Life extension by compounds in Drosophila Melanogaster – Part 3

Part 1 Part 2 Part 3 Part 4

Name of Formulation Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance (Yes: Y, No: N) Reference
Green tea extract 5 mg/ml 7.8 5.3 Oregon-R-C Y 17440995
Lactic acid 0.001 M 8 Oregon R ND 110607
Pomegrenate juice 0.1 8 Canton S Y 25566518
Indirubin 3 mM 8.2 Oregon R Y 22363408
Resveratrol 3.2 µM 8.2 Canton S N 17875315
Sodium butyrate 100 mM 8.3 Ra Y 23044027
Sodium butyrate 10 mM 8.3 Ra Y 23044027
Sodium butyrate 10 mM 8.3 12 Ra Y 26136617
2,5-Dimethyl-Celecoxib 0.5 µM 8.4 11.32 Dahomey Y 28025308
Freeze dried royal jelly 1% w/v 8.5 -4 Oregon R Y 23132575
Baicalein 0.04mg/ml 8.53 5.7 w1118 Y 26778291
Green tea extract Instead of water 8.6 Oregon R Y 8326745
Pinitol 8.7 Canton S Y 22843669
Crocus Sativus Aqueous Extract 1% 8.8 w1118 Y 27878268
Royal Jelly Protein 1.25% 8.96 6.9 Canton-S Y 27388939
Curcumin 25 µM 9 Canton S ND 25173182
2,5-Dimethyl-Celecoxib 0.5 µM 9.07 3.39 Dahomey Y 28025308
Beta-Guanidinopropionic acid 900 mM 9.1 w1118 Y 26120775
Resveratrol 32 µM 9.1 Canton S N 17875315
Resveratrol 32 µM 9.1 Dahomey N 17875315
Gluconic acid 0.5 M 9.3 Oregon R ND 110607
N-Acetyl Cysteine 100 nM 9.3 7.8 Canton-S Y 30243020
Baicalein 1 mg/ml 9.32 4.66 w1118 Y 26778291
Sodium borate 0.25 mM 9.5 Oregon R N 7889879
Apple polyphenols NA 10 Oregon R Y 21319854
Black tea extract 10 mg/ml 10 Y 19770032
Blueberry extract 5 mg/ml 10 Y 22197903
Glucomannan Hydrolysate 0.25% w/v 10 DGRP-85 Y 30137218
Pyrrolidine dithiocarbamate 125 µM 10 Canton S Y 24096697
Glucomannan Hydrolysate 0.25% w/v 10.1 DGRP-38 Y 30137218
J147 0.1µM 10.35 1.39 (w1118/+) Y 29316249
Cranberry anthocyanin extract 20 mg/ml 10.4 5.1 Oregon-R-C Y 26159161
Epitalon 1*10^-7 % 10.8 Canton S Y 11087911
jujube fruit powder 150 mg/ml 11.1 w1118 Y 28251407
Epitalon 5*10^-6 % 11.3 Canton S Y 11087911
AU701 0.30% 11.4 Canton S Y 24305778
Cynomorium songaricum Rupr. 30 mg/ml 11.4 Canton S Y 22844336
Lutein 0.1 mg/ml 11.4 Y 23993264
Glucomannan Hydrolysate 0.25% w/v 11.7 Oregon-R Y 30137218
Epitalon 1*10^-7 % 11.8 Canton S Y 11087911
Rhodiola rosea 30 mg/mL 11.9 Y 17990971
Tert-butyl hydroperoxide 5 mM 11.9 w iso31 Y 29515102
Epitalon 1*10^-8 % 12 Canton S Y 11087911
Lactic acid 0.01M 12 Oregon R ND 110607
Pyrrolidine dithiocarbamate 125 µM 12 Canton S Y 24096697
Sesame 2 mg/ml 12 Oregon R Y 23291977
Trametinib 15.6 µM 12 white Dahomey Y 26119340
Alpha-lipoic acid 0.01% 12 5 Canton S ND 15328413
Resveratrol 200 µM 12.1 Dahomey N 17875315
Tert-butyl hydroperoxide 2.5 mM 12.1 w iso31 Y 29515102
Tea (Camellia sinensis) extract Instead of water 12.2 Oregon R Y 8326745
Tert-butyl hydroperoxide 1 mM 12.2 w iso31 Y 29515102
Gluconic acid 0.1 M 12.3 Oregon R ND 110607
Stachys lavandulifolia ethanol extract 4 µl/100 ml media 12.4 6.4 Oregon R Y 20738162
Royal Jelly Protein 2.50% 12.43 5.17 Canton-S Y 27388939
Pinitol 12.5 Canton S Y 22843669
Sodium butyrate 10 mM 12.5 Ra Y 23044027
J147 2 µM 12.5 -8.33 (w1118/+) Y 29316249
Curcumin 1 mg/g 12.6 13 Oregon R Y 22653297
ursolic acid 50 µmol/L 12.78 w1118 Y 30496629
Epitalon 1*10^-6 % 12.8 Canton S Y 11087911
Rapamycin 10 µM 12.98 -2.89 Dahomey Y 28025308
3,4-dihydroxybenzaldehyde 0.3 mM 13 yw (y1w67c23) Y 22809229
3,4-dihydroxybenzaldehyde 3 mM 13 yw (y1w67c23) Y 22809229
Quercetin 1 µM 13 Canton-S Y 28066251
Rapamycin 200 µM 13 white Dahomey Y 20074526
Quercetin 1 µM 13 6 Canton S Y 28066251
Lithium Chloride 10 mM 13 13 Dahomey Y 27068460
Platanus orientalis Extract 0.1µg/ml 13.02 11.94 Oregon R Y 28887920
Beta-Guanidinopropionic acid 900 mM 13.3 w1118 Y 26120775
Epitalon 1*10^-8 % 13.4 Canton S Y 11087911
Glucomannan Hydrolysate 0.25% w/v 13.4 DGRP-21 Y 30137218
Korean red ginseng tonic 12 µg/ml 13.5 w1118 Y 24265871
Dimethyl Sulfide 10 µM 13.56 w1118 Y 27790859
Minocycline 0.05mM 13.6 Canton S Y 29152127
Rhodiola rosea 5 mg/ml 13.6 3.4 IF Y 24472572
Rhodiola rosea 10 mg/ml 13.6 3.9 IF Y 24472572
Royal Jelly Protein 5% 13.87 10.34 Canton-S Y 27388939
Proanthocyanidins from Kunlun Chrysanthemum flowers 13.9 8.9 Oregon R+ Y 25628774
Black rice extract 30 mg/ml 14 Oregon R Y 22930061
Lactic acid 0.1M 14 Oregon R ND 110607
Rhodiola rosea 30 mg/mL 14 Y 17990971
SkQ1 20 pM-20 nM 14 Y 19120018
Vitamin E 0.4% wt/vol 14 Oregon R Y 6821144
LY-294002 5 µM 14 22.5 Canton S Y 20017609
Melatonin 100 µg/ml 14 33 Oregon R Y 11909680
N-acetyl-L-cysteine 1 mg/ml 14.1 15.1 Oregon R ND 9447249
Gluconic acid 0.1 M 14.3 Oregon R ND 110607
Rhodiola rosea 10 mg/ml 14.3 6 IF Y 24472572
LY-294002 5 µM 14.3 16.3 Canton S Y 20017609
HA-1077 10 µM 14.5 Oregon R Y 22363408
Korean red ginseng tonic 1.2 µg/ml 14.5 w1118 Y 24265871
Rosa damascena extract 14.5 6.4 w1118 Y 21928072
Omega-3 Monoacylglyceride Docosahexaenoic acid 0.3 mg/mL 14.58 6.56 w1118 Y 30453574
Omega-3 Monoacylglyceride Docosahexaenoic acid 0.3 mg/mL 14.58 15.32 w1118 Y 30453574
Sodium butyrate 10 mM 14.6 9.1 Ra Y 26136617
Glucomannan Hydrolysate 0.25% w/v 14.88 B18 Y 30137218
Fucoxanthin 1 µM 14.9 4.4 Canton S Y 29504896
D-chiro-inositol 15 Canton S Y 22843669
Pyrrolidine dithiocarbamate 20 mg/l 15 Y 21483034
Aurintricarboxylic acid 0.5 mM 15 0 Oregon R ND 15621204
Resveratrol 10 µM 15.2 Dahomey N 17875315
Resveratrol 1 µM 15.2 Dahomey N 17875315
Cynomorium songaricum Rupr. 10 mg/ml 15.3 Canton S Y 22844336
Aronia extract 2.5 mg/mL 15.38 8.88 Canton-S Y 30263675
Lactic acid 0.25M 15.4 Oregon R ND 110607
Lamotrigine 12 mg/ml 15.4 Ives Y 19430925
Lactic acid 0.1M 15.5 Oregon R ND 110607
Curcumin 0.5 mg/g 15.5 -1.9 Oregon R Y 22653297
Proanthocyanidins from Kunlun Chrysanthemum flowers 15.5 10.4 Oregon R+ Y 25628774
Tiliroside 100 µM 15.56 5.88 Oregon R Y 28887920
Minocycline 0.36mM 15.6 w1118 Y 29152127
Trichostatin A 10 µmol/L 15.6 Canton S ND 15695762
Epigallocatechin-3-gallate 10 mg/ml 15.7 Y 26375250
Minocycline 0.36mM 15.7 Canton S Y 29152127
Tea (Camellia sinensis) extract Instead of water 15.7 Oregon R Y 8326745
Green tea extract 10 mg/ml 15.7 5.3 Oregon-R-C Y 17440995
Epicatechin 1 µM 16 Canton-S Y 28066251
Epithalamin NA 16 Y 9701766
Pyrrolidine dithiocarbamate 20 mg/l 16 Y 21483034
Resveratrol 100 µm 16 Canton S Y 15254550
S,S-trolox-carnosine 50 mg/L 16 Y 20681748
Reference: HAGR