Life extension by compounds in Drosophila Melanogaster – Part 2

Part 1 Part 2 Part 3 Part 4

Name of Formulation Dose Avg/Med Lifespan Change (%) -96267.9 Max Lifespan Change (%) -94.993 Strain Significance (Yes: Y, No: N) Reference
Resveratrol 3.2 µM -2.8 Dahomey N 17875315
Resveratrol 32 µM -2.8 Dahomey N 17875315
Resveratrol 200 µM -2.8 Dahomey N 17875315
Resveratrol 1000 µM -2.8 Dahomey N 17875315
Quercetin 0.3µM -2.8 -13.07 Canton S Y 28066251
Resveratrol 200 µM -2.1 Canton S N 22083438
Resveratrol 32 µM -2 Canton S N 17875315
Resveratrol 1000 µM -2 Canton S N 17875315
Lactic acid 0.5M -1.9 Oregon R ND 110607
Gluconic acid 0.001 M -1.8 Oregon R ND 110607
Resveratrol 200 µM -1.5 Canton S N 22083438
Resveratrol 100 µM -1.4 Dahomey Y 17875315
Resveratrol 200 µM -1.4 Dahomey Y 17875315
Curcumin 50 µM -1 Canton S ND 25173182
AU701 0.30% -0.7 Canton S N 24305778
CU701 0.30% 0 Canton S N 24305778
Gluconic acid 0.01 M 0 Oregon R ND 110607
Gluconic acid 0.001 M 0 Oregon R ND 110607
Gluconic acid 0.5M 2x/week 0 Oregon R ND 110607
Metformin 1 mM 0 Dahomey N 23077661
Metformin 5 mM 0 Dahomey N 23077661
Metformin 5 mM 0 Dahomey N 23077661
Metformin 2.5 mM 0 Dahomey N 23077661
Resveratrol 200 µM 0 Canton S N 17875315
Resveratrol 1 µM 0 Canton S N 17875315
Resveratrol 3.2 µM 0 Canton S N 17875315
Resveratrol 200 µM 0 Canton S N 17875315
Resveratrol 100 µM 0 Canton S N 17875315
Resveratrol 10 µM 0 Canton S N 17875315
Resveratrol 100 µM 0 Canton S N 17875315
Resveratrol 1 µM 0 Canton S N 17875315
Resveratrol 200 µM 0 Dahomey N 17875315
Resveratrol 10 µM 0 Dahomey N 17875315
Resveratrol 100 µM 0 Dahomey N 17875315
Resveratrol 32 µM 0 Dahomey N 17875315
Resveratrol 10 µM 0 Dahomey N 17875315
Sodium borate 1 µM 0 Oregon R N 7889879
Tannic acid 1 mg/ml 0 Oregon R N 8326745
Tannic acid 0.1 mg/ml 0 Oregon R N 8326745
Tartaric acid 0.001 M 0 Oregon R ND 110607
Epicatechin 0.5 µM 0 2.24 Canton S N 28066251
Aronia extract 1 mg/mL 0 7.77 Canton-S N 30263675
Resveratrol 100 µM 1 Canton S N 22083438
Proanthocyanidins from Kunlun Chrysanthemum flowers 1 5.1 Oregon R+ N 25628774
AU701 0.30% 1.2 Canton S N 24305778
Resveratrol 1 µM 1.4 Dahomey N 17875315
Cynomorium songaricum Rupr. 10 mg/ml 1.5 Canton S N 22844336
Sodium borate 0.01 mM 1.5 Oregon R Y 7889879
Caffeine 0.1 mg/ml 1.7 Oregon R N 8326745
Calcium lactate 0.001 M 1.8 Oregon R ND 110607
Epicatechin 0.01 mg/ml 1.8 Oregon R N 8326745
Resveratrol 100 µM 1.8 Canton S N 22083438
Curcumin 5 µM 2 Canton S ND 25173182
Resveratrol 200 µM 2 Canton S N 17875315
Vitamin E 100 µg/ml 2 Canton S Y 17169403
Cynomorium songaricum Rupr. 20 mg/ml 2.2 Canton S N 22844336
Rhodiola rosea 2.5 mg/ml 2.4 -6 IF N 24472572
Platanus orientalis Extract 10 µg/ml 2.43 7.46 Oregon R Y 28887920
Morphine 2.6 Oregon R Y 21061062
Resveratrol 1 µM 2.8 Canton S N 17875315
Resveratrol 100 µM 2.8 Canton S N 17875315
Resveratrol 100 µM 2.8 Dahomey N 17875315
Resveratrol 3.2 µM 2.8 Dahomey N 17875315
Turmeric powder 2.5 g/L 2.9 Y 24967413
Curcumin 50 µM 3 Canton S ND 25173182
Resveratrol 1000 µM 3 Dahomey N 17875315
Sodium borate 0.1 mM 3 Oregon R Y 7889879
N-(3-(aminomethyl)benzyl)acetamidine 0.03 µM 3 13 Canton S Y 24096697
Curcumin 0.2 mg/g 3.01 4.91 Canton-S N 30488487
Epitalon 5*10^-6 % 3.2 Canton S N 11087911
Epitalon 1*10^-6 % 3.2 Canton S N 11087911
Morphine 3.2 Oregon R Y 21061062
Proanthocyanidins from Kunlun Chrysanthemum flowers 3.2 2.9 Oregon R+ N 25628774
Platanus orientalis Extract 1 µg/ml 3.26 1.49 Oregon R Y 28887920
Resveratrol 1000 µM 3.4 Canton S N 17875315
Resveratrol 10 µM 3.4 Dahomey N 17875315
Lactic acid 0.01M 3.6 Oregon R ND 110607
Lactic acid 0.001 M 3.6 Oregon R ND 110607
Cynomorium songaricum Rupr. 30 mg/ml 3.7 Canton S N 22844336
Epicatechin 0.1 mg/ml 3.7 Oregon R N 8326745
N-Acetyl Cysteine 1 mM 3.7 1.6 Canton-S Y 30243020
Gluconic acid 0.25M 2x/week 3.8 Oregon R ND 110607
Gluconic acid 0.01M 2x/week 3.8 Oregon R ND 110607
Curcumin 25 µM 4 Canton S ND 25173182
Metformin 1 mM 4 Dahomey N 23077661
Sodium butyrate 100 mM 4.2 Ra Y 23044027
Casein 1.25% 4.34 0 Canton-S Y 27388939
Resveratrol 3.2 µM 4.5 Canton S N 17875315
Resveratrol 1000 µM 4.5 Canton S N 17875315
Rosa damascena extract 4.5 7.4 w1118 N 21928072
Torin 1 1 µM 4.55 3.8 Dahomey Y 29329306
Glucomannan Hydrolysate 0.25% w/v 4.6 DGRP-40 Y 30137218
Melatonin 0.08% per unit mass culture medium 4.8 Canton S Y 10100152
Wortmannin 5 µM 5 Canton S Y 24096697
Prunetin 25 µM 5.19 7.17 w1118 Y 26538555
Gluconic acid 0.01 M 5.3 Oregon R ND 110607
Proanthocyanidins from Kunlun Chrysanthemum flowers 5.3 4.7 Oregon R+ N 25628774
CU701 0.30% 5.4 Canton S Y 24305778
Melatonin 0.08% per unit mass culture medium 5.5 Canton S Y 10100152
N-Acetyl Cysteine 10 nM 5.6 4.7 Canton-S Y 30243020
N-Acetyl Cysteine 100 µM 5.6 10.9 Canton-S Y 30243020
Korean red ginseng tonic 0.12 µg/ml 5.7 w1118 N 24265871
Proanthocyanidins from Kunlun Chrysanthemum flowers 5.7 3.1 Oregon R+ N 25628774
Emblica officinalis 20 ml 5.9 Y 24967413
Emblica officinalis 30 ml 5.9 Y 24967413
Green tea extract 1 mg/ml 5.9 5.3 Oregon-R-C Y 17440995
CU701 0.30% 6 Canton S N 24305778
Curcumin 5 µM 6 Canton S ND 25173182
Minocycline 0.36mM 6 w1118 Y 29152127
Tartaric acid 0.01M 6 Oregon R ND 110607
Curcumin 0.5 mg/g 6.2 -5.2 Oregon R N 22653297
Fucoxanthin 1 µM 6.2 0 Canton S Y 29504896
Cranberry anthocyanin extract 5 mg/ml 6.3 0 Oregon-R-C Y 26159161
Curcumin 0.2 mg/g 6.74 8.77 Canton-S Y 30488487
Rhodiola rosea 2.5 mg/ml 6.8 -2.9 IF N 24472572
Resveratrol 1 µM 6.9 Dahomey N 17875315
Resveratrol 1000 µM 6.9 Dahomey N 17875315
Epicatechin 0.5 µM 6.95 3.08 Canton S Y 28066251
Metformin 5 mM 7 Dahomey N 23077661
Tea (Camellia sinensis) extract 1:10 dilution 7 Oregon R Y 8326745
Epitalon 1*10^-9 % 7.1 Canton S N 11087911
Gluconic acid 0.01 M 7.2 Oregon R ND 110607
Glucomannan Hydrolysate 0.25% w/v 7.3 DGRP-136 Y 30137218
Epicatechin 1 mg/ml 7.4 Oregon R N 8326745
N-Acetyl Cysteine 1 µM 7.4 4.7 Canton-S Y 30243020
Epicatechin 1 µM 7.5 Canton S Y 28066251
Minocycline 0.36mM 7.7 Canton S Y 29152127
Reference: HAGR