Life extension by compounds in Drosophila Melanogaster – Part 3

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Name of
Formulation
Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance
(Yes: Y, No: N)

Reference

Green tea
extract

5 mg/ml

7.8

5.3

Oregon-R-C

Y

17440995

Lactic acid

0.001 M

8


Oregon R

ND

110607

Pomegrenate
juice

0.1

8


Canton S

Y

25566518

Indirubin

3 mM

8.2


Oregon R

Y

22363408

Resveratrol

3.2 µM

8.2


Canton S

N

17875315

Sodium
butyrate

100 mM

8.3


Ra

Y

23044027

Sodium
butyrate

10 mM

8.3


Ra

Y

23044027

Sodium
butyrate

10 mM

8.3

12

Ra

Y

26136617

2,5-Dimethyl-Celecoxib

0.5 µM

8.4

11.32

Dahomey

Y

28025308

Freeze
dried royal jelly

1% w/v

8.5

-4

Oregon R

Y

23132575

Baicalein

0.04mg/ml

8.53

5.7

w1118

Y

26778291

Green tea
extract

Instead of
water

8.6


Oregon R

Y

8326745

Pinitol


8.7


Canton S

Y

22843669

Crocus
Sativus Aqueous Extract

1%

8.8


w1118

Y

27878268

Royal Jelly
Protein

1.25%

8.96

6.9

Canton-S

Y

27388939

Curcumin

25 µM

9


Canton S

ND

25173182

2,5-Dimethyl-Celecoxib

0.5 µM

9.07

3.39

Dahomey

Y

28025308

Beta-Guanidinopropionic
acid

900 mM

9.1


w1118

Y

26120775

Resveratrol

32 µM

9.1


Canton S

N

17875315

Resveratrol

32 µM

9.1


Dahomey

N

17875315

Gluconic
acid

0.5 M

9.3


Oregon R

ND

110607

N-Acetyl
Cysteine

100 nM

9.3

7.8

Canton-S

Y

30243020

Baicalein

1 mg/ml

9.32

4.66

w1118

Y

26778291

Sodium
borate

0.25 mM

9.5


Oregon R

N

7889879

Apple
polyphenols

NA

10


Oregon R

Y

21319854

Black tea
extract

10 mg/ml

10


Y

19770032

Blueberry
extract

5 mg/ml

10


Y

22197903

Glucomannan
Hydrolysate

0.25% w/v

10


DGRP-85

Y

30137218

Pyrrolidine
dithiocarbamate

125 µM

10


Canton S

Y

24096697

Glucomannan
Hydrolysate

0.25% w/v

10.1


DGRP-38

Y

30137218

J147

0.1µM

10.35

1.39

(w1118/+)

Y

29316249

Cranberry
anthocyanin extract

20 mg/ml

10.4

5.1

Oregon-R-C

Y

26159161

Epitalon

1*10^-7 %

10.8


Canton S

Y

11087911

jujube fruit
powder

150 mg/ml

11.1


w1118

Y

28251407

Epitalon

5*10^-6 %

11.3


Canton S

Y

11087911

AU701

0.30%

11.4


Canton S

Y

24305778

Cynomorium
songaricum Rupr.

30 mg/ml

11.4


Canton S

Y

22844336

Lutein

0.1 mg/ml

11.4


Y

23993264

Glucomannan
Hydrolysate

0.25% w/v

11.7


Oregon-R

Y

30137218

Epitalon

1*10^-7 %

11.8


Canton S

Y

11087911

Rhodiola
rosea

30 mg/mL

11.9


Y

17990971

Tert-butyl
hydroperoxide

5 mM

11.9


w iso31

Y

29515102

Epitalon

1*10^-8 %

12


Canton S

Y

11087911

Lactic acid

0.01M

12


Oregon R

ND

110607

Pyrrolidine
dithiocarbamate

125 µM

12


Canton S

Y

24096697

Sesame

2 mg/ml

12


Oregon R

Y

23291977

Trametinib

15.6 µM

12


white
Dahomey

Y

26119340

Alpha-lipoic
acid

0.01%

12

5

Canton S

ND

15328413

Resveratrol

200 µM

12.1


Dahomey

N

17875315

Tert-butyl
hydroperoxide

2.5 mM

12.1


w iso31

Y

29515102

Tea
(Camellia sinensis) extract

Instead of
water

12.2


Oregon R

Y

8326745

Tert-butyl
hydroperoxide

1 mM

12.2


w iso31

Y

29515102

Gluconic
acid

0.1 M

12.3


Oregon R

ND

110607

Stachys
lavandulifolia ethanol extract

4 µl/100
ml media

12.4

6.4

Oregon R

Y

20738162

Royal Jelly
Protein

2.50%

12.43

5.17

Canton-S

Y

27388939

Pinitol


12.5


Canton S

Y

22843669

Sodium
butyrate

10 mM

12.5


Ra

Y

23044027

J147

2 µM

12.5

-8.33

(w1118/+)

Y

29316249

Curcumin

1 mg/g

12.6

13

Oregon R

Y

22653297

ursolic
acid

50 µmol/L

12.78


w1118

Y

30496629

Epitalon

1*10^-6 %

12.8


Canton S

Y

11087911

Rapamycin

10 µM

12.98

-2.89

Dahomey

Y

28025308

3,4-dihydroxybenzaldehyde

0.3 mM

13


yw
(y1w67c23)

Y

22809229

3,4-dihydroxybenzaldehyde

3 mM

13


yw
(y1w67c23)

Y

22809229

Quercetin

1 µM

13


Canton-S

Y

28066251

Rapamycin

200 µM

13


white
Dahomey

Y

20074526

Quercetin

1 µM

13

6

Canton S

Y

28066251

Lithium
Chloride

10 mM

13

13

Dahomey

Y

27068460

Platanus
orientalis Extract

0.1µg/ml

13.02

11.94

Oregon R

Y

28887920

Beta-Guanidinopropionic
acid

900 mM

13.3


w1118

Y

26120775

Epitalon

1*10^-8 %

13.4


Canton S

Y

11087911

Glucomannan
Hydrolysate

0.25% w/v

13.4


DGRP-21

Y

30137218

Korean red
ginseng tonic

12 µg/ml

13.5


w1118

Y

24265871

Dimethyl
Sulfide

10 µM

13.56


w1118

Y

27790859

Minocycline

0.05mM

13.6


Canton S

Y

29152127

Rhodiola
rosea

5 mg/ml

13.6

3.4

IF

Y

24472572

Rhodiola
rosea

10 mg/ml

13.6

3.9

IF

Y

24472572

Royal Jelly
Protein

5%

13.87

10.34

Canton-S

Y

27388939

Proanthocyanidins
from Kunlun Chrysanthemum flowers


13.9

8.9

Oregon R+

Y

25628774

Black rice
extract

30 mg/ml

14


Oregon R

Y

22930061

Lactic acid

0.1M

14


Oregon R

ND

110607

Rhodiola
rosea

30 mg/mL

14


Y

17990971

SkQ1

20 pM-20
nM

14


Y

19120018

Vitamin E

0.4%
wt/vol

14


Oregon R

Y

6821144

LY-294002

5 µM

14

22.5

Canton S

Y

20017609

Melatonin

100 µg/ml

14

33

Oregon R

Y

11909680

N-acetyl-L-cysteine

1 mg/ml

14.1

15.1

Oregon R

ND

9447249

Gluconic
acid

0.1 M

14.3


Oregon R

ND

110607

Rhodiola
rosea

10 mg/ml

14.3

6

IF

Y

24472572

LY-294002

5 µM

14.3

16.3

Canton S

Y

20017609

HA-1077

10 µM

14.5


Oregon R

Y

22363408

Korean red
ginseng tonic

1.2 µg/ml

14.5


w1118

Y

24265871

Rosa
damascena extract


14.5

6.4

w1118

Y

21928072

Omega-3
Monoacylglyceride Docosahexaenoic acid

0.3 mg/mL

14.58

6.56

w1118

Y

30453574

Omega-3
Monoacylglyceride Docosahexaenoic acid

0.3 mg/mL

14.58

15.32

w1118

Y

30453574

Sodium
butyrate

10 mM

14.6

9.1

Ra

Y

26136617

Glucomannan
Hydrolysate

0.25% w/v

14.88


B18

Y

30137218

Fucoxanthin

1 µM

14.9

4.4

Canton S

Y

29504896

D-chiro-inositol


15


Canton S

Y

22843669

Pyrrolidine
dithiocarbamate

20 mg/l

15


Y

21483034

Aurintricarboxylic
acid

0.5 mM

15

0

Oregon R

ND

15621204

Resveratrol

10 µM

15.2


Dahomey

N

17875315

Resveratrol

1 µM

15.2


Dahomey

N

17875315

Cynomorium
songaricum Rupr.

10 mg/ml

15.3


Canton S

Y

22844336

Aronia
extract

2.5 mg/mL

15.38

8.88

Canton-S

Y

30263675

Lactic acid

0.25M

15.4


Oregon R

ND

110607

Lamotrigine

12 mg/ml

15.4


Ives

Y

19430925

Lactic acid

0.1M

15.5


Oregon R

ND

110607

Curcumin

0.5 mg/g

15.5

-1.9

Oregon R

Y

22653297

Proanthocyanidins
from Kunlun Chrysanthemum flowers


15.5

10.4

Oregon R+

Y

25628774

Tiliroside

100 µM

15.56

5.88

Oregon R

Y

28887920

Minocycline

0.36mM

15.6


w1118

Y

29152127

Trichostatin
A

10 µmol/L

15.6


Canton S

ND

15695762

Epigallocatechin-3-gallate

10 mg/ml

15.7


Y

26375250

Minocycline

0.36mM

15.7


Canton S

Y

29152127

Tea
(Camellia sinensis) extract

Instead of
water

15.7


Oregon R

Y

8326745

Green tea
extract

10 mg/ml

15.7

5.3

Oregon-R-C

Y

17440995

Epicatechin

1 µM

16


Canton-S

Y

28066251

Epithalamin

NA

16


Y

9701766

Pyrrolidine
dithiocarbamate

20 mg/l

16


Y

21483034

Resveratrol

100 µm

16


Canton S

Y

15254550

S,S-trolox-carnosine

50 mg/L

16


Y

20681748

Reference: HAGR
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