Life extension by compounds in Drosophila Melanogaster – Part 2

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Name of
Formulation
Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance
(Yes: Y, No: N)

Reference

Resveratrol

3.2 µM

-2.8


Dahomey

N

17875315

Resveratrol

32 µM

-2.8


Dahomey

N

17875315

Resveratrol

200 µM

-2.8


Dahomey

N

17875315

Resveratrol

1000 µM

-2.8


Dahomey

N

17875315

Quercetin

0.3µM

-2.8

-13.07

Canton S

Y

28066251

Resveratrol

200 µM

-2.1


Canton S

N

22083438

Resveratrol

32 µM

-2


Canton S

N

17875315

Resveratrol

1000 µM

-2


Canton S

N

17875315

Lactic acid

0.5M

-1.9


Oregon R

ND

110607

Gluconic
acid

0.001 M

-1.8


Oregon R

ND

110607

Resveratrol

200 µM

-1.5


Canton S

N

22083438

Resveratrol

100 µM

-1.4


Dahomey

Y

17875315

Resveratrol

200 µM

-1.4


Dahomey

Y

17875315

Curcumin

50 µM

-1


Canton S

ND

25173182

AU701

0.30%

-0.7


Canton S

N

24305778

CU701

0.30%

0


Canton S

N

24305778

Gluconic
acid

0.01 M

0


Oregon R

ND

110607

Gluconic
acid

0.001 M

0


Oregon R

ND

110607

Gluconic
acid

0.5M
2x/week

0


Oregon R

ND

110607

Metformin

1 mM

0


Dahomey

N

23077661

Metformin

5 mM

0


Dahomey

N

23077661

Metformin

5 mM

0


Dahomey

N

23077661

Metformin

2.5 mM

0


Dahomey

N

23077661

Resveratrol

200 µM

0


Canton S

N

17875315

Resveratrol

1 µM

0


Canton S

N

17875315

Resveratrol

3.2 µM

0


Canton S

N

17875315

Resveratrol

200 µM

0


Canton S

N

17875315

Resveratrol

100 µM

0


Canton S

N

17875315

Resveratrol

10 µM

0


Canton S

N

17875315

Resveratrol

100 µM

0


Canton S

N

17875315

Resveratrol

1 µM

0


Canton S

N

17875315

Resveratrol

200 µM

0


Dahomey

N

17875315

Resveratrol

10 µM

0


Dahomey

N

17875315

Resveratrol

100 µM

0


Dahomey

N

17875315

Resveratrol

32 µM

0


Dahomey

N

17875315

Resveratrol

10 µM

0


Dahomey

N

17875315

Sodium
borate

1 µM

0


Oregon R

N

7889879

Tannic acid

1 mg/ml

0


Oregon R

N

8326745

Tannic acid

0.1 mg/ml

0


Oregon R

N

8326745

Tartaric
acid

0.001 M

0


Oregon R

ND

110607

Epicatechin

0.5 µM

0

2.24

Canton S

N

28066251

Aronia
extract

1 mg/mL

0

7.77

Canton-S

N

30263675

Resveratrol

100 µM

1


Canton S

N

22083438

Proanthocyanidins
from Kunlun Chrysanthemum flowers


1

5.1

Oregon R+

N

25628774

AU701

0.30%

1.2


Canton S

N

24305778

Resveratrol

1 µM

1.4


Dahomey

N

17875315

Cynomorium
songaricum Rupr.

10 mg/ml

1.5


Canton S

N

22844336

Sodium
borate

0.01 mM

1.5


Oregon R

Y

7889879

Caffeine

0.1 mg/ml

1.7


Oregon R

N

8326745

Calcium
lactate

0.001 M

1.8


Oregon R

ND

110607

Epicatechin

0.01 mg/ml

1.8


Oregon R

N

8326745

Resveratrol

100 µM

1.8


Canton S

N

22083438

Curcumin

5 µM

2


Canton S

ND

25173182

Resveratrol

200 µM

2


Canton S

N

17875315

Vitamin E

100 µg/ml

2


Canton S

Y

17169403

Cynomorium
songaricum Rupr.

20 mg/ml

2.2


Canton S

N

22844336

Rhodiola
rosea

2.5 mg/ml

2.4

-6

IF

N

24472572

Platanus
orientalis Extract

10 µg/ml

2.43

7.46

Oregon R

Y

28887920

Morphine


2.6


Oregon R

Y

21061062

Resveratrol

1 µM

2.8


Canton S

N

17875315

Resveratrol

100 µM

2.8


Canton S

N

17875315

Resveratrol

100 µM

2.8


Dahomey

N

17875315

Resveratrol

3.2 µM

2.8


Dahomey

N

17875315

Turmeric
powder

2.5 g/L

2.9


Y

24967413

Curcumin

50 µM

3


Canton S

ND

25173182

Resveratrol

1000 µM

3


Dahomey

N

17875315

Sodium
borate

0.1 mM

3


Oregon R

Y

7889879

N-(3-(aminomethyl)benzyl)acetamidine

0.03 µM

3

13

Canton S

Y

24096697

Curcumin

0.2 mg/g

3.01

4.91

Canton-S

N

30488487

Epitalon

5*10^-6 %

3.2


Canton S

N

11087911

Epitalon

1*10^-6 %

3.2


Canton S

N

11087911

Morphine


3.2


Oregon R

Y

21061062

Proanthocyanidins
from Kunlun Chrysanthemum flowers


3.2

2.9

Oregon R+

N

25628774

Platanus
orientalis Extract

1 µg/ml

3.26

1.49

Oregon R

Y

28887920

Resveratrol

1000 µM

3.4


Canton S

N

17875315

Resveratrol

10 µM

3.4


Dahomey

N

17875315

Lactic acid

0.01M

3.6


Oregon R

ND

110607

Lactic acid

0.001 M

3.6


Oregon R

ND

110607

Cynomorium
songaricum Rupr.

30 mg/ml

3.7


Canton S

N

22844336

Epicatechin

0.1 mg/ml

3.7


Oregon R

N

8326745

N-Acetyl
Cysteine

1 mM

3.7

1.6

Canton-S

Y

30243020

Gluconic
acid

0.25M
2x/week

3.8


Oregon R

ND

110607

Gluconic
acid

0.01M
2x/week

3.8


Oregon R

ND

110607

Curcumin

25 µM

4


Canton S

ND

25173182

Metformin

1 mM

4


Dahomey

N

23077661

Sodium
butyrate

100 mM

4.2


Ra

Y

23044027

Casein

1.25%

4.34

0

Canton-S

Y

27388939

Resveratrol

3.2 µM

4.5


Canton S

N

17875315

Resveratrol

1000 µM

4.5


Canton S

N

17875315

Rosa
damascena extract


4.5

7.4

w1118

N

21928072

Torin 1

1 µM

4.55

3.8

Dahomey

Y

29329306

Glucomannan
Hydrolysate

0.25% w/v

4.6


DGRP-40

Y

30137218

Melatonin

0.08% per
unit mass culture medium

4.8


Canton S

Y

10100152

Wortmannin

5 µM

5


Canton S

Y

24096697

Prunetin

25 µM

5.19

7.17

w1118

Y

26538555

Gluconic
acid

0.01 M

5.3


Oregon R

ND

110607

Proanthocyanidins
from Kunlun Chrysanthemum flowers


5.3

4.7

Oregon R+

N

25628774

CU701

0.30%

5.4


Canton S

Y

24305778

Melatonin

0.08% per
unit mass culture medium

5.5


Canton S

Y

10100152

N-Acetyl
Cysteine

10 nM

5.6

4.7

Canton-S

Y

30243020

N-Acetyl
Cysteine

100 µM

5.6

10.9

Canton-S

Y

30243020

Korean red
ginseng tonic

0.12 µg/ml

5.7


w1118

N

24265871

Proanthocyanidins
from Kunlun Chrysanthemum flowers


5.7

3.1

Oregon R+

N

25628774

Emblica
officinalis

20 ml

5.9


Y

24967413

Emblica
officinalis

30 ml

5.9


Y

24967413

Green tea
extract

1 mg/ml

5.9

5.3

Oregon-R-C

Y

17440995

CU701

0.30%

6


Canton S

N

24305778

Curcumin

5 µM

6


Canton S

ND

25173182

Minocycline

0.36mM

6


w1118

Y

29152127

Tartaric
acid

0.01M

6


Oregon R

ND

110607

Curcumin

0.5 mg/g

6.2

-5.2

Oregon R

N

22653297

Fucoxanthin

1 µM

6.2

0

Canton S

Y

29504896

Cranberry
anthocyanin extract

5 mg/ml

6.3

0

Oregon-R-C

Y

26159161

Curcumin

0.2 mg/g

6.74

8.77

Canton-S

Y

30488487

Rhodiola
rosea

2.5 mg/ml

6.8

-2.9

IF

N

24472572

Resveratrol

1 µM

6.9


Dahomey

N

17875315

Resveratrol

1000 µM

6.9


Dahomey

N

17875315

Epicatechin

0.5 µM

6.95

3.08

Canton S

Y

28066251

Metformin

5 mM

7


Dahomey

N

23077661

Tea
(Camellia sinensis) extract

1:10
dilution

7


Oregon R

Y

8326745

Epitalon

1*10^-9 %

7.1


Canton S

N

11087911

Gluconic
acid

0.01 M

7.2


Oregon R

ND

110607

Glucomannan
Hydrolysate

0.25% w/v

7.3


DGRP-136

Y

30137218

Epicatechin

1 mg/ml

7.4


Oregon R

N

8326745

N-Acetyl
Cysteine

1 µM

7.4

4.7

Canton-S

Y

30243020

Epicatechin

1 µM

7.5


Canton S

Y

28066251

Minocycline

0.36mM

7.7


Canton S

Y

29152127

Reference: HAGR
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