

10 mM

18.5

4

Dahomey

Y

27068460

Curcumin

100 µM

19


Canton S

Y

20645870

Curcumin

10 µM

19


Canton S

ND

25173182

Green tea
polyphenols

10 mg/ml

19


w1118

Y

25058464

Tyrphostin
1

100-300 µM

19


Oregon R

Y

22363408

Carnosine

0.2 mg/l

19.5


D-32

Y

12447464

Tyrphostin
AG 1478

100 µM

19.5


Oregon R

Y

22363408

Tert-butyl
hydroperoxide

5 mM

19.7


w iso31

Y

29515102

Baicalein

0.2mg/ml

19.8

3.97

w1118

Y

26778291

Korean
mistletoe extract

50 µg/ml

19.9


Canton S

Y

24337961

Carnosine

50 mg/l

20


Y

20681748

Colanic
acid

35 µg/ml

20


OreR

Y

28622510

KN-93

10-100 µM

20


Oregon R

Y

22363408

Resveratrol

100 µm

20


Canton S

Y

15254550

Black tea
extract

Instead of
water

20.2


Oregon R

Y

8326745

Glucomannan
Hydrolysate

0.25% w/v

20.2


B18

Y

30137218

Tea
(Camellia sinensis) extract

Instead of
water

20.2


Oregon R

Y

8326745

2,4-dinitrophenol

0.008

20.2

0

Oregon R

ND

16266268

Curcumin

1 mg/g

20.3


Wild 1-A

Y

23675008

Sodium
Yeast Nucleate

5 g/kg

20.3


Oregon

Y

18856648

Gluconic
acid

0.1 M

20.8


Oregon R

ND

110607

Stachys
lavandulifolia water extract

12 µl/100
ml media

21.9

8

Oregon R

Y

20738162

Stachys
lavandulifolia water extract

12 µl/100
ml media

22.1

10.6

Oregon R

Y

20738162

Gluconic
acid

0.25 M

22.2


Oregon R

ND

110607

Rosa
damascena extract


22.4

12.7

B

Y

21928072

Tyrphostin
AG 1295

300-500 µM

22.5


Oregon R

Y

22363408

Tert-butyl
hydroperoxide

5 mM

22.6


Canton-S

Y

29515102

Tert-butyl
hydroperoxide

1 mM

22.7


Canton-S

Y

29515102

PP2 AG1879

300 µM

22.8


Oregon R

Y

22363408

Minocycline

0.05mM

22.9


w1118

Y

29152127

3,4-dihydroxybenzaldehyde

1 mM

23


yw
(y1w67c23)

Y

22809229

Fisetin

100 µm

23


Canton S

Y

15254550

Ibuprofen

1 µM

23


Canton-S

Y

28066251

Nordihydroguaiaretic
acid

3 mg/ml

23


Oregon-R-C

Y

25380600

Quercetin
dihydrate

1 mM

23


Oregon R

Y

22363408

Lithium
Chloride

25 mM

23

13.5

Dahomey

Y

27068460

Trichostatin
A

10 µM

23.3

37

Canton S

Y

15346199

SP600125

10 mM

23.5


Oregon R

Y

22363408

Rutin

400 µM

23.52


Canton-S

Y

28389882

Rhodiola
rosea extract

25 mg/mL

24

16


Y

19634056

Rhodiola
rosea extract

25 mg/mL

24

31


Y

19634056

Ludwigia
octovalvis extract

100 µg/ml

24.2


Canton S

Y

24338263

Dimethyl
Sulfide

100 µM

24.25


w1118

Y

27790859

Carnosine

200 mg/l

24.3


D-32

Y

12447464

Lithocholic
acid

50 µM

24.94

15.39

w1118

Y

30051966

Simvastatin

240 µM

25


Y

22737247

Curcumin

100 mM

25

20.2

Ra

Y

23063786

Curcumin

100 mM

25.5

0

Ra

Y

23063786

Curcumin

100 mM

25.5

0

Ra

Y

26136617

Curcumin

1 mg/g

25.8

-5.2

Oregon R

Y

22653297

Carnosine

2 mg/l

26.4


D-32

Y

12447464

Minocycline

0.05mM

26.7


Canton S

Y

29152127

Stachys
lavandulifolia ethanol extract

12 µl/100
ml media

26.8

21.3

Oregon R

Y

20738162

N-acetyl-L-cysteine

10 mg/ml

26.8

24.5

Oregon R

Y

9447249

PD-98059

300-1000
µM

27


Oregon R

Y

22363408

Torin 1

0.5 µM

27.27

8.33

Dahomey

Y

29329306

Trichostatin
A

10 µM

27.3

37.9

Canton S

Y

15346199

Calcium
Pantothenate

0.5g/kg

27.8


Oregon

Y

18856647

Tert-butyl
hydroperoxide

5 mM

28.4


Canton-S

Y

29515102

Diiodomethane

10 µg/ml

29.3


ND

412727

Rutin

200 µM

30


Canton-S

Y

28389882

Spermidine

1 mM

30


w1118

Y

19801973

Cranberry
extract

0.02

30.1


Canton S

Y

24316039

SB203580

300 µM

30.3


Oregon R

Y

22363408

Thiazolidine
carboxylic acid

0.3%
wt/vol

31


Oregon R

Y

6821144

Stachys
lavandulifolia ethanol extract

12 µl/100
ml media

31.3

22

Oregon R

Y

20738162

Rosa
damascena extract


31.7

13

B

Y

21928072

Stachys
lavandulifolia water extract

20 µl/100
ml media

32

14.9

Oregon R

Y

20738162

Cordyceps
sinensis oral liquid

0.20 mg/ml

32

15.4

Oregon-K

Y

26239097

Curcumin

10 µM

34


Canton S

ND

25173182

Staurosporine

30-50 µM

34.8


Oregon R

Y

22363408

Stachys
lavandulifolia water extract

20 µl/100
ml media

35.6

14

Oregon R

Y

20738162

Rhodiola
rosea root extract

NA

36


w1118

Y

23704949

S,S-trolox-carnosine

50 mg/L

36


Y

20681748

Torin 1

1 µM

36.36

16.6

Dahomey

Y

29329306

Cinnamon
Extract

75 mg/ml

37


w1118

Y

25456850

Rhodiola
rosea root extract

NA

40


w1118

Y

23704949

4-phenylbutyrate

5 mM

40

41

Canton S

ND

11792861

Epicatechin

0.1 mM/l

42


Canton S

Y

21525262

Rutin

400 µM

43.33


Canton-S

Y

28389882

Stachys
lavandulifolia ethanol extract

20 µl/100
ml media

44.4

8

Oregon R

Y

20738162

Curcumin

100 mM

46.8

38

Ra

Y

23063786

Curcumin

100 mM

46.8

38

Ra

Y

26136617

Minocycline

0.05 mM

49


Oregon

Y

22330257

Curcumin

100 mM

49

49

Ra

Y

23063786

Torin 1

5 µM

50

13.89

Dahomey

Y

29329306

Minocycline

0.87 mM

50

25

Oregon R

Y

23185716

Minocycline

0.87 mM

50

66

Oregon R

Y

23185716

Rasayana

1 drop

51.1


Oregon-K

Y

21836798

Rasayana

1 drop

55


Oregon-K

Y

21836798

Stachys
lavandulifolia ethanol extract

20 µl/100
ml media

55.7

36

Oregon R

Y

20738162

Torin 1

10 µM

59.09

0

Dahomey

Y

29329306

Minocycline

0.05 mM

63


Oregon

ND

23947005

Guduchi
Churna

0.7 g/100
ml

85.91


Oregon-K

Y

28827958

Guduchi
Churna

0.50g/100ml

155.65


Oregon-K

Y

28827958

Guduchi
Churna

0.25g/100ml

193.83


Oregon-K

Y

28827958

Reference: HAGR
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